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[PMID]:29343296
[Au] Autor:Seljetun KO; Eliassen E; Karinen R; Moe L; Vindenes V
[Ad] Endereço:Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences (NMBU), P.O. Box 8146 Dep, 0033, Oslo, Norway. kristin.opdal.seljetun@nmbu.no.
[Ti] Título:Quantitative method for analysis of six anticoagulant rodenticides in faeces, applied in a case with repeated samples from a dog.
[So] Source:Acta Vet Scand;60(1):3, 2018 Jan 17.
[Is] ISSN:1751-0147
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Accidental poisoning with anticoagulant rodenticides is not uncommon in dogs, but few reports of the elimination kinetics and half-lives in this species have been published. Our objectives were to develop and validate a new method for the quantification of anticoagulant rodenticides in canine blood and faeces using reversed phase ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) and apply the method on a case of anticoagulant rodenticide intoxication. RESULTS: Sample preparation was liquid-liquid extraction. Six anticoagulant rodenticides were separated using a UPLC BEH C -column with a mobile phase consisting of 5 mM ammonium formate buffer pH 10.2 and methanol. MS/MS detection was performed with positive electrospray ionization and two multiple reaction monitoring transitions. The limits of quantification were set at the levels of the lowest calibrator (1.5-2.7 ng/mL or ng/g). The method was successfully applied to a case from a dog accidentally poisoned with anticoagulant rodenticide. Coumatetralyl and brodifacoum concentrations were determined from serial blood and faecal samples. A terminal half-life of at least 81 days for coumatetralyl in blood was estimated, which is longer than previous reported in other species. A slow elimination of brodifacoum from the faeces was found, with traces still detectable in the faeces at day 513. CONCLUSIONS: This study offers a new method of detection and quantification of six frequently used anticoagulant rodenticides in canine faeces. Such drugs might cause serious health effects and it is important to be able to detect these drugs, to initiate proper treatment. The very long elimination half-lives detected in our study is important to be aware of in assessment of anticoagulant rodenticide burden to the environment.
[Mh] Termos MeSH primário: Técnicas de Química Analítica/métodos
Fezes/química
Rodenticidas/análise
Rodenticidas/envenenamento
[Mh] Termos MeSH secundário: Animais
Anticoagulantes/análise
Anticoagulantes/sangue
Anticoagulantes/envenenamento
Técnicas de Química Analítica/normas
Cromatografia Líquida de Alta Pressão
Cães
Meia-Vida
Limite de Detecção
Rodenticidas/sangue
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Anticoagulants); 0 (Rodenticides)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180119
[St] Status:MEDLINE
[do] DOI:10.1186/s13028-018-0357-9


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[PMID]:28456301
[Au] Autor:Lefebvre S; Hascoët C; Damin-Pernik M; Rannou B; Benoit E; Lattard V
[Ad] Endereço:USC 1233 INRA-Vetagro Sup, Veterinary School of Lyon, 1 Avenue Bourgelat, 69280 Marcy l'Etoile, France.
[Ti] Título:Monitoring of antivitamin K-dependent anticoagulation in rodents - Towards an evolution of the methodology to detect resistance in rodents.
[So] Source:Pestic Biochem Physiol;138:29-36, 2017 May.
[Is] ISSN:1095-9939
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Vitamin K antagonists are used as rodenticides for pest control management. In rodents, prothrombin time is used to monitor their effect despite its limits and the emergence of many coagulation methods. The aim of this study is to explore different coagulation monitoring methods in order to propose the best method and the best parameter to monitor vitamin K antagonists effect in rodents. The coagulation function was thus monitored with global coagulation assays and specialty assays after difethialone administration in rats. Despite many parameters obtained by thromboelastometry, only clotting time and clot formation time obtained by ExTEM were modified. Their evolution was fast with doubling time respectively of 4.0h and 3.7h but their increases were delayed with a lag time higher than 8h. Conversely, prothrombin time evolution presented a lag time of only 2h, but a higher doubling time of 7.2h. The measurements of factor VII and X activities were the most sensitive assays to monitor vitamin K antagonists effect with almost no lag time and the fastest evolution. Nevertheless, factor X was shown to be the only key factor driving prothrombin time. Monitoring factor X activity enables to follow most effectively the anticoagulation status in rats after rodenticides administration.
[Mh] Termos MeSH primário: 4-Hidroxicumarinas/farmacologia
Anticoagulantes/farmacologia
Vitamina K/metabolismo
[Mh] Termos MeSH secundário: Ração Animal
Animais
Coagulação Sanguínea/efeitos dos fármacos
Coagulação Sanguínea/genética
Fatores de Coagulação Sanguínea/metabolismo
Resistência a Medicamentos
Imunidade Inata
Fígado
Masculino
Ratos
Ratos Sprague-Dawley
Roedores
Rodenticidas
Vitamina K/antagonistas & inibidores
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (4-Hydroxycoumarins); 0 (Anticoagulants); 0 (Blood Coagulation Factors); 0 (Rodenticides); 12001-79-5 (Vitamin K); KOL4VXI5O0 (difethialone)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


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[PMID]:28886097
[Au] Autor:Desvars-Larrive A; Pascal M; Gasqui P; Cosson JF; Benoît E; Lattard V; Crespin L; Lorvelec O; Pisanu B; Teynié A; Vayssier-Taussat M; Bonnet S; Marianneau P; Lacôte S; Bourhy P; Berny P; Pavio N; Le Poder S; Gilot-Fromont E; Jourdain E; Hammed A; Fourel I; Chikh F; Vourc'h G
[Ad] Endereço:Conservation Medicine, Research Institute of Wildlife Ecology, University of Veterinary Medicine, Vienna, Austria.
[Ti] Título:Population genetics, community of parasites, and resistance to rodenticides in an urban brown rat (Rattus norvegicus) population.
[So] Source:PLoS One;12(9):e0184015, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Brown rats are one of the most widespread urban species worldwide. Despite the nuisances they induce and their potential role as a zoonotic reservoir, knowledge on urban rat populations remains scarce. The main purpose of this study was to characterize an urban brown rat population from Chanteraines park (Hauts-de-Seine, France), with regards to haematology, population genetics, immunogenic diversity, resistance to anticoagulant rodenticides, and community of parasites. Haematological parameters were measured. Population genetics was investigated using 13 unlinked microsatellite loci. Immunogenic diversity was assessed for Mhc-Drb. Frequency of the Y139F mutation (conferring resistance to rodenticides) and two linked microsatellites were studied, concurrently with the presence of anticoagulant residues in the liver. Combination of microscopy and molecular methods were used to investigate the occurrence of 25 parasites. Statistical approaches were used to explore multiple parasite relationships and model parasite occurrence. Eighty-six rats were caught. The first haematological data for a wild urban R. norvegicus population was reported. Genetic results suggested high genetic diversity and connectivity between Chanteraines rats and surrounding population(s). We found a high prevalence (55.8%) of the mutation Y139F and presence of rodenticide residues in 47.7% of the sampled individuals. The parasite species richness was high (16). Seven potential zoonotic pathogens were identified, together with a surprisingly high diversity of Leptospira species (4). Chanteraines rat population is not closed, allowing gene flow and making eradication programs challenging, particularly because rodenticide resistance is highly prevalent. Parasitological results showed that co-infection is more a rule than an exception. Furthermore, the presence of several potential zoonotic pathogens, of which four Leptospira species, in this urban rat population raised its role in the maintenance and spread of these pathogens. Our findings should stimulate future discussions about the development of a long-term rat-control management program in Chanteraines urban park.
[Mh] Termos MeSH primário: Resistência a Medicamentos
Genética Populacional
Parasitos
Rodenticidas/farmacologia
[Mh] Termos MeSH secundário: Animais
Biodiversidade
Biomarcadores
Contagem de Células Sanguíneas
França
Variação Genética
Genótipo
Geografia
Fenômenos Imunogenéticos
Repetições de Microssatélites
Parasitos/classificação
Parasitos/genética
Ratos
Saúde da População Urbana
Vitamina K Epóxido Redutases/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Rodenticides); EC 1.17.4.4 (VKORC1 protein, rat); EC 1.17.4.4 (Vitamin K Epoxide Reductases)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184015


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[PMID]:28699743
[Au] Autor:Smith LL; Liang B; Booth MC; Filigenzi MS; Tkachenko A; Gaskill CL
[Ad] Endereço:University of Kentucky Veterinary Diagnostic Laboratory, Toxicology Laboratory, University of Kentucky , Lexington, Kentucky 40511, United States.
[Ti] Título:Development and Validation of Quantitative Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry Assay for Anticoagulant Rodenticides in Liver.
[So] Source:J Agric Food Chem;65(31):6682-6691, 2017 Aug 09.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Anticoagulant rodenticides (ARs) are used to control rodent populations; however, exposure to nontarget animals occurs. A sensitive and rugged quantitative method was developed, optimized, and validated for eight ARs in liver. Target analytes comprised two chemical classes: hydroxycoumarins (warfarin, coumachlor, dicoumarol, bromadiolone, brodifacoum, and difethialone) and indanediones (diphacinone and chlorophacinone). In this method, liver extracts were cleaned using dispersive solid phase extraction (d-SPE) to remove matrix interferences and analyzed by reverse phase ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Electrospray ionization in negative ion mode combined with multiple reaction monitoring (MRM) using a triple quadrupole mass spectrometer provided simultaneous confirmation and quantitation. Detection limits spanned 0.75-25 ng/g, and lower quantitation limits were established as 50 ng/g. Interassay method accuracy ranged from 92 to 110% across the analytical range (50-2500 ng/g) using matrix-matched calibrants with good repeatability (relative standard deviations 2-16%). Successful method transfer to another laboratory utilizing an Orbitrap mass analyzer, providing high mass accuracy, was assessed by good method reproducibility during blinded study analyses (6-29%; Horwitz ratios (HORRAT) ≤ 1.5).
[Mh] Termos MeSH primário: Anticoagulantes/análise
Anticoagulantes/farmacologia
Cromatografia Líquida de Alta Pressão/métodos
Fígado/efeitos dos fármacos
Rodenticidas/análise
Rodenticidas/farmacologia
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Animais
Cavalos
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticoagulants); 0 (Rodenticides)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b02280


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[PMID]:28535134
[Au] Autor:Lawson C; O'Brien M; McMichael M
[Ad] Endereço:From the University of Illinois, Urbana, Illinois.
[Ti] Título:Upper Airway Obstruction Secondary to Anticoagulant Rodenticide Toxicosis in Five Dogs.
[So] Source:J Am Anim Hosp Assoc;53(4):236-241, 2017 Jul/Aug.
[Is] ISSN:0587-2871
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Five dogs were presented with clinical signs compatible with upper airway obstruction, including stridor, stertor, coughing, gagging, and varying degrees of respiratory distress. All dogs had radiographic findings of soft tissue opacity in the area of the pharynx, larynx, or trachea, and several had narrowing of the tracheal lumen. Coagulation abnormalities (prolonged prothrombin time, activated partial thromboplastin time) were present in the four dogs that underwent testing. Four of five dogs were treated for the coagulopathy, presumably due to anticoagulant rodenticide toxicosis, and survived to discharge.Upper airway obstruction is an unusual presentation for anticoagulant rodenticide toxicosis in dogs. Raising the index of suspicion for this treatable condition may help clinicians to identify this sooner.
[Mh] Termos MeSH primário: Obstrução das Vias Respiratórias/veterinária
Doenças do Cão/induzido quimicamente
Hemorragia/veterinária
Envenenamento/veterinária
Rodenticidas/toxicidade
[Mh] Termos MeSH secundário: Obstrução das Vias Respiratórias/induzido quimicamente
Animais
Antídotos/administração & dosagem
Antídotos/uso terapêutico
Cães
Evolução Fatal
Feminino
Hemorragia/induzido quimicamente
Hemorragia/complicações
Hemorragia/tratamento farmacológico
Masculino
Envenenamento/patologia
Vitamina K 1/administração & dosagem
Vitamina K 1/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidotes); 0 (Rodenticides); 84-80-0 (Vitamin K 1)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE
[do] DOI:10.5326/JAAHA-MS-6658


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[PMID]:28264080
[Au] Autor:Matsui EC; Perzanowski M; Peng RD; Wise RA; Balcer-Whaley S; Newman M; Cunningham A; Divjan A; Bollinger ME; Zhai S; Chew G; Miller RL; Phipatanakul W
[Ad] Endereço:Division of Pediatric Allergy/Immunology, School of Medicine, Johns Hopkins University, Baltimore, Maryland.
[Ti] Título:Effect of an Integrated Pest Management Intervention on Asthma Symptoms Among Mouse-Sensitized Children and Adolescents With Asthma: A Randomized Clinical Trial.
[So] Source:JAMA;317(10):1027-1036, 2017 03 14.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: Professionally delivered integrated pest management (IPM) interventions can reduce home mouse allergen concentrations, but whether they reduce asthma morbidity among mouse-sensitized and exposed children and adolescents is unknown. Objective: To determine the effect of an IPM intervention on asthma morbidity among mouse-sensitized and exposed children and adolescents with asthma. Design, Setting, and Participants: Randomized clinical trial conducted in Baltimore, Maryland, and Boston, Massachusetts. Participants were mouse-sensitized and exposed children and adolescents (aged 5-17 years) with asthma randomized to receive professionally delivered IPM plus pest management education or pest management education alone. Enrollment occurred between May 2010 and August 2014; the final follow-up visit occurred on September 25, 2015. Interventions: Integrated pest management consisted of application of rodenticide, sealing of holes that could serve as entry points for mice, trap placement, targeted cleaning, allergen-proof mattress and pillow encasements, and portable air purifiers. Infestation was assessed every 3 months, and if infestation persisted or recurred, additional treatments were delivered. All participants received pest management education, which consisted of written material and demonstration of the materials needed to set traps and seal holes. Main Outcomes and Measures: The primary outcome was maximal symptom days defined as the highest number of days of symptoms in the previous 2 weeks among 3 types of symptoms (days of slowed activity due to asthma; number of nights of waking with asthma symptoms; and days of coughing, wheezing, or chest tightness) across 6, 9, and 12 months. Results: Of 361 children and adolescents who were randomized (mean [SD] age, 9.8 [3.2] years; 38% female; 181 in IPM plus pest management education group and 180 in pest management education alone group), 334 were included in the primary analysis. For the primary outcome, there was no statistically significant between-group difference for maximal symptom days across 6, 9, and 12 months with a median of 2.0 (interquartile range, 0.7-4.7) maximal symptom days in the IPM plus pest management education group and 2.7 (interquartile range, 1.3-5.0) maximal symptom days in the pest management education alone group (P = .16) and a ratio of symptom frequencies of 0.86 (95% CI, 0.69-1.06). Conclusions and Relevance: Among mouse-sensitized and exposed children and adolescents with asthma, an intensive year-long integrated pest management intervention plus pest management education vs pest management education alone resulted in no significant difference in maximal symptom days from 6 to 12 months. Trial Registration: clinicaltrials.gov Identifier: NCT01251224.
[Mh] Termos MeSH primário: Alérgenos/efeitos adversos
Asma/diagnóstico
Asma/prevenção & controle
Camundongos
Educação de Pacientes como Assunto/métodos
Controle de Pragas/métodos
Rodenticidas
[Mh] Termos MeSH secundário: Adolescente
Animais
Baltimore
Roupas de Cama, Mesa e Banho
Boston
Criança
Pré-Escolar
Poeira/prevenção & controle
Exposição Ambiental/efeitos adversos
Exposição Ambiental/análise
Exposição Ambiental/prevenção & controle
Feminino
Seres Humanos
Masculino
Avaliação de Sintomas/métodos
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Allergens); 0 (Dust); 0 (Rodenticides)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170307
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2016.21048


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[PMID]:28160742
[Au] Autor:López-García M; Romero-González R; Frenich AG
[Ad] Endereço:Research Group "Analytical Chemistry of Contaminants", Department of Chemistry and Physics, Research Centre for Agricultural and Food Biotechnology (BITAL), University of Almeria, Agrifood Campus of International Excellence, ceiA3, E-04120 Almeria, Spain.
[Ti] Título:Determination of rodenticides and related metabolites in rabbit liver and biological matrices by liquid chromatography coupled to Orbitrap high resolution mass spectrometry.
[So] Source:J Pharm Biomed Anal;137:235-242, 2017 Apr 15.
[Is] ISSN:1873-264X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:An analytical method based on ultra-high performance liquid chromatography (UHPLC) coupled to Orbitrap high resolution mass spectrometry was developed for the determination of rodenticides (bromadiolone, brodifacoum, difenacoum, chlorophacinone, diphacinone, coumachlor and warfarin) in liver matrix. Different extraction conditions were tested, obtaining the best results when the "dilute and shoot" method (acidified acetonitrile as extraction solvent) and a clean-up step with primary secondary amine (PSA) were used. The optimized method was validated, obtaining recoveries ranging from 60 to 120%. Repeatability and reproducibility were evaluated obtaining values lower than 20%, except for brodifacoum at 10µg/kg. Limits of quantification (LOQs) ranged from 0.1 to 0.5µg/kg, except for brodifacoum, which was 100µg/kg. Six liver samples were analyzed and diphacinone and chlorophacinone were detected in three samples at concentrations ranging from 4µg/kg to 13µg/kg. Moreover a retrospective screening of rodenticide metabolites in those samples and in animal forensic samples was developed based on Orbitrap capabilities. Brodifacoum was detected in three samples, and warfarin alcohol, which is a metabolite of warfarin, was also detected in one sample.
[Mh] Termos MeSH primário: Fígado/química
Fígado/metabolismo
Rodenticidas/química
Rodenticidas/metabolismo
[Mh] Termos MeSH secundário: 4-Hidroxicumarinas/química
Acetonitrilos/química
Animais
Cromatografia Líquida/métodos
Cumarínicos/química
Indanos/química
Espectrometria de Massas/métodos
Fenindiona/análogos & derivados
Fenindiona/química
Coelhos
Reprodutibilidade dos Testes
Estudos Retrospectivos
Varfarina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (4-Hydroxycoumarins); 0 (Acetonitriles); 0 (Coumarins); 0 (Indans); 0 (Rodenticides); 34Y6E0063Y (chlorophacinone); 54CA01C6JX (diphenadione); 5M7Y6274ZE (Phenindione); 5Q7ZVV76EI (Warfarin); A25P3CP5S7 (bromfenacoum); J2FR050NM5 (bromadiolone); SBA3K9U26B (difenacoum); UCD8XZW42P (coumachlor); Z072SB282N (acetonitrile)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170205
[St] Status:MEDLINE


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[PMID]:28131188
[Au] Autor:Jin JH; Lee ES; Choi JY; Kim JS
[Ad] Endereço:Department of Neurology, Konkuk University School of Medicine, Seoul, Republic of Korea.
[Ti] Título:Isolated cerebellar atrophy due to rodenticide (ß-fluoroethyl acetate) intoxication.
[So] Source:J Neurol Sci;373:208-209, 2017 Feb 15.
[Is] ISSN:1878-5883
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Mh] Termos MeSH primário: Acetatos/toxicidade
Ataxia Cerebelar/induzido quimicamente
Doenças Neurodegenerativas/induzido quimicamente
Rodenticidas/toxicidade
[Mh] Termos MeSH secundário: Atrofia/induzido quimicamente
Atrofia/diagnóstico por imagem
Ataxia Cerebelar/diagnóstico por imagem
Cerebelo/diagnóstico por imagem
Feminino
Seres Humanos
Meia-Idade
Doenças Neurodegenerativas/diagnóstico por imagem
Tentativa de Suicídio
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
0 (Acetates); 0 (Rodenticides); 462-26-0 (beta-fluoroethylacetate)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170130
[St] Status:MEDLINE


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[PMID]:28088390
[Au] Autor:Feinstein DL; Brodsky S; Weinberg G; van Breeman R; Rubinstein I
[Ad] Endereço:Jesse Brown VA Medical Center, Chicago, IL, 60612, USA; Department of Anesthesiology, University of Illinois, Chicago, IL 60612, USA; Department of Pathology, The Ohio State University, Columbus, OH, USA; Jesse Brown VA Medical Center, Chicago, IL, 60612, USA; Department of Anesthesiology, Universit
[Ti] Título:Brodifacoum poisoning: A clear and present danger to public health in the USA.
[So] Source:Toxicol Lett;268:71-72, 2017 Feb 15.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Mh] Termos MeSH primário: 4-Hidroxicumarinas/envenenamento
Anticoagulantes/envenenamento
Envenenamento/etiologia
Saúde Pública
Rodenticidas/envenenamento
[Mh] Termos MeSH secundário: Acidentes
Animais
Antídotos
Contaminação de Medicamentos
Seres Humanos
Incidentes com Feridos em Massa
Envenenamento/tratamento farmacológico
Medição de Risco
Fatores de Risco
Tentativa de Suicídio
Estados Unidos
[Pt] Tipo de publicação:LETTER
[Nm] Nome de substância:
0 (4-Hydroxycoumarins); 0 (Anticoagulants); 0 (Antidotes); 0 (Rodenticides); A25P3CP5S7 (bromfenacoum)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170213
[Lr] Data última revisão:
170213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170116
[St] Status:MEDLINE


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[PMID]:28033586
[Au] Autor:Fourel I; Damin-Pernik M; Benoit E; Lattard V
[Ad] Endereço:USC 1233 RS2GP, VetAgro Sup, INRA, Univ Lyon, F-69280, MARCY L'ETOILE, France. Electronic address: isabelle.fourel@vetagro-sup.fr.
[Ti] Título:Core-shell LC-MS/MS method for quantification of second generation anticoagulant rodenticides diastereoisomers in rat liver in relationship with exposure of wild rats.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1041-1042:120-132, 2017 Jan 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Second generation anticoagulant rodenticides (SGARs), pesticides used worldwide to control rodent populations, exist in two diastereoisomer chemical species because they own two stereogenic centers. A core-shell LC-MS/MS multi-residue method for comprehensive quantitative analysis of the diastereoisomers of five SGARs as well as three first generation anticoagulant rodenticide molecules has been fully validated in liver of rats according to a bioanalytical guideline. A core-shell column (superficially porous particles) has been chosen for its ability to separate the diastereomers of bromadiolone, difenacoum, brodifacoum, flocoumafen and difethialone and for its robustness to rat liver extracts. The highly selective chromatographic separation of the diastereoisomers contributes to good signal to noise ratios and then enhances the sensitivity of the method compared to the ones of fully porous columns. An elution gradient has been optimized with 10mM ammonium acetate and acetonitrile as aqueous/organic mobile phase respectively. Triple quadrupole mass detector has been used to achieve specifity and LLOQ from 0.92 to 2.2ng/g for each diastereoisomer, or first generation anticoagulant rodenticides. Then we evidenced diastereoisomeric ratios in liver of rats issued from not controlled exposure of wild rats (Rattus norvegicus) trapped in a French Parisian park through a campaign of rodent eradication. We compared them to diastereoisomeric ratios in SGARs commercial baits that contain both isomers, and showed that one of the two diastereoiomers had nearly disappeared in liver of rats. The proportions of cis-bromadiolone and trans-difenacoum were really lowered compared to the baits: 5/7 and 9/12 rats had only trans-bromadiolone and cis-difenacoum hepatic residues respectively. Liver persistence of the two diastereoisomers of bromadiolone and difenacoum was different due to differences in their pharmacokinetics in wild rats. The new core-shell LC-MS/MS method is particularly well adapted for further exploration of diastereoisomers ratios in rodent and predatory wildlife biological samples in order to evaluate ecological consequences of actual baits, to explore new formulated baits with a good balance between efficacity (ability to kill rodents) and diastereoisomers persistence, and hopefully to mitigate exposure of non-target species.
[Mh] Termos MeSH primário: Anticoagulantes/análise
Cromatografia Líquida/métodos
Fígado/química
Rodenticidas/análise
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Animais
Anticoagulantes/química
Anticoagulantes/farmacocinética
Modelos Lineares
Fígado/metabolismo
Ratos
Ratos Sprague-Dawley
Reprodutibilidade dos Testes
Rodenticidas/química
Rodenticidas/farmacocinética
Sensibilidade e Especificidade
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticoagulants); 0 (Rodenticides)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161230
[St] Status:MEDLINE



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