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Pesquisa : D27.505.696.875.360.443 [Categoria DeCS]
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[PMID]:28910430
[Au] Autor:Rubin R
[Ti] Título:Work Progresses on Male Contraceptives, but Hurdles Remain.
[So] Source:JAMA;318(13):1208-1210, 2017 Oct 03.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Anticoncepcionais Masculinos
Descoberta de Drogas
[Mh] Termos MeSH secundário: Animais
Antiespermatogênicos
Anticoncepcionais Masculinos/efeitos adversos
Anticoncepcionais Masculinos/economia
Indústria Farmacêutica
Géis
Seres Humanos
Masculino
Marketing de Serviços de Saúde
National Institute of Child Health and Human Development (U.S.)
Apoio à Pesquisa como Assunto
Estados Unidos
[Pt] Tipo de publicação:NEWS
[Nm] Nome de substância:
0 (Antispermatogenic Agents); 0 (Contraceptive Agents, Male); 0 (Gels)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.10302


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[PMID]:28189123
[Au] Autor:Zitzmann M; Rohayem J; Raidt J; Kliesch S; Kumar N; Sitruk-Ware R; Nieschlag E
[Ad] Endereço:Institute of Reproductive Medicine, University Clinics, Muenster, Germany.
[Ti] Título:Impact of various progestins with or without transdermal testosterone on gonadotropin levels for non-invasive hormonal male contraception: a randomized clinical trial.
[So] Source:Andrology;5(3):516-526, 2017 May.
[Is] ISSN:2047-2927
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Although several progestins have been tested for hormonal male contraception, the effects of dosage and nature of various progestins on gonadotropin suppression combined with and without additional testosterone has not been performed in a comparative trial. The aim of this study was to evaluate the differential impact of four oral or transdermal progestins on the suppression of gonadotropins in healthy men: oral: cyproterone acetate (CPA), levonorgestrel (LNG), norethisterone acetate (NETA), and transdermal: Nestorone (NES), all in combination with transdermal testosterone (T). Randomized clinical trial testing was performed with four progestins at two doses each. After a 2-week progestin-only treatment, transdermal T was added for further 4 weeks and was followed by a 3-week recovery period. Progestin-dose per day: CPA 10 mg/20 mg, NES 2 mg/3 mg/dose e.g. 200/300 µg/day absorbed, NETA 5 mg/10 mg, LNG 120 µg/240 µg. From an andrology outpatient clinic, 56 healthy men aged 18-50 years, with body mass index ≤33 kg × m were included in the study. Serum concentrations of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were studied. Secondary outcome measure included were serum testosterone concentrations, sperm concentrations, and safety parameters. Intergroup comparisons demonstrated that CPA and LNG had the strongest effect on LH/FSH suppression. Nevertheless, every substance showed significant inhibitory effects on gonadotropin secretion, especially in combination with transdermal T. A decrease in hematocrit and insulin sensitivity as well as cholesterol subfractions and triglycerides was uniformly seen for every group. The combination of oral or transdermal progestins with a transdermal testosterone preparation is able to suppress gonadotropins. Further dose titration studies with sperm suppression as an end-point should be conducted to determine the lowest effective dose for hormonal male contraception.
[Mh] Termos MeSH primário: Anticoncepcionais Masculinos/administração & dosagem
Acetato de Ciproterona/administração & dosagem
Levanogestrel/administração & dosagem
Noretindrona/análogos & derivados
Norprogesteronas/administração & dosagem
Testosterona/administração & dosagem
[Mh] Termos MeSH secundário: Adolescente
Adulto
Anticoncepção/métodos
Anticoncepcionais Masculinos/efeitos adversos
Acetato de Ciproterona/efeitos adversos
Hormônio Foliculoestimulante/sangue
Seres Humanos
Levanogestrel/efeitos adversos
Hormônio Luteinizante/sangue
Masculino
Meia-Idade
Noretindrona/administração & dosagem
Noretindrona/efeitos adversos
Norprogesteronas/efeitos adversos
Progestinas
Espermatozoides/efeitos dos fármacos
Testosterona/efeitos adversos
Testosterona/sangue
Adesivo Transdérmico
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Contraceptive Agents, Male); 0 (Norprogesterones); 0 (Progestins); 3XMK78S47O (Testosterone); 4KM2BN5JHF (Cyproterone Acetate); 5W7SIA7YZW (Levonorgestrel); 7759-35-5 (ST 1435); 9002-67-9 (Luteinizing Hormone); 9002-68-0 (Follicle Stimulating Hormone); 9S44LIC7OJ (norethindrone acetate); T18F433X4S (Norethindrone)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170212
[St] Status:MEDLINE
[do] DOI:10.1111/andr.12328


