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[PMID]:29371217
[Au] Autor:Jarvis S; Dassan P; Piercy CN
[Ad] Endereço:Imperial College Healthcare NHS Trust, London W12 0HS, UK sheba.jarvis@imperial.ac.uk.
[Ti] Título:Managing migraine in pregnancy.
[So] Source:BMJ;360:k80, 2018 01 25.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Enxaqueca com Aura/tratamento farmacológico
Complicações na Gravidez/tratamento farmacológico
[Mh] Termos MeSH secundário: Acetaminofen/uso terapêutico
Adulto
Analgésicos não Entorpecentes/uso terapêutico
Antieméticos/uso terapêutico
Feminino
Seres Humanos
Gravidez
Sumatriptana/uso terapêutico
Vasoconstritores/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Non-Narcotic); 0 (Antiemetics); 0 (Vasoconstrictor Agents); 362O9ITL9D (Acetaminophen); 8R78F6L9VO (Sumatriptan)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180127
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.k80


  2 / 17148 MEDLINE  
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[PMID]:29428027
[Au] Autor:Allen CJ; Subhawong TK; Hanna MM; Chelala L; Bullock MR; Schulman CI; Proctor KG
[Ti] Título:Does Vasopressin Exacerbate Cerebral Edema in Patients with Severe Traumatic Brain Injury?
[So] Source:Am Surg;84(1):43-50, 2018 Jan 01.
[Is] ISSN:1555-9823
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Arginine vasopressin (AVP) is often used as an alternative pressor to catecholamines (CATs). However, unlike CATs, AVP is a powerful antidiuretic that could promote edema. We tested the hypothesis that AVP promoted cerebral edema and/or increased requirements for osmotherapy, relative to those who received CATs, for cerebral perfusion pressure (CPP) management after traumatic brain injury (TBI). This is a retrospective review of 286 consecutive TBI patients with intracranial pressure monitoring at a single institution from September 2008 to January 2015. Cerebral edema was quantitated using CT attenuation in prespecified areas of gray and white matter. RESULTS: To maintain CPP >60 mm Hg, 205 patients required no vasopressors, 41 received a single CAT, 12 received AVP, and 28 required both. Those who required no pressors were generally less injured; required less hyperosmolar therapy and less total fluid; and had lower plasma Na, lower intracranial pressure, less edema, and lower mortality (all P < 0.05). Edema; daily mean, minimum, and maximum Na levels; and mortality were similar with AVP versus CATs, but the daily requirement of mannitol and 3 per cent NaCl were reduced by 45 and 35 per cent (both P < 0.05). In patients with TBI who required CPP therapy, AVP reduced the requirements for hyperosmolar therapy and did not delay resolution or increase cerebral edema compared with CATs.
[Mh] Termos MeSH primário: Edema Encefálico/tratamento farmacológico
Lesões Encefálicas Traumáticas/tratamento farmacológico
Circulação Cerebrovascular/efeitos dos fármacos
Vasoconstritores/administração & dosagem
Vasopressinas/administração & dosagem
[Mh] Termos MeSH secundário: Adulto
Edema Encefálico/diagnóstico
Edema Encefálico/etiologia
Edema Encefálico/mortalidade
Lesões Encefálicas Traumáticas/complicações
Lesões Encefálicas Traumáticas/diagnóstico
Lesões Encefálicas Traumáticas/mortalidade
Catecolaminas/uso terapêutico
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Índices de Gravidade do Trauma
Resultado do Tratamento
Vasoconstritores/efeitos adversos
Vasopressinas/efeitos adversos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Catecholamines); 0 (Vasoconstrictor Agents); 11000-17-2 (Vasopressins)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180212
[St] Status:MEDLINE


  3 / 17148 MEDLINE  
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[PMID]:29422100
[Au] Autor:Mikkelsen MLG; Ambrus R; Rasmussen R; Miles JE; Poulsen HH; Moltke FB; Eriksen T
[Ad] Endereço:Department of Veterinary Clinical Sciences, University of Copenhagen, 16 Dyrlægevej, 1870, Frederiksberg C, Denmark. mailo@sund.ku.dk.
[Ti] Título:The influence of norepinephrine and phenylephrine on cerebral perfusion and oxygenation during propofol-remifentanil and propofol-remifentanil-dexmedetomidine anaesthesia in piglets.
[So] Source:Acta Vet Scand;60(1):8, 2018 Feb 08.
