Base de dados : MEDLINE
Pesquisa : D27.720.031 [Categoria DeCS]
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[PMID]:29424213
[Au] Autor:Malysheva AG; Rakhmanin YA; Rastyannikov EG; Kozlova NY; Artyushina IY; Shokhin VA
[Ti] Título:[Gas chromatography-mass spectrometric studies of volatile emissions from plants for the assessment of the effectiveness and chemical safety of the implementation of environment improving phytotechnologies].
[So] Source:Gig Sanit;95(6):501-7, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The chromato-mass-spectrometric studies of volatile emissions of fresh-cut roses have revealed the persistence of wide range of organic compounds. The most large content was consist of terpene hydrocarbons. The contribution of oxygen-containing components (alcohols, ethers, aldehydes and ketones) varied in wide ranges in dependence on the content of the feeding solution. The significant part of plants ' volatiles has no hygienic norm. Among the substances released into the air space ofpremises with volatile emissions ofplants, a significant part has not hygienic standards. Purposeful change in composition of the mixture of volatile organic compounds released by the plants, in the combination with chemical-analytical control of the content of these substances by gas chromatography-mass spectrometry in terms of ecological and hygienic aspects may be useful in the development, use and determination of the optimal conditions of the implementation of environment improving phytotechnologies and evaluation of the efficacy and safety of their impact on public health.
[Mh] Termos MeSH primário: Agroquímicos
Exposição Ambiental
Cromatografia Gasosa-Espectrometria de Massas/métodos
Rosa
Compostos Orgânicos Voláteis
[Mh] Termos MeSH secundário: Agroquímicos/efeitos adversos
Agroquímicos/análise
Exposição Ambiental/análise
Exposição Ambiental/prevenção & controle
Monitoramento Ambiental/métodos
Fertilizantes/efeitos adversos
Fertilizantes/análise
Seres Humanos
Compostos Orgânicos/efeitos adversos
Compostos Orgânicos/análise
Federação Russa/epidemiologia
Compostos Orgânicos Voláteis/efeitos adversos
Compostos Orgânicos Voláteis/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Agrochemicals); 0 (Fertilizers); 0 (Organic Chemicals); 0 (Volatile Organic Compounds)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180210
[St] Status:MEDLINE


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[PMID]:29290106
[Au] Autor:Lv P; Chen Y; Zhao Z; Shi T; Wu X; Xue J; Li QX; Hua R
[Ad] Endereço:Key Laboratory of Agri-Food Safety of Anhui Province, School of Resource & Environment, Anhui Agricultural University , 130 Changjiangxi Road, Hefei, Anhui 230036, China.
[Ti] Título:Design, Synthesis, and Antifungal Activities of 3-Acyl Thiotetronic Acid Derivatives: New Fatty Acid Synthase Inhibitors.
[So] Source:J Agric Food Chem;66(4):1023-1032, 2018 Jan 31.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Emerging fungal phytodiseases are increasingly becoming a food security threat. Twenty-six new 3-acylthiotetronic acid derivatives were designed, synthesized, characterized, and evaluated for activities against Valsa mali, Curvularia lunata, Fusarium graminearum, and Fusarium oxysporum f. sp. lycopersici. Among the 26 compounds, 6f was the most effective against V. mali, C. lunata, F. graminearum, and F. oxysporum f. sp. lycopersici with median effective concentrations (EC ) of 4.1, 3.1, 3.6, and 4.1 µg/mL, respectively, while the corresponding EC were 0.14, 6.7, 22.4, and 4.3 µg/mL of the fungicide azoxystrobin; 4.2, 41.7, 0.42, and 0.12 µg/mL of the fungicide carbendazim; and >50, 0.19, 0.43, and BS > 50 µg/mL of the fungicide fluopyram. The inhibitory potency against V. mali fatty acid synthase agreed well with the in vitro antifungal activity. The molecular docking suggested that the 3-acylthiotetronic acid derivatives targeted the C171Q KasA complex. The findings help understanding the mode of action and design and synthesis of novel potent fungicides.
