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[PMID]:29224759
[Au] Autor:Follent AM; Rumbach AF; Ward EC; Marshall J; Dodrill P; Lewindon P
[Ad] Endereço:School of Health and Rehabilitation Sciences, The University of Queensland, St Lucia, QLD 4072 Australia. Electronic address: anna.follent@uqconnect.edu.au.
[Ti] Título:Dysphagia and feeding difficulties post-pediatric ingestion injury: Perspectives of the primary caregiver.
[So] Source:Int J Pediatr Otorhinolaryngol;103:20-28, 2017 Dec.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To explore the experiences of children with dysphagia and/or feeding difficulties post-chemical or button battery ingestion injury from the perspective of the primary caregiver. METHOD: Five primary caregivers of children with a history of dysphagia and/or feeding difficulties post-ingestion injury (4 chemical, 1 button battery) completed the Children's Picky Eating Questionnaire (CPEQ), and participated in a semi-structured interview. Interviews explored experiences of caring for a child with dysphagia and/or feeding difficulties, impressions of services and supports, and additional impacts to the child and family. Content analysis was used to identify key themes. RESULT: Primary caregiver report and CPEQ results confirmed all children had some degree of persisting dysphagia and/or feeding difficulties at time of interview (mean 4.13 years' post-injury). Interviews identified five key themes: 1) The initial trauma of the injury, 2) The experience of associated and ongoing medical issues, 3) Managing altered oral intake, 4) Experiences of services and support, and 5) Impacts on the child, primary caregiver, and wider family unit. All caregivers reported significant challenges and concerns, and potential areas of service improvement were highlighted. CONCLUSION: The current data highlights specific issues experienced by primary caregivers, and poses areas for improving primary caregiver and family supports. Family-centered models of care are needed to support the whole family unit in caring for a child with dysphagia and/or feeding difficulties post-ingestion injury.
[Mh] Termos MeSH primário: Queimaduras Químicas/complicações
Cáusticos/toxicidade
Transtornos de Deglutição/etiologia
Transtornos da Alimentação e da Ingestão de Alimentos/etiologia
Corpos Estranhos/complicações
[Mh] Termos MeSH secundário: Adolescente
Cuidadores
Criança
Pré-Escolar
Ingestão de Alimentos
Seres Humanos
Lactente
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Caustics)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE


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[PMID]:28732800
[Au] Autor:Gonser P; Kaestner S; Jaminet P; Kaye K
[Ad] Endereço:Center for Plastic and Aesthetic Surgery, Ocean Clinic Marbella, Spain; Department for Plastic, Reconstructive, Hand and Burns Surgery, BG-Trauma Center, Eberhard Karls University Tuebingen, Germany. Electronic address: gophi@web.de.
[Ti] Título:Histological case-control study of peeling-induced skin changes by different peeling agents in surgically subcutaneous undermined skin flaps in facelift patients.
[So] Source:J Plast Reconstr Aesthet Surg;70(11):1660-1665, 2017 Nov.
[Is] ISSN:1878-0539
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A histological evaluation of peeling-induced skin changes in subcutaneous undermined preauricular facial skin flaps of nine patients was performed. There were three treatment groups: Trichloroacetic acid (TCA) 25%, TCA 40% and phenol/croton oil; one group served as control. Two independent evaluators determined the epidermal and dermal thickness and the depth of necrosis (micrometre). The percentual tissue damage due to the peeling was calculated, and a one-sample t-test for statistical significance was performed. On the basis of the histomorphological changes, peeling depth was classified as superficial, superficial-partial, deep-partial and full thickness chemical burn. The histological results revealed a progression of wound depth for different peeling agents without full thickness necrosis. TCA peels of up to 40% can be safely applied on subcutaneous undermined facial skin flaps without impairing the vascular patency, producing a predictable chemical burn, whereas deep peels such as phenol/croton oil peels should not be applied on subcutaneous undermined skin so as to not produce skin slough or necrosis by impairing vascular patency.
