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  1 / 3212 MEDLINE  
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[PMID]:29419673
[Au] Autor:Choi J; Lee HW; Lee JA; Lim HJ; Lee MS
[Ad] Endereço:Clinical Research Division, Korea Institute of Oriental Medicine.
[Ti] Título:Aromatherapy for managing menopausal symptoms: A protocol for systematic review and meta-analysis.
[So] Source:Medicine (Baltimore);97(6):e9792, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Aromatherapy is often used as a complementary therapy for women's health. This systematic review aims to evaluate the therapeutic effects of aromatherapy as a management for menopausal symptoms. METHODS: Eleven electronic databases will be searched from inception to February 2018. Randomized controlled trials that evaluated any type of aromatherapy against any type of control in individuals with menopausal symptoms will be eligible. The methodological quality will be assessed using the Cochrane risk of bias tool. Two authors will independently assess each study for eligibility and risk of bias and to extract data. RESULTS: This study will provide a high quality synthesis of current evidence of aromatherapy for menopausal symptoms measured with Menopause Rating Scale, the Kupperman Index, the Greene Climacteric Scale, or other validated questionnaires. CONCLUSIONS: The conclusion of our systematic review will provide evidence to judge whether aromatherapy is an effective intervention for patient with menopausal women. ETHICS AND DISSEMINATION: Ethical approval will not be required, given that this protocol is for a systematic review. The systematic review will be published in a peer-reviewed journal. The review will also be disseminated electronically and in print. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42017079191.
[Mh] Termos MeSH primário: Aromaterapia/métodos
Fogachos/terapia
Menopausa
Metanálise como Assunto
Fitoestrógenos/uso terapêutico
[Mh] Termos MeSH secundário: Feminino
Fogachos/etiologia
Seres Humanos
Menopausa/efeitos dos fármacos
Menopausa/fisiologia
Projetos de Pesquisa
Saúde da Mulher
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phytoestrogens)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180209
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009792


  2 / 3212 MEDLINE  
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[PMID]:29189005
[Au] Autor:Tsugami Y; Matsunaga K; Suzuki T; Nishimura T; Kobayashi K
[Ad] Endereço:Laboratory of Cell and Tissue Biology, Research Faculty of Agriculture, Hokkaido University , North 9, West 9, 060-8589 Sapporo, Japan.
[Ti] Título:Phytoestrogens Weaken the Blood-Milk Barrier in Lactating Mammary Epithelial Cells by Affecting Tight Junctions and Cell Viability.
[So] Source:J Agric Food Chem;65(50):11118-11124, 2017 Dec 20.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:During lactation, mammary epithelial cells (MECs) form the blood-milk barrier by less-permeable tight junctions (TJs) to prevent the leakage of milk components. Phytoestrogens affect the proliferation, differentiation, and apoptosis of MECs. However, it remains unclear whether phytoestrogens are involved in the blood-milk barrier. Therefore, we investigated the influence of phytoestrogens (coumestrol, genistein, and daidzein) by using an in vitro mouse-MEC-culture model. The results showed that coumestrol and genistein changed the expression of TJ proteins (claudins-3 and -4 and occludin), weakened barrier function, and reduced ß-casein production. Daidzein also weakened barrier function without inhibiting ß-casein production. Additionally, coumestrol and genistein induced apoptosis in MECs. These results indicate that phytoestrogens weaken the blood-milk barrier by directly affecting TJs and the cellular viability of lactating MECs in different ways.
[Mh] Termos MeSH primário: Cumestrol/farmacologia
Células Epiteliais/metabolismo
Genisteína/farmacologia
Isoflavonas/farmacologia
Glândulas Mamárias Animais/citologia
Leite/metabolismo
Fitoestrógenos/farmacologia
Junções Íntimas/metabolismo
[Mh] Termos MeSH secundário: Animais
Caseínas/metabolismo
Sobrevivência Celular/efeitos dos fármacos
Células Epiteliais/citologia
Feminino
Seres Humanos
Lactação
Glândulas Mamárias Animais/irrigação sanguínea
Glândulas Mamárias Animais/efeitos dos fármacos
Glândulas Mamárias Animais/metabolismo
Camundongos
Camundongos Endogâmicos ICR
Junções Íntimas/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Caseins); 0 (Isoflavones); 0 (Phytoestrogens); 6287WC5J2L (daidzein); DH2M523P0H (Genistein); V7NW98OB34 (Coumestrol)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180110
[Lr] Data última revisão:
180110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04786


  3 / 3212 MEDLINE  
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[PMID]:28945939
[Au] Autor:Thaung Zaw JJ; Howe PRC; Wong RHX
[Ad] Endereço:Clinical Nutrition Research Centre, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia.