  3 / 1173 MEDLINE  
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[PMID]:28093975
[Au] Autor:Sarma K; Roychoudhury S; Bora SS; Dehury B; Parida P; Das S; Das R; Dohutia C; Nath S; Deb B; Modi MK
[Ad] Endereço:Department of Life Science and Bioinformatics, Assam University, Silchar 788011, Assam. India.
[Ti] Título:Molecular Modeling and Dynamics Simulation Analysis of KATNAL1 for Identification of Novel Inhibitor of Sperm Maturation.
[So] Source:Comb Chem High Throughput Screen;20(1):82-92, 2017.
[Is] ISSN:1875-5402
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Hormone based birth control often causes various side effects. A recent study revealed that temporary infertility without changing hormone levels can be attained by inhibiting Katanin p60 ATPase-containing subunit A-like 1 protein (KATNAL1) which is critical for sperm maturation in the testes. OBJECTIVE: This study aimed at attaining the most energetically stable three dimensional (3D) structure of KATNAL1 protein using comparative modeling followed by screening of a ligand library of known natural spermicidal compounds for their binding affinity with KATNAL1. This in turn may inhibit the development of mature sperm in the seminiferous epithelium. METHOD: A series of computational techniques were used for building the 3D structure of KATNAL1 which was further optimized by molecular dynamics (MD) simulation. For revealing the ATP binding mode of KATNAL1, docking study was carried out using the optimized model obtained from the MD simulation. The docking study was also employed to test the binding efficiency of the ligand library. RESULTS: Molecular docking study confirmed the ATP binding of KATNAL1 with various hydrophobic and hydrogen bond interactions. Binding efficiency of the ligand library suggested that calotropin, a cardenolide of Calotropis procera showed the highest binding efficiency against the target protein without toxicity. MD simulation of the docked complex validated the results of the docking study. CONCLUSION: This study revealed the ATP binding mode of KATNAL1 and identified calotropin as a potential lead molecule against it showing high binding efficiency with good bioavailability and no mutagenicity. Further in vitro and in vivo bioassay of calotropin could facilitate the development of novel non-hormonal male-specific contraceptive in near future.
[Mh] Termos MeSH primário: Adenosina Trifosfatases/antagonistas & inibidores
Adenosina Trifosfatases/metabolismo
Anticoncepcionais Masculinos/farmacologia
Descoberta de Drogas
Maturação do Esperma/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adenosina Trifosfatases/química
Trifosfato de Adenosina/metabolismo
Sítios de Ligação
Cardenolídeos/farmacologia
Seres Humanos
Katanina
Ligantes
Masculino
Simulação de Acoplamento Molecular
Simulação de Dinâmica Molecular
Ligação Proteica
Relação Quantitativa Estrutura-Atividade
Bibliotecas de Moléculas Pequenas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cardenolides); 0 (Contraceptive Agents, Male); 0 (Ligands); 0 (Small Molecule Libraries); 0 (calotropin); 8L70Q75FXE (Adenosine Triphosphate); EC 3.6.1.- (Adenosine Triphosphatases); EC 3.6.4.3 (KATNAL1 protein, human); EC 3.6.4.3 (Katanin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170118
[St] Status:MEDLINE
[do] DOI:10.2174/1386207320666170116120104