[Mh] Termos MeSH primário: Óleo de Cróton/efeitos adversos
Ritidoplastia/métodos
Dermatopatias/induzido quimicamente
Transplante de Pele/métodos
Pele/patologia
Retalhos Cirúrgicos
Ácido Tricloroacético/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Cáusticos/efeitos adversos
Fármacos Dermatológicos/efeitos adversos
Feminino
Seres Humanos
Meia-Idade
Pele/efeitos dos fármacos
Envelhecimento da Pele
Dermatopatias/patologia
Dermatopatias/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Caustics); 0 (Dermatologic Agents); 5V2JDO056X (Trichloroacetic Acid); 8001-28-3 (Croton Oil)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170723
[St] Status:MEDLINE


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[PMID]:28502435
[Au] Autor:Kurowski JA; Kay M
[Ad] Endereço:Department of Pediatric Gastroenterology, Hepatology and Nutrition, Cleveland Clinic Foundation, 9500 Euclid Avenue, Dept A111, Cleveland, OH 44195-0001, USA. Electronic address: kurowsj@ccf.org.
[Ti] Título:Caustic Ingestions and Foreign Bodies Ingestions in Pediatric Patients.
[So] Source:Pediatr Clin North Am;64(3):507-524, 2017 Jun.
[Is] ISSN:1557-8240
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Children inevitably swallow foreign material accidentally or intentionally. Each type of ingestion carries their own set of risks and complications, short and long term, some requiring immediate attention while others close monitoring. Alkalotic household cleaning products and lithium button batteries are increasingly common and damage the esophagus quickly. While many toys with rare-earth metals are banned, they are already present in many households and can cause necrosis of bowel that is between the magnets. This article reviews the incidence and assessment along with current literature to provide guidelines for management of pediatric patients with suspected caustic or foreign body ingestion.
[Mh] Termos MeSH primário: Queimaduras Químicas/diagnóstico
Cáusticos/toxicidade
Doenças do Esôfago/etiologia
Esôfago/lesões
Corpos Estranhos/diagnóstico
[Mh] Termos MeSH secundário: Queimaduras Químicas/terapia
Criança
Pré-Escolar
Endoscopia
Doenças do Esôfago/diagnóstico
Doenças do Esôfago/terapia
Corpos Estranhos/terapia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Caustics)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170516
[St] Status:MEDLINE


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[PMID]:28492712
[Au] Autor:Pennachi CMPS; Moura DTH; Amorim RBP; Guedes HG; Kumbhari V; Moura EGH
[Ad] Endereço:Serviço de Endoscopia Gastrointestinal do Departamento de Gastroenterologia da Faculdade de Medicina da Universidade de São Paulo (FM-USP), SP, Brasil.
[Ti] Título:LUGOL'S IODINE CHROMOENDOSCOPY VERSUS NARROW BAND IMAGE ENHANCED ENDOSCOPY FOR THE DETECTION OF ESOPHAGEAL CANCER IN PATIENTS WITH STENOSIS SECONDARY TO CAUSTIC/CORROSIVE AGENT INGESTION.
[So] Source:Arq Gastroenterol;54(3):250-254, 2017 Jul-Sept.
[Is] ISSN:1678-4219
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The diagnosis of corrosion cancer should be suspected in patients with corrosive ingestion if after a latent period of negligible symptoms there is development of dysphagia, or poor response to dilatation, or if respiratory symptoms develop in an otherwise stable patient of esophageal stenosis. Narrow Band Imaging detects superficial squamous cell carcinoma more frequently than white-light imaging, and has significantly higher sensitivity and accuracy compared with white-light. OBJECTIVE: To determinate the clinical applicability of Narrow Band Imaging versus Lugol´s solution chromendoscopy for detection of early esophageal cancer in patients with caustic/corrosive agent stenosis. METHODS: Thirty-eight patients, aged between 28-84 were enrolled and examined by both Narrow Band Imaging and Lugol´s solution chromendoscopy. A 4.9mm diameter endoscope was used facilitating examination of a stenotic area without dilation. Narrow Band Imaging was performed and any lesion detected was marked for later biopsy. Then, Lugol´s solution chromoendoscopy was performed and biopsies were taken at suspicious areas. Patients who had abnormal findings at the routine, Narrow Band Imaging or Lugol´s solution chromoscopy exam had their stenotic ring biopsied. RESULTS: We detected nine suspicious lesions with Narrow Band Imaging and 14 with Lugol´s solution chromendoscopy. The sensitivity and specificity of the Narrow Band Imaging was 100% and 80.6%, and with Lugol´s chromoscopy 100% and 66.67%, respectively. Five (13%) suspicious lesions were detected both with Narrow Band Imaging and Lugol's chromoscopy, two (40%) of these lesions were confirmed carcinoma on histopathological examination. CONCLUSION: Narrow Band Imaging is an applicable option to detect and evaluate cancer in patients with caustic /corrosive stenosis compared to the Lugol´s solution chromoscopy.
