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  1 / 8 MEDLINE  
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[PMID]:26337534
[Au] Autor:Zyoud SH
[Ad] Endereço:Poison Control and Drug Information Center (PCDIC), College of Medicine and Health Sciences, An-Najah National University, Nablus, 44839, Palestine. saedzyoud@yahoo.com.
[Ti] Título:Bibliometric analysis on global Catha edulis (khat) research production during the period of 1952-2014.
[So] Source:Global Health;11:39, 2015 Sep 04.
[Is] ISSN:1744-8603
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Publication of scientific articles related to khat (Catha edulis) in peer-reviewed journals is considered a measure of research productivity. The principal objectives of this study were to quantify the research contribution related to khat at the global level, as well as to determine its relative growth rate, collaborative measures taken, productivity at the institutional level, and the most prolific journals publishing on the topic. METHODS: On the basis of title words related to khat, publications were identified for all data in Scopus bibliographic database's history up to December 31, 2014. The research productivity for the top 10 countries was evaluated in relation to the population size and gross domestic product (GDP) in 2013. RESULTS: The criteria were met by 651documents published in 51 countries. The largest number of articles associated with khat was from the UK (15.2 %), followed by Yemen (10.3 %), the USA (9.7 %) and Ethiopia (9.1 %). Ethiopia, Yemen, and Kenya had the highest productivity of publications after standardization by population size and GDP. Furthermore, Yemen achieved the highest number of collaborations, by having researchers from 19 countries. Ethiopia followed, having researchers from 16 countries. CONCLUSIONS: This bibliometric study provides a demonstration for the worldwide research activity regarding khat. The number of articles related to khat has increased rapidly over the last 10 years. The present study is a good starting point to evaluate research activity in the field of khat. Although the data shows a promising increase in the research activity, the quantity of khat-related research is still too little compared to the massive use of khat in certain countries.
[Mh] Termos MeSH primário: Catha/química
Relatório de Pesquisa/tendências
Estimulantes Históricos/uso terapêutico
[Mh] Termos MeSH secundário: Bibliometria
Catha/efeitos adversos
História do Século XX
História do Século XXI
Seres Humanos
Estimulantes Históricos/efeitos adversos
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Stimulants, Historical)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150905
[St] Status:MEDLINE
[do] DOI:10.1186/s12992-015-0124-x


  2 / 8 MEDLINE  
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[PMID]:25592952
[Au] Autor:Götti RP; Melzer J; Saller R
[Ad] Endereço:Institute of Complementary and Integrative Medicine, University Hospital Zurich, Zurich, Switzerland.
[Ti] Título:An approach to the concept of tonic: suggested definitions and historical aspects.
[So] Source:Forsch Komplementmed;21(6):413-7, 2014.
[Is] ISSN:1661-4127
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:In traditional medicine, especially CAM, the concept of (herbal) tonics has a long history in the different medical systems (TEN -- Traditional European Naturopathy; TCM - Traditional Chinese Medicine). Nevertheless, the ideas concerning the function of a tonic differ, e.g., stimulation of body functions, strengthening of organ function, enhancement of adaption, and well-being. Although no exact pharmacodynamic or pharmacokinetic properties of tonics can be given, the following general definition, even in the transcultural comparison between European and Chinese concepts, seems meaningful: A tonic is an agent that has the capability to restore and/or maintain the physiological functioning of an organ system, leading to the subjective feeling of well-being of the patient treated with it.
[Mh] Termos MeSH primário: Estimulantes Históricos
[Mh] Termos MeSH secundário: Seres Humanos
Medicina Tradicional/normas
Medicina Tradicional/tendências
Estimulantes Históricos/normas
Estimulantes Históricos/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Stimulants, Historical)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150116
[Lr] Data última revisão:
150116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150117
[St] Status:MEDLINE
[do] DOI:10.1159/000369767


