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Pesquisa : D27.505.696.399.472.277.540 [Categoria DeCS]
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[PMID]:28992480
[Au] Autor:Fan W; Lv Y; Ren S; Shao M; Shen T; Huang K; Zhou J; Yan L; Song S
[Ad] Endereço:College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, Jiangsu Province, China.
[Ti] Título:Zearalenone (ZEA)-induced intestinal inflammation is mediated by the NLRP3 inflammasome.
[So] Source:Chemosphere;190:272-279, 2018 Jan.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:To ascertain whether zearalenone (ZEA) could induce intestinal inflammation and investigate its possible mechanism, we investigated inflammatory cytokine release and the activation of the NLRP3 inflammasome after ZEA treatment both in vitro or in vivo. First, intestinal porcine enterocyte cell line (IPEC-J2) cells and mouse peritoneal macrophages were treated with ZEA to detect NLRP3 inflammasome activation, and the role of reactive oxygen species (ROS) in ZEA-induced inflammation was investigated. Then, Balb/c mice were fed a gavage of ZEA, and the disease activity indices (DAIs) and histological analysis were used to assess intestinal inflammation. Our study showed that the mRNA expression of NLRP3 inflammasome, pro-interleukin-1ß (pro-IL-1ß), and pro-interleukin-18 (pro-IL-18) was up-regulated 0.5- to 1-fold and that the release of IL-1ß and IL-18 increased from 48 pg mL to 55 pg mL and 110 pg mL to 145 pg mL , respectively. However, ROS inhibitor N-acetyl-l-cysteine (NAC) reduced IL-1ß and IL-18 release to 45 pg mL and 108 pg mL . Moreover, the same phenomenon was observed in intestinal tissues of ZEA-treated mice. In addition, clinical parameters of treated mice showed stools became loose and contained mucous. In addition, the presence of gross blood stool was found in the last 2 d. Histological analysis showed obvious inflammatory cell infiltration and tissue damage in the colon. These findings uncovered a possible mechanism of intestinal mucosal innate immunity in response to mycotoxin ZEA that ZEA could activate the ROS-mediated NLRP3 inflammasome and, in turn, contribute to the caspase-1-dependent activation of the inflammatory cytokines IL-1ß and IL-18.
[Mh] Termos MeSH primário: Inflamassomos/fisiologia
Inflamação/induzido quimicamente
Proteína 3 que Contém Domínio de Pirina da Família NLR/fisiologia
Espécies Reativas de Oxigênio
Zearalenona/toxicidade
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Estrogênios não Esteroides
Interleucina-18/genética
Interleucina-18/metabolismo
Interleucina-1beta/genética
Interleucina-1beta/metabolismo
Intestinos/patologia
Macrófagos/metabolismo
Camundongos
Proteína 3 que Contém Domínio de Pirina da Família NLR/genética
RNA Mensageiro/metabolismo
Espécies Reativas de Oxigênio/metabolismo
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Estrogens, Non-Steroidal); 0 (Inflammasomes); 0 (Interleukin-18); 0 (Interleukin-1beta); 0 (NLR Family, Pyrin Domain-Containing 3 Protein); 0 (RNA, Messenger); 0 (Reactive Oxygen Species); 5W827M159J (Zearalenone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171010
[St] Status:MEDLINE


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[PMID]:29030156
[Au] Autor:Blokland MH; van Tricht EF; van Ginkel LA; Sterk SS
[Ad] Endereço:RIKILT Wageningen University & Research, P.O. Box 230, Wageningen, The Netherlands. Electronic address: marco.blokland@wur.nl.
[Ti] Título:Applicability of an innovative steroid-profiling method to determine synthetic growth promoter abuse in cattle.
[So] Source:J Steroid Biochem Mol Biol;174:265-275, 2017 Nov.
