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[PMID]:29381301
[Au] Autor:Tyshko NV; Zaponova AA; Zaigrin IV; Nikitin NS
[Ti] Título:[Investigation of the liver DNA methylation profile of rats under the influence of hepatotoxicants of different nature].
[So] Source:Vopr Pitan;85(5):44-51, 2016.
[Is] ISSN:0042-8833
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The functional importance of DNA methylation, which is a special case of epigenetic variation, is meant for regulation of many biological processes, ranged from tissue specific gene expression to remodeling of chromatin structure. Disorders of the DNA methylation can cause changes in the cell's phenotype, providing a significant impact on the development of pathology. Both exogenous and endogenous factors are able to cause disruption of DNA methylation, while epigenetic changes usually precede the emergence of clinical and morphological symptoms of pathological process development, consequently the parameters of DNA methylation can be used as sensitive biomarkers to detect adverse effects on the organism. The purpose of the study was to identify genes of the liver, the methylation profile of which changes under the influence of hepatotoxicants of different nature. The experiment was carried out on 60 male Wistar rats with initial body weight (b.w.) 83.3±1.5 g. Animals were randomly divided into 6 groups - 1 control and 5 test groups, with 10 rats in each group. During the first two weeks of the experiment the rats of the 1-5th test groups were administered to aflatoxin B1 (200 Mg/kg b.w.), cadmium chloride 2,5-hydrate (2 mg/kg), monosodium glutamate (1000 mg/kg), epigallocatechin gallate (EGCG) (1000 mg/kg), paracetamol (150 mg/kg), accordingly. Methylation of the liver genes in rats was determined by using high-performance methods, based on bisulfite sequencing of reduced representation. For each sample from 12 to 30 million pairs of reads were received, genes which demonstrated significant changes in methylation when exposed to toxic factors were identified: aflatoxin B1 caused changes in the methylation of 57 genes; cadmium - 54 genes; monosodium glutamate - 39 genes; EGCG -198 genes; paracetamol - 167 genes. The comparison of genes with altered methylation in the experimental groups revealed that none of the genes repeatedly occurred under the influence of each toxicant out of five, the highest number of repeats accounted 3. As a result of the present analysis 7 genes have been selected: methylation change in Fan1 gene was observed when exposed to cadmium, monosodium glutamate, EGCG; gene Lppr2 - under the influence of aflatoxin B1, EGCG, paracetamol; gene Mlh3 - under the influence of aflatoxin B1, cadmium, paracetamol; Sirt7 gene - under the influence of cadmium, EGCG, paracetamol; gene Fbxo15 - when exposed to cadmium, monosodium glutamate, paracetamol; gene E2f1 - when exposed to cadmium, EGCG, paracetamol; gene Mrps16 - when exposed to cadmium, EGCG, paracetamol. On the basis of the received data the project of the panel of genes-biomarkers of toxic effect, including genes Fan1, Lppr2, Mlh3, Sirt7, Fbxo15, E2f1, Mrps16 has been formed.
[Mh] Termos MeSH primário: Doença Hepática Induzida por Substâncias e Drogas/metabolismo
Metilação de DNA/efeitos dos fármacos
Regulação da Expressão Gênica/efeitos dos fármacos
Fígado/metabolismo
Noxas/toxicidade
[Mh] Termos MeSH secundário: Animais
Doença Hepática Induzida por Substâncias e Drogas/patologia
Fígado/patologia
Masculino
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Noxae)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180131
[St] Status:MEDLINE


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[PMID]:28424313
[Au] Autor:Lopez-Luna J; Al-Jubouri Q; Al-Nuaimy W; Sneddon LU
[Ad] Endereço:Department of Evolution, Ecology and Behaviour, Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK jlopez@liverpool.ac.uk.
[Ti] Título:Reduction in activity by noxious chemical stimulation is ameliorated by immersion in analgesic drugs in zebrafish.
[So] Source:J Exp Biol;220(Pt 8):1451-1458, 2017 Apr 15.