[Mh] Termos MeSH primário: Cáusticos/efeitos adversos
Corantes
Neoplasias Esofágicas/induzido quimicamente
Neoplasias Esofágicas/diagnóstico
Esofagoscopia/métodos
Iodetos
Imagem de Banda Estreita/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Constrição Patológica
Estudos Cross-Over
Estudos Transversais
Feminino
Seres Humanos
Masculino
Meia-Idade
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Caustics); 0 (Coloring Agents); 0 (Iodides); T66M6Y3KSA (Lugol's solution)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE


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[PMID]:28443378
[Au] Autor:Day RC; Bradberry SM; Sandilands EA; Thomas SHL; Thompson JP; Vale JA
[Ad] Endereço:a NPIS (Birmingham Unit) , City Hospital , Birmingham , UK.
[Ti] Título:Toxicity resulting from exposure to oven cleaners as reported to the UK National Poisons Information Service (NPIS) from 2009 to 2015.
[So] Source:Clin Toxicol (Phila);55(7):645-651, 2017 Aug.
[Is] ISSN:1556-9519
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Oven cleaning products contain corrosive substances, typically sodium or potassium hydroxide. OBJECTIVE: To determine the reported toxicity from exposure to oven cleaning products. METHODS: Telephone enquiries to the UK National Poisons Information Service regarding oven cleaning products were analysed retrospectively for the period January 2009 to December 2015. RESULTS: There were 796 enquiries relating to 780 patients. Ninety-six percent of the products involved in the reported exposures contained sodium hydroxide and/or potassium hydroxide. Ingestion alone (n = 285) or skin contact alone (n = 208) accounted for the majority of cases; inhalation alone (n = 101), eye contact alone (n = 97), and multiple routes of exposure (n = 89) accounted for the remainder. Ninety-five percent of patients exposed by inhalation, 94% exposed dermally and 85% reporting eye exposure, developed features of toxicity. Patients exposed by multiple routes developed symptoms in 70% of cases. Only 103 of the 285 patients ingested oven cleaner directly, whereas 182 patients ingested food they considered to have been contaminated with oven cleaner. In 100 of the 103 direct ingestions where the features and World Health Organisation/International Programme on Chemical Safety/European Commission/European Association of Poison Centres and Clinical Toxicologists Poisoning Severity Score were known, 56 reported symptoms which were minor in 51 cases. The most common features following ingestion were vomiting (n = 26), abdominal pain (n = 22) or pharyngitis (n = 15). Skin burns (n = 91) predominantly involving the hands or arms, occurred in 44% of dermal exposures. Following inhalation, patients frequently developed respiratory features (n = 52) including coughing and chest pain/tightness. Eye pain (n = 43) and conjunctivitis (n = 33) commonly occurred following ocular exposure. CONCLUSIONS: Most (71%) patients exposed to an oven cleaner irrespective of the route of exposure developed features of toxicity, though in most cases only minor features developed; moderate or severe features ensued in ∼4%. Those patients exposed dermally, ophthalmically or by inhalation developed features more frequently (≥85%) than those who ingested a product directly (56%).
