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Pesquisa : D27.888.569.100 [Categoria DeCS]
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[PMID]:27770707
[Au] Autor:Liu Y; Liu Y; Li H; Fu X; Guo H; Meng R; Lu W; Zhao M; Wang H
[Ad] Endereço:School of Environment, Tsinghua University, Beijing 10084, China; Key Laboratory for Solid Waste Management and Environment Safety (Tsinghua University), Ministry of Education of China, Tsinghua University, Beijing 100084, China.
[Ti] Título:Health risk impacts analysis of fugitive aromatic compounds emissions from the working face of a municipal solid waste landfill in China.
[So] Source:Environ Int;97:15-27, 2016 12.
[Is] ISSN:1873-6750
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Aromatic compounds (ACs) emitted from landfills have attracted a lot of attention of the public due to their adverse impacts on the environment and human health. This study assessed the health risk impacts of the fugitive ACs emitted from the working face of a municipal solid waste (MSW) landfill in China. The emission data was acquired by long-term in-situ samplings using a modified wind tunnel system. The uncertainty of aromatic emissions is determined by means of statistics and the emission factors were thus developed. Two scenarios, i.e. 'normal-case' and 'worst-case', were presented to evaluate the potential health risk in different weather conditions. For this typical large anaerobic landfill, toluene was the dominant species owing to its highest releasing rate (3.40±3.79g·m ·d ). Despite being of negligible non-carcinogenic risk, the ACs might bring carcinogenic risks to human in the nearby area. Ethylbenzene was the major health threat substance. The cumulative carcinogenic risk impact area is as far as ~1.5km at downwind direction for the normal-case scenario, and even nearly 4km for the worst-case scenario. Health risks of fugitive ACs emissions from active landfills should be concerned, especially for landfills which still receiving mixed MSW.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/análise
Resíduos Sólidos/análise
Compostos Orgânicos Voláteis/análise
[Mh] Termos MeSH secundário: Carcinógenos/análise
China
Seres Humanos
Eliminação de Resíduos
Risco
Tolueno/análise
Instalações de Eliminação de Resíduos
Vento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Carcinogens); 0 (Solid Waste); 0 (Volatile Organic Compounds); 3FPU23BG52 (Toluene)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180311
[Lr] Data última revisão:
180311
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE


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[PMID]:29431315
[Au] Autor:Shamilishvili GA; Abakumov EV; Gabov DN; Alekseev II
[Ti] Título:[Features of fractional composition of polycyclic aromatic hydrocarbons and multielement contamination of soils of urban territories and their hygienic characteristics (on the example of soils of functional zones of Saint-Petersburg)].
[So] Source:Gig Sanit;95(9):827-37, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:This study is devoted to the investigation of quantitative and qualitative composition and distribution of polycyclic aromatic hydrocarbons (PAHs) in urban soils on the example of recreational, residential and industrial areas of Saint-Petersburg (Russia). The evaluation of soil contamination levels with heavy metals and metalloids of the first and second classes of hazard is given as well. Total PAH content in soils of the studied area in most cases exceeds international soil quality guideline values (1 mg/kg), varying from 0.67 to 17.45 mg/kg. In most samples benzo[a] pyrene concentrations were found to be higher than MPC for this substance in soil. Calculated BaP-equivalents of PAHs indicate to the high carcinogenic risk for health, associated with soil contamination. Mean PAH concentrations in soil differ authentically between various types of functional zones and in the whole of the city. The significant positive correlation between soil organic content and PAH levels in soils was revealed in most samples. Calculated values of the total index of soil contamination (Zc) by heavy metals and metalloids were characterized by low values (47.28-121.14), that corresponds to the category of dangerous pollution (32 < Z < 128).