  4 / 1173 MEDLINE  
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[PMID]:27671782
[Au] Autor:Rea JA; Dixon MR; Zettle RD; Wright KL
[Ad] Endereço:Parsons State Hospital and Training Center, 2601 Gabriel, Parsons, KS, 67357, USA. Jerry.Rea@pshtc.ks.gov.
[Ti] Título:The Development of In Vivo Measures to Assess the Impact of Sex-Drive Reducing Medications in an Offender with an Intellectual Disability.
[So] Source:Arch Sex Behav;46(3):843-859, 2017 Apr.
[Is] ISSN:1573-2800
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The ability to adequately evaluate medications in the treatment of paraphilias has been limited by reliance upon self-report as a measure of effectiveness over periods of time that may be too short to detect reoffending. One solution to this shortcoming is the development of valid, long-term, stable assessment measures. The purpose of this case study was to analyze the effects of Prozac and Provera on an array of behaviors germane to the successful treatment of paraphilias, including: (a) sexual arousal in the laboratory and natural environment, (b) sexual thoughts (deviant and nondeviant) accompanied by arousal in the natural environment, and (c) overt actions in the community associated with increased risk of reoffending over a 31-month period for an exhibitionist with an intellectual disability. Despite the ineffectiveness of the medications, the measures demonstrated long-term, differentiated significant clinical responding; further underscored the importance of assessing deviant sexual arousal and adherence to relapse-prevention procedures in the natural environment; and provided a new methodology to assess sexual preoccupations and sexual arousal. Use of these in vivo measures raises questions regarding their potential to improve the predictability of risk assessments, and serve as an aide in the analysis of whether a treatment procedure is effective for an individual.
[Mh] Termos MeSH primário: Criminosos
Exibicionismo
Deficiência Intelectual/complicações
Libido/efeitos dos fármacos
Medição de Risco/métodos
Delitos Sexuais/prevenção & controle
[Mh] Termos MeSH secundário: Adulto
Anticoncepcionais Masculinos/farmacologia
Anticoncepcionais Masculinos/uso terapêutico
Exibicionismo/tratamento farmacológico
Exibicionismo/prevenção & controle
Fluoxetina/farmacologia
Fluoxetina/uso terapêutico
Seres Humanos
Masculino
Acetato de Medroxiprogesterona/farmacologia
Acetato de Medroxiprogesterona/uso terapêutico
Psicometria
Comportamento Sexual/efeitos dos fármacos
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contraceptive Agents, Male); 01K63SUP8D (Fluoxetine); C2QI4IOI2G (Medroxyprogesterone Acetate)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160928
[St] Status:MEDLINE
[do] DOI:10.1007/s10508-016-0832-1


  5 / 1173 MEDLINE  
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[PMID]:26763267
[Au] Autor:Romagnoli S; Baldan A; Righetti C; Milani C; Mollo A; Stelletta C
[Ad] Endereço:Department of Animal Medicine, Production and Health, University of Padova, Padova, Italy.
[Ti] Título:Semen quality and interval to sterility in tom cats treated with a 9.4 mg deslorelin implant.
[So] Source:J Feline Med Surg;19(2):194-199, 2017 Feb.
[Is] ISSN:1532-2750
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objectives Gonadotropin-releasing hormone (GnRH) agonists like deslorelin are being increasingly used in tom cats for their efficacy in controlling reproductive behaviour and fertility. Deslorelin implants have been widely available in Europe since 2008. Little, if anything, is known about the interval between treatment and onset of sterility, as well as semen quality, after treatment in tom cats. The purpose of this study was to investigate semen quality and interval to sterility in tom cats treated with a 9.4 mg deslorelin implant. Methods Fifteen healthy adult tom cats were treated with a 9.4 mg deslorelin implant (Suprelorin 12). For each cat, semen collection and a GnRH stimulation test (intramuscular administration of 50 µg gonadorelin [Fertagyl], followed by blood sampling 1 h later, to assay serum testosterone) were performed on the first consultation and then repeated every 15 days until complete sterility was achieved. Semen collection was performed by introducing a 14 cm, open-end feline catheter (Argyle) 9 cm into the distal urethra 10 mins after sedation by intramuscular injection of 100 µg/kg medetomidine (Domitor). Results Semen collection was not successful in all cats at each attempt. In the first month after treatment, the semen of only four cats could be evaluated, while the semen of eight cats could be evaluated during the second and third months of the study. Semen quality (ejaculate volume, progressive motility and morphological abnormalities) improved slightly during the first 19-25 days in 2/4 cats, and in 1/4 cats motility was still very high (80%) 25 days post-treatment (PT), but we have no data regarding fertility prior to treatment in this cat. The last cat never produced spermatozoa. Subsequently, semen quality gradually worsened in all cats from 30 days onwards. At 70 days PT, one cat was still potentially fertile. After 72 days all cats were sterile. Conclusions and relevance Semen quality increased slightly in treated cats during the first month after treatment, and then gradually decreased over the following months. Complete sterility was reached within 40-72 days following implantation.
[Mh] Termos MeSH primário: Implantes de Medicamento
Infertilidade Masculina/induzido quimicamente
Infertilidade/veterinária
Análise do Sêmen/veterinária
[Mh] Termos MeSH secundário: Animais
Doenças do Gato/tratamento farmacológico
Gatos
Anticoncepção/veterinária
Anticoncepcionais Masculinos/administração & dosagem
Masculino
Sêmen
Comportamento Sexual Animal
Pamoato de Triptorrelina/análogos & derivados
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contraceptive Agents, Male); 0 (Drug Implants); 57773-63-4 (Triptorelin Pamoate); TKG3I66TVE (deslorelin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160115
[St] Status:MEDLINE
[do] DOI:10.1177/1098612X15623985


