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[PMID]:26085334
[Au] Autor:Sheldon S
[Ti] Título:The regulatory cliff edge between contraception and abortion: the legal and moral significance of implantation.
[So] Source:J Med Ethics;41(9):762-5, 2015 Sep.
[Is] ISSN:1473-4257
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In regulating the voluntary interruption of pregnancy, English law has accorded particular significance to two biological events. First, 'viability', the moment when a fetus is said to acquire the capacity for independent life, plays an important role in grounding restrictions on access to legal abortion later in pregnancy. Second, equally significantly but far less frequently discussed, 'implantation' marks the point in pregnancy from which abortion laws apply. This paper focuses on this earlier biological event. It suggests that an unquestioning reliance on implantation as marking an appropriate moment of transition between two radically different legal frameworks is deeply problematic and is rendered still less sustainable in the light of the development of new technologies that potentially operate shortly after the moment of implantation.
[Mh] Termos MeSH primário: Aborto Induzido/legislação & jurisprudência
Início da Vida Humana
Anticoncepção/ética
Anticoncepção/métodos
Anticoncepcionais Femininos/administração & dosagem
Implantação do Embrião
Obrigações Morais
[Mh] Termos MeSH secundário: Aborto Induzido/ética
Aborto Legal/legislação & jurisprudência
Anticoncepcionais Orais/administração & dosagem
Anticoncepcionais Pós-Coito/administração & dosagem
Feminino
Viabilidade Fetal
História do Século XIX
História do Século XX
Seres Humanos
Legislação Médica/história
Legislação Médica/tendências
Indutores da Menstruação/administração & dosagem
Gravidez
Reino Unido
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Contraceptive Agents, Female); 0 (Contraceptives, Oral); 0 (Contraceptives, Postcoital); 0 (Menstruation-Inducing Agents)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:E; IM
[Da] Data de entrada para processamento:150619
[St] Status:MEDLINE
[do] DOI:10.1136/medethics-2015-102712


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[PMID]:23895884
[Au] Autor:Alam A; Bracken H; Johnston HB; Raghavan S; Islam N; Winikoff B; Reichenbach L
[Ad] Endereço:Center of Reproductive Health, icddr,b, Dhaka, Bangladesh.
[Ti] Título:Acceptability and feasibility of mifepristone-misoprostol for menstrual regulation in Bangladesh.
[So] Source:Int Perspect Sex Reprod Health;39(2):79-87, 2013 Jun.
[Is] ISSN:1944-0405
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Annually, more than 700,000 women turn to menstrual regulation, or uterine evacuation with vacuum aspiration; many more resort to unsafe abortion. Using pills for the evacuation of the uterus could increase women's access to safe menstrual regulation services and reduce the high levels of abortion- and menstrual regulation- related morbidity in Bangladesh. METHODS: At 10 facilities in Bangladesh, 651 consenting women who were seeking menstrual regulation services and who were 63 days or less past their last menstrual period received 200 mg of mifepristone followed 24 hours later by 800 mcg of buccal misoprostol, administered either at home or in the clinic. Prospective data were collected to determine women's experience and satisfaction with the procedure, menstrual regulation outcome, and the human and physical resources required for providing the method. Focus group discussions were conducted with a purposively sampled group of service providers at each site to understand their attitudes about the introduction of menstrual regulation with medication. RESULTS: The majority of women (93%) with known menstrual regulation outcomes evacuated the uterus without surgical intervention. Overall, most women (92%) were satisfied with use of pills for their menstrual regulation. Providers faced initial challenges and concerns, particularly related to the additional counseling requirements and lack of control over the final outcome, but became more confident after successful use of the medication regimen. CONCLUSIONS: Mifepristone-misoprostol can be safely offered within existing menstrual regulation services in urban and periurban areas in Bangladesh and is highly acceptable to women. Providers' initial concerns diminish with increased experience with the method.
