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  1 / 2114 MEDLINE  
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[PMID]:29240785
[Au] Autor:Lu W; Hwang JK; Zeng F; Leal WS
[Ad] Endereço:Department of Molecular and Cellular Biology, University of California Davis, Davis, CA, United States of America.
[Ti] Título:DEET as a feeding deterrent.
[So] Source:PLoS One;12(12):e0189243, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The insect repellent N,N-diethyl-3-methylbenzamide (DEET), is a multimodal compound that acts as a spatial repellent as well as an irritant (contact repellent), thus being perceived by the insect's olfactory and gustatory systems as an odorant and a tastant, respectively. Soon after DEET was developed, almost 6 decades ago, it was reported that it reduced mosquito feeding on blood mixed with this repellent. It is now known that the mosquito proboscis senses contact repellents with the tips (labella) of the labium, which remain in direct contact with the outer layers of the skin, while the stylets, including the feeding deterrent sensor (labrum), penetrate the skin. We designed a behavioral assay that allowed us to measure feeding deterrence without complications from contact or spatial repellency. Using the southern house mosquito, Culex quinquefasciatus, we demonstrate here that when DEET was mixed with blood and covered by Parafilm® layers, the mean number of landings and duration of contacts with surfaces covering blood mixed with DEET or blood plus solvent (dimethyl sulfoxide) did not differ significantly thus implying that DEET did not leak to the outer surface. The feeding times, however, were significantly different. When blood was mixed either with 0.1 or 1% DEET, female southern house mosquitoes spent significantly (P<0.0001) less time feeding than the time spent feeding on blood mixed only with the solvent. By contrast, significant differences in the mean times of feeding on blood containing 1% picaridin and blood plus solvent were significant at 5%, but not at 1% level. Like DEET, the contact repellent and insecticide, permethrin, caused a significant (P<0.0001) reduction in feeding time. We, therefore, concluded, that in this context, DEET, permethrin, and, to a lesser extent, picaridin, act as feeding deterrents.
[Mh] Termos MeSH primário: Culex/efeitos dos fármacos
DEET/farmacologia
Comportamento Alimentar/efeitos dos fármacos
Repelentes de Insetos/farmacologia
[Mh] Termos MeSH secundário: Animais
Culex/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insect Repellents); 134-62-3 (DEET)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189243


  2 / 2114 MEDLINE  
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[PMID]:27776220
[Au] Autor:Lynch PA; Boots M
[Ad] Endereço:Department of Biosciences, University of Exeter, Cornwall Campus, Penryn, United Kingdom.
[Ti] Título:Using evolution to generate sustainable malaria control with spatial repellents.
[So] Source:Elife;5, 2016 10 25.
[Is] ISSN:2050-084X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Evolution persistently undermines vector control programs through insecticide resistance. Here we propose a novel strategy which instead exploits evolution to generate and sustain new control tools. Effective spatial repellents are needed to keep vectors out of houses. Our approach generates such new repellents by combining a high-toxicity insecticide with a candidate repellent initially effective against only part of the vector population. By killing mosquitoes that enter treated properties the insecticide selects for vector phenotypes deflected by the repellent, increasing efficacy of the repellent against the target vector population and in turn protecting the insecticide against the spread of insecticide resistance. Using such evolved spatial repellents offers an evolutionarily sustainable, 'double-dip' system of disease control combining mortality and repellence. We formalize this idea using models which explore vector population genetics and disease transmission probabilities and show that using evolved spatial repellents is theoretically achievable, effective and sustainable.
[Mh] Termos MeSH primário: Transmissão de Doença Infecciosa/prevenção & controle
Repelentes de Insetos/farmacologia
Inseticidas/farmacologia
Malária/prevenção & controle
Controle de Mosquitos/métodos
[Mh] Termos MeSH secundário: Seres Humanos
Malária/transmissão
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Insect Repellents); 0 (Insecticides)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171224
[Lr] Data última revisão:
171224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  3 / 2114 MEDLINE  
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[PMID]:29040267
[Au] Autor:Saini RK; Orindi BO; Mbahin N; Andoke JA; Muasa PN; Mbuvi DM; Muya CM; Pickett JA; Borgemeister CW
[Ad] Endereço:International Centre of Insect Physiology and Ecology (icipe), Nairobi, Kenya.