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[PMID]:27678037
[Au] Autor:Amory JK
[Ad] Endereço:Center for Research in Reproduction and Contraception, Department of Medicine, University of Washington, Seattle, Washington. Electronic address: jamory@u.washington.edu.
[Ti] Título:Male contraception.
[So] Source:Fertil Steril;106(6):1303-1309, 2016 Nov.
[Is] ISSN:1556-5653
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Although female contraceptives are very effective at preventing unintended pregnancy, some women can not use them because of health conditions or side-effects, leaving some couples without effective contraceptive options. In addition, many men wish to take active responsibility for family planning. Thus, there is a great need for male contraceptives to prevent unintended pregnancies, of which 80-90 million occur annually. At present, effective male contraceptive options are condoms and vasectomy, which are not ideal for all men. Therefore, efforts are under way to develop novel male contraceptives. This paper briefly reviews the advantages and disadvantages of condoms and vasectomies and then discusses the research directed toward development of novel methods of male contraception.
[Mh] Termos MeSH primário: Preservativos
Anticoncepção/métodos
Anticoncepcionais Masculinos/administração & dosagem
Serviços de Planejamento Familiar
Fertilidade/efeitos dos fármacos
Gravidez não Planejada
Vasectomia
[Mh] Termos MeSH secundário: Preservativos/efeitos adversos
Anticoncepção/efeitos adversos
Anticoncepção/instrumentação
Anticoncepcionais Masculinos/efeitos adversos
Feminino
Seres Humanos
Masculino
Gravidez
Medição de Risco
Fatores de Risco
Vasectomia/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Contraceptive Agents, Male)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160929
[St] Status:MEDLINE


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[PMID]:27545067
[Au] Autor:Lishko PV
[Ad] Endereço:Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA. Electronic address: lishko@berkeley.edu.
[Ti] Título:Contraception: Search for an Ideal Unisex Mechanism by Targeting Ion Channels.
[So] Source:Trends Biochem Sci;41(10):816-8, 2016 Oct.
[Is] ISSN:0968-0004
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Targeting sperm ion channels and other sperm-specific proteins is an effective way to develop unisex contraceptives, as they should have decreased side effects. This Science & Society summarizes the current advances in human sperm physiology in attempts to evaluate what would be appropriate targets for unisex contraceptives.
[Mh] Termos MeSH primário: Canais de Cálcio/genética
Anticoncepcionais Masculinos/farmacologia
Subunidades alfa do Canal de Potássio Ativado por Cálcio de Condutância Alta/genética
ATPase Trocadora de Sódio-Potássio/genética
Motilidade Espermática/efeitos dos fármacos
Espermatozoides/efeitos dos fármacos
[Mh] Termos MeSH secundário: Cálcio/metabolismo
Canais de Cálcio/metabolismo
Anticoncepção/métodos
Fertilização/efeitos dos fármacos
Expressão Gênica
Seres Humanos
Subunidades alfa do Canal de Potássio Ativado por Cálcio de Condutância Alta/antagonistas & inibidores
Subunidades alfa do Canal de Potássio Ativado por Cálcio de Condutância Alta/metabolismo
Masculino
Óvulo/efeitos dos fármacos
ATPase Trocadora de Sódio-Potássio/antagonistas & inibidores
ATPase Trocadora de Sódio-Potássio/metabolismo
Capacitação Espermática/efeitos dos fármacos
Espermatozoides/citologia
Espermatozoides/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (CATSPER1 protein, human); 0 (Calcium Channels); 0 (Contraceptive Agents, Male); 0 (KCNMA1 protein, human); 0 (Large-Conductance Calcium-Activated Potassium Channel alpha Subunits); EC 3.6.1.- (ATP1A4 protein, human); EC 3.6.3.9 (Sodium-Potassium-Exchanging ATPase); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171001
[Lr] Data última revisão:
171001
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160823
[St] Status:MEDLINE


