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  1 / 1938 MEDLINE  
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[PMID]:29305456
[Au] Autor:Sprague S; Petrisor B; Jeray K; McKay P; Heels-Ansdell D; Schemitsch E; Liew S; Guyatt G; Walter SD; Bhandari M; FLOW Investigators
[Ad] Endereço:McMaster University, 293 Wellington Street North, Suite 110, Hamilton, Ontario L8L 8E7, Canada.
[Ti] Título:Wound irrigation does not affect health-related quality of life after open fractures: results of a randomized controlled trial.
[So] Source:Bone Joint J;100-B(1):88-94, 2018 01.
[Is] ISSN:2049-4408
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: The Fluid Lavage in Open Fracture Wounds (FLOW) trial was a multicentre, blinded, randomized controlled trial that used a 2 × 3 factorial design to evaluate the effect of irrigation solution (soap normal saline) and irrigation pressure (very low low high) on health-related quality of life (HRQL) in patients with open fractures. In this study, we used this dataset to ascertain whether these factors affect whether HRQL returns to pre-injury levels at 12-months post-injury. PATIENTS AND METHODS: Participants completed the Short Form-12 (SF-12) and the EuroQol-5 Dimensions (EQ-5D) at baseline (pre-injury recall), at two and six weeks, and at three, six, nine and 12-months post-fracture. We calculated the Physical Component Score (PCS) and the Mental Component Score (MCS) of the SF-12 and the EQ-5D utility score, conducted an analysis using a multi-level generalized linear model, and compared differences between the baseline and 12-month scores. RESULTS: We found no clinically important differences between irrigating solutions or pressures for the SF-12 PCS, SF-12 MCS and EQ-5D. Irrespective of treatment, participants had not returned to their pre-injury function at 12-months for any of the three outcomes (p < 0.001). CONCLUSION: Neither the composition of the irrigation solution nor irrigation pressure applied had an effect on HRQL. Irrespective of treatment, patients had not returned to their pre-injury HRQL at 12 months post-fracture. Cite this article: 2018;100-B:88-94.
[Mh] Termos MeSH primário: Fraturas Expostas/terapia
Qualidade de Vida
Irrigação Terapêutica/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seguimentos
Fixação Interna de Fraturas/métodos
Fraturas Expostas/reabilitação
Seres Humanos
Masculino
Meia-Idade
Pressão
Psicometria
Sabões/administração & dosagem
Cloreto de Sódio/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Soaps); 451W47IQ8X (Sodium Chloride)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180107
[St] Status:MEDLINE
[do] DOI:10.1302/0301-620X.100B1.BJJ-2017-0955.R1


  2 / 1938 MEDLINE  
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[PMID]:27774794
[Au] Autor:Seay JS; Mandigo M; Kish J; Menard J; Marsh S; Kobetz E
[Ad] Endereço:a Miller School of Medicine , University of Miami , Miami , FL , USA.
[Ti] Título:Intravaginal practices are associated with greater odds of high-risk HPV infection in Haitian women.
[So] Source:Ethn Health;22(3):257-265, 2017 Jun.
[Is] ISSN:1465-3419
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Haitian women have the highest incidence of cervical cancer within the Western hemisphere. Intravaginal hygiene practices have been linked with human papilloma virus (HPV) infection and cervical dysplasia. These practices, known as 'twalet deba' in Haitian Creole, are common among Haitian women and are performed with various natural and synthetic agents. As part of a community-based participatory research initiative aimed at reducing cervical cancer disparities in rural Haiti, we explored the use of intravaginal agents and their associations with high-risk HPV infection. DESIGN: Community Health Workers recruited 416 women for cervical self-sampling from two neighborhoods within Thomonde, Haiti. Participants were interviewed regarding intravaginal hygiene practices and completed a cervical self-sampling procedure. Cervical samples were analyzed for the presence of high-risk HPV infection. Associations between each intravaginal agent and high-risk HPV infection were examined via univariate logistic regression analyses, as well as via multivariate analyses controlling for sociodemographic factors and concurrent agent use. RESULTS: Nearly all women (97.1%) performed twalet deba, using a variety of herbal and commercially produced intravaginal agents. Approximately 11% of the participants tested positive for high-risk HPV. Pigeon pea and lime juice were the only agents found to be associated with high-risk HPV in the univariate analyses, with women who used these agents being approximately twice as likely to have high-risk HPV as those who did not. Only pigeon pea remained significantly associated with high-risk HPV after controlling for sociodemographic factors and concurrent agent use. CONCLUSION: Two agents, pigeon pea and lime juice, may contribute to risk for HPV infection in this population. Results suggest that in addition to cervical cancer screening interventions, future preventive initiatives should focus on minimizing risk by advocating for the use of less-toxic twalet deba alternatives.
[Mh] Termos MeSH primário: Conhecimentos, Atitudes e Prática em Saúde/etnologia
Higiene
Infecções por Papillomavirus/etnologia
Ducha Vaginal/efeitos adversos
[Mh] Termos MeSH secundário: Administração Intravaginal
Adulto
Compostos de Alúmen/administração & dosagem
Cajanus
Citrus aurantiifolia
Pesquisa Participativa Baseada na Comunidade
Feminino
Sucos de Frutas e Vegetais
Haiti/epidemiologia
Seres Humanos
Infecções por Papillomavirus/epidemiologia
Infecções por Papillomavirus/virologia
Preparações de Plantas/administração & dosagem
Permanganato de Potássio/administração & dosagem
Fatores de Risco
Sabões/administração & dosagem
Ducha Vaginal/métodos
Saúde da Mulher/etnologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alum Compounds); 0 (Plant Preparations); 0 (Soaps); 00OT1QX5U4 (Potassium Permanganate); 34S289N54E (aluminum sulfate)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1080/13557858.2016.1246423


  3 / 1938 MEDLINE  
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[PMID]:29182464
[Au] Autor:Weatherly LM; Gosse JA
[Ad] Endereço:a Graduate School of Biomedical Science and Engineering , University of Maine , Orono , ME , USA.
[Ti] Título:Triclosan exposure, transformation, and human health effects.
[So] Source:J Toxicol Environ Health B Crit Rev;20(8):447-469, 2017.
[Is] ISSN:1521-6950
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Triclosan (TCS) is an antimicrobial used so ubiquitously that 75% of the US population is likely exposed to this compound via consumer goods and personal care products. In September 2016, TCS was banned from soap products following the risk assessment by the US Food and Drug Administration (FDA). However, TCS still remains, at high concentrations, in other personal care products such as toothpaste, mouthwash, hand sanitizer, and surgical soaps. TCS is readily absorbed into human skin and oral mucosa and found in various human tissues and fluids. The aim of this review was to describe TCS exposure routes and levels as well as metabolism and transformation processes. The burgeoning literature on human health effects associated with TCS exposure, such as reproductive problems, was also summarized.
[Mh] Termos MeSH primário: Anti-Infecciosos Locais/toxicidade
Poluentes Ambientais/toxicidade
Triclosan/toxicidade
[Mh] Termos MeSH secundário: Animais
Anti-Infecciosos Locais/química
Anti-Infecciosos Locais/metabolismo
Poluentes Ambientais/química
Poluentes Ambientais/metabolismo
Higienizadores de Mão
Seres Humanos
Antissépticos Bucais
Sabões
Cremes Dentais
Triclosan/química
Triclosan/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Anti-Infective Agents, Local); 0 (Environmental Pollutants); 0 (Hand Sanitizers); 0 (Mouthwashes); 0 (Soaps); 0 (Toothpastes); 4NM5039Y5X (Triclosan)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1080/10937404.2017.1399306


  4 / 1938 MEDLINE  
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[PMID]:28455208
[Au] Autor:Félix S; Araújo J; Pires AM; Sousa AC
[Ad] Endereço:Universidade Atlântica - Centro de Estudos, Sociedade, Organizações e Bem-Estar (CESOB), Antiga Fábrica da Pólvora de Barcarena 2730-036 Barcarena, Oeiras, Portugal. Electronic address: sfelix@uatlantica.pt.
[Ti] Título:Soap production: A green prospective.
[So] Source:Waste Manag;66:190-195, 2017 Aug.
[Is] ISSN:1879-2456
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A green prospective based on the reuse of waste materials such as almond shells, orange peel and used cooking oil to manufacture soap is presented. In Portugal, thousands of tons of waste are generated from used cooking oil and production of nut shells' residues is growing every year. In addition, the high consumption of citrus fruits, oranges in particular, generates large amounts of citrus peel. Therefore, it is necessary to diversify reuse mechanisms of these wastes, in order to make them back into raw materials. Complying with this trend, this work was carried out by processing and grinding almond shells, treating used oil, processing orange peels and extracting limonene, formulating and producing soap, and performing an acceptance study of the final product. Results validated a high potential of the idea in the field of environmental education, so it can be replicated in practical classes. It can also be useful for waste management, and it can support the development of community projects on an ecological approach.
[Mh] Termos MeSH primário: Reciclagem
Sabões
[Mh] Termos MeSH secundário: Citrus
Citrus sinensis
Portugal
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soaps)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171213
[Lr] Data última revisão:
171213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


  5 / 1938 MEDLINE  
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[PMID]:28876132
[Au] Autor:Pérez-Garza J; García S; Heredia N
[Ad] Endereço:Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, Apdo. Postal 124-F, San Nicolás, Nuevo León 66451, México.
[Ti] Título:Removal of Escherichia coli and Enterococcus faecalis after Hand Washing with Antimicrobial and Nonantimicrobial Soap and Persistence of These Bacteria in Rinsates.
[So] Source:J Food Prot;80(10):1670-1675, 2017 Oct.
[Is] ISSN:1944-9097
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Food handlers are important sources of contamination in the agricultural environment. This study was conducted (i) to evaluate the activity of antimicrobial soaps against Escherichia coli and Enterococcus faecalis using a hand washing model with soiled hands and (ii) to determine the survival and persistence of these bacteria in rinsates. Sterilized agricultural soil from tomato and pepper farms was inoculated with E. coli or E. faecalis at 10 or 10 CFU/g. Decontaminated hands were placed in contact with contaminated soil for 2 min and were then washed with soaps with or without antimicrobial compounds (citric extracts, chloroxylenol, triclosan, or chlorhexidine gluconate). As the control, hands were washed with sterile distilled water. The levels of bacteria remaining on the hands and recovered from the rinsates were determined using a membrane filtration method and selective media. Antimicrobial soaps removed levels of E. coli similar to those removed by distilled water and nonantimicrobial soap on hands contaminated with E. coli at 10 CFU/g. However, when hands were contaminated with E. coli at 10 CFU/g, more E. coli was removed with the chlorhexidine gluconate soap. When hands were contaminated with E. faecalis at 10 CFU/g, bacteria were removed more effectively with soaps containing chloroxylenol or chlorhexidine gluconate. When hands were contaminated with E. faecalis at 10 CFU/g, all of the antimicrobial soaps were more effective for removing the bacteria than were distilled water and nonantimicrobial soap. E. coli grew in all of the hand washing rinsates except that containing triclosan, whereas E. faecalis from the 10 CFU/g treatments grew in rinsates containing chlorhexidine gluconate and in the distilled water rinsates. Washing with antimicrobial soap was more effective for reducing bacteria on soiled hands than was washing with water or nonantimicrobial soap. However, persistence or growth of bacteria in these rinsates poses health risks.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Enterococcus faecalis/isolamento & purificação
Escherichia coli/isolamento & purificação
Desinfecção das Mãos/métodos
[Mh] Termos MeSH secundário: Bactérias
Contagem de Colônia Microbiana
Mãos
Seres Humanos
Sabões
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Soaps)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE
[do] DOI:10.4315/0362-028X.JFP-17-088


  6 / 1938 MEDLINE  
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[PMID]:28722572
[Au] Autor:Kumar S; Loughnan L; Luyendijk R; Hernandez O; Weinger M; Arnold F; Ram PK
[Ad] Endereço:University at Buffalo, Buffalo, New York.
[Ti] Título:Handwashing in 51 Countries: Analysis of Proxy Measures of Handwashing Behavior in Multiple Indicator Cluster Surveys and Demographic and Health Surveys, 2010-2013.
[So] Source:Am J Trop Med Hyg;97(2):447-459, 2017 Aug.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In 2009, a common set of questions addressing handwashing behavior was introduced into nationally representative Demographic and Health Surveys (DHS) and Multiple Indicator Cluster Surveys (MICS), providing large amounts of comparable data from numerous countries worldwide. The objective of this analysis is to describe global handwashing patterns using two proxy indicators for handwashing behavior from 51 DHS and MICS surveys conducted in 2010-2013: availability of soap anywhere in the dwelling and access to a handwashing place with soap and water. Data were also examined across geographic regions, wealth quintiles, and rural versus urban settings. We found large disparities for both indicators across regions, and even among countries within the same World Health Organization region. Within countries, households in lower wealth quintiles and in rural areas were less likely to have soap anywhere in the dwelling and at designated handwashing locations than households in higher wealth quintiles and urban areas. In addition, disparities existed among various geographic regions within countries. This analysis demonstrates the need to promote access to handwashing materials and placement at handwashing locations in the dwelling, particularly in poorer, rural areas where children are more vulnerable to handwashing-preventable syndromes such as pneumonia and diarrhea.
[Mh] Termos MeSH primário: Atitude Frente à Saúde
Desinfecção das Mãos
Comportamentos Relacionados com a Saúde
Inquéritos Epidemiológicos
Sabões
[Mh] Termos MeSH secundário: Demografia
Geografia
Conhecimentos, Atitudes e Prática em Saúde
Seres Humanos
População Rural/estatística & dados numéricos
Fatores Socioeconômicos
Inquéritos e Questionários
População Urbana/estatística & dados numéricos
Abastecimento de Água
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Soaps)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170720
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.16-0445


  7 / 1938 MEDLINE  
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[PMID]:28719285
[Au] Autor:Gautam OP; Schmidt WP; Cairncross S; Cavill S; Curtis V
[Ad] Endereço:London School of Hygiene and Tropical Medicine, London, United Kingdom.
[Ti] Título:Trial of a Novel Intervention to Improve Multiple Food Hygiene Behaviors in Nepal.
[So] Source:Am J Trop Med Hyg;96(6):1415-1426, 2017 Jun.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AbstractIn this study, we report on the results of a trial of an intervention to improve five food hygiene behaviors among mothers of young children in rural Nepal. This novel intervention targeted five behaviors; cleanliness of serving utensils, handwashing with soap before feeding, proper storage of cooked food, and thorough reheating and water treatment. Based on formative research and a creative process using the Behavior-Centered Design approach, an innovative intervention package was designed and delivered over a period of 3 months. The intervention activities included local rallies, games, rewards, storytelling, drama, competitions linking with emotional drivers of behavior, and "kitchen makeovers" to disrupt behavior settings. The effect of the package on behavior was evaluated via a cluster-randomized before-after study in four villages with four villages serving as controls. The primary outcome was the difference in the mean cluster level proportions of mothers directly observed practicing all five food hygiene behaviors. The five targeted food hygiene behaviors were rare at baseline (composite performance of all five behaviors in intervention 1% [standard deviation (SD) = 2%] and in control groups 2% [SD = 2%]). Six weeks after the intervention, the target behaviors were more common in the intervention than in the control group (43% [SD = 14%] versus 2% [SD = 2%], = 0.02) during follow-up. The intervention appeared to be equally effective in improving all five behaviors in all intervention clusters. This study shows that a theory-driven, systematic approach employing emotional motivators and modifying behavior settings was capable of substantially improving multiple food hygiene behaviors in Nepal.
[Mh] Termos MeSH primário: Contaminação de Alimentos/prevenção & controle
Manipulação de Alimentos/métodos
Comportamentos Relacionados com a Saúde
Educação em Saúde
Higiene
[Mh] Termos MeSH secundário: Adolescente
Adulto
Pré-Escolar
Análise por Conglomerados
Feminino
Desinfecção das Mãos
Seres Humanos
Lactente
Meia-Idade
Nepal
Sabões
Fatores Socioeconômicos
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Soaps)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.16-0526


  8 / 1938 MEDLINE  
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[PMID]:28719281
[Au] Autor:Burrowes V; Perin J; Monira S; Sack DA; Rashid MU; Mahamud T; Rahman Z; Mustafiz M; Bhuyian SI; Begum F; Zohura F; Biswas S; Parvin T; Hasan T; Zhang X; Sack BR; Saif-Ur-Rahman KM; Alam M; George CM
[Ad] Endereço:Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
[Ti] Título:Risk Factors for Household Transmission of in Dhaka, Bangladesh (CHoBI7 Trial).
[So] Source:Am J Trop Med Hyg;96(6):1382-1387, 2017 Jun.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AbstractHousehold contacts of cholera patients are at a 100 times higher risk of a infection than the general population. To examine risk factors for infections and investigate intervention strategies among this population, we followed household contacts of cholera patients for the 1-week high-risk period after the index patient obtained care. This study was nested within a randomized controlled trial of the Cholera-Hospital-Based-Intervention-for-7-days (CHoBI7), a handwashing with soap and water treatment intervention in Dhaka, Bangladesh. Rectal swab results were available from 320 household contacts of cholera patients at five time points over a 1-week period. Fecal and water samples were analyzed for by bacterial culture. All analyses were stratified by study arm. Within the intervention arm, stored household drinking water with a median free chlorine concentration below 0.5 mg/L was associated with a three times higher odds of a cholera infection (odds ratio [OR]: 3.0; 95% confidence interval [CI]: 1.32, 6.63). In the control arm, having in stored water was associated with a significantly higher odds of a symptomatic cholera infection (OR: 8.66; 95% CI: 2.11, 35.48). No association was found between observed handwashing with soap at food and stool-related events and infections. Stored household drinking water with detectable and chlorine concentrations below the World Health Organization guideline were found to be important risk factors for cholera infection among household contacts of cholera patients. These findings emphasize the need for water treatment interventions targeting this high risk population.
[Mh] Termos MeSH primário: Cólera/epidemiologia
Cólera/transmissão
Vibrio cholerae
[Mh] Termos MeSH secundário: Adolescente
Bangladesh/epidemiologia
Criança
Pré-Escolar
Cloro/análise
Água Potável/microbiologia
Fezes/microbiologia
Feminino
Contaminação de Alimentos/análise
Microbiologia de Alimentos
Desinfecção das Mãos
Hospitais
Seres Humanos
Lactente
Masculino
Fatores de Risco
Sabões
Purificação da Água/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Drinking Water); 0 (Soaps); 4R7X1O2820 (Chlorine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170916
[Lr] Data última revisão:
170916
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.16-0871


  9 / 1938 MEDLINE  
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[PMID]:28678121
[Au] Autor:Madden K; Scott T; McKay P; Petrisor BA; Jeray KJ; Tanner SL; Bhandari M; Sprague S
[Ad] Endereço:1Department of Clinical Epidemiology and Biostatistics (K.M., T.S., P.McK., M.B., and S.S.) and Division of Orthopaedic Surgery, Department of Surgery (B.A.P., M.B., and S.S.), McMaster University, Hamilton, Ontario, Canada 2Department of Orthopaedic Surgery, Greenville Health System, Greenville, South Carolina.
[Ti] Título:Predicting and Preventing Loss to Follow-up of Adult Trauma Patients in Randomized Controlled Trials: An Example from the FLOW Trial.
[So] Source:J Bone Joint Surg Am;99(13):1086-1092, 2017 Jul 05.
[Is] ISSN:1535-1386
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: High loss-to-follow-up rates are a risk in even the most rigorously designed randomized controlled trials (RCTs). Consequently, predicting and preventing loss to follow-up are important methodological considerations. We hypothesized that certain baseline characteristics are associated with a greater likelihood of patients being lost to follow-up. Our primary objective was to determine which baseline characteristics are associated with loss to follow-up within 12 months after an open fracture in adult patients participating in the Fluid Lavage of Open Wounds (FLOW) trial. We also present strategies to reduce loss to follow-up in trauma trials. METHODS: Data for this study were derived from the FLOW trial, a funded trial in which payments to clinical sites were tied to participant retention. We conducted a binary logistic regression analysis with loss to follow-up as the dependent variable to determine participant characteristics associated with a higher risk of loss to follow-up. RESULTS: Complete data were available for 2,381 of 2,447 participants. One hundred and sixty-three participants (6.7%) were lost to follow-up. Participants who received treatment in the U.S. were more likely to be lost to follow-up than those who received treatment in other countries (odds ratio [OR] = 3.56, 95% confidence interval [CI]: 2.46 to 5.17, p < 0.001). Male sex (OR = 1.75, 95% CI: 1.15 to 2.67, p = 0.009), current smoking (OR = 1.82, 95% CI: 1.28 to 2.58, p = 0.001), high-risk alcohol consumption (OR = 1.88, 95% CI: 1.16 to 3.05, p = 0.010), and an age of <30 years (OR = 2.16, 95% CI: 1.19 to 3.95, p = 0.012) all significantly increased the odds of a patient being lost to follow-up. Conversely, participants who had sustained polytrauma (OR = 0.52, 95% CI: 0.37 to 0.73, p < 0.001) or had a Gustilo-Anderson type-IIIA, B, or C fracture (OR = 0.60, 95% CI: 0.38 to 0.94, p = 0.024) had lower odds of being lost to follow-up. CONCLUSIONS: Using a number of strategies, we were able to reduce the loss-to-follow-up rate to <7%. Males, current smokers, young participants, participants who consumed a high-risk amount of alcohol, and participants in the U.S. were more likely to be lost to follow-up even after these strategies had been employed; therefore, additional strategies should be developed to target these high-risk participants. CLINICAL RELEVANCE: This study highlights an important need to develop additional strategies to minimize loss to follow-up, including targeted participant-retention strategies. Male sex, an age of <30 years, current smoking, high-risk alcohol consumption, and treatment in a developed country with a predominantly privately funded health-care system increased the likelihood of participants being lost to follow-up. Therefore, strategies should be targeted to these participants. Use of the planning and prevention strategies outlined in the current study can minimize loss to follow-up in orthopaedic trials.
[Mh] Termos MeSH primário: Fraturas Ósseas/cirurgia
Fraturas Expostas/cirurgia
Perda de Seguimento
Infecção da Ferida Cirúrgica/prevenção & controle
Irrigação Terapêutica/métodos
[Mh] Termos MeSH secundário: Adulto
Extremidades
Feminino
Seres Humanos
Masculino
Meia-Idade
Pressão
Projetos de Pesquisa
Sabões
Cloreto de Sódio
Resultado do Tratamento
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Soaps); 451W47IQ8X (Sodium Chloride)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170706
[St] Status:MEDLINE
[do] DOI:10.2106/JBJS.16.00900


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[PMID]:28504614
[Au] Autor:Jensen DA; Macinga DR; Shumaker DJ; Bellino R; Arbogast JW; Schaffner DW
[Ad] Endereço:1 Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, New Jersey 08901-8520.
[Ti] Título:Quantifying the Effects of Water Temperature, Soap Volume, Lather Time, and Antimicrobial Soap as Variables in the Removal of Escherichia coli ATCC 11229 from Hands.
[So] Source:J Food Prot;80(6):1022-1031, 2017 Jun.
[Is] ISSN:1944-9097
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The literature on hand washing, while extensive, often contains conflicting data, and key variables are only superficially studied or not studied at all. Some hand washing recommendations are made without scientific support, and agreement between recommendations is limited. The influence of key variables such as soap volume, lather time, water temperature, and product formulation on hand washing efficacy was investigated in the present study. Baseline conditions were 1 mL of a bland (nonantimicrobial) soap, a 5-s lather time, and 38°C (100°F) water temperature. A nonpathogenic strain of Escherichia coli (ATCC 11229) was the challenge microorganism. Twenty volunteers (10 men and 10 women) participated in the study, and each test condition had 20 replicates. An antimicrobial soap formulation (1% chloroxylenol) was not significantly more effective than the bland soap for removing E. coli under a variety of test conditions. Overall, the mean reduction was 1.94 log CFU (range, 1.83 to 2.10 log CFU) with the antimicrobial soap and 2.22 log CFU (range, 1.91 to 2.54 log CFU) with the bland soap. Overall, lather time significantly influenced efficacy in one scenario, in which a 0.5-log greater reduction was observed after 20 s with bland soap compared with the baseline wash (P = 0.020). Water temperature as high as 38°C (100°F) and as low as 15°C (60°F) did not have a significant effect on the reduction of bacteria during hand washing; however, the energy usage differed between these temperatures. No significant differences were observed in mean log reductions experienced by men and women (both 2.08 log CFU; P = 0.988). A large part of the variability in the data was associated with the behaviors of the volunteers. Understanding what behaviors and human factors most influence hand washing may help researchers find techniques to optimize the effectiveness of hand washing.
[Mh] Termos MeSH primário: Escherichia coli/efeitos dos fármacos
Desinfecção das Mãos
Sabões/farmacologia
[Mh] Termos MeSH secundário: Anti-Infecciosos
Contagem de Colônia Microbiana
Mãos/microbiologia
Seres Humanos
Temperatura Ambiente
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Soaps); 059QF0KO0R (Water)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170516
[St] Status:MEDLINE
[do] DOI:10.4315/0362-028X.JFP-16-370



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