[Mh] Termos MeSH primário: Abortivos/administração & dosagem
Aborto Induzido/métodos
Indutores da Menstruação/administração & dosagem
Menstruação/efeitos dos fármacos
Mifepristona/administração & dosagem
Misoprostol/administração & dosagem
[Mh] Termos MeSH secundário: Abortivos não Esteroides/administração & dosagem
Adulto
Bangladesh
Feminino
Grupos Focais
Seres Humanos
Satisfação do Paciente
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Abortifacient Agents); 0 (Abortifacient Agents, Nonsteroidal); 0 (Menstruation-Inducing Agents); 0E43V0BB57 (Misoprostol); 320T6RNW1F (Mifepristone)
[Em] Mês de entrada:1402
[Cu] Atualização por classe:130730
[Lr] Data última revisão:
130730
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130731
[St] Status:MEDLINE
[do] DOI:10.1363/3907913


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[PMID]:23223094
[Au] Autor:Pasquier P; Gayat E; Rackelboom T; La Rosa J; Tashkandi A; Tesniere A; Ravinet J; Vincent JL; Tsatsaris V; Ozier Y; Goffinet F; Mignon A
[Ad] Endereço:Bégin Military Teaching Hospital, 69 avenue de Paris 94163 Saint-Mandé Cedex, France. pasquier9606@yahoo.fr
[Ti] Título:An observational study of the fresh frozen plasma: red blood cell ratio in postpartum hemorrhage.
[So] Source:Anesth Analg;116(1):155-61, 2013 Jan.
[Is] ISSN:1526-7598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Postpartum hemorrhage is the leading cause of maternal death worldwide. Recent data from trauma patients and patients with hemorrhagic shock have suggested that an increased fresh frozen plasma:red blood cell (FFP:RBC) ratio may be of benefit in massive bleeding. We addressed this issue in cases of severe postpartum hemorrhage. METHODS: We reviewed data from all patients diagnosed with severe postpartum hemorrhage during a 4-year period (2006-2009). Patients who were treated with sulprostone and required transfusion within 6 hours of delivery were included in the study and were divided into 2 groups according to their response to sulprostone: bleeding controlled with sulprostone alone (sulprostone group) and bleeding requiring an additional advanced interventional procedure including arterial angiographic embolization and/or surgical procedures (arterial ligation, B-Lynch suture, or hysterectomy; intervention group). The requirement or no requirement for advanced procedures constituted the primary end point of the study. Propensity scoring was used to assess the effect of a high FFP:RBC ratio on bleeding control. RESULTS: Among 12,226 deliveries during the study period, 142 (1.1%) were complicated by severe postpartum hemorrhage. Bleeding was controlled with sulprostone alone in 90 patients (63%). Advanced interventional procedures were required for 52 patients (37%). Forty-one patients were transfused with both RBCs and FFP. The FFP:RBC ratio increased over the study period (P < 0.001), from 1:1.8 at the start to 1:1.1 at the end of the study period. After propensity score modeling (inverse probability of treatment weighting), a high FFP:RBC ratio was associated with lower odds for advanced interventional procedures (odds ratio [95% confidence interval], 1.25 [1.07-1.47]; P = 0.008). There were no deaths, severe organ dysfunction, or other complications as a consequence of severe postpartum hemorrhage. CONCLUSIONS: In this retrospective study, a higher FFP:RBC ratio was associated with a lower requirement for advanced interventional procedures in the setting of postpartum hemorrhage. The benefits of transfusion using a higher FFP:RBC ratio should be confirmed by randomized-controlled trials.