[Ti] Título:Protecting cows in small holder farms in East Africa from tsetse flies by mimicking the odor profile of a non-host bovid.
[So] Source:PLoS Negl Trop Dis;11(10):e0005977, 2017 Oct.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: For the first time, differential attraction of pathogen vectors to vertebrate animals is investigated for novel repellents which when applied to preferred host animals turn them into non-hosts thereby providing a new paradigm for innovative vector control. For effectively controlling tsetse flies (Glossina spp.), vectors of African trypanosomosis, causing nagana, repellents more powerful than plant derived, from a non-host animal the waterbuck, Kobus ellipsiprymnus defassa, have recently been identified. Here we investigate these repellents in the field to protect cattle from nagana by making cattle as unattractive as the buck. METHODOLOGY/PRINCIPAL FINDINGS: To dispense the waterbuck repellents comprising guaiacol, geranylacetone, pentanoic acid and δ-octalactone, (patent application) we developed an innovative collar-mounted release system for individual cattle. We tested protecting cattle, under natural tsetse challenge, from tsetse transmitted nagana in a large field trial comprising 1,100 cattle with repellent collars in Kenya for 24 months. The collars provided substantial protection to livestock from trypanosome infection by reducing disease levels >80%. Protected cattle were healthier, showed significantly reduced disease levels, higher packed cell volume and significantly increased weight. Collars >60% reduced trypanocide use, 72.7% increase in ownership of oxen per household and enhanced traction power (protected animals ploughed 66% more land than unprotected). Land under cultivation increased by 73.4%. Increase in traction power of protected animals reduced by 69.1% acres tilled by hand per household per ploughing season. Improved food security and household income from very high acceptance of collars (99%) motivated the farmers to form a registered community based organization promoting collars for integrated tsetse control and their commercialization. CONCLUSION/SIGNIFICANCE: Clear demonstration that repellents from un-preferred hosts prevent contact between host and vector, thereby preventing disease transmission: a new paradigm for vector control. Evidence that deploying water buck repellents converts cattle into non-hosts for tsetse flies-'cows in waterbuck clothing'.
[Mh] Termos MeSH primário: Doenças dos Bovinos/prevenção & controle
Repelentes de Insetos
Insetos Vetores/fisiologia
Odorantes
Tripanossomíase Africana/veterinária
Moscas Tsé-Tsé/fisiologia
[Mh] Termos MeSH secundário: Criação de Animais Domésticos
Animais
Antílopes
Bovinos
Doenças dos Bovinos/epidemiologia
Doenças dos Bovinos/parasitologia
Quênia/epidemiologia
Tripanossomíase Africana/prevenção & controle
Tripanossomíase Africana/transmissão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insect Repellents)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171018
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005977


  4 / 2114 MEDLINE  
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[PMID]:28981656
[Au] Autor:Wallingford AK; Cha DH; Linn CE; Wolfin MS; Loeb GM
[Ad] Endereço:Department of Entomology, Cornell University, 630 W. North St., Geneva, NY 14456.
[Ti] Título:Robust Manipulations of Pest Insect Behavior Using Repellents and Practical Application for Integrated Pest Management.
[So] Source:Environ Entomol;46(5):1041-1050, 2017 10 01.