[Is] ISSN:1477-9145
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Research has recently demonstrated that larval zebrafish show similar molecular responses to nociception to those of adults. Our study explored whether unprotected larval zebrafish exhibited altered behaviour after exposure to noxious chemicals and screened a range of analgesic drugs to determine their efficacy to reduce these responses. This approach aimed to validate larval zebrafish as a reliable replacement for adults as well as providing a high-throughput means of analysing behavioural responses. Zebrafish at 5 days post-fertilization were exposed to known noxious stimuli: acetic acid (0.01%, 0.1% and 0.25%) and citric acid (0.1%, 1% and 5%). The behavioural response of each was recorded and analysed using novel tracking software that measures time spent active in 25 larvae at one time. Subsequently, the efficacy of aspirin, lidocaine, morphine and flunixin as analgesics after exposure to 0.1% acetic acid was tested. Larvae exposed to 0.1% and 0.25% acetic acid spent less time active, whereas those exposed to 0.01% acetic acid and 0.1-5% citric acid showed an increase in swimming activity. Administration of 2.5 mg l aspirin, 5 mg l lidocaine and 48 mg l morphine prevented the behavioural changes induced by acetic acid. These results suggest that larvae respond to a noxious challenge in a similar way to adult zebrafish and other vertebrates and that the effect of nociception on activity can be ameliorated by using analgesics. Therefore, adopting larval zebrafish could represent a direct replacement of a protected adult fish with a non-protected form in pain- and nociception-related research.
[Mh] Termos MeSH primário: Ácido Acético/farmacologia
Analgésicos/farmacologia
Comportamento Animal/efeitos dos fármacos
Ácido Cítrico/farmacologia
Nociceptividade/efeitos dos fármacos
Noxas/farmacologia
Peixe-Zebra/fisiologia
[Mh] Termos MeSH secundário: Animais
Aspirina/farmacologia
Clonixino/análogos & derivados
Clonixino/farmacologia
Avaliação Pré-Clínica de Medicamentos/métodos
Larva/efeitos dos fármacos
Larva/fisiologia
Lidocaína/farmacologia
Morfina/farmacologia
Estimulação Química
Natação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Noxae); 2968PHW8QP (Citric Acid); 356IB1O400 (flunixin); 76I7G6D29C (Morphine); 98PI200987 (Lidocaine); Q40Q9N063P (Acetic Acid); R16CO5Y76E (Aspirin); V7DXN0M42R (Clonixin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170616
[Lr] Data última revisão:
170616
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170421
[St] Status:MEDLINE
[do] DOI:10.1242/jeb.146969


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[PMID]:28069343
[Au] Autor:Sue GR; Karanas YL; Davis DJ; Press B
[Ad] Endereço:Regional Burn Center, Santa Clara Valley Medical Center, San Jose, CA, United States; Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA, United States. Electronic address: gsue@stanford.edu.
[Ti] Título:The unusual presentation of a burn from methyl bromide exposure: A case report and review of the literature.
[So] Source:Burns;43(3):e43-e46, 2017 May.
[Is] ISSN:1879-1409
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Methyl bromide chemical burns are rare. Only two cases have been reported to date. The presentation of methyl bromide chemical burns is unusual. Patients with an acute exposure should be observed closely as the initial presentation can appear deceptively benign. The latency period lasts several hours prior to the development of chemical burn wounds. In this article, we review the literature on methyl bromide chemical burns and present our experience managing a patient with an extensive methyl bromide burn.
[Mh] Termos MeSH primário: Queimaduras Químicas/etiologia
Dermatite Alérgica de Contato/etiologia
Traumatismos do Pé/etiologia
Hidrocarbonetos Bromados/toxicidade
Traumatismos da Perna/etiologia
Noxas/toxicidade
[Mh] Termos MeSH secundário: Administração Cutânea
Corticosteroides/uso terapêutico
Queimaduras Químicas/cirurgia
Dermatite Alérgica de Contato/tratamento farmacológico
Traumatismos do Pé/cirurgia
Seres Humanos
Traumatismos da Perna/cirurgia
Masculino
Meia-Idade
Transplante de Pele
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Hydrocarbons, Brominated); 0 (Noxae); 9V42E1Z7B6 (methyl bromide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170111
[St] Status:MEDLINE


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[PMID]:27624611
[Au] Autor:Chang MJ; Xu YJ; He WX; Zhang CL; Li XP; Liu D
[Ad] Endereço:Center for Translational Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
[Ti] Título:Intestinal injury in the rat model of 17α-ethynylestradiol-induced intrahepatic cholestasis.
[So] Source:J Dig Dis;17(11):756-763, 2016 Nov.
[Is] ISSN:1751-2980
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Although the intimate relationship between liver and gut has been previously reported under physiological and pathological conditions, intestinal involvement in the process of intrahepatic cholestasis of pregnancy remains unclear. The aim of this study was to investigate intestinal changes in 17α-ethynylestradiol (EE)-induced cholestatic rat model. METHODS: Liver injury was assessed by HE stain and serum biochemical parameters were measured. Intestinal transit was determined using ink marks. Neuronal protein expressions in the intestine were analyzed by Western blot. RESULTS: EE treatment induced liver damage, including severe bile duct hyperplasia, portal edema, portal infiltration, a loss of hepatic structure in periportal areas and increased serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and total bilirubin. Large areas of inflammatory cell infiltration and increased myeloperoxidase activity were observed in the intestine of EE-induced cholestatic rats. The EE-treated group showed increased intestinal transit and malondialdehyde levels, while the glutathione content and superoxide dismutase activity were notably decreased, together with decreased protein gene product 9.5 and neuronal nitric oxide synthase expression in the ileum and colon. Furthermore, choline acetyltransferase expression was significantly decreased in the ileum, whereas no change was observed in the colon of EE-treated rats. CONCLUSION: EE-induced liver damage is associated with oxidative stress, inflammation and neural loss in the intestine, which may lead to altered intestinal motility.
[Mh] Termos MeSH primário: Doença Hepática Induzida por Substâncias e Drogas/patologia
Colestase Intra-Hepática/patologia
Etinilestradiol/farmacologia
Enteropatias/patologia
Fígado/patologia
Noxas/farmacologia
[Mh] Termos MeSH secundário: Animais
Doença Hepática Induzida por Substâncias e Drogas/fisiopatologia
Colestase Intra-Hepática/induzido quimicamente
Colestase Intra-Hepática/fisiopatologia
Modelos Animais de Doenças
Etinilestradiol/efeitos adversos
Trânsito Gastrointestinal/efeitos dos fármacos
Enteropatias/induzido quimicamente
Enteropatias/fisiopatologia
Intestinos/efeitos dos fármacos
Intestinos/inervação
Intestinos/patologia
Fígado/efeitos dos fármacos
Fígado/fisiopatologia
Hepatopatias/patologia
Hepatopatias/fisiopatologia
Masculino
Noxas/efeitos adversos
Estresse Oxidativo/efeitos dos fármacos
Estresse Oxidativo/fisiologia
Ratos
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Noxae); 423D2T571U (Ethinyl Estradiol)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170426
[Lr] Data última revisão:
170426
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160915
[St] Status:MEDLINE
[do] DOI:10.1111/1751-2980.12407


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[PMID]:26455567
[Au] Autor:Bahcecioglu IH; Ispiroglu M; Tuzcu M; Orhan C; Ulas M; Demirel U; Yalniz M; Özercan IH; Ilhan N; Sahin K
[Ad] Endereço:Department of Gastroenterology, Firat University Faculty of Medicine, Elazig, Turkey. ihbahcecioglu@yahoo.com.
[Ti] Título:Pistacia Terebinthus Coffee Protects against Thioacetamide-Induced Liver Injury in Rats.
[So] Source:Acta Medica (Hradec Kralove);58(2):56-61, 2015.
[Is] ISSN:1211-4286
[Cp] País de publicação:Czech Republic
[La] Idioma:eng
[Ab] Resumo:AIM/BACKGROUND: Pistacia terebinthus is used as a coffee substitute in the East and Southern Anatolia regions of Turkey. It contains unsaturated fatty acids, tocopherols, polyphenols and carotenoids. P. terebinthus has anti-inflammatory and potential antioxidant activity. In this study we evaluated the protective effects of P. terebinthus coffee (PTC) on thioacetamide (TAA)-induced liver injury in rats. MATERIALS AND METHODS: Twenty-eight male Sprague-Dawley rats were equally randomized into four groups. Chronic liver injury was induced with TAA (100 mg/kg i.p. three times weekly). The first group of rats served as control and received only tap water (G1), and the remaining groups of rats received PTC, p.o (G2); TAA (G3); TAA plus PTC, p.o (G4), respectively. RESULTS: After 8 weeks, PTC intake significantly reduced fibrosis/inflammation scores (p PTC intake reduced transforming growth factor beta (TGF-ß) concentrations in the liver (p PTC intake. DISCUSSION AND CONCLUSION: PTC intake provided beneficial effects against TAA-induced liver injury in rats. PTC probably suppresses the proinflammatory cytokines through NF-κB signaling pathway.
[Mh] Termos MeSH primário: Inflamação/tratamento farmacológico
Cirrose Hepática Experimental
Fígado
Estresse Oxidativo/efeitos dos fármacos
Pistacia
Chás de Ervas
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Animais
Antioxidantes/farmacologia
Modelos Animais de Doenças
Fígado/efeitos dos fármacos
Fígado/metabolismo
Fígado/patologia
Cirrose Hepática Experimental/induzido quimicamente
Cirrose Hepática Experimental/metabolismo
Cirrose Hepática Experimental/fisiopatologia
Cirrose Hepática Experimental/prevenção & controle
Masculino
Noxas/toxicidade
Ratos
Ratos Sprague-Dawley
Tioacetamida/toxicidade
Fator de Crescimento Transformador beta/metabolismo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Noxae); 0 (Teas, Herbal); 0 (Transforming Growth Factor beta); 0 (Triterpenes); 075T165X8M (Thioacetamide)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:161021
[Lr] Data última revisão:
161021
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151013
[St] Status:MEDLINE
[do] DOI:10.14712/18059694.2015.94


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[PMID]:26036264
[Au] Autor:Tomkins J
[Ad] Endereço:American Society of Clinical Oncology, Alexandria, VA.
[Ti] Título:Ensuring Health Care Worker Safety When Handling Hazardous Drugs: The Joint Position Statement From the Oncology Nursing Society, the American Society of Clinical Oncology, and the Hematology/Oncology Pharmacy Association.
[So] Source:J Oncol Pract;11(4):278-9, 2015 Jul.
[Is] ISSN:1935-469X
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Antineoplásicos/toxicidade
Pessoal de Saúde
Noxas/toxicidade
Exposição Ocupacional/prevenção & controle
Saúde do Trabalhador
[Mh] Termos MeSH secundário: Seres Humanos
Política Organizacional
Equipamento de Proteção Individual
Segurança
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Noxae)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:161020
[Lr] Data última revisão:
161020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150604
[St] Status:MEDLINE
[do] DOI:10.1200/JOP.2015.004978


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[PMID]:25549170
[Au] Autor:Hong O; Chin DL; Kerr MJ
[Ad] Endereço:* School of Nursing, University of California San Francisco , California , USA.
[Ti] Título:Lifelong occupational exposures and hearing loss among elderly Latino Americans aged 65-75 years.
[So] Source:Int J Audiol;54 Suppl 1:S57-64, 2015 Feb.
[Is] ISSN:1708-8186
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The purpose of this study is to determine the relationship between occupational exposures and hearing among elderly Latino Americans. DESIGN: A descriptive, correlational design used for this secondary analysis with the data from the Sacramento Area Latino Study of Aging (SALSA). STUDY SAMPLE: A total of 547 older adults were included. RESULTS: A majority of participants (58%) reported occupational exposures to loud noise and/or ototoxic chemicals. About 65% and over 90% showed hearing loss at low and high frequencies, respectively. Participants with occupational exposure to loud noise and/or ototoxic chemicals were, significantly, two times more likely to have hearing loss at high frequencies compared to those without exposure (OR = 2.29; 95% CI: 1.17 = 4.51, p = .016), after controlling for other risk factors of hearing loss such as age, gender, household income, current smoking, and diabetes. However, lifelong occupational exposure was not significantly associated with hearing loss at low frequencies (OR = 1.43; 95% CI: 0.94 = 2.18, p = .094). CONCLUSION: Lifelong occupational exposure to loud noise and/or ototoxic chemicals was significantly associated with hearing loss among elderly Latino Americans. Healthy work life through protection from harmful auditory effects of occupational exposures to noise and chemicals will have a positive impact on better hearing in later life.
[Mh] Termos MeSH primário: Perda Auditiva/epidemiologia
Ruído/efeitos adversos
Noxas/efeitos adversos
Exposição Ocupacional/estatística & dados numéricos
[Mh] Termos MeSH secundário: Idoso
California/epidemiologia
Estudos Transversais
Feminino
Perda Auditiva/etiologia
Seres Humanos
Modelos Logísticos
Masculino
Prevalência
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Noxae)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:161019
[Lr] Data última revisão:
161019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141231
[St] Status:MEDLINE
[do] DOI:10.3109/14992027.2014.973541


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[PMID]:25483969
[Au] Autor:Guo S; Ai W; Fei J; Xu G; Zeng G; Shen Y
[Ad] Endereço:National Key laboratory of Human Factors Engineering, China Astronaut Research and Training Center, Beijing, 100094, China, guoshuangsheng@sina.com.
[Ti] Título:Study on the kinetic characteristics of trace harmful gases for a two-person-30-day integrated CELSS test.
[So] Source:Environ Sci Pollut Res Int;22(9):7020-4, 2015 May.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A two-person-30-day controlled ecological life support system (CELSS) integrated test was carried out, and more than 30 kinds of trace harmful gases including formaldehyde, benzene, and ammonia were measured and analyzed dynamically. The results showed that the kinds and quantities of the trace harmful gases presented a continuously fluctuating state during the experimental period, but none of them exceed the spacecraft maximum allowable concentration (SMAC). The results of the Pre-Test (with two persons without plants for 3 days) and the Test (with two persons and four kinds of plants for 30 days) showed that there are some notable differences for the compositions of the trace harmful gases; the volatile organic compounds (VOCs) such as toluene, hexane, and acetamide were searched out in the Pre-Test, but were not found in the Test. Moreover, the concentrations of the trace harmful gases such as acetic benzene, formaldehyde, and ammonia decreased greatly in the Test more than those in the Pre-Test, which means that the plants can purify these gases efficiently. In addition, the VOCs such as carbon monoxide, cyclopentane, and dichloroethylene were checked out in the Test but none in the Pre-Test, which indicates that these materials might be from the crew's metabolites or those devices in the platform. Additionally, the ethylene released specially by plants accumulated in the later period and its concentration reached nearly ten times of 0.05 mg m(-3) (maximum allowed concentration for plant growth, which must have promoted the later withering of plants). We hoped that the work can play a referring function for controlling VOCs effectively so that future more CELSS integrating tests can be implemented smoothly with more crew, longer period, and higher closure.
[Mh] Termos MeSH primário: Sistemas Ecológicos Fechados
Gases/análise
Noxas/análise
Plantas
[Mh] Termos MeSH secundário: Amônia/análise
Monóxido de Carbono/análise
Chicória
Etilenos/análise
Seres Humanos
Sulfeto de Hidrogênio/análise
Cinética
Alface
Compostos Orgânicos Voláteis/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Ethylenes); 0 (Gases); 0 (Noxae); 0 (Volatile Organic Compounds); 7664-41-7 (Ammonia); 7U1EE4V452 (Carbon Monoxide); 91GW059KN7 (ethylene); YY9FVM7NSN (Hydrogen Sulfide)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141209
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-014-3743-5


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[PMID]:25241751
[Au] Autor:Liu JL; Li XY
[Ad] Endereço:a Department of Civil Engineering, Environmental Engineering Research Centre , The University of Hong Kong , Pokfulam Road, Hong Kong , People's Republic of China.
[Ti] Título:Removal of soluble microbial products as the precursors of disinfection by-products in drinking water supplies.
[So] Source:Environ Technol;36(5-8):722-31, 2015 Mar-Apr.
[Is] ISSN:0959-3330
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Water pollution worsens the problem of disinfection by-products (DBPs) in drinking water supply. Biodegradation of wastewater organics produces soluble microbial products (SMPs), which can be important DBP precursors. In this laboratory study, a number of enhanced water treatment methods for DBP control, including enhanced coagulation, ozonation, and activated carbon adsorption, were evaluated for their effectiveness in treating SMP-containing water for the DBP reduction purpose. The results show that enhanced coagulation with alum could remove SMPs only marginally and decrease the DBP formation potential (DBPFP) of the water by less than 20%. Although ozone could cause destruction of SMPs in water, the overall DBPFP of the water did not decrease but increased after ozonation. In contrast, adsorption by granular activated carbon could remove the SMP organics from water by more than 60% and reduce the DBPFP by more than 70%. It is apparent that enhanced coagulation and ozonation are not suitable for the removal of SMPs as DBP precursors from polluted water, although enhanced coagulation has been commonly used to reduce the DBP formation caused by natural organic matter. In comparison, activated carbon adsorption is shown as a more effective means to remove the SMP content from water and hence to control the wastewater-derived DBP problem in water supply.
[Mh] Termos MeSH primário: Noxas/isolamento & purificação
Compostos Orgânicos/isolamento & purificação
Poluição Química da Água/prevenção & controle
Purificação da Água
[Mh] Termos MeSH secundário: Adsorção
Compostos de Alúmen
Desinfecção
Água Potável
Ozônio
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alum Compounds); 0 (Drinking Water); 0 (Noxae); 0 (Organic Chemicals); 34S289N54E (aluminum sulfate); 66H7ZZK23N (Ozone)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140923
[St] Status:MEDLINE
[do] DOI:10.1080/09593330.2014.960473


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[PMID]:25558740
[Au] Autor:Magrini A; Grana M; Vicentini L
[Ad] Endereço:Dipartimento di Biomedicina e Prevenzione, Università di Roma Tor Vergata, Roma, Italy.
[Ti] Título:[Chemical, physical and biological risks in law enforcement].
[Ti] Título:Rischi chimici, fisici e biologici nelle Forze dell'Ordine..
[So] Source:G Ital Med Lav Ergon;36(4):382-91, 2014 Oct-Dec.
[Is] ISSN:1592-7830
[Cp] País de publicação:Italy
[La] Idioma:spa
[Ab] Resumo:Chemical, physical and biological risks among public safety and security forces. Law enforcement personnel, involved in routine tasks and in emergency situations, are exposed to numerous and several occupational hazards (chemical, physical and biological) whith likely health and security consequences. These risks are particularly high when the organization and preparation are inadequate, there is a lacking or insufficient coordination, information, education and communication and safety and personal protective equipment are inadequate or insufficient. Despite the objective difficulties, caused by the actual special needs related to the service performed or the organizational peculiarities, the risk identification and assessment is essential for worker health and safety of personnel, as provided for by Legislative Decree no. 81/2008. Chemical risks include airborne pollutants due to vehicular traffic (carbon monoxide, ultrafine particles, benzene, polycyclic aromatic hydrocarbons, aldehydes, nitrogen and sulfur oxides, lead), toxic gases generated by combustion process following fires (aromatic hydrocarbons, PAHs, dioxins and furans, biphenyls, formaldehyde, metals and cyanides), substances emitted in case of chemical accidents (solvents, pesticides, toxic gases, caustics), drugs (methylamphetamine), riot control agents and self-defence spray, lead at firing ranges, and several materials and reagents used in forensic laboratory. The physical hazards are often caused by activities that induce biomechanical overload aid the onset of musculoskeletal disorders, the use of visual display terminals and work environments that may expose to heat stress and discomfort, high and low pressure, noise, vibrations, ionizing and non-ionizing radiation. The main biological risks are blood-borne diseases (viral hepatitis, AIDS), airborne diseases (eg, tuberculosis, meningitis, SARS, anthrax), MRSA, and vector-borne diseases. Many of these risk factors are unavoidable or are not predictable; so a proper risk assessment is very important, especially in case of emergencies, and also the necessary preventive measures, a careful analysis of alternative options for action and decision-making, implementation of security measures due to the provision of appropriate PPE and effective management of risk communication have great importance. Another important aspect is the education and training of staff, as in emergency situations should be able to take protective measures as quickly as possible.
[Mh] Termos MeSH primário: Doenças Transmissíveis/transmissão
Poluentes Ambientais/efeitos adversos
Substâncias Perigosas/efeitos adversos
Aplicação da Lei
Noxas/efeitos adversos
Doenças Profissionais/etiologia
Exposição Ocupacional
Fenômenos Físicos
Polícia
[Mh] Termos MeSH secundário: Patógenos Transmitidos pelo Sangue
Vazamento de Resíduos Químicos
Terminais de Computador
Armas de Fogo
Fogo
Seres Humanos
Itália/epidemiologia
Ruído/efeitos adversos
Doenças Profissionais/epidemiologia
Doenças Profissionais/prevenção & controle
Saúde do Trabalhador/legislação & jurisprudência
Lesões por Radiação/etiologia
Lesões por Radiação/prevenção & controle
Medição de Risco
Gestão da Segurança
Vibração/efeitos adversos
Violência
Tempo (Meteorologia)
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Environmental Pollutants); 0 (Hazardous Substances); 0 (Noxae)
[Em] Mês de entrada:1503
[Cu] Atualização por classe:150106
[Lr] Data última revisão:
150106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150107
[St] Status:MEDLINE



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