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[PMID]:28464967
[Au] Autor:Adesanya AW; Morales MA; Walsh DB; Lavine LC; Lavine MD; Zhu F
[Ad] Endereço:Irrigated Agriculture Research and Extension Center,Washington State University,Prosser, WA 99350,USA.
[Ti] Título:Mechanisms of resistance to three mite growth inhibitors of Tetranychus urticae in hops.
[So] Source:Bull Entomol Res;108(1):23-34, 2018 Feb.
[Is] ISSN:1475-2670
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Mite growth inhibitors (MGIs), such as etoxazole and hexythiazox, are valuable IPM tools for Tetranychus urticae control in hops due to their unique mode of action and selectivity. Hence, it is necessary to standardize bioassay methods to evaluate the efficacy of MGIs, monitor resistance, and identify mechanisms underlying MGI resistance in the field. Here, we developed a three-tiered approach for evaluating ovicidal toxicity of MGIs to T. urticae, which simulated different MGI exposure scenarios in the field. The most effective bioassay method was direct exposure of T. urticae eggs to MGIs. With this method, four field-collected T. urticae populations showed low-to-moderate resistance to MGIs. Cross-resistance among MGIs and from MGIs to bifenazate and bifenthrin was detected. Besides target site insensitivity, enhanced cytochrome P450 and esterase activities also contribute to the MGI resistance in hop yard-collected T. urticae populations. Low-to-moderate MGI resistance in T. urticae populations may be mediated by multiple mechanisms. Positive selection pressure on the I1017F mutation is moderate in field-collected T. urticae populations. Further studies are required to identify metabolic detoxification genes that confer resistance to MGIs for precise resistance monitoring.
[Mh] Termos MeSH primário: Acaricidas
Tetranychidae
[Mh] Termos MeSH secundário: Animais
Feminino
Resistência a Inseticidas
Óvulo
Tetranychidae/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acaricides)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1017/S0007485317000414


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[PMID]:28844385
[Au] Autor:Huang X; Zhang B; Xu H
[Ad] Endereço:Research Institute of Pesticidal Design & Synthesis, College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi Province, China.
[Ti] Título:Synthesis of some monosaccharide-related ester derivatives as insecticidal and acaricidal agents.
[So] Source:Bioorg Med Chem Lett;27(18):4336-4340, 2017 09 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:To develop natural-product-based pesticidal agents, a series of monosaccharide-related ester derivatives (17a-q and 18a-f), glucose (xylose)-piperic acid/piperic acid-like conjugates, were synthesized. Three-dimensional structures of compounds 17b, 17g, 17h, and 17n were unambiguously determined by single-crystal X-ray diffraction. Especially compounds 18e and 18f exhibited the most potent insecticidal and acaricidal activities against Mythimna separata and Tetranychus cinnabarinus. Their structure-activity relationships were also discussed.
[Mh] Termos MeSH primário: Acaricidas/farmacologia
Ésteres/farmacologia
Inseticidas/farmacologia
Monossacarídeos/farmacologia
Mariposas/efeitos dos fármacos
Tetranychidae/efeitos dos fármacos
[Mh] Termos MeSH secundário: Acaricidas/síntese química
Acaricidas/química
Animais
Relação Dose-Resposta a Droga
Ésteres/síntese química
Ésteres/química
Inseticidas/síntese química
Inseticidas/química
Estrutura Molecular
Monossacarídeos/química
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acaricides); 0 (Esters); 0 (Insecticides); 0 (Monosaccharides)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170829
[St] Status:MEDLINE


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[PMID]:28760358
[Au] Autor:Gandhi PR; Jayaseelan C; Mary RR; Mathivanan D; Suseem SR
[Ad] Endereço:Division of Nanobiotechnology, Department of Zoology, Auxilium College (Autonomous), Gandhi Nagar, 632 006, Vellore District, Tamil Nadu, India.
[Ti] Título:Acaricidal, pediculicidal and larvicidal activity of synthesized ZnO nanoparticles using Momordica charantia leaf extract against blood feeding parasites.