[Mh] Termos MeSH primário: Acidentes Domésticos/estatística & dados numéricos
Cáusticos/envenenamento
Culinária/instrumentação
Exposição Ambiental/efeitos adversos
Utensílios Domésticos
Produtos Domésticos/envenenamento
Centros de Controle de Intoxicações/estatística & dados numéricos
Envenenamento/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Pré-Escolar
Desenho de Equipamento
Feminino
Seres Humanos
Lactente
Exposição por Inalação/efeitos adversos
Masculino
Meia-Idade
Envenenamento/diagnóstico
Estudos Retrospectivos
Índice de Gravidade de Doença
Fatores de Tempo
Reino Unido/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Caustics)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE
[do] DOI:10.1080/15563650.2017.1306070


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[PMID]:28375474
[Au] Autor:Banerjee JK; Saranga Bharathi R
[Ti] Título:Minimally invasive substernal colonic transposition for corrosive strictures of the upper aerodigestive tract.
[So] Source:Dis Esophagus;30(4):1-11, 2017 Apr 01.
[Is] ISSN:1442-2050
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Corrosive upper aerodigestive tract strictures are conventionally treated by open surgery. Surgical advancements permit these strictures to be addressed with minimal invasion. Corrosive strictures treated minimally invasively over a 2-year period (2014-2015) were audited. Colonic mobilization and retrosternal tunneling were performed laparoscopically. The left colic vessel-based isoperistaltic colonic/ileocolonic segment was transposed substernally into the neck, aided by miniceliotomy. Proximal anastomosis was side-to-side esophagocolic in all patients except those who underwent pharyngolaryngectomy or partial laryngectomy, where pharyngocolic/pyriform fossa-ileal anastomosis was employed. Distal anastomoses were colo-jejunal and colocolic/ileocolic in all the patients. Enteral nutrition and ambulation were commenced on the first postoperative day. Oral nutrition was commenced following a normal contrast swallow on the seventh postoperative day. Patients were followed up on an outpatient basis. Ten adults, aged between 19 and 40 years, were treated for acid-induced strictures. Esophagus and stomach were multiply strictured in all patients. Additionally, duodenum was involved in two patients while pharynx and larynx were strictured in three patients. Two patients underwent pharyngolaryngectomy. One patient underwent partial laryngectomy. The average operative time was 240 minutes (range: 210-300 minutes). The mean blood loss was 150 mL (range: 100-200 mL). One patient (10%) had cervical anastomotic leak on the ninth postoperative day, which was resolved spontaneously. One patient (10%) had proximal anastomotic stricture, requiring dilatation thrice. One patient (10%) had the transient left recurrent laryngeal nerve paresis, which was resolved spontaneously. All the patients are on oral solid diet. The followup ranged from 5 months to 2 years. Minimal access substernal colonic transposition is feasible and efficacious in restoring alimentary continuity in corrosive strictures.
[Mh] Termos MeSH primário: Queimaduras Químicas/cirurgia
Colo/cirurgia
Estenose Esofágica/cirurgia
Faringe/cirurgia
Trato Gastrointestinal Superior/cirurgia
[Mh] Termos MeSH secundário: Adulto
Anastomose Cirúrgica/métodos
Queimaduras Químicas/complicações
Cáusticos/toxicidade
Colo/lesões
Colo/patologia
Constrição Patológica
Estenose Esofágica/induzido quimicamente
Feminino
Seres Humanos
Laparoscopia/métodos
Laringectomia
Laringe/lesões
Laringe/patologia
Laringe/cirurgia
Masculino
Auditoria Médica
Duração da Cirurgia
Faringectomia
Faringe/lesões
Faringe/patologia
Resultado do Tratamento
Trato Gastrointestinal Superior/lesões
Trato Gastrointestinal Superior/patologia
Adulto Jovem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Caustics)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE
[do] DOI:10.1093/dote/dow030


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[PMID]:28333543
[Au] Autor:Noh SY; Kim HJ; Lee HJ; Park SH; Lee JS; Kim AY; Ha HK
[Ad] Endereço:1 All authors: Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic Ro, 43-Gil, Songpa-gu, Seoul, 05505, Korea.
[Ti] Título:Corrosive-Induced Carcinoma of Esophagus: Esophagographic and CT Findings.
[So] Source:AJR Am J Roentgenol;208(6):1237-1243, 2017 Jun.
