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[PMID]:29431945
[Au] Autor:Sinitskaya TA; Malinovskaya NN
[Ti] Título:[Toxicological-hygienic justification of the acceptable daily intake of acetamiprid].
[So] Source:Gig Sanit;95(11):1055-8, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Neonicotinoids are currently meaningful component of rotation schemes of insecticides of selective action in the system of integrated pest control, which have agricultural importance in many countries. The research results of the biological impact of acetamiprid (neonicotinoids) on the body of laboratory animals are given in the article. The study showed that the explored active substance is related to the moderately hazardous compounds (hazard category 3) in case of one-time per oral penetration. Acetamiprid has polytropic action in the case of chronic (12 months) oral entering the body of laboratory animals, it gives rise changes in functionality of the central nervous system, blood system, liver functioning. On the base of alterations of the studied indices there were established both the no-effect dose level (NOEL) and acceptable daily intake of acetamiprid for humans.
[Mh] Termos MeSH primário: Células Sanguíneas/efeitos dos fármacos
Sistema Nervoso Central/efeitos dos fármacos
Neonicotinoides
Envenenamento
[Mh] Termos MeSH secundário: Administração Oral
Animais
Comportamento Animal/efeitos dos fármacos
Modelos Animais de Doenças
Testes Hematológicos/métodos
Inseticidas/farmacologia
Inseticidas/toxicidade
Testes de Função Hepática/métodos
Concentração Máxima Permitida
Neonicotinoides/farmacologia
Neonicotinoides/toxicidade
Nível de Efeito Adverso não Observado
Órgãos em Risco
Envenenamento/sangue
Envenenamento/diagnóstico
Envenenamento/etiologia
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Neonicotinoids); 5HL5N372P0 (acetamiprid)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE


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[PMID]:29431932
[Au] Autor:Rakitsky VN; Sinitskaya TA; Gromova IP; Klimova NN; Vafina DA
[Ti] Título:[Hygienic regulation of neonicotinoids derivative in the soil].
[So] Source:Gig Sanit;95(11):1016-21, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:For the assurance of the safe regulations for the use in agriculture persistent in soil insecticide neonicotinoids derivative, studies have been executed to investigate its impact on the soil microbiocenosis and migration to the neighboring environment of the active ingredient of this pesticide and the preparation based on it. On the ground of obtained experimental data there were determined threshold doses for the following indices of the harmfulness: migration-water, translocation (transmission into plants) and general sanitary indices. There were established limiting indices of the harmfulness: translocation and migration-water indices. The maximum permissible concentration (MPC) of neonicotinoids derivative in the soil accounted for 0.5 mg/kg of the soil. This content of the pesticide in the soil prevents its accumulation in plants in concentrations exceeding the maximum permissible levels (MPLs), in food products, it fails both to give rise in its transition in groundwater above the MPL for water reservoirs and influence on the soil microbiocenosis and self-purification processes.
[Mh] Termos MeSH primário: Agricultura
Neonicotinoides
Poluentes do Solo
Poluição Química da Água/prevenção & controle
[Mh] Termos MeSH secundário: Agricultura/métodos
Agricultura/normas
Monitoramento Ambiental/métodos
Monitoramento Ambiental/normas
Seres Humanos
Inseticidas/análise
Inseticidas/química
Concentração Máxima Permitida
Neonicotinoides/análise
Neonicotinoides/química
Saúde Pública/métodos
Saúde Pública/normas
Federação Russa
Poluentes do Solo/análise
Poluentes do Solo/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Neonicotinoids); 0 (Soil Pollutants)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE


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[PMID]:29029382
[Au] Autor:Barbosa PRR; Oliveira MD; Barros EM; Michaud JP; Torres JB
[Ad] Endereço:Departamento de Agronomia-Entomologia, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, s/n, Dois Irmãos, Recife, PE 52171-900, Brazil. Electronic address: pagro05@hotmail.com.
[Ti] Título:Differential impacts of six insecticides on a mealybug and its coccinellid predator.
