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  1 / 46310 MEDLINE  
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[PMID]:29367485
[Au] Autor:Umigai N; Murakami K; Shimizu R; Takeda R; Azuma T
[Ad] Endereço:Riken Vitamin Co., Ltd.
[Ti] Título:Safety Evaluation and Plasma Carotenoid Accumulation in Healthy Adult Subjects after 12 Weeks of Paprika Oleoresin Supplementation.
[So] Source:J Oleo Sci;67(2):225-234, 2018 Feb 01.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Paprika oleoresin is obtained by solvent extraction from Capsicum annuum L. fruits and contains multiple carotenoids, such as capsanthin, ß-carotene, zeaxanthin, and ß-cryptoxanthin, which are considered protective against various diseases. Herein, we investigated the effect of paprika oleoresin supplementation on plasma carotenoid accumulation and evaluated the safety of the oleoresin. We used a double-blinded, placebo-controlled comparative clinical study design and tested the effects of varying doses in healthy adult subjects. In total, 33 subjects were randomly divided into three groups to take capsules containing 0, 20, or 100 mg of paprika oleoresin daily for 12 consecutive weeks. Plasma carotenoid concentrations were measured at 0, 4, 8, and 12 weeks, and the safety of paprika oleoresin capsules was investigated using analyses of blood biochemistry, hematology, and urine contents. In these experiments, ß-cryptoxanthin and zeaxanthin dose-dependently accumulated in plasma within the dose range of the study over 12 consecutive weeks of paprika oleoresin supplementation. Moreover, ß-cryptoxanthin accumulated to higher levels than the other paprika oleoresin carotenoids. In contrast, capsanthin was not detected in plasma before or during the 12-week treatment period. Finally, no adverse events were associated with intake of paprika oleoresin (20 and 100 mg/day) in safety evaluations. Paprika oleoresin is a suitable source of carotenoids, especially ß-cryptoxanthin.
[Mh] Termos MeSH primário: Capsicum/química
Carotenoides/sangue
Suplementos Nutricionais
Extratos Vegetais/administração & dosagem
Extratos Vegetais/isolamento & purificação
[Mh] Termos MeSH secundário: beta-Criptoxantina/sangue
Suplementos Nutricionais/efeitos adversos
Relação Dose-Resposta a Droga
Método Duplo-Cego
Extratos Vegetais/efeitos adversos
Distribuição Aleatória
Segurança
Solventes
Fatores de Tempo
Zeaxantinas/sangue
[Pt] Tipo de publicação:CLINICAL STUDY; COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Beta-Cryptoxanthin); 0 (Plant Extracts); 0 (Solvents); 0 (Zeaxanthins); 0 (oleoresins); 36-88-4 (Carotenoids)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess17155


  2 / 46310 MEDLINE  
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[PMID]:29367484
[Au] Autor:Yamamoto Y; Yoshida H; Nagai T; Hara S
[Ad] Endereço:Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima.
[Ti] Título:Preparation of Chiral Triacylglycerols, sn-POO and sn-OOP, via Lipase-mediated Acidolysis Reaction.
[So] Source:J Oleo Sci;67(2):207-214, 2018 Feb 01.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:It is well known that lipases are useful tools for preparing various structured triacylglycerols (TAGs). However, the lipase-mediated preparation of chiral TAGs has never been reported. This study aimed to prepare chiral TAGs (viz., 1-palmitoyl-2,3-dioleoyl-sn-glycerol (sn-POO) or 1,2-dioleoyl-3-palmitoyl-sn-glycerol (sn-OOP)) via lipase mediated acidolysis, using triolein (TO) and palmitic acid (P) as substrates. Three commercially available lipases (viz., Lipozyme RM-IM , Lipozyme TL-IM , and Lipase OF ) were used. Lipozyme RM-IM resulted in an increase 1P-2O (sn-POO + sn-OOP + 1,3-dioleoyl-2-palmitoyl-sn-glycerol) content with reaction time, which plateaued at 2~24 h (max. yield 47.1% at 4 h). The highest sn-POO/sn-OOP ratio of ca. 9 was obtained at 0.25 h, and the rate got close to 1 with reaction time (sn-POO/sn-OOP = 1.3 at 24 h). Lipozyme TL-IM resulted in a lower 1P-2O synthesis rate than Lipozyme RM-IM , where its highest sn-POO/sn-OOP ratio of ca. 2 was obtained at 0.25 h and did not vary much further with reaction time. In the case of Lipase OF , its reaction rate for 1P-2O synthesis was lower than that of the other two lipases, and the highest sn-POO/sn-OOP ratio of ca. 1.4 was obtained at 0.5 h, reaching closer to 1 with a longer reaction time. Reaction solvents (viz., hexane, acetone, and benzene) also affected the 1P-2O preparation, where the highest 1P-2O content was obtained with the solvent-free system. Furthermore, the solvent-free system showed a higher reaction rate for 1P-2O synthesis than did the hexane system, with no effect on chiral specificity of the lipase for the TAG molecules. These results suggested that among three types of commercial lipase, Lipozyme RM-IM is the most useful for the preparation of chiral TAGs by acidolysis reaction.
[Mh] Termos MeSH primário: Lipase/química
Triglicerídeos/síntese química
[Mh] Termos MeSH secundário: Ácido Palmítico/química
Solventes
Estereoisomerismo
Fatores de Tempo
Triglicerídeos/química
Trioleína/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Solvents); 0 (Triglycerides); 122-32-7 (Triolein); 2V16EO95H1 (Palmitic Acid); EC 3.1.1.3 (Lipase)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess17149


  3 / 46310 MEDLINE  
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[PMID]:29367479
[Au] Autor:Pornputtapitak W; Pantakitcharoenkul J; Panpakdee R; Teeranachaideekul V; Sinchaipanid N
[Ad] Endereço:Department of Chemical Engineering, Faculty of Engineering, Mahidol University.
[Ti] Título:Development of γ-Oryzanol Rich Extract from Leum Pua Glutinous Rice Bran Loaded Nanostructured Lipid Carriers for Topical Delivery.
[So] Source:J Oleo Sci;67(2):125-133, 2018 Feb 01.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Leum Pua is native Thai glutinous rice that contains antioxidants higher than white rice and other colored rice. One of the major antioxidants in rice brans is γ-oryzanol (GO). In this study, Leum Pua glutinous rice bran was extracted by different solvents. Oleic acid (~40 g/100 g extract), linoleic acid (~30 g/100 g extract), and palmitic acid (~20 g/100 g extract) were found to be major lipid components in the extracts. Methanol extract showed less variety of lipid components compared to the others. However, hexane extract showed the highest percent of γ-oryzanol compared to other solvents. Therefore, the hexane extract was selected to prepare nanostructured lipid carriers (NLC). The prepared NLC had small particles in the size range of 142.9 ± 0.4 nm for extract-loaded NLC and 137.1 ± 0.5 nm for GO-loaded NLC with narrow size distribution (PI < 0.1) in both formulations. The release profile of extract-loaded NLC formulation was slightly higher than GO-loaded NLC formulation. However, they did not follow the Higuchi model because of small amounts of γ-oryzanol loaded in NLC particles.
[Mh] Termos MeSH primário: Antioxidantes/isolamento & purificação
Portadores de Fármacos
Nanoestruturas
Oryza/química
Fenilpropionatos/isolamento & purificação
Extratos Vegetais/análise
Extratos Vegetais/isolamento & purificação
[Mh] Termos MeSH secundário: Hexanos
Ácido Linoleico/análise
Ácido Oleico/análise
Ácido Palmítico/análise
Tamanho da Partícula
Fenilpropionatos/análise
Solventes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Drug Carriers); 0 (Hexanes); 0 (Phenylpropionates); 0 (Plant Extracts); 0 (Solvents); 2UMI9U37CP (Oleic Acid); 2V16EO95H1 (Palmitic Acid); 9KJL21T0QJ (Linoleic Acid); SST9XCL51M (gamma-oryzanol)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess17113


  4 / 46310 MEDLINE  
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[PMID]:29273907
[Au] Autor:Ghiasvand AR; Nouriasl K; Yazdankhah F
[Ad] Endereço:Department of Chemistry, Lorestan University, Khoramabad, Lorestan Province, 6713817133, Iran. a_ghiasvand@yahoo.com.
[Ti] Título:Comparison of the atmospheric- and reduced-pressure HS-SPME strategies for analysis of residual solvents in commercial antibiotics using a steel fiber coated with a multiwalled carbon nanotube/polyaniline nanocomposite.
[So] Source:Anal Bioanal Chem;410(2):361-371, 2018 Jan.
[Is] ISSN:1618-2650
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A low-cost, sensitive and reliable reduced-pressure headspace solid-phase microextraction (HS-SPME) setup was developed and evaluated for direct extraction of residual solvents in commercial antibiotics, followed by determination by gas chromatography with flame ionization detection (GC-FID). A stainless steel narrow wire was made porous and adhesive by platinization by a modified electrophoretic deposition method and coated with a polyaniline/multiwalled carbon nanotube nanocomposite. All experimental variables affecting the extraction efficiency were investigated for both atmospheric-pressure and reduced-pressure conditions. Comparison of the optimal experimental conditions and the results demonstrated that the reduced-pressure strategy leads to a remarkable increase in the extraction efficiency and reduction of the extraction time and temperature (10 min, 25 °Ï¹ vs 20 min, 40 °Ï¹). Additionally, the reduced-pressure strategy showed better analytical performances compared with those obtained by the conventional HS-SPME-GC-FID method. Limit of detections, linear dynamic ranges, and relative standard deviations of the reduced-pressure HS-SPME procedure for benzene, toluene, ethylbenzene, and xylene (BTEX) in injectable solid drugs were obtained over the ranges of 20-100 pg g , 0.02-40 µg g , and 2.8-10.2%, respectively. The procedure developed was successful for the analysis of BTEX in commercial containers of penicillin, ampicillin, ceftriaxone, and cefazolin. Graphical abstract Schematic representation of the developed RP-HS-SPME setup.
[Mh] Termos MeSH primário: Compostos de Anilina/química
Antibacterianos/análise
Nanocompostos/química
Nanotubos de Carbono/química
Microextração em Fase Sólida/instrumentação
Solventes/análise
Xilenos/análise
[Mh] Termos MeSH secundário: Pressão Atmosférica
Contaminação de Medicamentos
Desenho de Equipamento
Nanocompostos/ultraestrutura
Nanotubos de Carbono/ultraestrutura
Solventes/isolamento & purificação
Aço/química
Xilenos/isolamento & purificação
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aniline Compounds); 0 (Anti-Bacterial Agents); 0 (Nanotubes, Carbon); 0 (Solvents); 0 (Xylenes); 0 (polyaniline); 12597-69-2 (Steel)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171224
[St] Status:MEDLINE
[do] DOI:10.1007/s00216-017-0726-7


  5 / 46310 MEDLINE  
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[PMID]:29264676
[Au] Autor:Faraji H; Helalizadeh M; Kordi MR
[Ad] Endereço:Department of Chemistry, Varamin-Pishva Branch, Islamic Azad University, Varamin, 338177489, Iran. hakimfaraji@yahoo.com.
[Ti] Título:Overcoming the challenges of conventional dispersive liquid-liquid microextraction: analysis of THMs in chlorinated swimming pools.
[So] Source:Anal Bioanal Chem;410(2):605-614, 2018 Jan.
[Is] ISSN:1618-2650
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A rapid, simple, and sensitive approach to the analysis of trihalomethanes (THMs) in swimming pool water samples has been developed. The main goal of this study was to overcome or to improve the shortcomings of conventional dispersive liquid-liquid microextraction (DLLME) and to maximize the realization of green analytical chemistry principles. The method involves a simple vortex-assisted microextraction step, in the absence of the dispersive solvent, followed by salting-out effect for the elimination of the centrifugation step. A bell-shaped device and a solidifiable solvent were used to simplify the extraction solvent collection after phase separation. Optimization of the independent variables was performed by using chemometric methods in three steps. The method was statistically validated based on authentic guidance documents. The completion time for extraction was less than 8 min, and the limits of detection were in the range between 4 and 72 ng L . Using this method, good linearity and precision were achieved. The results of THMs determination in different real samples showed that in some cases the concentration of total THMs was more than threshold values of THMs determined by accredited healthcare organizations. This method indicated satisfactory analytical figures of merit. Graphical Abstract A novel green microextraction technique for overcoming the challenges of conventional DLLME. The proposed procedure complies with the principles of green/sustainable analytical chemistry, comprising decreasing the sample size, making easy automation of the process, reducing organic waste, diminishing energy consumption, replacing toxic reagents with safer reagents, and enhancing operator safety.
[Mh] Termos MeSH primário: Microextração em Fase Líquida/métodos
Piscinas
Trialometanos/análise
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Halogenação
Limite de Detecção
Solventes
Trialometanos/isolamento & purificação
Água/análise
Poluentes Químicos da Água/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Solvents); 0 (Trihalomethanes); 0 (Water Pollutants, Chemical); 059QF0KO0R (Water)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.1007/s00216-017-0762-3


  6 / 46310 MEDLINE  
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[PMID]:29318311
[Au] Autor:Santaladchaiyakit Y; Bunchamnan J; Tongsa D; Srijaranai S
[Ti] Título:Methyl Salicylate-Based Vortex-Assisted Surfactant-Enhanced Emulsification Microextraction and HPLC for Determination of Fungicides in Honey Samples.
[So] Source:Acta Chim Slov;64(4):849-857, 2017 Dec.
[Is] ISSN:1318-0207
[Cp] País de publicação:Slovenia
[La] Idioma:eng
[Ab] Resumo:Methyl salicylate based vortex-assisted surfactant-enhanced emulsification microextraction (MeSA-VASEME) has been developed and applied for rapid preconcentration of fungicides (i.e., carbendazim, thiabendazole, and fluberidazole) in honey samples followed by high performance liquid chromatographic analysis. MeSA was used as an extraction solvent, while surfactant was used to enhance the extraction performance under the dispersion by vortex agitation. The optimum MeSA-VASEME conditions were 100 µL MeSA, 2.0 mmol L‒1 sodium dodecyl sulfate, and vortex agitation at 1200 rpm for 90 s. Preconcentration factors were obtained in the range of 32-40. The limit of detection in the studied honey samples was 0.5 µg L‒1. The recovery of the spiked target fungicides at 20, 50, and 100 µg L‒1 were 81.5-116.8 % with the relative standard deviation below 11%. The proposed method is simple, sensitive, less organic solvent consuming, inexpensive, and a rapid procedure for the residue analysis of fungicides in honey samples.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Fungicidas Industriais/análise
Mel/análise
Microextração em Fase Líquida/métodos
[Mh] Termos MeSH secundário: Emulsões
Concentração de Íons de Hidrogênio
Salicilatos/química
Solventes/química
Tensoativos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Emulsions); 0 (Fungicides, Industrial); 0 (Salicylates); 0 (Solvents); 0 (Surface-Active Agents); LAV5U5022Y (methyl salicylate)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE


  7 / 46310 MEDLINE  
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[PMID]:29430907
[Au] Autor:Momot TV; Kushnerova NF; Rakhmanin YA
[Ti] Título:[Modification of the pattern of fatty acids of erythrocytes' membranes due to the acetone intoxication].
[So] Source:Gig Sanit;95(8):782-5, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Results of the study of the impact of acetone intoxication on the fatty acids pattern of the general lipids of erythrocytes' membranes in rats are presented. The inhalation exposure of acetone was carried out in the inoculation chamber with the volume of 100 liters. The chamber was designed for the type of B.A. Kurlyandsky with self-contained system of purification and air regeneration and specified parameters of temperature (20-22С) and air humidity. The flow rate of the air and aerosolized acetone passed through the chamber accounted of 10 liters/min. Concentration of acetone in the chamber was sustained at the level of 206 ± 3,9 mg/m that corresponds to maximum permissible concentration for acetone vapor in the air of a working area. The time of exposure was 6 hours per day for 3 weeks in a monotonous mode, excluding weekend, and was based upon specific parameters of environment simulation in industry. The acetone impact was shown to be accompanied by the gain in the quantity of all kinds of saturated fatty acids and the fall of unsaturated fatty acids in general lipids of erythrocytes ' membranes in rats and in the structure ofphospholipid fractions. In the content of phosphatydilcholine and phosphatydilethanolamine, as a basic structural phospholipids of biological membranes, there was noted the increase in palmitic and stearic acids. In the range offatty acids of the n-6 family the amount of linoleic and arachidonic acids decreased. In the array of fatty acids of the n-3 family the content of linolenic, eicosapentaenoic and docosahexaenoic acids (n-3 family) declined. Redistribution of fatty acids in the erythrocytes membrane towards to such alteration in quantity as the increasing of saturation and decreasing of the unsaturated fatty acids supposes the change of its physical and chemical properties, permeability, lability and complexity of passing erythrocyte via microcircular channels.
[Mh] Termos MeSH primário: Acetona/toxicidade
Membrana Eritrocítica
Ácidos Graxos/metabolismo
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Membrana Eritrocítica/efeitos dos fármacos
Membrana Eritrocítica/metabolismo
Exposição por Inalação/efeitos adversos
Exposição por Inalação/prevenção & controle
Lipídeos de Membrana/metabolismo
Ratos
Solventes/toxicidade
Testes de Toxicidade/métodos
Xenobióticos/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Membrane Lipids); 0 (Solvents); 0 (Xenobiotics); 1364PS73AF (Acetone)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE


  8 / 46310 MEDLINE  
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[PMID]:29430905
[Au] Autor:Sbitnev AV; Vodianova MA; Kriatov IA; Donerian LG; Evseeva IS; Ushakova OV; Ushakov DI; Matveeva IS; Rodionova OM
[Ti] Título:[Methodological aspects of the assessment of phytotoxicic properties of ice-melter reagents].
[So] Source:Gig Sanit;95(8):773-8, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:One of the main criteria which determine the possibility of the use of a particular type of ice-melter reagents (IMR) is the degree of their safety for the environment and human health, which is reflected in the establishment of safe doses and concentrations. In this regard, the current area of research is to improve the ecological and epidemiological principles of risk assessment of modern types of anti-icing agents. Currently available data concerning monitoring soil studies and the snow held in various cities of Russia, show that there is a process of accumulation of the main components of IMR - sodium and chlorine ions in the areas related to the roadway. The article is designated a problem of existing methodological approaches to the assessment of the phytotoxic impact in the investigation of anti-icing agents in the laboratory. There was executed the comparative characteristics of the results of the preliminary pilot studies on the phytotoxic properties of IMR under using different substrates for germination of seeds - soil and filter paper. The data obtained are characterized by differences in the degree of phytotoxic action of the same species depending upon ice-melter reagents methodical setting circuit laboratory experiment. As a result, there was shown the imperfection of the existing method of rapid analysis in relation to ice-melter materials (IMM).
[Mh] Termos MeSH primário: Monitoramento Ambiental/métodos
Congelamento
Gelo
Plantas/efeitos dos fármacos
Neve
Cloreto de Sódio
Poluentes do Solo
[Mh] Termos MeSH secundário: Poluição Ambiental/efeitos adversos
Poluição Ambiental/análise
Poluição Ambiental/prevenção & controle
Seres Humanos
Federação Russa
Cloreto de Sódio/química
Cloreto de Sódio/toxicidade
Poluentes do Solo/química
Poluentes do Solo/toxicidade
Solventes/química
Fenômenos Toxicológicos
Transportes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ice); 0 (Soil Pollutants); 0 (Solvents); 451W47IQ8X (Sodium Chloride)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE


  9 / 46310 MEDLINE  
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[PMID]:29340521
[Au] Autor:Oliveira AR; Campos Neto AA; de Andrade MJO; de Medeiros PCB; Dos Santos NA
[Ad] Endereço:Departamento de Psicologia, Universidade Federal de Campina Grande, Campina Grande, PB, Brasil.
[Ti] Título:Organic solvent exposure and contrast sensitivity: comparing men and women.
[So] Source:Braz J Med Biol Res;51(3):e6568, 2018 Jan 11.
[Is] ISSN:1414-431X
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The goal of this study was to compare the visual contrast sensitivity (CS) of men and women exposed and not exposed to organic solvents. Forty-six volunteers of both genders aged between 18 and 41 years (mean±SD=27.72±6.28) participated. Gas station attendants were exposed to gas containing 46.30 ppm of solvents at a temperature of 304±274.39 K, humidity of 62.25±7.59% and ventilation of 0.69±0.46 m/s (a passive gas chromatography-based sampling method was used considering the microclimate variables). Visual CS was measured via the psychophysical method of two-alternative forced choice using vertical sinusoidal gratings with spatial frequencies of 0.2, 0.5, 1.0, 2.0, 5.0, 10.0, and 16.0 cpd (cycles per degree) and an average luminance of 34.4 cd/m2. The results showed that visual CS was significantly lower (P<0.05) in the following groups: i) exposed men compared to unexposed men at frequencies of 0.2, 0.5, 1.0, and 2.0 cpd; ii) exposed women compared to unexposed women at a frequency of 5.0 cpd; and iii) exposed women compared to exposed men at a frequency of 0.5 cpd, even at exposures below the tolerance limit (300 ppm). These results suggest that the visual CS of exposed men was impaired over a wider range of spatial frequencies than that of exposed women. This difference may have been due to the higher body fat content of women compared to that of men, suggesting that body fat in women can serve as a protective factor against neurotoxic effects.
[Mh] Termos MeSH primário: Sensibilidades de Contraste/efeitos dos fármacos
Exposição Ocupacional/efeitos adversos
Solventes/efeitos adversos
Percepção Visual/fisiologia
[Mh] Termos MeSH secundário: Tecido Adiposo/anatomia & histologia
Adolescente
Adulto
Brasil/epidemiologia
Escolaridade
Feminino
Seres Humanos
Masculino
Microclima
Exposição Ocupacional/estatística & dados numéricos
Limiar Sensorial/fisiologia
Fatores Sexuais
Aprendizagem Espacial/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Solvents)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE


  10 / 46310 MEDLINE  
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[PMID]:27774620
[Au] Autor:Vendramin C; McGuckin S; Alwan F; Westwood JP; Thomas M; Scully M
[Ad] Endereço:Department of Haematology, University College London Hospital.
[Ti] Título:A single-center prospective study on the safety of plasma exchange procedures using a double-viral-inactivated and prion-reduced solvent/detergent fresh-frozen plasma as the replacement fluid in the treatment of thrombotic microangiopathy.
[So] Source:Transfusion;57(1):131-136, 2017 01.
[Is] ISSN:1537-2995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Patients presenting with acute episodes of thrombotic microangiopathies (TMAs) require urgent access to plasma exchange (PEX). OctaplasLG, a solvent/detergent fresh-frozen plasma product that has undergone viral inactivation and prion reduction step, has been used in our institution since 2013, replacing Octaplas. STUDY DESIGN AND METHODS: We prospectively reviewed 981 PEX procedures where OctaplasLG was the replacement fluid in 90 patients admitted acutely with a TMA presentation within our institution from January 1, 2013, to December 31, 2015. We recorded citrate toxicities, plasma reactions, viral transfer, complications related to central venous catheter, and venous thrombotic events (VTEs). RESULTS: Citrate toxicities were 5.4%, plasma reactions were 2%, and all were classified as Grade 1 or 2. VTE had an incidence of 12.2%, although 50% of the episodes occurred in early remission when patients were not receiving PEX. No line insertions complications were recorded. Line-associated infections were 2.2%. Hepatitis B and C serology and human immunodeficiency virus (HIV) were checked on admission. There were four patients who may have had passive transient transfer of hepatitis B antibodies from pooled plasma. No hepatitis C or HIV viral transfer was documented after treatment and no seroconversion was detected after treatment. CONCLUSION: Our data have demonstrated that the incidence of complications during PEX is low and using OctaplasLG is comparable to the low incidence of reactions. No cases of anaphylaxis, transfusion-related acute lung injury, or fatal plasma reactions were seen. There was no evidence of viral transmission or seroconversion after treatment.
[Mh] Termos MeSH primário: Desinfecção/métodos
Troca Plasmática/métodos
Plasma
Príons
Microangiopatias Trombóticas/terapia
Inativação de Vírus
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Detergentes/química
Feminino
HIV
Infecções por HIV/prevenção & controle
Hepacivirus
Hepatite B/prevenção & controle
Vírus da Hepatite B
Hepatite C/prevenção & controle
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Solventes/química
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Detergents); 0 (Prions); 0 (Solvents)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1111/trf.13877



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