[Is] ISSN:1938-2936
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In agricultural settings, examples of effective control strategies using repellent chemicals in integrated pest management (IPM) are relatively scarce compared to those using attractants. This may be partly due to a poor understanding of how repellents affect insect behavior once they are deployed. Here we attempt to identify potential hallmarks of repellent stimuli that are robust enough for practical use in the field. We explore the literature for success stories using repellents in IPM and we investigate the mechanisms of repellency for two chemical oviposition deterrents for controlling Drosophila suzukii Matsumura, a serious pest of small fruit crops. Drosophila suzukii causes injury by laying her eggs in ripening fruit and resulting larvae make fruit unmarketable. In caged choice tests, reduced oviposition was observed in red raspberry fruit treated with volatile 1-octen-3-ol and geosmin at two initial concentrations (10% and 1%) compared to untreated controls. We used video monitoring to observe fly behavior in these caged choice tests and investigate the mode of action for deterrence through the entire behavioral repertoire leading to oviposition. We observed fewer visitors and more time elapsed before flies first landed on 1-octen-3-ol-treated fruits than control fruits and concluded that this odor primarily inhibits behaviors that occur before D. suzukii comes in contact with a potential oviposition substrate (precontact). We observed some qualitative differences in precontact behavior of flies around geosmin-treated fruits; however, we concluded that this odor primarily inhibits behaviors that occur after D. suzukii comes in contact with treated fruits (postcontact). Field trials found reduced oviposition in red raspberry treated with 1-octen-3-ol and a combination of 1-octen-3-ol and geosmin, but no effect of geosmin alone. Recommendations for further study of repellents for practical use in the field are discussed.
[Mh] Termos MeSH primário: Controle de Insetos/métodos
Repelentes de Insetos/farmacologia
Naftóis/farmacologia
Octanóis/farmacologia
Oviposição/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Drosophila
Feminino
Rubus
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Insect Repellents); 0 (Naphthols); 0 (Octanols); MYW912WXJ4 (geosmin); WXB511GE38 (1-octen-3-ol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171126
[Lr] Data última revisão:
171126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171006
[St] Status:MEDLINE
[do] DOI:10.1093/ee/nvx125


  5 / 2114 MEDLINE  
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[PMID]:28859049
[Au] Autor:Prue CE; Roth JN; Garcia-Williams A; Yoos A; Camperlengo L; DeWilde L; Lamtahri M; Prosper A; Harrison C; Witbart L; Guendel I; Wiegand DM; Lamens NR; Hillman B; Davis MS; Ellis EM
[Ti] Título:Awareness, Beliefs, and Actions Concerning Zika Virus Among Pregnant Women and Community Members - U.S. Virgin Islands, November-December 2016.
[So] Source:MMWR Morb Mortal Wkly Rep;66(34):909-913, 2017 Sep 01.
[Is] ISSN:1545-861X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:As of May 2, 2017, the U.S. Virgin Islands (USVI), comprising St. Thomas, St. John, and St. Croix, had reported 1,021 probable or confirmed cases* of Zika virus disease in its population of approximately 100,000 (1); 222 symptomatic and asymptomatic pregnant women in the USVI had tested positive for Zika virus. In January 2016, USVI Department of Health (USVI DOH) initiated Zika response measures, including surveillance, vector control, and a communications program. Interventions included education and outreach, distribution of Zika prevention kits to pregnant women in the USVI, and provision of free Zika virus laboratory testing and vector control services. In November 2016, USVI DOH staff members conducted interviews with convenience samples of community members and pregnant women to gather feedback about current and proposed interventions (2). Pregnant women reported taking a median of two actions to protect themselves from Zika, with repellent use being the most commonly reported action. Community members reported taking a median of one action and were supportive of several proposed vector control approaches. Whereas multiple pregnant women and community members reported hearing messages about the cause and consequences of Zika virus infections, few recalled messages about specific actions they could take to protect themselves. Integrating evaluation into response measures permits ongoing assessment of intervention effectiveness and supports improvement to serve the population's needs.
[Mh] Termos MeSH primário: Conhecimentos, Atitudes e Prática em Saúde
Complicações Infecciosas na Gravidez/prevenção & controle
Gestantes/psicologia
Infecção pelo Zika virus/prevenção & controle
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Repelentes de Insetos
Masculino
Meia-Idade
Controle de Mosquitos
Gravidez
Ilhas Virgens Americanas
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insect Repellents)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.15585/mmwr.mm6634a4


  6 / 2114 MEDLINE  
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[PMID]:28719291
[Au] Autor:Berenson AB; Trinh HN; Hirth JM; Guo F; Fuchs EL; Weaver SC
[Ad] Endereço:Center for Interdisciplinary Research in Women's Health, University of Texas Medical Branch, Galveston, Texas.
