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[PMID]:28917452
[Au] Autor:Chaowattanapanit S; Silpa-Archa N; Kohli I; Lim HW; Hamzavi I
[Ad] Endereço:Department of Dermatology, Henry Ford Hospital, Detroit, Michigan; Department of Medicine, Faculty of Medicine, Srinagarind Hospital, Khon Kaen University, Khon Kaen, Thailand.
[Ti] Título:Postinflammatory hyperpigmentation: A comprehensive overview: Treatment options and prevention.
[So] Source:J Am Acad Dermatol;77(4):607-621, 2017 Oct.
[Is] ISSN:1097-6787
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Postinflammatory hyperpigmentation (PIH) occurs after various dermatoses, exogenous stimuli, and dermatologic procedures. The clinical course of PIH is chronic and unpredictable, although the probability of resolution of epidermal hyperpigmentation is better than those of dermal hyperpigmentation. PIH can be prevented or alleviated. When it does occur, the underlying inflammatory conditions should be sought and treated as the first step to reduce the progression of inflammation and PIH (which is an inflammatory consequence). If the inflammatory conditions subsides or there is no evidence of inflammation at the time of diagnosis, the treatments of PIH should be considered as the next step. Understanding the available treatment options helps the physician choose the appropriate treatment for each patient. Having a reproducible model for PIH is essential for the development of treatment modalities. The second article in this 2-part continuing medical education series on PIH specifically addresses the evidence that supports medical and procedural treatments of PIH and other forms of acquired hyperpigmentation. It also describes a PIH model and provides an algorithm for clinical practice along with discussion about the prevention of PIH.
[Mh] Termos MeSH primário: Dermatite/complicações
Fármacos Dermatológicos/uso terapêutico
Hiperpigmentação/terapia
Preparações Clareadoras de Pele/uso terapêutico
[Mh] Termos MeSH secundário: Antioxidantes/uso terapêutico
Abrasão Química
Combinação de Medicamentos
Seres Humanos
Hidroquinonas/uso terapêutico
Hiperpigmentação/prevenção & controle
Terapia a Laser
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antioxidants); 0 (Dermatologic Agents); 0 (Drug Combinations); 0 (Hydroquinones); 0 (Skin Lightening Preparations); XV74C1N1AE (hydroquinone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170918
[St] Status:MEDLINE


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[PMID]:28684314
[Au] Autor:Kim KI; Jeong HB; Ro H; Lee JH; Kim CD; Yoon TJ
[Ad] Endereço:Department of Dermatology and Institute of Health Sciences, School of Medicine, Gyeongsang National University & Hospital, Jinju, Republic of Korea.
[Ti] Título:Inhibitory effect of 5-iodotubercidin on pigmentation.
[So] Source:Biochem Biophys Res Commun;490(4):1282-1286, 2017 Sep 02.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Melanin pigments are the primary contributors for the skin color. They are produced in melanocytes and then transferred to keratinocytes, eventually giving various colors on skin surface. Although many depigmenting and/or skin-lightening agents have been developed, there is still a growing demand on materials for reducing pigmentation. We attempted to find materials for depigmentation and/or skin-lightening using the small molecule compounds commercially available, and found that 5-iodotubercidin had inhibitory potential on pigmentation. When HM3KO melanoma cells were treated with 5-iodotubercidin, pigmentation was dramatically reduced. The 5-iodotubercidin decreased the protein level for pigmentation-related molecules such as MITF, tyrosinase, and TRP1. In addition, 5-iodotubercidin decreased the phosphorylation of CREB, while increased the phosphorylation of AKT and ERK. These data suggest that 5-iodotubercidin inhibits melanogenesis via the regulation of intracellular signaling related with pigmentation. Finally, 5-iodotubercidin markedly inhibited the melanogenesis of zebrafish embryos, an in vivo evaluation model for pigmentation. Together, these data suggest that 5-iodotubercidin can be developed as a depigmenting and/or skin-lightening agent.
[Mh] Termos MeSH primário: Inibidores Enzimáticos/farmacologia
Melanócitos/efeitos dos fármacos
Pigmentação/efeitos dos fármacos
Preparações Clareadoras de Pele/farmacologia
Pele/efeitos dos fármacos
Tubercidina/análogos & derivados
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/antagonistas & inibidores
Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/genética
Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/metabolismo
Embrião não Mamífero/efeitos dos fármacos
Regulação da Expressão Gênica
Seres Humanos
Melanócitos/citologia
Melanócitos/metabolismo
Fator de Transcrição Associado à Microftalmia/antagonistas & inibidores
Fator de Transcrição Associado à Microftalmia/genética
Fator de Transcrição Associado à Microftalmia/metabolismo
Proteína Quinase 1 Ativada por Mitógeno/genética
Proteína Quinase 1 Ativada por Mitógeno/metabolismo
Proteína Quinase 3 Ativada por Mitógeno/genética
Proteína Quinase 3 Ativada por Mitógeno/metabolismo
Monofenol Mono-Oxigenase/antagonistas & inibidores
Monofenol Mono-Oxigenase/genética
Monofenol Mono-Oxigenase/metabolismo
Fosforilação/efeitos dos fármacos
Pigmentação/genética
Proteínas Proto-Oncogênicas c-akt/agonistas
Proteínas Proto-Oncogênicas c-akt/genética
Proteínas Proto-Oncogênicas c-akt/metabolismo
Transdução de Sinais
Pele/metabolismo
Tripsina/genética
Tripsina/metabolismo
Tubercidina/farmacologia
Peixe-Zebra
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CREB1 protein, human); 0 (Cyclic AMP Response Element-Binding Protein); 0 (Enzyme Inhibitors); 0 (MITF protein, human); 0 (Microphthalmia-Associated Transcription Factor); 0 (Skin Lightening Preparations); 24386-93-4 (5-iodotubercidin); EC 1.14.18.1 (Monophenol Monooxygenase); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 2.7.11.24 (MAPK1 protein, human); EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1); EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3); EC 3.4.21.4 (PRSS1 protein, human); EC 3.4.21.4 (Trypsin); M351LCX45Y (Tubercidin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE


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[PMID]:28619537
[Au] Autor:Jo H; Choi M; Sim J; Viji M; Li S; Lee YH; Kim Y; Seo SY; Zhou Y; Lee K; Kim WJ; Hong JT; Lee H; Jung JK
[Ad] Endereço:College of Pharmacy and Medicinal Research Center (MRC), Chungbuk National University, Cheongju 28160, Republic of Korea.
[Ti] Título:Synthesis and biological evaluation of caffeic acid derivatives as potent inhibitors of α-MSH-stimulated melanogenesis.
[So] Source:Bioorg Med Chem Lett;27(15):3374-3377, 2017 08 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We have disclosed our effort to develop caffeic acid derivatives as potent and non-toxic inhibitors of α-MSH-stimulated melanogenesis to treat pigmentation disorders and skin medication including a cosmetic skin-whitening agent. The SAR studies revealed that cyclohexyl ester and secondary amide derivatives of caffeic acid showed significant inhibitory activities.
[Mh] Termos MeSH primário: Ácidos Cafeicos/farmacologia
Preparações Clareadoras de Pele/farmacologia
Pigmentação da Pele/efeitos dos fármacos
alfa-MSH/antagonistas & inibidores
[Mh] Termos MeSH secundário: Animais
Ácidos Cafeicos/síntese química
Ácidos Cafeicos/química
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Camundongos
Estrutura Molecular
Preparações Clareadoras de Pele/síntese química
Preparações Clareadoras de Pele/química
Relação Estrutura-Atividade
alfa-MSH/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Caffeic Acids); 0 (Skin Lightening Preparations); 581-05-5 (alpha-MSH); U2S3A33KVM (caffeic acid)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170617
[St] Status:MEDLINE


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[PMID]:28403270
[Au] Autor:Quay ER; Chang YC; Graber E
[Ti] Título:Evidence for Anti-Aging South Korean Cosmeceuticals.
[So] Source:J Drugs Dermatol;16(4):358-363, 2017 Apr 01.
[Is] ISSN:1545-9616
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:

As the market for South Korean skin care products grows in the U.S. and worldwide, consumers will increasingly seek advice from dermatologists regarding their efficacy. In this paper, the evidence behind the anti-aging and skin whitening activity of ingredients in the most popular South Korean skin care products was reviewed and critically evaluated. Industry profit data from Euromonitor was obtained to identify the top cosmeceutical brands by retail value in South Korea. The top selling products and their ingredients were then identified from individual brand websites. A comprehensive literature search was conducted using Pubmed to identify and grade the anti-aging and whitening efficacy for nine popular ingredients: licorice, niacinamide, beta-glucan, snail mucus, ginkgo biloba, ginseng, green tea, pomegranate, and soy. Of the various ingredients reviewed, niacinamide, green tea, licorice, and soy have the most published data for anti-aging and whitening activity. Although the literature shows modest results, small sample sizes limit interpretation. High-level evidence to support the use of South Korean skin care products in anti-aging and skin whitening is lacking.

