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[PMID]:28678953
[Au] Autor:Alexandrino LD; Alencar CM; Silveira ADSD; Alves EB; Silva CM
[Ad] Endereço:Universidade Federal do Pará, Belém, PA, Brasil.
[Ti] Título:Randomized clinical trial of the effect of NovaMin and CPP-ACPF in combination with dental bleaching.
[So] Source:J Appl Oral Sci;25(3):335-340, 2017 May-Jun.
[Is] ISSN:1678-7765
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Objective: This randomized, controlled, double-blind clinical study evaluated the effect of calcium sodium phosphosilicate (NovaMin) and casein phosphopeptide-amorphous calcium phosphate with fluoride (CPP-ACPF) on the prevention of post-operative sensitivity and on the effects of clinical bleaching treatment. Material and Methods: Sixty volunteers were selected according to inclusion and exclusion criteria and were randomly assigned into three groups (n=20): CG (control group) patients, who were treated with 35% hydrogen peroxide; NOVAG (NovaMin group) patients, who were treated with 35% hydrogen peroxide followed by the application of NovaMin; and CPPG (CPP group) patients, who were treated with 35% hydrogen peroxide followed by the application of CPP-ACPF. Both bioactive agents were applied for five minutes. An evaporative stimulus associated with a modified visual scale was used to analyze sensitivity 24 hours after each bleaching session. The color evaluation was performed on the maxillary central incisors using a spectrophotometer. Associations between the intervention group, bleaching session, and reported sensitivity were tested using Chi-square partitioning. Results: Color change values (ΔE) were analyzed using analysis of variance (ANOVA). The significance level used for both tests was 5%. In the intragroup assessment, the Friedman test showed that only the CPP-ACPF group showed no statistically significant difference (p<0.05) between baseline and first bleaching session. In the intergroup assessment, the Kruskal-Wallis test showed that the CPPG had less postoperative sensitivity after the first session, when compared to the other groups (p<0.05). Color change analysis (ΔE) showed a significant difference between the means obtained in the different bleaching sessions in all groups (p<0.05). Conclusions: This study showed that the combination of CPP-ACPF with 35% hydrogen peroxide significantly reduced post-operative sensitivity in the first session, compared with the other evaluated treatments. The association of CPP-ACPF and NovaMin did not affect the color change induced by tooth bleaching.
[Mh] Termos MeSH primário: Caseínas/uso terapêutico
Dessensibilizantes Dentinários/uso terapêutico
Sensibilidade da Dentina/prevenção & controle
Fluoretos/uso terapêutico
Vidro/química
Clareamento Dental/efeitos adversos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Análise de Variância
Cor
Esmalte Dentário/efeitos dos fármacos
Método Duplo-Cego
Quimioterapia Combinada
Feminino
Seres Humanos
Peróxido de Hidrogênio/efeitos adversos
Masculino
Período Pós-Operatório
Reprodutibilidade dos Testes
Espectrofotometria
Fatores de Tempo
Clareadores Dentários/efeitos adversos
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Caseins); 0 (Dentin Desensitizing Agents); 0 (NovaMin); 0 (Tooth Bleaching Agents); 0 (casein phosphopeptide-amorphous calcium phosphate nanocomplex); BBX060AN9V (Hydrogen Peroxide); Q80VPU408O (Fluorides)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170706
[St] Status:MEDLINE


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[PMID]:28293873
[Au] Autor:Cunha SR; Garófalo SA; Scaramucci T; Zezell DM; Aranha ACC
[Ad] Endereço:Department of Restorative Dentistry, School of Dentistry, University of São Paulo, Av. Professor Lineu Prestes 2227, São Paulo, SP, Brazil.
[Ti] Título:The association between Nd:YAG laser and desensitizing dentifrices for the treatment of dentin hypersensitivity.
[So] Source:Lasers Med Sci;32(4):873-880, 2017 May.