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[PMID]:27530737
[Au] Autor:Bitzer J; Serfaty D
[Ti] Título:Editorial.
[So] Source:Eur J Contracept Reprod Health Care;21(5):337-8, 2016 Oct.
[Is] ISSN:1473-0782
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Anticoncepção
Serviços de Planejamento Familiar
Pesquisa
[Mh] Termos MeSH secundário: Anticoncepcionais Masculinos
Dispositivos Anticoncepcionais Masculinos
Prioridades em Saúde
Necessidades e Demandas de Serviços de Saúde
Seres Humanos
[Pt] Tipo de publicação:EDITORIAL
[Nm] Nome de substância:
0 (Contraceptive Agents, Male)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170503
[Lr] Data última revisão:
170503
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160818
[St] Status:MEDLINE
[do] DOI:10.1080/13625187.2016.1212187


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[PMID]:27523300
[Au] Autor:Blithe DL
[Ad] Endereço:Contraception Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland. Electronic address: blithed@nih.gov.
[Ti] Título:Pipeline for contraceptive development.
[So] Source:Fertil Steril;106(6):1295-1302, 2016 Nov.
[Is] ISSN:1556-5653
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The high rates of unplanned pregnancy reflect an unmet need for effective contraceptive methods for women, especially for individuals with health risks such as obesity, diabetes, hypertension, and other conditions that may contraindicate use of an estrogen-containing product. Improvements in safety, user convenience, acceptability, and availability of products remain important goals of the contraceptive development program. Another important goal is to minimize the impact of the products on the environment. Development of new methods for male contraception has the potential to address many of these issues of safety for women who have contraindications to effective contraceptive methods but want to protect against pregnancy. It would also address a huge unmet need for men who want to control their fertility. Products under development for men would not introduce ecotoxic hormones into the water system.
[Mh] Termos MeSH primário: Anticoncepção/tendências
Anticoncepcionais Femininos/administração & dosagem
Anticoncepcionais Masculinos/administração & dosagem
Descoberta de Drogas/tendências
Serviços de Planejamento Familiar/tendências
Fertilidade/efeitos dos fármacos
[Mh] Termos MeSH secundário: Anticoncepção/efeitos adversos
Anticoncepcionais Femininos/efeitos adversos
Anticoncepcionais Masculinos/efeitos adversos
Feminino
Previsões
Química Verde/tendências
Seres Humanos
Masculino
Gravidez
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Contraceptive Agents, Female); 0 (Contraceptive Agents, Male)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160816
[St] Status:MEDLINE


  10 / 1173 MEDLINE  
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[PMID]:27109577
[Au] Autor:Amaral S; S Tavares R; Baptista M; Sousa MI; Silva A; Escada-Rebelo S; Paiva CP; Ramalho-Santos J
[Ad] Endereço:Center for Neuroscience and Cell Biology, University of Coimbra, 3001-517 Coimbra, Portugal.. scgamaral@gmail.com.
[Ti] Título:Mitochondrial Functionality and Chemical Compound Action on Sperm Function.
[So] Source:Curr Med Chem;23(31):3575-3606, 2016.
[Is] ISSN:1875-533X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:During the last decade, several studies have shown that mitochondrial parameters, such as integrity, respiratory activity, membrane potential and ROS production are intimately linked with sperm quality. Given the limitations of conventional semen analyses in terms of predicting male fertility, an increasing number of studies are focusing on the characterization of sperm mitochondria in order to more accurately assess sperm functionality. Moreover, mitochondria from several organs, such as the liver, have been described as a powerful screening tool for drug safety, being an easy in vitro model to assess the toxicity of distinct families of compounds. Given that mitochondrial functionality is intimately related to sperm homeostasis, it has become important to understand how compounds, ranging from dietary supplements, environmental pollutants, dependency-inducing drugs to pharmacological agents (such as erectile dysfunction-targeted drugs and male contraceptives) affect sperm mitochondrial function. In this review, we discuss studies describing the effects of various chemical agents on spermatozoa, with particular emphasis on mitochondrial function. From the extensive literature analyzed, we conclude that in some cases the role of sperm mitochondria as putative predictors of sperm functionality is very obvious, while in others further studies are needed to clarify this issue.
[Mh] Termos MeSH primário: Anticoncepcionais Masculinos/farmacologia
Mitocôndrias/efeitos dos fármacos
Espermatozoides/efeitos dos fármacos
[Mh] Termos MeSH secundário: Suplementos Nutricionais
Poluentes Ambientais/toxicidade
Seres Humanos
Masculino
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Mitocôndrias/metabolismo
Espécies Reativas de Oxigênio/metabolismo
Espermatozoides/fisiologia
Drogas Ilícitas/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Contraceptive Agents, Male); 0 (Environmental Pollutants); 0 (Reactive Oxygen Species); 0 (Street Drugs)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170208
[Lr] Data última revisão:
170208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160426
[St] Status:MEDLINE



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