[So] Source:Ecotoxicol Environ Saf;147:963-971, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Broad-spectrum insecticides may disrupt biological control and cause pest resurgence due to their negative impacts on natural enemies. The preservation of sustainable pest control in agroecosystems requires parallel assessments of insecticide toxicity to target pests and their key natural enemies. In the present study, the leaf dipping method was used to evaluate the relative toxicity of six insecticides to the striped mealybug, Ferrisia dasylirii (Cockerell) (Hemiptera: Pseudococcidae) and its predator, Tenuisvalvae notata (Mulsant) (Coleoptera: Coccinellidae). Three neurotoxic insecticides, lambda-cyhalothrin, methidathion and thiamethoxam, caused complete mortality of both pest and predator when applied at their highest field rates. In contrast, lufenuron, pymetrozine and pyriproxyfen caused moderate mortality of third-instar mealybug nymphs, and exhibited low or no toxicity to either larvae or adults of the lady beetle. At field rates, lufenuron and pymetrozine had negligible effects on prey consumption, development or reproduction of T. notata, but adults failed to emerge from pupae when fourth instar larvae were exposed to pyriproxyfen. In addition, pyriproxyfen caused temporary sterility; T. notata females laid non-viable eggs for three days after exposure, but recovered egg fertility thereafter. Our results indicate that the three neurotoxic insecticides can potentially control F. dasylirii, but are hazardous to its natural predator. In contrast, lufenuron and pymetrozine appear compatible with T. notata, although they appear less effective against the mealybug. Although the acute toxicity of pyriproxyfen to T. notata was low, some pupal mortality and reduced egg fertility suggest that this material could impede the predator's numerical response to mealybug populations.
[Mh] Termos MeSH primário: Coleópteros/efeitos dos fármacos
Poluentes Ambientais/toxicidade
Hemípteros/efeitos dos fármacos
Inseticidas/toxicidade
Controle Biológico de Vetores
[Mh] Termos MeSH secundário: Animais
Brasil
Coleópteros/crescimento & desenvolvimento
Feminino
Gossypium/parasitologia
Hemípteros/crescimento & desenvolvimento
Inseticidas/farmacologia
Larva/efeitos dos fármacos
Larva/crescimento & desenvolvimento
Ninfa/efeitos dos fármacos
Ninfa/crescimento & desenvolvimento
Comportamento Predatório/efeitos dos fármacos
Pupa/efeitos dos fármacos
Pupa/crescimento & desenvolvimento
Reprodução/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Environmental Pollutants); 0 (Insecticides)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171015
[St] Status:MEDLINE


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[PMID]:28942278
[Au] Autor:Demirci Ö; Güven K; Asma D; Ögüt S; Ugurlu P
[Ad] Endereço:Science Faculty, Department of Biology, Dicle University, 21280, Turkey. Electronic address: ozdem22@gmail.com.
[Ti] Título:Effects of endosulfan, thiamethoxam, and indoxacarb in combination with atrazine on multi-biomarkers in Gammarus kischineffensis.
[So] Source:Ecotoxicol Environ Saf;147:749-758, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Studies addressing the toxicity of pesticides towards non-target organisms focus on the median lethal concentration and biochemical response of individual pesticides. However, when determining environmental risks, it is important to test the combined effects of pesticides, such as insecticides and herbicides, which are frequently used together in agricultural areas. Here we aimed to investigate the toxic effects of the combined use of the herbicide atrazine and the insecticides, endosulfan, indoxacarb, and thiamethoxam on Gammarus kischineffensis. To do this, we tested the activities of oxidative stress, detoxification, and neurotoxicity biomarkers. Compared to atrazine alone, we detected higher glutathione-S-transferase, catalase and superoxide dismutase activities (oxidative stress biomarkers) when atrazine was combined with either endosulfan or indoxacarb. However, higher IBR values were determined in organisms where pesticide mixtures were used according to individual use. Based on these results, mixtures of atrazine and other pesticides may cause synergistic effects and may be evidence of increased toxicity and oxidative stress.