[Mh] Termos MeSH primário: Inibidores Enzimáticos
Ácido Graxo Sintases/antagonistas & inibidores
Fungicidas Industriais/síntese química
Fungicidas Industriais/farmacologia
Hidroxibutiratos/química
Compostos de Sulfidrila/química
[Mh] Termos MeSH secundário: Acilação
Agroquímicos
Ascomicetos/efeitos dos fármacos
Cristalografia por Raios X
Desenho de Drogas
Fungicidas Industriais/química
Fusarium/efeitos dos fármacos
Modelos Moleculares
Simulação de Acoplamento Molecular
Estrutura Molecular
Doenças das Plantas/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Agrochemicals); 0 (Enzyme Inhibitors); 0 (Fungicides, Industrial); 0 (Hydroxybutyrates); 0 (Sulfhydryl Compounds); 0 (thiotetronic acid); EC 2.3.1.85 (Fatty Acid Synthases)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180102
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b05491


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[PMID]:29281878
[Au] Autor:Mustafa IF; Hussein MZ; Saifullah B; Idris AS; Hilmi NHZ; Fakurazi S
[Ad] Endereço:Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology, Universiti Putra Malaysia , 43400 UPM Serdang, Selangor, Malaysia.
[Ti] Título:Synthesis of (Hexaconazole-Zinc/Aluminum-Layered Double Hydroxide Nanocomposite) Fungicide Nanodelivery System for Controlling Ganoderma Disease in Oil Palm.
[So] Source:J Agric Food Chem;66(4):806-813, 2018 Jan 31.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A fungicide, hexaconazole was successfully intercalated into the intergalleries of zinc/aluminum-layered double hydroxide (ZALDH) using the ion-exchange method. Due to the intercalation of hexaconazole, the basal spacing of the ZALDH was increased from 8.7 Å in ZALDH to 29.4 Å in hexaconazole-intercalated ZALDH (HZALDH). The intercalation of hexaconazole into the interlayer of the nanocomposite was confirmed using the Fourier-transform infrared (FTIR) study. This supramolecular chemistry intercalation process enhanced the thermal stability of the hexaconazole moiety. The fungicide loading was estimated to be 51.8%. The nanodelivery system also shows better inhibition toward the Ganoderma boninense growth than the counterpart, free hexaconazole. The results from this work have a great potential to be further explored for combating basal stem rot (BSR) disease in oil palm plantation.
[Mh] Termos MeSH primário: Arecaceae/microbiologia
Fungicidas Industriais/administração & dosagem
Ganoderma/efeitos dos fármacos
Nanocompostos/química
Doenças das Plantas/prevenção & controle
Triazóis/administração & dosagem
[Mh] Termos MeSH secundário: Agroquímicos/administração & dosagem
Alumínio/química
Preparações de Ação Retardada
Hidróxidos/química
Doenças das Plantas/microbiologia
Zinco/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Agrochemicals); 0 (Delayed-Action Preparations); 0 (Fungicides, Industrial); 0 (Hydroxides); 0 (Triazoles); CPD4NFA903 (Aluminum); J41CSQ7QDS (Zinc); SX9R3X1FQV (hexaconazole)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04222


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[PMID]:29185664
[Au] Autor:Staley ZR; Rohr JR; Senkbeil JK; Harwood VJ
[Ti] Título:Agrochemicals indirectly increase survival of E. coli O157:H7 and indicator bacteria by reducing ecosystem services.
[So] Source:Ecol Appl;24(8):1945-53, 2014.
[Is] ISSN:1051-0761
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Storm water and agricultural runoff frequently contain agrochemicals, fecal indicator bacteria (FIB), and zoonotic pathogens. Entry of such contaminants into aquatic ecosystems may affect ecology and human health. This study tested the hypothesis that the herbicide atrazine and the fungicide chlorothalonil indirectly affect the survival of FIB (Escherichia coli and Enterococcus faecalis) and a pathogen (E. coli O157:H7) by altering densities of protozoan predators or by altering competition from autochthonous bacteria. Streptomycin-resistant E. coli, En. faecalis, and E. coli O157:H7 were added to microcosms composed of Florida river water containing natural protozoan and bacterial populations. FIB, pathogen, and protozoan densities were monitored over six days. Known metabolic inhibitors, cycloheximide and streptomycin, were used to inhibit autochthonous protozoa or bacteria, respectively. The inhibitors made it possible to isolate the effects of predation or competition on survival of allochthonous bacteria, and each treatment increased the survival of FIB and pathogens. Chlorothalonil's effect was similar to that of cycloheximide, significantly reducing protozoan densities and elevating densities of FIB and pathogens relative to the control. Atrazine treatment did not affect protozoan densities, but, through an effect on competition, resulted in significantly greater densities of En. faecalis and E. coli O157:H7. Hence, by reducing predaceous protozoa and bacterial competitors that facilitate purifying water bodies of FIBs and human pathogens, chlorothalonil and atrazine indirectly diminished an ecosystem service of fresh water.