[Mh] Termos MeSH primário: Carcinógenos
Metais Pesados/análise
Hidrocarbonetos Aromáticos Policíclicos/análise
Saúde Pública
Poluentes do Solo
Solo/química
[Mh] Termos MeSH secundário: Carcinógenos/análise
Carcinógenos/toxicidade
Monitoramento Ambiental/métodos
Monitoramento Ambiental/estatística & dados numéricos
Poluição Ambiental/efeitos adversos
Poluição Ambiental/análise
Poluição Ambiental/prevenção & controle
Seres Humanos
Saúde da População/estatística & dados numéricos
Saúde Pública/métodos
Saúde Pública/normas
Federação Russa/epidemiologia
Poluentes do Solo/análise
Poluentes do Solo/química
Poluentes do Solo/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carcinogens); 0 (Metals, Heavy); 0 (Polycyclic Aromatic Hydrocarbons); 0 (Soil); 0 (Soil Pollutants)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE


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[PMID]:29264911
[Au] Autor:Mania M; Rebeniak M; Szynal T; Starska K; Wojciechowska-Mazurek M; Postupolski J
[Ad] Endereço:National Institute of Public Health-National Institute of Hygiene, Department of Food Safety, Warsaw, Poland
[Ti] Título:Exposure assessment of the population in Poland to the toxic effects of arsenic compounds present in rice and rice based products
[So] Source:Rocz Panstw Zakl Hig;68(4):339-346, 2017.
[Is] ISSN:0035-7715
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Background: Rice is a staple food for many people in the world and an important ingredient for production of food for infants and young children. According to European Food Safety Authority (EFSA), cereals, primarily rice and rice products, are an important source of human exposure to inorganic arsenic, which has been classified by the International Agency for Research on Cancer (IARC) as group I carcinogen. Arsenic is present in rice and rice products mainly as an inorganic form being more toxic than organic compounds Objectives: The aim of the study was to determine the total and inorganic arsenic content in rice, rice-based products including food for infants and young children available on the market in Poland and thus to estimate consumer exposure to inorganic arsenic from these groups of foodstuffs Materials and Methods: A total of 62 samples of rice and rice products from trade, including a group of rice products for infants and young children, were tested. Contents of total and inorganic arsenic were determined by using hydride generation atomic absorption spectrometry (HGAAS), after dry mineralization of samples and reduction of arsenic to arsenic hydride with sodium borohydride. To extract the inorganic arsenic forms, the samples were subjected to hydrolysis in concentrated HCl and then reduced in the presence of hydrobromic acid and hydrazine sulphate after which triple chloroform extractions and triple 1M HCl re-extractions were performed. Exposure of different groups of populations (adults and children), was estimated in relation to the Benchmark Dose Lower Confidence Limit (BMDL05) as set by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) that resulted in a 0.5% increase in lung cancer (3.0 µg/kg body weight (b.w.) per day) Results: Mean content of total and inorganic arsenic in investigated rice samples was 0.12 mg/kg (median: 0.09 mg/kg; 90th percentile 0.22 mg/kg) and 0.04 mg/kg (median: 0.03 mg/kg, 90th percentile 0.07 mg/kg). Brown rice was found to be more highly contaminated with both total and inorganic arsenic than white rice. Mean contamination of brown rice with total arsenic and inorganic arsenic was: 0.18 mg/kg (median: 0.12 mg/kg, 90th percentile: 0.32 mg/kg) and 0.05 mg/kg (median: 0.05 mg/kg, 90th percentile: 0.07 mg/kg). In turn for the white rice contamination was lower, mean total arsenic content: 0.10 mg/kg (median: 0.08 mg/kg, 90th percentile: 0.19 mg/kg) and mean inorganic arsenic: 0.03 mg/kg (median: 0.03 mg/kg, 90th percentile: 0.06 mg/kg). Contamination of rice-based products both total and inorganic arsenic was similar to those reported for rice, except rice wafers (mean: 0.24 mg/kg and 0.13 mg/kg). In the group of products for infants and young children obtained results were low ­ mean total arsenic content was 0.06 mg/kg and inorganic arsenic 0.02 mg/kg. The estimated average adult and children's exposure to inorganic arsenic with rice and rice products was less than 1% of the BMDL05. Intake of inorganic arsenic by 12-month-old infants with ricebased products intended for this group of population was at 6% BMDL05 Conclusions: Based on the obtained results, it was found that the content of total and inorganic arsenic in investigated samples of rice and rice products did not pose a health risk even though contamination levels in some individual samples were significant
[Mh] Termos MeSH primário: Arsenicais/análise
Carcinógenos/análise
Exposição Dietética/análise
Contaminação de Alimentos/análise
Oryza/química
[Mh] Termos MeSH secundário: Análise de Alimentos
Inocuidade dos Alimentos
Seres Humanos
Polônia
Medição de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenicals); 0 (Carcinogens)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


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[PMID]:29328669
[Au] Autor:Feng Y; Wang S; Wang H; Peng Y; Zheng J
[Ad] Endereço:Wuya College of Innovation, Shenyang Pharmaceutical University , Shenyang, Liaoning 110016, People's Republic of China.
