Base de dados : MEDLINE
Pesquisa : D27.505.696.663.050 [Categoria DeCS]
Referências encontradas : 762 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 77 ir para página                         

  1 / 762 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28011746
[Au] Autor:Biaggioni I
[Ad] Endereço:Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University, Nashville, Tennessee italo.biaggioni@vanderbilt.edu.
[Ti] Título:The Pharmacology of Autonomic Failure: From Hypotension to Hypertension.
[So] Source:Pharmacol Rev;69(1):53-62, 2017 Jan.
[Is] ISSN:1521-0081
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Primary neurodegenerative autonomic disorders are characterized clinically by loss of autonomic regulation of blood pressure. The clinical picture is dominated by orthostatic hypotension, but supine hypertension is also a significant problem. Autonomic failure can result from impairment of central autonomic pathways (multiple system atrophy) or neurodegeneration of peripheral postganglionic autonomic fibers (pure autonomic failure, Parkinson's disease). Pharmacologic probes such as the ganglionic blocker trimethaphan can help us in the understanding of the underlying pathophysiology and diagnosis of these disorders. Conversely, understanding the pathophysiology is crucial in the development of effective pharmacotherapy for these patients. Autonomic failure patients provide us with an unfortunate but unique research model characterized by loss of baroreflex buffering. This greatly magnifies the effect of stimuli that would not be apparent in normal subjects. An example of this is the discovery of the osmopressor reflex: ingestion of water increases blood pressure by 30-40 mm Hg in autonomic failure patients. Animal studies indicate that the trigger of this reflex is related to hypo-osmolality in the portal circulation involving transient receptor potential vanilloid 4 receptors. Studies in autonomic failure patients have also revealed that angiotensin II can be generated through noncanonical pathways independent of plasma renin activity to contribute to hypertension. Similarly, the mineralocorticoid receptor antagonist eplerenone produces acute hypotensive effects, highlighting the presence of non-nuclear mineralocorticoid receptor pathways. These are examples of careful clinical research that integrates pathophysiology and pharmacology to advance our knowledge of human disease.
[Mh] Termos MeSH primário: Fármacos do Sistema Nervoso Autônomo/farmacologia
Doenças do Sistema Nervoso Autônomo/fisiopatologia
Sistema Nervoso Autônomo/efeitos dos fármacos
Pressão Sanguínea/efeitos dos fármacos
Fármacos Cardiovasculares/farmacologia
Sistema Cardiovascular/inervação
Hipertensão/fisiopatologia
Hipotensão/fisiopatologia
Neurotransmissores/farmacologia
[Mh] Termos MeSH secundário: Animais
Sistema Nervoso Autônomo/fisiopatologia
Doenças do Sistema Nervoso Autônomo/complicações
Doenças do Sistema Nervoso Autônomo/metabolismo
Barorreflexo/efeitos dos fármacos
Bloqueadores Ganglionares/farmacologia
Seres Humanos
Hipertensão/etiologia
Hipertensão/metabolismo
Hipotensão/etiologia
Hipotensão/metabolismo
Óxido Nítrico/metabolismo
Sistema Renina-Angiotensina/efeitos dos fármacos
Decúbito Dorsal
Simpatomiméticos/farmacologia
Vasoconstritores/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Autonomic Agents); 0 (Cardiovascular Agents); 0 (Ganglionic Blockers); 0 (Neurotransmitter Agents); 0 (Sympathomimetics); 0 (Vasoconstrictor Agents); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161225
[St] Status:MEDLINE
[do] DOI:10.1124/pr.115.012161


  2 / 762 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26706627
[Au] Autor:Davies A; Mundin G; Vriens J; Webber K; Buchanan A; Waghorn M
[Ad] Endereço:Royal Surrey County Hospital, Guildford, Surrey, United Kingdom. Electronic address: adavies12@nhs.net.
[Ti] Título:The Influence of Low Salivary Flow Rates on the Absorption of a Sublingual Fentanyl Citrate Formulation for Breakthrough Cancer Pain.