[So] Source:Exp Parasitol;181:47-56, 2017 Oct.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of the present study was to evaluate the acaricidal, pediculicidal and larvicidal effect of synthesized zinc oxide nanoparticles (ZnO NPs) using Momordica charantia leaf extract against the larvae of Rhipicephalus (Boophilus) microplus, adult of Pediculus humanus capitis, and the larvae of Anopheles stephensi, Culex quinquefasciatus. The ZnO NPs were characterized by using UV, XRD, FTIR and SEM-EDX. The SEM image confirms that the synthesized nanoparticles were spherical in shape with a size of 21.32 nm. The results of GC-MS analysis indicates the presence of the major compound of Nonacosane (C H ) in the M. charantia leaf extract. Cattle tick, head lice and mosquito larvae were exposed to a varying concentrations of the synthesized ZnO NPs and M. charantia leaf extract for 24 h. Compared to the leaf aqueous extract, biosynthesized ZnO NPs showed higher toxicity against R. microplus, P. humanus capitis, An. stephensi, and Cx. Quinquefasciatus with the LC values of 6.87, 14.38, 5.42, and 4.87 mg/L, respectively. The findings revealed that synthesized ZnO NPs possess excellent anti-parasitic activity. These results suggest that the green synthesized ZnO NPs has the potential to be used as an ideal ecofriendly approach for the control of R. microplus, P. humanus capitis and the mosquito larvae of An. Stephensi and Cx. quinquefasciatus.
[Mh] Termos MeSH primário: Acaricidas/farmacologia
Culicidae/efeitos dos fármacos
Momordica charantia/química
Pediculus/efeitos dos fármacos
Rhipicephalus/efeitos dos fármacos
Óxido de Zinco/farmacologia
[Mh] Termos MeSH secundário: Acaricidas/isolamento & purificação
Animais
Anopheles/efeitos dos fármacos
Bioensaio
Criança
Pré-Escolar
Culex/efeitos dos fármacos
Relação Dose-Resposta a Droga
Feminino
Cromatografia Gasosa-Espectrometria de Massas
Seres Humanos
Larva/efeitos dos fármacos
Nanopartículas Metálicas/química
Nanopartículas Metálicas/ultraestrutura
Microscopia Eletrônica de Varredura
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
Folhas de Planta/química
Espectrometria por Raios X
Óxido de Zinco/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acaricides); 0 (Plant Extracts); SOI2LOH54Z (Zinc Oxide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170802
[St] Status:MEDLINE


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[PMID]:28686725
[Au] Autor:Locke B; Semberg E; Forsgren E; de Miranda JR
[Ad] Endereço:Department of Ecology, Swedish University of Agricultural Sciences, Uppsala, Sweden.
[Ti] Título:Persistence of subclinical deformed wing virus infections in honeybees following Varroa mite removal and a bee population turnover.
[So] Source:PLoS One;12(7):e0180910, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Deformed wing virus (DWV) is a lethal virus of honeybees (Apis mellifera) implicated in elevated colony mortality rates worldwide and facilitated through vector transmission by the ectoparasitic mite Varroa destructor. Clinical, symptomatic DWV infections are almost exclusively associated with high virus titres during pupal development, usually acquired through feeding by Varroa mites when reproducing on bee pupae. Control of the mite population, generally through acaricide treatment, is essential for breaking the DWV epidemic and minimizing colony losses. In this study, we evaluated the effectiveness of remedial mite control on clearing DWV from a colony. DWV titres in adult bees and pupae were monitored at 2 week intervals through summer and autumn in acaricide-treated and untreated colonies. The DWV titres in Apistan treated colonies was reduced 1000-fold relative to untreated colonies, which coincided with both the removal of mites and also a turnover of the bee population in the colony. This adult bee population turnover is probably more critical than previously realized for effective clearing of DWV infections. After this initial reduction, subclinical DWV titres persisted and even increased again gradually during autumn, demonstrating that alternative non-Varroa transmission routes can maintain the DWV titres at significant subclinical levels even after mite removal. The implications of these results for practical recommendations to mitigate deleterious subclinical DWV infections and improving honeybee health management are discussed.