[Is] ISSN:1879-1220
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A robust LC-MS/MS method was developed to quantify a large number of phase I and phase II steroids in urine. The decision limit is for most compounds lower than 1ngml with a measurement uncertainty smaller than 30%. The method is fully validated and was applied to assess the influence of administered synthetic steroids and beta-agonists on the steroidogenesis. From three animal experiments, clenbuterol, diethylstilbestrol and stanozolol, the steroid profiles in urine of bovine animals were compared before and after treatment. It was demonstrated that the steroid profiles were altered due to these treatments. A predictive multivariate model was built to identify deviations from normal population steroid profiles. The abuse of synthetic steroids can be detected in urine samples from bovine animals using this model. The samples from the animal experiments were randomly analysed using this method and predictive model. It was shown that these samples were predicted correctly in the exogenous steroids group.
[Mh] Termos MeSH primário: Anabolizantes/farmacologia
Clembuterol/farmacologia
Dietilestilbestrol/farmacologia
Estrogênios não Esteroides/farmacologia
Estanozolol/farmacologia
Esteroides/urina
[Mh] Termos MeSH secundário: Animais
Bovinos/urina
Cromatografia Líquida de Alta Pressão
Masculino
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anabolic Agents); 0 (Estrogens, Non-Steroidal); 0 (Steroids); 4R1VB9P8V3 (Stanozolol); 731DCA35BT (Diethylstilbestrol); XTZ6AXU7KN (Clenbuterol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171015
[St] Status:MEDLINE


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[PMID]:28938483
[Au] Autor:Hindman AR; Mo XM; Helber HL; Kovalchin CE; Ravichandran N; Murphy AR; Fagan AM; St John PM; Burd CJ
[Ad] Endereço:Department of Molecular Genetics, The Ohio State University, Columbus, Ohio 43210.
[Ti] Título:Varying Susceptibility of the Female Mammary Gland to In Utero Windows of BPA Exposure.
[So] Source:Endocrinology;158(10):3435-3447, 2017 Oct 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In utero exposure to the endocrine disrupting compound bisphenol A (BPA) is known to disrupt mammary gland development and increase tumor susceptibility in rodents. It is unclear whether different periods of in utero development might be more susceptible to BPA exposure. We exposed pregnant CD-1 mice to BPA at different times during gestation that correspond to specific milestones of in utero mammary gland development. The mammary glands of early-life and adult female mice, exposed in utero to BPA, were morphologically and molecularly (estrogen receptor-α and Ki67) evaluated for developmental abnormalities. We found that BPA treatment occurring before mammary bud invasion into the mesenchyme [embryonic day (E)12.5] incompletely resulted in the measured phenotypes of mammary gland defects. Exposing mice up to the point at which the epithelium extends into the precursor fat pad (E16.5) resulted in a nearly complete BPA phenotype and exposure during epithelial extension (E15.5 to E18.5) resulted in a partial phenotype. Furthermore, the relative differences in phenotypes between exposure windows highlight the substantial correlations between early-life molecular changes (estrogen receptor-α and Ki67) in the stroma and the epithelial elongation defects in mammary development. These data further implicate BPA action in the stroma as a critical mediator of epithelial phenotypes.
[Mh] Termos MeSH primário: Compostos Benzidrílicos/farmacologia
Receptor alfa de Estrogênio/efeitos dos fármacos
Estrogênios não Esteroides/farmacologia
Antígeno Ki-67/efeitos dos fármacos
Glândulas Mamárias Animais/efeitos dos fármacos
Fenóis/farmacologia
Efeitos Tardios da Exposição Pré-Natal
[Mh] Termos MeSH secundário: Líquido Amniótico/química
Animais
Cromatografia Líquida de Alta Pressão
Receptor alfa de Estrogênio/metabolismo
Feminino
Imuno-Histoquímica
Antígeno Ki-67/metabolismo
Glândulas Mamárias Animais/embriologia
Glândulas Mamárias Animais/metabolismo
Glândulas Mamárias Animais/patologia
Camundongos
Fenótipo
Gravidez
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzhydryl Compounds); 0 (Estrogen Receptor alpha); 0 (Estrogens, Non-Steroidal); 0 (Ki-67 Antigen); 0 (Phenols); MLT3645I99 (bisphenol A)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171115
[Lr] Data última revisão:
171115
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170923
[St] Status:MEDLINE
[do] DOI:10.1210/en.2017-00116


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[PMID]:28837831
[Au] Autor:Pang J; Zhou Q; Sun X; Li L; Zhou B; Zeng F; Zhao Y; Shen W; Sun Z
[Ad] Endereço:Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
[Ti] Título:Effect of low-dose zearalenone exposure on reproductive capacity of male mice.
[So] Source:Toxicol Appl Pharmacol;333:60-67, 2017 Oct 15.
[Is] ISSN:1096-0333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Zearalenone (ZEA), a kind of nonsteroidal mycotoxin with estrogenic effects, can influence animal reproductive capacity through interfering with estrogen signaling pathway. Previous studies have shown exposure to ZEA at high doses (higher than No-Observed Effect Level, NOEL) had a significant impact on mouse sperm quality and pregnant rate, but little is known about the effect of exposure to ZEA at low doses (lower than NOEL) on mouse reproductive capacity. This study evaluated the effects of exposure to low-dose ZEA on mouse spermatogenesis and semen quality. Male mice (CD-1) of 21days were exposed to ZEA at 20, or 40µg/kg body weight for 14, 28 or 42days. After exposure to ZEA for 14days, the spermatogenic cells in seminiferous tubules were declined dose-independently; however in groups treated by ZEA for 28days, the spermatogenic cells were declined dose-dependently. Moreover, after treatment for 28days or 42days, the DNA double stand break (DSB) in spermatogenic cells were increased in a dose-dependent manner in treated groups. Compared with the control group, the sperm concentration, viability, motility, and hyperactive rate in treated groups were decreased dose-dependently and time-dependently. Meanwhile, deformity and mortality rate of sperm in treated groups were increased remarkably dose-dependently too. In conclusion, low dose ZEA impaired male reproductive capacity especially in spermatogenesis and semen quality of mouse.
[Mh] Termos MeSH primário: Estrogênios não Esteroides/toxicidade
Reprodução/efeitos dos fármacos
Espermatozoides/efeitos dos fármacos
Zearalenona/toxicidade
[Mh] Termos MeSH secundário: Animais
Quebras de DNA de Cadeia Dupla
Relação Dose-Resposta a Droga
Masculino
Camundongos
Contagem de Espermatozoides
Motilidade Espermática/efeitos dos fármacos
Espermatogênese/efeitos dos fármacos
Espermatozoides/anormalidades
Espermatozoides/metabolismo
Espermatozoides/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Estrogens, Non-Steroidal); 5W827M159J (Zearalenone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170825
[St] Status:MEDLINE


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[PMID]:28704378
[Au] Autor:Szafran AT; Stossi F; Mancini MG; Walker CL; Mancini MA
[Ad] Endereço:Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America.
[Ti] Título:Characterizing properties of non-estrogenic substituted bisphenol analogs using high throughput microscopy and image analysis.
[So] Source:PLoS One;12(7):e0180141, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Animal studies have linked the estrogenic properties of bisphenol A (BPA) to adverse effects on the endocrine system. Because of concerns for similar effects in humans, there is a desire to replace BPA in consumer products, and a search for BPA replacements that lack endocrine-disrupting bioactivity is ongoing. We used multiple cell-based models, including an established multi-parametric, high throughput microscopy-based platform that incorporates engineered HeLa cell lines with visible ERα- or ERß-regulated transcription loci, to discriminate the estrogen-like and androgen-like properties of previously uncharacterized substituted bisphenol derivatives and hydroquinone. As expected, BPA induced 70-80% of the estrogen-like activity via ERα and ERß compared to E2 in the HeLa prolactin array cell line. 2,2' BPA, Bisguaiacol F, CHDM 4-hydroxybuyl acrylate, hydroquinone, and TM modified variants of BPF showed very limited estrogen-like or androgen-like activity (< 10% of that observed with the control compounds). Interestingly, TM-BFP and CHDM 4-hydroxybuyl acrylate, but not their derivatives, demonstrated evidence of anti-estrogenic and anti-androgenic activity. Our findings indicate that Bisguaiacol F, TM-BFP-ER and TM-BPF-DGE demonstrate low potential for affecting estrogenic or androgenic endocrine activity. This suggest that the tested compounds could be suitable commercially viable alternatives to BPA.
[Mh] Termos MeSH primário: Estrogênios não Esteroides/farmacologia
Ensaios de Triagem em Larga Escala/métodos
Transcrição Genética/efeitos dos fármacos
[Mh] Termos MeSH secundário: Compostos Benzidrílicos/farmacologia
Receptor alfa de Estrogênio/metabolismo
Receptor beta de Estrogênio/metabolismo
Estrogênios não Esteroides/química
Células HeLa
Seres Humanos
Hidroquinonas/farmacologia
Células MCF-7
Microscopia
Estrutura Molecular
Fenóis/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzhydryl Compounds); 0 (ESR2 protein, human); 0 (Estrogen Receptor alpha); 0 (Estrogen Receptor beta); 0 (Estrogens, Non-Steroidal); 0 (Hydroquinones); 0 (Phenols); 0 (estrogen receptor alpha, human); MLT3645I99 (bisphenol A); XV74C1N1AE (hydroquinone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180141


  6 / 3137 MEDLINE  
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[PMID]:28582417
[Au] Autor:Zheng H; Zhou X; Li DK; Yang F; Pan H; Li T; Miao M; Li R; Yuan W
[Ad] Endereço:Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai, China.
[Ti] Título:Genome-wide alteration in DNA hydroxymethylation in the sperm from bisphenol A-exposed men.
[So] Source:PLoS One;12(6):e0178535, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Environmental BPA exposure has been shown to impact human sperm concentration and motility, as well as rodent spermatogenesis. However, it is unclear whether BPA exposure is associated with alteration in DNA hydroxymethylation, a marker for epigenetic modification, in human sperm. A genome-wide DNA hydroxymethylation study was performed using sperm samples of men who were occupationally exposed to BPA. Compared with controls who had no occupational BPA exposure, the total levels of 5-hydroxymethylcytosine (5hmc) increased significantly (19.37% increase) in BPA-exposed men, with 72.69% of genome regions harboring 5hmc. A total of 9,610 differential 5hmc regions (DhMRs) were revealed in BPA-exposed men relative to controls, which were mainly located in intergenic and intron regions. These DhMRs were composed of 8,670 hyper-hMRs and 940 hypo-hMRs, affecting 2,008 genes and the repetitive elements. The hyper-hMRs affected genes were enriched in pathways associated with nervous system, development, cardiovascular diseases and signal transduction. Additionally, enrichment of 5hmc was observed in the promoters of eight maternally expressed imprinted genes in BPA-exposed sperm. Some of the BPA-affected genes, for example, MLH1, CHD2, SPATA12 and SPATA20 might participate in the response to DNA damage in germ cells caused by BPA. Our analysis showed that enrichment of 5hmc both in promoters and gene bodies is higher in the genes whose expression has been detected in human sperm than those whose expression is absent. Importantly, we observed that BPA exposure affected the 5hmc level in 11.4% of these genes expressed in sperm, and in 6.85% of the sperm genome. Finally, we also observed that BPA exposure tends to change the 5hmc enrichment in the genes which was previously reported to be distributed with the trimethylated Histone 3 (H3K27me3, H3K4me2 or H3K4me3) in sperm. Thus, these results suggest that BPA exposure likely interferes with gene expression via affecting DNA hydroxymethylation in a way partially dependent on trimethylation of H3 in human spermatogenesis. Our current study reveals a new mechanism by which BPA exposure reduces human sperm quality.