[So] Source:J Pain Symptom Manage;51(3):538-45, 2016 Mar.
[Is] ISSN:1873-6513
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Salivary gland hypofunction may affect the absorption of drugs through the oral mucosa, which in turn may affect their clinical efficacy (e.g., onset of action). OBJECTIVES: The aim of this study was to assess the pharmacokinetics of a sublingual fentanyl orally disintegrating tablet (Abstral, Prostrakan Inc.) in a group of cancer patients with salivary gland hypofunction. METHODS: Nine cancer patients with salivary gland hypofunction underwent a series of three pharmacokinetic studies with the sublingual fentanyl orally disintegrating tablet. In the first phase, the patients received no pretreatment; in the second phase, the patients were allowed to moisten the oral cavity before dosing; in the third phase, the patients were given pilocarpine hydrochloride (saliva stimulant) before dosing. Fentanyl concentrations were measured using a method of high-performance liquid chromatography with validated tandem mass spectrometric detection. RESULTS: The Tmax was longer, the Cmax was lower, the AUC0-30 lower, and the AUClast lower in the phase involving no pretreatment; the Tmax/Cmax/AUC0-30/AUClast were similar in the phase involving moistening of the oral cavity and the phase involving giving pilocarpine hydrochloride. CONCLUSION: The pharmacokinetics of the sublingual fentanyl orally disintegrating tablet appear to be negatively affected by the presence of salivary gland hypofunction, although the moistening of the oral cavity before dosing results in a pharmacokinetic profile similar to that seen with the giving of pilocarpine hydrochloride.
[Mh] Termos MeSH primário: Analgésicos Opioides/farmacocinética
Dor Irruptiva/tratamento farmacológico
Dor do Câncer/tratamento farmacológico
Fentanila/farmacocinética
Salivação
[Mh] Termos MeSH secundário: Administração Sublingual
Idoso
Analgésicos Opioides/administração & dosagem
Fármacos do Sistema Nervoso Autônomo/administração & dosagem
Dor Irruptiva/fisiopatologia
Dor do Câncer/fisiopatologia
Água Potável/administração & dosagem
Quimioterapia Combinada
Feminino
Fentanila/administração & dosagem
Seres Humanos
Pacientes Internados
Masculino
Meia-Idade
Pilocarpina/administração & dosagem
Glândulas Salivares/efeitos dos fármacos
Glândulas Salivares/fisiopatologia
Salivação/efeitos dos fármacos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Analgesics, Opioid); 0 (Autonomic Agents); 0 (Drinking Water); 01MI4Q9DI3 (Pilocarpine); UF599785JZ (Fentanyl)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170110
[Lr] Data última revisão:
170110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151227
[St] Status:MEDLINE


  3 / 762 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26612784
[Au] Autor:Chien TJ; Liu CY; Ko PH; Hsu CH
[Ad] Endereço:Institute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan Oncology Department, Zhong-Xing Branch, Taipei City Hospital, Taipei, Taiwan.
[Ti] Título:A Chinese Decoction, Kuan-Sin-Yin, Improves Autonomic Function and Cancer-Related Symptoms of Metastatic Colon Cancer.
[So] Source:Integr Cancer Ther;15(1):113-23, 2016 Mar.
[Is] ISSN:1552-695X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Kuan-Sin-Yin (KSY) is a traditional Chinese medicine (TCM) decoction, which has been shown to have cytostatic effects on cancer cells and involved in the TCM theory of promoting yin-yang balance.Sonce many cancer patients suffer from autonomic dysfunction (AD), which correspond to yin-yang imbalance in TCM. The aim of this study is to evaluate the possible effect of KSY in metastatic colon cancer (mCRC) patients with AD. METHODS: We conducted a single-group experiment. Total 52 qualified patients were enrolled. Participants took the KSY daily for 2 weeks. The primary outcome was KSY efficacy as reflected in the heart rate variability (HRV) and electrical conductivity (µA) over 12 meridian points. Autonomic function was examined before and after the KSY intervention. The vagal and sympathetic tone were recorded by HRV; 12 meridian energies were measured using a meridian energy analysis device. Secondary outcomes were cancer-related symptoms and patient quality of life (QoL). RESULTS: The results showed that the KSY intervention improved AD via increasing the vagal tone (HF: P = .041), but not the sympathetic tone (LF: P = .154); total autonomic activity was significantly enhanced (HRV activity: P = .013). Intriguingly, energy increased more over the yin meridian (P = .010) than over the yang meridian (P = .015). Cancer-related symptoms and QoL were significantly improved (P < .05). CONCLUSION: The safety and effectiveness of KSY in improving AD in mCRC patients are through regulating the vagal-sympathetic dynamic balance, which correspond to the TCM yin-yang concept of energy.
[Mh] Termos MeSH primário: Fármacos do Sistema Nervoso Autônomo/uso terapêutico
Doenças do Sistema Nervoso Autônomo/tratamento farmacológico
Neoplasias do Colo/tratamento farmacológico
Medicina Tradicional Chinesa/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Pré-Escolar
Feminino
Frequência Cardíaca/efeitos dos fármacos
Seres Humanos
Lactente
Recém-Nascido
Masculino
Meia-Idade
Qualidade de Vida
Yin-Yang
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Autonomic Agents)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151128
[St] Status:MEDLINE
[do] DOI:10.1177/1534735415617282


  4 / 762 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:25917753
[Au] Autor:Andersson L; Claeson AS; Dantoft TM; Skovbjerg S; Lind N; Nordin S
[Ad] Endereço:Department of Occupational and Public Health Sciences, University of Gävle, Johan Bures Väg 13, 907 36, Umeå, Sweden. linus.andersson@psy.umu.se.
[Ti] Título:Chemosensory perception, symptoms and autonomic responses during chemical exposure in multiple chemical sensitivity.
[So] Source:Int Arch Occup Environ Health;89(1):79-88, 2016 Jan.
[Is] ISSN:1432-1246
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Multiple chemical sensitivity (MCS) is a prevalent medically unexplained symptom characterized by symptom reactions to everyday chemical exposure below hygienic thresholds. The aim of this study was to investigate the expressions of hyper-reactivity in MCS during whole-body exposure to low concentrations of the odorant n-butanol. METHODS: We exposed 18 participants with MCS and 18 non-ill controls to a low concentration of the odorant n-butanol using an exposure chamber. The first 10 min constituted blank exposure, after which the n-butanol concentration increased and reached a plateau at 11.5 mg/m(3). RESULTS: MCS participants, compared with controls, reported greater perceived odor intensities, more unpleasantness to the exposure and increasing symptoms over time. MCS participants also expressed higher pulse rate and lower pulse rate variability than controls did. No group differences were found for breathing rate or tonic electrodermal activity responses. CONCLUSIONS: We conclude that MCS sufferers differ from healthy controls in terms of autonomic responses, symptoms and chemosensory perception during chemical exposure.
[Mh] Termos MeSH primário: 1-Butanol/farmacologia
Fármacos do Sistema Nervoso Autônomo/farmacologia
Sistema Nervoso Autônomo/efeitos dos fármacos
Sensibilidade Química Múltipla/fisiopatologia
Percepção Olfatória/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adulto
Sistema Nervoso Autônomo/fisiopatologia
Feminino
Frequência Cardíaca/efeitos dos fármacos
Seres Humanos
Exposição por Inalação/efeitos adversos
Masculino
Meia-Idade
Odorantes
Limiar Sensorial/efeitos dos fármacos
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Autonomic Agents); 8PJ61P6TS3 (1-Butanol)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150429
[St] Status:MEDLINE
[do] DOI:10.1007/s00420-015-1053-y


  5 / 762 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:26354022
[Au] Autor:Saqib F; Ahmed MG; Janbaz KH; Dewanjee S; Jaafar HZ; Zia-Ul-Haq M
[Ad] Endereço:Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan. fatima2saqib@yahoo.com.
[Ti] Título:Validation of ethnopharmacological uses of Murraya paniculata in disorders of diarrhea, asthma and hypertension.
[So] Source:BMC Complement Altern Med;15:319, 2015 Sep 09.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Murraya paniculata is traditionally used for management of gut, air way and cardiovascular disorders. The study was conducted for provision of pharmacological rationalization for folkloric uses of Murraya paniculata in gut, air way and cardiovascular problems. METHODS: Aqueous-ethanolic extract of Mp.Cr was tested using in vitro techniques on isolated tissue of rabbit (jejunum, trachea and aorta) to detect the possible presence of spasmolytic activity. The responses of tissues were recorded using isotonic transducers coupled with PowerLab data acquisition system. RESULTS: Application of the extract of Mp.Cr relaxed spontaneous and high K(+) (80mM)-induced contraction in rabbit jejunum preparation. Because it shifted the CRCs (Calcium response curve) towards the right side so the possible blockade was of calcium channel similar to verapamil. In rabbit trachea, extract of Mp.Cr produced relaxation of carbachol and high K(+) induced contractions. When plant extract was checked further on isolated aorta for its possible vasodilator effect, it caused relaxation of phenylephrine and high K(+)-induced spastic contractions at different doses. CONCLUSION: These results indicate that Murraya paniculata shows anti-spasmodic, bronchodilator and vasodilator activity facilitated through Ca(++) antagonist mechanisms.
[Mh] Termos MeSH primário: Asma/metabolismo
Fármacos do Sistema Nervoso Autônomo/farmacologia
Diarreia/metabolismo
Hipertensão/metabolismo
Murraya/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Aorta/efeitos dos fármacos
Etnofarmacologia
Jejuno/efeitos dos fármacos
Modelos Biológicos
Coelhos
Traqueia/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Autonomic Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150913
[Lr] Data última revisão:
150913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150911
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-015-0837-7


  6 / 762 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:25955253
[Au] Autor:Krabs RU; Enk R; Teich N; Koelsch S
[Ad] Endereço:Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
[Ti] Título:Autonomic effects of music in health and Crohn's disease: the impact of isochronicity, emotional valence, and tempo.
[So] Source:PLoS One;10(5):e0126224, 2015.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Music can evoke strong emotions and thus elicit significant autonomic nervous system (ANS) responses. However, previous studies investigating music-evoked ANS effects produced inconsistent results. In particular, it is not clear (a) whether simply a musical tactus (without common emotional components of music) is sufficient to elicit ANS effects; (b) whether changes in the tempo of a musical piece contribute to the ANS effects; (c) whether emotional valence of music influences ANS effects; and (d) whether music-elicited ANS effects are comparable in healthy subjects and patients with Crohn´s disease (CD, an inflammatory bowel disease suspected to be associated with autonomic dysfunction). METHODS: To address these issues, three experiments were conducted, with a total of n = 138 healthy subjects and n = 19 CD patients. Heart rate (HR), heart rate variability (HRV), and electrodermal activity (EDA) were recorded while participants listened to joyful pleasant music, isochronous tones, and unpleasant control stimuli. RESULTS: Compared to silence, both pleasant music and unpleasant control stimuli elicited an increase in HR and a decrease in a variety of HRV parameters. Surprisingly, similar ANS effects were elicited by isochronous tones (i.e., simply by a tactus). ANS effects did not differ between pleasant and unpleasant stimuli, and different tempi of the music did not entrain ANS activity. Finally, music-evoked ANS effects did not differ between healthy individuals and CD patients. CONCLUSIONS: The isochronous pulse of music (i.e., the tactus) is a major factor of music-evoked ANS effects. These ANS effects are characterized by increased sympathetic activity. The emotional valence of a musical piece contributes surprisingly little to the ANS activity changes evoked by that piece.
[Mh] Termos MeSH primário: Doença de Crohn/psicologia
Emoções/fisiologia
Música/psicologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Fármacos do Sistema Nervoso Autônomo
Sistema Nervoso Autônomo/fisiologia
Doença de Crohn/fisiopatologia
Eletrocardiografia
Feminino
Frequência Cardíaca/fisiologia
Seres Humanos
Masculino
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Autonomic Agents)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150509
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0126224


  7 / 762 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:25791260
[Au] Autor:Milazzo V; Di Stefano C; Milan A; Ravera A; Sobrero G; Sabia L; Veglio F; Maule S
[Ad] Endereço:Autonomic Unit and Hypertension Unit, Department of Medical Sciences, University of Torino, Torino, Italy, valeriamilazzo85@gmail.com.
[Ti] Título:Cardiovascular complications in patients with autonomic failure.
[So] Source:Clin Auton Res;25(3):133-40, 2015 Jun.
[Is] ISSN:1619-1560
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Patients with autonomic failure are characterized by orthostatic hypotension, supine hypertension, high blood pressure variability, blunted heart rate variability, and often have a "non-dipping" or "reverse dipping" pattern on 24-h ambulatory blood pressure monitoring. These alterations may lead to cardiovascular and cerebrovascular changes, similar to the target organ damage found in hypertension. Often patients with autonomic failure are on treatment with anti-hypotensive drugs, which may worsen supine hypertension. The aim of this review is to summarize the evidence for cardiac, vascular, renal, and cerebrovascular damage in patients with autonomic failure.
[Mh] Termos MeSH primário: Doenças Cardiovasculares/etiologia
Insuficiência Autonômica Pura/complicações
[Mh] Termos MeSH secundário: Fármacos do Sistema Nervoso Autônomo/efeitos adversos
Fármacos do Sistema Nervoso Autônomo/uso terapêutico
Pressão Sanguínea/fisiologia
Doenças Cardiovasculares/patologia
Seres Humanos
Insuficiência Autonômica Pura/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Autonomic Agents)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:171014
[Lr] Data última revisão:
171014
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150321
[St] Status:MEDLINE
[do] DOI:10.1007/s10286-015-0275-0


  8 / 762 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:25623383
[Au] Autor:Sfrantzis KD; How JM; Sartor DM
[Ad] Endereço:Department of Medicine, Austin Health, University of Melbourne, Heidelberg, 3084 Victoria, Australia.
[Ti] Título:Implications of diet modification on sympathoinhibitory mechanisms and hypertension in obesity.
[So] Source:Auton Neurosci;189:25-30, 2015 May.
[Is] ISSN:1872-7484
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:We have previously demonstrated that a number of rats fed a moderately high-fat diet (MHFD) become obese and hypertensive and had compromised sympathoinhibitory and vasodilator responses to the gut hormones cholecystokinin (CCK) and gastric leptin. This has implications for increased resistance in vascular beds that attract a large proportion of cardiac output after a meal and may be an important mechanism underlying the development of hypertension in obesity in which food consumption is greatly increased. The aim of this study was to determine whether swapping a MHFD for a low-fat diet (LFD) would induce weight loss in obese animals, reverse the signs of hypertension and restore sympathoinhibitory reflexes. Male Sprague-Dawley rats were placed on a LFD (controls; n = 8) or a MHFD (n = 24) for 11 weeks after which the latter displayed either an obesity-prone (OP) or obesity-resistant (OR) phenotype. All animals were fed a LFD for a further 6 weeks after which they were anaesthetised with isoflurane and artificially ventilated for evaluation of resting arterial pressure (AP) and renal sympathetic nerve responses to CCK (0.1-4 µg/kg) and leptin (15 µg/kg). Weight gain in OP animals remained higher than OR or controls following diet switch (P < 0.05 for both). Resting AP was not significantly different between OP (103 ± 4 mmHg), OR (102 ± 3 mmHg) or control (104 ± 3 mmHg) animals and sympathoinhibitory responses to CCK or leptin were not different between the groups (P > 0.05). These results demonstrate that diet modification can have beneficial effects on sympathetic function and restore normotension without the need for weight reduction.
[Mh] Termos MeSH primário: Dieta com Restrição de Gorduras
Hipertensão/dietoterapia
Hipertensão/fisiopatologia
Obesidade/dietoterapia
Obesidade/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Pressão Arterial/fisiologia
Fármacos do Sistema Nervoso Autônomo/farmacologia
Peso Corporal
Colecistocinina/farmacologia
Dieta Hiperlipídica/efeitos adversos
Modelos Animais de Doenças
Fármacos Gastrointestinais/farmacologia
Predisposição Genética para Doença
Leptina/farmacologia
Masculino
Ratos Sprague-Dawley
Sistema Nervoso Simpático/efeitos dos fármacos
Sistema Nervoso Simpático/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Autonomic Agents); 0 (Gastrointestinal Agents); 0 (Leptin); 9011-97-6 (Cholecystokinin)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:150330
[Lr] Data última revisão:
150330
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150128
[St] Status:MEDLINE


  9 / 762 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:25549851
[Au] Autor:Ando K; Kondo F; Yamaguchi N; Tachi M; Fukayama M; Yoshikawa K; Gosho M; Fujiwara Y; Okada S
[Ad] Endereço:Department of Anesthesiology, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan.
[Ti] Título:Centrally administered isoproterenol induces sympathetic outflow via brain prostaglandin E2-mediated mechanisms in rats.
[So] Source:Auton Neurosci;189:1-7, 2015 May.
[Is] ISSN:1872-7484
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Brain ß-adrenoceptor stimulation can induce elevations of plasma levels of noradrenaline. However, there have been no detailed studies related to signaling pathways downstream of ß-adrenoceptors responsible for central sympathetic outflow. In the present study, we pharmacologically examined the possibility that centrally administered isoproterenol can induce elevations of plasma noradrenaline levels in a brain prostaglandin-dependent manner. In addition, we also examined whether or not intracerebroventricular administration of isoproterenol could release endogenously synthesized prostaglandin (PG) E2 in the hypothalamic paraventricular nucleus (PVN) by using the brain microdialysis technique combined with liquid chromatography-ion trap tandem mass spectrometry (LC-ITMS(n)). Under urethane anesthesia, a femoral venous line was inserted for infusion of saline and a femoral arterial line was inserted for collecting blood samples. Next, animals were placed in a stereotaxic apparatus for application of test agents. Catecholamines in the plasma were extracted by alumina absorption and were assayed by high-performance liquid chromatography with electrochemical detection. Quantification of PGE2 in rat PVN microdialysates was performed by the LC-ITMS(n) method. We demonstrated that centrally administered isoproterenol-induced elevations of plasma noradrenaline could be mediated via activation of ß-adrenoceptors and the downstream phospholipase A2-cyclooxygenase pathway. Furthermore, PGE2 in the PVN and the PGE2 receptor EP3 subtype appear to play an important role in the process. Our results suggest that central isoproterenol-induced sympathetic outflow is mediated via brain PGE2 in a PGE2 receptor EP3 subtype-dependent manner.
[Mh] Termos MeSH primário: Fármacos do Sistema Nervoso Autônomo/administração & dosagem
Dinoprostona/metabolismo
Isoproterenol/administração & dosagem
Núcleo Hipotalâmico Paraventricular/efeitos dos fármacos
Núcleo Hipotalâmico Paraventricular/metabolismo
[Mh] Termos MeSH secundário: Antagonistas Adrenérgicos beta/farmacologia
Animais
Cromatografia Líquida de Alta Pressão
Inibidores de Ciclo-Oxigenase/farmacologia
Masculino
Microdiálise
Norepinefrina/sangue
Inibidores de Fosfolipase A2/farmacologia
Fosfolipases A2/metabolismo
Prostaglandina-Endoperóxido Sintases/metabolismo
Ratos Wistar
Receptores Adrenérgicos beta/metabolismo
Receptores de Prostaglandina E Subtipo EP3/antagonistas & inibidores
Receptores de Prostaglandina E Subtipo EP3/metabolismo
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Adrenergic beta-Antagonists); 0 (Autonomic Agents); 0 (Cyclooxygenase Inhibitors); 0 (Phospholipase A2 Inhibitors); 0 (Receptors, Adrenergic, beta); 0 (Receptors, Prostaglandin E, EP3 Subtype); EC 1.14.99.1 (Prostaglandin-Endoperoxide Synthases); EC 3.1.1.4 (Phospholipases A2); K7Q1JQR04M (Dinoprostone); L628TT009W (Isoproterenol); X4W3ENH1CV (Norepinephrine)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:150330
[Lr] Data última revisão:
150330
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150101
[St] Status:MEDLINE


  10 / 762 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:25533534
[Au] Autor:Kawai N; Sakai N; Okuro M; Karakawa S; Tsuneyoshi Y; Kawasaki N; Takeda T; Bannai M; Nishino S
[Ad] Endereço:Institute for Innovation, Ajinomoto Co., Inc., Kawasaki, Japan.