[Is] ISSN:1435-604X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study aims to evaluate the association between Nd:YAG laser (with and without a photoabsorber) and two desensitizing dentifrices containing 15% NovaMin or 8% arginine, as potential treatments for dentin hypersensitivity (DH). DH was simulated by EDTA application for 2 min. Specimens were then analyzed with an environmental scanning electron microscope (ESEM) to ensure open dentin tubules (ODT), counted by using ImageJ software. Specimens were randomized into eight groups (n = 10): Laser (L), Laser+Photoabsorber (LP), Arginine (A), Arginine+Laser (AL), Arginine+Laser+Photoabsorber (ALP), NovaMin (N), NovaMin+Laser (NL), and NovaMin+Laser+Photoabsorber (NLP). Laser irradiation was performed with 1 W, 100 mJ, 10 Hz, ≅85 J/cm ; 4 irradiations of 10 s each, with 10 s intervals between them. After treatment, specimens were again analyzed by ESEM and submitted to erosive/abrasive cycling for 5 days. A final ESEM analysis was performed. Data were analyzed with two-way repeated measure ANOVA and Tukey tests (α = 0.05). After treatment, groups N, NL, and NLP presented the lower number of ODT, but they did not different from LP, ALP, and AL. Group A presented the highest number of ODT and it did not differ from group L. Groups L, AL, ALP, and LP presented intermediate results, without differing from each other. After cycling, group A presented the highest number of ODT and did not differ significantly from the other groups, except NLP. None of the associations tested presented better tubule occlusion than NovaMin by itself. Arginine was the only treatment that presented improved tubule occlusion when associated with Nd:YAG laser.
[Mh] Termos MeSH primário: Dentifrícios/efeitos da radiação
Dessensibilizantes Dentinários/farmacologia
Sensibilidade da Dentina/radioterapia
Lasers de Estado Sólido/uso terapêutico
[Mh] Termos MeSH secundário: Dentina/efeitos da radiação
Dentina/ultraestrutura
Vidro
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dentifrices); 0 (Dentin Desensitizing Agents); 0 (NovaMin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE
[do] DOI:10.1007/s10103-017-2187-9


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[PMID]:28198974
[Au] Autor:Ishihata H; Kanehira M; Finger WJ; Takahashi H; Tomita M; Sasaki K
[Ad] Endereço:Tohoku University, Graduate School of Dentistry, Division of Periodontology and Endodontology, Department of Oral Biology, Sendai, Japan.
[Ti] Título:Effect of two desensitizing agents on dentin permeability in vitro.
[So] Source:J Appl Oral Sci;25(1):34-41, 2017 Jan-Feb.
[Is] ISSN:1678-7765
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Objective: The aim of this in vitro study was to investigate the effect of two desensitizing agents and water on hydraulic conductance in human dentin. Material and Methods: GLUMA Desensitizer PowerGel (GLU) contains glutaraldehyde (GA) and 2-hydroxyethyl methacrylate (HEMA), and Teethmate Desensitizer (TD) is a powder comprising tetracalcium phosphate (TTCP) and dicalcium phosphate anhydrous (DCPA) that is mixed with water. Deionized water was used as a negative control (CTR). Thirty discs with a thickness of 1.2 mm were cut from the coronal dentin of the third molars and cleaned with 0.5 M EDTA (pH 7.4). After being mounted in a split-chamber device, the discs were pressurized with water at 1 kPa and 3 kPa in order to measure flow rates with a highly sensitive micro-flow sensor and to calculate hydraulic conductance as a baseline value (BL). Following the application of GLU, TD, and CTR (n=10), hydraulic conductance was remeasured with intermittent storage in water after 15 min, 1 d, 1 w, and 1 m. Reduction in permeability (PR%) was calculated from hydraulic conductance. Data were statistically analyzed using nonparametric methods (α<0.05). Representative discs were inspected by SEM. Results: PR% for GLU and TD were 30-50% 15 min and 1 m after their application. Post hoc tests indicated that PR% of CTR was significantly greater than those of GLU and TD at all time points tested. The PR% of GLU and TD were not significantly different. SEM examinations showed noncollapsed collagen meshes at the tubular entrances after GLU, and crystalline precipitates occluding the tubular orifices after TD, whereas CTR specimens showed typical patterns of etched dentin. Conclusions: The present study on hydraulic conductance in dentin discs treated with two chemically different desensitizing agents and water as a control demonstrated that both products may be characterized as effective.