[Ti] Título:Urinary Methyleugenol-deoxyadenosine Adduct as a Potential Biomarker of Methyleugenol Exposure in Rats.
[So] Source:J Agric Food Chem;66(5):1258-1263, 2018 Feb 07.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Methyleugenol (ME), a natural ingredient of several herbs and spices used in the human diet, is hepatocarcinogenic in rodents. Following metabolic activation to the reactive carbocation intermediate, ME can bind covalently to DNA, which is directly associated with its carcinogenicity. In this work, a non-invasive approach to determine ME exposure was established by monitoring the urinary N -(methylisoeugenol-3'-yl)-2'-deoxyadenosine (ME-dA) adduct. The developed method entails liquid-liquid extraction enrichment of urinary ME-dA, incorporation of deuterated ME-dA as an internal standard, and analysis by liquid chromatography coupled tandem mass spectrometry. Male rats (10-12 weeks, 180-200 g) were treated (p.o.) with ME, and ME-dA was excreted in urine in a dose- and time-dependent manner. The non-invasive approach enabled us to successfully determine exposure to ME-containing herbs and spices. These results suggest that ME-dA can potentially serve as an effective biomarker of ME exposure in rats. It is expected that the developed approach of detecting urinary ME-dA will facilitate the investigation of ME carcinogenesis.
[Mh] Termos MeSH primário: Biomarcadores/urina
Carcinógenos
Adutos de DNA/urina
Desoxiadenosinas/urina
Eugenol/análogos & derivados
[Mh] Termos MeSH secundário: Animais
Eugenol/análise
Eugenol/toxicidade
Eugenol/urina
Neoplasias Hepáticas/induzido quimicamente
Masculino
Ratos
Ratos Sprague-Dawley
Especificidade da Espécie
Especiarias/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Carcinogens); 0 (DNA Adducts); 0 (Deoxyadenosines); 29T9VA6R7M (methyleugenol); 3T8H1794QW (Eugenol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b05186


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[PMID]:29374702
[Au] Autor:Ferreira L; Vitorino R; Neuparth MJ; Rodrigues D; Gama A; Faustino-Rocha AI; Ferreira R; Oliveira PA
[Ad] Endereço:Organic Chemistry, Natural Products and Foodstuffs (QOPNA), Mass Spectrometry Center, University of Aveiro, Aveiro, Portugal.
[Ti] Título:Intense Pulsed Light: Friend or Foe? Molecular Evidence to Clarify Doubts.
[So] Source:Anticancer Res;38(2):779-786, 2018 02.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIM: Intense pulsed light (IPL) has been extensively applied in the field of dermatology and aesthetics; however, the long-term consequences of its use are poorly unknown, and to the best of our knowledge there is no study on the effect of IPL in neoplastic lesions. In order to better understand the molecular mechanisms underlying IPL application in the skin, we used an animal model of carcinogenesis obtained by chemical induction with 12-dimethylbenz(a)anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA). MATERIALS AND METHODS: Institute of Cancer Research (ICR) mice were administered DMBA and/or TPA and treated with IPL. Skin was evaluated by histopathology and 2DE-blot-MS/MS analysis. RESULTS: Our data evidenced an inflammatory response and a metabolic remodeling of skin towards a glycolytic phenotype after chronic exposure to IPL, which was accomplished by increased oxidative stress and susceptibility to apoptosis. These alterations induced by IPL were more notorious in the DMBA sensitized skin. Keratins and metabolic proteins seem to be the more susceptible to oxidative modifications that might result in loss of function, contributing for the histological changes observed in treated skin. CONCLUSION: Data highlight the deleterious impact of IPL on skin phenotype, which justifies the need for more experimental studies in order to increase our understanding of the IPL long-term safety.
