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Pesquisa : D27.505.954.122.250.075.100.040 [Categoria DeCS]
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[PMID]:29190292
[Au] Autor:Mahanty S; Orrego MA; Cangalaya C; Adrianzen MP; Arroyo G; Calcina J; Gonzalez AE; García HH; Guerra-Giraldez C; Nash TE; Cysticercosis Working Group in Peru
[Ad] Endereço:Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
[Ti] Título:TNF-α blockade suppresses pericystic inflammation following anthelmintic treatment in porcine neurocysticercosis.
[So] Source:PLoS Negl Trop Dis;11(11):e0006059, 2017 Nov.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Neurocysticercosis (NCC) is an infection of the brain with the larval cyst of the tapeworm, Taenia solium. Cysticidal treatment induces parasite killing resulting in a post inflammatory response and seizures, which generally requires corticosteroid treatment to control inflammation. The nature of this response and how to best control it is unclear. We investigated the anti-inflammatory effects of pretreatment with etanercept (ETN), an anti-tumor necrosis factor agent, or dexamethasone (DEX), a high potency corticosteroid, on the post treatment inflammatory response in naturally infected pigs with neurocysticercosis after a single dose of the cysticidal drug praziquantel (PZQ). METHODOLOGY/PRINCIPAL FINDINGS: We followed the methods from a previously developed treatment model of NCC in naturally infected swine. The four study groups of infected pigs included 3 groups treated with PZQ on day 0: PZQ-treated alone (100 mg/kg PO; n = 9), pretreated with dexamethasone (DEX, 0.2 mg/kg IM administered on days -1, +1 and +3; n = 6), and pretreated with etanercept (ETN, 25 mg IM per animal on days -7 and 0; n = 6). The fourth group remained untreated (n = 3). As measured by quantitative RT-PCR, ETN pretreatment depressed transcription of a wide range of proinflammatory, regulatory and matrix protease encoding genes at 120 hr post PZQ treatment in capsules of cysts that demonstrated extravasated Evans Blue (EB) (a measure of blood brain barrier dysfunction) compared to animals not receiving ETN. Transcription was significantly depressed for the proinflammatory genes tumor necrosis factor (TNF)-α, and interferon (IFN)-γ; the inflammation regulating genes cytotoxic T-lymphocyte-associated protein (CTLA)4, interleukin (IL)-13 and transforming growth factor (TGF)-ß; the tissue remodeling genes matrix metalloprotease (MMP)1 and 9, tissue inhibitors of metalloproteases (TIMP)1 and 2, and the genes regulating endothelial function vascular endothelial growth factor (VEGF)1, angiopoietin (Ang)1, Ang 2, and platelet endothelial cell adhesion molecule (PECAM)-1. In contrast, transcription was only modestly decreased in the DEX pretreated pigs compared to PZQ alone, and only for TNF-α, IL-6, IFN-γ, TGF-ß and Ang1. IL-10 was not affected by either ETN or DEX pretreatments. The degree of inflammation, assessed by semi-quantitative inflammatory scores, was modestly decreased in both ETN and DEX pretreated animals compared to PZQ treated pigs whereas cyst damage scores were moderately decreased only in cysts from DEX pretreated pigs. However, the proportion of cysts with EB extravasation was not significantly changed in ETN and DEX pretreated groups. CONCLUSIONS/SIGNIFICANCE: Overall, TNF-α blockade using ETN treatment modulated expression of a large variety of genes that play a role in induction and control of inflammation and structural changes. In contrast the number of inflammatory cells was only moderately decreased suggesting weaker effects on cell migration into the inflammatory capsules surrounding cysts than on release of modulatory molecules. Taken together, these data suggest that TNF-α blockade may provide a viable strategy to manage post-treatment pericystic inflammation that follows antiparasitic therapy for neurocysticercosis.
[Mh] Termos MeSH primário: Etanercepte/administração & dosagem
Imunossupressores/administração & dosagem
Inflamação/prevenção & controle
Neurocisticercose/veterinária
Doenças dos Suínos/tratamento farmacológico
Fator de Necrose Tumoral alfa/antagonistas & inibidores
[Mh] Termos MeSH secundário: Animais
Anticestoides/uso terapêutico
Antiparasitários/efeitos adversos
Antiparasitários/uso terapêutico
Barreira Hematoencefálica/efeitos dos fármacos
Encéfalo/parasitologia
Citocinas/genética
Citocinas/imunologia
Dexametasona/administração & dosagem
Dexametasona/efeitos adversos
Etanercepte/efeitos adversos
Imunossupressores/efeitos adversos
Interferon gama/genética
Interferon gama/imunologia
Neurocisticercose/complicações
Neurocisticercose/tratamento farmacológico
Neurocisticercose/imunologia
Praziquantel/administração & dosagem
Praziquantel/efeitos adversos
Praziquantel/uso terapêutico
Suínos
Doenças dos Suínos/imunologia
Taenia solium/efeitos dos fármacos
Fator de Necrose Tumoral alfa/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticestodal Agents); 0 (Antiparasitic Agents); 0 (Cytokines); 0 (Immunosuppressive Agents); 0 (Tumor Necrosis Factor-alpha); 6490C9U457 (Praziquantel); 7S5I7G3JQL (Dexamethasone); 82115-62-6 (Interferon-gamma); OP401G7OJC (Etanercept)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0006059


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[PMID]:28867437
[Au] Autor:Huang CH; Lee YC; Chen YJ; Wang LJ; Shi YJ; Chang LS
[Ad] Endereço:Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.
[Ti] Título:Quinacrine induces the apoptosis of human leukemia U937 cells through FOXP3/miR-183/ß-TrCP/SP1 axis-mediated BAX upregulation.
[So] Source:Toxicol Appl Pharmacol;334:35-46, 2017 Nov 01.
[Is] ISSN:1096-0333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Quinacrine, which is clinically used as an antimalarial drug, has anti-cancer activity. However, mechanism underlying its cytotoxic effect remains to be completely elucidated. In the present study, we investigated the cytotoxic effect of quinacrine on human leukemia U937 cells. Quinacrine-induced apoptosis of U937 cells was accompanied with ROS generation, mitochondrial depolarization, and BAX upregulation. Quinacrine-treated U937 cells showed ROS-mediated p38 MAPK activation and ERK inactivation, which in turn upregulated FOXP3 transcription. FOXP3-mediated miR-183 expression decreased ß-TrCP mRNA stability and suppressed ß-TrCP-mediated SP1 degradation, thus increasing SP1 expression in U937 cells. Upregulated SP1 expression further increased BAX expression. BAX knock-down attenuated quinacrine-induced mitochondrial depolarization and increased the viability of quinacrine-treated cells. Together, our data indicate that quinacrine-induced apoptosis of U937 cells is mediated by mitochondrial alterations triggered by FOXP3/miR-183/ß-TrCP/SP1 axis-mediated BAX upregulation.
[Mh] Termos MeSH primário: Fatores de Transcrição Forkhead/metabolismo
MicroRNAs/metabolismo
Quinacrina/toxicidade
Fator de Transcrição Sp1/metabolismo
Proteína X Associada a bcl-2/metabolismo
Proteínas Contendo Repetições de beta-Transducina/metabolismo
[Mh] Termos MeSH secundário: Anticestoides/toxicidade
Apoptose/efeitos dos fármacos
Fatores de Transcrição Forkhead/genética
Regulação da Expressão Gênica/fisiologia
Técnicas de Silenciamento de Genes
Seres Humanos
Leucemia
MicroRNAs/genética
Fator de Transcrição Sp1/genética
Células U937
Proteína X Associada a bcl-2/genética
Proteínas Contendo Repetições de beta-Transducina/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticestodal Agents); 0 (BAX protein, human); 0 (FOXP3 protein, human); 0 (Forkhead Transcription Factors); 0 (MIRN183 microRNA, human); 0 (MicroRNAs); 0 (Sp1 Transcription Factor); 0 (Sp1 protein, human); 0 (bcl-2-Associated X Protein); 0 (beta-Transducin Repeat-Containing Proteins); H0C805XYDE (Quinacrine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170905
[St] Status:MEDLINE


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[PMID]:28763819
[Au] Autor:Stojkovic M; Hoffmann H; Mehrabi A; Sauer P; Weber T; Junghanss T
[Ad] Endereço:Sektion Klinische Tropenmedizin, Zentrum für Infektiologie, Universitätsklinikum Heidelberg.
[Ti] Título:[Diagnosis and Treatment of Echinococcal Diseases].
[Ti] Título:Diagnose und Therapie der Echinokokkosen..
[So] Source:Dtsch Med Wochenschr;142(15):1111-1116, 2017 Aug.
[Is] ISSN:1439-4413
[Cp] País de publicação:Germany
[La] Idioma:ger
[Mh] Termos MeSH primário: Equinococose
[Mh] Termos MeSH secundário: Anticestoides/uso terapêutico
Equinococose/diagnóstico
Equinococose/terapia
Alemanha
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticestodal Agents)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170802
[St] Status:MEDLINE
[do] DOI:10.1055/s-0043-109033


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[PMID]:28060040
[Au] Autor:Singhi P; Suthar R; Deo B; Malhi P; Khandelwal NK
[Ad] Endereço:From the *Department of Pediatrics, †Unit of Pediatric Neurology and Neurodevelopment, Department of Pediatrics, and ‡Department of radio diagnosis and imaging, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
[Ti] Título:Long-term Clinical and Radiologic Outcome in 500 Children With Parenchymal Neurocysticercosis.
[So] Source:Pediatr Infect Dis J;36(6):549-555, 2017 Jun.
[Is] ISSN:1532-0987
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Our aim was to study long-term clinical and radiologic outcome in children with parenchymal neurocysticercosis (NCC) and its predictors. METHOD: Five hundred children with NCC registered in the pediatric NCC clinic between January 1996 and December 2002 and followed till December 2009 were enrolled. Demographic details, clinical presentations and therapy received were recorded. Outcome was evaluated in terms of seizure recurrence and resolution of lesions on neuroimaging. Various factors that could influence outcome were studied. RESULTS: Mean age at presentation was 8 ± 2.7 years, and the mean duration of follow-up was 8.8 ± 2.03 years; 79.6% (398) had single lesion, and 20.4% (102) had multiple lesions at presentation; 14.5% (58) of children with single lesion, and 28.4% (29) of children with multiple lesions had recurrent seizures (P < 0.001) during follow-up. At 6-month follow-up neuroimaging, resolution was seen in 52.7% (210) and 31.3% (32) of children with single and multiple lesions, respectively (P < 0.001). On prolonged follow-up, 94.6% (384) of single-lesion NCC and 88% (90) of multiple-lesion NCC (P < 0.001) had radiologic resolution. Single-lesion NCC, radiologic resolution and cysticidal therapy were associated with better seizure outcome (P < 0.05). Children with multiple lesions had significantly higher percentage of calcified lesions on long-term follow-up compared with those with a single lesion (11.7% vs. 3.6%, P < 0.05). CONCLUSIONS: Children with a single-lesion NCC have favorable outcome with resolution of most of the lesions and few seizure recurrences. Cysticidal therapy leads to better seizure control and increased resolution of lesions on short-term follow-up.
[Mh] Termos MeSH primário: Convulsões/etiologia
[Mh] Termos MeSH secundário: Adolescente
Albendazol/uso terapêutico
Anticestoides/uso terapêutico
Criança
Pré-Escolar
Feminino
Seguimentos
Seres Humanos
Lactente
Estimativa de Kaplan-Meier
Masculino
Neurocisticercose/complicações
Neurocisticercose/diagnóstico por imagem
Neurocisticercose/tratamento farmacológico
Neurocisticercose/epidemiologia
Estudos Prospectivos
Convulsões/epidemiologia
Tomografia Computadorizada por Raios X
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticestodal Agents); F4216019LN (Albendazole)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170620
[Lr] Data última revisão:
170620
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170107
[St] Status:MEDLINE
[do] DOI:10.1097/INF.0000000000001536


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[PMID]:27884580
[Au] Autor:Fraga CM; da Costa TL; de Castro AM; Reynoso-Ducoing O; Ambrosio J; Hernández-Campos A; Castillo R; Vinaud MC
[Ad] Endereço:Laboratory of Studies of the Host-parasite Relationship, Tropical Pathology and Public Health Institute, Federal University of Goias, Brazil. Electronic address: carolinamfraga@gmail.com.
[Ti] Título:A benzimidazole derivative (RCB20) in vitro induces an activation of energetic pathways on Taenia crassiceps (ORF strain) cysticerci.
[So] Source:Exp Parasitol;172:12-17, 2017 Jan.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Human cysticercosis caused by Taenia crassiceps is unusual; however, it is an useful experimental model for cysticercosis studies. Benzimidazole derivatives are important antihelminthic drugs widely used against helminths. A novel compound 6-chloro-5-(1-naphthyloxy) -2-(trifluoromethyl)-1H-benzimidazole (RCB20) is a benzimidazole derivative less polar and more lipophilic. The aim of this study was to detect the effect of the RCB20 on the in vitro energetic metabolism of T. crassiceps cysticerci. For this, products of the metabolism both produced and secreted/excreted (S/E) by the parasite were detected through spectrophotometry and high performance liquid chromatography after exposure to 6.5 and 13 µM of RCB20 and albendazole sulfoxide (ABZSO). There was a gradual increase in the concentrations of glucose not uptaken by parasites exposed to both concentrations RCB20 and ABZSO. There was a higher concentration of all the organic acids related to the tricarboxilic acid cycle int the parasites exposed to RCB20. The structural differences between RCB20 and ABZSO result in different targets within the parasite and in a greater induction of the energetic pathways, such as the glycolysis and the TCA cycle. RCB20 is a good candidate as a substitute for anthelminthic benzimidazoles due to a differentiated site of action with similar outcome.
[Mh] Termos MeSH primário: Albendazol/análogos & derivados
Anticestoides/farmacologia
Benzimidazóis/farmacologia
Ciclo do Ácido Cítrico/efeitos dos fármacos
Cysticercus/efeitos dos fármacos
Cysticercus/metabolismo
Metabolismo Energético/efeitos dos fármacos
[Mh] Termos MeSH secundário: Albendazol/farmacologia
Animais
Glucose/metabolismo
Glicólise/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (6-chloro-5-(1-naphthyloxy)-2-(trifluoromethyl)-1H-benzimidazole); 0 (Anticestodal Agents); 0 (Benzimidazoles); F4216019LN (Albendazole); IY9XDZ35W2 (Glucose); J39B52TV34 (albendazole sulfoxide)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170206
[Lr] Data última revisão:
170206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161126
[St] Status:MEDLINE


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[PMID]:27880878
[Au] Autor:Gripper LB; Welburn SC
[Ad] Endereço:Division of Infection and Pathway Medicine, Edinburgh Infectious Diseases, Edinburgh Medical School, Biomedical Sciences, The University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK.
[Ti] Título:Neurocysticercosis infection and disease-A review.
[So] Source:Acta Trop;166:218-224, 2017 Feb.
[Is] ISSN:1873-6254
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Neurocysticercosis (NCC) is the most common parasitic disease of the human central nervous system (CNS), a pleomorphic disease with a diverse array of clinical manifestations. The infection is pleomorphic and dependent on a complex range of interconnecting factors, including number and size of the cysticerci, their stage of development and localisation within the brain with resulting difficulties in accurate diagnosis and staging of the disease. This review examines the factors that contribute to the accurate assessment of NCC distribution and transmission that are critical to achieving robust disease burden calculations. Control and prevention of T. solium transmission should be a key priority in global health as intervention can reduce the substantial healthcare and economic burdens inflicted by both NCC and taeniasis. Surveillance systems need to be better established, including implementing obligatory notification of cases. In the absence of reliable estimates of its global burden, NCC will remain-along with other endemic zoonoses, of low priority in the eyes of funding agencies-a truly neglected disease.
[Mh] Termos MeSH primário: Sistema Nervoso Central/parasitologia
Cysticercus
Doenças Negligenciadas/diagnóstico
Neurocisticercose/diagnóstico
Taenia solium/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Anticestoides/uso terapêutico
Anticonvulsivantes/uso terapêutico
Glucocorticoides/uso terapêutico
Seres Humanos
Doenças Negligenciadas/tratamento farmacológico
Doenças Negligenciadas/cirurgia
Neurocisticercose/tratamento farmacológico
Neurocisticercose/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anticestodal Agents); 0 (Anticonvulsants); 0 (Glucocorticoids)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161124
[St] Status:MEDLINE


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[PMID]:27595160
[Au] Autor:Nandi S; Ukil B; Roy S; Kundu S; Lyndem LM
[Ad] Endereço:a Department of Zoology , VisvaBharati University , Santiniketan , West Bengal , India.
[Ti] Título:Anthelmintic efficacy of Clerodendrum viscosum on fowl tapeworm Raillietina tetragona.
[So] Source:Pharm Biol;55(1):1401-1406, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Clerodendrum viscosum Vent. (Verbenaceae) is a shrub, widely used amongst the natives of India against various diseases. OBJECTIVE: Crude extract of the plant was tested in vitro on a tapeworm Raillietina tetragona Molin (Davaineidae) to evaluate its potential anthelmintic efficacy and ultrastructural changes in the parasite. MATERIALS AND METHODS: Parasites were exposed to different concentrations of ethanolic leaf extract (10-80 mg/mL) and praziquantel (0.0005-0.005 mg/mL) and incubated in phosphate-buffered saline (PBS). The pH was 7.4 at 37 °C, while one set of worms was incubated only with PBS as a control. Permanent immobilization of worms was determined visually when no motility occurred on physically disturbing them. The parasites exposed to high concentrations of leaf extract and praziquantel treatments were processed for histological and electron microscopic studies, as these concentrations took the least time for paralysis and death to occur. RESULT: With an increase in the concentration of the leaf extract from 10 to 80 mg/mL and praziquantel from 0.0005 to 0.005 mg/mL, the time for the onset of paralysis and death was shortened. The treated parasites lost their spontaneous movement rapidly followed by death. Electron microscopic observations revealed disruptions in the tegument and parenchymal layer, accompanied by deformities in cell organelles. DISCUSSION AND CONCLUSION: Extensive structural alterations in the tegument indicate that the plant-derived components cause permeability changes in the parasite leading to paralysis and subsequent death. These observations suggest that phytochemicals present in C. viscosum have vermifugal or vermicidal activity, and thus may be exploited as alternative chemotherapeutic agents.
[Mh] Termos MeSH primário: Anticestoides/farmacologia
Cestoides/efeitos dos fármacos
Clerodendrum/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Anticestoides/isolamento & purificação
Cestoides/crescimento & desenvolvimento
Cestoides/ultraestrutura
Relação Dose-Resposta a Droga
Etanol/química
Microscopia Eletrônica de Varredura
Microscopia Eletrônica de Transmissão
Testes de Sensibilidade Parasitária
Fitoterapia
Extratos Vegetais/isolamento & purificação
Folhas de Planta/química
Plantas Medicinais
Praziquantel/farmacologia
Solventes/química
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticestodal Agents); 0 (Plant Extracts); 0 (Solvents); 3K9958V90M (Ethanol); 6490C9U457 (Praziquantel)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160906
[St] Status:MEDLINE
[do] DOI:10.1080/13880209.2016.1226367


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[PMID]:27502443
[Au] Autor:Bhari N; Saginatham H; Verma KK
[Ad] Endereço:All India Institute of Medical Sciences.
[Ti] Título:Tacrolimus induced dermatophyte infection overlying a plaque morphea.
[So] Source:Dermatol Ther;30(1), 2017 Jan.
[Is] ISSN:1529-8019
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Imunossupressores/efeitos adversos
Esclerodermia Localizada/tratamento farmacológico
Tacrolimo/efeitos adversos
Tinha/induzido quimicamente
[Mh] Termos MeSH secundário: Administração Cutânea
Administração Oral
Adolescente
Anticestoides/administração & dosagem
Seres Humanos
Imunossupressores/administração & dosagem
Masculino
Naftalenos/administração & dosagem
Esclerodermia Localizada/diagnóstico
Creme para a Pele
Tacrolimo/administração & dosagem
Tinha/tratamento farmacológico
Tinha/parasitologia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
0 (Anticestodal Agents); 0 (Immunosuppressive Agents); 0 (Naphthalenes); G7RIW8S0XP (terbinafine); WM0HAQ4WNM (Tacrolimus)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160810
[St] Status:MEDLINE
[do] DOI:10.1111/dth.12395


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[PMID]:26802488
[Au] Autor:Wu HW; Ito A; Ai L; Zhou XN; Acosta LP; Lee Willingham A
[Ad] Endereço:Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, RI, USA; Department of Pediatrics, Rhode Island Hospital, Brown University Medical School, Providence, RI, USA. Electronic address: Haiwei_wu@Brown.edu.
[Ti] Título:Cysticercosis/taeniasis endemicity in Southeast Asia: Current status and control measures.
[So] Source:Acta Trop;165:121-132, 2017 01.
[Is] ISSN:1873-6254
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The parasitic zoonoses cysticercosis/taeniasis is among the 17 major Neglected Tropical Diseases (NTDs) identified by the WHO as a focus for research and control. It is caused by a larval stage (cysticercus) infection of Taenia solium tapeworm in both humans and pigs. Cysticercosis occurs in many resource-poor countries, especially those with warm and mild climates in the regions of Latin America (LA), Asia and Sub-Saharan Africa (SSA). The prevalence of human cysticercosis is marked in those areas where individuals are traditionally keen to consume raw or insufficiently cooked pork and/or where the husbandry of pigs is improper. The worldwide burden of cysticercosis is unclear and notably, large-scale control initiatives are lacking in all regions. This review focuses on the current endemic status of cysticercosis caused by T. solium infection in both humans and pigs living in 13 Southeast Asian countries. We will also emphasize epidemiological data as well as prevention and control of human neurocysticercosis.
[Mh] Termos MeSH primário: Criação de Animais Domésticos/normas
Doenças Transmissíveis Emergentes/parasitologia
Cisticercose/epidemiologia
Carne Vermelha/parasitologia
Sus scrofa/parasitologia
Doenças dos Suínos/parasitologia
Taenia solium/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Anticestoides/uso terapêutico
Ásia Sudeste/epidemiologia
Doenças Transmissíveis Emergentes/epidemiologia
Doenças Transmissíveis Emergentes/prevenção & controle
Cisticercose/prevenção & controle
Cisticercose/veterinária
Seres Humanos
Prevalência
Saúde Pública
Suínos
Doenças dos Suínos/epidemiologia
Doenças dos Suínos/prevenção & controle
Zoonoses/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anticestodal Agents)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160124
[St] Status:MEDLINE


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[PMID]:26276698
[Au] Autor:Devleesschauwer B; Allepuz A; Dermauw V; Johansen MV; Laranjo-González M; Smit GS; Sotiraki S; Trevisan C; Wardrop NA; Dorny P; Gabriël S
[Ad] Endereço:Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium. Electronic address: brechtdv@gmail.com.
[Ti] Título:Taenia solium in Europe: Still endemic?
[So] Source:Acta Trop;165:96-99, 2017 Jan.
[Is] ISSN:1873-6254
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The pork tapeworm, Taenia solium, causes an important economic and health burden, mainly in rural or marginalized communities of sub-Saharan Africa, Asia, and Latin-America. Although improved pig rearing conditions seem to have eliminated the parasite in most Western European countries, little is known about the true endemicity status of T. solium throughout Europe. Three recent reviews indicate that autochthonous human T. solium taeniasis/cysticercosis may be possible in Europe, but that current peer-reviewed literature is biased towards Western Europe. Officially reported data on porcine cysticercosis are highly insufficient. Favourable conditions for local T. solium transmission still exist in eastern parts of Europe, although the ongoing integration of the European Union is speeding up modernisation and intensification of the pig sector. Further evidence is urgently needed to fill the gaps on the European T. solium endemicity map. We urge to make human cysticercosis notifiable and to improve the reporting of porcine cysticercosis.
[Mh] Termos MeSH primário: Doenças Transmissíveis Emergentes/veterinária
Carne Vermelha/parasitologia
Doenças dos Suínos/epidemiologia
Doenças dos Suínos/parasitologia
Suínos/parasitologia
Taenia solium/isolamento & purificação
Teníase/veterinária
[Mh] Termos MeSH secundário: Criação de Animais Domésticos
Animais
Anticestoides/uso terapêutico
Doenças Transmissíveis Emergentes/epidemiologia
Doenças Transmissíveis Emergentes/prevenção & controle
Doenças Transmissíveis Emergentes/transmissão
Europa (Continente)/epidemiologia
Seres Humanos
Prevalência
Saúde Pública
Fatores de Risco
Saúde da População Rural
População Rural
Doenças dos Suínos/transmissão
Teníase/epidemiologia
Teníase/parasitologia
Teníase/transmissão
Zoonoses
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticestodal Agents)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150816
[St] Status:MEDLINE



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