[Is] ISSN:1546-3141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The purpose of this study was to evaluate the esophagographic and CT findings of corrosive esophageal cancer. MATERIALS AND METHODS: The records of all patients who presented with corrosive esophageal strictures at one institution between June 1989 and April 2015 were retrospectively identified. The search yielded the records of 15 patients with histopathologically proven esophageal cancer. Esophagograms (13 patients) and chest CT images (14 patients) were interpreted independently by two reviewers. Esophagographic findings included the location of tumor, morphologic type, presence and length of mucosal irregularity, presence of asymmetric involvement, and presence of rigidity. CT findings included presence and type of esophageal wall thickening, pattern of enhancement, presence of periesophageal infiltration, and presence of hilar or mediastinal lymphadenopathy. RESULTS: Esophagography showed that the tumor was involved with the stenotic portion in 10 of the 13 patients (76.9%). The most common morphologic feature was a polypoid mass, in 10 patients. In 12 patients (92.3%), mucosal irregularities were observed; the mean affected length was 4.92 cm. Asymmetric involvement and rigidity were observed in nine patients (69.2%). On CT scans, eccentric wall thickening was observed in 10 of the 14 patients (71.4%), homogeneous enhancement in nine (64.2%), and periesophageal infiltration in 11 (78.5%). CONCLUSION: Esophagography commonly shows corrosive esophageal cancer as a polypoid mass with long-segment mucosal irregularities at the stenotic portion, asymmetric involvement, and rigidity. CT shows eccentric esophageal wall thickening with homogeneous enhancement and periesophageal infiltration, which are suggestive of the development of malignancy in patients with corrosive esophageal strictures.
[Mh] Termos MeSH primário: Queimaduras Químicas/diagnóstico por imagem
Cáusticos/envenenamento
Neoplasias Esofágicas/induzido quimicamente
Neoplasias Esofágicas/diagnóstico por imagem
Estenose Esofágica/induzido quimicamente
Estenose Esofágica/diagnóstico por imagem
Tomografia Computadorizada por Raios X
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Queimaduras Químicas/complicações
Esôfago/diagnóstico por imagem
Feminino
Seres Humanos
Masculino
Meia-Idade
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Caustics)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE
[do] DOI:10.2214/AJR.16.17138


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[PMID]:28319774
[Au] Autor:Li J; Hu H; Li H; Huang L; Chen L; Ni Y
[Ad] Endereço:College of Material Engineering, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Limerick Pulp and Paper Centre, Department of Chemical Engineering, University of New Brunswick, Fredericton, New Brunswick E3B 5A3, Canada; Key Laboratory of Pulp and Paper Science & Technology of
[Ti] Título:Kinetics and mechanism of hemicelluloses removal from cellulosic fibers during the cold caustic extraction process.
[So] Source:Bioresour Technol;234:61-66, 2017 Jun.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The effective separation of hemicelluloses and cellulose is desirable for the production of high-purity cellulose, which is a sustainable raw material for many value-added applications. For this purpose, the kinetics and mechanism of hemicelluloses removal from the cold caustic extraction (CCE) were investigated in the present study. The hemicelluloses removal process consists of: 1) the bulk phase, characteristic of significant hemicelluloses removal; 2) the transition phase, hemicelluloses transferring from the inner to the outer region of the fiber wall, with negligible overall hemicelluloses removal; 3) the residual phase, presenting a weak but continuing hemicelluloses removal. Furthermore, the enzymatic peeling method was adopted to study the fundamentals of hemicelluloses removal. The results showed that the molecular weight of hemicelluloses is the main parameter governing their diffusion/dissolution processes, and that the low molecular weight hemicelluloses are preferentially removed.
[Mh] Termos MeSH primário: Celulose/química
[Mh] Termos MeSH secundário: Cáusticos
Difusão
Cinética
Peso Molecular
Polissacarídeos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Caustics); 0 (Polysaccharides); 9004-34-6 (Cellulose)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170321
[St] Status:MEDLINE


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[PMID]:28148851
[Au] Autor:Grallert A; Hagan IM
[Ad] Endereço:CRUK Cell Division Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester M20 4BX, United Kingdom Agnes.Grallert@cruk.manchester.ac.uk Iain.Hagan@cruk.manchester.ac.uk.