[Ti] Título:Does phytoestrogen supplementation improve cognition in humans? A systematic review.
[So] Source:Ann N Y Acad Sci;1403(1):150-163, 2017 Sep.
[Is] ISSN:1749-6632
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recent evidence indicates that resveratrol, a phytoestrogen, can improve cognitive function in postmenopausal women by enhancing cerebral vasodilator responsiveness. We examine the effects of phytoestrogen supplementation on cognition and compare resveratrol with other phytoestrogens. Databases were searched for reports of randomized controlled trials (RCTs) containing terms describing phytoestrogens together with terms relating to cognition. Effect sizes were determined for changes in cognition. We identified 23 RCTs, 15 with isoflavone and eight with resveratrol or grape formulations. Six soy isoflavone studies showed positive cognitive effects of medium size. Greater benefits were seen in women who were <10 years postmenopausal and supplemented for <6 months. Small-to-medium effect-size cognitive benefits of resveratrol were seen in four studies of older adults of mixed gender and in postmenopausal women who took 150-200 mg resveratrol daily for at least 14 weeks. No benefits were seen in three studies using red clover or grape formulations. Supplementation with either soy isoflavone or resveratrol improved executive function and memory domains of cognitively normal older adults in half of the included studies, mostly with medium effect sizes. The cognitive benefit of resveratrol was related to improved cerebral perfusion.
[Mh] Termos MeSH primário: Cognição/efeitos dos fármacos
Suplementos Nutricionais
Fitoestrógenos/farmacologia
Estilbenos/farmacologia
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Phytoestrogens); 0 (Stilbenes); Q369O8926L (resveratrol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170926
[St] Status:MEDLINE
[do] DOI:10.1111/nyas.13459


  4 / 3212 MEDLINE  
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[PMID]:28845762
[Au] Autor:Qadir MI; Cheema BN
[Ad] Endereço:Institute of Molecular Biology & Biotechnology, Bahauddin Zakariya University, Multan, Pakistan.
[Ti] Título:Phytoestrogens and Related Food Components in the Prevention of Cancer.
[So] Source:Crit Rev Eukaryot Gene Expr;27(2):99-112, 2017.
[Is] ISSN:1045-4403
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Great progress has been made in the fight against disease in many different fields of medicine, especially in the field of natural medicine. Phytoestrogens and related compounds play a major role in the prevention and treatment of cancer. Chemoprevention, a narrative approach for controlling cancer, involves the use of specific natural products or synthetic chemical agents to overturn, repress, or prevent pre-malignancy before the development of invasive cancer. Several natural products confer protective effects against a wide range of cancers; examples include grains, nuts, cereals, spices, fruits, vegetables, beverages, medicinal plants, herbs, and their various phytochemical constituents including phenolics, flavonoids, carotenoids, and nitrogen-containing and organosulfur compounds. Phytoestrogens and related compounds act by different mechanisms that ultimately provide benefit with minimum or no side effects and protect and treat different types of cancer, including liver, lung, colon, breast, prostate, esophagus, oral, intestinal, and many other carcinomas.
[Mh] Termos MeSH primário: Anticarcinógenos/uso terapêutico
Neoplasias/prevenção & controle
Fitoestrógenos/uso terapêutico
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anticarcinogenic Agents); 0 (Phytoestrogens)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170829
[St] Status:MEDLINE
[do] DOI:10.1615/CritRevEukaryotGeneExpr.2017019473


  5 / 3212 MEDLINE  
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[PMID]:28812892
[Au] Autor:Dietz BM; Chen SN; Alvarenga RFR; Dong H; Nikolic D; Biendl M; van Breemen RB; Bolton JL; Pauli GF
[Ti] Título:DESIGNER Extracts as Tools to Balance Estrogenic and Chemopreventive Activities of Botanicals for Women's Health.