[Is] ISSN:1751-0147
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Vasopressors are frequently used to increase blood pressure in order to ensure sufficient cerebral perfusion and oxygenation (CPO) during hypotensive periods in anaesthetized patients. Efficacy depends both on the vasopressor and anaesthetic protocol used. Propofol-remifentanil total intravenous anaesthesia (TIVA) is common in human anaesthesia, and dexmedetomidine is increasingly used as adjuvant to facilitate better haemodynamic stability and analgesia. Little is known of its interaction with vasopressors and subsequent effects on CPO. This study investigates the CPO response to infusions of norepinephrine and phenylephrine in piglets during propofol-remifentanil and propofol-remifentanil-dexmedetomidine anaesthesia. Sixteen healthy female piglets (25-34 kg) were randomly allocated into a two-arm parallel group design with either normal blood pressure (NBP) or induced low blood pressure (LBP). Anaesthesia was induced with propofol without premedication and maintained with propofol-remifentanil TIVA, and finally supplemented with continuous infusion of dexmedetomidine. Norepinephrine and phenylephrine were infused in consecutive intervention periods before and after addition of dexmedetomidine. Cerebral perfusion measured by laser speckle contrast imaging was related to cerebral oxygenation as measured by an intracerebral Licox probe (partial pressure of oxygen) and transcranial near infrared spectroscopy technology (NIRS) (cerebral oxygen saturation). RESULTS: During propofol-remifentanil anaesthesia, increases in blood pressure by norepinephrine and phenylephrine did not change cerebral perfusion significantly, but cerebral partial pressure of oxygen (Licox) increased following vasopressors in both groups and increases following norepinephrine were significant (NBP: P = 0.04, LBP: P = 0.02). In contrast, cerebral oxygen saturation (NIRS) fell significantly in NBP following phenylephrine (P = 0.003), and following both norepinephrine (P = 0.02) and phenylephrine (P = 0.002) in LBP. Blood pressure increase by both norepinephrine and phenylephrine during propofol-remifentanil-dexmedetomidine anaesthesia was not followed by significant changes in cerebral perfusion. Licox measures increased significantly following both vasopressors in both groups, whereas the decreases in NIRS measures were only significant in the NBP group. CONCLUSIONS: Cerebral partial pressure of oxygen measured by Licox increased significantly in concert with the vasopressor induced increases in blood pressure in healthy piglets with both normal and low blood pressure. Cerebral oxygenation assessed by intracerebral Licox and transcranial NIRS showed opposing results to vasopressor infusions.
[Mh] Termos MeSH primário: Anestesia/veterinária
Circulação Sanguínea/efeitos dos fármacos
Córtex Cerebral/efeitos dos fármacos
[Mh] Termos MeSH secundário: Anestésicos Intravenosos/administração & dosagem
Animais
Córtex Cerebral/irrigação sanguínea
Córtex Cerebral/metabolismo
Dexmedetomidina/administração & dosagem
Hipnóticos e Sedativos/administração & dosagem
Norepinefrina/farmacologia
Oxigênio/metabolismo
Fenilefrina/farmacologia
Piperidinas/administração & dosagem
Propofol/administração & dosagem
Suínos
Vasoconstritores/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Intravenous); 0 (Hypnotics and Sedatives); 0 (Piperidines); 0 (Vasoconstrictor Agents); 1WS297W6MV (Phenylephrine); 67VB76HONO (Dexmedetomidine); P10582JYYK (remifentanil); S88TT14065 (Oxygen); X4W3ENH1CV (Norepinephrine); YI7VU623SF (Propofol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180210
[St] Status:MEDLINE
[do] DOI:10.1186/s13028-018-0362-z


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[PMID]:29384879
[Au] Autor:Jung KJ; Nho JH; Cho HK; Hong S; Won SH; Chun DI; Kim B
[Ad] Endereço:Department of Orthopaedic Surgery, Soonchunhyang University Hospital Cheonan, Cheonan-si.
[Ti] Título:Amputation of multiple limbs caused by use of inotropics: Case report, a report of 4 cases.