[Mh] Termos MeSH primário: Acaricidas/farmacologia
Abelhas/virologia
Ectoparasitoses/prevenção & controle
Picornaviridae/efeitos dos fármacos
Controle de Ácaros e Carrapatos/métodos
Varroidae/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Abelhas/parasitologia
Vetores de Doenças
Ectoparasitoses/parasitologia
Ectoparasitoses/virologia
Picornaviridae/crescimento & desenvolvimento
Picornaviridae/patogenicidade
Pupa/parasitologia
Pupa/virologia
RNA Viral/genética
Estações do Ano
Varroidae/virologia
Carga Viral/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acaricides); 0 (RNA, Viral)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180910


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[PMID]:28679151
[Au] Autor:Hakme E; Lozano A; Gómez-Ramos MM; Hernando MD; Fernández-Alba AR
[Ad] Endereço:University of Almeria, Agrifood Campus of International Excellence (ceiA3), 04120, Almería, Spain.
[Ti] Título:Non-target evaluation of contaminants in honey bees and pollen samples by gas chromatography time-of-flight mass spectrometry.
[So] Source:Chemosphere;184:1310-1319, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This work presents a non-targeted screening approach for the detection and quantitation of contaminants in bees and pollen, collected from the same hive, by GC-EI-ToF-MS. It consists of a spectral library datasets search using a compound database followed by a manual investigation and analytical standard confirmation together with semi-quantitation purposes. Over 20% of the compounds found automatically by the library search could not be confirmed manually. This number of false positive detections was mainly a consequence of an inadequate ion ratio criterion (±30%), not considered in the automatic searching procedure. Eight compounds were detected in bees and pollen. They include insecticides/acaricides (chlorpyrifos, coumaphos, fluvalinate-tau, chlorfenvinphos, pyridaben, and propyl cresol) at a concentration range of 1-1207 µg kg , herbicides (oxyfluorfen) at a concentration range of 212-1773 µg kg and a growth regulator hormone (methoprene). Some compounds were detected only in pollen; such as herbicides (clomazone), insecticides/acaricides and fungicides used to control Varroa mites as benzylbenzoate, bufencarb, allethrin, permethrin, eugenol and cyprodinil. Additional compounds were detected only in bees: flamprop-methyl, 2-methylphenol (2-49 µg kg ) and naphthalene (1-23 µg kg ). The proposed method presents important advantages as it can avoid the use of an unachievable number of analytical standards considered target compounds "a priori" but not present in the analyzed samples.
[Mh] Termos MeSH primário: Abelhas/química
Monitoramento Ambiental/métodos
Poluentes Ambientais/análise
Pólen/química
Testes de Toxicidade/métodos
[Mh] Termos MeSH secundário: Acaricidas/análise
Animais
Cresóis
Fungicidas Industriais/análise
Cromatografia Gasosa-Espectrometria de Massas/métodos
Herbicidas/análise
Mel/análise
Inseticidas/análise
Nitrilos
Piretrinas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acaricides); 0 (Cresols); 0 (Environmental Pollutants); 0 (Fungicides, Industrial); 0 (Herbicides); 0 (Insecticides); 0 (Nitriles); 0 (Pyrethrins); 364G5G03VC (fluvalinate); GF3CGH8D7Z (cresol); YW84DH5I7U (2-cresol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE


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[PMID]:28639697
[Au] Autor:Eiden AL; Kaufman PE; Oi FM; Dark MJ; Bloomquist JR; Miller RJ
[Ad] Endereço:Department of Entomology and Nematology, University of Florida, Gainesville, FL, U.S.A.
[Ti] Título:Determination of metabolic resistance mechanisms in pyrethroid-resistant and fipronil-tolerant brown dog ticks.
[So] Source:Med Vet Entomol;31(3):243-251, 2017 Sep.
[Is] ISSN:1365-2915
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Rhipicephalus sanguineus (Latreille) (Ixodida: Ixodidae) is a three-host dog tick found worldwide that is able to complete its' entire lifecycle indoors. Options for the management of R. sanguineus are limited and its' control relies largely on only a few acaricidal active ingredients. Previous studies have confirmed permethrin resistance and fipronil tolerance in R. sanguineus populations, commonly conferred by metabolic detoxification or target site mutations. Herein, five strains of permethrin-resistant and three strains of fipronil-tolerant ticks were evaluated for metabolic resistance using synergists to block metabolic enzymes. Synergist studies were completed with triphenyl phosphate (TPP) for esterase inhibition, piperonyl butoxide (PBO) for cytochrome P450 inhibition, and diethyl maleate (DEM) for glutathione-S-transferase inhibition. Additionally, increased esterase activity was confirmed using gel electrophoresis. The most important metabolic detoxification mechanism in permethrin-resistant ticks was increased esterase activity, followed by increased cytochrome P450 activity. The inhibition of metabolic enzymes did not have a marked impact on fipronil-tolerant tick strains.
