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[PMID]:29273526
[Au] Autor:Stueber T; Meyer S; Jangra A; Hage A; Eberhardt M; Leffler A
[Ad] Endereço:Department of Anaesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany.
[Ti] Título:Activation of the capsaicin-receptor TRPV1 by the acetaminophen metabolite N-arachidonoylaminophenol results in cytotoxicity.
[So] Source:Life Sci;194:67-74, 2018 Feb 01.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:AIMS: The anandamide reuptake inhibitor N-arachidonoylaminophenol (AM404) and the reactive substance N-acetyl-p-benzoquinone imine (NAPQI) are both metabolites of acetaminophen and may contribute to acetaminophen-induced analgesia by acting at TRPV1 expressed in the peripheral or central nervous system. While NAPQI slowly sensitizes and activates TRPV1 by interacting with distinct intracellular cysteine residues, detailed properties of AM404 as an agonist of TRPV1 have not yet been reported on. We explored the effects of AM404 on recombinant human TRPV1 and in rodent dorsal root ganglion (DRG) neurons. MATERIALS AND METHODS: HEK 293 cells expressing different isoforms of recombinant TRPV1 and rodent DRG neurons were employed for patch clamp and calcium imaging experiments. Cytotoxicity was assessed by propidium iodide and Annexin V staining on TRPV1-HEK 293 cells and with trypan blue staining on DRG neurons. KEY FINDINGS: AM404 activates hTRPV1 at concentrations >1µM and in a concentration-dependent manner. AM404 also potentiates TRPV1-mediated currents evoked by heat and anandamide. Moreover, AM404-evoked currents are potentiated by NAPQI. While the partly capsaicin-insensitive rabbit (o) TRPV1 fails to respond to AM404, AM404-sensitivity is restored by insertion of the capsaicin binding-domain of rat TRPV1 into oTRPV1. In DRG neurons, AM404-evoked calcium influx as well as cell death is mediated by TRPV1. SIGNIFICANCE: AM404 gates TRPV1 by interacting with the vanilloid-binding site, and TRPV1 is the main receptor for AM404 in DRG neurons. While direct activation of TRPV1 requires high concentrations of AM404, it is possible that synergistic effects of AM404 with further TRPV1-agonists may occur at clinically relevant concentrations.
[Mh] Termos MeSH primário: Acetaminofen/farmacologia
Analgésicos não Entorpecentes/farmacologia
Ácidos Araquidônicos/farmacologia
Gânglios Espinais/efeitos dos fármacos
Canais de Cátion TRPV/metabolismo
[Mh] Termos MeSH secundário: Acetaminofen/metabolismo
Analgesia
Analgésicos não Entorpecentes/metabolismo
Animais
Ácidos Araquidônicos/metabolismo
Benzoquinonas/metabolismo
Capsaicina/farmacologia
Gânglios Espinais/citologia
Células HEK293
Seres Humanos
Iminas/metabolismo
Camundongos Endogâmicos C57BL
Neurônios/efeitos dos fármacos
Neurônios/metabolismo
Coelhos
Ratos Sprague-Dawley
Fármacos do Sistema Sensorial/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Non-Narcotic); 0 (Arachidonic Acids); 0 (Benzoquinones); 0 (Imines); 0 (Sensory System Agents); 0 (TRPV Cation Channels); 0 (TRPV1 protein, human); 362O9ITL9D (Acetaminophen); G6S9BN13TI (N-acetyl-4-benzoquinoneimine); S07O44R1ZM (Capsaicin); XVJ94H0U21 (N-(4-hydroxyphenyl)arachidonylamide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171224
[St] Status:MEDLINE


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[PMID]:28767579
[Au] Autor:Liu SC; Lu HH; Fan HC; Wang HW; Chen HK; Lee FP; Yu CJ; Chu YH
[Ad] Endereço:aDepartment of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center bGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University cDepartment of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University dDepartment of Pediatrics, Tungs' Taichung Metro Harbor Hospital eDepartment of Otolaryngology-Head and Neck Surgery, Shuang Ho Hospital, Taipei, Taiwan, Republic of China.
[Ti] Título:The identification of the TRPM8 channel on primary culture of human nasal epithelial cells and its response to cooling.
[So] Source:Medicine (Baltimore);96(31):e7640, 2017 Aug.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: It has been proposed that the transient receptor potential (TRP) channel Melastatin 8 (TRPM8) is a cold-sensing TRP channel. However, its presence and its role in the nasal cavity have not yet been fully studied. METHODS: Immunohistology was used to study TRPM8 receptors in both the nasal mucosa tissue and the primary cultures of human nasal cells. Cells from primary cultures were immunostained with antibodies to TRPM8, mucin, cytokeratin (CK)-14, CK-18, and vimentin. Western blotting and real-time polymerase chain reaction (PCR) were used to determine the physiological role of TRPM8 in mucus production in the nasal cavity, with and without its agonist and antagonist. RESULTS: The TRPM8 is clearly present in the epithelium, mucous glands, and vessels. No obvious TRPM8-immunoreactive cells were detected in the connective tissue. Immunostaining of cytospin preparations showed that epithelial cells test positive for CK-14, CK-18, TRPM8, and mucin 5AC (MUC5AC). Fibroblastic cells are stained negative for TRPM8. Secreted mucins in the cultured supernatant are detected after exposure to menthol and moderate cooling to 24°C. Both induce a statistically significant increase in the level of MUC5AC mRNA and mucin production. BCTC, a TRPM8 antagonist, has a statistically significant inhibitory effect on MUC5AC mRNA expression and MUC5AC protein production that is induced by menthol and moderate cooling to 24°C. CONCLUSIONS: The study demonstrates that TRPM8 is present in the nasal epithelium. When it is activated by moderate cooling to 24°C or menthol, TRPM8 induces the secretion of mucin. This study shows that TRPM8 channels are important regulators of mucin production. Therefore, TRPM8 antagonists could be used to treat refractory rhinitis.
[Mh] Termos MeSH primário: Temperatura Baixa
Células Epiteliais/metabolismo
Mucosa Nasal/metabolismo
Canais de Cátion TRPM/metabolismo
[Mh] Termos MeSH secundário: Western Blotting
Células Cultivadas
Células Epiteliais/citologia
Células Epiteliais/efeitos dos fármacos
Feminino
Fibroblastos/citologia
Fibroblastos/efeitos dos fármacos
Fibroblastos/metabolismo
Seres Humanos
Imuno-Histoquímica
Queratina-14/metabolismo
Queratina-18/metabolismo
Masculino
Mentol/farmacologia
Mucina-5AC/metabolismo
Mucosa Nasal/citologia
Mucosa Nasal/efeitos dos fármacos
Pirazinas/farmacologia
Piridinas/farmacologia
RNA Mensageiro/metabolismo
Reação em Cadeia da Polimerase em Tempo Real
Fármacos do Sistema Sensorial/farmacologia
Canais de Cátion TRPM/antagonistas & inibidores
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Keratin-14); 0 (Keratin-18); 0 (MUC5AC protein, human); 0 (Mucin 5AC); 0 (N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide); 0 (Pyrazines); 0 (Pyridines); 0 (RNA, Messenger); 0 (Sensory System Agents); 0 (TRPM Cation Channels); 0 (TRPM8 protein, human); 1490-04-6 (Menthol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007640


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[PMID]:28637786
[Au] Autor:Kadekawa K; Majima T; Shimizu T; Wada N; de Groat WC; Kanai AJ; Goto M; Yoshiyama M; Sugaya K; Yoshimura N
[Ad] Endereço:Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
[Ti] Título:The role of capsaicin-sensitive C-fiber afferent pathways in the control of micturition in spinal-intact and spinal cord-injured mice.
[So] Source:Am J Physiol Renal Physiol;313(3):F796-F804, 2017 Sep 01.
[Is] ISSN:1522-1466
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We examined bladder and urethral sphincter activity in mice with or without spinal cord injury (SCI) after C-fiber afferent desensitization induced by capsaicin pretreatment and changes in electrophysiological properties of mouse bladder afferent neurons 4 wk after SCI. Female C57BL/6N mice were divided into four groups: ) spinal intact (SI)-control, ) SI-capsaicin pretreatment (Cap), ) SCI-control, and ) SCI-Cap groups. Continuous cystometry and external urethral sphincter (EUS)-electromyogram (EMG) were conducted under an awake condition. In the Cap groups, capsaicin (25, 50, or 100 mg/kg) was injected subcutaneously 4 days before the experiments. In the SI-Cap group, 100 mg/kg capsaicin pretreatment significantly increased bladder capacity and decreased the silent period duration of EUS/EMG compared with the SI-control group. In the SCI-Cap group, 50 and 100 mg/kg capsaicin pretreatment decreased the number of nonvoiding contractions (NVCs) and the duration of reduced EUS activity during voiding, respectively, compared with the SCI-control group. In SCI mice, hexamethonium, a ganglionic blocker, almost completely blocked NVCs, suggesting that they are of neurogenic origin. Patch-clamp recordings in capsaicin-sensitive bladder afferent neurons from SCI mice showed hyperexcitability, which was evidenced by decreased spike thresholds and increased firing rate compared with SI mice. These results indicate that capsaicin-sensitive C-fiber afferent pathways, which become hyperexcitable after SCI, can modulate bladder and urethral sphincter activity in awake SI and SCI mice. Detrusor overactivity as shown by NVCs in SCI mice is significantly but partially dependent on capsaicin-sensitive C-fiber afferents, whereas the EUS relaxation during voiding is enhanced by capsaicin-sensitive C-fiber bladder afferents in SI and SCI mice.
[Mh] Termos MeSH primário: Capsaicina/farmacologia
Fibras Nervosas Amielínicas/efeitos dos fármacos
Neurônios Aferentes/efeitos dos fármacos
Fármacos do Sistema Sensorial/farmacologia
Traumatismos da Medula Espinal/tratamento farmacológico
Uretra/inervação
Bexiga Urinária Hiperativa/prevenção & controle
Bexiga Urinária/inervação
Micção/efeitos dos fármacos
[Mh] Termos MeSH secundário: Potenciais de Ação
Animais
Modelos Animais de Doenças
Eletromiografia
Feminino
Bloqueadores Ganglionares/farmacologia
Camundongos Endogâmicos C57BL
Fibras Nervosas Amielínicas/metabolismo
Neurônios Aferentes/metabolismo
Técnicas de Patch-Clamp
Pressão
Traumatismos da Medula Espinal/complicações
Traumatismos da Medula Espinal/fisiopatologia
Fatores de Tempo
Bexiga Urinária Hiperativa/etiologia
Bexiga Urinária Hiperativa/fisiopatologia
Urodinâmica/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ganglionic Blockers); 0 (Sensory System Agents); S07O44R1ZM (Capsaicin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.1152/ajprenal.00097.2017


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[PMID]:28494183
[Au] Autor:Dezieck L; Hafez Z; Conicella A; Blohm E; O'Connor MJ; Schwarz ES; Mullins ME
[Ad] Endereço:a Department of Emergency Medicine , University of Massachusetts Medical School , Worcester , MA , USA.
[Ti] Título:Resolution of cannabis hyperemesis syndrome with topical capsaicin in the emergency department: a case series.
[So] Source:Clin Toxicol (Phila);55(8):908-913, 2017 Sep.
[Is] ISSN:1556-9519
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cannabinoid hyperemesis syndrome (CHS) is characterized by symptoms of cyclic abdominal pain, nausea, and vomiting in the setting of prolonged cannabis use. The transient receptor potential vanilloid 1 (TRPV1) receptor may be involved in this syndrome. Topical capsaicin is a proposed treatment for CHS; it binds TRPV1 with high specificity, impairing substance P signaling in the area postrema and nucleus tractus solitarius via overstimulation of TRPV1. This may explain its apparent antiemetic effect in this syndrome. PURPOSE: We describe a series of thirteen cases of suspected cannabis hyperemesis syndrome treated with capsaicin in the emergency departments of two academic medical centers. METHODS: A query of the electronic health record at both centers identified thirteen patients with documented daily cannabis use and symptoms consistent with CHS who were administered topical capsaicin cream for symptom management. RESULTS: All 13 patients experienced symptom relief after administration of capsaicin cream. CONCLUSION: Topical capsaicin was associated with improvement in symptoms of CHS after other treatments failed.
[Mh] Termos MeSH primário: Dor Abdominal/tratamento farmacológico
Antieméticos/administração & dosagem
Capsaicina/administração & dosagem
Serviço Hospitalar de Emergência
Abuso de Maconha/complicações
Fumar Maconha/efeitos adversos
Náusea/tratamento farmacológico
Fármacos do Sistema Sensorial/administração & dosagem
Vômito/tratamento farmacológico
[Mh] Termos MeSH secundário: Dor Abdominal/diagnóstico
Dor Abdominal/etiologia
Dor Abdominal/metabolismo
Adulto
Antieméticos/efeitos adversos
Área Postrema/efeitos dos fármacos
Área Postrema/metabolismo
Capsaicina/efeitos adversos
Registros Eletrônicos de Saúde
Feminino
Seres Humanos
Masculino
Massachusetts
Meia-Idade
Missouri
Náusea/diagnóstico
Náusea/etiologia
Náusea/metabolismo
Estudos Retrospectivos
Fármacos do Sistema Sensorial/efeitos adversos
Núcleo Solitário/efeitos dos fármacos
Núcleo Solitário/metabolismo
Síndrome
Canais de Cátion TRPV/antagonistas & inibidores
Canais de Cátion TRPV/metabolismo
Resultado do Tratamento
Vômito/diagnóstico
Vômito/etiologia
Vômito/metabolismo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Antiemetics); 0 (Sensory System Agents); 0 (TRPV Cation Channels); 0 (TRPV1 protein, human); S07O44R1ZM (Capsaicin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE
[do] DOI:10.1080/15563650.2017.1324166


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[PMID]:28431564
[Au] Autor:Mankowski C; Poole CD; Ernault E; Thomas R; Berni E; Currie CJ; Treadwell C; Calvo JI; Plastira C; Zafeiropoulou E; Odeyemi I
[Ad] Endereço:Astellas Pharma Europe Ltd, 2000 Hillswood Drive, Chertsey, KT16 0PS, UK.
[Ti] Título:Effectiveness of the capsaicin 8% patch in the management of peripheral neuropathic pain in European clinical practice: the ASCEND study.
[So] Source:BMC Neurol;17(1):80, 2017 Apr 21.
[Is] ISSN:1471-2377
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In randomised studies, the capsaicin 8% patch has demonstrated effective pain relief in patients with peripheral neuropathic pain (PNP) arising from different aetiologies. METHODS: ASCEND was an open-label, non-interventional study of patients with non-diabetes-related PNP who received capsaicin 8% patch treatment, according to usual clinical practice, and were followed for ≤52 weeks. Co-primary endpoints were percentage change in the mean numeric pain rating scale (NPRS) 'average daily pain' score from baseline to the average of Weeks 2 and 8 following first treatment; and median time from first to second treatment. The primary analysis was intended to assess analgesic equivalence between post-herpetic neuralgia (PHN) and other PNP aetiologies. Health-related quality of life (HRQoL, using EQ-5D), Patient Global Impression of Change (PGIC) and tolerability were also assessed. RESULTS: Following first application, patients experienced a 26.6% (95% CI: 23.6, 29.62; n = 412) reduction in mean NPRS score from baseline to Weeks 2 and 8. Equivalence was demonstrated between PHN and the neuropathic back pain, post-operative and post-traumatic neuropathic pain and 'other' PNP aetiology subgroups. The median time from first to second treatment was 191 days (95% CI: 147, 235; n = 181). Forty-four percent of all patients were responders (≥30% reduction in NPRS score from baseline to Weeks 2 and 8) following first treatment, and 86.9% (n = 159/183) remained so at Week 12. A sustained pain response was observed until Week 52, with a 37.0% (95% CI: 31.3, 42.7; n = 176) reduction in mean NPRS score from baseline. Patients with the shortest duration of pain (0-0.72 years) experienced the highest pain response from baseline to Weeks 2 and 8. Mean EQ-5D index score improved by 0.199 utils (responders: 0.292 utils) from baseline to Week 2 and was maintained until Week 52. Most patients reported improvements in PGIC at Week 2 and at all follow-up assessments regardless of number of treatments received. Adverse events were primarily mild or moderate reversible application site reactions. CONCLUSION: In European clinical practice, the capsaicin 8% patch provided effective and sustained pain relief, substantially improved HRQoL, improved overall health status and was generally well tolerated in a heterogeneous PNP population. TRIAL REGISTRATION: NCT01737294 Date of registration - October 22, 2012.
[Mh] Termos MeSH primário: Analgésicos/administração & dosagem
Capsaicina/administração & dosagem
Neuralgia/tratamento farmacológico
Fármacos do Sistema Sensorial/administração & dosagem
[Mh] Termos MeSH secundário: Adulto
Analgésicos/efeitos adversos
Capsaicina/efeitos adversos
Feminino
Seres Humanos
Masculino
Meia-Idade
Manejo da Dor
Medição da Dor
Qualidade de Vida
Fármacos do Sistema Sensorial/efeitos adversos
Adesivo Transdérmico
Resultado do Tratamento
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Sensory System Agents); S07O44R1ZM (Capsaicin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170602
[Lr] Data última revisão:
170602
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170423
[St] Status:MEDLINE
[do] DOI:10.1186/s12883-017-0836-z


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[PMID]:28366470
[Au] Autor:Saito H; Katagiri A; Okada S; Mikuzuki L; Kubo A; Suzuki T; Ohara K; Lee J; Gionhaku N; Iinuma T; Bereiter DA; Iwata K
[Ad] Endereço:Department of Complete Denture Prosthodontics, Nihon University School of Dentistry, 1-8-13 Kandasurugadai, Chiyoda-ku, Tokyo 101-8310, Japan; Department of Physiology, Nihon University School of Dentistry, 1-8-13 Kandasurugadai, Chiyoda-ku, Tokyo 101-8310, Japan. Electronic address: dehi14017@g.nih
[Ti] Título:Ascending projections of nociceptive neurons from trigeminal subnucleus caudalis: A population approach.
[So] Source:Exp Neurol;293:124-136, 2017 Jul.
[Is] ISSN:1090-2430
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Second-order neurons in trigeminal subnucleus caudalis (Vc) and upper cervical spinal cord (C1) are critical for craniofacial pain processing and project rostrally to terminate in: ventral posteromedial thalamic nucleus (VPM), medial thalamic nuclei (MTN) and parabrachial nuclei (PBN). The contribution of each region to trigeminal nociception was assessed by the number of phosphorylated extracellular signal-regulated kinase-immunoreactive (pERK-IR) neurons co-labeled with fluorogold (FG). The phenotype of pERK-IR neurons was further defined by the expression of neurokinin 1 receptor (NK1). The retrograde tracer FG was injected into VPM, MTN or PBN of the right hemisphere and after seven days, capsaicin was injected into the left upper lip in male rats. Nearly all pERK-IR neurons were found in superficial laminae of Vc-C1 ipsilateral to the capsaicin injection. Nearly all VPM and MTN FG-labeled neurons in Vc-C1 were found contralateral to the injection site, whereas FG-labeled neurons were found bilaterally after PBN injection. The percentage of FG-pERK-NK1-IR neurons was significantly greater (>10%) for PBN projection neurons than for VPM and MTN projection neurons (<3%). pERK-NK1-IR VPM projection neurons were found mainly in the middle-Vc, while pERK-NK1-immunoreactive MTN or PBN projection neurons were found in the middle-Vc and caudal Vc-C1. These results suggest that a significant percentage of capsaicin-responsive neurons in superficial laminae of Vc-C1 project directly to PBN, while neurons that project to VPM and MTN are subject to greater modulation by pERK-IR local interneurons. Furthermore, the rostrocaudal distribution differences of FG-pERK-NK1-IR neurons in Vc-C1 may reflect functional differences between these projection areas regarding craniofacial pain.
[Mh] Termos MeSH primário: Dor Facial/patologia
Nociceptores/patologia
Núcleos do Trigêmeo/patologia
[Mh] Termos MeSH secundário: Animais
Capsaicina/toxicidade
Modelos Animais de Doenças
MAP Quinases Reguladas por Sinal Extracelular/metabolismo
Dor Facial/induzido quimicamente
Masculino
Núcleo Mediodorsal do Tálamo/patologia
Vias Neurais/patologia
Vias Neurais/fisiologia
Nociceptores/metabolismo
Núcleos Parabraquiais/patologia
Ratos
Ratos Sprague-Dawley
Receptores da Neurocinina-1/metabolismo
Fármacos do Sistema Sensorial/toxicidade
Estatísticas não Paramétricas
Estilbamidinas/metabolismo
Núcleos Ventrais do Tálamo/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt); 0 (Receptors, Neurokinin-1); 0 (Sensory System Agents); 0 (Stilbamidines); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases); S07O44R1ZM (Capsaicin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE


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[PMID]:28335745
[Au] Autor:Enax-Krumova EK; Pohl S; Westermann A; Maier C
[Ad] Endereço:Department of Neurology, BG University Hospital Bergmannsheil GmbH, Ruhr University Bochum, Bürkle-de-la-Camp-Platz 1, D-44789, Bochum, Germany. elena.krumova@rub.de.
[Ti] Título:Ipsilateral and contralateral sensory changes in healthy subjects after experimentally induced concomitant sensitization and hypoesthesia.
[So] Source:BMC Neurol;17(1):60, 2017 Mar 23.
[Is] ISSN:1471-2377
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In unilateral neuropathic pain. e.g. after peripheral nerve injury, both positive and negative sensory signs occur often, accompanied by minor but equally directed contralateral sensory changes. To mimic this feature, we experimentally aimed to induce concomitant c-fibre sensitization and block in healthy subjects and analyzed the bilateral sensory changes by quantitative sensory testing (QST) using the protocol of the German Research Network on Neuropathic Pain. METHODS: Twenty eight healthy subjects were firstly randomized in 2 groups to receive either topical capsaicin (0.6%, 12 cm , application duration: 15 min.) or a lidocaine/prilocaine patch (25/25 mg, 10 cm , application duration: 60 min.) on the right volar forearm. Secondly, 7-14 days later in the same area either at first capsaicin (for 15 min.) and immediately afterwards local anesthetics (for 60 min.) was applied (Cap/LA), or in inversed order with the same application duration (LA/Cap). Before, after each application and 7-14 days later a QST was performed bilaterally. STATISTICS: Wilcoxon-test, ANOVA, p < 0.05. RESULTS: Single application of 0,6% capsaicin induced thermal hypoesthesia, cold hypoalgesia, heat hyperalgesia and tactile allodynia. Lidocaine/prilocaine alone induced thermal and tactile hypoesthesia as well as mechanical and cold hypoalgesia, and a heat hyperalgesia (to a smaller extent). Ipsilaterally both co-applications induced a combination of the above mentioned changes. Significant contralateral sensory changes occurred only after the co-application with concomitant sensitization and hypoesthesia and comprised increased cold (Cap/LA, LA/Cap) and mechanical detection as well as cold pain threshold (LA/Cap). CONCLUSION: The present experimental model using combined application of capsaicin and LA imitates partly the complex sensory changes observed in patients with unilateral neuropathic pain and might be used as an additional surrogate model. Only the concomitant use both agents in the same area induces both positive and negative sensory signs ipsilaterally as well as parallel contralateral sensory changes (to a lesser extent). TRIAL REGISTRATION: ClinicalTrials.gov Identifier NCT01540877 , registered on 23 February 2012.
[Mh] Termos MeSH primário: Anestésicos Locais/farmacologia
Capsaicina/farmacologia
Lidocaína/farmacologia
Neuralgia/fisiopatologia
Prilocaína/farmacologia
Fármacos do Sistema Sensorial/farmacologia
Distúrbios Somatossensoriais/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Anestésicos Locais/administração & dosagem
Capsaicina/administração & dosagem
Feminino
Voluntários Saudáveis
Seres Humanos
Hipestesia/induzido quimicamente
Hipestesia/fisiopatologia
Lidocaína/administração & dosagem
Masculino
Meia-Idade
Modelos Neurológicos
Prilocaína/administração & dosagem
Fármacos do Sistema Sensorial/administração & dosagem
Distúrbios Somatossensoriais/induzido quimicamente
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anesthetics, Local); 0 (Sensory System Agents); 046O35D44R (Prilocaine); 98PI200987 (Lidocaine); S07O44R1ZM (Capsaicin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170510
[Lr] Data última revisão:
170510
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE
[do] DOI:10.1186/s12883-017-0839-9


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[PMID]:28112976
[Au] Autor:Shiri M; Komaki A; Oryan S; Taheri M; Komaki H; Etaee F
[Ad] Endereço:a Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
[Ti] Título:Effects of cannabinoid and vanilloid receptor agonists and their interaction on learning and memory in rats.
[So] Source:Can J Physiol Pharmacol;95(4):382-387, 2017 Apr.
[Is] ISSN:1205-7541
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:Despite previous findings on the effects of cannabinoid and vanilloid systems on learning and memory, the effects of the combined stimulation of these 2 systems on learning and memory have not been studied. Therefore, in this study, we tested the interactive effects of cannabinoid and vanilloid systems on learning and memory in rats by using passive avoidance learning (PAL) tests. Forty male Wistar rats were divided into the following 4 groups: (1) control (DMSO+saline), (2) WIN55,212-2, (3) capsaicin, and (4) WIN55,212-2 + capsaicin. On test day, capsaicin, a vanilloid receptor type 1 (TRPV1) agonist, or WIN55,212-2, a cannabinoid receptor (CB /CB ) agonist, or both substances were injected intraperitoneally. Compared to the control group, the group treated with capsaicin (TRPV1 agonist) had better scores in the PAL acquisition and retention test, whereas treatment with WIN55,212-2 (CB /CB agonist) decreased the test scores. Capsaicin partly reduced the effects of WIN55,212-2 on PAL and memory. We conclude that the acute administration of a TRPV1 agonist improves the rats' cognitive performance in PAL tasks and that a vanilloid-related mechanism may underlie the agonistic effect of WIN55,212-2 on learning and memory.
[Mh] Termos MeSH primário: Aprendizagem da Esquiva/efeitos dos fármacos
Benzoxazinas/farmacologia
Agonistas de Receptores de Canabinoides/farmacologia
Capsaicina/farmacologia
Cognição/efeitos dos fármacos
Memória/efeitos dos fármacos
Morfolinas/farmacologia
Naftalenos/farmacologia
Canais de Cátion TRPV/agonistas
[Mh] Termos MeSH secundário: Animais
Benzoxazinas/administração & dosagem
Bloqueadores dos Canais de Cálcio/farmacologia
Canabinoides
Capsaicina/administração & dosagem
Injeções Intraperitoneais
Masculino
Morfolinas/administração & dosagem
Naftalenos/administração & dosagem
Ratos
Ratos Wistar
Fármacos do Sistema Sensorial/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzoxazines); 0 (Calcium Channel Blockers); 0 (Cannabinoid Receptor Agonists); 0 (Cannabinoids); 0 (Morpholines); 0 (Naphthalenes); 0 (Sensory System Agents); 0 (TRPV Cation Channels); 5H31GI9502 (Win 55212-2); S07O44R1ZM (Capsaicin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170124
[St] Status:MEDLINE
[do] DOI:10.1139/cjpp-2016-0274


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[PMID]:28072808
[Au] Autor:Levesque A; Riant T; Labat JJ; Ploteau S
[Ad] Endereço:Federative Pelvic Pain Center, Nantes, France.
[Ti] Título:Use of High-Concentration Capsaicin Patch for the Treatment of Pelvic Pain: Observational Study of 60 Inpatients.
[So] Source:Pain Physician;20(1):E161-E167, 2017 Jan-Feb.
[Is] ISSN:2150-1149
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Chronic pelvic, perineal and gluteal neuralgia is often experienced in a similar way to neuropathic pain, in the territories of four nerves: ilio-inguinal, pudendal, inferior cluneal and posterior gluteal nerves. These pains are often refractory to medical treatment based on the use of systemic molecules with disabling adverse effects and surgical procedure may be necessary. OBJECTIVE: The objective of this study was to evaluate the efficacy and safety of treatment with a high-concentration capsaicin patch in these indications. STUDY DESIGN: This study was prospective, nonrandomized, and observational. SETTING: Federative Center of Pelvi-Perineology in the University Hospital of Nantes, France. METHODS: Sixty patients with pelvic neuralgia were treated with high-concentration capsaicin patch. The primary endpoint was Patient Global Impression of Change (PGIC) and secondary endpoints included pain intensity on a Numerical Rating Scale (NRS), maximum sitting duration at the end of the day, Medication Consumption Score (MQS), and patient global improvement (from -100% to + 100%). RESULTS: Twenty four percent of the 60 patients included in the study declared that they felt "very much improved" or "much improved" (PGIC = 1 or 2) and these patients reported an average 58% improvement and a 3.4-point reduction on the NRS. Among the "good responder" patients, patients with coccygodynia appear to obtain the bestresults, as 37% of these patients declared that they were much improved with an average 63% improvement No serious adverse effects were observed and treatment was well tolerated. LIMITATION: This study is limited by its relatively small sample size and non-randomized study. CONCLUSION: These results suggest the value of high-concentration capsaicin 8% patch in the treatment strategy for patients with chronic pelvic, perineal and gluteal neuralgia. This treatment would be particularly indicated in the management of coccygodynia.Key words: Pelvic pain, neuropathic pain, pudendal nerve, ilio-inguinal nerve, inferior cluneal nerve, posterior gluteal nerve, capsaicin, capsaicin patch, coccygodynia.
[Mh] Termos MeSH primário: Capsaicina
Dor Pélvica/tratamento farmacológico
Fármacos do Sistema Sensorial
[Mh] Termos MeSH secundário: Capsaicina/administração & dosagem
Capsaicina/uso terapêutico
Seres Humanos
Pacientes Internados
Neuralgia/tratamento farmacológico
Medição da Dor
Estudos Prospectivos
Fármacos do Sistema Sensorial/administração & dosagem
Fármacos do Sistema Sensorial/uso terapêutico
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Sensory System Agents); S07O44R1ZM (Capsaicin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170721
[Lr] Data última revisão:
170721
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170111
[St] Status:MEDLINE


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[PMID]:28007005
[Au] Autor:Jørgensen MR; Pedersen AM
[Ad] Endereço:a Department of Odontology, Section for Oral Medicine, Clinical Oral Physiology, Oral Anatomy and Pathology, Faculty of Health and Medical Sciences , University of Copenhagen , Copenhagen N , Denmark.
[Ti] Título:Analgesic effect of topical oral capsaicin gel in burning mouth syndrome.
[So] Source:Acta Odontol Scand;75(2):130-136, 2017 Mar.
[Is] ISSN:1502-3850
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To investigate the effectiveness of repeated topical application of oral capsaicin gel in two different concentrations for relief of burning/stinging sensations in patients with burning mouth syndrome (BMS). MATERIAL AND METHODS: This randomized double-blind cross-over study included 22 female patients with BMS. The patients were randomized for topical application of either 0.01% or 0.025% oral capsaicin gel on the dorsal part of tongue three times daily for 14 days, followed by 14 days wash-out period, and finally treatment with the other concentration of oral gel three times daily for 14 days. A visual analogue scale (VAS) was used to assess the severity of pain five times during the intervention period. RESULTS: 18 patients completed the intervention. Their VAS score at baseline was 5.5 ± 0.6 cm (mean ± SD). Treatment with the two concentrations of capsaicin gels significantly improved the burning/stinging symptoms assessed on VAS compared with baseline (p = 0.002). There was no statistically significant difference between the two concentrations of the gels on relieving symptoms. Four patients dropped out during the intervention period due to gastrointestinal side-effects. CONCLUSIONS: Topical capsaicin might be an alternative for the short-term treatment of BMS. However, further studies are needed to investigate especially the gastro-intestinal side-effects which may limit its long-term use.
[Mh] Termos MeSH primário: Analgésicos/administração & dosagem
Síndrome da Ardência Bucal/tratamento farmacológico
Capsaicina/administração & dosagem
Fármacos do Sistema Sensorial/administração & dosagem
[Mh] Termos MeSH secundário: Administração Tópica
Adulto
Idoso
Síndrome da Ardência Bucal/prevenção & controle
Estudos Cross-Over
Método Duplo-Cego
Feminino
Seres Humanos
Meia-Idade
Dor/tratamento farmacológico
Medição da Dor
Resultado do Tratamento
Escala Visual Analógica
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Analgesics); 0 (Sensory System Agents); S07O44R1ZM (Capsaicin)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:161224
[St] Status:MEDLINE
[do] DOI:10.1080/00016357.2016.1269191



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