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Pesquisa : D27.505.954.122.250.075.080 [Categoria DeCS]
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  1 / 2619 MEDLINE  
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[PMID]:29240417
[Au] Autor:Li B; Ren Y; Zhang DX; Xu S; Mu W; Liu F
[Ad] Endereço:Shandong Provincial Key Laboratory for Biology of Vegetable Diseases and Insect Pests, College of Plant Protection, Shandong Agricultural University , Tai'an, Shandong 271018, People's Republic of China.
[Ti] Título:Modifying the Formulation of Abamectin To Promote Its Efficacy on Southern Root-Knot Nematode (Meloidogyne incognita) under Blending-of-Soil and Root-Irrigation Conditions.
[So] Source:J Agric Food Chem;66(4):799-805, 2018 Jan 31.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The southern root-knot nematode (RKN), Meloidogyne incognita, is the most disastrous and prevalent nematode threat to the production of crops, especially vegetables. In the current study, second-stage juveniles (J2) of M. incognita were collected from five regions near Tai'an, China. The toxicity of abamectin to these J2 had insignificant differences, with LC values of approximately 2 mg/L. Two pesticide application approaches (i.e., blending-of-soil and root-irrigation) were adopted in pot experiments; blending-of-soil was more beneficial for promoting the efficacy of abamectin on the RKN of tomatoes. Abamectin microcapsule suspension exhibited superiority to emulsifiable concentrate (EC) at dosages of 5 and 10 mg active ingredient per plant integrating efficacy, root length, plant height, the fresh weight of roots, and the fresh weight of stems + leaves. Adsorption, leaching, and mobility of abamectin in the soil also verified bioactivity test results. Modifying the formulation of abamectin can promote its efficacy on RKN under different application approaches.
[Mh] Termos MeSH primário: Antinematódeos
Ivermectina/análogos & derivados
Doenças das Plantas/parasitologia
Raízes de Plantas/parasitologia
Tylenchoidea/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adsorção
Irrigação Agrícola/métodos
Animais
China
Produtos Agrícolas
Ivermectina/administração & dosagem
Ivermectina/química
Lycopersicon esculentum/parasitologia
Praguicidas
Solo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antinematodal Agents); 0 (Pesticides); 0 (Soil); 5U8924T11H (abamectin); 70288-86-7 (Ivermectin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04146


  2 / 2619 MEDLINE  
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[PMID]:29372633
[Ti] Título:Meeting of the International Task Force for Disease Eradication, October 2017.
[Ti] Título:Réunion du Groupe spécial international pour l'éradication des maladies, octobre 2017..
[So] Source:Wkly Epidemiol Rec;93(4-5):33-8, 2018 Jan 26.
[Is] ISSN:0049-8114
[Cp] País de publicação:Switzerland
[La] Idioma:eng; fre
[Mh] Termos MeSH primário: Erradicação de Doenças/organização & administração
Doenças do Cão/prevenção & controle
Dracunculíase/prevenção & controle
Dracunculíase/veterinária
[Mh] Termos MeSH secundário: Animais
Antinematódeos/uso terapêutico
Chade/epidemiologia
Surtos de Doenças/prevenção & controle
Surtos de Doenças/estatística & dados numéricos
Reservatórios de Doenças/parasitologia
Doenças do Cão/epidemiologia
Doenças do Cão/transmissão
Cães
Dracunculíase/epidemiologia
Dracunculíase/transmissão
Dracunculus/fisiologia
Etiópia/epidemiologia
Seres Humanos
Mali/epidemiologia
Sudão/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antinematodal Agents)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180127
[St] Status:MEDLINE


  3 / 2619 MEDLINE  
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[PMID]:29059195
[Au] Autor:Forrer A; Khieu V; Schär F; Hattendorf J; Marti H; Neumayr A; Char MC; Hatz C; Muth S; Odermatt P
[Ad] Endereço:Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.
[Ti] Título:Strongyloides stercoralis is associated with significant morbidity in rural Cambodia, including stunting in children.
[So] Source:PLoS Negl Trop Dis;11(10):e0005685, 2017 Oct.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Strongyloides stercoralis is a soil-transmitted nematode that can replicate within its host, leading to long-lasting and potentially fatal infections. It is ubiquitous and highly prevalent in Cambodia. The extent of morbidity associated with S. stercoralis infection is difficult to assess due to the broad spectrum of symptoms and, thus, remains uncertain. METHODOLOGY/PRINCIPAL FINDINGS: Clinical signs were compared among S. stercoralis infected vs. non-infected participants in a cross-sectional survey conducted in 2012 in eight villages of Northern Cambodia, and before and after treatment with a single oral dose of ivermectin (200µg/kg BW) among participants harboring S. stercoralis. Growth retardation among schoolchildren and adolescents was assessed using height-for-age and thinness using body mass index-for-age. S. stercoralis prevalence was 31.1% among 2,744 participants. Urticaria (55% vs. 47%, OR: 1.4, 95% CI: 1.1-1.6) and itching (52% vs. 48%, OR: 1.2, 95% CI: 1.0-1.4) were more frequently reported by infected participants. Gastrointestinal, dermatological, and respiratory symptoms were less prevalent in 103 mono-infected participants after treatment. Urticaria (66% vs. 11%, OR: 0.03, 95% CI: 0.01-0.1) and abdominal pain (81 vs. 27%, OR: 0.07, 95% CI: 0.02-0.2) mostly resolved by treatment. S. stercoralis infection was associated with stunting, with 2.5-fold higher odds in case of heavy infection. CONCLUSIONS/SIGNIFICANCE: The morbidity associated with S. stercoralis confirmed the importance of gastrointestinal and dermatological symptoms unrelated to parasite load, and long-term chronic effects when associated with malnutrition. The combination of high prevalence and morbidity calls for the integration of S. stercoralis into ongoing STH control measures in Cambodia.
[Mh] Termos MeSH primário: Transtornos do Crescimento/parasitologia
Strongyloides stercoralis/isolamento & purificação
Estrongiloidíase/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Animais
Antinematódeos/uso terapêutico
Camboja/epidemiologia
Criança
Estudos Transversais
Fezes/parasitologia
Feminino
Transtornos do Crescimento/epidemiologia
Seres Humanos
Ivermectina/uso terapêutico
Masculino
Morbidade
Prevalência
População Rural
Estrongiloidíase/tratamento farmacológico
Estrongiloidíase/parasitologia
Estrongiloidíase/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antinematodal Agents); 70288-86-7 (Ivermectin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171024
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005685


  4 / 2619 MEDLINE  
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[PMID]:28813646
[Au] Autor:Kim MO; Choe MH; Yoon YN; Ahn J; Yoo M; Jung KY; An S; Hwang SG; Oh JS; Kim JS
[Ad] Endereço:Division of Radiation Cancer Research, Korea Institute of Radiological and Medical Sciences, Seoul, South Korea; Molecular-Targeted Drug Research Center and Korea Institute for Skin and Clinical Sciences, Konkuk University, Seoul, South Korea.
[Ti] Título:Antihelminthic drug niclosamide inhibits CIP2A and reactivates tumor suppressor protein phosphatase 2A in non-small cell lung cancer cells.
[So] Source:Biochem Pharmacol;144:78-89, 2017 Nov 15.
[Is] ISSN:1873-2968
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Protein phosphatase 2A (PP2A) is a critical tumor suppressor complex responsible for the inactivation of various oncogenes. Recently, PP2A reactivation has emerged asan anticancer strategy. Cancerous inhibitor of protein phosphatase 2A (CIP2A), an endogenous inhibitor of PP2A, is upregulated in many cancer cells, including non-small cell lung cancer (NSCLC) cells. We demonstrated that the antihelminthic drug niclosamide inhibited the expression of CIP2A and reactivated the tumor suppressor PP2A in NSCLC cells. We performed a drug-repurposing screen and identified niclosamide asa CIP2A suppressor in NSCLC cells. Niclosamide inhibited cell proliferation, colony formation, and tumor sphere formation, and induced mitochondrial dysfunction through increased mitochondrial ROS production in NSCLC cells; however, these effects were rescued by CIP2A overexpression, which indicated that the antitumor activity of niclosamide was dependent on CIP2A. We found that niclosamide increased PP2A activity through CIP2A inhibition, which reduced the phosphorylation of several oncogenic proteins. Moreover, we found that a niclosamide analog inhibited CIP2A expression and increased PP2A activity in several types of NSCLC cells. Finally, we showed that other well-known PP2A activators, including forskolin and FTY720, did not inhibit CIP2A and that their activities were not dependent on CIP2A. Collectively, our data suggested that niclosamide effectively suppressed CIP2A expression and subsequently activated PP2A in NSCLC cells. This provided strong evidence for the potential use of niclosamide asa PP2A-activating drug in the clinical treatment of NSCLC.
[Mh] Termos MeSH primário: Anti-Helmínticos/farmacologia
Autoantígenos/metabolismo
Carcinoma Pulmonar de Células não Pequenas/metabolismo
Neoplasias Pulmonares/metabolismo
Proteínas de Membrana/metabolismo
Niclosamida/farmacologia
Proteína Fosfatase 2/metabolismo
[Mh] Termos MeSH secundário: Anti-Helmínticos/uso terapêutico
Antinematódeos/farmacologia
Antinematódeos/uso terapêutico
Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Sobrevivência Celular/fisiologia
Relação Dose-Resposta a Droga
Seres Humanos
Neoplasias Pulmonares/tratamento farmacológico
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Proteínas de Membrana/antagonistas & inibidores
Niclosamida/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Antinematodal Agents); 0 (Autoantigens); 0 (KIAA1524 protein, human); 0 (Membrane Proteins); 8KK8CQ2K8G (Niclosamide); EC 3.1.3.16 (Protein Phosphatase 2)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170817
[St] Status:MEDLINE


  5 / 2619 MEDLINE  
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[PMID]:28623231
[Au] Autor:Fortea E; Lemieux V; Potvin L; Chikwana V; Griffin S; Hey T; McCaskill D; Narva K; Tan SY; Xu X; Vachon V; Schwartz JL
[Ad] Endereço:From the Département de pharmacologie et physiologie and Groupe d'étude des protéines membranaires, Université de Montréal, Montreal, Québec H3C 3J7, Canada.
[Ti] Título:Cry6Aa1, a nematocidal and insecticidal toxin, forms pores in planar lipid bilayers at extremely low concentrations and without the need of proteolytic processing.
[So] Source:J Biol Chem;292(32):13122-13132, 2017 Aug 11.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cry6Aa1 is a ( ) toxin active against nematodes and corn rootworm insects. Its 3D molecular structure, which has been recently elucidated, is unique among those known for other toxins. Typical three-domain toxins permeabilize receptor-free planar lipid bilayers (PLBs) by forming pores at doses in the 1-50 µg/ml range. Solubilization and proteolytic activation are necessary steps for PLB permeabilization. In contrast to other toxins, Cry6Aa1 formed pores in receptor-free bilayers at doses as low as 200 pg/ml in a wide range of pH (5.5-9.5) and without the need of protease treatment. When Cry6Aa1 was preincubated with Western corn rootworm (WCRW) midgut juice or trypsin, 100 fg/ml of the toxin was sufficient to form pores in PLBs. The overall biophysical properties of the pores were similar for all three forms of the toxin (native, midgut juice- and trypsin-treated), with conductances ranging from 28 to 689 pS, except for their ionic selectivity, which was slightly cationic for the native and midgut juice-treated Cry6Aa1, whereas dual selectivity (to cations or anions) was observed for the pores formed by the trypsin-treated toxin. Enrichment of PLBs with WCRW midgut brush-border membrane material resulted in a 2000-fold reduction of the amount of native Cry6Aa1 required to form pores and affected the biophysical properties of both the native and trypsin-treated forms of the toxin. These results indicate that, although Cry6Aa1 forms pores, the molecular determinants of its mode of action are significantly different from those reported for other toxins.
[Mh] Termos MeSH primário: Antinematódeos/farmacologia
Bacillus thuringiensis/metabolismo
Proteínas de Bactérias/farmacologia
Endotoxinas/farmacologia
Proteínas Hemolisinas/farmacologia
Inseticidas/farmacologia
Bicamadas Lipídicas/química
[Mh] Termos MeSH secundário: Ativação Metabólica
Animais
Antinematódeos/química
Antinematódeos/metabolismo
Proteínas de Bactérias/genética
Proteínas de Bactérias/metabolismo
Coleópteros/efeitos dos fármacos
Coleópteros/enzimologia
Coleópteros/crescimento & desenvolvimento
Digestão
Endotoxinas/genética
Endotoxinas/metabolismo
Proteínas Hemolisinas/genética
Proteínas Hemolisinas/metabolismo
Concentração de Íons de Hidrogênio
Proteínas de Insetos/metabolismo
Inseticidas/química
Inseticidas/metabolismo
Cinética
Larva/efeitos dos fármacos
Larva/enzimologia
Larva/crescimento & desenvolvimento
Fusão de Membrana/efeitos dos fármacos
Microvilosidades/química
Microvilosidades/enzimologia
Peptídeo Hidrolases/metabolismo
Porosidade/efeitos dos fármacos
Proteólise
Proteínas Recombinantes/metabolismo
Proteínas Recombinantes/farmacologia
Solubilidade
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antinematodal Agents); 0 (Bacterial Proteins); 0 (Endotoxins); 0 (Hemolysin Proteins); 0 (Insect Proteins); 0 (Insecticides); 0 (Lipid Bilayers); 0 (Recombinant Proteins); 0 (insecticidal crystal protein, Bacillus Thuringiensis); EC 3.4.- (Peptide Hydrolases)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170618
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M116.765941


  6 / 2619 MEDLINE  
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[PMID]:28574237
[Au] Autor:Balicka-Ramisz A; Laurans L; Jurczyk P; Kwita E; Ramisz A
[Ad] Endereço:Department of Biotechnology of Animal Reproduction and Environment Hygiene, West Pomeranian University of Technology, ul. Judyma 6, 71-466 Szczecin, Poland
[Ti] Título:Gastrointestinal nematodes and the deworming of mouflon (Ovis aries musimon) from Goleniowska Forest in West Pomerania province, Poland
[So] Source:Ann Parasitol;63(1):27-32, 2017.
[Is] ISSN:2299-0631
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Ruminants often live in environments where the natural balance has been disturbed by humans. As a result, there is a transfer of parasitosis to domestic animals and sometimes humans. The aim of the study was to determine the annual species composition and level of gastrointestinal nematode infection of mouflon (Ovis aries musimon) from the half-open breeding colonizing areas of the Goleniowska Forest, and to assess the effectiveness of deworming. The course of the parasitic infection of mouflon depends largely on geoclimatic and breeding factors. These diseases are caused by more than 17 species of nematodes with varying degrees of pathogenicity. Due to the high degree of parasitic infections in deer, both in Poland and abroad, it is necessary to develop specific preventive programs using preparations with a broad spectrum of action.
[Mh] Termos MeSH primário: Gastroenteropatias/parasitologia
Infecções por Nematoides/veterinária
Doenças dos Ovinos/parasitologia
[Mh] Termos MeSH secundário: Animais
Animais Selvagens
Antinematódeos/administração & dosagem
Feminino
Gastroenteropatias/tratamento farmacológico
Gastroenteropatias/epidemiologia
Masculino
Nematoides
Infecções por Nematoides/tratamento farmacológico
Infecções por Nematoides/epidemiologia
Infecções por Nematoides/parasitologia
Polônia/epidemiologia
Ovinos
Doenças dos Ovinos/tratamento farmacológico
Doenças dos Ovinos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antinematodal Agents)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170706
[Lr] Data última revisão:
170706
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.17420/ap6301.81


  7 / 2619 MEDLINE  
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[PMID]:28558828
[Au] Autor:Hamel D; Bosco A; Rinaldi L; Cringoli G; Kaulfuß KH; Kellermann M; Fischer J; Wang H; Kley K; Mayr S; Rauh R; Visser M; Wiefel T; Fankhauser B; Rehbein S
[Ad] Endereço:Merial GmbH, Kathrinenhof Research Center, Walchenseestr. 8-12, 83101, Rohrdorf, Germany. dietmar.hamel@merial.com.
[Ti] Título:Eprinomectin pour-on (EPRINEX® Pour-on, Merial): efficacy against gastrointestinal and pulmonary nematodes and pharmacokinetics in sheep.
[So] Source:BMC Vet Res;13(1):148, 2017 May 30.
[Is] ISSN:1746-6148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The anthelmintic efficacy of the 0.5% w/v topical formulation of eprinomectin (EPN), EPRINEX® Pour-on (Merial) when administered at 1 mg/kg body weight was evaluated in sheep in two dose confirmation laboratory studies and one multicenter field study. In addition, the pharmacokinetics of EPN when administered at that dosage to adult sheep was determined. RESULTS: In the two dose confirmation studies, which included 10 sheep each, sheep treated with topical EPN had significantly (p < 0.05) fewer of the following nematodes than the untreated sheep with overall reduction of nematode counts by >99%: adult Dictyocaulus filaria, Haemonchus contortus, Teladorsagia circumcincta(pinnata/trifurcata), Trichostrongylus axei, T. colubriformis, T. vitrinus, Cooperia curticei, Nematodirus battus, Strongyloides papillosus, Chabertia ovina and Oesophagostomum venulosum, and inhibited fourth-stage Teladorsagia larvae. A total of 196 sheep harboring naturally acquired gastrointestinal nematode infections were included in the field efficacy study at two sites each in Germany (48 Merino x Ile de France lambs, 52 adult Merino females) and in Italy (adult male and female Bagnolese, Lacaune, Lacaune x Bagnolese, Bagnolese x Sarda sheep; 48 animals per site). Animals were blocked on pre-treatment body weight and within each block, one animal was randomly assigned to the control (untreated) group and three animals were randomly assigned to be treated with topical EPN. Examination of feces 14 days after treatment demonstrated that, relative to the controls, topical EPN-treated sheep had significantly (p < 0.0001) lower strongylid egg counts. Reduction was ≥97% at each site and 98.6% across all sites. Pharmacokinetics of EPN following single treatment with topical EPN were determined in eight ~4.5 year old female Merino cross sheep based on the analysis of plasma samples which were collected from two hours to 21 days following treatment. The main pharmacokinetic parameters were: C 6.20 ± 1.71 ng/mL, AUC 48.8 ± 19.2 day*ng/mL, T 3.13 ± 2.99 days and T 6.40 ± 2.95 days. No treatment-related health problems or adverse drug events were observed in any study. CONCLUSION: These studies demonstrated 0.5% w/v EPN administered topically at 1 mg/kg body weight to be highly efficacious against a broad range of ovine gastrointestinal nematodes and D. filaria lungworms and well tolerated by sheep of different ages, breeds, gender and physiological status.
[Mh] Termos MeSH primário: Antinematódeos/uso terapêutico
Gastroenteropatias/veterinária
Ivermectina/análogos & derivados
Pneumopatias Parasitárias/veterinária
Infecções por Nematoides/veterinária
Doenças dos Ovinos/parasitologia
[Mh] Termos MeSH secundário: Animais
Antinematódeos/farmacocinética
Feminino
Gastroenteropatias/parasitologia
Helmintíase Animal/tratamento farmacológico
Ivermectina/farmacocinética
Ivermectina/uso terapêutico
Pneumopatias Parasitárias/tratamento farmacológico
Masculino
Infecções por Nematoides/tratamento farmacológico
Ovinos
Doenças dos Ovinos/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Antinematodal Agents); 70288-86-7 (Ivermectin); 75KP30FD8O (eprinomectin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE
[do] DOI:10.1186/s12917-017-1075-7


  8 / 2619 MEDLINE  
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[PMID]:28475838
[Au] Autor:Song TY; Xu ZF; Chen YH; Ding QY; Sun YR; Miao Y; Zhang KQ; Niu XM
[Ad] Endereço:State Key Laboratory for Conservation and Utilization of Bio-Resources and Key Laboratory for Microbial Resources of the Ministry of Education, School of Life Science, Yunnan University , Kunming, Yunnan 650091, People's Republic of China.
[Ti] Título:Potent Nematicidal Activity and New Hybrid Metabolite Production by Disruption of a Cytochrome P450 Gene Involved in the Biosynthesis of Morphological Regulatory Arthrosporols in Nematode-Trapping Fungus Arthrobotrys oligospora.
[So] Source:J Agric Food Chem;65(20):4111-4120, 2017 May 24.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Types of polyketide synthase-terpenoid synthase (PKS-TPS) hybrid metabolites, including arthrosporols with significant morphological regulatory activity, have been elucidated from nematode-trapping fungus Arthrobotrys oligospora. A previous study suggested that the gene cluster AOL_s00215 in A. oligospora was involved in the production of arthrosporols. Here, we report that disruption of one cytochrome P450 monooxygenase gene AOL_s00215g280 in the cluster resulted in significant phenotypic difference and much aerial hyphae. A further bioassay indicated that the mutant showed a dramatic decrease in the conidial formation but developed numerous traps and killed 85% nematodes within 6 h in contact with prey, in sharp contrast to the wild-type strain with no obvious response. Chemical investigation revealed huge accumulation of three new PKS-TPS epoxycyclohexone derivatives with different oxygenated patterns around the epoxycyclohexone moiety and the absence of arthrosporols in the cultural broth of the mutant ΔAOL_s00215g280. These findings suggested that a study on the biosynthetic pathway for morphological regulatory metabolites in nematode-trapping fungus would provide an efficient way to develop new fungal biocontrol agents.
[Mh] Termos MeSH primário: Antinematódeos/metabolismo
Ascomicetos/enzimologia
Sistema Enzimático do Citocromo P-450/metabolismo
Proteínas Fúngicas/metabolismo
Nematoides/microbiologia
[Mh] Termos MeSH secundário: Animais
Antinematódeos/química
Ascomicetos/genética
Ascomicetos/crescimento & desenvolvimento
Ascomicetos/metabolismo
Vias Biossintéticas
Sistema Enzimático do Citocromo P-450/genética
Mutação
Nematoides/crescimento & desenvolvimento
Controle Biológico de Vetores
Policetídeo Sintases/genética
Policetídeo Sintases/metabolismo
Esporos Fúngicos/enzimologia
Esporos Fúngicos/genética
Esporos Fúngicos/crescimento & desenvolvimento
Esporos Fúngicos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antinematodal Agents); 0 (Fungal Proteins); 79956-01-7 (Polyketide Synthases); 9035-51-2 (Cytochrome P-450 Enzyme System)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170506
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b01290


  9 / 2619 MEDLINE  
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[PMID]:28434762
[Au] Autor:Chang Y; Zhang J; Chen X; Li Z; Xu X
[Ad] Endereço:Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
[Ti] Título:Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one derivatives containing thiourea and acylthiourea against Meloidogyne incognita.
[So] Source:Bioorg Med Chem Lett;27(11):2641-2644, 2017 06 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two series of novel 1,2,3-benzotriazin-4-one derivatives containing thiourea and acylthiourea were designed and synthesized. The bioassay results showed that most of the test compounds showed good nematicidal activity against M. incognita at the concentration of 10.0mgL in vivo. The compounds A13, A17 and B3 showed excellent nematicidal activity on the second stage juveniles of the root-knot nematode with the inhibition rate of 51.3%, 58.3% and 51.3% at the concentration of 1.0mgL respectively. It suggested that the structure of 1,2,3-benzotriazin-4-one derivatives containing thiourea and acylthiourea could be optimized further.
[Mh] Termos MeSH primário: Antinematódeos/síntese química
Tioureia/química
Triazinas/química
[Mh] Termos MeSH secundário: Animais
Antinematódeos/química
Antinematódeos/farmacologia
Desenho de Drogas
Doenças das Plantas/parasitologia
Relação Estrutura-Atividade
Triazinas/síntese química
Triazinas/farmacologia
Tylenchoidea/efeitos dos fármacos
Tylenchoidea/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antinematodal Agents); 0 (Triazines); 90-16-4 (1,2,3-benzotriazin-4-one); GYV9AM2QAG (Thiourea)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171124
[Lr] Data última revisão:
171124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170425
[St] Status:MEDLINE


  10 / 2619 MEDLINE  
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[PMID]:28398744
[Au] Autor:McMullin DR; Green BD; Prince NC; Tanney JB; Miller JD
[Ad] Endereço:Ottawa Carleton Institute of Chemistry, Carleton University , 1125 Colonel By Drive, Ottawa, Ontario, Canada , K1S 5B6.
[Ti] Título:Natural Products of Picea Endophytes from the Acadian Forest.
[So] Source:J Nat Prod;80(5):1475-1483, 2017 May 26.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Endophytes of healthy needles were collected from Picea rubens (red spruce) and P. mariana (black spruce) in a survey of southeastern New Brunswick, Canada. Four endophyte strains were selected for further investigation based on the production of biologically active extracts from culture filtrates during screening as well as phylogenetic relationship to species known to produce natural products or taxonomic novelty. A novel endophyte within the family Rhytismataceae produced two new dihydropyrones (1 and 2) as major metabolites together with phthalides (3 and 4), isocoumarins (5 and 6), and tyrosol (7). Lachnum cf. pygmaeum synthesized a new chlorinated para-quinone, chloromycorrhizinone A (8), and the nematicidal compounds (1'Z)-dechloromycorrhizin A (9), mycorrhizin A (10), and chloromycorrhizin A (11). A new isocoumarin (12) and four related structures (13-16) were isolated from an undescribed taxon in the Mycosphaerellaceae. The known antifungal metabolites cryptosporiopsin (17), 5-hydroxycryptosporiopsin (18), (+)-cryptosporiopsinol (19), and mellein (20) were produced by Pezicula sporulosa. Phylogenetically diverse conifer endophytes from the Acadian forest continue to be a productive source of new biologically active natural products.
[Mh] Termos MeSH primário: Antifúngicos/isolamento & purificação
Antifúngicos/farmacologia
Antinematódeos/isolamento & purificação
Antinematódeos/farmacologia
Produtos Biológicos/isolamento & purificação
Produtos Biológicos/farmacologia
Endófitos/química
Isocumarinas/isolamento & purificação
Isocumarinas/farmacologia
Picea/química
Pironas/isolamento & purificação
Pironas/farmacologia
Quinonas/isolamento & purificação
Quinonas/farmacologia
[Mh] Termos MeSH secundário: Antifúngicos/química
Antinematódeos/química
Ascomicetos/química
Ascomicetos/classificação
Produtos Biológicos/química
Canadá
Florestas
Isocumarinas/química
Estrutura Molecular
Filogenia
Pironas/química
Quinonas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Antinematodal Agents); 0 (Biological Products); 0 (Isocoumarins); 0 (Pyrones); 0 (Quinones)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b01157



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