  3 / 8 MEDLINE  
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[PMID]:24739929
[Au] Autor:Huang CC; Chen YM; Kan NW; Chao HL; Ho CS; Hsu MC
[Ad] Endereço:Graduate Institute of Sports Science, College of Exercise and Health Sciences, National Taiwan Sport University, Taoyuan 33301, Taiwan.
[Ti] Título:Cornu cervi pantotrichum supplementation improves exercise performance and protects against physical fatigue in mice.
[So] Source:Molecules;19(4):4669-80, 2014 Apr 15.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Cornu cervi pantotrichum (CCP) is a well-known yang-invigorating agent used in traditional Chinese medicine that can nourish the blood, tonify qi, and invigorate bones and tendons with multifunctional bioactivities. However, evidence on the effects of CCP on exercise performance and physical fatigue is limited. We evaluated the potential beneficial effects of ethanolic extract from CCP on ergogenic and antifatigue functions following a physiological challenge. Male ICR mice from four groups (n=8 per group) were orally administered CCP for 14 days at 0, 2054, and 4108 mg/kg/day, and were respectively designated as the vehicle, CCP-1X, and CCP-2X groups. The physical performance and antifatigue function were evaluated using forelimb grip strength and exhaustive swimming time as well as serum levels of lactate, ammonia, glucose, and creatine kinase after a 15-min swimming exercise. The results indicated that CCP-1X supplementation significantly improved grip strength; reduced fatigue-associated biochemical indices, including lactate and ammonia levels; and ameliorated skeletal muscle injury induced by acute exercise challenge. A trend analysis revealed that CCP supplementation significantly increased grip strength and dose-dependently reduced serum alkaline phosphatase, uric acid, triacylglycerol, and glucose levels in healthy mice. Therefore, CCP is a potential agent with an antifatigue pharmacological effect.
[Mh] Termos MeSH primário: Chifres de Veado/química
Fadiga/prevenção & controle
Esforço Físico/efeitos dos fármacos
Substâncias Protetoras/farmacologia
Estimulantes Históricos/farmacologia
[Mh] Termos MeSH secundário: Administração Oral
Fosfatase Alcalina/sangue
Amônia/sangue
Animais
Glicemia/metabolismo
Misturas Complexas/química
Cervos
Fadiga/sangue
Ácido Láctico/sangue
Masculino
Camundongos
Camundongos Endogâmicos ICR
Força Muscular/efeitos dos fármacos
Músculo Esquelético/efeitos dos fármacos
Músculo Esquelético/metabolismo
Condicionamento Físico Animal
Substâncias Protetoras/isolamento & purificação
Estimulantes Históricos/isolamento & purificação
Natação/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Complex Mixtures); 0 (Protective Agents); 0 (Stimulants, Historical); 33X04XA5AT (Lactic Acid); 7664-41-7 (Ammonia); EC 3.1.3.1 (Alkaline Phosphatase)
[Em] Mês de entrada:1411
[Cu] Atualização por classe:140417
[Lr] Data última revisão:
140417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140418
[St] Status:MEDLINE
[do] DOI:10.3390/molecules19044669


  4 / 8 MEDLINE  
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[PMID]:24691065
[Au] Autor:Yeh TS; Huang CC; Chuang HL; Hsu MC
[Ad] Endereço:School of Nutrition and Health Sciences, Taipei Medical University, Taipei 11031, Taiwan.
[Ti] Título:Angelica sinensis improves exercise performance and protects against physical fatigue in trained mice.
[So] Source:Molecules;19(4):3926-39, 2014 Mar 31.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Angelica sinensis (AS) is a well-known medicinal herb and food material with antioxidative and multifunctional pharmacological activities. However, we lack evidence of the effect of AS on exercise performance and physical fatigue. We aimed to evaluate the potential beneficial effect of AS on ergogenic and anti-fatigue functions after physiological challenge. Male ICR strain mice were randomly assigned to four groups (n=10 per group) for treatment: (1) sedentary control and vehicle treatment (vehicle control); (2) exercise training with vehicle treatment (exercise control); (3) exercise training with AS treatment at 0.41 g/kg/day (Ex-AS1); and (4) 2.05 g/kg/day (Ex-AS5); both the vehicle and AS were orally administered for 6 weeks. Exercise performance and anti-fatigue function were evaluated by forelimb grip strength, exhaustive swimming time, and levels of serum lactate, ammonia, glucose, and creatine kinase (CK) after a 15-min swimming exercise. Trend analysis revealed that AS treatments significantly increased endurance swimming time and blood glucose level, and decreased serum lactate, ammonia and CK levels. Liver and muscle glycogen contents were higher for Ex-AS1 and Ex-AS5 groups than the exercise control. Therefore, AS supplementation improved exercise performance and had anti-fatigue properties in mice and may be an effective ergogenic aid in exercise training.
[Mh] Termos MeSH primário: Angelica sinensis/química
Fadiga/prevenção & controle
Esforço Físico/efeitos dos fármacos
Substâncias Protetoras/farmacologia
Estimulantes Históricos/farmacologia
[Mh] Termos MeSH secundário: Amônia/sangue
Animais
Glicemia/metabolismo
Creatina Quinase/sangue
Fadiga/sangue
Ácido Láctico/sangue
Fígado/efeitos dos fármacos
Fígado/metabolismo
Masculino
Camundongos
Camundongos Endogâmicos ICR
Força Muscular/efeitos dos fármacos
Músculo Esquelético/efeitos dos fármacos
Músculo Esquelético/metabolismo
Condicionamento Físico Animal
Extratos Vegetais/química
Substâncias Protetoras/isolamento & purificação
Estimulantes Históricos/isolamento & purificação
Natação/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Plant Extracts); 0 (Protective Agents); 0 (Stimulants, Historical); 33X04XA5AT (Lactic Acid); 7664-41-7 (Ammonia); EC 2.7.3.2 (Creatine Kinase)
[Em] Mês de entrada:1411
[Cu] Atualização por classe:140402
[Lr] Data última revisão:
140402
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140403
[St] Status:MEDLINE
[do] DOI:10.3390/molecules19043926


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[PMID]:24620483
[Au] Autor:Guly HR
[Ti] Título:Medical supplies for the expeditions of the heroic age of Antarctic exploration: oral medications.
[So] Source:Pharm Hist (Lond);42(4):72-7, 2012 Dec.
[Is] ISSN:0079-1393
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Equipamentos e Provisões/história
Expedições/história
Medicina Bucal/história
[Mh] Termos MeSH secundário: Regiões Antárticas
Clima Frio
Fármacos Gastrointestinais/classificação
Fármacos Gastrointestinais/história
História do Século XX
Seres Humanos
Ópio/classificação
Ópio/história
Medicina Bucal/classificação
Estimulantes Históricos/classificação
Estimulantes Históricos/história
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Gastrointestinal Agents); 0 (Stimulants, Historical); 8008-60-4 (Opium)
[Em] Mês de entrada:1404
[Cu] Atualização por classe:140313
[Lr] Data última revisão:
140313
[Sb] Subgrupo de revista:QIS
[Da] Data de entrada para processamento:140314
[St] Status:MEDLINE


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[PMID]:18756856
[Au] Autor:Adeneye AA; Agbaje EO; Elias SO; Amole OO
[Ad] Endereço:Department of Pharnncology, Faculty of Basic Medical Sciences, Lagos State University, College of Medicine, Ikeja, Nigeria. adeneye2001@yahoo.com
[Ti] Título:Oral toxicity studies of a Nigerian polyherbal health tonic tea extract in rats.
[So] Source:Afr J Med Med Sci;37(1):55-63, 2008 Mar.
[Is] ISSN:0309-3913
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:In the present study, acute and subchronic oral toxicity studies of an aqueous extract of a Nigerian Polyherbal Health Tonic (PHT) were investigated in adult Wistar rats of both sexes and weighing between 110-200 g. Acute toxicity study was conducted using limit dose test of Up and Down Procedure under computer guided statistical software program (AOT 425 StatPgm). The subchronic toxicity was evaluated in 4 groups of rats made up of six rats/group, administered single, daily oral doses of 10 ml/kg distilled water (DW), 125, 500 and 1500 mg/kg of PHT, respectively, for 90 days. On the 91st day, blood samples for haematological and biochemical assays were collected through cardiac puncture and selected vital organs harvested en bloc for histopathological examination under inhaled anaesthesia. Results showed PHT to be relatively safe on acute toxicity with an estimated LD50 value greater than 5000 mg/kg/oral route. On prolonged exposure, PHT induced initial weight gain in the 1st 6 weeks followed by significant (P < 0.05) dose related weight loss in the latter 6 weeks. The extract also caused significant (P < 0.05) dose related elevation of the full blood count parameters, dose unrelated elevation of serum urea, liver enzymes, serum proteins, albumin, total and conjugated bilirubin. On histology, PHT induced dose dependent gastric mucosal denudation, bile ductal lining distortion, diffuse pulmonary interstitial fibrous proliferation and diffuse splenic lymphocytic proliferation. Thus, our results showed that PHT use may be relatively safe on acute exposure but toxic on chronic exposure to high doses, although reversibility of these toxic effects was not studied in the present study.
[Mh] Termos MeSH primário: Medicina Tradicional Africana
Estimulantes Históricos/toxicidade
Chá/toxicidade
[Mh] Termos MeSH secundário: Administração Oral
Animais
Relação Dose-Resposta a Droga
Feminino
Masculino
Nigéria
Tamanho do Órgão/efeitos dos fármacos
Distribuição Aleatória
Ratos
Ratos Wistar
Testes de Toxicidade
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Stimulants, Historical); 0 (Tea)
[Em] Mês de entrada:0901
[Cu] Atualização por classe:080901
[Lr] Data última revisão:
080901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080902
[St] Status:MEDLINE


  7 / 8 MEDLINE  
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[PMID]:16306490
[Au] Autor:McCrory P
[Ti] Título:Last orders, gents...
[So] Source:Br J Sports Med;39(12):879, 2005 Dec.
[Is] ISSN:1473-0480
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Consumo de Bebidas Alcoólicas/história
Corrida/história
[Mh] Termos MeSH secundário: História do Século XX
Seres Humanos
Masculino
Corrida/fisiologia
Estimulantes Históricos/história
Estricnina/administração & dosagem
[Pt] Tipo de publicação:EDITORIAL; HISTORICAL ARTICLE
[Nm] Nome de substância:
0 (Stimulants, Historical); H9Y79VD43J (Strychnine)
[Em] Mês de entrada:0601
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:051125
[St] Status:MEDLINE


  8 / 8 MEDLINE  
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[PMID]:12941969
[Au] Autor:Ventegodt S; Merrick J
[Ad] Endereço:The Quality of Life Research Center, Copenhagen K, Denmark. ventegodt@livskvalitet.org
[Ti] Título:Psychoactive drugs and quality of life.
[So] Source:ScientificWorldJournal;3:694-706, 2003 Aug 18.
[Is] ISSN:1537-744X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study was performed on a representative sample of the Danish population in order to investigate the connection to the use of psychoactive drugs and quality of life (QOL) by way of a questionnaire-based survey. The questionnaire was mailed in February 1993 to 2,460 persons aged between 18 and 88, randomly selected from the CPR (Danish Central Register), and 7,222 persons from the Copenhagen Perinatal Birth Cohort 1959-61. A total of 1,501 persons between the ages 18 and 88 years and 4,626 persons between the ages 31 and 33 years returned the questionnaire (response rates of 61.0% and 64.1%, respectively). Variables investigated in this study were ten different psychotropic drugs and quality of life. Our study showed that over half the Danish population had used illegal psychotropic drugs. The most commonly used was cannabis (marijuana) though experience of this drug appeared not to co-vary with QOL to any significant extent. Cocaine, amphetamine, and psilocybin had been used by 1.2 to 3.3% of the population and this varied with QOL to a clear albeit small extent. LSD has been used by 1.2% of the population and the users had a QOL score 10% lower than those who had never used psychotropic drugs. The group with the lowest quality of life was found to be persons who had used heroin, morphine, methadone, and a mixture of alcohol and tranquilizers (10-20% below the group with the highest quality of life).
[Mh] Termos MeSH primário: Psicotrópicos/farmacologia
Qualidade de Vida
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Anfetaminas/farmacologia
Cocaína/farmacologia
Estudos de Coortes
Coleta de Dados/métodos
Coleta de Dados/tendências
Alucinógenos/farmacologia
Heroína/farmacologia
Seres Humanos
Abuso de Maconha/epidemiologia
Abuso de Maconha/psicologia
Metadona/farmacologia
Meia-Idade
Morfina/farmacologia
Estimulantes Históricos/farmacologia
Transtornos Relacionados ao Uso de Substâncias/epidemiologia
Transtornos Relacionados ao Uso de Substâncias/psicologia
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amphetamines); 0 (Hallucinogens); 0 (Psychotropic Drugs); 0 (Stimulants, Historical); 70D95007SX (Heroin); 76I7G6D29C (Morphine); I5Y540LHVR (Cocaine); UC6VBE7V1Z (Methadone)
[Em] Mês de entrada:0403
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:030828
[St] Status:MEDLINE



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