[Mh] Termos MeSH primário: Acaricidas/farmacologia
Resistência a Medicamentos
Permetrina/farmacologia
Pirazóis/farmacologia
Rhipicephalus sanguineus/metabolismo
[Mh] Termos MeSH secundário: Animais
Inativação Metabólica
Larva/efeitos dos fármacos
Larva/crescimento & desenvolvimento
Larva/metabolismo
Rhipicephalus sanguineus/efeitos dos fármacos
Rhipicephalus sanguineus/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acaricides); 0 (Pyrazoles); 509F88P9SZ (Permethrin); QGH063955F (fipronil)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.1111/mve.12240


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[PMID]:28530186
[Au] Autor:Avinash B; Venu R; Prasad TNVKV; Alpha Raj M; Srinivasa Rao K; Srilatha C
[Ad] Endereço:Department of Veterinary Parasitology, Sri Venkateswara Veterinary University, College of Veterinary Science, Tirupati-517502, Andhra Pradesh, India.
[Ti] Título:Synthesis and characterisation of neem leaf extract, 2, 3-dehydrosalanol and quercetin dihydrate mediated silver nano particles for therapeutic applications.
[So] Source:IET Nanobiotechnol;11(4):383-389, 2017 Jun.
[Is] ISSN:1751-8741
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The utility of green silver nanoparticles (AgNPs) in veterinary medicine is steadily increasing as they have many therapeutic applications against pathogens and arthropods of livestock. In this study, green AgNPs using neem (N-AgNPs), 2,3-dehydrosalanol (2,3-DHS-AgNPs) and quercetin dihydrate (QDH-AgNPs) were synthesised and characterised. Synthesised compounds were characterised by UV-Vis spectroscopy and the peak absorbance was recorded at 370 nm for neem extract. For N-AgNPs, 2,3-DHS-AgNPs and QDH-AgNPs, the maximum absorbance peaks were at 430, 230 and 220 nm, respectively. The FTIR analysis confirmed the synthesis of green AgNPs. The XRD pattern of N-AgNPs showed the peaks corresponding to whole spectra of 2 values ranging from 10-80. The relatively higher intensity of (111, 222) planes in face centred cubic crystalline structure supports the formation of synthesised AgNPs. In DLS analysis, the hydrodynamic diameter of neem leaf extract was found to be 259.8 nm, followed by 5.3, 6.7 and 261.8 nm for 2,3-DHS-AgNPs, N-AgNPs and QDH-AgNPs, respectively. Based on the transmission electron microscopy and scanning electron microscopy image analyses, confirmed the formation of N-AgNPs, 2,3-DHS-AgNPs and QDH-AgNPs. These eco-friendly phyto-AgNPs may be of use as an effective alternative to chemical control methods against the arthropods of livestock.
[Mh] Termos MeSH primário: Acaricidas/administração & dosagem
Azadirachta/química
Benzotiadiazinas/administração & dosagem
Nanopartículas Metálicas/administração & dosagem
Quercetina/administração & dosagem
Prata/administração & dosagem
[Mh] Termos MeSH secundário: Acaricidas/química
Benzotiadiazinas/química
Química Verde/métodos
Teste de Materiais
Nanopartículas Metálicas/química
Nanopartículas Metálicas/ultraestrutura
Tamanho da Partícula
Extratos Vegetais/administração & dosagem
Extratos Vegetais/química
Folhas de Planta/química
Quercetina/química
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acaricides); 0 (Benzothiadiazines); 0 (Plant Extracts); 3M4G523W1G (Silver); 9IKM0I5T1E (Quercetin); EZN4D2O31B (dehydrosanol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170523
[St] Status:MEDLINE
[do] DOI:10.1049/iet-nbt.2016.0095


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[PMID]:28486589
[Au] Autor:DeGrandi-Hoffman G; Ahumada F; Graham H
[Ad] Endereço:Carl Hayden Bee Research Center, USDA-ARS, 2000 East Allen Rd., Tucson, AZ 85719.