[Mh] Termos MeSH primário: Agroquímicos
Ecossistema
Escherichia coli O157/fisiologia
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Antifúngicos/química
Antifúngicos/farmacologia
Atrazina/química
Atrazina/farmacologia
Conservação dos Recursos Naturais
Cicloeximida/química
Cicloeximida/farmacologia
Enterococcus faecalis/fisiologia
Monitoramento Ambiental
Eucariotos/efeitos dos fármacos
Fungicidas Industriais/química
Fungicidas Industriais/farmacologia
Herbicidas/química
Herbicidas/farmacologia
Nitrilos/química
Nitrilos/farmacologia
Microbiologia da Água
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Agrochemicals); 0 (Antifungal Agents); 0 (Fungicides, Industrial); 0 (Herbicides); 0 (Nitriles); 0 (Water Pollutants, Chemical); 98600C0908 (Cycloheximide); J718M71A7A (tetrachloroisophthalonitrile); QJA9M5H4IM (Atrazine)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171221
[Lr] Data última revisão:
171221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE


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[PMID]:28934092
[Au] Autor:Engel LS; Werder E; Satagopan J; Blair A; Hoppin JA; Koutros S; Lerro CC; Sandler DP; Alavanja MC; Beane Freeman LE
[Ad] Endereço:Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina , Chapel Hill, North Carolina, USA.
[Ti] Título:Insecticide Use and Breast Cancer Risk among Farmers' Wives in the Agricultural Health Study.
[So] Source:Environ Health Perspect;125(9):097002, 2017 Sep 06.
[Is] ISSN:1552-9924
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Some epidemiologic and laboratory studies suggest that insecticides are related to increased breast cancer risk, but the evidence is inconsistent. Women engaged in agricultural work or who reside in agricultural areas may experience appreciable exposures to a wide range of insecticides. OBJECTIVE: We examined associations between insecticide use and breast cancer incidence among wives of pesticide applicators (farmers) in the prospective Agricultural Health Study. METHODS: Farmers and their wives provided information on insecticide use, demographics, and reproductive history at enrollment in 1993-1997 and in 5-y follow-up interviews. Cancer incidence was determined via cancer registries. Among 30,594 wives with no history of breast cancer before enrollment, we examined breast cancer risk in relation to the women's and their husbands' insecticide use using Cox proportional hazards regression to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). RESULTS: During an average 14.7-y follow-up, 39% of the women reported ever using insecticides, and 1,081 were diagnosed with breast cancer. Although ever use of insecticides overall was not associated with breast cancer risk, risk was elevated among women who had ever used the organophosphates chlorpyrifos [HR=1.4 (95% CI: 1.0, 2.0)] or terbufos [HR=1.5 (95% CI: 1.0, 2.1)], with nonsignificantly increased risks for coumaphos [HR=1.5 (95% CI: 0.9, 2.5)] and heptachlor [HR=1.5 (95% CI: 0.7, 2.9)]. Risk in relation to the wives' use was associated primarily with premenopausal breast cancer. We found little evidence of differential risk by tumor estrogen receptor status. Among women who did not apply pesticides, the husband's use of fonofos was associated with elevated risk, although no exposure-response trend was observed. CONCLUSION: Use of several organophosphate insecticides was associated with elevated breast cancer risk. However, associations for the women's and husbands' use of these insecticides showed limited concordance. Ongoing cohort follow-up may help clarify the relationship, if any, between individual insecticide exposures and breast cancer risk. https://doi.org/10.1289/EHP1295.