[Mh] Termos MeSH primário: Anfípodes/efeitos dos fármacos
Monitoramento Ambiental/métodos
Herbicidas/toxicidade
Inseticidas/toxicidade
Poluentes do Solo/toxicidade
[Mh] Termos MeSH secundário: Anfípodes/enzimologia
Animais
Atrazina/toxicidade
Biomarcadores/análise
Relação Dose-Resposta a Droga
Sinergismo Farmacológico
Endossulfano/toxicidade
Dose Letal Mediana
Neonicotinoides/toxicidade
Nitrocompostos/toxicidade
Oxazinas/toxicidade
Estresse Oxidativo/efeitos dos fármacos
Tiazóis/toxicidade
Fatores de Tempo
Testes de Toxicidade Aguda
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Herbicides); 0 (Insecticides); 0 (Neonicotinoids); 0 (Nitro Compounds); 0 (Oxazines); 0 (Soil Pollutants); 0 (Thiazoles); 52H0D26MWR (indoxacarb); 747IC8B487 (thiamethoxam); OKA6A6ZD4K (Endosulfan); QJA9M5H4IM (Atrazine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170925
[St] Status:MEDLINE


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[PMID]:28457508
[Au] Autor:Kawakami Y; Fuke C; Fukasawa M; Ninomiya K; Ihama Y; Miyazaki T
[Ad] Endereço:Department of Legal Medicine, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa Prefecture 903-0215, Japan. Electronic address: k138731@eve.u-ryukyu.ac.jp.
[Ti] Título:An experimental study of postmortem decomposition of methomyl in blood.
[So] Source:Leg Med (Tokyo);25:36-42, 2017 Mar.
[Is] ISSN:1873-4162
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Methomyl (S-methyl-1-N-[(methylcarbamoyl)oxy]thioacetimidate) is a carbamate pesticide. It has been noted that in some cases of methomyl poisoning, methomyl is either not detected or detected only in low concentrations in the blood of the victims. However, in such cases, methomyl is detected at higher concentrations in the vitreous humor than in the blood. This indicates that methomyl in the blood is possibly decomposed after death. However, the reasons for this phenomenon have been unclear. We have previously reported that methomyl is decomposed to dimethyl disulfide (DMDS) in the livers and kidneys of pigs but not in their blood. In addition, in the field of forensic toxicology, it is known that some compounds are decomposed or produced by internal bacteria in biological samples after death. This indicates that there is a possibility that methomyl in blood may be decomposed by bacteria after death. The aim of this study was therefore to investigate whether methomyl in blood is decomposed by bacteria isolated from human stool. Our findings demonstrated that methomyl was decomposed in human stool homogenates, resulting in the generation of DMDS. In addition, it was observed that three bacterial species isolated from the stool homogenates, Bacillus cereus, Pseudomonas aeruginosa, and Bacillus sp., showed methomyl-decomposing activity. The results therefore indicated that one reason for the difficulty in detecting methomyl in postmortem blood from methomyl-poisoning victims is the decomposition of methomyl by internal bacteria such as B. cereus, P. aeruginosa, and Bacillus sp.
[Mh] Termos MeSH primário: Autopsia
Toxicologia Forense/métodos
Inseticidas/análise
Inseticidas/envenenamento
Metomil/análise
Metomil/envenenamento
[Mh] Termos MeSH secundário: Bacillus/isolamento & purificação
Bacillus/metabolismo
Cromatografia Líquida de Alta Pressão
Fezes/química
Seres Humanos
Pseudomonas aeruginosa/isolamento & purificação
Pseudomonas aeruginosa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 1NQ08HN02S (Methomyl)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:27774651
[Au] Autor:Alharbi HA; Alcorn J; Al-Mousa A; Giesy JP; Wiseman SB
[Ad] Endereço:Toxicology Centre, University of Saskatchewan, Saskatoon, SK, Canada.
[Ti] Título:Toxicokinetics and toxicodynamics of chlorpyrifos is altered in embryos of Japanese medaka exposed to oil sands process-affected water: evidence for inhibition of P-glycoprotein.
[So] Source:J Appl Toxicol;37(5):591-601, 2017 05.