[Ti] Título:Knowledge and Prevention Practices among U.S. Pregnant Immigrants from Zika Virus Outbreak Areas.
[So] Source:Am J Trop Med Hyg;97(1):155-162, 2017 Jul.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We administered an anonymous survey to assess knowledge, attitudes, and prevention practices related to the Zika virus among pregnant women residing in Texas. Multivariate logistic regression models controlling for age, race/ethnicity, education, and number of years in the United States assessed differences between women born in outbreak areas ( = 390) versus those born in the United States ( = 249). Results demonstrated that most women wanted more information on the Zika virus and desired to obtain it from their physician. The majority did not know that the Zika virus could be spread through sex with an asymptomatic partner or how often those infected were symptomatic. Few women took precautions to avoid mosquito bites. Only 40% reported frequently using repellent; 21% stated that cost was problematic and almost half were concerned about use during pregnancy. Three-fourths stated they would agree to vaccination, if available. Compared with U.S.-born women, those born in outbreak areas were more likely to have already discussed the Zika virus with their doctor (adjusted odds ratio [aOR] = 1.86, 95% confidence interval [CI] = 1.27, 2.71) and identify microcephaly as the most common birth defect (aOR = 2.59, 95% CI = 1.78, 3.76). Moreover, women born in outbreak areas were less likely to desire to keep it a secret if they became infected (aOR = 0.47, 95% CI = 0.31, 0.71). This study found that, regardless of birthplace, pregnant women need more education on the Zika virus disease and assurance regarding the safety of using repellent during pregnancy. They also need financial assistance for repellent, especially if living in states where transmission by mosquitos has been reported.
[Mh] Termos MeSH primário: Surtos de Doenças/prevenção & controle
Emigrantes e Imigrantes
Conhecimentos, Atitudes e Prática em Saúde
Complicações Infecciosas na Gravidez/prevenção & controle
Complicações Infecciosas na Gravidez/virologia
Infecção pelo Zika virus/prevenção & controle
[Mh] Termos MeSH secundário: Adolescente
Adulto
Animais
Culicidae
Coleta de Dados
Feminino
Seres Humanos
Repelentes de Insetos
Microcefalia/etiologia
Meia-Idade
Controle de Mosquitos
Gravidez
Inquéritos e Questionários
Estados Unidos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insect Repellents)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.17-0062


  7 / 2114 MEDLINE  
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[PMID]:28701652
[Au] Autor:Morimoto M; Urakawa M; Komai K
[Ad] Endereço:Department of Applied Biological Chemistry, School of Agriculture, Kindai University.
[Ti] Título:Electrochemical Synthesis of Dihydrobenzofurans and Evaluation of Their Insect Antifeedant Activities.
[So] Source:J Oleo Sci;66(8):857-862, 2017 Aug 01.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Electrochemically synthesized dihydrobenzofurans were evaluated for their insect antifeedant activities against phytophagous insects. They were prepared through the coupling reactions of various alkenes with a phenoxy cation generated by oxidation near the cathode in the electrolytic reaction. The insect antifeedant activities of these synthetic dihydrobenzofurans were evaluated in the common cutworm (Spodoptera litura) and diamond back moth (Plutella xylostella) with the dual choice leaf disk bioassay method. The insect antifeedant activities of most of the acetophenone-type dihydrobenzofurans were strong, while those of derivatives with a t-butyl group were weaker. The biological activities in insect species differed with the structural features of the compounds.
[Mh] Termos MeSH primário: Benzofuranos/síntese química
Benzofuranos/farmacologia
Técnicas Eletroquímicas
Repelentes de Insetos
Mariposas/efeitos dos fármacos
Spodoptera/efeitos dos fármacos
[Mh] Termos MeSH secundário: Alcenos/química
Animais
Benzofuranos/química
Benzofuranos/classificação
Bioensaio/métodos
Eletrodos
Eletrólise
Oxirredução
Fenóis/química
Plantas/parasitologia
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkenes); 0 (Benzofurans); 0 (Insect Repellents); 0 (Phenols); 3229-70-7 (phenoxy radical)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess17022


  8 / 2114 MEDLINE  
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[PMID]:28594787
[Au] Autor:D'Angelo DV; Salvesen von Essen B; Lamias MJ; Shulman H; Hernandez-Virella WI; Taraporewalla AJ; Vargas MI; Harrison L; Ellington SR; Soto L; Williams T; Rodriguez A; Shapiro-Mendoza CK; Rivera B; Cox S; Pazol K; Rice ME; Dee DL; Romero L; Lathrop E; Barfield W; Smith RA; Jamieson DJ; Honein MA; Deseda C; Warner L
[Ti] Título:Measures Taken to Prevent Zika Virus Infection During Pregnancy - Puerto Rico, 2016.