[So] Source:Medicine (Baltimore);97(5):e9800, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: We present 4 cases of symmetrical peripheral gangrene (SPG) associated with use of inotropic agent to elevate blood pressure. SPG is a relatively rare phenomenon characterized by symmetrical distal ischemic damage that leads to gangrene of 2 or more sites in the absence of large blood vessel obstruction, where vasoconstriction rather than thrombosis is implicated as the underlying pathophysiology. We present 4 SPG cases of the multiple limbs amputation, associated with inevitable use of inotropic agents. PATIENT CONCERNS: Inotropic agents including dopamine and norepinephrine are used frequently in the treatment of hypotension, and its effectiveness in treating shock is firmly established. However, it can be caused peripheral gangrene by prolonged administration of high dose inotropics, inducing the constant contraction of the peripheral blood vessels. DIAGNOSIS: These 4 patients had different clinical histories and background factors, but each experienced sepsis. The level of amputation is determined by the line of demarcation in concert with considerations of the biomechanics of stump stability, weight bearing, and ambulation. INTERVENTIONS: After recovering of general conditions and completion of demarcation, these 4 patients underwent the amputation of multiple limbs.(bilateral amputations of upper extremities or bilateral amputations of lower extremities). OUTCOMES: In each patient, there was no additional amputation caused by extension of SPG, and the rehabilitation with appropriate orthosis was performed. Treatment of underlying disease were continued too. LESSONS: It is important to alert the possibility of amputations, according to the use of inevitable inotropics. We recommended the careful use of the inotropic agents to the physicians in treating septic shock.
[Mh] Termos MeSH primário: Amputação
Cardiotônicos/efeitos adversos
Dopamina/efeitos adversos
Extremidades/irrigação sanguínea
Extremidades/patologia
Norepinefrina/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Idoso
Extremidades/cirurgia
Feminino
Gangrena
Seres Humanos
Masculino
Meia-Idade
Vasoconstritores/efeitos adversos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cardiotonic Agents); 0 (Vasoconstrictor Agents); VTD58H1Z2X (Dopamine); X4W3ENH1CV (Norepinephrine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009800


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[PMID]:28452978
[Au] Autor:Serna-Higuita LM; Nieto-Ríos JF; Contreras-Saldarriaga JE; Escobar-Cataño JF; Gómez-Ramírez LA; Montoya-Giraldo JD; Parra-Rodas E; Parra-Rodas LM; Valderrama-Torres JC; Jaimes F
[Ad] Endereço:Instituto de Bioestadistica, Hospital Universitario de Tübingen, Tübingen, Alemania. Address: Oficina de Nefrología y Trasplante Renal, Hospital Pablo Tobón Uribe, Calle 78b 69-240, Medellín, Colombia. Email: lm.serna@hotmail.com.
[Ti] Título:Risk factors for acute kidney injury in a pediatric intensive care unit: a retrospective cohort study.
[Ti] Título:Factores de riesgo de lesión renal aguda en una unidad de cuidados intensivos pediátrica: cohorte retrospectiva..
[So] Source:Medwave;17(3):e6940, 2017 Apr 27.
[Is] ISSN:0717-6384
[Cp] País de publicação:Chile
[La] Idioma:spa; eng
[Ab] Resumo:BACKGROUND: The incidence of acute kidney injury in the pediatric population and its associated risk factors are currently not clear. OBJECTIVES: The objective of the study was to assess the incidence of acute kidney injury in critically ill pediatric patients and to determine its associated risk factors. METHODS: We conducted a retrospective study of pediatric patients (<14 years old) admitted to a tertiary pediatric intensive care unit. Acute kidney injury (AKI) was classified using the Kidney Disease: Improving Global Outcomes definition KDIGO. RESULTS: A total number of 382 patients were assessed: acute kidney injury was found in 11.5% of them (incidence rate 0.99 persons-day). The following parameters analyzed with multivariate regression analysis were associated with acute kidney injury: low platelet count (R = 2.947; 95% CI= 1.276-6.805) and the need of vasopressor support (OR= 4.601; 95% CI= 1.665-12.710). Children with acute kidney injury had an increased length of stay in the hospital and an increased mortality compared with patients with no kidney injury (19 days vs. 5 days and 3.7/person-day vs. 0.32/person-day). CONCLUSIONS: Acute kidney injury is common among critically ill children and it is associated with adverse outcomes, including increased length of stay in the hospital and death. Low platelet count and vasopressor support were independently associated with the development of acute kidney injury in this population.