[Mh] Termos MeSH primário: 5-Metilcitosina/análogos & derivados
Poluentes Ocupacionais do Ar/farmacologia
Compostos Benzidrílicos/farmacologia
Epigênese Genética
Estrogênios não Esteroides/farmacologia
Fenóis/farmacologia
Espermatogênese/efeitos dos fármacos
[Mh] Termos MeSH secundário: 5-Metilcitosina/metabolismo
Adulto
Metilação de DNA
Proteínas de Ligação a DNA/genética
Proteínas de Ligação a DNA/metabolismo
Exposição Ambiental/efeitos adversos
Genoma Humano
Histonas/genética
Histonas/metabolismo
Proteínas de Homeodomínio/genética
Proteínas de Homeodomínio/metabolismo
Seres Humanos
Hidroxilação
Masculino
Meia-Idade
Proteína 1 Homóloga a MutL/genética
Proteína 1 Homóloga a MutL/metabolismo
Regiões Promotoras Genéticas
Isoformas de Proteínas/genética
Isoformas de Proteínas/metabolismo
Contagem de Espermatozoides
Espermatozoides/efeitos dos fármacos
Espermatozoides/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants, Occupational); 0 (Benzhydryl Compounds); 0 (CHD2 protein, human); 0 (DNA-Binding Proteins); 0 (Estrogens, Non-Steroidal); 0 (Histones); 0 (Homeodomain Proteins); 0 (MLH1 protein, human); 0 (Phenols); 0 (Protein Isoforms); 0 (SPATA12 protein, human); 1123-95-1 (5-hydroxymethylcytosine); 6R795CQT4H (5-Methylcytosine); EC 3.6.1.3 (MutL Protein Homolog 1); MLT3645I99 (bisphenol A)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178535


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[PMID]:28552778
[Au] Autor:Liu KH; Sun XF; Feng YZ; Cheng SF; Li B; Li YP; Shen W; Li L
[Ad] Endereço:College of Animal Science and Technology, Institute of Reproductive Sciences, Qingdao Agricultural University, Qingdao 266109, China.
[Ti] Título:The impact of Zearalenone on the meiotic progression and primordial follicle assembly during early oogenesis.
[So] Source:Toxicol Appl Pharmacol;329:9-17, 2017 Aug 15.
[Is] ISSN:1096-0333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Zearalenone (ZEA) is a mycotoxin produced by fusarium graminearum. It can cause abnormal reproductive function by acting as an environmental estrogen. Research has traditionally focused on acute and chronic injury on mammalian reproductive capacity after ZEA treatment. Little research has been done studying the effects of ZEA exposure on early oogenesis. In this study, we investigate the effects of ZEA exposure on meiotic entry, DNA double-strand breaks (DSBs), and primordial follicle assembly during murine early oogenesis. The results show that ZEA exposure significantly decreased the percentage of diplotene stage germ cells, and made more germ cells remain at zygotene or pachytene stages. Moreover, the mRNA expression level of meiosis-related genes was significantly reduced after ZEA treatment. ZEA exposure significantly increased DNA-DSBs at the diplotene stage. Meanwhile, DNA damage repair genes such as RAD51 and BRCA1 were activated. Furthermore, maternal exposure to ZEA significantly decreased the number of primordial follicles in newborn mouse ovaries. In conclusion, ZEA exposure impairs mouse female germ cell meiotic progression, DNA-DSBs, and primordial follicle assembly.
[Mh] Termos MeSH primário: Disruptores Endócrinos/toxicidade
Estrogênios não Esteroides/toxicidade
Meiose/efeitos dos fármacos
Oogênese/efeitos dos fármacos
Folículo Ovariano/efeitos dos fármacos
Óvulo/efeitos dos fármacos
Zearalenona/toxicidade
[Mh] Termos MeSH secundário: Animais
Quebras de DNA de Cadeia Dupla
Reparo do DNA/efeitos dos fármacos
Feminino
Prófase Meiótica I/efeitos dos fármacos
Camundongos
Folículo Ovariano/metabolismo
Folículo Ovariano/patologia
Óvulo/metabolismo
Óvulo/patologia
Gravidez
Rad51 Recombinase/metabolismo
Medição de Risco
Proteínas Supressoras de Tumor/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Brca1 protein, mouse); 0 (Endocrine Disruptors); 0 (Estrogens, Non-Steroidal); 0 (Tumor Suppressor Proteins); 5W827M159J (Zearalenone); EC 2.7.7.- (Rad51 Recombinase); EC 2.7.7.- (Rad51 protein, mouse)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170530
[St] Status:MEDLINE


  8 / 3137 MEDLINE  
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[PMID]:28549332
[Au] Autor:Ju L; Wu P; Lai X; Yang S; Gong B; Chen M; Zhu N
[Ad] Endereço:School of Environment and Energy, South China University of Technology, Guangzhou Higher Education Mega Centre, Guangzhou 510006, PR China; The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters, Ministry of Education, Guangzhou 510006, PR China; Guangdong Provincial Enginee
[Ti] Título:Synthesis and characterization of Fullerene modified ZnAlTi-LDO in photo-degradation of Bisphenol A under simulated visible light irradiation.
