Base de dados : MEDLINE
Pesquisa : D27.720.777 [Categoria DeCS]
Referências encontradas : 1328 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 133 ir para página                         

  1 / 1328 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28596327
[Au] Autor:Phadnis N
[Ad] Endereço:Department of Biology, University of Utah, UT 84112, USA. nitin.phadnis@utah.edu.
[Ti] Título:Poisons, antidotes, and selfish genes.
[So] Source:Science;356(6342):1013, 2017 06 09.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Antídotos
Venenos
[Mh] Termos MeSH secundário: Seres Humanos
Envenenamento
Sequências Repetitivas de Ácido Nucleico
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Nm] Nome de substância:
0 (Antidotes); 0 (Poisons)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE
[do] DOI:10.1126/science.aan6119


  2 / 1328 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28428144
[Au] Autor:Koshiol J; Gao YT; Dean M; Egner P; Nepal C; Jones K; Wang B; Rashid A; Luo W; Van Dyke AL; Ferreccio C; Malasky M; Shen MC; Zhu B; Andersen JB; Hildesheim A; Hsing AW; Groopman J
[Ad] Endereço:Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland. Electronic address: koshiolj@mail.nih.gov.
[Ti] Título:Association of Aflatoxin and Gallbladder Cancer.
[So] Source:Gastroenterology;153(2):488-494.e1, 2017 Aug.
[Is] ISSN:1528-0012
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND & AIMS: Aflatoxin, which causes hepatocellular carcinoma, may also cause gallbladder cancer. We investigated whether patients with gallbladder cancer have higher exposure to aflatoxin than patients with gallstones. METHODS: We measured aflatoxin B (AFB )-lysine adducts in plasma samples from the Shanghai Biliary Tract Cancer case-control study, conducted from 1997 through 2001. We calculated age- and sex-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) and the population-attributable fraction for 209 patients with gallbladder cancer and gallstones vs 250 patients with gallstones without cancer (controls). In 54 patients with gallbladder cancer, tumor tissue was examined for the R249S mutation in TP53, associated with aflatoxin exposure, through targeted sequencing. RESULTS: The AFB -lysine adduct was detected in 67 (32%) of 209 patients with gallbladder cancer and 37 (15%) of the 250 controls (χ P < .0001), almost threefold more patients with gallbladder cancer than controls (OR, 2.71; 95% CI, 1.70-4.33). Among participants with detectable levels of AFB -lysine, the median level of AFB -lysine was 5.4 pg/mg in those with gallbladder cancer, compared with 1.2 pg/mg in controls. For patients in the fourth quartile of AFB -lysine level vs the first quartile, the OR for gallbladder cancer was 7.61 (95% CI, 2.01-28.84). None of the 54 gallbladder tumors sequenced were found to have the R249S mutation in TP53. The population-attributable fraction for cancer related to aflatoxin was 20% (95% CI, 15%-25%). CONCLUSIONS: In a case-control study of patients with gallbladder cancer and gallstones vs patients with gallstones without cancer, we associated exposure to aflatoxin (based on plasma level of AFB -lysine) with gallbladder cancer. Gallbladder cancer does not appear associate with the R249S mutation in TP53. If aflatoxin is a cause of gallbladder cancer, it may have accounted for up to 20% of the gallbladder cancers in Shanghai, China, during the study period, and could account for an even higher proportion in high-risk areas. If our findings are verified, reducing aflatoxin exposure might reduce the incidence of gallbladder cancer.
[Mh] Termos MeSH primário: Aflatoxina B1/sangue
Aflatoxinas/toxicidade
Neoplasias da Vesícula Biliar/induzido quimicamente
Cálculos Biliares/complicações
Lisina/sangue
Venenos/toxicidade
[Mh] Termos MeSH secundário: Adulto
Idoso
Estudos de Casos e Controles
Distribuição de Qui-Quadrado
China
Feminino
Neoplasias da Vesícula Biliar/sangue
Neoplasias da Vesícula Biliar/genética
Neoplasias da Vesícula Biliar/patologia
Cálculos Biliares/sangue
Genes p53
Seres Humanos
Masculino
Meia-Idade
Mutação
Fatores de Risco
Proteína Supressora de Tumor p53/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aflatoxins); 0 (Poisons); 0 (TP53 protein, human); 0 (Tumor Suppressor Protein p53); 0 (aflatoxin B1-lysine adduct); 9N2N2Y55MH (Aflatoxin B1); K3Z4F929H6 (Lysine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170422
[St] Status:MEDLINE