[Ti] Título:Are Dispersal Mechanisms Changing the Host-Parasite Relationship and Increasing the Virulence of Varroa destructor (Mesostigmata: Varroidae) in Managed Honey Bee (Hymenoptera: Apidae) Colonies?
[So] Source:Environ Entomol;46(4):737-746, 2017 08 01.
[Is] ISSN:1938-2936
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Varroa (Varroa destructor Anderson and Trueman) are a serious pest of European honey bees (Apis mellifera L.), and difficult to control in managed colonies. In our 11-mo longitudinal study, we applied multiple miticide treatments, yet mite numbers remained high and colony losses exceeded 55%. High mortality from varroa in managed apiaries is a departure from the effects of the mite in feral colonies where bees and varroa can coexist. Differences in mite survival strategies and dispersal mechanisms may be contributing factors. In feral colonies, mites can disperse through swarming. In managed apiaries, where swarming is reduced, mites disperse on foragers robbing or drifting from infested hives. Using a honey bee-varroa population model, we show that yearly swarming curtails varroa population growth, enabling colony survival for >5 yr. Without swarming, colonies collapsed by the third year. To disperse, varroa must attach to foragers that then enter other hives. We hypothesize that stress from parasitism and virus infection combined with effects that viruses have on cognitive function may contribute to forager drift and mite and virus dispersal. We also hypothesize that drifting foragers with mites can measurably increase mite populations. Simulations initialized with field data indicate that low levels of drifting foragers with mites can create sharp increases in mite populations in the fall and heavily infested colonies in the spring. We suggest new research directions to investigate factors leading to mite dispersal on foragers, and mite management strategies with consideration of varroa as a migratory pest.
[Mh] Termos MeSH primário: Distribuição Animal
Criação de Abelhas
Abelhas/parasitologia
Interações Hospedeiro-Parasita
Varroidae/fisiologia
[Mh] Termos MeSH secundário: Acaricidas/farmacologia
Animais
Abelhas/crescimento & desenvolvimento
Larva/crescimento & desenvolvimento
Larva/parasitologia
Estudos Longitudinais
Modelos Biológicos
Óvulo/crescimento & desenvolvimento
Óvulo/parasitologia
Dinâmica Populacional
Pupa/crescimento & desenvolvimento
Pupa/parasitologia
Varroidae/efeitos dos fármacos
Varroidae/patogenicidade
Varroidae/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Acaricides)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171126
[Lr] Data última revisão:
171126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170510
[St] Status:MEDLINE
[do] DOI:10.1093/ee/nvx077


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[PMID]:28444217
[Au] Autor:Herrick NJ; Cloyd RA
[Ad] Endereço:Department of Entomology, Kansas State University, Manhattan, KS 66506 (nherrick@ksu.edu; rcloyd@ksu.edu).
[Ti] Título:Direct and Indirect Effects of Pesticides on the Insidious Flower Bug (Hemiptera: Anthocoridae) Under Laboratory Conditions.
[So] Source:J Econ Entomol;110(3):931-940, 2017 Jun 01.
[Is] ISSN:1938-291X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Greenhouse producers are interested in integrating natural enemies along with pesticides to suppress western flower thrips, Frankliniella occidentalis (Pergande), populations. The insidious flower bug, Orius insidiosus (Say), is a commercially available natural enemy of western flower thrips. We conducted a series of laboratory experiments to determine the direct and indirect effects of 28 pesticides (insecticides, miticides, and fungicides), 4 pesticide mixtures, and 4 surfactants (36 total treatments plus a water control) on the adult O. insidiosus survival and predation on western flower thrips adults under laboratory conditions. The number of live and dead O. insidiosus adults was recorded after 24, 48, 72, and 96 h. The results of the study indicate that the fungicides (aluminum tris, azoxystrobin, fenhexamid, and kresoxim-methyl), insect growth regulators (azadirachtin, buprofezin, kinoprene, and pyriproxyfen), botanicals (Capsicum oleoresin extract, garlic oil, soybean oil; and rosemary, rosemary oil, peppermint oil, and cottonseed oil), and entomopathogenic fungi (Beauveria bassiana and Metarhizium anisopliae) were minimally directly harmful to adult O. insidiosus, with 80% to 100% adult survival. However, abamectin, spinosad, pyridalyl, chlorfenapyr, tau-fluvalinate, imidacloprid, dinotefuran, acetamiprid, and thiamethoxam directly affected O. insidiosus survival after 96 h (0-60% adult survival). The pesticide mixtures of abamectin + spinosad and chlorfenapyr + dinotefuran reduced adult survival (20% and 0%, respectively, after 48 h). Furthermore, the surfactants were not directly harmful to O. insidiosus adults. All western flower thrips adults were killed by the surviving adult O. insidiosus after 48 h, indicating no indirect effects of the pesticides on predation.
[Mh] Termos MeSH primário: Praguicidas/toxicidade
Tensoativos/toxicidade
[Mh] Termos MeSH secundário: Acaricidas/toxicidade
Animais
Feminino
Fungicidas Industriais/toxicidade
Heterópteros
Inseticidas/toxicidade
Masculino
Tisanópteros/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acaricides); 0 (Fungicides, Industrial); 0 (Insecticides); 0 (Pesticides); 0 (Surface-Active Agents)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE
[do] DOI:10.1093/jee/tox093


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[PMID]:28395754
[Au] Autor:Geurden T; Becskei C; Vatta AF; Slootmans N; von Reitzenstein M; King VL; Lin D; Rugg D
[Ad] Endereço:Zoetis, Veterinary Medicine Research and Development, Mercuriusstraat 20, B-1930 Zaventem, Belgium. Electronic address: thomas.geurden@zoetis.com.
[Ti] Título:Efficacy of a new spot-on formulation of selamectin plus sarolaner against four common tick species infesting cats in Europe.
[So] Source:Vet Parasitol;238 Suppl 1:S3-S7, 2017 Apr.
[Is] ISSN:1873-2550
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A single application of a new spot-on formulation of selamectin plus sarolaner (Stronghold Plus, Zoetis) was evaluated for efficacy against the most common tick species infesting cats in Europe. In each of the seven laboratory studies, 16 adult and purpose-bred cats were randomly allocated to one of two treatment groups based on pre-treatment tick counts. Weekly infestations with 50 unfed adult Ixodes ricinus (2 studies), Ixodes hexagonus (1 study), Dermacentor reticulatus (2 studies), or Rhipicephalus sanguineus (2 studies) were scheduled on Days -2, 5, 12, 19, 26 and 33. Cats were treated on Day 0 with the spot-on formulation at the minimum recommended label dose of 6.0mg selamectin and 1.0mg sarolaner per kg bodyweight or with a placebo. Ticks were counted 48h after treatment and after each re-infestation. No treatment-related adverse reactions were recorded in any of the studies. Geometric mean live tick counts were significantly (P≤0.0012) lower in the selamectin/sarolaner-treated group compared to the placebo-treated group at all time-points. Against I. ricinus and I. hexagonus, efficacy was ≥97.2% against existing infestations and ≥97.4% against weekly re-infestations for at least 5 weeks. Treatment was 100% effective against existing R. sanguineus infestations and was ≥95.8% for at least 4 weeks. Against D. reticulatus treatment resulted in ≥94.4% efficacy for at least 4 weeks. Thus, a single application of the new spot-on formulation of selamectin plus sarolaner at the minimum dose provides rapid treatment of existing infestations and is at least one month effective against re-infestation by all relevant European tick species in cats.
[Mh] Termos MeSH primário: Acaricidas/administração & dosagem
Doenças do Gato/tratamento farmacológico
Isoxazóis/administração & dosagem
Ivermectina/análogos & derivados
Controle de Ácaros e Carrapatos/normas
Infestações por Carrapato/veterinária
[Mh] Termos MeSH secundário: Administração Tópica
Animais
Gatos
Europa (Continente)
Feminino
Ivermectina/administração & dosagem
Masculino
Distribuição Aleatória
Infestações por Carrapato/tratamento farmacológico
Carrapatos
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acaricides); 0 (Isoxazoles); 70288-86-7 (Ivermectin); A2669OWX9N (selamectin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170418
[Lr] Data última revisão:
170418
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE



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