[So] Source:Environ Pollut;228:234-244, 2017 Sep.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, ZnAlTi layered double hydroxide (ZnAlTi-LDH) combined with fullerene (C ) was fabricated by the urea method, and calcined under vacuum atmosphere to obtain nanocomposites of C -modified ZnAlTi layered double oxide (ZnAlTi-LDO). The morphology, structure and composition of the nanocomposites were analyzed by Scanning Electron Microscopy, High-resolution transmission electron microscopy, X-ray diffraction patterns, Fourier transform infrared and specific surface area. The UV-vis diffuse reflectance spectra indicated that the incorporation of C expanded the absorption of ZnAlTi-LDO to visible-light region. The photo-degradation experiment was conducted by using a series of C modified ZnAlTi-LDO with different C weight percentage to degrade Bisphenol A (BPA) under simulated visible light irradiation. In this experiment, the degradation rate of C modified ZnAlTi-LDO in photo-degradation of BPA under simulated visible light irradiation was over 80%. The intermediates formed in the degradation of BPA process by using LDO/C -5% were 4-hydroxyphenyl-2-propanol, 4-isopropenylphenol and Phenol. Photogenerated holes, superoxide radical species, ·OH and singlet oxygen were considered to be responsible for the photodegradation process, among which superoxide radical species and ·OH played a predominant role in the photocatalytic reaction system. C modified ZnAlTi-LDO catalysts for photocatalytic reduction shows great potential in degradation of organic pollutants and environmental remediation.
[Mh] Termos MeSH primário: Compostos Benzidrílicos/química
Estrogênios não Esteroides/química
Fulerenos/química
Modelos Químicos
Fenóis/química
Processos Fotoquímicos
[Mh] Termos MeSH secundário: Compostos Benzidrílicos/análise
Catálise
Estrogênios não Esteroides/análise
Luz
Nanocompostos/química
Óxidos
Fenóis/análise
Fotólise
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzhydryl Compounds); 0 (Estrogens, Non-Steroidal); 0 (Fullerenes); 0 (Oxides); 0 (Phenols); MLT3645I99 (bisphenol A); NP9U26B839 (fullerene C60)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170811
[Lr] Data última revisão:
170811
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170527
[St] Status:MEDLINE


  9 / 3137 MEDLINE  
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[PMID]:28549143
[Au] Autor:Susiarjo M; Xin F; Stefaniak M; Mesaros C; Simmons RA; Bartolomei MS
[Ad] Endereço:Epigenetics Institute, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
[Ti] Título:Bile Acids and Tryptophan Metabolism Are Novel Pathways Involved in Metabolic Abnormalities in BPA-Exposed Pregnant Mice and Male Offspring.
[So] Source:Endocrinology;158(8):2533-2542, 2017 Aug 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Increasing evidence has demonstrated that exposure to endocrine-disrupting chemicals impacts maternal and fetal health, but the underlying mechanisms are still unclear. We previously showed that dietary exposure to 10 µg/kg body weight (bw)/d and 10 mg/kg bw/d of bisphenol A (BPA) during pregnancy induced metabolic abnormalities in F1 male offspring and gestational glucose intolerance in F0 pregnant mice. The aim of this study was to elucidate the underlying etiologies of BPA exposure-induced metabolic disease by analyzing the male fetal liver metabolome. Using the Metabolon Discover HD4 Platform, our laboratory identified metabolic pathways that were altered by BPA exposure, including biochemicals in lipid and amino acid metabolism. Specifically, primary and secondary bile acids were increased in liver from BPA-exposed embryonic day 18.5 male fetuses. We subsequently showed that increased bile acid was associated with a defective farnesoid X receptor-dependent negative feedback mechanism in BPA-exposed fetuses. In addition, through metabolomics, we observed that BPA-exposed fetuses had elevated tryptophan levels. Independent liquid chromatography and mass spectrometry measurement revealed that BPA-exposed dams also had increased tryptophan levels relative to those of controls. Because several key enzymes in tryptophan catabolism are vitamin B6 dependent and vitamin B6 deficiencies have been linked to gestational diabetes, we tested the impact of vitamin B6 supplementation and showed that it rescued gestational glucose intolerance in BPA-exposed pregnant mice. Our study has therefore identified two pathways (bile acid and tryptophan metabolism) that potentially underlie BPA-induced maternal and fetal metabolic disease.