[Mh] Termos MeSH primário: Agroquímicos/metabolismo
Neoplasias da Mama/epidemiologia
Inseticidas/metabolismo
Exposição Ocupacional/estatística & dados numéricos
Organofosfatos/metabolismo
[Mh] Termos MeSH secundário: Adulto
Idoso
Agricultura
Agroquímicos/toxicidade
Fazendeiros
Feminino
Seres Humanos
Incidência
Inseticidas/toxicidade
Meia-Idade
Organofosfatos/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Agrochemicals); 0 (Insecticides); 0 (Organophosphates)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE
[do] DOI:10.1289/EHP1295


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[PMID]:28889778
[Au] Autor:Turkez H; Arslan ME; Ozdemir O
[Ad] Endereço:a Faculty of Science, Department of Molecular Biology and Genetics , Erzurum Technical University , Erzurum , Turkey.
[Ti] Título:Genotoxicity testing: progress and prospects for the next decade.
[So] Source:Expert Opin Drug Metab Toxicol;13(10):1089-1098, 2017 Oct.
[Is] ISSN:1744-7607
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Genotoxicity and mutagenicity analyses have a significant role in the identification of hazard effects of therapeutic drugs, cosmetics, agrochemicals, industrial compounds, food additives, natural toxins and nanomaterials for regulatory purposes. To evaluate mutagenicity or genotoxicity, different in vitro and in vivo methodologies exert various genotoxicological endpoints such as point mutations, changes in number and structure of chromosomes. Areas covered: This review covered the basics of genotoxicity and in vitro/in vivo methods for determining of genetic damages. The limitations that have arisen as a result of the common use of these methods were also discussed. Finally, the perspectives of further prospects on the use of genotoxicity testing and genotoxic mode of action were emphasized. Expert opinion: The solution of actual and practical problems of genetic toxicology is inarguably based on the understanding of DNA damage mechanisms at molecular, subcellular, cellular, organ, system and organism levels. Current strategies to investigate human health risks should be modified to increase their performance for more reliable results and also new techniques such as toxicogenomics, epigenomics and single cell approaches must be integrated into genetic safety evolutions. The explored new biomarkers by the omic techniques will provide forceful genotoxicity assessment to reduce the cancer risk.
[Mh] Termos MeSH primário: Testes de Mutagenicidade/métodos
Mutagênicos/toxicidade
Medição de Risco/métodos
[Mh] Termos MeSH secundário: Agroquímicos/toxicidade
Animais
Cosméticos/toxicidade
Dano ao DNA/efeitos dos fármacos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/diagnóstico
Epigenômica/métodos
Aditivos Alimentares/toxicidade
Seres Humanos
Testes de Mutagenicidade/tendências
Mutação Puntual
Toxicogenética/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Agrochemicals); 0 (Cosmetics); 0 (Food Additives); 0 (Mutagens)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170912
[St] Status:MEDLINE
[do] DOI:10.1080/17425255.2017.1375097


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[PMID]:28805053
[Au] Autor:Sleiman M; de Sainte Claire P; Richard C
[Ad] Endereço:Equipe Photochimie CNRS, UMR 6296, Institut de Chimie de Clermont-Ferrand (ICCF) , 63178 Aubière, France.
[Ti] Título:Heterogeneous Photochemistry of Agrochemicals at the Leaf Surface: A Case Study of Plant Activator Acibenzolar-S-methyl.
[So] Source:J Agric Food Chem;65(35):7653-7660, 2017 Sep 06.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The photoreactivity of plant activator benzo(1,2,3)thiadiazole-7-carbothioic acid S-methyl ester (BTH), commonly named acibenzolar-S-methyl, was studied on the surfaces of glass, paraffinic wax films, and apple leaves. Experiments were carried out in a solar simulator using pure and formulated BTH (BION). Surface photoproducts were identified using liquid chromatography coupled with electrospray ionization and high-resolution Orbitrap mass spectrometry, while volatile photoproducts were characterized using an online thermal desorption system coupled to a gas chromatography-mass spectrometry (GC-MS) system. Pure BTH degraded quickly on wax surfaces with a half-life of 5.0 ± 0.5 h, whereas photolysis of formulated BTH was 7 times slower (t = 36 ± 14 h). On the other hand, formulated BTH was found to photolyze quickly on detached apple leaves with a half-life of 2.8 h ± 0.4 h. This drastic difference in photoreactivity was attributed to the nature and spreading of the BTH deposit, as influenced by the surfactant and surface characteristics. Abiotic stress of irradiated apple leaf was also shown to produce OH radicals which might contribute to the enhanced photodegradability. Eight surface photoproducts were identified, whereas GC-MS analyses revealed the formation of gaseous dimethyl disulfide and methanethiol. The yield of dimethyl disulfide ranged between 1.5% and 12%, and a significant fraction of dimethyl disulfide produced was found to be absorbed by the leaf. This is the first study to report on the formation of volatile chemicals and OH radicals during agrochemical photolysis on plant surfaces. The developed experimental approach can provide valuable insights into the heterogeneous photoreactivity of sprayed agrochemicals and could help improve dissipation models.