[So] Source:J Nat Prod;80(8):2284-2294, 2017 Aug 25.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Botanical dietary supplements contain multiple bioactive compounds that target numerous biological pathways. The lack of uniform standardization requirements is one reason that inconsistent clinical effects are reported frequently. The multifaceted biological interactions of active principles can be disentangled by a coupled pharmacological/phytochemical approach using specialized ("knock-out") extracts. This is demonstrated for hops, a botanical for menopausal symptom management. Employing targeted, adsorbent-free countercurrent separation, Humulus lupulus extracts were designed for pre- and postmenopausal women by containing various amounts of the phytoestrogen 8-prenylnaringenin (8-PN) and the chemopreventive constituent xanthohumol (XH). Analysis of their estrogenic (alkaline phosphatase), chemopreventive (NAD(P)H-quinone oxidoreductase 1 [NQO1]), and cytotoxic bioactivities revealed that the estrogenicity of hops is a function of 8-PN, whereas their NQO1 induction and cytotoxic properties depend on XH levels. Antagonization of the estrogenicity of 8-PN by elevated XH concentrations provided evidence for the interdependence of the biological effects. A designed postmenopausal hop extract was prepared to balance 8-PN and XH levels for both estrogenic and chemopreventive properties. An extract designed for premenopausal women contains reduced 8-PN levels and high XH concentrations to minimize estrogenic while retaining chemopreventive properties. This study demonstrates the feasibility of modulating the concentrations of bioactive compounds in botanical extracts for potentially improved efficacy and safety.
[Mh] Termos MeSH primário: Estrogênios/metabolismo
Flavanonas/isolamento & purificação
Flavanonas/farmacologia
Flavonoides/isolamento & purificação
Flavonoides/farmacocinética
Humulus/química
Fitoestrógenos/isolamento & purificação
Fitoestrógenos/farmacologia
Propiofenonas/isolamento & purificação
Propiofenonas/farmacocinética
[Mh] Termos MeSH secundário: Suplementos Nutricionais
Estrogênios/química
Feminino
Flavanonas/química
Flavonoides/química
Seres Humanos
Estrutura Molecular
Fitoestrógenos/química
Propiofenonas/química
Saúde da Mulher
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (8-prenylnaringenin); 0 (Estrogens); 0 (Flavanones); 0 (Flavonoids); 0 (Phytoestrogens); 0 (Propiophenones); T4467YT1NT (xanthohumol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170817
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00284


  6 / 3212 MEDLINE  
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[PMID]:28780881
[Au] Autor:Remport J; Blázovics A
[Ad] Endereço:Farmakognóziai Intézet, Semmelweis Egyetem, Gyógyszerész-tudományi Kar Budapest, Ülloi út 26., 1085.
[Ti] Título:[Phytoestrogens in the treatment of menopause].
[Ti] Título:Fitoösztrogének a menopauza terápiájában..
[So] Source:Orv Hetil;158(32):1243-1251, 2017 Aug.
