Base de dados : MEDLINE
Pesquisa : D27.720.470.280.060 [Categoria DeCS]
Referências encontradas : 200 [refinar]
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[PMID]:28466189
[Au] Autor:Schupp T; Austin T; Eadsforth CV; Bossuyt B; Shen SM; West RJ
[Ad] Endereço:Faculty of Chemical Engineering, Muenster University of Applied Science, Stegerwaldstrasse 39, Steinfurt, 48565, Germany. thomas.schupp@fh-muenster.de.
[Ti] Título:A Review of the Environmental Degradation, Ecotoxicity, and Bioaccumulation Potential of the Low Molecular Weight Polyether Polyol Substances.
[So] Source:Rev Environ Contam Toxicol;244:53-111, 2018.
[Is] ISSN:0179-5953
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:"Polyalkylene glycol" is the name given to a broad class of synthetic organic chemicals which are produced by polymerization of one or more alkylene oxide (epoxide) monomers, such as ethylene oxide (EO) and propylene oxide (PO), with various initiator substances which possess amine or alcohol groups. A generalization of this polymerization reaction is illustrated in Fig. 1.
[Mh] Termos MeSH primário: Misturas Anfolíticas/química
Misturas Anfolíticas/toxicidade
Poluentes Ambientais/química
Poluentes Ambientais/toxicidade
Polímeros/química
Polímeros/toxicidade
[Mh] Termos MeSH secundário: Misturas Anfolíticas/farmacocinética
Animais
Poluentes Ambientais/farmacocinética
Seres Humanos
Polímeros/farmacocinética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Ampholyte Mixtures); 0 (Environmental Pollutants); 0 (Polymers)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1007/398_2017_2


  2 / 200 MEDLINE  
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[PMID]:27874208
[Au] Autor:Shim J; Yoo K; Dutta P
[Ad] Endereço:School of Mechanical Engineering, Yeungnam University, Gyeongsan, Gyeonsanbukdo, South Korea.
[Ti] Título:Steady-state protein focusing in carrier ampholyte based isoelectric focusing: Part I-Analytical solution.
[So] Source:Electrophoresis;38(5):659-666, 2017 03.
[Is] ISSN:1522-2683
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The determination of an analytical solution to find the steady-state protein concentration distribution in IEF is very challenging due to the nonlinear coupling between mass and charge conservation equations. In this study, approximate analytical solutions are obtained for steady-state protein distribution in carrier ampholyte based IEF. Similar to the work of Svensson, the final concentration profile for proteins is assumed to be Gaussian, but appropriate expressions are presented in order to obtain the effective electric field and pH gradient in the focused protein band region. Analytical results are found from iterative solutions of a system of coupled algebraic equations using only several iterations for IEF separation of three plasma proteins: albumin, cardiac troponin I, and hemoglobin. The analytical results are compared with numerically predicted results for IEF, showing excellent agreement. Analytically obtained electric field and ionic conductivity distributions show significant deviation from their nominal values, which is essential in finding the protein focusing behavior at isoelectric points. These analytical solutions can be used to determine steady-state protein concentration distribution for experiment design of IEF considering any number of proteins and ampholytes. Moreover, the model presented herein can be used to find the conductivity, electric field, and pH field.
[Mh] Termos MeSH primário: Misturas Anfolíticas/química
Proteínas Sanguíneas/análise
Focalização Isoelétrica/métodos
[Mh] Termos MeSH secundário: Proteínas Sanguíneas/química
Proteínas Sanguíneas/isolamento & purificação
Condutividade Elétrica
Concentração de Íons de Hidrogênio
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Ampholyte Mixtures); 0 (Blood Proteins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161123
[St] Status:MEDLINE
[do] DOI:10.1002/elps.201600416


  3 / 200 MEDLINE  
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[PMID]:27868220
[Au] Autor:Shim J; Yoo K; Dutta P
[Ad] Endereço:School of Mechanical Engineering, Yeungnam University, Gyeongsan, Gyeonsanbukdo, South Korea.
[Ti] Título:Steady-state protein focusing in carrier ampholyte-based isoelectric focusing: Part II-validation and case studies.
[So] Source:Electrophoresis;38(5):667-676, 2017 03.
[Is] ISSN:1522-2683
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:In this study, we systematically investigate the validity and applicability of an analytical model developed for carrier ampholyte-based isoelectric focusing (IEF). Three different IEF cases are considered in order to evaluate the efficacy of the approximate analytical results by comparison with high-resolution computer simulations. In the first case, three proteins are separated in a narrow pH range (6-9) by using 50 carrier ampholytes. In the second and third cases, the separation of proteins is studied in broad pH range (3-10) IEF by using 100 carrier ampholytes. Results obtained from the approximate analytical models are in very good agreement with the numerical results for IEF separation of cardiac troponin I, albumin, and hemoglobin in both narrow and broad pH ranges. The sensitivity of the analytical model is also tested for different initial mass ratios of proteins to ampholytes. No appreciable differences are observed between the approximate analytical and numerical results within the mass ratio range studied. The effect of a nominal electric field and/or a nominal pH gradient on protein focusing is also examined to demonstrate the effectiveness of the analytical model. Our results indicate that the use of both nominal electric field and pH gradient will result in erroneous peak concentrations for proteins. Finally, we describe the limitations of the approximate analytical solutions.
[Mh] Termos MeSH primário: Misturas Anfolíticas/química
Focalização Isoelétrica/métodos
Proteínas/isolamento & purificação
[Mh] Termos MeSH secundário: Simulação por Computador
Concentração de Íons de Hidrogênio
Proteínas/análise
Proteínas/química
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Ampholyte Mixtures); 0 (Proteins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161122
[St] Status:MEDLINE
[do] DOI:10.1002/elps.201600420


  4 / 200 MEDLINE  
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[PMID]:27699824
[Au] Autor:Takácsi-Nagy A; Kilár F; Thormann W
[Ad] Endereço:Institute of Bioanalysis and Szentágothai Research Center, University of Pécs, Pécs, Hungary.
[Ti] Título:Modeling of formation and prevention of a pure water zone in capillary isoelectric focusing with narrow pH range carrier ampholytes.
[So] Source:Electrophoresis;38(5):677-688, 2017 03.
[Is] ISSN:1522-2683
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:This paper comprises a continuation of computer simulation studies dealing with carrier ampholyte based CIEF in presence of narrow pH gradients. With this technique, amphoteric sample components with pI values outside the pH gradient are migrating isotachophoretically toward the cathode or anode whereas components with pI values within the gradient become focused. In order to understand the processes occurring in presence of the electric field, the behavior of both carrier ampholytes and amphoteric sample components is investigated by computer modeling. Characteristics of two pH unit gradients with end components having pI values at or around 7.00 and conditions that lead to the formation of a water zone at neutrality were investigated. Data obtained reveal that a zone of water is formed in focusing with carrier ampholytes when the applied pH range does not cover the neutral region, ends at pH 7.00 or begins at pH 7.00. The presence of additional amphoteric components that cover the neutrality region prevent water zone formation under current flow. This situation is met in experiments with narrow pH gradients that end or begin around neutrality. Simulation data reveal that no water zone evolves when atmospheric carbon dioxide dissolved in the catholyte causes the migration of carbonic acid (in the form of carbonate and/or hydrogen carbonate ions) from the catholyte through the focusing structure. An electrolyte change in the electrode solution does not have an impact on the focusing part but does change the isotachophoretic pattern migrating behind the leading ion.
[Mh] Termos MeSH primário: Misturas Anfolíticas/química
Eletroforese Capilar/métodos
Focalização Isoelétrica/métodos
[Mh] Termos MeSH secundário: Ácido Carbônico/química
Simulação por Computador
Concentração de Íons de Hidrogênio
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Ampholyte Mixtures); 059QF0KO0R (Water); 463-79-6 (Carbonic Acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161005
[St] Status:MEDLINE
[do] DOI:10.1002/elps.201600314


  5 / 200 MEDLINE  
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[PMID]:25682176
[Au] Autor:Edwards TL; Groppe M; Jolly JK; Downes SM; MacLaren RE
[Ad] Endereço:Nuffield Laboratory of Ophthalmology, John Radcliffe Hospital, Oxford, UK; Oxford Eye Hospital and Oxford University Hospitals, NHS Trust NIHR Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK. Electronic address: thomas.edwards@ndcn.ox.ac.uk.
[Ti] Título:Correlation of retinal structure and function in choroideremia carriers.
[So] Source:Ophthalmology;122(6):1274-6, 2015 Jun.
[Is] ISSN:1549-4713
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Coroideremia/fisiopatologia
Doenças Genéticas Ligadas ao Cromossomo X/fisiopatologia
Retina/fisiopatologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Misturas Anfolíticas
Coroideremia/genética
Ilhas de CpG/genética
Feminino
Doenças Genéticas Ligadas ao Cromossomo X/genética
Heterozigoto
Seres Humanos
Masculino
Meia-Idade
Fenótipo
Limiar Sensorial
Acuidade Visual/fisiologia
Testes de Campo Visual
Campos Visuais/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Ampholyte Mixtures)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:150526
[Lr] Data última revisão:
150526
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150216
[St] Status:MEDLINE


  6 / 200 MEDLINE  
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[PMID]:25358859
[Au] Autor:Kristl T; Stutz H
[Ad] Endereço:Division of Chemistry and Bioanalytics, Department of Molecular Biology, University of Salzburg, Salzburg, Austria.
[Ti] Título:Comparison of different mobilization strategies for capillary isoelectric focusing of ovalbumin variants.
[So] Source:J Sep Sci;38(1):148-56, 2015 Jan.
[Is] ISSN:1615-9314
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:One pressure and three chemical mobilization strategies have been optimized and tested for two-step capillary isoelectric focusing with ultraviolet detection with simultaneous refining of the composition of carrier ampholytes as well as of anodic and cathodic spacers. The comparison of individual mobilization strategies was performed on basis of model proteins and peptides covering a pI range of 4.1-10.0, finally targeting an acidic major food allergen, that is, ovalbumin. Resolution was improved by combining Pharmalyte 3-10 with Pharmalyte 5-6 with concentration adjustment of carrier ampholytes and the anodic and cathodic spacer, respectively. Analytes within pI 5-6 but not ovalbumin were prone to artificial peak duplication under selected capillary isoelectric focusing conditions due to retardation during focusing. l-Arginine and iminodiacetic acid were included as spacer to prevent drifts of the pH gradient and optionally block the distal capillary part. l-Arginine affected the baseline in the acidic regime in some instances by introducing irregularities that interfered with ovalbumin. Cathodic mobilization with an acidic zwitterion provided the best selectivity for ovalbumin and was successfully applied for the characterization of three commercial products of ovalbumin, revealing differences between the respective profiles. Up to 12 different fractions situated between pI 4.51 and 4.72 could be addressed.
[Mh] Termos MeSH primário: Focalização Isoelétrica/métodos
Ovalbumina/química
[Mh] Termos MeSH secundário: Misturas Anfolíticas/química
Focalização Isoelétrica/instrumentação
Força Próton-Motriz
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ampholyte Mixtures); 9006-59-1 (Ovalbumin)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:150106
[Lr] Data última revisão:
150106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141101
[St] Status:MEDLINE
[do] DOI:10.1002/jssc.201400890


  7 / 200 MEDLINE  
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[PMID]:24178632
[Au] Autor:Chen Y; Wang T; Ma J; Liang Z; Chen M; Fang J; Gao H; Zhang L; Zhang Y
[Ad] Endereço:Xiangshan Entry-Exit Inspection and Quarantine, Xiangshan, China.
[Ti] Título:Application of an ampholine-functionalized hybrid organic-inorganic silica material for the SPE of aromatic amines.
[So] Source:J Sep Sci;37(1-2):143-50, 2014 Jan.
[Is] ISSN:1615-9314
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:An SPE cartridge based on an ampholine-functionalized hybrid organic-inorganic silica sorbent has been adopted for the analysis of aromatic amines including 4-aminobiphenyl, benzidine, 2-naphthylamine, p-chloroaniline, 2,4,5-trimethylaniline, and 3,3'-dichlorobenzidine. Crucial variables governing the extraction efficiency of the material such as the pH of sample, sample loading volume, solvent used for elution, and elution volume have been thoroughly optimized. The adsorption capacities for the six aromatic amines ranged from 0.17 to 1.82 µg/mg. The recoveries of aromatic amines spiked in textile samples ranged from 78.9 to 103.0%, with RSDs of 1.1-11.9% (n = 3). Moreover, the extraction efficiency of the ampholine-functionalized hybrid organic-inorganic silica sorbent was at least comparable with that of Oasis WCX.
[Mh] Termos MeSH primário: Aminas/isolamento & purificação
Misturas Anfolíticas/isolamento & purificação
Dióxido de Silício/química
Extração em Fase Sólida/métodos
[Mh] Termos MeSH secundário: Adsorção
Aminas/química
Misturas Anfolíticas/química
Extração em Fase Sólida/instrumentação
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amines); 0 (Ampholyte Mixtures); 7631-86-9 (Silicon Dioxide)
[Em] Mês de entrada:1407
[Cu] Atualização por classe:140113
[Lr] Data última revisão:
140113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131102
[St] Status:MEDLINE
[do] DOI:10.1002/jssc.201300964


  8 / 200 MEDLINE  
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[PMID]:24166014
[Au] Autor:Choy DY; Creagh AL; Haynes C
[Ad] Endereço:Department of Chemical and Biological Engineering, Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada, V6T 1Z4.
[Ti] Título:Improved isoelectric focusing chromatography on strong anion exchange media via a new model that custom designs mobile phases using simple buffers.
[So] Source:Biotechnol Bioeng;111(3):552-64, 2014 Mar.
[Is] ISSN:1097-0290
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Isoelectric chromatofocusing (ICF), a mode of chromatography by which proteins are separated based on changes in their charge state with pH, is widely used at analytical scales and finding increasing interest in biologics manufacturing due to its exceptional resolving power. Here, a method is described for using simple monoprotic and diprotic buffers to create stable mobile phases for sample loading on a strong anion exchange column and for achieving an elution pH gradient of desired shape covering any pH range from pH 10.0 to 3. The buffers used are selected to satisfy cost constraints, and to permit facile detection of eluted biologics by UV spectroscopy and mass spectrometry. The method exploits a new model described here that combines multiple-chemical and adsorption-equilibria theory to enable in silico tailoring of elution pH profiles using mixtures of these simple buffers. It is shown to provide a versatile platform for optimizing and conducting ICF of protein mixtures on strong anion exchange media.
[Mh] Termos MeSH primário: Cromatografia por Troca Iônica/métodos
Resinas de Troca Iônica
Focalização Isoelétrica/métodos
[Mh] Termos MeSH secundário: Misturas Anfolíticas
Tampões (Química)
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ampholyte Mixtures); 0 (Buffers); 0 (Ion Exchange Resins)
[Em] Mês de entrada:1409
[Cu] Atualização por classe:140121
[Lr] Data última revisão:
140121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131030
[St] Status:MEDLINE
[do] DOI:10.1002/bit.25122


  9 / 200 MEDLINE  
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[PMID]:24165899
[Au] Autor:Yoo K; Shim J; Liu J; Dutta P
[Ad] Endereço:School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, USA.
[Ti] Título:Efficient algorithm for simulation of isoelectric focusing.
[So] Source:Electrophoresis;35(5):638-45, 2014 Mar.
[Is] ISSN:1522-2683
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:IEF simulation is an effective tool to investigate the transport phenomena and separation performance as well as to design IEF microchip. However, multidimensional IEF simulations are computationally intensive as one has to solve a large number of mass conservation equations for ampholytes to simulate a realistic case. In this study, a parallel scheme for a 2D IEF simulation is developed to reduce the computational time. The calculation time for each equation is analyzed to identify which procedure is suitable for parallelization. As expected, simultaneous solution of mass conservation equations of ampholytes is identified as the computational hot spot, and the computational time can be significantly reduced by parallelizing the solution procedure for that. Moreover, to optimize the computing time, electric potential behavior during transient state is investigated. It is found that for a straight channel the transient variation of electric potential along the channel is negligible in a narrow pH range (5∼8) IEF. Thus the charge conservation equation is solved for the first time step only, and the electric potential obtain from that is used for subsequent calculations. IEF simulations are carried out using this algorithm for separation of cardiac troponin I from serum albumin in a pH range of 5-8 using 192 biprotic ampholytes. Significant reduction in simulation time is achieved using the parallel algorithm. We also study the effect of number of ampholytes to form the pH gradient and its effect in the focusing and separation behavior of cardiac troponin I and albumin. Our results show that, at the completion of separation phase, the pH profile is stepwise for lower number of ampholytes, but becomes smooth as the number of ampholytes increases. Numerical results also show that higher protein concentration can be obtained using higher number of ampholytes.
[Mh] Termos MeSH primário: Algoritmos
Tampões (Química)
Focalização Isoelétrica/métodos
[Mh] Termos MeSH secundário: Misturas Anfolíticas
Simulação por Computador
Concentração de Íons de Hidrogênio
Computação Matemática
Força Próton-Motriz
Albumina Sérica/isolamento & purificação
Troponina/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Ampholyte Mixtures); 0 (Buffers); 0 (Serum Albumin); 0 (Troponin)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:140305
[Lr] Data última revisão:
140305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131030
[St] Status:MEDLINE
[do] DOI:10.1002/elps.201300310


  10 / 200 MEDLINE  
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[PMID]:23974001
[Au] Autor:Sankar RM; Seeni Meera KM; Samanta D; Jithendra P; Mandal AB; Jaisankar SN
[Ad] Endereço:Polymer Division, Council of Scientific and Industrial Research (CSIR) - Central Leather Research Institute (CLRI), Adyar, Chennai 600020, Tamil Nadu, India.
[Ti] Título:The pH-sensitive polyampholyte nanogels: inclusion of carbon nanotubes for improved drug loading.
[So] Source:Colloids Surf B Biointerfaces;112:120-7, 2013 Dec 01.
[Is] ISSN:1873-4367
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:We report a simple and facile method to prepare a novel pH sensitive polyampholyte nanogel by copolymerizing vinylimidazole (VIM) with acrylic acid (AA) using functionalized single-walled carbon nanotubes (f-SWCNTs) (as reinforcing material) and cyanuric chloride via an intermolecular quaternization reaction. The polyampholyte nanogels have been characterized by various microscopic and spectroscopic methods. These studies reveal that incorporation of nanotubes in cross-linked copolymer of poly(vinylimidazole-co-acrylic acid) (PVI-co-AA) form polyampholyte nanogel with enhanced physical properties. The thermal experiments show that the introduction of f-SWCNTs into PVI-co-AA has significant impact on the thermal stability of nanogels. The rheological study showed that the nanogel is more viscoelastic than native gel. MTT assay indicates that the prepared polyampholyte gels possess biocompatibility and cell viability. The nanogel is also useful material to load water-soluble drug such as promethazine hydrochloride. The releasing profile of the drug from the nanogel clearly shows the pH-sensitive property of the material.
[Mh] Termos MeSH primário: Misturas Anfolíticas/química
Sistemas de Liberação de Medicamentos
Hidrogéis
Nanotubos de Carbono/química
[Mh] Termos MeSH secundário: Portadores de Fármacos/química
Estabilidade de Medicamentos
Temperatura Alta
Concentração de Íons de Hidrogênio
Imidazolinas/química
Espectroscopia de Ressonância Magnética
Microscopia Eletrônica de Varredura
Nanotubos de Carbono/ultraestrutura
Polivinil/química
Prometazina/administração & dosagem
Reologia
Espectrofotometria
Espectroscopia de Infravermelho com Transformada de Fourier
Análise Espectral Raman
Viscosidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Ampholyte Mixtures); 0 (Drug Carriers); 0 (Hydrogels); 0 (Imidazolines); 0 (Nanotubes, Carbon); 0 (Polyvinyls); 0 (polyvinylimidazoline); FF28EJQ494 (Promethazine)
[Em] Mês de entrada:1407
[Cu] Atualização por classe:131104
[Lr] Data última revisão:
131104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130827
[St] Status:MEDLINE



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