[Is] ISSN:1099-1263
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Oil sands process-affected water (OSPW) is generated during extraction of bitumen in the surface mining oil sands industry in Alberta, Canada. Studies were performed in vitro by use of Caco-2 cells, and in vivo with larvae of Japanese medaka (Oryzias latipes) to determine if organic compounds from the aqueous phase of OSPW inhibit ATP binding cassette protein ABCB1 (permeability-glycoprotein, P-gp). Neutral and basic fractions of OSPW inhibited activity of P-gp in Caco-2 cells by 1.9- and 2.0-fold, respectively, while the acidic fraction had the least effect. The organophosphate pesticides chlorpyrifos (a substrate of P-gp) and malathion (not a substrate of P-gp), were used as model chemicals to investigate inhibition of P-gp in larvae. Co-exposure to chlorpyrifos and an extract of OSPW containing basic and neutral compounds reduced survival of larvae to 26.5% compared to survival of larvae exposed only to chlorpyrifos, which was 93.7%. However, co-exposure to malathion and the extract of OSPW did not cause acute lethality compared to exposure only to malathion. Accumulation and bioconcentration of chlorpyrifos, but not malathion, was greater in larvae co-exposed with the extract of OSPW. The terminal elimination half-life of chlorpyrifos in larvae exposed to chlorpyrifos in freshwater was 5 days compared with 11.3 days in larvae exposed to chlorpyrifos in OSPW. Results suggest that in non-acute exposures, basic and neutral organic compounds in the water-soluble fraction of OSPW inhibit activity of P-gp, which suggests that OSPW has the potential to cause adverse effects by chemosensitization. Copyright © 2016 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Membro 1 da Subfamília B de Cassetes de Ligação de ATP/antagonistas & inibidores
Clorpirifos/toxicidade
Inseticidas/toxicidade
Campos de Petróleo e Gás
Oryzias/fisiologia
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Subfamília B de Transportador de Cassetes de Ligação de ATP/metabolismo
Alberta
Animais
Carga Corporal (Radioterapia)
Células CACO-2
Sobrevivência Celular/efeitos dos fármacos
Clorpirifos/farmacocinética
Embrião não Mamífero
Água Doce
Meia-Vida
Seres Humanos
Inseticidas/farmacocinética
Larva
Malation/toxicidade
Oryzias/metabolismo
Análise de Sobrevida
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (ABCB1 protein, human); 0 (ATP Binding Cassette Transporter, Sub-Family B); 0 (ATP-Binding Cassette, Sub-Family B, Member 1); 0 (Insecticides); 0 (Water Pollutants, Chemical); JCS58I644W (Chlorpyrifos); U5N7SU872W (Malathion)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1002/jat.3397


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[PMID]:29413583
[Au] Autor:Cao X; Jiang Z; Wang S; Hong S; Li H; Zhang C; Shao Y; She Y; Jin F; Jin M; Wang J
[Ad] Endereço:Key Laboratory of Agri-food Safety and Quality, Institute of Quality Standard and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Ministry of Agriculture of China, Beijing, 100081, PR China.
[Ti] Título:Metal-organic framework UiO-66 for rapid dispersive solid phase extraction of neonicotinoid insecticides in water samples.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1077-1078:92-97, 2018 Mar 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:UIO-66 crystals were explored for the first time to adsorb neonicotinoid insecticides in environmental water samples. HPLC coupled with tandem MS was used for quantification and determination of neonicotinoid insecticides. UiO-66 crystals was successfully synthesized by a simple constant-temperature bath method. Synthesized UiO-66 was characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), thermogravimetry and nitrogen adsorption porosimetry (NAP), which demonstrated a uniform particle size, a large Brunauer-Emmett-Teller (BET) surface area and high thermostability. The adsorbing results showed that UIO-66 crystals could be used as a promising adsorbents for rapid extraction of neonicotinoid insecticides and be reused at least 10 times. Under the optimized conditions, the limits of detection (LODs, S/N = 3) and limits of quantification (LOQs, S/N = 10) for the five insecticides were found to be 0.02-0.4 ng/mL and 0.05-1.0 ng/mL, respectively. This developed approach not only provided more simple and sensitive method, as well as possessing satisfactory recovery for neonicotinoid insecticides, but also for other traces in environmental samples.