[Ti] Título:Preparation of Protein Extracts from Schizosaccharomyces pombe Using Trichloroacetic Acid Precipitation.
[So] Source:Cold Spring Harb Protoc;2017(2):pdb.prot091579, 2017 Feb 01.
[Is] ISSN:1559-6095
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Schizosaccharomyces pombe is an attractive model organism with which to study core principles of conserved molecular cell biology processes. The ability to monitor protein behavior following separation by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) underpins much of this activity. Here we describe a robust protocol for the preparation of protein samples for analysis by SDS-PAGE.
[Mh] Termos MeSH primário: Precipitação Química
Proteínas Fúngicas/isolamento & purificação
Schizosaccharomyces/química
Ácido Tricloroacético/metabolismo
[Mh] Termos MeSH secundário: Cáusticos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Caustics); 0 (Fungal Proteins); 5V2JDO056X (Trichloroacetic Acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170203
[St] Status:MEDLINE
[do] DOI:10.1101/pdb.prot091579


  10 / 1595 MEDLINE  
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[PMID]:27998025
[Au] Autor:El Mofty M; Esmat S; Hunter N; Mashaly HM; Dorgham D; Shaker O; Ibrahim S
[Ad] Endereço:Dermatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
[Ti] Título:Effect of different types of therapeutic trauma on vitiligo lesions.
[So] Source:Dermatol Ther;30(2), 2017 Mar.
[Is] ISSN:1529-8019
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:New treatment modalities for vitiligo acting by changing certain cytokines and metalloproteinases are newly emerging. The aim of this work is to To assess the efficacy of trichloroacetic acid (TCA) chemical peel, dermapen, and fractional CO laser in treatment of stable non-segmental vitiligo and to detect their effects on IL-17 and MMP-9 levels. Thirty patients with stable vitiligo were recruited in a randomized controlled study. They were randomly categorized into three equal groups. Group 1: TCA peel, Group 2: dermapen machine, and Group 3: Fractional CO laser. Skin biopsies were taken from treated areas and from control areas for which MMP-9 and IL-17 tissue levels were measured using ELISA. The 30 vitiligo patients had low basal tissue MMP-9 levels and high baseline IL-17 tissue levels. As regards the three different used modalities, all of them caused rise in MMP-9 as well as IL-17 levels and almost their levels were much more elevated with repetition of the previously mentioned traumatic procedures. TCA 25% peel proved to be the most effective modality both clinically and laboratory and it can be used prior or with other conventional therapies in the treatment of vitiligo.
[Mh] Termos MeSH primário: Cáusticos/administração & dosagem
Abrasão Química
Técnicas Cosméticas
Lasers de Gás/uso terapêutico
Terapia com Luz de Baixa Intensidade/instrumentação
Pigmentação da Pele
Pele
Ácido Tricloroacético/administração & dosagem
Vitiligo/terapia
[Mh] Termos MeSH secundário: Administração Cutânea
Adolescente
Adulto
Biópsia
Cáusticos/efeitos adversos
Abrasão Química/efeitos adversos
Técnicas Cosméticas/efeitos adversos
Técnicas Cosméticas/instrumentação
Egito
Feminino
Seres Humanos
Interleucina-17/metabolismo
Lasers de Gás/efeitos adversos
Terapia com Luz de Baixa Intensidade/efeitos adversos
Masculino
Metaloproteinase 9 da Matriz/metabolismo
Meia-Idade
Miniaturização
Agulhas
Pele/efeitos dos fármacos
Pele/enzimologia
Pele/imunologia
Pele/efeitos da radiação
Pigmentação da Pele/efeitos dos fármacos
Pigmentação da Pele/efeitos da radiação
Fatores de Tempo
Resultado do Tratamento
Ácido Tricloroacético/efeitos adversos
Vitiligo/diagnóstico
Vitiligo/enzimologia
Vitiligo/imunologia
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Caustics); 0 (Interleukin-17); 5V2JDO056X (Trichloroacetic Acid); EC 3.4.24.35 (MMP9 protein, human); EC 3.4.24.35 (Matrix Metalloproteinase 9)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161221
[St] Status:MEDLINE
[do] DOI:10.1111/dth.12447



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