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[PMID]:27484710
[Au] Autor:Lau JK; So HT; Chiang TK; Cho P
[Ad] Endereço:School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China. Electronic address: kklau@polyu.edu.hk.
[Ti] Título:Effect of multipurpose solutions on in vivo surface wettability of a silicone hydrogel lens.
[So] Source:Cont Lens Anterior Eye;39(6):461-465, 2016 Dec.
[Is] ISSN:1476-5411
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To compare the in vivo surface wettability of silicone hydrogel (SiHy) contact lenses pre-soaked overnight in different multipurpose solutions (MPS) and normal saline. METHODS: In this double-blinded, randomized and self-controlled study, 36 subjects were fitted with three pairs of contact lenses (senofilcon A) pre-soaked overnight in five different MPS and saline in a randomized order. Each pair of lenses (pre-soaked in two different solutions the night before) were worn for 15min before assessment of pre-lens non-invasive tear break-up time (PL-NITBUT) using the Medmont corneal topographer (video recording). Corneal integrity was assessed using a slit lamp and a resting interval of 20min was allowed between each pair of lenses to ensure post-lens wear corneal integrity. RESULTS: Thirty subjects completed the study. The median PL-NITBUT ranged from 2.84s to 3.08s with lenses pre-soaked in different MPS, compared to 2.78s with lenses pre-soaked in saline. No significant differences in PL-NITBUT were found among lenses pre-soaked in different solutions (p=0.647). CONCLUSION: In vivo surface wettability, in terms of PL-NITBUT after 15min of lens wear, of senofilcon A contact lenses pre-soaked overnight in different MPS were not significantly different from those pre-soaked in saline.
[Mh] Termos MeSH primário: Soluções para Lentes de Contato/química
Lentes de Contato Hidrofílicas
Ajuste de Prótese/métodos
Géis de Silicone/química
Lágrimas/química
Agentes Molhantes/química
[Mh] Termos MeSH secundário: Adulto
Método Duplo-Cego
Desenho de Equipamento
Análise de Falha de Equipamento
Feminino
Seres Humanos
Hidrogéis/química
Masculino
Teste de Materiais
Molhabilidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Contact Lens Solutions); 0 (Hydrogels); 0 (Silicone Gels); 0 (Wetting Agents)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160804
[St] Status:MEDLINE


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[PMID]:27054738
[Au] Autor:Fath A; Sacher F; McCaskie JE
[Ad] Endereço:University of Applied Sciences Furtwangen D-78054 Villingen-Schwenningen Germany and Hansgrohe SE 77761 Schiltach Germany.
[Ti] Título:Electrochemical decomposition of fluorinated wetting agents in plating industry waste water.
[So] Source:Water Sci Technol;73(7):1659-66, 2016.
[Is] ISSN:0273-1223
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Electrochemical decomposition of fluorinated surfactants (PFAS, perfluorinated alkyl substances) used in the plating industry was analyzed and the decomposition process parameters optimized at the laboratory scale and production scale of a 500-liter reactor using lead electrodes. The method and system was successfully demonstrated under production conditions to treat PFAS) with up to 99% efficiency in the concentration range of 1,000-20,000 µg/l (1 ppm-20 ppm). The treatment also reduced hexavalent chromium (Cr(6+)) ions to trivalent chromium (Cr(3+)) ions in the wastewater. If the PFAS-containing wastewater is mixed with other wastewater streams, specifically from nickel plating drag out solution or when pH values >5, the treatment process is ineffective. For the short chain PFAS, (perfluorobutylsulfonate) the process was less efficient than C6-C8 PFAS. The process is automated and has safety procedures and controls to prevent hazards. The PFAS were decomposed to hydrogen fluoride (HF) under the strong acid electrochemical operating conditions. Analytical tests showed no evidence of organic waste products remaining from the process. Conventional alternative PFAS removal systems were tested on the waste streams and compared with each other and with the-E-destruct (electrochemical oxidation) process. For example, ion exchange resin (IX resin) treatment of wastewater to complex and remove PFAS was found to be seven times more efficient when compared to the conventional activated carbon absorption (C-treat) process. However, the E-destruct process is higher in capacity, exhibits longer service life and lower operating costs than either IX or C-treat methods for elimination of PFAS from these electroplating waste streams.
[Mh] Termos MeSH primário: Técnicas Eletroquímicas
Compostos de Flúor/química
Resíduos Industriais/análise
Águas Residuais/química
Poluentes Químicos da Água/química
Agentes Molhantes/química
[Mh] Termos MeSH secundário: Cromo
Galvanoplastia
Resinas de Troca Iônica/química
Níquel
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Fluorine Compounds); 0 (Industrial Waste); 0 (Ion Exchange Resins); 0 (Waste Water); 0 (Water Pollutants, Chemical); 0 (Wetting Agents); 0R0008Q3JB (Chromium); 18540-29-9 (chromium hexavalent ion); 7OV03QG267 (Nickel)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:160408
[Lr] Data última revisão:
160408
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160408
[St] Status:MEDLINE
[do] DOI:10.2166/wst.2015.650


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[PMID]:26372476
[Au] Autor:Guzman-Aranguez A; Fonseca B; Carracedo G; Martin-Gil A; Martinez-Aguila A; Pintor J
[Ad] Endereço:Department of Biochemistry and Molecular Biology IV (A.G.-A., B.F., A.M.-G., A.M.-A., J.P.), Faculty of Optic and Optometry, Universidad Complutense de Madrid, Madrid, Spain; and Department of Optics II (Optometry and Vision) (G.C.), Faculty of Optic and Optometry, Universidad Complutense de Madrid, Madrid, Spain.
[Ti] Título:Dry Eye Treatment Based on Contact Lens Drug Delivery: A Review.
[So] Source:Eye Contact Lens;42(5):280-8, 2016 Sep.
[Is] ISSN:1542-233X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Dry eye disease affects a substantial segment of the word population with increasing frequency. It is a multifactorial disease of the ocular surface and tear film, which causes ocular discomfort, visual disturbances, and tear instability with potential damage to the cornea and conjunctiva. Because of its multifactorial etiology, the use of different pharmacological treatment for dry eye treatment has been proposed, which include anti-inflammatory molecules, lubricants or comfort agents, and secretagogues. However, in some cases these pharmacological approaches only relieve symptoms temporarily, and consequently, eye care professionals continue to have difficulties managing dry eye. To improve pharmacological therapy that allows a more efficient and long-term action, effective ocular drug delivery of the currently available drugs for dry eye treatment is required. Contact lenses are emerging as alternative ophthalmic drugs delivery systems that provide an increased residence time of the drug at the eye, thus leading to enhanced bioavailability and more convenient and efficacious therapy. In this article, we reviewed the different techniques used to prepare contact lens-based drug delivery systems and focused on articles that describe the delivery of compounds for dry eye treatment through contact lenses.
[Mh] Termos MeSH primário: Anti-Inflamatórios/administração & dosagem
Lentes de Contato
Sistemas de Liberação de Medicamentos/métodos
Síndromes do Olho Seco/tratamento farmacológico
Soluções Oftálmicas/administração & dosagem
Agentes Molhantes/administração & dosagem
[Mh] Termos MeSH secundário: Disponibilidade Biológica
Túnica Conjuntiva/efeitos dos fármacos
Córnea/efeitos dos fármacos
Fosfatos de Dinucleosídeos/administração & dosagem
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Dinucleoside Phosphates); 0 (Ophthalmic Solutions); 0 (Wetting Agents)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170503
[Lr] Data última revisão:
170503
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150916
[St] Status:MEDLINE
[do] DOI:10.1097/ICL.0000000000000184


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[PMID]:26274401
[Au] Autor:Artz DR; Pitts-Singer TL
[Ad] Endereço:USDA-Agricultural Research Service, Pollinating Insect Research Unit, Logan, Utah, United States of America.
[Ti] Título:Effects of Fungicide and Adjuvant Sprays on Nesting Behavior in Two Managed Solitary Bees, Osmia lignaria and Megachile rotundata.
[So] Source:PLoS One;10(8):e0135688, 2015.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:There is a growing body of empirical evidence showing that wild and managed bees are negatively impacted by various pesticides that are applied in agroecosystems around the world. The lethal and sublethal effects of two widely used fungicides and one adjuvant were assessed in cage studies in California on blue orchard bees, Osmia lignaria, and in cage studies in Utah on alfalfa leafcutting bees, Megachile rotundata. The fungicides tested were Rovral 4F (iprodione) and Pristine (mixture of pyraclostrobin + boscalid), and the adjuvant tested was N-90, a non-ionic wetting agent (90% polyethoxylated nonylphenol) added to certain tank mixtures of fungicides to improve the distribution and contact of sprays to plants. In separate trials, we erected screened cages and released 20 paint-marked females plus 30-50 males per cage to document the behavior of nesting bees under treated and control conditions. For all females in each cage, we recorded pollen-collecting trip times, nest substrate-collecting trip times (i.e., mud for O. lignaria and cut leaf pieces for M. rotundata), cell production rate, and the number of attempts each female made to enter her own or to enter other nest entrances upon returning from a foraging trip. No lethal effects of treatments were observed on adults, nor were there effects on time spent foraging for pollen and nest substrates and on cell production rate. However, Rovral 4F, Pristine, and N-90 disrupted the nest recognition abilities of O. lignaria females. Pristine, N-90, and Pristine + N-90 disrupted nest recognition ability of M. rotundata females. Electroantennogram responses of antennae of O. lignaria females maintained in the laboratory did not differ significantly between the fungicide-exposed and control bees. Our results provide the first empirical evidence that two commonly used fungicides and a non-ionic adjuvant can disrupt nest recognition in two managed solitary bee species.
[Mh] Termos MeSH primário: Fungicidas Industriais/toxicidade
Himenópteros/efeitos dos fármacos
Himenópteros/fisiologia
Comportamento de Nidação/efeitos dos fármacos
Fenóis/toxicidade
Agentes Molhantes/toxicidade
[Mh] Termos MeSH secundário: Agricultura
Aminoimidazol Carboxamida/análogos & derivados
Aminoimidazol Carboxamida/toxicidade
Animais
Compostos de Bifenilo/toxicidade
California
Carbamatos/toxicidade
Feminino
Hidantoínas/toxicidade
Masculino
Niacinamida/análogos & derivados
Niacinamida/toxicidade
Pirazóis/toxicidade
Estrobilurinas
Utah
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Biphenyl Compounds); 0 (Carbamates); 0 (Fungicides, Industrial); 0 (Hydantoins); 0 (N-90 compound); 0 (Phenols); 0 (Pyrazoles); 0 (Strobilurins); 0 (Wetting Agents); 25X51I8RD4 (Niacinamide); 32MS8ZRD1V (2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide); 360-97-4 (Aminoimidazole Carboxamide); DJW8M9OX1H (pyrachlostrobin); S3AYV2A6EU (iprodione)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150815
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0135688


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[PMID]:25891117
[Au] Autor:Fukuoka T; Yoshida S; Nakamura J; Koitabashi M; Sakai H; Abe M; Kitamoto D; Kitamoto H
[Ad] Endereço:Research Institute for Innovation in Sustainable Chemistry, National Institute of Advanced Industrial Science and Technology (AIST).
[Ti] Título:Application of yeast glycolipid biosurfactant, mannosylerythritol lipid, as agrospreaders.
[So] Source:J Oleo Sci;64(6):689-95, 2015.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The spreading property of mannosylerythritol lipids (MELs) was investigated in connection with our search for new application in agriculture. The wetting ability of MEL solutions for hydrophobic surfaces was evaluated based on contact angle measurements for several surfactant solutions on abiotic and biotic surfaces. The contact angle of MEL-A solution on a hydrophobic plastic surface at 100 s after placement decreased to 8.4°, and those of other MEL solutions decreased more significantly compared to those of commonly-used nonionic surfactants. In addition, the contact angle of MEL solutions also dropped down to around 10° on various plant leaf surfaces. MEL solutions, in particular, efficiently spread even on poorly wettable Gramineae plant surfaces on which general nonionic surfactant solutions could not. Moreover, the wetting ability of MEL solutions was found to be greatly affected by the structural difference in their carbohydrate configuration. Furthermore, surface pretreatment with MEL solution led to more efficient spreading and fixing of microbial cells onto plant leaf surface compared to several conventional surfactants used in this study. These results suggested that MELs have a potential to use as a natural bio-based spreading agent, particularly as agrochemical spreader for biopesticides.
[Mh] Termos MeSH primário: Glicolipídeos/química
Agentes Molhantes/química
[Mh] Termos MeSH secundário: Agroquímicos
Agentes de Controle Biológico
Configuração de Carboidratos
Interações Hidrofóbicas e Hidrofílicas
Folhas de Planta
Soluções
Relação Estrutura-Atividade
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Agrochemicals); 0 (Biological Control Agents); 0 (Glycolipids); 0 (Solutions); 0 (Wetting Agents); 0 (mannosylerythritol lipid)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:150601
[Lr] Data última revisão:
150601
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150421
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess15017


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[PMID]:25772920
[Au] Autor:Yildiz E; Karaarslan ES; Simsek M; Cebe F; Ozsevik AS; Ozturk B
[Ad] Endereço:Department of Pediatric Dentistry, University of Akdeniz, Antalya, Turkey.
[Ti] Título:Effect of a re-wetting agent on bond strength of an adhesive to primary and permanent teeth dentin after different etching techniques.
[So] Source:Niger J Clin Pract;18(3):364-70, 2015 May-Jun.
[Is] ISSN:1119-3077
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: This study investigated the effect of a re-wetting agent on the microtensile bond strengths (mTBS) of primary and permanent dentin after acid or laser etching. MATERIALS AND METHODS: Twelve permanent and 12 primary molar teeth were ground to expose an occlusal dentin surface. Each group teeth were randomly divided into groups; I-II: 37% phosphoric acid etching with/without re-wetting agent, III-IV: Erbium: Yttrium aluminium garnet laser etching with/without re-wetting agent. An etch-and-rinse adhesive was used, and vertical sticks were obtained for the microtensile test. RESULTS: mTBS of permanent teeth was higher than that of primary teeth (P < 0.05). Re-wetting agent groups were similar with control groups in both etching groups in the permanent teeth (P > 0.05). Re-wetting agent group was similar with the control group in acid etch group (P > 0.05) and lower than the control group in laser etch group in primary teeth (P < 0.05). CONCLUSION: Acid etching in permanent teeth; laser etching in primary teeth was found more successful. The use of re-wetting agent did not provide an advance on bond strength of the adhesive in both primary and permanent teeth after acid-etch or laser-etch.
[Mh] Termos MeSH primário: Ataque Ácido Dentário/métodos
Adesivos Dentinários/química
Agentes Molhantes/química
[Mh] Termos MeSH secundário: Dentina/química
Seres Humanos
Dente Molar/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Dentin-Bonding Agents); 0 (Wetting Agents)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:150316
[Lr] Data última revisão:
150316
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150317
[St] Status:MEDLINE
[do] DOI:10.4103/1119-3077.151786


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[PMID]:25343282
[Au] Autor:Haidara H
[Ad] Endereço:Institut de Science des Matériaux de Mulhouse (IS2M), UMR 7361-CNRS/Université de Haute Alsace, 15 rue Jean Starcky, 68057 Mulhouse Cedex, France. hamidou.haidara@uha.fr.
[Ti] Título:Wetting-mediated collective tubulation and pearling in confined vesicular drops of DDAB solutions.
[So] Source:Soft Matter;10(47):9460-9, 2014 Dec 21.
[Is] ISSN:1744-6848
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Whether driven by external mechanical stresses (shear flow) or induced by membrane-active peptides and/or proteins, the collective growth of tubules in membranous fluids has seldom been reported. The pearling destabilization of these membranous tubules which requires an activation of the shape distortion, often induced by optical tweezers, membrane-active biomolecules or an electrical field, has also rarely been observed under mild experimental conditions. Here we report such events of collective tubulation and pearling destabilization in sessile drops of a didodecyl-dimethylammonium bromide (DDAB) vesicular solution that are confined by a surrounding oil medium. Based on the wetting dynamics and the features of the tubulation process, we show that the growth of the tubules here relies on a mechanism of "pinning-induced pulling" from the retracting drop, rather than the classical hydrodynamic fingering instability. We show that the whole tubulation process is driven by a strong coupling between the bulk properties of the ternary (DAAB/water/oil) system and the dynamics of wetting. Finally, we discuss the pearling destabilization of these tubules under vanishing static interface tension and quite mild tensile force arising from their pulling. We show that under those mild conditions, shape disturbances readily grow, either as pearling waves moving toward the drop-reservoir or as Rayleigh-type peristaltic modulations. Besides revealing singular non-Rayleigh pearling modes, this work also brings new insights into the flow dynamics in membranous tubules anchored to an infinite reservoir.
[Mh] Termos MeSH primário: Modelos Químicos
Compostos de Amônio Quaternário/química
Agentes Molhantes/química
[Mh] Termos MeSH secundário: Alcanos/química
Fenômenos Químicos
Cinética
Fenômenos Mecânicos
Microscopia de Vídeo
Óleos/química
Reologia/métodos
Silício/química
Soluções
Esqualeno/análogos & derivados
Esqualeno/química
Tensão Superficial
Resistência à Tração
Viscosidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkanes); 0 (Oils); 0 (Quaternary Ammonium Compounds); 0 (Solutions); 0 (Wetting Agents); 11A386X1QH (n-dodecane); 13146-86-6 (didodecyldimethylammonium); 7QWM220FJH (Squalene); F8Z00SHP6Q (n-hexadecane); GW89575KF9 (squalane); Z4152N8IUI (Silicon)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141025
[St] Status:MEDLINE
[do] DOI:10.1039/c4sm01579g


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[PMID]:24913168
[Au] Autor:Ball C; Woodrow KA
[Ad] Endereço:University of Washington, Seattle, Washington, USA.
[Ti] Título:Electrospun solid dispersions of Maraviroc for rapid intravaginal preexposure prophylaxis of HIV.
[So] Source:Antimicrob Agents Chemother;58(8):4855-65, 2014 Aug.
[Is] ISSN:1098-6596
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The development of topical anti-human immunodeficiency virus (HIV) microbicides may provide women with strategies to protect themselves against sexual HIV transmission. Pericoital drug delivery systems intended for use immediately before sex, such as microbicide gels, must deliver high drug doses for maximal effectiveness. The goal of achieving a high antiretroviral dose is complicated by the need to simultaneously retain the dose and quickly release drug compounds into the tissue. For drugs with limited solubility in vaginal gels, increasing the gel volume to increase the dose can result in leakage. While solid dosage forms like films and tablets increase retention, they often require more than 15 min to fully dissolve, potentially increasing the risk of inducing epithelial abrasions during sex. Here, we demonstrate that water-soluble electrospun fibers, with their high surface area-to-volume ratio and ability to disperse antiretrovirals, can serve as an alternative solid dosage form for microbicides requiring both high drug loading and rapid hydration. We formulated maraviroc at up to 28 wt% into electrospun solid dispersions made from either polyvinylpyrrolidone or poly(ethylene oxide) nanofibers or microfibers and investigated the role of drug loading, distribution, and crystallinity in determining drug release rates into aqueous media. We show here that water-soluble electrospun materials can rapidly release maraviroc upon contact with moisture and that drug delivery is faster (less than 6 min under sink conditions) when maraviroc is electrospun in polyvinylpyrrolidone fibers containing an excipient wetting agent. These materials offer an alternative dosage form to current pericoital microbicides.
[Mh] Termos MeSH primário: Fármacos Anti-HIV/química
Anti-Infecciosos Locais/química
Cicloexanos/química
Suspensões/química
Triazóis/química
Cremes, Espumas e Géis Vaginais/química
[Mh] Termos MeSH secundário: Administração Intravaginal
Fármacos Anti-HIV/farmacologia
Anti-Infecciosos Locais/farmacologia
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Cicloexanos/farmacologia
Técnicas Eletroquímicas
Excipientes/química
Feminino
Infecções por HIV/prevenção & controle
Seres Humanos
Cinética
Nanofibras/química
Nanofibras/ultraestrutura
Polietilenoglicóis/química
Polissorbatos/química
Povidona/química
Suspensões/farmacologia
Triazóis/farmacologia
Cremes, Espumas e Géis Vaginais/farmacologia
Molhabilidade
Agentes Molhantes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Anti-HIV Agents); 0 (Anti-Infective Agents, Local); 0 (Cyclohexanes); 0 (Excipients); 0 (Polysorbates); 0 (Suspensions); 0 (Triazoles); 0 (Vaginal Creams, Foams, and Jellies); 0 (Wetting Agents); 30IQX730WE (Polyethylene Glycols); FZ989GH94E (Povidone); MD6P741W8A (maraviroc)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140611
[St] Status:MEDLINE
[do] DOI:10.1128/AAC.02564-14


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[PMID]:24835175
[Au] Autor:Beaune G; Stirbat TV; Khalifat N; Cochet-Escartin O; Garcia S; Gurchenkov VV; Murrell MP; Dufour S; Cuvelier D; Brochard-Wyart F
[Ad] Endereço:University Pierre and Marie Curie, University of Paris, Institut Curie, 75248 Paris Cedex 05, France;Centre National de la Recherche Scientifique, Unité Mixte de Recherche, Unité Mixte de Recherche 168, Institut Curie, 75248 Paris Cedex 05, France;
[Ti] Título:How cells flow in the spreading of cellular aggregates.
[So] Source:Proc Natl Acad Sci U S A;111(22):8055-60, 2014 Jun 03.
[Is] ISSN:1091-6490
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Like liquid droplets, cellular aggregates, also called "living droplets," spread onto adhesive surfaces. When deposited onto fibronectin-coated glass or polyacrylamide gels, they adhere and spread by protruding a cellular monolayer (precursor film) that expands around the droplet. The dynamics of spreading results from a balance between the pulling forces exerted by the highly motile cells at the periphery of the film, and friction forces associated with two types of cellular flows: (i) permeation, corresponding to the entry of the cells from the aggregates into the film; and (ii) slippage as the film expands. We characterize these flow fields within a spreading aggregate by using fluorescent tracking of individual cells and particle imaging velocimetry of cell populations. We find that permeation is limited to a narrow ring of width ξ (approximately a few cells) at the edge of the aggregate and regulates the dynamics of spreading. Furthermore, we find that the subsequent spreading of the monolayer depends heavily on the substrate rigidity. On rigid substrates, the migration of the cells in the monolayer is similar to the flow of a viscous liquid. By contrast, as the substrate gets softer, the film under tension becomes unstable with nucleation and growth of holes, flows are irregular, and cohesion decreases. Our results demonstrate that the mechanical properties of the environment influence the balance of forces that modulate collective cell migration, and therefore have important implications for the spreading behavior of tissues in both early development and cancer.
[Mh] Termos MeSH primário: Adesão Celular/fisiologia
Comunicação Celular/fisiologia
Movimento Celular/fisiologia
Modelos Biológicos
Sarcoma/patologia
[Mh] Termos MeSH secundário: Resinas Acrílicas
Adesivos
Animais
Caderinas/metabolismo
Linhagem Celular Tumoral
Progressão da Doença
Fricção
Proteínas de Fluorescência Verde/metabolismo
Lipídeo A/análogos & derivados
Proteínas Luminescentes/metabolismo
Mecanotransdução Celular/fisiologia
Camundongos
Microscopia Confocal/métodos
Sarcoma/metabolismo
Agentes Molhantes
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acrylic Resins); 0 (Adhesives); 0 (Cadherins); 0 (Lipid A); 0 (Luminescent Proteins); 0 (Wetting Agents); 0 (polyacrylamide gels); 0 (red fluorescent protein); 147336-22-9 (Green Fluorescent Proteins); 89756-57-0 (GLA 27)
[Em] Mês de entrada:1408
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140520
[St] Status:MEDLINE
[do] DOI:10.1073/pnas.1323788111


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[PMID]:24355830
[Au] Autor:Wang H; Wang CQ; Fu JG; Gu GH
[Ad] Endereço:School of Chemistry and Chemical Engineering, Key Laboratory of Resources Chemistry of Nonferrous Metals, Ministry of Education, Central South University, Changsha, 410083 Hunan, China. Electronic address: huiwang1968@163.com.
[Ti] Título:Flotability and flotation separation of polymer materials modulated by wetting agents.
[So] Source:Waste Manag;34(2):309-15, 2014 Feb.
[Is] ISSN:1879-2456
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The surface free energy, surface tension and contact angles were performed to investigate the properties of wetting agents. Adsorption of wetting agents changes wetting behavior of polymer resins. Flotability of polymer materials modulated by wetting agents was studied, and wetting agents change significantly flotability of polymer materials. The flotability decreases with increasing the concentration of wetting agents, and the wetting ability is lignin sulfonate (LS)>tannic acid (TA)>methylcellulose (MC)>triton X-100 (TX-100) (from strong to weak). There is significant difference in the flotability between polymer resins and plastics due to the presence of additives in the plastics. Flotation separation of two-component and multicomponent plastics was conducted based on the flotability modulated by wetting agents. The two-component mixtures can be efficiently separated using proper wetting agent through simple flotation flowsheet. The multicomponent plastic mixtures can be separated efficiently through multi-stage flotation using TA and LS as wetting agents, and the purity of separated component was above 94%, and the recovery was more than 93%.
[Mh] Termos MeSH primário: Teste de Materiais/métodos
Polímeros/química
Eliminação de Resíduos/métodos
Resíduos/análise
Agentes Molhantes/química
[Mh] Termos MeSH secundário: Adsorção
Lignina
Metilcelulose
Octoxinol
Taninos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Polymers); 0 (Tannins); 0 (Waste Products); 0 (Wetting Agents); 8068-05-1 (Kraft lignin); 9002-93-1 (Octoxynol); 9004-67-5 (Methylcellulose); 9005-53-2 (Lignin)
[Em] Mês de entrada:1409
[Cu] Atualização por classe:140120
[Lr] Data última revisão:
140120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131221
[St] Status:MEDLINE



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