[Mh] Termos MeSH primário: Agroquímicos/química
Malus/efeitos dos fármacos
Folhas de Planta/efeitos da radiação
Tiadiazóis/química
[Mh] Termos MeSH secundário: Cromatografia Gasosa-Espectrometria de Massas
Malus/efeitos da radiação
Fotoquímica
Fotólise
Folhas de Planta/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Agrochemicals); 0 (Thiadiazoles); BCW6119347 (S-methyl benzo(1,2,3)thiadiazole-7-carbothioate)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170815
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b02622


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[PMID]:28658739
[Au] Autor:Shabeer TPA; Jadhav M; Girame R; Hingmire S; Bhongale A; Pudale A; Banerjee K
[Ad] Endereço:National Referral Laboratory, ICAR-National Research Centre for Grapes, Pune, Maharashtra, India. Electronic address: shabsnrcg@gmail.com.
[Ti] Título:Targeted screening and safety evaluation of 276 agrochemical residues in raisins using buffered ethyl acetate extraction and liquid chromatography-tandem mass spectrometry analysis.
[So] Source:Chemosphere;184:1036-1042, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A buffered ethyl acetate extraction method was optimized and validated in raisin matrix to monitor 276 pesticides by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. The final method involved homogenization of raisinsalong with water 1:1 raisins: water followed by extraction using ethyl acetate (10 mL/10 g raisins homogenate in presence of 0.1 mL acetic acid, 0.5 g sodium acetate and 10 g sodium sulfate, and cleanup by dispersive solid phase extraction with primary secondary amine sorbent (25 mg/5 mL extract). 276 pesticides were estimated within 20 min of chromatographic run time by retention time dependent 'scheduled multiple reaction monitoring' (sMRM) by LC-MS/MS.The method was validated as per European guideline, DG-SANTE/11945/2015, at 2, 10, and 25 ng/g spiking levels where the method precision in terms of repeatability was <15% at 10 ng/g for 93.8% of the compounds. The Limit of quantification (LOQ) ranged between 0.01 and 10 ng/g with recoveries 70-120% with ≤20% RSD for 93.5% of compounds at regulatory default MRL of 10 ng/g. The matrix induced signal suppressions or enhancement were moderate (60-130% accuracy against solvent standard) for 85% compounds in white raisins and 67% compounds in black raisins. The method was successfully applied for screening of 94 market samples of raisins for the target analytes. The dietaryexposures calculated against the average concentrations detected were wellbelow the maximum permissible intake (MPI) values and the collected raisin samples were considered safe for human consumption without any acute toxicity hazard.
[Mh] Termos MeSH primário: Agroquímicos/análise
Monitoramento Ambiental/métodos
Resíduos de Praguicidas/análise
[Mh] Termos MeSH secundário: Acetatos
Cromatografia Líquida/métodos
Seres Humanos
Praguicidas/análise
Extração em Fase Sólida/métodos
Solventes/análise
Espectrometria de Massas em Tandem/métodos
Vitis
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Agrochemicals); 0 (Pesticide Residues); 0 (Pesticides); 0 (Solvents); 76845O8NMZ (ethyl acetate)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE


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[PMID]:28640811
[Au] Autor:Robinson A; Hesketh H; Lahive E; Horton AA; Svendsen C; Rortais A; Dorne JL; Baas J; Heard MS; Spurgeon DJ
[Ad] Endereço:Centre for Ecology and Hydrology, Wallingford, Oxon, United Kingdom.
[Ti] Título:Comparing bee species responses to chemical mixtures: Common response patterns?
