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[PMID]: 29499665 [Au] Autor: Zhu Z; Zhang H; Yue J; Liu S; Li Z; Wang L [Ad] Endereço: People's Hospital of Zhengzhou University and Henan Provincial People's Hospital, Henan Eye Institute, Henan Eye Hospital, Zhengzhou, 450003, China. [Ti] Título: Antimicrobial efficacy of corneal cross-linking in vitro and in vivo for Fusarium solani: a potential new treatment for fungal keratitis. [So] Source: BMC Ophthalmol;18(1):65, 2018 Mar 02. [Is] ISSN: 1471-2415 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: Fungal keratitis is one of the major causes of visual impairment worldwide. However, the effectiveness of corneal collagen cross-linking (CXL) for fungal keratitis remains controversial. In this study, we developed an in vitro and an in vivo models to assess the efficacy of CXL for Fusarium keratitis. METHODS: The effect of in vitro CXL fungicidal was evaluated on the cultures of Fusarium solani which were exposed to irradiation for different durations. Viability of fungal was appraised under four conditions: no treatment (control); CXL: UVA (365 nm)/riboflavin; riboflavin and UVA (365 nm). Each batch of sterile plate culture was irradiated for different CXL durations. The in vivo Therapeutic effect was studied on a mouse keratitis model. The animals were divided randomly into three groups: group A with no treatment (control); Group B with CXL treatment for two minutes and group C with CXL treatment for three minutes. The CXL procedure was performed 24 h post inoculation in each group. All mice with corneal involvement were scored daily for 7 days and 10 days after infection. Corneals were extracted at various time points for quantitative fungal recovery. Histological evaluations were conducted to calculate the number of polymorphonuclear cells. RESULTS: Viability of fungal decreased significantly in CXL group with 30-min irradiation compared with that in control, riboflavin and UVA groups (P < 0.01). The colony-forming units (CFUs) of fungal solutions in culture significantly decreased with CXL treatment (P < 0.05). Clinical scores, corneal lesion, corneal opacity, neovascularization and the depth of ulceration scores in group B and group C were remarkably lower than that in group A (P < 0.05, P = 0.001, P = 0.001, P = 0.034 and P = 0.025 respectively). Scores of group C were much lower than that in group B. Histological revealed that destruction of corneal collagen fibers and infiltration of inflammatory cells into corneal tissue in group B and group C were much lower than that in group A. CONCLUSIONS: We believe that CXL treatment may be applied to fungal keratitis, therapeutic efficacy will improve with longer treatment duration. [Mh] Termos MeSH primário: Anti-Infecciosos/uso terapêutico Substância Própria/metabolismo Úlcera da Córnea/tratamento farmacológico Reagentes para Ligações Cruzadas Infecções Oculares Fúngicas/tratamento farmacológico Fusariose/tratamento farmacológico Fusarium/efeitos dos fármacos [Mh] Termos MeSH secundário: Animais Colágeno/metabolismo Contagem de Colônia Microbiana Úlcera da Córnea/metabolismo Úlcera da Córnea/microbiologia Modelos Animais de Doenças Infecções Oculares Fúngicas/metabolismo Infecções Oculares Fúngicas/microbiologia Fusariose/metabolismo Fusariose/microbiologia Fusarium/isolamento & purificação Masculino Camundongos Camundongos Endogâmicos C57BL Fármacos Fotossensibilizantes/uso terapêutico Riboflavina/uso terapêutico Raios Ultravioleta [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Infective Agents); 0 (Cross-Linking Reagents); 0 (Photosensitizing Agents); 9007-34-5 (Collagen); TLM2976OFR (Riboflavin) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180304 [St] Status: MEDLINE [do] DOI: 10.1186/s12886-018-0727-0

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[PMID]: 29175396 [Au] Autor: Wang F; Liu F; Chen W; Xu R; Wang W [Ad] Endereço: School of Biological Science, Luoyang Normal University, Luoyang, 471022, China; Cold Water Fish Breeding Engineering Technology Research Center of Henan Province, Luoyang, 471022, China. Electronic address: wangfan7677@163.com. [Ti] Título: Effects of triclosan (TCS) on hormonal balance and genes of hypothalamus-pituitary- gonad axis of juvenile male Yellow River carp (Cyprinus carpio). [So] Source: Chemosphere;193:695-701, 2018 Feb. [Is] ISSN: 1879-1298 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Triclosan (TCS) is a broad spectrum antimicrobial agent which has been widely dispersed and determinated in the aquatic environment. However, the effects of TCS on reproductive endocrine in male fish are poorly understood. In this study, male Yellow River carp (Cyprinus carpio) were exposed to 0, 1/5, 1/10 and 1/20 LC (96 h LC of TCS to carp) TCS under semi-static conditions for 42 d. Vitellogenin (Vtg), 17ß-estradiol (E ), testosterone(T), gonadotropin (GtH), and gonadotropin-releasing hormone (GnRH) levels were measured by enzyme-linked immunosorbent assay (ELISA). Meanwhile, we also examined the mRNA expressions of aromatase, GtHs-ß, GnRH, estrogen receptor (Er), and androgen receptor (Ar) by quantitative Real-time Polymerase Chain Reaction (qRT-PCR). TCS induced Vtg levels of hepatopancreas, E levels of serum, and inhibited Ar and Er mRNA levels, suggesting that the induction of Vtg production by TCS was indirectly caused by non-Er pathways. TCS-induced Vtg levels by interfering with the reproductive axis at plenty of latent loci of male carps: (a) TCS exposure increased the aromatase mRNA expression of hypothalamus and gonad aromatase, consequently increasing serum concentrations of E to induce Vtg in hepatopancreas; (b) TCS treatment changed GtH-ß and GnRH mRNA expression and secretion, causing the disturbance of reproductive endocrine; (c) TCS exposure decreased Ar mRNA levels, indicating potential Ar-mediated antiandrogen action. These mechanisms showed that TCS may induce Vtg production in male carp by non-Er-mediated pathways. [Mh] Termos MeSH primário: Carpas/metabolismo Triclosan/toxicidade Poluentes Químicos da Água/toxicidade [Mh] Termos MeSH secundário: Animais Anti-Infecciosos/toxicidade Aromatase/genética Sistema Endócrino/efeitos dos fármacos Ensaio de Imunoadsorção Enzimática Estradiol/análise Hormônio Liberador de Gonadotropina/análise Hormônio Liberador de Gonadotropina/genética Gônadas/enzimologia Gônadas/metabolismo Hepatopâncreas/metabolismo Hormônios/metabolismo Hipotálamo/metabolismo Masculino Hipófise/metabolismo RNA Mensageiro/análise Reação em Cadeia da Polimerase em Tempo Real Receptores Estrogênicos/genética Reprodução/efeitos dos fármacos Testosterona/análise Vitelogeninas/análise [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Infective Agents); 0 (Hormones); 0 (RNA, Messenger); 0 (Receptors, Estrogen); 0 (Vitellogenins); 0 (Water Pollutants, Chemical); 33515-09-2 (Gonadotropin-Releasing Hormone); 3XMK78S47O (Testosterone); 4NM5039Y5X (Triclosan); 4TI98Z838E (Estradiol); EC 1.14.14.1 (Aromatase); EC 1.14.14.1 (CYP19A1 protein, human) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171128 [St] Status: MEDLINE

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[PMID]: 28742057 [Au] Autor: Gonçalves MLL; Kalil Bussadori S; Dadalti Fragoso Y; da Silva VVB; Melo Deana A; da Mota ACC; Horácio Pinto E; Horliana ACR; Miranda França C [Ad] Endereço: Postgraduate Program on Biophotonics Applied to Health Sciences, Nove de Julho University, Vergueiro Street, 235/249, Liberdade, ZIP 01504-001, São Paulo, SP, Brazil. [Ti] Título: Effect of photodynamic therapy in the reduction of halitosis in patients with multiple sclerosis: clinical trial. [So] Source: J Breath Res;11(4):046006, 2017 Oct 27. [Is] ISSN: 1752-7163 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Smell and odours play a vital role in social interaction. Halitosis is a social problem that affects one third of the population, causing a negative impact on the quality of life. There is little knowledge on the prevalence and management of halitosis in multiple sclerosis (MS) patients. The present study aims to evaluate the presence of halitosis in patients with MS when compared to a control group, and also evaluate treatment of the problem with antimicrobial photodynamic therapy (aPDT). This is a case-control clinical study in which 60 patients were evaluated: 30 MS patients in treatment at the Specialties Clinic School of Medicine, and 30 healthy patients, matched in age and gender for the control group. Data was collected on the duration of the disease as well as the degree of disability and medication use in the MS group. For all patients, halitosis was assessed with Oral Chroma™. Individuals with halitosis underwent treatment with tongue scraping and aPDT. The photosensitizer was methylene blue (0.005%) and a THERAPY XT-EC laser (660 nm, 9 J, 100 mW for 90 s per point, 320 J cm , 3537 mW cm ) was used. Six points 1 cm apart from each other were irradiated in the tongue dorsum. There was a positive correlation between the disability and disease duration. No parameter was correlated with halitosis. Patients with MS have higher levels of SH compounds when compared to the control group (p = 0.003, Mann-Whitney), but after aPDT both groups significantly reduced the levels to under the halitosis threshold. The aPDT scraping treatment was effective in the immediate reduction of halitosis in both groups. [Mh] Termos MeSH primário: Halitose/complicações Halitose/tratamento farmacológico Esclerose Múltipla/complicações Fotoquimioterapia [Mh] Termos MeSH secundário: Adulto Idoso Anti-Infecciosos/uso terapêutico Testes Respiratórios Estudos de Casos e Controles Feminino Seres Humanos Masculino Azul de Metileno/uso terapêutico Meia-Idade Fármacos Fotossensibilizantes/uso terapêutico Qualidade de Vida Adulto Jovem [Pt] Tipo de publicação: CLINICAL TRIAL; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Infective Agents); 0 (Photosensitizing Agents); T42P99266K (Methylene Blue) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170726 [St] Status: MEDLINE [do] DOI: 10.1088/1752-7163/aa8209

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[PMID]: 28470277 [Au] Autor: Tseng TS; Tsai KC; Chen C [Ad] Endereço: Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan. bmchinp@ibms.sinica.edu.tw. [Ti] Título: Characterizing the structure-function relationship reveals the mode of action of a novel antimicrobial peptide, P1, from jumper ant Myrmecia pilosula. [So] Source: Mol Biosyst;13(6):1193-1201, 2017 Jun 01. [Is] ISSN: 1742-2051 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Microbial infections of antibiotic-resistant strains cause serious diseases and have a significant impact on public health worldwide, so novel antimicrobial drugs are urgently needed. Insect venoms, a rich source of bioactive components containing antimicrobial peptides (AMPs), are attractive candidates for new therapeutic agents against microbes. Recently, a novel peptide, P1, identified from the venom of the Australian jumper ant Myrmecia pilosula, showed potent antimicrobial activities against both Gram-negative and Gram-positive bacteria, but its structure-function relationship is unknown. Here, we used biochemical and biophysical techniques coupled with computational simulations to explore the mode of action of P1 interaction with dodecylphosphocholine (DPC) micelles as a model membrane system. Our circular dichroism (CD) and NMR studies revealed an amphipathic α-helical structure for P1 upon interaction with DPC micelles. A paramagnetic relaxation enhancement approach revealed that P1 orients its α-helix segment (F6-G14) into DPC micelles. In addition, the α-helix segment could be essential for membrane permeabilization and antimicrobial activity. Moreover, the arginine residues R8, R11, and R15 significantly contribute to helix formation and membrane-binding affinity. The lysine residue K19 of the C-terminus functionally guides P1 to interact with DPC micelles in the early interaction stage. Our study provides insights into the mode of action of P1, which is valuable in modifying and developing potent AMPs as antibiotic drugs. [Mh] Termos MeSH primário: Anti-Infecciosos/química Anti-Infecciosos/farmacologia Biologia Computacional [Mh] Termos MeSH secundário: Peptídeos Catiônicos Antimicrobianos/química Peptídeos Catiônicos Antimicrobianos/farmacologia Dicroísmo Circular Bactérias Gram-Negativas/efeitos dos fármacos Bactérias Gram-Positivas/efeitos dos fármacos Espectroscopia de Ressonância Magnética Micelas Testes de Sensibilidade Microbiana Estrutura Secundária de Proteína Relação Estrutura-Atividade [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Infective Agents); 0 (Antimicrobial Cationic Peptides); 0 (Micelles) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170505 [St] Status: MEDLINE [do] DOI: 10.1039/c6mb00810k

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[PMID]: 28450246 [Au] Autor: Günes S; Tihminlioglu F [Ad] Endereço: Graduate Program of Biogineering, Izmir Institute of Technology, Izmir, 35430, Turkey. [Ti] Título: Hypericum perforatum incorporated chitosan films as potential bioactive wound dressing material. [So] Source: Int J Biol Macromol;102:933-943, 2017 Sep. [Is] ISSN: 1879-0003 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Recent studies in wound dressing applications offer new therapies and promote wound healing process. The aim of this study was to develop Hypericum perforatum (St John's Wort) oil incorporated chitosan films for wound dressing applications. H. perforatum oil as a potential therapeutic agent was encapsulated in chitosan film to achieve a better wound dressing material. Oil incorporated chitosan films were successfully prepared by solvent casting method in different oil concentrations (0.25-1.5%v/v). Water vapor permeability (WVP), mechanical test, swelling behavior and surface hydrophobicity were performed in order to characterize the prepared films. Antimicrobial test was performed by disc diffusion method and the growth inhibition effects of the films including different amount of H. perforatum oil were investigated on Escherichia coli and Staphylococcus aureus. WVP increased with oil incorporation and the highest value was obtained for 0.25% oil concentration.The highest strain value was obtained in 0.25% oil content films although tensile stress decreased with increasing oil content. H. perforatum oil incorporated films had antimicrobial effect on both microorganisms. Chitosan based films had no cytotoxic effects on NIH3T3fibroblast cells and provided a good surface for cell attachment and proliferation. The results showed that the H. perforatum incorporated chitosan films seems to be a potential and novel biomaterial for wound healing applications. [Mh] Termos MeSH primário: Bandagens Materiais Biocompatíveis/química Materiais Biocompatíveis/farmacologia Quitosana/química Hypericum/química Óleos Vegetais/química Cicatrização [Mh] Termos MeSH secundário: Animais Anti-Infecciosos/química Anti-Infecciosos/farmacologia Bandagens/microbiologia Adesão Celular/efeitos dos fármacos Proliferação Celular/efeitos dos fármacos Sobrevivência Celular/efeitos dos fármacos Fenômenos Mecânicos Camundongos Células NIH 3T3 Permeabilidade Vapor [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Infective Agents); 0 (Biocompatible Materials); 0 (Plant Oils); 0 (Steam); 9012-76-4 (Chitosan) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170429 [St] Status: MEDLINE

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[PMID]: 29263292 [Au] Autor: Hyde RM; Remnant JG; Bradley AJ; Breen JE; Hudson CD; Davies PL; Clarke T; Critchell Y; Hylands M; Linton E; Wood E; Green MJ [Ad] Endereço: School of Veterinary Medicine and Science, University of Nottingham, Nottingham, UK. [Ti] Título: Quantitative analysis of antimicrobial use on British dairy farms. [So] Source: Vet Rec;181(25):683, 2017 12 23. [Is] ISSN: 2042-7670 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Antimicrobial resistance has been reported to represent a growing threat to both human and animal health, and concerns have been raised around levels of antimicrobial usage (AMU) within the livestock industry. To provide a benchmark for dairy cattle AMU and identify factors associated with high AMU, data from a convenience sample of 358 dairy farms were analysed using both mass-based and dose-based metrics following standard methodologies proposed by the European Surveillance of Veterinary Antimicrobial Consumption project. Metrics calculated were mass (mg) of antimicrobial active ingredient per population correction unit (mg/PCU), defined daily doses (DDDvet) and defined course doses (DCDvet). AMU on dairy farms ranged from 0.36 to 97.79 mg/PCU, with a median and mean of 15.97 and 20.62 mg/PCU, respectively. Dose-based analysis ranged from 0.05 to 20.29 DDDvet, with a median and mean of 4.03 and 4.60 DDDvet, respectively. Multivariable analysis highlighted that usage of antibiotics via oral and footbath routes increased the odds of a farm being in the top quartile (>27.9 mg/PCU) of antimicrobial users. While dairy cattle farm AMU appeared to be lower than UK livestock average, there were a selection of outlying farms with extremely high AMU, with the top 25 per cent of farms contributing greater than 50 per cent of AMU by mass. Identification of these high use farms may enable targeted AMU reduction strategies and facilitate a significant reduction in overall dairy cattle AMU. [Mh] Termos MeSH primário: Anti-Infecciosos/uso terapêutico Indústria de Laticínios Fazendas [Mh] Termos MeSH secundário: Animais Bovinos Seres Humanos Reino Unido [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Infective Agents) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171222 [St] Status: MEDLINE [do] DOI: 10.1136/vr.104614

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[PMID]: 29215338 [Au] Autor: Kart D; Kustimur AS; Sagiroglu M; Kalkanci A [Ad] Endereço: Department of Pharmaceutical Microbiology, Hacettepe University Faculty of Pharmacy, Ankara, Turkey. [Ti] Título: Evaluation of Antimicrobial Durability and Anti-Biofilm Effects in Urinary Catheters Against Clinical Isolates and Reference Strains. [So] Source: Balkan Med J;34(6):546-552, 2017 12 01. [Is] ISSN: 2146-3131 [Cp] País de publicação: Turkey [La] Idioma: eng [Ab] Resumo: BACKGROUND: and biofilms are major causes of catheter-associated urinary tract infections. Antimicrobial-coated or impregnated urinary catheters are seen as a possible way to prevent these infections. AIMS: To determine the biofilm-forming ability of 89 isolates from urinary tract infections and to compare several urinary catheters for antimicrobial durability and the inhibitory effects on biofilm formation of different laboratory strains and clinical isolates of . STUDY DESIGN: experimental study. METHODS: The biofilm forming ability of isolates was determined by the crystal violet staining and plate counting methods. For comparison of urinary catheters, biofilms of 45 isolates from the catheter samples of hospitalized patients and five laboratory strains of ATCC25922, ATCC35984, ATCC27853, ATCC29212 and ATCC90028 were formed on the catheters in 24-well tissue culture plates. Scanning electron microscopy analysis was performed to observe biofilms. RESULTS: All 89 isolates were found to be biofilm positive. Nitrofurazone-impregnated catheters significantly reduced the cell counts of isolates and completely inhibited the formation of and biofilms compared with the others. Regarding reduction of biofilm cell counts, a hydrophilic-coated catheter was more effective against , whereas a silver-coated catheter was found to be more effective against . The nitrofurazone-impregnated catheter had the best antimicrobial durability. CONCLUSION: Urine isolates of had considerable ability with respect to biofilm formation. The nitrofurazone-impregnated catheter was the most effective against all tested bacteria; however, the effect of a hydrophilic or silver-coated catheter depends on the species present in it. [Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia Biofilmes/efeitos dos fármacos Infecções Relacionadas a Cateter/microbiologia Cateteres de Demora/microbiologia Enterococcus faecalis/efeitos dos fármacos Nitrofurazona/farmacologia Infecções Urinárias/microbiologia [Mh] Termos MeSH secundário: Infecções Relacionadas a Cateter/prevenção & controle Materiais Revestidos Biocompatíveis Enterococcus faecalis/isolamento & purificação Seres Humanos Técnicas In Vitro Testes de Sensibilidade Microbiana Silicones Prata Cateterismo Urinário/efeitos adversos Infecções Urinárias/prevenção & controle [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Anti-Infective Agents); 0 (Coated Materials, Biocompatible); 0 (Silicones); 3M4G523W1G (Silver); X8XI70B5Z6 (Nitrofurazone) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171208 [St] Status: MEDLINE [do] DOI: 10.4274/balkanmedj.2016.1853

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[PMID]: 28459897 [Au] Autor: Graber CJ; Jones MM; Chou AF; Zhang Y; Goetz MB; Madaras-Kelly K; Samore MH; Glassman PA [Ad] Endereço: Infectious Diseases Section, VA Greater Los Angeles Healthcare System, Los Angeles, CA; David Geffen School of Medicine at the University of California, Los Angeles, CA. [Ti] Título: Association of Inpatient Antimicrobial Utilization Measures with Antimicrobial Stewardship Activities and Facility Characteristics of Veterans Affairs Medical Centers. [So] Source: J Hosp Med;12(5):301-309, 2017 May. [Is] ISSN: 1553-5606 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Antimicrobial stewardship programs (ASPs) have been advocated to improve antimicrobial utilization, but program implementation is variable. Antimicrobial stewardship programs (ASPs) have been advocated to improve antimicrobial utilization, but program implementation is variable. OBJECTIVE: To determine associations between ASPs and facility characteristics, and inpatient antimicrobial utilization measures in the Veterans Affairs (VA) system in 2012. DESIGN: In 2012, VA administered a survey on antimicrobial stewardship practices to designated ASP contacts at VA acute care hospitals. From the survey, we identified 34 variables across 3 domains (evidence, organizational context, and facilitation) that were assessed using multivariable least absolute shrinkage and selection operator regression against 4 antimicrobial utilization measures from 2012: aggregate acute care antimicrobial use, antimicrobial use in patients with non-infectious primary discharge diagnoses, missed opportunities to convert from parenteral to oral antimicrobial therapy, and double anaerobic coverage. SETTING: All 130 VA facilities with acute care services. RESULTS: Variables associated with at least 3 favorable changes in antimicrobial utilization included presence of postgraduate physician/pharmacy training programs, number of antimicrobial-specific order sets, frequency of systematic de-escalation review, presence of pharmacists and/or infectious diseases (ID) attendings on acute care ward teams, and formal ID training of the lead ASP pharmacist. Variables associated with 2 unfavorable measures included bed size, the level of engagement with VA Antimicrobial Stewardship Task Force online resources, and utilization of antimicrobial stop orders. CONCLUSIONS: Formalization of ASP processes and presence of pharmacy and ID expertise are associated with favorable utilization. Systematic de-escalation review and order set establishment may be high-yield interventions. Journal of Hospital Medicine 2017;12:301-309. [Mh] Termos MeSH primário: Anti-Infecciosos/uso terapêutico Gestão de Antimicrobianos/normas Revisão de Uso de Medicamentos/normas Hospitalização Hospitais de Veteranos/normas United States Department of Veterans Affairs/normas [Mh] Termos MeSH secundário: Gestão de Antimicrobianos/métodos Revisão de Uso de Medicamentos/métodos Hospitalização/tendências Seres Humanos Serviço de Farmácia Hospitalar/métodos Serviço de Farmácia Hospitalar/normas Inquéritos e Questionários Estados Unidos/epidemiologia Veteranos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Infective Agents) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170502 [St] Status: MEDLINE [do] DOI: 10.12788/jhm.2730

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[PMID]: 29318321 [Au] Autor: Ziaie M; Dilmaghani KA; Tukmechi A [Ti] Título: Synthesis and Biological Evaluation of 1,2,4-Triazoles and 1,3,4-Oxadiazoles Derivatives Linked to 1,4-Dihydropyridines Scaffold. [So] Source: Acta Chim Slov;64(4):895-901, 2017 Dec. [Is] ISSN: 1318-0207 [Cp] País de publicação: Slovenia [La] Idioma: eng [Ab] Resumo: A series of diethyl-2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate derivative coupled to 1,3,4-oxadiazole-5-thiones and 1,2,4-triazole-5-thiones moieties at C2,C6 positions of 1,4-dihydropyridine ring system was prepared. This linkage was carried out by the reaction of 1,3,4-oxadiazole-5-thiones and 1,2,4-triazole-5-thiones with 2,6-dibromomethyl-3,5-diethoxycarbonyl-4-phenyl-1,4-dihydropyridine in the presence of potassium carbonate as a weak base and dry acetone as the solvent. The newly synthesized compounds were characterized by FT-IR, 1H NMR, 13C NMR spectral data, elemental analysis and FAB-MS. The synthesized compounds were tested for their antimicrobial and antifungal activity against Escherichia coli and Aspergillus fumigatus in vitro in comparison with Enrofloxacin and Amphotericin as the reference drugs which are normally used for treating such infections. The synthetic compounds showed different inhibition zones against tested bacteria and fungi. Compound 8d showed more antagonistic activity against E. coli and A. fumigatus. [Mh] Termos MeSH primário: Anti-Infecciosos/síntese química Di-Hidropiridinas/química Oxidiazóis/química Triazóis/química [Mh] Termos MeSH secundário: Anti-Infecciosos/farmacologia Di-Hidropiridinas/farmacologia Espectroscopia de Ressonância Magnética Testes de Sensibilidade Microbiana Oxidiazóis/farmacologia Espectroscopia de Infravermelho com Transformada de Fourier Triazóis/farmacologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Infective Agents); 0 (Dihydropyridines); 0 (Oxadiazoles); 0 (Triazoles) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180306 [Lr] Data última revisão: 180306 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180111 [St] Status: MEDLINE

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[PMID]: 29318288 [Au] Autor: Beyzaei H; Motraghi Z; Aryan R; Zahedi MM; Samzadeh-Kermani A [Ti] Título: Green One-pot Synthesis of Novel Polysubstituted Pyrazole Derivatives as Potential Antimicrobial Agents. [So] Source: Acta Chim Slov;64(4):911-918, 2017 Dec. [Is] ISSN: 1318-0207 [Cp] País de publicação: Slovenia [La] Idioma: eng [Ab] Resumo: Various biological properties of natural and synthetic pyrazole derivatives such as anti-inflammatory, antimicrobial, neuroprotective, anticonvulsant, antidepressant and anticancer activities encouraged us to propose a new, fast, green and eco-friendly procedure for the preparation of some novel 5-amino-3-(aryl substituted)-1-(2,4-dinitrophenyl)-1H-pyrazole-4-carbonitriles. They were efficiently synthesized via one-pot two-step process reaction of malononitrile, 2,4-dinitrophenylhydrazine and different benzaldehydes in deep eutectic solvent (DES) glycerol/potassium carbonate. The products yield and reaction times were considerably improved in the presence of applied DES. Antibacterial effects of all newly synthesized pyrazoles in comparison with several common antibiotics were evaluated against a variety of Gram-positive and Gram-negative pathogenic bacteria. In addition to, their inhibitory activities on three fungi were compared to some current antifungal agents. The moderate to good antimicrobial potentials particularly against fungi were observed in the major heterocyclic compounds according to the IZD, MIC, MBC and MFC results. [Mh] Termos MeSH primário: Anti-Infecciosos/síntese química Pirazóis/síntese química [Mh] Termos MeSH secundário: Anti-Infecciosos/farmacologia Pirazóis/farmacologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Infective Agents); 0 (Pyrazoles) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180306 [Lr] Data última revisão: 180306 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180111 [St] Status: MEDLINE

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