[Is] ISSN:0030-6002
[Cp] País de publicação:Hungary
[La] Idioma:hun
[Ab] Resumo:In previous centuries many women did not even live until their menopause years due to poor economic conditions, deficiencies of medicine, epidemics and wars. Nowadays in the developed countries, people live until they are 75-80 years old, and with the expansion of average age, the number of people affected by menopause and the years spent in that state increase. Nowadays women spend one third of their lives in the menopausal stage. The only effective way to treat unpleasant symptoms for centuries was with the use of herbs, and the knowledge about them spread through oral tradition. In the 20th century, this therapeutic form was pushed into the background by the development of synthetic drug production and the introduction of hormone replacement therapy. Thanks to the influence of media in the 20th century, women began to have the social need for preserving their beauty and youth for as long as they could. Hormone replacement therapy enjoyed great popularity because women were temporarily relieved of their life quality-impairing menopausal symptoms, but years later it turned out that hormone replacement therapy could pose serious risks. A distinct advantage of herbal therapy is the more advantageous side-effect-profile opposite the used synthetics in hormone replacement therapy. Women are therefore happy to turn to valuable and well-tried natural therapies, which have been used for thousands of years. There is growing interest in herbal remedies. Studying the effects of phytoestrogens has now become an active area for research. However, the results of studies in animals and humans are controversial, some sources suggest that phytoestrogens are effective and safe, other authors claim that they are ineffective in menopause or they have particularly dangerous properties, and cannot be recommended to everyone. It is important to address this issue for the sake of health, mental health and safety of women, and so it is necessary to assess the benefits and the risks before applying them. Orv Hetil. 2017; 158(32): 1243-1251.
[Mh] Termos MeSH primário: Menopausa
Fitoestrógenos/uso terapêutico
Preparações de Plantas/uso terapêutico
Saúde da Mulher
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Phytoestrogens); 0 (Plant Preparations)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170808
[St] Status:MEDLINE
[do] DOI:10.1556/650.2017.30805


  7 / 3212 MEDLINE  
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[PMID]:28768532
[Au] Autor:Zingue S; Michel T; Nde CBM; Njuh AN; Cisilotto J; Ndinteh DT; Clyne C; Fernandez X; Creczynski-Pasa TB; Njamen D
[Ad] Endereço:Department of Life and Earth Sciences, Higher Teachers' Training College, University of Maroua, P.O. Box 55, Maroua, Cameroon. stephanezingue@gmail.com.
[Ti] Título:Estrogen-like and tissue-selective effects of 7-methoxycoumarin from Ficus umbellata (Moraceae): an in vitro and in vivo study.
[So] Source:BMC Complement Altern Med;17(1):383, 2017 Aug 02.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Ficus umbellata is a medicinal plant previously shown to endow estrogenic properties. Its major component was isolated and characterized as 7-methoxycoumarin (MC). Noteworthy, coumarins and the respective active metabolite 7-hydroxycoumarin analogs have shown aromatase inhibitory activity, which is of particular interest in the treatment of estrogen-dependent cancers. The present work aimed at evaluating the estrogenic/antiestrogenic effects of MC in vitro and in vivo. METHODS: To do so, in vitro assays using E-screen and reporter gene were done. In vivo, a 3-day uterotrophic assay followed by a postmenopausal-like rat model to characterize MC as well as F. umbellata aqueous extract in ovariectomized Wistar rats was performed. The investigations focused on histological (vaginal and uterine epithelial height) and morphological (uterine wet weight, vagina stratification and cornification) endpoints, bone mass, biochemical parameters and lipid profile. RESULTS: MC induced a significant (p < 0.05) MCF-7 cell proliferation at a concentration of 0.1 µM, but did not inhibit the effect induced by estradiol in both E-screen and reporter gene assays. In vivo, MC treatment did not show an uterotrophic effect in both rat models used. However, MC (1 mg/kg) induced a significant increase (p < 0.01) of vaginal epithelial height. No significant change was observed with MC in abdominal fat weight, serum lipid levels and bone weight. CONCLUSION: These results suggest that MC has a weak estrogenic activity in vitro and in vivo that accounts only in part to the estrogenicity of the whole plant extract. MC could be beneficial with regard to vagina dryness as it showed a tissue specific effect without exposing the uterus to a potential tumorigenic growth.
[Mh] Termos MeSH primário: Estrogênios/metabolismo
Ficus/química
Fitoestrógenos/farmacologia
Extratos Vegetais/farmacologia
Umbeliferonas/farmacologia
Útero/efeitos dos fármacos
Vagina/efeitos dos fármacos
[Mh] Termos MeSH secundário: Tecido Adiposo/metabolismo
Animais
Inibidores da Aromatase/farmacologia
Osso e Ossos/efeitos dos fármacos
Epitélio/efeitos dos fármacos
Estradiol/metabolismo
Estradiol/farmacologia
Antagonistas de Estrogênios/farmacologia
Feminino
Células HEK293
Seres Humanos
Lipídeos/sangue
Células MCF-7
Ovariectomia
Pós-Menopausa
Ratos Wistar
Útero/metabolismo
Vagina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aromatase Inhibitors); 0 (Estrogen Antagonists); 0 (Estrogens); 0 (Lipids); 0 (Phytoestrogens); 0 (Plant Extracts); 0 (Umbelliferones); 4TI98Z838E (Estradiol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1895-9


  8 / 3212 MEDLINE  
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[PMID]:28720470
[Au] Autor:Dutta S; Kharkar PS; Sahu NU; Khanna A
[Ad] Endereço:Department of Biological Sciences, Sunandan Divatia School of Science, SVKM's NMIMS (deemed-to-be) University, Vile Parle (w), Mumbai 400 056, India.
[Ti] Título:Molecular docking prediction and in vitro studies elucidate anti-cancer activity of phytoestrogens.
[So] Source:Life Sci;185:73-84, 2017 Sep 15.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:AIM: The study is aimed at evaluating the chemosensitization and apoptotic effect of aglycone rich extracts of dietary phytoestrogens (derived from soybean and flaxseed) on estrogen receptor positive, MCF-7 and estrogen receptor negative, MDA-MB-231 cells. The extracts show potent activity on both the cell lines, hence, in silico studies have been carried out to find the possible reason for their activity. MAIN METHODS: MTT assay was carried to assess chemosensitization effect and activated caspase-3/7 activity was studied using flow-cytometry and western blotting. In silico studies were carried out using PharmMapper and the top hits were taken up for docking using the Schrödinger software. Top molecular targets were subjected to gene expression studies by qPCR and protein expression using Western blot analysis. KEY FINDINGS: This study reports the apoptotic activity and chemosensitization effect of the phytoestrogens. Molecular docking studies predict AKR1B1 (aldose reductase), HRAS (Harvey rat sarcoma) and GSTP1 (glutathione s-transferase pi) as potential molecular targets for genistein, daidzein and secoisolariciresinol, respectively. Gene and protein expression studies show down-regulation of AKR1BI, HRAS and GSTP1 by the extracts. SIGNIFICANCE: The qPCR and western blot analysis results support the computational analyses, and hence genistein, daidzein and secoisolariciresinol may be considered as good candidates for future development into potent inhibitors of the respective protein targets through medicinal chemistry optimization.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Apoptose/efeitos dos fármacos
Neoplasias da Mama/tratamento farmacológico
Simulação de Acoplamento Molecular
Fitoestrógenos/farmacologia
[Mh] Termos MeSH secundário: Western Blotting
Neoplasias da Mama/patologia
Butileno Glicóis/farmacologia
Caspase 3/metabolismo
Caspase 7/metabolismo
Linhagem Celular Tumoral
Simulação por Computador
Regulação para Baixo/efeitos dos fármacos
Feminino
Citometria de Fluxo
Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos
Genisteína/farmacologia
Seres Humanos
Isoflavonas/farmacologia
Lignanas/farmacologia
Células MCF-7
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Butylene Glycols); 0 (Isoflavones); 0 (Lignans); 0 (Phytoestrogens); 6287WC5J2L (daidzein); DH2M523P0H (Genistein); EC 3.4.22.- (Caspase 3); EC 3.4.22.- (Caspase 7); M8QRJ7JEJH (secoisolariciresinol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170720
[St] Status:MEDLINE


  9 / 3212 MEDLINE  
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[PMID]:28711487
[Au] Autor:Chen L; Yang Y; Zhang L; Li C; Coffie JW; Geng X; Qiu L; You X; Fang Z; Song M; Gao X; Wang H
[Ad] Endereço:Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin, China; School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
[Ti] Título:Aucubin promotes angiogenesis via estrogen receptor beta in a mouse model of hindlimb ischemia.
[So] Source:J Steroid Biochem Mol Biol;172:149-159, 2017 Sep.
[Is] ISSN:1879-1220
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Aucubin (AU) is an iridoid glycoside that has been shown to display estrogenic properties and has various pharmacological effects. Herein, we described the angiogenic properties of AU. In the study, hindlimb ischemia was induced by ligation of femoral artery on the right leg of ovariectomized mice. AU treatment significantly accelerated perfusion recovery and reduced tissue injury in mice muscle. Quantification of CD31-positive vessels in hindlimb muscles provided evidences that AU promoted angiogenesis in peripheral ischemia. In addition, results from quantitative PCR and western blot suggested AU induced angiogenesis via vascular endothelial cell growth factor (VEGF)/Akt/endothelial nitric oxide synthase (eNOS) signaling pathway. More interestingly, AU's angiogenic effects could be completely abolished in estrogen receptor beta (ERß) knockout mice. In conclusion, the underlying mechanisms were elucidated that AU produced pro-angiogenic effects through ERß-mediated VEGF signaling pathways. These results expand knowledge about the beneficial effects of AU in angiogenesis and blood flow recovery. It might provide insight into the ERß regulating neovascularisation in hindlimb ischemia and identify AU as a potent new compound used for the treatment of peripheral vascular disease.
[Mh] Termos MeSH primário: Indutores da Angiogênese/farmacologia
Receptor beta de Estrogênio/genética
Glucosídeos Iridoides/farmacologia
Isquemia/tratamento farmacológico
Neovascularização Fisiológica/efeitos dos fármacos
Fitoestrógenos/farmacologia
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Receptor beta de Estrogênio/deficiência
Feminino
Artéria Femoral/cirurgia
Regulação da Expressão Gênica
Membro Posterior
Isquemia/genética
Isquemia/patologia
Isquemia/cirurgia
Ligadura
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Óxido Nítrico Sintase Tipo III/genética
Óxido Nítrico Sintase Tipo III/metabolismo
Ovariectomia
Molécula-1 de Adesão Celular Endotelial de Plaquetas/genética
Molécula-1 de Adesão Celular Endotelial de Plaquetas/metabolismo
Proteínas Proto-Oncogênicas c-akt/genética
Proteínas Proto-Oncogênicas c-akt/metabolismo
Recuperação de Função Fisiológica/efeitos dos fármacos
Transdução de Sinais
Fator A de Crescimento do Endotélio Vascular/genética
Fator A de Crescimento do Endotélio Vascular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiogenesis Inducing Agents); 0 (Estrogen Receptor beta); 0 (Iridoid Glucosides); 0 (Phytoestrogens); 0 (Platelet Endothelial Cell Adhesion Molecule-1); 0 (Vascular Endothelial Growth Factor A); 0 (vascular endothelial growth factor A, mouse); 2G52GS8UML (aucubin); EC 1.14.13.39 (Nitric Oxide Synthase Type III); EC 1.14.13.39 (Nos3 protein, mouse); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170717
[St] Status:MEDLINE


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[PMID]:28703650
[Au] Autor:Cobin RH; Goodman NF; AACE Reproductive Endocrinology Scientific Committee
[Ti] Título:AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY POSITION STATEMENT ON MENOPAUSE-2017 UPDATE.
[So] Source:Endocr Pract;23(7):869-880, 2017 Jul.
[Is] ISSN:1530-891X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:EXECUTIVE SUMMARY This American Association of Clinical Endocrinologists (AACE)/American College of Endocrinology (ACE) Position Statement is designed to update the previous menopause clinical practice guidelines published in 2011 but does not replace them. The current document reviews new clinical trials published since then as well as new information regarding possible risks and benefits of therapies available for the treatment of menopausal symptoms. AACE reinforces the recommendations made in its previous guidelines and provides additional recommendations on the basis of new data. A summary regarding this position statement is listed below: New information available from randomized clinical trials and epidemiologic studies reported after 2011 was critically reviewed. No previous recommendations from the 2011 menopause clinical practice guidelines have been reversed or changed. Newer information enhances AACE's guidance for the use of hormone therapy in different subsets of women. Newer information helps to support the use of various types of estrogens, selective estrogen-receptor modulators (SERMs), and progesterone, as well as the route of delivery. Newer information supports the previous recommendation against the use of bioidentical hormones. The use of nonhormonal therapies for the symptomatic relief of menopausal symptoms is supported. Newer information enhances AACE's guidance for the use of hormone therapy in different subsets of women. Newer information helps to support the use of various types of estrogens, SERMs, and progesterone, as well as the route of delivery. Newer information supports the previous recommendation against the use of bioidentical hormones. The use of nonhormonal therapies for the symptomatic relief of menopausal symptoms is supported. New recommendations in this position statement include: 1. RECOMMENDATION: the use of menopausal hormone therapy in symptomatic postmenopausal women should be based on consideration of all risk factors for cardiovascular disease, age, and time from menopause. 2. RECOMMENDATION: the use of transdermal as compared with oral estrogen preparations may be considered less likely to produce thrombotic risk and perhaps the risk of stroke and coronary artery disease. 3. RECOMMENDATION: when the use of progesterone is necessary, micronized progesterone is considered the safer alternative. 4. RECOMMENDATION: in symptomatic menopausal women who are at significant risk from the use of hormone replacement therapy, the use of selective serotonin re-uptake inhibitors and possibly other nonhormonal agents may offer significant symptom relief. 5. RECOMMENDATION: AACE does not recommend use of bioidentical hormone therapy. 6. RECOMMENDATION: AACE fully supports the recommendations of the Comité de l'Évolution des Pratiques en Oncologie regarding the management of menopause in women with breast cancer. 7. RECOMMENDATION: HRT is not recommended for the prevention of diabetes. 8. RECOMMENDATION: In women with previously diagnosed diabetes, the use of HRT should be individualized, taking in to account age, metabolic, and cardiovascular risk factors. ABBREVIATIONS: AACE = American Association of Clinical Endocrinologists; ACE = American College of Endocrinology; BMI = body mass index; CAC = coronary artery calcification; CEE = conjugated equine estrogen; CEPO = Comité de l'Évolution des Pratiques en Oncologie; CAD = coronary artery disease; CIMT = carotid intima media thickness; CVD = cardiovascular disease; FDA = Food and Drug Administration; HDL = high-density lipoprotein; HRT = hormone replacement therapy; HT = hypertension; KEEPS = Kronos Early Estrogen Prevention Study; LDL = low-density lipoprotein; MBS = metabolic syndrome; MPA = medroxyprogesterone acetate; RR = relative risk; SERM = selective estrogen-receptor modulator; SSRI = selective serotonin re-uptake inhibitor; VTE = venous thrombo-embolism; WHI = Women's Health Initiative.
[Mh] Termos MeSH primário: Terapia de Reposição de Estrogênios/métodos
Menopausa
Osteoporose/prevenção & controle
[Mh] Termos MeSH secundário: Administração Cutânea
Administração Oral
Idoso
Aminas/uso terapêutico
Neoplasias da Mama/epidemiologia
Doenças Cardiovasculares/epidemiologia
Cimicifuga
Cognição
Ácidos Cicloexanocarboxílicos/uso terapêutico
Diabetes Mellitus
Endocrinologia
Estradiol/uso terapêutico
Estrogênios/uso terapêutico
Antagonistas de Aminoácidos Excitatórios/uso terapêutico
Feminino
Fogachos
Seres Humanos
Meia-Idade
Fitoestrógenos/uso terapêutico
Fitoterapia
Progesterona/uso terapêutico
Progestinas/uso terapêutico
Medição de Risco
Inibidores da Captação de Serotonina/uso terapêutico
Sociedades Médicas
Trombose/epidemiologia
Sistema Vasomotor
Ácido gama-Aminobutírico/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; PRACTICE GUIDELINE
[Nm] Nome de substância:
0 (Amines); 0 (Cyclohexanecarboxylic Acids); 0 (Estrogens); 0 (Excitatory Amino Acid Antagonists); 0 (Phytoestrogens); 0 (Progestins); 0 (Serotonin Uptake Inhibitors); 4G7DS2Q64Y (Progesterone); 4TI98Z838E (Estradiol); 56-12-2 (gamma-Aminobutyric Acid); 6CW7F3G59X (gabapentin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.4158/EP171828.PS



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