[So] Source:PLoS One;12(6):e0176289, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pollinators in agricultural landscapes can be exposed to mixtures of pesticides and environmental pollutants. Existing mixture toxicity modelling approaches, such as the models of concentration addition and independent action and the mechanistic DEBtox framework have been previously shown as valuable tools for understanding and ultimately predicting joint toxicity. Here we apply these mixture models to investigate the potential to interpret the effects of semi-chronic binary mixture exposure for three bee species: Apis mellifera, Bombus terrestris and Osmia bicornis within potentiation and mixture toxicity experiments. In the potentiation studies, the effect of the insecticide dimethoate with added propiconazole fungicide and neonicotinoid insecticide clothianidin with added tau-fluvalinate pyrethroid acaricide showed no difference in toxicity compared to the single chemical alone. Clothianidin toxicity showed a small scale, but temporally conserved increase in exposure conducted in the presence of propiconazole, particularly for B. terrestris and O. bicornis, the latter showing a near three-fold increase in clothianidin toxicity in the presence of propiconazole. In the mixture toxicity studies, the dominant response patterns were of additivity, however, binary mixtures of clothianidin and dimethoate in A. mellifera, B. terrestris and male O. bicornis there was evidence of a predominant antagonistic interaction. Given the ubiquitous nature of exposures to multiple chemicals, there is an urgent need to consider mixture effects in pollinator risk assessments. Our analyses suggest that current models, particularly those that utilise time-series data, such as DEBtox, can be used to identify additivity as the dominant response pattern and also those examples of interactions, even when small-scale, that may need to be taken into account during risk assessment.
[Mh] Termos MeSH primário: Agroquímicos/farmacologia
Abelhas/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Abelhas/fisiologia
Sinergismo Farmacológico
Polinização
Especificidade da Espécie
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Agrochemicals)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0176289


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[PMID]:28554660
[Au] Autor:Iavicoli I; Leso V; Beezhold DH; Shvedova AA
[Ad] Endereço:Department of Public Health, Division of Occupational Medicine, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy. Electronic address: ivo.iavicoli@unina.it.
[Ti] Título:Nanotechnology in agriculture: Opportunities, toxicological implications, and occupational risks.
[So] Source:Toxicol Appl Pharmacol;329:96-111, 2017 Aug 15.
[Is] ISSN:1096-0333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nanotechnology has the potential to make a beneficial impact on several agricultural, forestry, and environmental challenges, such as urbanization, energy constraints, and sustainable use of resources. However, new environmental and human health hazards may emerge from nano-enhanced applications. This raises concerns for agricultural workers who may become primarily exposed to such xenobiotics during their job tasks. The aim of this review is to discuss promising solutions that nanotechnology may provide in agricultural activities, with a specific focus on critical aspects, challenging issues, and research needs for occupational risk assessment and management in this emerging field. Eco-toxicological aspects were not the focus of the review. Nano-fertilizers, (nano-sized nutrients, nano-coated fertilizers, or engineered metal-oxide or carbon-based nanomaterials per se), and nano-pesticides, (nano-formulations of traditional active ingredients or inorganic nanomaterials), may provide a targeted/controlled release of agrochemicals, aimed to obtain their fullest biological efficacy without over-dosage. Nano-sensors and nano-remediation methods may detect and remove environmental contaminants. However, limited knowledge concerning nanomaterial biosafety, adverse effects, fate, and acquired biological reactivity once dispersed into the environment, requires further scientific efforts to assess possible nano-agricultural risks. In this perspective, toxicological research should be aimed to define nanomaterial hazards and levels of exposure along the life-cycle of nano-enabled products, and to assess those physico-chemical features affecting nanomaterial toxicity, possible interactions with agro-system co-formulants, and stressors. Overall, this review highlights the importance to define adequate risk management strategies for workers, occupational safety practices and policies, as well as to develop a responsible regulatory consensus on nanotechnology in agriculture.
[Mh] Termos MeSH primário: Doenças dos Trabalhadores Agrícolas/etiologia
Agricultura/métodos
Agroquímicos/efeitos adversos
Fazendeiros
Nanopartículas/efeitos adversos
Nanotecnologia/métodos
Exposição Ocupacional/efeitos adversos
Saúde do Trabalhador
[Mh] Termos MeSH secundário: Doenças dos Trabalhadores Agrícolas/prevenção & controle
Animais
Difusão de Inovações
Monitoramento Ambiental/métodos
Seres Humanos
Exposição Ocupacional/prevenção & controle
Medição de Risco
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Agrochemicals)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170531
[St] Status:MEDLINE



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