[Mh] Termos MeSH primário: Inseticidas/isolamento & purificação
Estruturas Metalorgânicas/química
Neonicotinoides/isolamento & purificação
Extração em Fase Sólida/métodos
Poluentes Químicos da Água/isolamento & purificação
[Mh] Termos MeSH secundário: Adsorção
Água Potável/química
Concentração de Íons de Hidrogênio
Inseticidas/análise
Inseticidas/química
Lagos/química
Limite de Detecção
Modelos Lineares
Neonicotinoides/análise
Neonicotinoides/química
Concentração Osmolar
Reprodutibilidade dos Testes
Poluentes Químicos da Água/análise
Poluentes Químicos da Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drinking Water); 0 (Insecticides); 0 (Metal-Organic Frameworks); 0 (Neonicotinoids); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180208
[St] Status:MEDLINE


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[PMID]:29220516
[Au] Autor:Depalo L; Lanzoni A; Masetti A; Pasqualini E; Burgio G
[Ad] Endereço:Dipartimento di Scienze Agrarie-Entomologia, Alma Mater Studiorum-Università di Bologna, Italy.
[Ti] Título:Lethal and Sub-lethal Effects of Four Insecticides on the Aphidophagous Coccinellid Adalia bipunctata (Coleoptera: Coccinellidae).
[So] Source:J Econ Entomol;110(6):2662-2671, 2017 12 05.
[Is] ISSN:1938-291X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Conventional insecticide assays, which measure the effects of insecticide exposure on short-term mortality, overlook important traits, including persistence of toxicity or sub-lethal effects. Therefore, such approaches are especially inadequate for prediction of the overall impact of insecticides on beneficial arthropods. In this study, the side effects of four modern insecticides (chlorantraniliprole, emamectin benzoate, spinosad, and spirotetramat) on Adalia bipunctata (L.) (Coleoptera: Coccinellidae) were evaluated under laboratory conditions by exposition on treated potted plants. In addition to investigation of acute toxicity and persistence of harmful activity in both larvae and adults of A. bipunctata, demographic parameters were evaluated, to provide a comprehensive picture of the nontarget effects of these products. Field doses of the four insecticides caused detrimental effects to A. bipunctata; but in different ways. Overall, spinosad showed the best toxicological profile among the products tested. Emamectin benzoate could be considered a low-risk insecticide, but had high persistence. Chlorantraniliprole exhibited lethal effects on early instar larvae and adults, along with a long-lasting activity, instead spirotetramat showed a low impact on larval and adult mortality and can be considered a short-lived insecticide. However, demographic analysis demonstrated that chlorantraniliprole and spirotetramat caused sub-lethal effects. Our findings highlight that sole assessment of mortality can lead to underestimation of the full impact of pesticides on nontarget insects. Demographic analysis was demonstrated to be a sensitive method for detection of the sub-lethal effects of insecticides on A. bipunctata, and this approach should be considered for evaluation of insecticide selectivity.
[Mh] Termos MeSH primário: Coleópteros/efeitos dos fármacos
Inseticidas/toxicidade
[Mh] Termos MeSH secundário: Animais
Compostos Aza/toxicidade
Coleópteros/crescimento & desenvolvimento
Combinação de Medicamentos
Ivermectina/análogos & derivados
Ivermectina/toxicidade
Larva/efeitos dos fármacos
Larva/crescimento & desenvolvimento
Macrolídeos/toxicidade
Compostos de Espiro/toxicidade
ortoaminobenzoatos/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Aza Compounds); 0 (Drug Combinations); 0 (Insecticides); 0 (Macrolides); 0 (Spiro Compounds); 0 (ortho-Aminobenzoates); 4G7KR034OX (spirotetramat); 622AK9DH9G (chlorantranilipole); 70288-86-7 (Ivermectin); HVM3G4A01W (emamectin benzoate); XPA88EAP6V (spinosad)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE
[do] DOI:10.1093/jee/tox243


  9 / 38154 MEDLINE  
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[PMID]:29247934
[Au] Autor:Tang G; Yao J; Zhang X; Lu N; Zhu KY
[Ad] Endereço:College of Forestry, Northwest A&F University, Yangling, Shaanxi, 712100, China; Department of Entomology, Kansas State University, Manhattan, KS 66506, USA.
[Ti] Título:Comparison of gene expression profiles in the aquatic midge (Chironomus tentans) larvae exposed to two major agricultural pesticides.
[So] Source:Chemosphere;194:745-754, 2018 Mar.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We developed a high-resolution expression microarray based on 2456 unique transcripts from a cDNA library of the aquatic midge (Chironomus tentans). By using the microarray, we detected that 146, 434 and 243 genes were differentially expressed after C. tentans larvae were exposed to chlorpyrifos (organophosphate insecticide) at 0.1 and 0.5 µg/L, and atrazine (triazine herbicide) at 1000 µg/L, respectively, for 48 h. The number of differentially expressed genes in the larvae exposed to chlorpyrifos at 0.5 µg/L was three times of that in the larvae exposed to chlorpyrifos at 0.1 µg/L. Among the differentially expressed genes in response to chlorpyrifos exposures, 76 genes showed significant Blast hits, and among them 42 were in common between the chlorpyrifos and atrazine exposures. In 19 differentially expressed xenobiotic detoxification genes, 16 were significantly up-regulated in the larvae exposed to chlorpyrifos and/or atrazine. Two cytochrome P450 genes (CtCYP6EV1 and CtCYP4DG2) were specifically up-regulated by chlorpyrifos, whereas three cytochrome P450 genes (CtCYP4DG1, CtCYP6EX3 and CtCYP6EV3) were specifically up-regulated by atrazine. Our results showed that chlorpyrifos exposures even at low concentrations can lead to significant changes in gene expression. The significant transcriptional responses are likely attributed to larval intoxication by the insecticide. These results not only support our previous studies in which candidate gene approaches were used, but also can potentially help develop specific molecular markers for monitoring pesticide exposures in non-target organisms in aquatic systems.
[Mh] Termos MeSH primário: Chironomidae/genética
Larva/genética
Praguicidas/farmacologia
Transcriptoma/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Atrazina/farmacologia
Clorpirifos/farmacologia
Sistema Enzimático do Citocromo P-450/efeitos dos fármacos
Sistema Enzimático do Citocromo P-450/genética
Herbicidas/metabolismo
Inseticidas/metabolismo
Larva/efeitos dos fármacos
Larva/metabolismo
Praguicidas/metabolismo
Regulação para Cima/efeitos dos fármacos
Poluentes Químicos da Água/farmacologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Herbicides); 0 (Insecticides); 0 (Pesticides); 0 (Water Pollutants, Chemical); 9035-51-2 (Cytochrome P-450 Enzyme System); JCS58I644W (Chlorpyrifos); QJA9M5H4IM (Atrazine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE


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[PMID]:29360866
[Au] Autor:Cui B; Wang C; Zhao X; Yao J; Zeng Z; Wang Y; Sun C; Liu G; Cui H
[Ad] Endereço:Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China.
[Ti] Título:Characterization and evaluation of avermectin solid nanodispersion prepared by microprecipitation and lyophilisation techniques.
[So] Source:PLoS One;13(1):e0191742, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Poorly water-soluble and photosensitive pesticide compounds are difficult to formulate as solvent-free nanoformulations with high efficacy. A avermectin solid nanodispersion with a mean particle size of 188 nm was developed by microprecipitation and lyophilisation techniques. The suspensibility and wetting time of the solid nanodispersion in water were 99.8% and 13 s, respectively, superior to those of conventional water dispersible granules and wettable powders. The anti-photolysis performance of the nanoformulation was twice that of the technical material, and the biological activity against diamondback moths was more than 1.5 times that of the conventional solid formulations while taking LC 50 as the evaluation index. Moreover, the formulation composition substantially decreased the surfactant content and avoided organic solvents. Microprecipitation combined with lyophilisation is an easy and promising method to construct solid nanoformulations for pesticides with poor water solubility and environmental sensitivity. The application of the highly effective solid nanodispersion in crop production will have a great potential in reducing chemical residues and environmental pollution.
[Mh] Termos MeSH primário: Inseticidas/química
Ivermectina/análogos & derivados
[Mh] Termos MeSH secundário: Bioensaio
Liofilização
Ivermectina/química
Nanotecnologia
Solubilidade
Água/química
Molhabilidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Insecticides); 059QF0KO0R (Water); 70288-86-7 (Ivermectin); 73989-17-0 (avermectin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180124
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191742



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