  3 / 1328 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28397754
[Au] Autor:Halasa M; Maciejewska D; Baskiewicz-Halasa M; Machalinski B; Safranow K; Stachowska E
[Ad] Endereço:Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Szczecin 70-204, Poland. maciupam@op.pl.
[Ti] Título:Oral Supplementation with Bovine Colostrum Decreases Intestinal Permeability and Stool Concentrations of Zonulin in Athletes.
[So] Source:Nutrients;9(4), 2017 Apr 08.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Increased intestinal permeability has been implicated in various pathologies, has various causes, and can develop during vigorous athletic training. Colostrum bovinum is a natural supplement with a wide range of supposed positive health effects, including reduction of intestine permeability. We assessed influence of colostrum supplementation on intestinal permeability related parameters in a group of 16 athletes during peak training for competition. This double-blind placebo-controlled study compared supplementation for 20 days with 500 mg of colostrum bovinum or placebo (whey). Gut permeability status was assayed by differential absorption of lactulose and mannitol (L/M test) and stool zonulin concentration. Baseline L/M tests found that six of the participants (75%) in the colostrum group had increased intestinal permeability. After supplementation, the test values were within the normal range and were significantly lower than at baseline. The colostrum group Δ values produced by comparing the post-intervention and baseline results were also significantly lower than the placebo group Δ values. The differences in stool zonulin concentration were smaller than those in the L/M test, but were significant when the Δ values due to intervention were compared between the colostrum group and the placebo group. Colostrum bovinum supplementation was safe and effective in decreasing of intestinal permeability in this series of athletes at increased risk of its elevation.
[Mh] Termos MeSH primário: Produtos Biológicos/uso terapêutico
Colostro/química
Suplementos Nutricionais
Fármacos Gastrointestinais/uso terapêutico
Gastroenteropatias/prevenção & controle
Mucosa Intestinal/metabolismo
Estresse Fisiológico
[Mh] Termos MeSH secundário: Adulto
Animais
Atletas
Produtos Biológicos/efeitos adversos
Bovinos
Permeabilidade da Membrana Celular/efeitos dos fármacos
Toxina da Cólera/análise
Toxina da Cólera/antagonistas & inibidores
Toxina da Cólera/metabolismo
Toxina da Cólera/toxicidade
Estudos Cross-Over
Suplementos Nutricionais/efeitos adversos
Método Duplo-Cego
Fezes/química
Liofilização
Fármacos Gastrointestinais/efeitos adversos
Gastroenteropatias/induzido quimicamente
Gastroenteropatias/metabolismo
Gastroenteropatias/fisiopatologia
Seres Humanos
Absorção Intestinal/efeitos dos fármacos
Mucosa Intestinal/efeitos dos fármacos
Mucosa Intestinal/fisiologia
Mucosa Intestinal/fisiopatologia
Masculino
Artes Marciais
Venenos/análise
Venenos/química
Venenos/metabolismo
Venenos/toxicidade
Polônia
Toxicocinética
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Biological Products); 0 (Gastrointestinal Agents); 0 (Poisons); 0 (zonulin); 9012-63-9 (Cholera Toxin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE


  4 / 1328 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28280716
[Au] Autor:An Y; Shi X; Tang X; Wang Y; Shen F; Zhang Q; Wang C; Jiang M; Liu M; Yu L
[Ad] Endereço:Key Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, First Hospital of Jilin University, College of Veterinary Medicine and College of Animal Science, Jilin University Changchun, China.
[Ti] Título:Aflatoxin B1 Induces Reactive Oxygen Species-Mediated Autophagy and Extracellular Trap Formation in Macrophages.
[So] Source:Front Cell Infect Microbiol;7:53, 2017.
[Is] ISSN:2235-2988
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Aflatoxins are a group of highly toxic mycotoxins with high carcinogenicity that are commonly found in foods. Aflatoxin B1 (AFB1) is the most toxic member of the aflatoxin family. A recent study reported that AFB1 can induce autophagy, but whether AFB1 can induce extracellular traps (ETs) and the relationships among innate immune responses, reactive oxygen species (ROS), and autophagy and the ETs induced by AFB1 remain unknown. Here, we demonstrated that AFB1 induced a complete autophagic process in macrophages (MΦ) (THP-1 cells and RAW264.7 cells). In addition, AFB1 induced the generation of MΦ ETs (METs) in a dose-dependent manner. In particular, the formation of METs significantly reduced the AFB1 content. Further analysis using specific inhibitors showed that the inhibition of either autophagy or ROS prevented MET formation caused by AFB1, indicating that autophagy and ROS were required for AFB1-induced MET formation. The inhibition of ROS prevented autophagy, indicating that ROS generation occurred upstream of AFB1-induced autophagy. Taken together, these data suggest that AFB1 induces ROS-mediated autophagy and ETs formation and an M1 phenotype in MΦ.
[Mh] Termos MeSH primário: Aflatoxina B1/metabolismo
Autofagia
Armadilhas Extracelulares/metabolismo
Macrófagos/efeitos dos fármacos
Macrófagos/imunologia
Espécies Reativas de Oxigênio/metabolismo
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Seres Humanos
Camundongos
Venenos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Poisons); 0 (Reactive Oxygen Species); 9N2N2Y55MH (Aflatoxin B1)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE
[do] DOI:10.3389/fcimb.2017.00053


  5 / 1328 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28243958
[Au] Autor:Dunham NR; Peper ST; Downing CD; Kendall RJ
[Ad] Endereço:The Wildlife Toxicology Laboratory, The Institute of Environmental and Human Health, Texas Tech University, Box 41163, Lubbock, Texas, 79409-1162, USA.
[Ti] Título:Aflatoxin contamination in corn sold for wildlife feed in texas.
[So] Source:Ecotoxicology;26(4):516-520, 2017 May.
[Is] ISSN:1573-3017
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Supplemental feeding with corn to attract and manage deer is a common practice throughout Texas. Other species, including northern bobwhites (Colinus virginianus), are commonly seen feeding around supplemental deer feeders. In many cases, supplemental feeding continues year-round so feed supply stores always have supplemental corn in stock. Fluctuating weather and improper storage of corn can lead to and/or amplify aflatoxin contamination. Due to the recent decline of bobwhites throughout the Rolling Plains ecoregion of Texas, there has been interest in finding factors such as toxins that could be linked to their decline. In this study, we purchased and sampled supplemental corn from 19 locations throughout this ecoregion to determine if aflatoxin contamination was present in individual bags prior to being dispersed to wildlife. Of the 57 bags sampled, 33 bags (approximately 58%) contained aflatoxin with a bag range between 0.0-19.91 parts per billion (ppb). Additionally, three metal and three polypropylene supplemental feeders were each filled with 45.4 kg of triple cleaned corn and placed in an open field to study long-term aflatoxin buildup. Feeders were sampled every 3 months from November 2013-November 2014. Average concentration of aflatoxin over the year was 4.08 ± 2.53 ppb (±SE) in metal feeders, and 1.43 ± 0.89 ppb (±SE) in polypropylene feeders. The concentration of aflatoxins is not affected by the type of feeder (metal vs polypropylene), the season corn was sampled, and the location in the feeder (top, middle, bottom) where corn is sampled. It is unlikely that corn used in supplemental feeders is contributing to the bobwhite decline due to the low levels of aflatoxin found in purchased corn and long-term storage of corn used in supplemental feeders.
[Mh] Termos MeSH primário: Aflatoxinas/análise
Ração Animal/análise
Contaminação de Alimentos/análise
Venenos/análise
[Mh] Termos MeSH secundário: Animais
Texas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aflatoxins); 0 (Poisons)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170301
[St] Status:MEDLINE
[do] DOI:10.1007/s10646-017-1782-7


  6 / 1328 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28187674
[Au] Autor:Serrano-Rojas SJ; Whitworth A; Villacampa J; May RV; Gutiérrez RC; Padial JM; Chaparro JC
[Ad] Endereço:The Crees Foundation, Mariscal Gamarra, B-5, Zona-1, 2da Etapa, Cusco, Perú. Universidad Nacional San Antonio Abad del Cusco (UNSAAC), Av. de la Cultura, Nro. 733, Cusco - Perú.. shirley.serrano25@gmail.com.
[Ti] Título:A new species of poison-dart frog (Anura: Dendrobatidae) from Manu province, Amazon region of southeastern Peru, with notes on its natural history, bioacoustics, phylogenetics, and recommended conservation status.
[So] Source:Zootaxa;4221(1):zootaxa.4221.1.3, 2017 Jan 16.
[Is] ISSN:1175-5334
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:We describe and name a new species of poison-dart frog from the Amazonian slopes of the Andes in Manu Province, Madre de Dios Department, Peru; specifically within the Amarakaeri Communal Reserve and the buffer zone of Manu National Park. Ameerega shihuemoy sp. nov. is supported by a unique combination of characters: black dorsum with cream to light orange dorsolateral lines, blue belly reticulated with black, and the lack of axillary, thigh and calf flash marks. Within Ameerega, it shares the general appearance of A. altamazonica, A. boliviana, A. hahneli, A. ignipedis, A. petersi, A. picta, A. pongoensis, A. pulchripecta, A. simulans, A. smaragdina, and A. yungicola; each possessing a granular black to brown dorsum, a light labial bar, a conspicuous dorsolateral line running from the snout to the groin, and a metallic blue belly and underside of arms and hind limbs. From most of these species it can be distinguished by lacking flash marks on the axillae, thighs, and calves (absent in only A. boliviana and A. smaragdina, most A. petersi, and some A. pongoensis), by having bright cream to orange dorsolateral stripes (white, intense yellow, or green in all other species, with the exception of A. picta), and by its blue belly reticulated with black (bluish white and black in A. boliviana, green and blue with black marbling in A. petersi, and green and blue lacking black marbling in A. smaragdina). Its mating call also shows clear differences to morphologically similar species, with a lower note repetition rate, longer space between calls, and higher fundamental and dominant frequencies. Phylogenetic analyses based on the 16S mitochondrial rRNA fragment also support the distinctiveness of the new species and suggest that A. shihuemoy is most closely related to Ameerega macero, A. altamazonica, A. rubriventris, and two undescribed species (Ameerega sp. from Porto Walter, Acre, Brazil, and Ameerega sp. from Ivochote, Cusco, Peru). Genetically, the new species is most similar to the sympatric A. macero, from which it clearly differs in characteristics of its advertisement call and coloration. The new species is found near rocky streams during the dry season and near temporary water bodies during the rainy season. Tadpoles are found in lentic water along streams, or in shallow, slow-moving streams. Given its small geographic range, we recommend that A. shihuemoy should be considered 'Near threatened' (NT) according to IUCN Red List criteria.
[Mh] Termos MeSH primário: Anuros
Filogenia
Vocalização Animal
[Mh] Termos MeSH secundário: Animais
Brasil
Peru
Venenos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Poisons)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170801
[Lr] Data última revisão:
170801
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170212
[St] Status:MEDLINE
[do] DOI:10.11646/zootaxa.4221.1.3


  7 / 1328 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28177231
[Au] Autor:Ashauer R; O'Connor I; Escher BI
[Ad] Endereço:Department of Environmental Toxicology, Eawag - Swiss Federal Institute of Aquatic Science and Technology , 8600 Dübendorf, Switzerland.
[Ti] Título:Toxic Mixtures in Time-The Sequence Makes the Poison.
[So] Source:Environ Sci Technol;51(5):3084-3092, 2017 Mar 07.
[Is] ISSN:1520-5851
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:"The dose makes the poison". This principle assumes that once a chemical is cleared out of the organism (toxicokinetic recovery), it no longer has any effect. However, it overlooks the other process of re-establishing homeostasis, toxicodynamic recovery, which can be fast or slow depending on the chemical. Therefore, when organisms are exposed to two toxicants in sequence, the toxicity can differ if their order is reversed. We test this hypothesis with the freshwater crustacean Gammarus pulex and four toxicants that act on different targets (diazinon, propiconazole, 4,6-dinitro-o-cresol, 4-nitrobenzyl chloride). We found clearly different toxicity when the exposure order of two toxicants was reversed, while maintaining the same dose. Slow toxicodynamic recovery caused carry-over toxicity in subsequent exposures, thereby resulting in a sequence effect-but only when toxicodynamic recovery was slow relative to the interval between exposures. This suggests that carry-over toxicity is a useful proxy for organism fitness and that risk assessment methods should be revised as they currently could underestimate risk. We provide the first evidence that carry-over toxicity occurs among chemicals acting on different targets and when exposure is several days apart. It is therefore not only the dose that makes the poison but also the exposure sequence.
[Mh] Termos MeSH primário: Anfípodes/efeitos dos fármacos
Diazinon/toxicidade
[Mh] Termos MeSH secundário: Animais
Substâncias Perigosas
Venenos
Medição de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hazardous Substances); 0 (Poisons); YUS1M1Q929 (Diazinon)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE
[do] DOI:10.1021/acs.est.6b06163


  8 / 1328 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28079089
[Au] Autor:Owens B
[Ti] Título:Behind New Zealand's wild plan to purge all pests.
[So] Source:Nature;541(7636):148-150, 2017 01 11.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Ecologia
Espécies Introduzidas
Controle de Pragas/métodos
Pesquisa
[Mh] Termos MeSH secundário: Agricultura
Animais
Sistemas CRISPR-Cas/genética
DNA Mitocondrial/genética
Ecologia/economia
Espécies Introduzidas/economia
Espécies Introduzidas/tendências
Camundongos
Nova Zelândia
Controle de Pragas/economia
Controle de Pragas/instrumentação
Praguicidas/toxicidade
Venenos/toxicidade
Dinâmica Populacional
Comportamento Predatório
Ratos
Pesquisa/economia
Motilidade Espermática/genética
Trichosurus/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Mitochondrial); 0 (Pesticides); 0 (Poisons)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170113
[St] Status:MEDLINE
[do] DOI:10.1038/541148a


  9 / 1328 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:28072929
[Au] Autor:Weber LS
[Ad] Endereço:Nil.
[Ti] Título:Correctly name your poison.
[So] Source:Anaesth Intensive Care;45(1):11, 2017 01.
[Is] ISSN:0310-057X
[Cp] País de publicação:Australia
[La] Idioma:eng
[Mh] Termos MeSH primário: Venenos
[Mh] Termos MeSH secundário: Terminologia como Assunto
[Pt] Tipo de publicação:EDITORIAL
[Nm] Nome de substância:
0 (Poisons)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170111
[St] Status:MEDLINE


  10 / 1328 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27924689
[Au] Autor:Toletone A; Voltolini S; Passalacqua G; Dini G; Bignardi D; Minale P; Massa E; Signori A; Troise C; Durando P
[Ad] Endereço:a Department of Health Sciences , Postgraduate School in Occupational Medicine and Occupational Medicine Unit, IRCCS AOU San Martino-IST, University of Genoa , Genoa , Italy.
[Ti] Título:Hymenoptera venom allergy in outdoor workers: Occupational exposure, clinical features and effects of allergen immunotherapy.
[So] Source:Hum Vaccin Immunother;13(2):477-483, 2017 Feb.
[Is] ISSN:2164-554X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To describe (i) the clinical characteristics of workers, exposed to hymenoptera stings, with an ascertained diagnosis of Hymenoptera Venom Allergy (HVA), (ii) the specific role of occupational exposure, (iii) the effect of Venom Immunotherapy (VIT) in reducing the severity of allergic episodes in workers exposed to repeated stings of hymenoptera, and (iv) the management of the occupational consequences caused by allergic reactions due to hymenoptera stings. METHODS: Between 2000 and 2013 an observational study, including patients referred to the regional reference hospital of Liguria, Italy, with an ascertained diagnosis of HVA and treated with VIT, was performed. A structured questionnaire was administered to all patients to investigate the occupational features of allergic reactions. These were graded according to standard systems in patients at the first episode, and after re-stings, during VIT. RESULTS: One-hundred and 8four out of the 202 patients referred had a complete data set. In 32 (17.4%) patients, the allergic reaction occurred during work activities performed outdoor. Of these, 31.2% previously stung by hymenoptera at work, and receiving VIT, were re-stung during occupational activity. The grades of reaction developed under VIT treatment resulted clinically less severe than of those occurred at the first sting (p-value = 0.031). CONCLUSION: Our findings confirmed the clinical relevance of HVA, and described its occupational features in outdoor workers with sensitization, stressing the importance of an early identification and proper management of the professional categories recognized at high risk of hymenoptera stings. The Occupational Physician should be supported by other specialists to recommend appropriate diagnostic procedures and the prescription of VIT, which resulted an effective treatment for the prevention of episodes of severe reactions in workers with a proven HVA.
[Mh] Termos MeSH primário: Dessensibilização Imunológica/métodos
Himenópteros/patogenicidade
Hipersensibilidade/epidemiologia
Hipersensibilidade/terapia
Exposição Ocupacional
Peçonhas/imunologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Animais
Criança
Feminino
Seres Humanos
Itália/epidemiologia
Masculino
Meia-Idade
Venenos/imunologia
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Poisons); 0 (Venoms)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161208
[St] Status:MEDLINE
[do] DOI:10.1080/21645515.2017.1264748



página 1 de 133 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde