[PMID]: | 21861076 |
[Au] Autor: | Sun J; Wang Y; Qian Z; Hu C |
[Ad] Endereço: | Key Lab of Biorheological Science and Technology, College of Bioengineering, Ministry of Education, Research Center of Bioinspired Material Science and Engineering, Chongqing University, Chongqing 400030, China. |
[Ti] Título: | An approach to architecture 3D scaffold with interconnective microchannel networks inducing angiogenesis for tissue engineering. |
[So] Source: | J Mater Sci Mater Med;22(11):2565-71, 2011 Nov. |
[Is] ISSN: | 1573-4838 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | The angiogenesis of 3D scaffold is one of the major current limitations in clinical practice tissue engineering. The new strategy of construction 3D scaffold with microchannel circulation network may improve angiogenesis. In this study, 3D poly(D: ,L: -lactic acid) scaffolds with controllable microchannel structures were fabricated using sacrificial sugar structures. Melt drawing sugar-fiber network produced by a modified filament spiral winding method was used to form the microchannel with adjustable diameters and porosity. This fabrication process was rapid, inexpensive, and highly scalable. The porosity, microchannel diameter, interconnectivity and surface topographies of the scaffold were characterized by scanning electron microscopy. Mechanical properties were evaluated by compression tests. The mean porosity values of the scaffolds were in the 65-78% and the scaffold exhibited microchannel structure with diameter in the 100-200 µm range. The results showed that the scaffolds exhibited an adequate porosity, interconnective microchannel network, and mechanical properties. The cell culture studies with endothelial cells (ECs) demonstrated that the scaffold allowed cells to proliferate and penetrate into the volume of the entire scaffold. Overall, these findings suggest that the fabrication process offers significant advantages and flexibility in generating a variety of non-cytotoxic tissue engineering scaffolds with controllable distributions of porosity and physical properties that could provide the necessary physical cues for ECs and further improve angiogenesis for tissue engineering. |
[Mh] Termos MeSH primário: |
Neovascularização Fisiológica/fisiologia Engenharia Tecidual/métodos Tecidos Suporte
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[Mh] Termos MeSH secundário: |
Substâncias Antieletricidade Estática Materiais Biocompatíveis Células Cultivadas Células Endoteliais Seres Humanos Microscopia Eletrônica de Varredura Propriedades de Superfície
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[Pt] Tipo de publicação: | JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T |
[Nm] Nome de substância:
| 0 (Antistatic Agents); 0 (Biocompatible Materials) |
[Em] Mês de entrada: | 1203 |
[Cu] Atualização por classe: | 171021 |
[Lr] Data última revisão:
| 171021 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 110824 |
[St] Status: | MEDLINE |
[do] DOI: | 10.1007/s10856-011-4426-0 |
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