[Mh] Termos MeSH primário: Fosfatos de Cálcio/química
Dessensibilizantes Dentinários/química
Permeabilidade da Dentina/efeitos dos fármacos
Dentina/efeitos dos fármacos
Glutaral/química
Metacrilatos/química
[Mh] Termos MeSH secundário: Ácido Edético/química
Seres Humanos
Teste de Materiais
Microscopia Eletrônica de Varredura
Distribuição Aleatória
Estatísticas não Paramétricas
Propriedades de Superfície
Fatores de Tempo
Água/química
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Calcium Phosphates); 0 (Dentin Desensitizing Agents); 0 (Methacrylates); 0 (gluma desensitizer); 0 (tetracalcium phosphate); 059QF0KO0R (Water); 9G34HU7RV0 (Edetic Acid); L11K75P92J (calcium phosphate, dibasic, anhydrous); T3C89M417N (Glutaral)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170216
[St] Status:MEDLINE


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[PMID]:28090810
[Au] Autor:Matsuyoshi S; Murayama R; Akiba S; Yabuki C; Takamizawa T; Kurokawa H; Miyazaki M
[Ad] Endereço:a Department of Operative Dentistry , Nihon University School of Dentistry , Chiyoda-ku , Tokyo , Japan.
[Ti] Título:Enamel remineralization effect of a dentifrice containing calcium sodium phosphosilicate: an optical coherence tomography observation.
[So] Source:Acta Odontol Scand;75(3):191-197, 2017 Apr.
[Is] ISSN:1502-3850
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The purpose of this study was to examine the effects of a dentifrice containing 5% calcium sodium phosphosilicate (CSP) on the remineralization of the enamel using optical coherence tomography (OCT). MATERIALS AND METHODS: Bovine incisors were sliced and shaped in a rectangular form. One group of five specimens was treated with undersaturated 0.1 M lactic acid buffer solution (pH 4.75) for 10 min and then placed in artificial saliva (pH 7.0) (De group). Other specimens were stored in solutions of toothpaste containing CSP for 10 min, followed by 10-min immersion in the lactic acid buffer solution twice a day before storage in artificial saliva (CSP group). An additional group was stored in only artificial saliva (control group). OCT imaging on the selected location of the enamel surface was performed. The peak intensity and width at 1/e were recorded in each of the six areas on the sample and averaged, and the sample size of each group was six. The integrated value in units (dB × µm) was calculated in the area of peak intensity. The data for each group was subjected to one-way repeated-measures ANOVA and Tukey HSD tests (α = 0.05). RESULTS: The changes in integrated values of each group were different. A slight but significant increase in the integrated value was observed in the control group, whereas a slight but significant decrease in the value was observed the De group. Integrated values increased in the CSP group. CONCLUSIONS: Remineralization occurred upon immersion in the toothpaste containing CSP.
[Mh] Termos MeSH primário: Fosfatos de Cálcio/uso terapêutico
Esmalte Dentário/efeitos dos fármacos
Dentifrícios/uso terapêutico
Dessensibilizantes Dentinários/uso terapêutico
Tomografia de Coerência Óptica/métodos
Desmineralização do Dente/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Bovinos
Dentifrícios/farmacologia
Saliva Artificial
Fluoreto de Sódio
Remineralização Dentária/métodos
Cremes Dentais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Calcium Phosphates); 0 (Dentifrices); 0 (Dentin Desensitizing Agents); 0 (Saliva, Artificial); 0 (Toothpastes); 8ZYQ1474W7 (Sodium Fluoride)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170616
[Lr] Data última revisão:
170616
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170117
[St] Status:MEDLINE
[do] DOI:10.1080/00016357.2016.1277588


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[PMID]:28076496
[Au] Autor:Madruga MM; Silva AF; Rosa WL; Piva E; Lund RG
[Ad] Endereço:Universidade Federal de Pelotas - UFPEL, School of Dentistry, Program of Post-Graduate in Dentistry, Pelotas, RS, Brazil.
[Ti] Título:Evaluation of dentin hypersensitivity treatment with glass ionomer cements: A randomized clinical trial.
[So] Source:Braz Oral Res;31:e3, 2017 Jan 05.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:A randomized, double-blind, split-mouth clinical trial was performed compared the desensitizing efficacy of the resin-modified glass ionomer cement (GIC) ClinproTM XT (3M ESPE, Minnesota, USA) and the conventional GIC Vidrion R (SS White, Gloucester, UK) in a 6-month follow-up. Subjects were required to have at least two teeth with dentin hypersensitivity. Teeth were divided at random into 2 groups, one group received Clinpro XT and the other conventional GIC Vidrion R. Treatments were assessed by tactile and air blast tests using Visual Analogue Scale (VAS) at baseline, after 20 minutes, and at 7, 15, 21, 30, 90 and 180 days post-treatment. Twenty subjects (152 teeth) were included. Both tests (tactile and air blast) showed a significant reduction of dentin hypersensitivity immediately after the application of Vidrion R and Clinpro XT (20 min). VAS scores obtained along the 6-month follow-up were statistically lower when compared to initial rates (p < 0.05). Both GIC were able to reduce dentin hypersensitivity up to 6-month post-treatment period without statistically significant differences among them (p > 0.05). Both cements provided satisfactory results in long-term dental sensitivity reduction.
[Mh] Termos MeSH primário: Resinas Compostas/uso terapêutico
Dessensibilizantes Dentinários/uso terapêutico
Sensibilidade da Dentina/terapia
Cimentos de Ionômeros de Vidro/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Dentina/efeitos dos fármacos
Método Duplo-Cego
Feminino
Seres Humanos
Masculino
Meia-Idade
Medição da Dor
Reprodutibilidade dos Testes
Estatísticas não Paramétricas
Fatores de Tempo
Resultado do Tratamento
Escala Visual Analógica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Composite Resins); 0 (Dentin Desensitizing Agents); 0 (Glass Ionomer Cements); 0 (Vidrion-R)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170308
[Lr] Data última revisão:
170308
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170112
[St] Status:MEDLINE


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[PMID]:27734160
[Au] Autor:Femiano F; Femiano R; Lanza A; Lanza M; Perillo L
[Ad] Endereço:Multidisciplinary Department of Medical-Surgical and Dental Specialties, Second University of Naples, Via De Crecchio 8, 83100, Naples, Italy. femiano@libero.it.
[Ti] Título:Effectiveness on oral pain of 808-nm diode laser used prior to composite restoration for symptomatic non-carious cervical lesions unresponsive to desensitizing agents.
[So] Source:Lasers Med Sci;32(1):67-71, 2017 Jan.
[Is] ISSN:1435-604X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study compares sensitivity reduction after dental restoration with and without prior diode laser (DL) irradiation for cervical dentine hypersensitivity (CDH) from non-carious cervical lesions (NCCLs) unresponsive to desensitizing agents. Eighty-eight teeth of 28 subjects (21 females; age 23-64 years), with CDH from NCCL were included in this study. NCCLs of each oral quadrant were randomized in two groups (study group (SG)) to estimate the sensitivity reduction after dental restoration (SG-1) compared with the DL irradiation used prior to restoration placement (SG-2). The subjects were asked to rate the sensitivity experienced during air stimulation using a visual analog scale before (baseline), immediately after, and at 6 and 12 months from restoration. The outcomes showed a significant reduction of discomfort compared to baseline for NCCLs of SG-2 with the decrease of 78.5, 78.9, and 78.1 % immediately and at 6 and 12 months after restoration, respectively; in comparison with the decrease of 70.1, 67, and 65.3 % for NCCLs of SG-1 immediately and at 6 and 12 months after restoration, respectively; and compared to baseline. The DL irradiation prior to dental restoration can further improve the painful symptomatology of CDH from NCCL unresponsive to desensitizing agents.
[Mh] Termos MeSH primário: Dessensibilizantes Dentinários/uso terapêutico
Sensibilidade da Dentina/tratamento farmacológico
Sensibilidade da Dentina/cirurgia
Lasers Semicondutores/uso terapêutico
Dor/cirurgia
Colo do Dente/patologia
Colo do Dente/cirurgia
[Mh] Termos MeSH secundário: Adulto
Sensibilidade da Dentina/complicações
Feminino
Seres Humanos
Masculino
Meia-Idade
Dor/complicações
Medição da Dor
Colo do Dente/efeitos da radiação
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dentin Desensitizing Agents)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161014
[St] Status:MEDLINE
[do] DOI:10.1007/s10103-016-2087-4


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[PMID]:27737364
[Au] Autor:Rosa RR; Calazans FK; Nogueira RD; Lancellotti AC; Gonçalves LS; Geraldo-Martins VR
[Ad] Endereço:Universidade de Uberaba, School of Dentistry, Uberaba, MG, Brazil.
[Ti] Título:Effects of different desensitizing treatments on root dentin permeability.
[So] Source:Braz Oral Res;30(1):e111, 2016 Oct 10.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to evaluate the effects of diode laser and a desensitizing dentifrice on dentin permeability. Fifty-two root dentin fragments were obtained (5 × 5mm) and treated with 24% EDTA gel. The samples were divided into 4 groups (n = 13): G1, control (no treatment); G2, diode laser (λ = 908 nm, 1.5 W, continuous mode, 20s); G3, application of abrasive dentifrice for 1 minute (Elmex Sensitive Professional (International Gaba); and G4, application of abrasive dentifrice for 1 minute followed by irradiation with diode laser. Ten samples per group were immersed in 2% methylene blue solution for 4h. The specimens were washed, longitudinally sectioned, observed under optical microscopy, photographed and assessed based on the degree of dye leakage. The remaining samples were observed under scanning electron microscopy (SEM). The leakage data were subjected to ANOVA test, followed by Tukey's t-test (α = 5%). Groups 2, 3 and 4 showed less dye penetration than the control group (p < 0.05), but were similar among each other. SEM images showed that dentinal tubules were open in G1, and fused and occluded in G2. Group 3 showed dentinal tubules that were occluded by the metal ions from the toothpaste. G4 presented similar characteristics to G3, and the presence of fused dentin. The diode laser and the dentifrice were effective in reducing dentinal permeability, and the combination of the two treatments did not show better results than either one used alone.
[Mh] Termos MeSH primário: Dentifrícios/química
Dessensibilizantes Dentinários/química
Permeabilidade da Dentina/efeitos dos fármacos
Sensibilidade da Dentina/tratamento farmacológico
Dentina/efeitos dos fármacos
Raiz Dentária/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Bovinos
Dentina/efeitos da radiação
Permeabilidade da Dentina/efeitos da radiação
Terapia a Laser/métodos
Lasers Semicondutores/uso terapêutico
Microscopia Eletrônica de Varredura
Distribuição Aleatória
Reprodutibilidade dos Testes
Propriedades de Superfície/efeitos dos fármacos
Propriedades de Superfície/efeitos da radiação
Fatores de Tempo
Raiz Dentária/efeitos da radiação
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dentifrices); 0 (Dentin Desensitizing Agents)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:161014
[St] Status:MEDLINE


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[PMID]:27505989
[Au] Autor:Dávila-Sánchez A; Montenegro AF; Alfonso AG; Farago PV; Loguercio AD; Reis A
[Ti] Título:Potential of desensitizing toothpastes to reduce the hydrogen peroxide diffusion in teeth with cervical lesions.
[So] Source:Am J Dent;29(3):139-44, 2016 Jun.
[Is] ISSN:0894-8275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To evaluate the occlusive potential of four toothpastes by atomic force microscopy (AFM) before and after bleaching and quantify the hydrogen peroxide (HP) diffusion into the pulp chamber after application of desensitizing toothpastes in teeth with cervical lesions. METHODS: In 52 human extracted premolars, 2-mm deep artificial cervical lesions (ACL) were prepared and rinsed with EDTA for 10 seconds. Then teeth were adapted in a brushing machine and brushed with one of the following toothpastes [Regular toothpaste with no occlusive compounds Colgate Cavity Protection (CP), Oral-B Pro Health (OB), Colgate ProRelief (PR) and Sensodyne Rapid Relief (RR)] under constant loading (250 g; 4.5 cycles/seconds; 3 minutes). In 13 teeth (control group), no artificial cervical lesion was prepared. After that, the teeth were bleached with 35% HP with three 15-minute applications. The HP diffusion was measured spectrophotometrically as a stable red product based on HP reaction with 4-aminoanthipyrine and phenol in presence of peroxidase, at a wavelength of 510 nm and the dentin surfaces of ACL were evaluated before and after bleaching by AFM. Data was statistically analyzed by one-way ANOVA and Tukey's test (alpha = 0.05). RESULTS: In the AFM images, some modifications of the dentin surface were observed after application of OB and RR. However, only for RR the formation of a surface deposit was produced, which occluded the majority of the dentin tubules. Also, only for RR, this deposit was not modified/removed by bleaching. Despite this, all groups with ACL showed higher HP penetration than sound teeth, regardless of the toothpaste used (P < 0.001).
[Mh] Termos MeSH primário: Dessensibilizantes Dentinários/uso terapêutico
Sensibilidade da Dentina/prevenção & controle
Peróxido de Hidrogênio/química
Colo do Dente/patologia
Cremes Dentais
[Mh] Termos MeSH secundário: Difusão
Seres Humanos
Microscopia de Força Atômica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dentin Desensitizing Agents); 0 (Toothpastes); BBX060AN9V (Hydrogen Peroxide)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160810
[Lr] Data última revisão:
160810
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:160811
[St] Status:MEDLINE


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[PMID]:27359118
[Au] Autor:Zhou J; Chiba A; Scheffel DL; Hebling J; Agee K; Niu LN; Tay FR; Pashley DH
[Ad] Endereço:Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China.
[Ti] Título:Effects of a Dicalcium and Tetracalcium Phosphate-Based Desensitizer on In Vitro Dentin Permeability.
[So] Source:PLoS One;11(6):e0158400, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The present study evaluated the effectiveness of a dicalcium and tetracalcium phosphate-based desensitizer in reducing dentin permeability in vitro. Dentin fluid flow was measured before and after treatment of dentin with patent dentinal tubules using 1 or 3 applications of the dicalcium and tetracalcium phosphate containing agent TeethmateTM (TM) and comparing the results with two sodium fluoride varnishes VellaTM (VLA) and VanishTM (VAN), after storage in artificial saliva for 24 h, 48 h and 7 days. Significant differences were observed among the 4 methods employed for reducing dentin permeability (p < 0.001) and the 3 post-treatment times (p < 0.001). VLA and VAN never achieved 50% permeability reductions consistently in any of the 3 time periods. Only the calcium phosphate-based desensitizer applied for 3 times consistently reduced dentin permeability by 50% after 24 h. When applied once, the permeability reduction of TM increased progressively over the 3 time periods. After 7 days, only one and three applications of the calcium phosphate-based desensitizer consistently reduced dentin permeability by more than 50%. Permeability reductions corresponded well with scanning electron microscopy examination of dentinal tubule orifice occlusion in dentin specimens treated with the agents. Overall, the dicalcium and tetracalcium phosphate-based desensitizer is effective in reducing dentin permeability via a tubule occlusion mechanism. The ability of the agent to reduce dentin permeability renders it to be potentially useful as a clinical dentin desensitizing agent, which has to be confirmed in future clinical studies. By contrast, the two sodium fluoride varnishes are not effective in dentin permeability reduction and should be considered as topical fluoride delivering agents rather than tubular orifice-blocking agents.
[Mh] Termos MeSH primário: Fosfatos de Cálcio/farmacologia
Dessensibilizantes Dentinários/farmacologia
Permeabilidade da Dentina/efeitos dos fármacos
[Mh] Termos MeSH secundário: Dentina/efeitos dos fármacos
Dentina/metabolismo
Dentina/ultraestrutura
Sensibilidade da Dentina/tratamento farmacológico
Sensibilidade da Dentina/metabolismo
Seres Humanos
Técnicas In Vitro
Teste de Materiais
Microscopia Eletrônica de Varredura
Dente Serotino
Saliva Artificial
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Calcium Phosphates); 0 (Dentin Desensitizing Agents); 0 (Saliva, Artificial); 0 (tetracalcium phosphate); L11K75P92J (calcium phosphate, dibasic, anhydrous)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170718
[Lr] Data última revisão:
170718
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160701
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0158400


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[PMID]:27337923
[Au] Autor:Yang S; Ying K; Wang F; Chen K; Zhou L; Yang Q
[Ti] Título:[Desensitizing effect of stannous fluoride-containing toothpaste for patients with dentine hypersensitivity: a Meta-analysis].
[So] Source:Hua Xi Kou Qiang Yi Xue Za Zhi;34(2):150-5, 2016 Apr.
[Is] ISSN:1000-1182
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: This study aims to assess the effects of desensitizing toothpaste containing stannous fluoride on dentine hypersensitivity by performing Meta-analysis of randomized controlled trials (RCT) involving the treatment of dentine hypersensitivity with stannous fluoride-containing toothpaste. METHODS: The study was developed based on the Cochrane handbook for systematic reviews of interventions (Version 5.1.0) and included the following: search strategy, selection criteria, data extraction, and risk of bias assessment. We searched electronic databases such as CNKI, CBM, PubMed, Embase, and Cochrane Library up to January 2015. RCT of treating dentine hypersensitivity with stannous fluoride-containing toothpaste were included. Data extraction and domain-based risk of bias assessment were independently performed by two reviewers. Meta-analysis was performed with RevMan 5.3 software. RESULTS: Six RCT with 494 patients (247 in the experimental group and 247 in the control group) were included. The results of Meta-analysis showed that the desensitizing effect of stannous fluoride-containing toothpaste was significantly better than that of control in tactile sensitivity test (SMD=1.41, 95% confidence interval 0.74-2.09, P<0.00001) and air blast test (SMD = -1.16, 95% confidence interval -1.84--0.48, P<0.000 01). CONCLUSION: Current evidence shows that stannous fluoride-containing toothpaste is effective in treating dentine hypersensitivity in clinic. However, due to limited sample size and lower quality of the included studies, more high quality and large-sample RCT are needed to further verify the evidence.
[Mh] Termos MeSH primário: Dessensibilizantes Dentinários/uso terapêutico
Sensibilidade da Dentina/tratamento farmacológico
Fluoretos de Estanho/uso terapêutico
Cremes Dentais/uso terapêutico
[Mh] Termos MeSH secundário: Seres Humanos
Ensaios Clínicos Controlados Aleatórios como Assunto
Fluoreto de Sódio
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Nm] Nome de substância:
0 (Dentin Desensitizing Agents); 0 (Tin Fluorides); 0 (Toothpastes); 8ZYQ1474W7 (Sodium Fluoride)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170111
[Lr] Data última revisão:
170111
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:160625
[St] Status:MEDLINE



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