[So] Source:MMWR Morb Mortal Wkly Rep;66(22):574-578, 2017 Jun 09.
[Is] ISSN:1545-861X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Zika virus infection during pregnancy remains a serious health threat in Puerto Rico. Infection during pregnancy can cause microcephaly, brain abnormalities, and other severe birth defects (1). From January 1, 2016 through March 29, 2017, Puerto Rico reported approximately 3,300 pregnant women with laboratory evidence of possible Zika virus infection (2). There is currently no vaccine or intervention to prevent the adverse effects of Zika virus infection during pregnancy; therefore, prevention has been the focus of public health activities, especially for pregnant women (3). CDC and the Puerto Rico Department of Health analyzed data from the Pregnancy Risk Assessment Monitoring System Zika Postpartum Emergency Response (PRAMS-ZPER) survey conducted from August through December 2016 among Puerto Rico residents with a live birth. Most women (98.1%) reported using at least one measure to avoid mosquitos in their home environment. However, only 45.8% of women reported wearing mosquito repellent daily, and 11.5% reported wearing pants and shirts with long sleeves daily. Approximately one third (38.5%) reported abstaining from sex or using condoms consistently throughout pregnancy. Overall, 76.9% of women reported having been tested for Zika virus by their health care provider during the first or second trimester of pregnancy. These results can be used to assess and refine Zika virus infection prevention messaging and interventions for pregnant women and to reinforce measures to promote prenatal testing for Zika.
[Mh] Termos MeSH primário: Complicações Infecciosas na Gravidez/prevenção & controle
Gestantes/psicologia
Prática de Saúde Pública
Infecção pelo Zika virus/prevenção & controle
[Mh] Termos MeSH secundário: Adulto
Preservativos/utilização
Feminino
Seres Humanos
Repelentes de Insetos
Programas de Rastreamento/estatística & dados numéricos
Controle de Mosquitos/estatística & dados numéricos
Gravidez
Roupa de Proteção/utilização
Porto Rico
Medição de Risco
Abstinência Sexual/estatística & dados numéricos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insect Repellents)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170609
[Lr] Data última revisão:
170609
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170609
[St] Status:MEDLINE
[do] DOI:10.15585/mmwr.mm6622a2


  9 / 2114 MEDLINE  
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[PMID]:28541424
[Au] Autor:Ali A; Cantrell CL; Khan IA
[Ad] Endereço:National Center for Natural Products Research, The University of Mississippi, University, MS 38677.
[Ti] Título:A New In Vitro Bioassay System for the Discovery and Quantitative Evaluation of Mosquito Repellents.
[So] Source:J Med Entomol;54(5):1328-1336, 2017 Sep 01.
[Is] ISSN:1938-2928
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Mosquitoes vector many pathogens that cause human diseases. Repellents play a significant role in reducing the risk of these diseases by preventing mosquito bites. In this paper, we are reporting an Ali and Khan (A & K), large cage in vitro bioassay system that can effectively be used to measure repellency of compounds against mosquitoes. The system uses temperature as a landing and feeding stimulus, and collagen as a feeding substrate. The minimum effective dose (MED) of DEET (N, N-diethyl-meta-toluamide; 19.3 µg/cm2) against Aedes aegypti (L.) in a 30-cm2 treatment area from the A & K bioassay falls in the upper range of the in vivo, cloth patch bioassay (6-23 µg/cm2). Undecanoic acid and geranic acid, with MED values of 3.6 and 7.5 µg/cm2, respectively, in the A & K bioassay were active at 5.5-6.6 times lower dose than that in the in vivo bioassay. Thymol and methyl eugenol with MED values of 11.1 and 10.9 µg/cm2, respectively, were active at 3-4 times lower dose than that in the in vivo bioassay, whereas (-)-trans-p-Menthane-3,8 diol with MED value of 32.3 µg/cm2 was active at 1.3 times lower dose. Comparisons between 12-cm2 and 30-cm2 treatment areas, with similar concentration per unit area in the A & K bioassay, indicated that the MED values at 30 cm2 were 1-2 times higher. In addition to its use to identify the repellent properties of new products, the A & K bioassay can generate useful data on promising repellents to make in vivo testing and field evaluation decisions.
[Mh] Termos MeSH primário: Aedes/efeitos dos fármacos
Bioensaio/métodos
Técnicas In Vitro/métodos
Repelentes de Insetos/farmacologia
[Mh] Termos MeSH secundário: Animais
Colágeno/química
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insect Repellents); 9007-34-5 (Collagen)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1093/jme/tjx100


  10 / 2114 MEDLINE  
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[PMID]:28541143
[Au] Autor:Moss MJ; Maskell KF; Hieger MA; Wills BK; Cumpston KL
[Ad] Endereço:a Department of Emergency Medicine , VCU Medical Center , Richmond , VA , USA.
[Ti] Título:An algorithm for identifying mothball composition .
[So] Source:Clin Toxicol (Phila);55(8):919-921, 2017 Sep.
[Is] ISSN:1556-9519
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Unintentional mothball ingestions may cause serious toxicity in small children. Camphor, naphthalene, and paradichlorobenzene mothballs are difficult to distinguish without packaging. Symptoms and management differ based on the ingested compound. Previous studies have used a variety of antiquated, impractical and potentially dangerous techniques to identify the mothballs. The goal of this study is to discover a simplified identification technique using materials readily available in an emergency department. METHODS: Mothballs made of naphthalene and paradichlorobenzene along with camphor tablets were tested. Each material was tested both intact and after being fragmented to simulate a partially ingested mothball. Each of these six sample types were then immersed in 40 ml each of 11 fluids: water, 0.45% NaCl, 0.9% NaCl, lactated Ringer's, 5% dextrose in water, 5% dextrose in 0.9% NaCl, 50% dextrose in water, 8.4% NaHCO , 3% H O , 70% isopropanol, and 91% isopropanol. All tests were conducted in standard urinalysis sample cups to replicate available materials. Three toxicologists blinded to the identities of samples and solutions visually evaluated each sample. Observations included assessing response to immersion: sink, float, or dissolve. RESULTS: All evaluators agreed in their description of 62/66 (94%) of the samples, with all four disagreements being on sinking and dissolving versus sinking only. A two-fluid algorithm utilizing 50% dextrose and water was sufficient to distinguish the sample types. Camphor will float in water while both paradichlorobenzene and naphthalene will sink. In 50% dextrose, both naphthalene and camphor will float while paradichlorobenzene will sink. CONCLUSION: Mothball materials can be distinguished by immersion in water and 50% dextrose. Limitations of this study include using camphor tablets as a substitute for mothballs given lack of availability.
[Mh] Termos MeSH primário: Algoritmos
Cânfora/análise
Clorobenzenos/análise
Glucose/química
Repelentes de Insetos/análise
Mariposas
Naftalenos/análise
Água/química
[Mh] Termos MeSH secundário: Animais
Cânfora/envenenamento
Clorobenzenos/envenenamento
Liberação Controlada de Fármacos
Repelentes de Insetos/envenenamento
Naftalenos/envenenamento
Variações Dependentes do Observador
Reprodutibilidade dos Testes
Solubilidade
Gravidade Específica
Comprimidos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorobenzenes); 0 (Insect Repellents); 0 (Naphthalenes); 0 (Tablets); 059QF0KO0R (Water); 2166IN72UN (naphthalene); 76-22-2 (Camphor); D149TYB5MK (4-dichlorobenzene); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1080/15563650.2017.1319954



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