[Mh] Termos MeSH primário: Eritrócitos/fisiologia
Plasma
Hemorragia Pós-Parto/sangue
Hemorragia Pós-Parto/terapia
[Mh] Termos MeSH secundário: Adulto
Anestesia Obstétrica
Angiografia
Peso ao Nascer
Cesárea
Dinoprostona/análogos & derivados
Dinoprostona/uso terapêutico
Embolização Terapêutica
Contagem de Eritrócitos
Feminino
Seres Humanos
Recém-Nascido
Indutores da Menstruação/uso terapêutico
Razão de Chances
Hemorragia Pós-Parto/cirurgia
Gravidez
Pontuação de Propensão
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Menstruation-Inducing Agents); 501Q5EQ1GM (sulprostone); K7Q1JQR04M (Dinoprostone)
[Em] Mês de entrada:1302
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:121211
[St] Status:MEDLINE
[do] DOI:10.1213/ANE.0b013e31826f084d


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[PMID]:22648443
[Au] Autor:Li X; Bao Y; Fang P; Chen Y; Qiao Z
[Ad] Endereço:Department of Gynecology and Obstetrics, Shanghai Fifth Hospital, Shanghai 200240, People's Republic of China.
[Ti] Título:Effect of mifepristone on COX-2 both in eutopic and ectopic endometrium in mouse endometriotic model.
[So] Source:Arch Gynecol Obstet;286(4):939-46, 2012 Oct.
[Is] ISSN:1432-0711
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To study the influence of mifepristone on the expression of cyclooxygenase 2 (COX-2) protein and COX-2 mRNA and then to evaluate the mechanism. METHODS: After the establishment of 30 mice endometriosis models, the mice were randomly divided into six groups with 5 mice each group and assigned to experimental and control groups of 1-, 4- and 6-week circle according to whether mifepristone (0.13 mg d(-1)) was taken or not. Small animal optical imaging system was used to detect the fluorescent intensity of the ectopic tissue. Reverse transcript-polymerase chain reaction and western blot was used to examine COX-2 protein and COX-2 mRNA expression. ELISA was used to examine concentration of PGE(2) in serum. RESULT(S): Mifepristone could not affect the fluorescent intensity of the ectopic endometrium after it was taken 1, 4, and 6 (P > 0.05). However, it could decrease the transcription of COX-2 mRNA in the 1 and 4 week groups (P < 0.05), while the difference in the 6 week group was not significant (P > 0.05). It could decrease the expression of COX-2 protein after it was taken 4 and 6 weeks (P < 0.05). The serous PGE(2) in the trial groups was lower than that in the control groups, but the difference was not significant (P > 0.05). CONCLUSION(S): This study showed that mifepristone could not affect the size of the ectopic endometrium, but it could decrease the transcription of COX-2 gene and then reduce the expression of COX-2 protein and its product PGE(2) which is an important factor which mediate pain. This maybe another mechanism that mifepristone takes effect through anti-inflammatory path.
[Mh] Termos MeSH primário: Ciclo-Oxigenase 2/metabolismo
Endometriose/tratamento farmacológico
Endométrio/metabolismo
Indutores da Menstruação/uso terapêutico
Mifepristona/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Dinoprostona/sangue
Avaliação Pré-Clínica de Medicamentos
Endometriose/patologia
Endométrio/patologia
Feminino
Fluorescência
Indutores da Menstruação/farmacologia
Camundongos
Camundongos Endogâmicos C57BL
Mifepristona/farmacologia
RNA Mensageiro/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Menstruation-Inducing Agents); 0 (RNA, Messenger); 320T6RNW1F (Mifepristone); EC 1.14.99.- (Ptgs2 protein, mouse); EC 1.14.99.1 (Cyclooxygenase 2); K7Q1JQR04M (Dinoprostone)
[Em] Mês de entrada:1302
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120601
[St] Status:MEDLINE
[do] DOI:10.1007/s00404-012-2379-2


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[PMID]:22525900
[Au] Autor:Diamond MP; Kruger M; Santoro N; Zhang H; Casson P; Schlaff W; Coutifaris C; Brzyski R; Christman G; Carr BR; McGovern PG; Cataldo NA; Steinkampf MP; Gosman GG; Nestler JE; Carson S; Myers EE; Eisenberg E; Legro RS; Eunice Kennedy Shriver National Institute of Child Health and Human Development Cooperative Reproductive Medicine Network
[Ad] Endereço:Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Wayne State University, Detroit, MI 48201, USA. mdiamond@med.wayne.edu
[Ti] Título:Endometrial shedding effect on conception and live birth in women with polycystic ovary syndrome.
[So] Source:Obstet Gynecol;119(5):902-8, 2012 May.
[Is] ISSN:1873-233X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To estimate whether progestin-induced endometrial shedding, before ovulation induction with clomiphene citrate, metformin, or a combination of both, affects ovulation, conception, and live birth rates in women with polycystic ovary syndrome (PCOS). METHODS: A secondary analysis of the data from 626 women with PCOS from the Eunice Kennedy Shriver National Institute of Child Health and Human Development Cooperative Reproductive Medicine Network trial was performed. Women had been randomized to up to six cycles of clomiphene citrate alone, metformin alone, or clomiphene citrate plus metformin. Women were assessed for occurrence of ovulation, conception, and live birth in relation to prior bleeding episodes (after either ovulation or exogenous progestin-induced withdrawal bleed). RESULTS: Although ovulation rates were higher in cycles preceded by spontaneous endometrial shedding than after anovulatory cycles (with or without prior progestin withdrawal), both conception and live birth rates were significantly higher after anovulatory cycles without progestin-induced withdrawal bleeding (live births per cycle: spontaneous menses 2.2%; anovulatory with progestin withdrawal 1.6%; anovulatory without progestin withdrawal 5.3%; P<.001). The difference was more marked when rate was calculated per ovulation (live births per ovulation: spontaneous menses 3.0%; anovulatory with progestin withdrawal 5.4%; anovulatory without progestin withdrawal 19.7%; P<.001). CONCLUSION: Conception and live birth rates are lower in women with PCOS after a spontaneous menses or progestin-induced withdrawal bleeding as compared with anovulatory cycles without progestin withdrawal. The common clinical practice of inducing endometrial shedding with progestin before ovarian stimulation may have an adverse effect on rates of conception and live birth in anovulatory women with PCOS. LEVEL OF EVIDENCE: II.
[Mh] Termos MeSH primário: Fertilização
Nascimento Vivo
Menstruação
Indução da Ovulação/métodos
Síndrome do Ovário Policístico
Complicações na Gravidez
[Mh] Termos MeSH secundário: Adulto
Clomifeno/administração & dosagem
Método Duplo-Cego
Esquema de Medicação
Combinação de Medicamentos
Feminino
Fármacos para a Fertilidade Feminina/administração & dosagem
Seres Humanos
Menstruação/efeitos dos fármacos
Indutores da Menstruação/administração & dosagem
Indutores da Menstruação/farmacologia
Metformina/administração & dosagem
Ovulação
Gravidez
Progestinas/administração & dosagem
Progestinas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Drug Combinations); 0 (Fertility Agents, Female); 0 (Menstruation-Inducing Agents); 0 (Progestins); 1HRS458QU2 (Clomiphene); 9100L32L2N (Metformin)
[Em] Mês de entrada:1207
[Cu] Atualização por classe:161019
[Lr] Data última revisão:
161019
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:120425
[St] Status:MEDLINE
[do] DOI:10.1097/AOG.0b013e31824da35c


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[PMID]:22412950
[Au] Autor:Rudolph M; Döcke WD; Müller A; Menning A; Röse L; Zollner TM; Gashaw I
[Ad] Endereço:Target Discovery, Global Drug Discovery, Bayer HealthCare, Berlin, Germany. marion.rudolph@bayer.com
[Ti] Título:Induction of overt menstruation in intact mice.
[So] Source:PLoS One;7(3):e32922, 2012.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The complex tissue remodeling process of menstruation is experienced by humans and some primates, whereas most placental mammals, including mice, go through an estrous cycle. How menstruation and the underlying mechanisms evolved is still unknown. Here we demonstrate that the process of menstruation is not just species-specific but also depends on factors which can be induced experimentally. In intact female mice endogenous progesterone levels were raised by the induction of pseudopregnancy. Following an intrauterine oil injection, the decidualization of the endometrium was reliably induced as a prerequisite for menstruation. The natural drop of endogenous progesterone led to spontaneous breakdown of endometrial tissue within an average of 3 days post induction of decidualization. Interestingly, morphological changes such as breakdown and repair of the endometrial layer occurred in parallel in the same uterine horn. Most importantly, endometrial breakdown was accompanied by vaginally visible (overt) bleeding and flushing out of shed tissue comparable to human menstruation. Real-time PCR data clearly showed temporal changes in the expression of multiple factors participating in inflammation, angiogenesis, tissue modulation, proliferation, and apoptosis, as has been described for human menstruating endometrium. In conclusion, human menstruation can be mimicked in terms of extravaginally visible bleeding, tissue remodeling, and gene regulation in naturally non-menstruating species such as intact female mice without the need for an exogenous hormone supply.
[Mh] Termos MeSH primário: Estro/efeitos dos fármacos
Indutores da Menstruação/farmacologia
Mifepristona/farmacologia
[Mh] Termos MeSH secundário: Animais
Decídua/citologia
Decídua/efeitos dos fármacos
Decídua/fisiologia
Endométrio/efeitos dos fármacos
Endométrio/fisiologia
Ciclo Estral/efeitos dos fármacos
Ciclo Estral/fisiologia
Estro/fisiologia
Feminino
Regulação da Expressão Gênica/efeitos dos fármacos
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Progesterona/metabolismo
Pseudogravidez
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Menstruation-Inducing Agents); 0 (RNA, Messenger); 320T6RNW1F (Mifepristone); 4G7DS2Q64Y (Progesterone)
[Em] Mês de entrada:1208
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120314
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0032922


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[PMID]:22245754
[Au] Autor:Kumar D; Kumar A; Prakash O
[Ad] Endereço:Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, Harynana, India. dineshbarbola@yahoo.co.in
[Ti] Título:Potential antifertility agents from plants: a comprehensive review.
[So] Source:J Ethnopharmacol;140(1):1-32, 2012 Mar 06.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Traditional medicines are practiced worldwide for regulation fertility since ancient times. This review provides a comprehensive summary of medicinal flora inhabitating throughout the world regarding their traditional usage by various tribes/ethnic groups for fertility regulation in females. MATERIALS AND METHODS: Bibliographic investigation was carried out by analyzing classical text books and peer reviewed papers, consulting worldwide accepted scientific databases from the last six decades. Plants/their parts/extracts traditionally used for abortion, contraception, emmenagogue and sterilization purposes have been considered as antifertility agents. Research status of selected potential plant species has been discussed. Further, compounds isolated from plants with attributed fertility regulating potentials are also classified into three categories: (a) phytoconstituents with anti-implantation activity, (b) phytoconstituents with abortifacient activity and (c) phytoconstituents with contraceptive activity. RESULTS: 577 plant species belonging to 122 families, traditionally used in fertility regulation in females, have been recorded, of which 298 plants have been mentioned as abortifacients (42%), 188 as contraceptives (31%), 149 as emmenagogues (24%), and 17 as sterilizers. Among 122 plant families, fabaceae constitutes 49.2%, asteraceae 40.98%, euphorbiaceae 19.7%, apiaceae 16.4%, poaceae 12.3%, labiateae 11.5%, and others in lesser proportion. Various plant parts used in fertility regulation include leaves (25%), roots (22%), fruits (15%), seeds (12%), stem/stem bark (37%), and flowers (4%). Some active compounds, isolated from about various plant species, have been reported to possess significant antifertility potential. CONCLUSION: This review clearly indicates that it is time to increase the number of experimental studies to find out novel potential chemical entities from such a vast array of unexploited plants having traditional role in fertility regulation. Also, the mechanisms of action by which plant extracts and their active compounds exert antifertility effects remain to be studied.
[Mh] Termos MeSH primário: Abortivos
Anticoncepcionais
Etnofarmacologia
Fertilidade/efeitos dos fármacos
Indutores da Menstruação
Fitoterapia
Plantas/química
[Mh] Termos MeSH secundário: Anticoncepção
Feminino
Seres Humanos
Infertilidade
Extratos Vegetais/farmacologia
Estruturas Vegetais
Gravidez
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Abortifacient Agents); 0 (Contraceptive Agents); 0 (Menstruation-Inducing Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1207
[Cu] Atualização por classe:120220
[Lr] Data última revisão:
120220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120117
[St] Status:MEDLINE
[do] DOI:10.1016/j.jep.2011.12.039


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[PMID]:22008360
[Au] Autor:Naiditch JA; Milad MP; Rowell EE
[Ad] Endereço:Division of Pediatric Surgery, Children's Memorial Hospital, Chicago, IL 60614-3363, USA. jnaiditch@childrensmemorial.org
[Ti] Título:Uterine leiomyoma causing menometrorrhagia with a concomitant mature teratoma in a 15-year-old child: a case report and review of the literature.
[So] Source:J Pediatr Surg;46(10):E33-6, 2011 Oct.
[Is] ISSN:1531-5037
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Uterine leiomyoma is the most common uterine tumor in adult females but is rare in the pediatric population with only 10 previous cases reported. We describe the unique case of a 15-year-old girl who presented with abdominal pain and menometrorrhagia and was found to have a uterine leiomyoma as well as a mature ovarian teratoma that required surgical resection. We review diagnostic imaging and optimal management for the 2 gynecologic masses in this teenage girl.
[Mh] Termos MeSH primário: Leiomioma/complicações
Menorragia/etiologia
Metrorragia/etiologia
Neoplasias Primárias Múltiplas/diagnóstico
Neoplasias Ovarianas/diagnóstico
Teratoma/diagnóstico
Neoplasias Uterinas/complicações
[Mh] Termos MeSH secundário: Dor Abdominal/etiologia
Adolescente
Assistência ao Convalescente
Feminino
Seres Humanos
Laparotomia
Leiomioma/diagnóstico
Leiomioma/cirurgia
Indutores da Menstruação/uso terapêutico
Neoplasias Ovarianas/cirurgia
Ovário/cirurgia
Prognóstico
Teratoma/cirurgia
Neoplasias Uterinas/diagnóstico
Neoplasias Uterinas/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Menstruation-Inducing Agents)
[Em] Mês de entrada:1203
[Cu] Atualização por classe:111019
[Lr] Data última revisão:
111019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:111020
[St] Status:MEDLINE
[do] DOI:10.1016/j.jpedsurg.2011.06.031


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[PMID]:19733052
[Au] Autor:Dupont C; Touzet S; Colin C; Deneux-Tharaux C; Rabilloud M; Clement HJ; Lansac J; Colle MH; Rudigoz RC; Groupe PITHAGORE 6
[Ad] Endereço:Healthcare Practices Assessment Unit, Pole IMER des Hospices Civils de Lyon, 162, avenue Lacassagne, 69424 Lyon cedex 03, France. corinne.dupont@chu-lyon.fr
[Ti] Título:Incidence and management of postpartum haemorrhage following the dissemination of guidelines in a network of 16 maternity units in France.
[So] Source:Int J Obstet Anesth;18(4):320-7, 2009 Oct.
[Is] ISSN:1532-3374
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In France obstetric haemorrhage is the leading cause of maternal death. The aim of this study was to evaluate if the management of postpartum haemorrhage at individual maternity units followed guidelines established by the Aurore Network. METHODS: A descriptive study was carried out in 16 maternity units of the Aurore network between October 2004 and September 2005. Cases and data were prospectively identified and collected. RESULTS: Postpartum haemorrhage occurred in 1144 of 21 350 deliveries, an overall incidence of 5.4+/-0.3%. Of these, 316 cases were rated as severe. Diagnosis was clinical in 82.5% of severe cases and 77.5% of non-severe cases; the remainder were detected by postpartum laboratory tests. Uterotonic agents were given prophylactically to 46.7% of the 896 patients following vaginal delivery. In cases in which postpartum haemorrhage was due to uterine atony, 83.1% of women underwent examination of the uterine cavity and 96.3% received oxytocin, which proved therapeutic. Sulprostone was administered to 39.5% cases of persistent postpartum haemorrhage. A uterotonic was given prophylactically to 85.4% of the 247 patients at caesarean delivery. Oxytocin was therapeutic in 94.8% of cases of uterine atony. Sulprostone was administered in 84.4% of cases of persistent postpartum haemorrhage. CONCLUSION: The regional guidelines issued by the Aurore network were only partially followed. More effective guideline dissemination and implementation is required to improve the prevention and management of confirmed haemorrhage.
[Mh] Termos MeSH primário: Hemorragia Pós-Parto/terapia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Cesárea
Parto Obstétrico
Dinoprostona/análogos & derivados
Dinoprostona/uso terapêutico
Feminino
França/epidemiologia
Fidelidade a Diretrizes
Guias como Assunto
Hemoglobinas/análise
Hemoglobinas/metabolismo
Seres Humanos
Recém-Nascido
Indutores da Menstruação/uso terapêutico
Ocitócicos/uso terapêutico
Ocitocina/uso terapêutico
Hemorragia Pós-Parto/epidemiologia
Hemorragia Pós-Parto/prevenção & controle
Guias de Prática Clínica como Assunto
Gravidez
Estudos Prospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Hemoglobins); 0 (Menstruation-Inducing Agents); 0 (Oxytocics); 50-56-6 (Oxytocin); 501Q5EQ1GM (sulprostone); K7Q1JQR04M (Dinoprostone)
[Em] Mês de entrada:0912
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090908
[St] Status:MEDLINE
[do] DOI:10.1016/j.ijoa.2009.02.017


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[PMID]:18928984
[Au] Autor:Ruddock NK; Shi SQ; Jain S; Moore G; Hankins GD; Romero R; Garfield RE
[Ad] Endereço:Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA.
[Ti] Título:Progesterone, but not 17-alpha-hydroxyprogesterone caproate, inhibits human myometrial contractions.
[So] Source:Am J Obstet Gynecol;199(4):391.e1-7, 2008 Oct.
[Is] ISSN:1097-6868
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The aim was to determine whether progesterone (P4) or 17-alpha-hydroxyprogesterone caproate (17P) directly inhibit human uterine contractility in vitro and thereby clarify their mechanisms of action. STUDY DESIGN: Myometrial tissues were suspended in organ chambers and exposed for 2 to 20 hours to varying concentrations of P4 or 17P or solvent. Contractile activity was registered, stored, and analyzed. Dose response curves were then generated for P4 or 17P at various times. RESULTS: P4 significantly inhibited spontaneous contractility dose dependently. The inhibition was not blocked by RU486 but was reversible after washing. Surprisingly, 17P dose dependently stimulated contractility. HPLC and GC-MS methods were used to determine the detectable concentrations of progestins in the baths. CONCLUSION: P4, at concentrations equivalent to those present in the placenta and uterus, inhibit spontaneous myometrial contractility in vitro by nongenomic mechanisms.
[Mh] Termos MeSH primário: 17-alfa-Hidroxiprogesterona/farmacologia
Miométrio/efeitos dos fármacos
Progesterona/farmacologia
Progestinas/farmacologia
Contração Uterina/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adulto
Cromatografia Líquida de Alta Pressão
Relação Dose-Resposta a Droga
Feminino
Seres Humanos
Técnicas In Vitro
Concentração Inibidora 50
Indutores da Menstruação/farmacologia
Mifepristona/farmacologia
Miométrio/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Menstruation-Inducing Agents); 0 (Progestins); 320T6RNW1F (Mifepristone); 4G7DS2Q64Y (Progesterone); 68-96-2 (17-alpha-Hydroxyprogesterone)
[Em] Mês de entrada:0811
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:081022
[St] Status:MEDLINE
[do] DOI:10.1016/j.ajog.2008.06.085



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