[Ti] Título:The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus.
[So] Source:Neuropsychopharmacology;40(6):1405-16, 2015 May.
[Is] ISSN:1740-634X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The use of glycine as a therapeutic option for improving sleep quality is a novel and safe approach. However, despite clinical evidence of its efficacy, the details of its mechanism remain poorly understood. In this study, we investigated the site of action and sleep-promoting mechanisms of glycine in rats. In acute sleep disturbance, oral administration of glycine-induced non-rapid eye movement (REM) sleep and shortened NREM sleep latency with a simultaneous decrease in core temperature. Oral and intracerebroventricular injection of glycine elevated cutaneous blood flow (CBF) at the plantar surface in a dose-dependent manner, resulting in heat loss. Pretreatment with N-methyl-D-aspartate (NMDA) receptor antagonists AP5 and CGP78608 but not the glycine receptor antagonist strychnine inhibited the CBF increase caused by glycine injection into the brain. Induction of c-Fos expression was observed in the hypothalamic nuclei, including the medial preoptic area (MPO) and the suprachiasmatic nucleus (SCN) shell after glycine administration. Bilateral microinjection of glycine into the SCN elevated CBF in a dose-dependent manner, whereas no effect was observed when glycine was injected into the MPO and dorsal subparaventricular zone. In addition, microinjection of D-serine into the SCN also increased CBF, whereas these effects were blocked in the presence of L-701324. SCN ablation completely abolished the sleep-promoting and hypothermic effects of glycine. These data suggest that exogenous glycine promotes sleep via peripheral vasodilatation through the activation of NMDA receptors in the SCN shell.
[Mh] Termos MeSH primário: Fármacos do Sistema Nervoso Autônomo/farmacologia
Glicina/farmacologia
Hipnóticos e Sedativos/farmacologia
Receptores de N-Metil-D-Aspartato/metabolismo
Núcleo Supraquiasmático/efeitos dos fármacos
Núcleo Supraquiasmático/metabolismo
[Mh] Termos MeSH secundário: Animais
Temperatura Corporal/efeitos dos fármacos
Temperatura Corporal/fisiologia
Relação Dose-Resposta a Droga
Masculino
Área Pré-Óptica/efeitos dos fármacos
Área Pré-Óptica/metabolismo
Proteínas Proto-Oncogênicas c-fos/metabolismo
Distribuição Aleatória
Ratos Sprague-Dawley
Ratos Wistar
Receptores da Glicina/agonistas
Receptores da Glicina/antagonistas & inibidores
Receptores da Glicina/metabolismo
Receptores de N-Metil-D-Aspartato/antagonistas & inibidores
Fluxo Sanguíneo Regional/efeitos dos fármacos
Fluxo Sanguíneo Regional/fisiologia
Pele/irrigação sanguínea
Pele/efeitos dos fármacos
Sono/efeitos dos fármacos
Sono/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Autonomic Agents); 0 (Hypnotics and Sedatives); 0 (Proto-Oncogene Proteins c-fos); 0 (Receptors, Glycine); 0 (Receptors, N-Methyl-D-Aspartate); TE7660XO1C (Glycine)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141224
[St] Status:MEDLINE
[do] DOI:10.1038/npp.2014.326



página 1 de 77 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde