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Pesquisa : D27.505.954.158.515 [Categoria DeCS]
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[Au] Autor:Kim MJ; Lee Y; Jon S; Lee DY
[Ad] Endereço:Department of Bioengineering, College of Engineering, and BK21 PLUS Future Biopharmaceutical Human Resources Training and Research Team, Hanyang University, Seoul 04763, Republic of Korea.
[Ti] Título:PEGylated bilirubin nanoparticle as an anti-oxidative and anti-inflammatory demulcent in pancreatic islet xenotransplantation.
[So] Source:Biomaterials;133:242-252, 2017 Jul.
[Is] ISSN:1878-5905
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Transplanted islets suffer hypoxic stress, which leads to nonspecific inflammation. This is the major cause of islet graft failure during the early stage of intrahepatic islet transplantation. Although bilirubin has shown potent anti-oxidative and anti-inflammatory functions, its clinical applications have been limited due to its insolubility and short half-life. To overcome this problem, novel amphiphilic bilirubin nanoparticles are designed. Hydrophilic poly(ethylene glycol) (PEG) is conjugated to the hydrophobic bilirubin molecule. Then, the PEG-bilirubin conjugates form nanoparticles via self-assembly, i.e., so-called to BRNPs. BRNPs can protect islet cells not only from chemically induced oxidative stress by scavenging reactive oxygen species molecules, but also from activated macrophages by suppressing cytokine release. Importantly, in vivo experiments demonstrate that BRNP treatment can dramatically and significantly prolong islet graft survival compared to bilirubin treatment. In addition, immunohistochemical analysis shows BRNPs have potent anti-oxidative and anti-inflammatory capabilities. Collectively, novel BRNPs can be a new potent remedy for successful islet transplantation.
[Mh] Termos MeSH primário: Bilirrubina/química
Bilirrubina/uso terapêutico
Demulcentes/uso terapêutico
Inflamação/tratamento farmacológico
Ilhotas Pancreáticas/efeitos dos fármacos
Ilhotas Pancreáticas/metabolismo
[Mh] Termos MeSH secundário: Animais
Diabetes Mellitus/metabolismo
Camundongos Endogâmicos BALB C
Células RAW 264.7
Ratos Sprague-Dawley
Espécies Reativas de Oxigênio/metabolismo
Transplante Heterólogo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Demulcents); 0 (Reactive Oxygen Species); 30IQX730WE (Polyethylene Glycols); RFM9X3LJ49 (Bilirubin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE

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[Au] Autor:Ellemunter H; Eder J; Fuchs S; Gappa M; Steinkamp G
[Ad] Endereço:Medical University of Innsbruck, Department of Child and Adolescent Health, Division of Cardiology, Pulmonology, Allergology, and Cystic Fibrosis, Cystic Fibrosis Centre, Anichstrasse 35, A-6020 Innsbruck, Austria. Electronic address:
[Ti] Título:Long-term improvement of lung clearance index in patients with mild cystic fibrosis lung disease: Does hypertonic saline play a role?
[So] Source:J Cyst Fibros;15(1):123-6, 2016 Jan.
[Is] ISSN:1873-5010
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:To assess whether long-term inhalation with hypertonic saline is able to halt the progression of mild CF lung disease, we analysed longitudinal data of lung clearance index (LCI) and spirometry. A total of 34 patients with mild lung disease (FEV1 ≥ 70% of predicted) had at least one LCI result before and ≥2 LCI measurements after start of hypertonic saline (HS) therapy. After a mean follow-up of 39.7 (SD 7.4) months after starting HS, LCI improved significantly from 7.89 (SD 1.35) at baseline to 6.96 (SD 1.03), and 19/34 patients had a normal LCI value at the last measurement. No decrease in mean FEV1 was observed. Thus, ventilation inhomogeneity can improve in patients with mild lung disease.
[Mh] Termos MeSH primário: Fibrose Cística
Depuração Mucociliar/efeitos dos fármacos
Solução Salina Hipertônica/administração & dosagem
[Mh] Termos MeSH secundário: Administração por Inalação
Fibrose Cística/diagnóstico
Fibrose Cística/tratamento farmacológico
Fibrose Cística/fisiopatologia
Demulcentes/administração & dosagem
Progressão da Doença
Seres Humanos
Gravidade do Paciente
Testes de Função Respiratória/métodos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Demulcents); 0 (Saline Solution, Hypertonic)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150721
[St] Status:MEDLINE

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[Au] Autor:Gruber S; Hamedinger D; Bozsaky E; Schmidt M; Wolfram K; Haagen J; Habelt B; Puttrich M; Dörr W
[Ad] Endereço:Dept. Radiation Oncology/CD Lab. Med. Radiation Research for Radiation Oncology, Comprehensive Cancer Center, Medical University/AKH Vienna, Austria.
[Ti] Título:Local hypoxia in oral mucosa (mouse) during daily fractionated irradiation - Effect of pentoxifylline.
[So] Source:Radiother Oncol;116(3):404-8, 2015 Sep.
[Is] ISSN:1879-0887
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:PURPOSE: A significant reduction of radiation-induced oral mucositis by systemic application of pentoxifylline has been demonstrated in a mouse tongue model. However, the underlying mechanisms remain unclear. The present study focuses on the development of local hypoxia in mouse tongue during daily fractionated irradiation and a potential modulation by pentoxifylline. MATERIALS AND METHODS: Daily fractionated irradiation with 5×3Gy/week (days 0-4, 7-11) was given to the snouts of mice. Groups of 3 animals per day were sacrificed between day 0 and 14. Pentoxifylline (15mg/kg, s.c.) was administered daily from day -5 to the day before the mice were sacrificed. The expression of intrinsic hypoxia markers HIF-1α and GLUT1 in the epithelium of the lower tongue surface was analysed by immunohistochemistry in 3 animals per day; the percentage of positive epithelial cells and the staining intensity were analysed as endpoints. RESULTS: Compared to untreated control tissue, fractionated irradiation resulted in a progressive increase in the expression of both hypoxia markers. This effect was significantly reduced by pentoxifylline. CONCLUSION: An early onset of local hypoxia occurs during fractionated irradiation in mouse tongue epithelium. The effect is markedly reduced by the mucoprotective agent pentoxifylline, suggesting a mucositis-promoting role of hypoxia; this, however, deserves further investigation.
[Mh] Termos MeSH primário: Demulcentes/farmacologia
Mucosa Bucal/efeitos da radiação
Protetores contra Radiação/farmacologia
Estomatite/prevenção & controle
[Mh] Termos MeSH secundário: Análise de Variância
Contagem de Células
Modelos Animais de Doenças
Fracionamento de Dose
Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo
Camundongos Endogâmicos C3H
Língua/efeitos da radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Demulcents); 0 (Hypoxia-Inducible Factor 1, alpha Subunit); 0 (Radiation-Protective Agents); SD6QCT3TSU (Pentoxifylline)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150420
[St] Status:MEDLINE

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