[Mh] Termos MeSH primário: Lesão Renal Aguda/etiologia
Hospitalização/estatística & dados numéricos
Unidades de Terapia Intensiva Pediátrica
Tempo de Internação
[Mh] Termos MeSH secundário: Lesão Renal Aguda/epidemiologia
Lesão Renal Aguda/mortalidade
Adolescente
Criança
Pré-Escolar
Estudos de Coortes
Estado Terminal
Feminino
Seres Humanos
Incidência
Lactente
Masculino
Análise Multivariada
Contagem de Plaquetas
Análise de Regressão
Estudos Retrospectivos
Fatores de Risco
Vasoconstritores/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Vasoconstrictor Agents)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.5867/medwave.2017.03.6940


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[PMID]:27774825
[Au] Autor:Vincent JL; Leone M
[Ad] Endereço:a Department of Intensive Care , Erasme Hospital, Université Libre de Bruxelles , Brussels , Belgium.
[Ti] Título:Optimum treatment of vasopressor-dependent distributive shock.
[So] Source:Expert Rev Anti Infect Ther;15(1):5-10, 2017 01.
[Is] ISSN:1744-8336
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Distributive shock is associated with decreased systemic vascular resistance and altered oxygen extraction. Septic shock is the most frequent form of distributive shock. In shock states, duration of hypotension is associated with poor outcomes. The speed at which treatment to restore adequate perfusion pressure is initiated is, therefore, important to improve survival. Areas covered: This review presents an overview of the literature related to the management of vasopressor-dependent distributive shock, and in particular the relationship between arterial pressure and organ perfusion and function. Studies that have tried to determine an optimal blood pressure level are discussed demonstrating that it is difficult to define and will vary according to individual patient factors, including age and a history of chronic hypertension. An initial target mean arterial pressure (MAP) of 65-70 mmHg is probably sufficient in most patients. The influence of increasing MAP on the microcirculation is also covered. Expert commentary: Microcirculatory monitoring may be the best way to individualize management of these patients, but remains experimental at present. In the meantime, repeated blood lactate levels and venous oxygen saturations, combined with hemodynamic variables and the clinical picture, can provide an indication of the response to treatment and adequacy of tissue perfusion.
[Mh] Termos MeSH primário: Pressão Sanguínea/efeitos dos fármacos
Microcirculação/efeitos dos fármacos
Choque Séptico/tratamento farmacológico
Resistência Vascular/efeitos dos fármacos
Vasoconstritores
[Mh] Termos MeSH secundário: Velocidade do Fluxo Sanguíneo/efeitos dos fármacos
Seres Humanos
Guias de Prática Clínica como Assunto
Choque Séptico/fisiopatologia
Vasoconstritores/administração & dosagem
Vasoconstritores/efeitos adversos
Vasoconstritores/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Vasoconstrictor Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161108
[St] Status:MEDLINE


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[PMID]:29283546
[Au] Autor:Khan QS; Tucker P; Lokhande A
[Ti] Título:Priapism: What cause: mental illness, psychotropic medications or poly-substance abuse?
[So] Source:J Okla State Med Assoc;109(11):515-7, 2016 11.
[Is] ISSN:0030-1876
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We present a case of priapism in a homeless patient with a psychiatric history of major depression, PTSD, polysubstance abuse (alcohol and cocaine) and past psychotropic medication use who was admitted to a local hospital for suicidal ideation. Priapism is a serious urological and a medical emergency which has often been associated with psychotropic medications (including the antidepressant trazodone), use of marijuana and alcohol, and other factors. This clinical case highlights the additive risks of medications and comorbid conditions in contributing to onset of priapism, emphasizing the importance of any pre-existing medical illness, diagnoses, and comorbid mental illnesses. Moreover, clinicians should consider potential side effects of all medications used and their drug interactions as they manage patients who develop this condition.
[Mh] Termos MeSH primário: Transtorno Depressivo Maior/tratamento farmacológico
Inibidores da Fosfodiesterase 5/efeitos adversos
Priapismo/induzido quimicamente
Hiperplasia Prostática/tratamento farmacológico
Inibidores da Captação de Serotonina/efeitos adversos
Citrato de Sildenafila/efeitos adversos
Distúrbios do Início e da Manutenção do Sono/tratamento farmacológico
Trazodona/efeitos adversos
[Mh] Termos MeSH secundário: Antagonistas de Receptores Adrenérgicos alfa 1/uso terapêutico
Transtorno Depressivo Maior/complicações
Hepatite C/complicações
Seres Humanos
Masculino
Meia-Idade
Fenilefrina/uso terapêutico
Priapismo/tratamento farmacológico
Hiperplasia Prostática/complicações
Distúrbios do Início e da Manutenção do Sono/complicações
Transtornos Relacionados ao Uso de Substâncias/complicações
Sulfonamidas/uso terapêutico
Vasoconstritores/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenergic alpha-1 Receptor Antagonists); 0 (Phosphodiesterase 5 Inhibitors); 0 (Serotonin Uptake Inhibitors); 0 (Sulfonamides); 0 (Vasoconstrictor Agents); 1WS297W6MV (Phenylephrine); BW9B0ZE037 (Sildenafil Citrate); G3P28OML5I (tamsulosin); YBK48BXK30 (Trazodone)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE


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[PMID]:29203627
[Au] Autor:Schinzari F; Tesauro M; Veneziani A; Mores N; Di Daniele N; Cardillo C
[Ad] Endereço:From the Policlinico A. Gemelli, Rome, Italy (F.S., A.V., N.M., C.C.); Department of Internal Medicine, University of Tor Vergata, Rome, Italy (M.T., N.D.D.); and Departments of Surgery (A.V.), Pharmacology (N.M.), and Internal Medicine (C.C.), Catholic University, Rome, Italy.
[Ti] Título:Favorable Vascular Actions of Angiotensin-(1-7) in Human Obesity.
[So] Source:Hypertension;71(1):185-191, 2018 01.
[Is] ISSN:1524-4563
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Obese patients have vascular dysfunction related to impaired insulin-stimulated vasodilation and increased endothelin-1-mediated vasoconstriction. In contrast to the harmful vascular actions of angiotensin (Ang) II, the angiotensin-converting enzyme 2 product Ang-(1-7) has shown to exert cardiovascular and metabolic benefits in experimental models through stimulation of the Mas receptor. We, therefore, examined the effects of exogenous Ang-(1-7) on vasodilator tone and endothelin-1-dependent vasoconstriction in obese patients. Intra-arterial infusion of Ang-(1-7) (10 nmol/min) resulted in significant increase in unstimulated forearm flow ( =0.03), an effect that was not affected by the Mas receptor antagonist A779 (10 nmol/min; >0.05). In the absence of hyperinsulinemia, however, forearm flow responses to graded doses of acetylcholine and sodium nitroprusside were not different during Ang-(1-7) administration compared with saline (both >0.05). During infusion of regular insulin (0.15 mU/kg per minute), by contrast, endothelium-dependent vasodilator response to acetylcholine was significantly enhanced by Ang-(1-7) ( =0.04 versus saline), whereas endothelium-independent response to sodium nitroprusside was not modified ( =0.91). Finally, Ang-(1-7) decreased the vasodilator response to endothelin A receptor blockade (BQ-123; 10 nmol/min) compared with saline (6±1% versus 93±17%; <0.001); nitric oxide inhibition by l- -monomethylarginine (4 µmol/min) during concurrent endothelin A antagonism resulted in similar vasoconstriction in the absence or presence of Ang-(1-7 Ang-(1-7) ( =0.69). Our findings indicate that in obese patients Ang-(1-7) has favorable effects not only to improve insulin-stimulated endothelium-dependent vasodilation but also to blunt endothelin-1-dependent vasoconstrictor tone. These findings provide support for targeting Ang-(1-7) to counteract the hemodynamic abnormalities of human obesity.
[Mh] Termos MeSH primário: Angiotensina I/metabolismo
Endotelina-1/metabolismo
Insulina
Obesidade
Fragmentos de Peptídeos/metabolismo
Fluxo Sanguíneo Regional/efeitos dos fármacos
Vasoconstrição
Vasodilatação
[Mh] Termos MeSH secundário: Adulto
Feminino
Antebraço/irrigação sanguínea
Seres Humanos
Insulina/metabolismo
Insulina/farmacocinética
Masculino
Meia-Idade
Obesidade/metabolismo
Obesidade/fisiopatologia
Receptor de Endotelina A/metabolismo
Fluxo Sanguíneo Regional/fisiologia
Estatística como Assunto
Vasoconstrição/efeitos dos fármacos
Vasoconstrição/fisiologia
Vasoconstritores/farmacologia
Vasodilatação/efeitos dos fármacos
Vasodilatação/fisiologia
Vasodilatadores/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Endothelin-1); 0 (Insulin); 0 (Peptide Fragments); 0 (Receptor, Endothelin A); 0 (Vasoconstrictor Agents); 0 (Vasodilator Agents); 9041-90-1 (Angiotensin I); IJ3FUK8MOF (angiotensin I (1-7))
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180113
[Lr] Data última revisão:
180113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1161/HYPERTENSIONAHA.117.10280


  9 / 17148 MEDLINE  
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[PMID]:28461606
[Au] Autor:Ueki N; Kanasaki K; Kanasaki M; Takeda S; Koya D
[Ad] Endereço:From the Department of Obstetrics and Gynecology, Juntendo University, Tokyo, Japan (N.U., S.T.); and Department of Diabetology and Endocrinology (N.U., K.K., M.K., D.K.) and Division of Anticipatory Molecular Food Science and Technology, Medical Research Institute (K.K., D.K.), Kanazawa Medical Uni
[Ti] Título:Catechol-O-Methyltransferase Deficiency Leads to Hypersensitivity of the Pressor Response Against Angiotensin II.
[So] Source:Hypertension;69(6):1156-1164, 2017 06.
[Is] ISSN:1524-4563
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Catechol-O-methyltransferase (COMT) metabolizes 2-hydroxyestradiol into 2-methoxyestradiol (2-ME); COMT deficiency has shown to be associated with hypertension in men and preeclampsia, the disease associated with hypersensitivity of pressor response against angiotensin II (Ang II). Here, we found that COMT deficiency could explain the hypersensitivity of pressor response against Ang II in mice because of the lack of 2-ME-dependent suppression of angiotensin II receptor type 1 (AT1R). Male C57BL/6 mice were subjected to COMT inhibitor (COMTi: 25 mg/kg per day) or oil (control) for 4 weeks, with or without low-dose Ang II infusion (ANGII: 70 ng/kg per minute) for the last 3 weeks. The Ang II-infused mice were treated with 2-ME (10 ng/d) or vehicle for the last 1 week. We obtained the following experimental groups: control, ANGII, COMTi, COMTi+ANGII, and COMTi+ANGII+2-ME. We performed similar experiments using the in vivo administration of small interfering RNA of COMT instead of COMTi. Neither ANGII nor COMTi exhibited significant alterations in systolic blood pressure. Compared with ANGII or COMTi, COMTi+ANGII displayed significantly higher systolic blood pressure, albuminuria, and glomerular endotheliosis; 2-ME normalized such alterations. Similar phenotypes were observed in COMT small interfering RNA-treated mice. In the aorta of COMT-deficient mice, AT1R expression was increased; 2-ME suppressed AT1R expression. The 2-ME exhibited peroxisome proliferator-activated receptor γ agonistic activity in vitro and ex vivo plasma from pregnant female mice as well. In vitro, 2-ME suppressed both basal and Ang II-induced AT1R levels in a peroxisome proliferator-activated receptor γ-dependent manner. The 2-ME is relevant to combat COMT deficiency-associated hypertensive disorders via suppression of AT1R by its peroxisome proliferator-activated receptor γ activity.
[Mh] Termos MeSH primário: Angiotensina II/farmacologia
Catecol O-Metiltransferase/deficiência
Hipersensibilidade a Drogas/fisiopatologia
Pré-Eclâmpsia/fisiopatologia
Prenhez
Tiazolidinedionas/farmacologia
[Mh] Termos MeSH secundário: Animais
Feminino
Hipertensão/tratamento farmacológico
Hipertensão/fisiopatologia
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
PPAR gama/metabolismo
Pré-Eclâmpsia/tratamento farmacológico
Gravidez
Receptor Tipo 1 de Angiotensina/metabolismo
Valores de Referência
Vasoconstritores/farmacologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (PPAR gamma); 0 (Receptor, Angiotensin, Type 1); 0 (Thiazolidinediones); 0 (Vasoconstrictor Agents); 11128-99-7 (Angiotensin II); EC 2.1.1.6 (Catechol O-Methyltransferase); X4OV71U42S (pioglitazone)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180113
[Lr] Data última revisão:
180113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1161/HYPERTENSIONAHA.117.09247


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[PMID]:29282968
[Au] Autor:Janssens U
[Ad] Endereço:St. Antonius Hospital Eschweiler, Eschweiler, Germany uwe.janssens@sah-eschweiler.de
[Ti] Título:Angiotensin II for the Treatment of Vasodilatory Shock.
[So] Source:N Engl J Med;377(26):2603-4, 2017 12 28.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Angiotensina II
Choque
[Mh] Termos MeSH secundário: Seres Humanos
Vasoconstritores
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
0 (Vasoconstrictor Agents); 11128-99-7 (Angiotensin II)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMc1714511



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