[Mh] Termos MeSH primário: Compostos Benzidrílicos/toxicidade
Ácidos e Sais Biliares/metabolismo
Estrogênios não Esteroides/toxicidade
Fenóis/toxicidade
Triptofano/metabolismo
[Mh] Termos MeSH secundário: Animais
Compostos Benzidrílicos/administração & dosagem
Relação Dose-Resposta a Droga
Estrogênios não Esteroides/administração & dosagem
Feminino
Fígado/efeitos dos fármacos
Fígado/metabolismo
Masculino
Camundongos
Fenóis/administração & dosagem
Gravidez
Efeitos Tardios da Exposição Pré-Natal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzhydryl Compounds); 0 (Bile Acids and Salts); 0 (Estrogens, Non-Steroidal); 0 (Phenols); 8DUH1N11BX (Tryptophan); MLT3645I99 (bisphenol A)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170527
[St] Status:MEDLINE
[do] DOI:10.1210/en.2017-00046


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[PMID]:28500084
[Au] Autor:Lv Q; Gao R; Peng C; Yi J; Liu L; Yang S; Li D; Hu J; Luo T; Mei M; Song Y; Wu C; Xiao X; Li Q
[Ad] Endereço:Department of EndocrinologyThe First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
[Ti] Título:Bisphenol A promotes hepatic lipid deposition involving Kupffer cells M1 polarization in male mice.
[So] Source:J Endocrinol;234(2):143-154, 2017 Aug.
[Is] ISSN:1479-6805
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Bisphenol A (BPA), one of the most common environmental endocrine disruptors, is considered to promote hepatic lipid deposition. However, the mechanism has not been fully elucidated. The polarization of Kupffer cells (KCs) plays an important role in hepatic inflammation by promoting pro-inflammatory M1 phenotype (M1KCs), which contributes to dysregulated lipid metabolism. The purpose of this study is to investigate the role of KC polarization in BPA-induced hepatosteatosis in male mice. In this study, we examined hepatic lipid contents and quantified M1KC in BPA-treated CD1 mice, and further explored the interaction between KCs and hepatocytes using conditional HepG2 cell culture. BPA treatment significantly increased hepatic fat contents in CD1 mice, accompanied by increased number of pro-inflammatory M1KCs and enhanced secretion of inflammatory cytokines. Increased lipid contents were also observed in HepG2 cells treated with BPA. Interestingly, higher TG contents were observed in HepaG2 cells treated with conditional media from BPA-treated KCs, compared with those treated with BPA directly. Incubation of KCs with BPA promoted the polarization of KCs to pro-inflammatory M1 dominant subtypes, which was blocked by estrogen antagonist ICI182780. Taken together, our results revealed that M1KCs polarization is involved in BPA-induced hepatic fat deposition, which is possibly associated with the estrogen receptor signaling pathway.
[Mh] Termos MeSH primário: Compostos Benzidrílicos/toxicidade
Estrogênios não Esteroides/toxicidade
Macrófagos do Fígado/metabolismo
Metabolismo dos Lipídeos/efeitos dos fármacos
Fígado/metabolismo
Fenóis/toxicidade
[Mh] Termos MeSH secundário: Animais
Transporte Biológico/fisiologia
Células Cultivadas
Feminino
Regulação da Expressão Gênica/fisiologia
Macrófagos do Fígado/classificação
Masculino
Camundongos
Receptores Estrogênicos/metabolismo
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzhydryl Compounds); 0 (Estrogens, Non-Steroidal); 0 (Phenols); 0 (Receptors, Estrogen); MLT3645I99 (bisphenol A)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170514
[St] Status:MEDLINE
[do] DOI:10.1530/JOE-17-0028



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