J Drugs Dermatol. 2017;16(4):358-364.

.
[Mh] Termos MeSH primário: Cosmecêuticos/uso terapêutico
Hiperpigmentação/tratamento farmacológico
Preparações de Plantas/uso terapêutico
Envelhecimento da Pele/efeitos dos fármacos
Preparações Clareadoras de Pele/uso terapêutico
[Mh] Termos MeSH secundário: Administração Tópica
Ensaios Clínicos como Assunto
Cosmecêuticos/administração & dosagem
Seres Humanos
Preparações de Plantas/administração & dosagem
República da Coreia
Preparações Clareadoras de Pele/administração & dosagem
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cosmeceuticals); 0 (Plant Preparations); 0 (Skin Lightening Preparations)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE


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[PMID]:28317530
[Au] Autor:Grimes PE; Nashawati R
[Ad] Endereço:Vitiligo & Pigmentation Institute of Southern California, 5670 Wilshire Boulevard #650, Los Angeles, CA 90036, USA; Division of Dermatology, David Geffen School of Medicine, University of California, Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA. Electronic address: pegrimesmd@aol.com.
[Ti] Título:Depigmentation Therapies for Vitiligo.
[So] Source:Dermatol Clin;35(2):219-227, 2017 Apr.
[Is] ISSN:1558-0520
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The general goals of medical management of vitiligo are to repigment vitiliginous areas of skin and to stabilize the progression of depigmentation. However, for some patients with vitiligo affecting extensive body surface areas who are unresponsive to repigmentation therapies, depigmentation of the remaining normal skin may be a better choice. Candidates for depigmentation therapy should be carefully screened and patient education is essential. Permanent topical therapies used for depigmentation include monobenzyl ether of hydroquinone, 4-methoxyphenol, and 88% phenol. Physical modalities, such as cryotherapy and lasers, are also being used successfully.
[Mh] Termos MeSH primário: Adjuvantes Imunológicos/uso terapêutico
Anisóis/uso terapêutico
Crioterapia
Hidroquinonas/uso terapêutico
Terapia com Luz de Baixa Intensidade
Fenol/uso terapêutico
Inibidores de Proteínas Quinases/uso terapêutico
Preparações Clareadoras de Pele/uso terapêutico
Vitiligo/terapia
[Mh] Termos MeSH secundário: Aminoquinolinas/uso terapêutico
Superfície Corporal
Ciclopropanos/uso terapêutico
Seres Humanos
Mesilato de Imatinib/uso terapêutico
Seleção de Pacientes
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Adjuvants, Immunologic); 0 (Aminoquinolines); 0 (Anisoles); 0 (Cyclopropanes); 0 (Hydroquinones); 0 (Protein Kinase Inhibitors); 0 (Skin Lightening Preparations); 339NCG44TV (Phenol); 6HT8U7K3AM (mequinol); 8A1O1M485B (Imatinib Mesylate); 9L2KA76MG5 (monobenzone); I7G14NW5EC (diphenylcyclopropenone); P1QW714R7M (imiquimod)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170321
[St] Status:MEDLINE


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[PMID]:28317525
[Au] Autor:Harris JE
[Ad] Endereço:Department of Dermatology, University of Massachusetts Medical School, 364 Plantation Street, LRB 225, Worcester, MA 01605, USA. Electronic address: John.Harris@umassmed.edu.
[Ti] Título:Chemical-Induced Vitiligo.
[So] Source:Dermatol Clin;35(2):151-161, 2017 Apr.
[Is] ISSN:1558-0520
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chemical-induced depigmentation of the skin has been recognized for more than 75 years, first as an occupational hazard but then extending to those using household commercial products as common as hair dyes. Since their discovery, these chemicals have been used therapeutically in patients with severe vitiligo to depigment their remaining skin and improve their appearance. Because chemical-induced depigmentation is clinically and histologically indistinguishable from nonchemically induced vitiligo, and because these chemicals appear to induce melanocyte autoimmunity, this phenomenon should be known as "chemical-induced vitiligo," rather than less accurate terms that have been previously used.
[Mh] Termos MeSH primário: Tinturas para Cabelo/efeitos adversos
Hipopigmentação/induzido quimicamente
Fenóis/efeitos adversos
Preparações Clareadoras de Pele/efeitos adversos
Vitiligo/induzido quimicamente
[Mh] Termos MeSH secundário: Autoimunidade
Catecóis/efeitos adversos
Seres Humanos
Hidroquinonas/efeitos adversos
Fenilenodiaminas/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Catechols); 0 (Hair Dyes); 0 (Hydroquinones); 0 (Phenols); 0 (Phenylenediamines); 0 (Skin Lightening Preparations); 9A069144KR (p-tert-butyl catechol); 9L2KA76MG5 (monobenzone); XV74C1N1AE (hydroquinone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170321
[St] Status:MEDLINE


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[PMID]:28190468
[Au] Autor:Srivilai J; Phimnuan P; Jaisabai J; Luangtoomma N; Waranuch N; Khorana N; Wisuitiprot W; Scholfield CN; Champachaisri K; Ingkaninan K
[Ad] Endereço:Bioscreening Unit, Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, Thailand.
[Ti] Título:Curcuma aeruginosa Roxb. essential oil slows hair-growth and lightens skin in axillae; a randomised, double blinded trial.
[So] Source:Phytomedicine;25:29-38, 2017 Feb 15.
[Is] ISSN:1618-095X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Androgenic hair-growth contributes to secondary gender characteristics but can be troublesome in women. Inhibiting axillary hair-growth via 5-α-reductases using the Thai medicinal plant, Curcuma aeruginosa Roxb. is an attractive treatment strategy. HYPOTHESIS/PURPOSE: C. aeruginosa essential oil (CA-oil) formulated as a lotion is an efficacious and safe inhibitor of axillary hair growth. STUDY DESIGN: This trial was a single center, randomized, double-blind, placebo controlled 10 weeks, intervention in 60 women (18-23 years) and 2 weeks washout with axillary hair length was the primary end-point. METHODS: Bioactive-enriched essential oil of C. aeruginosa was formulated with a base lotion. All participants were pre-challenged with lotions by 4-h patch irritation tests to exclude skin reactions. Participants were randomly allocated to use either 1 or 5%w/w CA-oil lotion on one axilla and base-lotion (placebo) to the other for 10 weeks followed by placebo in both axillae for 2 weeks. Every week, the axillae were photographed to measure hair lengths, shaved, and roll-on applicators containing appropriate lotion replaced. Also, skin melanin by spectrophotometry and hair density were measured. RESULTS: From weeks 5-11 of trial, 1 and 5%w/w CA-oil retarded growth by 13 ± 1.5% and 16 ± 0.9% respectively, while placebo was ineffective. CA-oil had no influence on hair density. Both concentrations of CA-oil rapidly and equally effectively brightened skin within 3 weeks which persisted 2 weeks after treatment ceased while placebo darkened the skin. Adherence appeared good as judged by consistency of lotion consumption and between axillae. Participants were satisfied with the treatment and reported reduced hairiness, freedom from any discomforts, but product odour attracted some negative comment. No adverse reactions ascribed to CA-oil were detected or reported. CONCLUSION: This study points to a safe and efficacious dual action on retarding hair-growth and skin lightening by CA-oil.
[Mh] Termos MeSH primário: Axila
Curcuma/química
Cabelo/efeitos dos fármacos
Óleos Voláteis/farmacologia
Extratos Vegetais/farmacologia
Pele/efeitos dos fármacos
[Mh] Termos MeSH secundário: Administração Tópica
Adolescente
Adulto
Método Duplo-Cego
Feminino
Cabelo/crescimento & desenvolvimento
Seres Humanos
Creme para a Pele
Preparações Clareadoras de Pele
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Oils, Volatile); 0 (Plant Extracts); 0 (Skin Lightening Preparations)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170517
[Lr] Data última revisão:
170517
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170214
[St] Status:MEDLINE


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[PMID]:28135782
[Au] Autor:de Los A Mesurado M; Arias Cassará ML; Misico R; Bardón A; Ybarra MI; Cartagena E
[Ad] Endereço:Instituto de Química Orgánica, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, Ayacucho, 471, 4000, Tucumán, Argentina.
[Ti] Título:A New Depigmenting-Antifungal Methylated Grindelane from Grindelia chiloensis.
[So] Source:Chem Biodivers;14(5), 2017 May.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The new methylated grindelane diterpenoid, 7ß-hydroxy-8(17)-dehydrogrindelic acid (1b), together with the known 7α-hydroxy-8(17)-dehydrogrindelic acid (2a), 6-oxogrindelic acid (3a), 4ß-hydroxy-6-oxo-19-norgrindelic (4a), 19-hydroxygrindelic acid (5a), 18-hydroxygrindelic acid (6a), 4α-carboxygrindelic acid (7a), 17-hydroxygrindelic acid (8a), 6α-hydroxygrindelic acid (9a), 8,17-bisnor-8-oxagrindelic acid (10a), 7α,8α-epoxygrindelic acid (11a), and strictanonic acid (12a) as methyl esters were obtained from an Argentine collection of Grindelia chiloensis (Cornel.) Cabrera. Their structures and relative configurations were established on the basis of spectroscopic analysis. CHCl extract from the aerial parts and their pure compounds were evaluated for their antifungal and depigmenting effects. Methyl ester derivative of 10a (10b) exhibited a remarkable mycelial growth inhibition against Botritis cinerea with an IC of 13.5 µg ml . While the new grindelane 1b exerted a clear color reduction of the yellow-orange pigment developed by Fusarium oxysporum against UV-induced damage.
[Mh] Termos MeSH primário: Antifúngicos/isolamento & purificação
Grindelia/química
Preparações Clareadoras de Pele/isolamento & purificação
[Mh] Termos MeSH secundário: Antifúngicos/farmacologia
Diterpenos
Fusarium/efeitos dos fármacos
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Extratos Vegetais/química
Preparações Clareadoras de Pele/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Diterpenes); 0 (Plant Extracts); 0 (Skin Lightening Preparations); 0 (ent-7beta,11alpha,14-trihydroxy-18-aldehyde-11beta-20-epoxy-kaur-16-en15-one)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170131
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201600426


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[PMID]:28114924
[Au] Autor:Kuo YH; Chen CC; Wu PY; Wu CS; Sung PJ; Lin CY; Chiang HM
[Ad] Endereço:Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, 404, Taiwan.
[Ti] Título:N-(4-methoxyphenyl) caffeamide-induced melanogenesis inhibition mechanisms.
[So] Source:BMC Complement Altern Med;17(1):71, 2017 Jan 23.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The derivative of caffeamide exhibits antioxidant and antityrosinase activity. The activity and mechanism of N-(4-methoxyphenyl) caffeamide (K36E) on melanogenesis was investigated. METHODS: B16F0 cells were treated with various concentrations of K36E; the melanin contents and related signal transduction were studied. Western blotting assay was applied to determine the protein expression, and spectrophotometry was performed to identify the tyrosinase activity and melanin content. RESULTS: Our results indicated that K36E reduced α-melanocyte-stimulating hormone (α-MSH)-induced melanin content and tyrosinase activity in B16F0 cells. In addition, K36E inhibited the expression of phospho-cyclic adenosine monophosphate (cAMP)-response element-binding protein, microphthalmia-associated transcription factor (MITF), tyrosinase, and tyrosinase-related protein-1 (TRP-1). K36E activated the phosphorylation of protein kinase B (AKT) and glycogen synthase kinase 3 beta (GSK3ß), leading to the inhibition of MITF transcription activity. K36E attenuated α-MSH induced cAMP pathways, contributing to hypopigmentation. CONCLUSIONS: K36E regulated melanin synthesis through reducing the expression of downstream proteins including p-CREB, p-AKT, p-GSK3ß, tyrosinase, and TRP-1, and activated the transcription factor, MITF. K36E may have the potential to be developed as a skin whitening agent.
[Mh] Termos MeSH primário: Anilidas/farmacologia
Ácidos Cafeicos/farmacologia
Melaninas/antagonistas & inibidores
[Mh] Termos MeSH secundário: Anilidas/síntese química
Animais
Ácidos Cafeicos/síntese química
Linhagem Celular Tumoral
Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/antagonistas & inibidores
Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/metabolismo
Glicogênio Sintase Quinase 3 beta/metabolismo
Interferon Tipo I/antagonistas & inibidores
Interferon Tipo I/metabolismo
Melaninas/biossíntese
Camundongos
Fator de Transcrição Associado à Microftalmia/antagonistas & inibidores
Fator de Transcrição Associado à Microftalmia/metabolismo
Monofenol Mono-Oxigenase/antagonistas & inibidores
Monofenol Mono-Oxigenase/metabolismo
Proteínas da Gravidez/antagonistas & inibidores
Proteínas da Gravidez/metabolismo
Proteínas Proto-Oncogênicas c-akt/metabolismo
Transdução de Sinais/efeitos dos fármacos
Preparações Clareadoras de Pele/síntese química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anilides); 0 (Caffeic Acids); 0 (Cyclic AMP Response Element-Binding Protein); 0 (Interferon Type I); 0 (Melanins); 0 (Microphthalmia-Associated Transcription Factor); 0 (Mitf protein, mouse); 0 (N-(4-methoxyphenyl)caffeamide); 0 (Pregnancy Proteins); 0 (Skin Lightening Preparations); 0 (trophoblastin); EC 1.14.18.1 (Monophenol Monooxygenase); EC 2.7.11.1 (Glycogen Synthase Kinase 3 beta); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-016-1554-6


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[PMID]:28102816
[Au] Autor:Niu HX; Li SH; Li HY; Chen YH; Liu WW; Li PL; Long HB
[Ti] Título:Clinicopathological features, diagnosis, and treatment of IgA nephropathy with minimal change disease related to exposure to mercury-containing cosmetics: a case report
.
[So] Source:Clin Nephrol;87 (2017)(4):196-201, 2017 Apr.
[Is] ISSN:0301-0430
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:AIM: Membranous nephropathy and minimal change disease (MCD) have been involved in mercury-induced nephrotic syndrome. IgA nephropathy is not known to be a common pathological type. In the present article, we report a case of IgA nephropathy with MCD following exposure to mercury-containing skin lightening cream. MATERIAL AND METHODS: The patient was a 39-year-old woman who presented with nephrotic syndrome. She had a 6-month history of using as many as 8 kinds of skin-lightening creams, and urinary mercury excretion was high. Renal biopsy revealed IgA nephropathy with MCD. The use of cosmetics was stopped and chelation therapy was given. After 4 courses (1 month) of chelation therapy, there was a complete remission of proteinuria and hematuria, and urine tests remained normal during the 5-year follow-up period. RESULTS AND CONCLUSIONS: The unique clinical and pathological features of IgA nephropathy with MCD had raised the controversial question of whether MCD and IgA deposition are separate entities or a common pathophysiology. Repeated renal biopsy and similar cases were helpful and should be carried out as far as possible.
.
[Mh] Termos MeSH primário: Glomerulonefrite por IGA/induzido quimicamente
Intoxicação por Mercúrio/complicações
Nefrose Lipoide/induzido quimicamente
Preparações Clareadoras de Pele/envenenamento
[Mh] Termos MeSH secundário: Adulto
Quelantes/uso terapêutico
Feminino
Glomerulonefrite por IGA/patologia
Glomerulonefrite por IGA/terapia
Hematúria/etiologia
Seres Humanos
Rim/patologia
Rim/ultraestrutura
Intoxicação por Mercúrio/tratamento farmacológico
Nefrose Lipoide/patologia
Nefrose Lipoide/terapia
Síndrome Nefrótica/etiologia
Síndrome Nefrótica/terapia
Proteinúria/etiologia
Indução de Remissão
Preparações Clareadoras de Pele/química
Unitiol/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chelating Agents); 0 (Skin Lightening Preparations); 4076-02-2 (Unithiol)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170602
[Lr] Data última revisão:
170602
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170120
[St] Status:MEDLINE
[do] DOI:10.5414/CN108967



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