[Mh] Termos MeSH primário: Terapia de Luz Pulsada Intensa/efeitos adversos
Neoplasias Cutâneas/etiologia
Pele/efeitos da radiação
[Mh] Termos MeSH secundário: 9,10-Dimetil-1,2-benzantraceno/administração & dosagem
Animais
Apoptose/efeitos dos fármacos
Apoptose/efeitos da radiação
Carcinógenos/administração & dosagem
Modelos Animais de Doenças
Feminino
Glicólise
Queratinas/metabolismo
Camundongos
Camundongos Endogâmicos ICR
Estresse Oxidativo/efeitos dos fármacos
Estresse Oxidativo/efeitos da radiação
Distribuição Aleatória
Pele/efeitos dos fármacos
Pele/metabolismo
Pele/patologia
Neoplasias Cutâneas/induzido quimicamente
Neoplasias Cutâneas/metabolismo
Neoplasias Cutâneas/patologia
Acetato de Tetradecanoilforbol/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carcinogens); 57-97-6 (9,10-Dimethyl-1,2-benzanthracene); 68238-35-7 (Keratins); NI40JAQ945 (Tetradecanoylphorbol Acetate)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180129
[St] Status:MEDLINE


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[PMID]:29179064
[Au] Autor:Loukotková L; VonTungeln LS; Vanlandingham M; da Costa GG
[Ad] Endereço:Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States. Electronic address: lucie.loukotkova@fda.hhs.gov.
[Ti] Título:A simple and highly sensitive UPLC-ESI-MS/MS method for the simultaneous quantification of nicotine, cotinine, and the tobacco-specific carcinogens N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in serum samples.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1072:229-234, 2018 Jan 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:According to the World Health Organization, the consumption of tobacco products is the single largest cause of preventable deaths in the world, exceeding the total aggregated number of deaths caused by diseases such as AIDS, tuberculosis, and malaria. An important element in the evaluation of the health risks associated with the consumption of tobacco products is the assessment of the internal exposure to the tobacco constituents responsible for their addictive (e.g. nicotine) and carcinogenic (e.g. N-nitrosamines such as NNN and NNK) properties. However, the assessment of the serum levels of these compounds is often challenging from an analytical standpoint, in particular when limited sample volumes are available and low detection limits are required. Currently available analytical methods often rely on complex multi-step sample preparation procedures, which are prone to low analyte recoveries and ex-vivo contamination due to the ubiquitous nature of these compounds as background contaminants. In order to circumvent these problems, we report a facile and highly sensitive method for the simultaneous quantification of nicotine, cotinine, NNN, and NNK in serum samples. The method relies on a simple "one pot" liquid-liquid extraction procedure and isotope dilution ultra-high pressure (UPLC) hydrophilic interaction liquid chromatography (HILIC) coupled with tandem mass spectrometry. The method requires only 10µL of serum and presents a limit of quantification of 0.02nmol (3000pg/mL) nicotine, 0.6pmol (100pg/mL) cotinine, 0.05pmol NNK (10pg/mL), and 0.06pmol NNN (10pg/mL), making it appropriate for pharmacokinetic evaluations.
[Mh] Termos MeSH primário: Carcinógenos/análise
Cotinina/sangue
Nicotina/sangue
Nitrosaminas/sangue
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão/métodos
Estabilidade de Medicamentos
Seres Humanos
Limite de Detecção
Modelos Lineares
Reprodutibilidade dos Testes
Espectrometria de Massas por Ionização por Electrospray/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carcinogens); 0 (Nitrosamines); 6M3C89ZY6R (Nicotine); 7S395EDO61 (4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone); K5161X06LL (Cotinine); X656TZ86DX (N'-nitrosonornicotine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:29305860
[Au] Autor:Zhong X; Lee HN; Surh YJ
[Ad] Endereço:Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
[Ti] Título:RvD1 inhibits TNFα-induced c-Myc expression in normal intestinal epithelial cells and destabilizes hyper-expressed c-Myc in colon cancer cells.
[So] Source:Biochem Biophys Res Commun;496(2):316-323, 2018 02 05.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Inflammatory bowel diseases, including ulcerative colitis and Crohn's disease, are persistent disorders that lead to development of colitis-associated cancer (CAC). Facilitated resolution of colitis has been addressed as a novel therapeutic strategy to control development of CAC. Resolvin D1 (RvD1) is an endogenous lipid mediator that is generated from docosahexaenoic acid during the resolution of inflammation. Although the pro-resolving effects of RvDs have been extensively investigated and well defined, the role for RvD1 in CAC remains largely unknown. In this study, we found that RvD1 inhibited the expression of c-Myc in normal colon cells stimulated with tumor necrosis factor-α (TNFα) and also in colon cancer cells. The suppression of TNFα-induced upregulation of c-Myc in normal cells was mediated through attenuation of NF-κB signaling. Notably, RvD1 destabilized the constitutively overexpressed c-Myc protein in HCT 116 human colon cancer cells by stimulating its ubiquitination and subsequent proteasomal degradation. Further, we revealed that RvD1 stimulated c-Myc degradation through direct interaction with the ALX/FPR2 receptor. This interaction resulted in inhibition of activation of extracellular signal-regulated kinase, thereby attenuating phosphorylation-dependent stabilization of c-Myc.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Antineoplásicos/farmacologia
Neoplasias do Colo/prevenção & controle
Proteínas de Ligação a DNA/genética
Ácidos Docosa-Hexaenoicos/farmacologia
Regulação Neoplásica da Expressão Gênica
Fatores de Transcrição/genética
Fator de Necrose Tumoral alfa/antagonistas & inibidores
[Mh] Termos MeSH secundário: Proteínas Adaptadoras de Transdução de Sinal/genética
Proteínas Adaptadoras de Transdução de Sinal/metabolismo
Animais
Azoximetano
Carcinógenos
Neoplasias do Colo/induzido quimicamente
Neoplasias do Colo/genética
Neoplasias do Colo/patologia
Proteínas de Ligação a DNA/antagonistas & inibidores
Proteínas de Ligação a DNA/metabolismo
Células HCT116
Seres Humanos
Camundongos
Camundongos Endogâmicos C57BL
NF-kappa B/genética
NF-kappa B/metabolismo
Fosforilação/efeitos dos fármacos
Complexo de Endopeptidases do Proteassoma/efeitos dos fármacos
Complexo de Endopeptidases do Proteassoma/metabolismo
Proteólise/efeitos dos fármacos
Receptores de Formil Peptídeo/genética
Receptores de Formil Peptídeo/metabolismo
Receptores de Lipoxinas/genética
Receptores de Lipoxinas/metabolismo
Transdução de Sinais
Fatores de Transcrição/antagonistas & inibidores
Fatores de Transcrição/metabolismo
Fator de Necrose Tumoral alfa/farmacologia
Ubiquitinação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Adaptor Proteins, Signal Transducing); 0 (Anti-Inflammatory Agents); 0 (Antineoplastic Agents); 0 (Carcinogens); 0 (DNA-Binding Proteins); 0 (FPR2 protein, human); 0 (HSH2D protein, human); 0 (MYCBP protein, human); 0 (NF-kappa B); 0 (Receptors, Formyl Peptide); 0 (Receptors, Lipoxin); 0 (Transcription Factors); 0 (Tumor Necrosis Factor-alpha); 0 (resolvin D1); 25167-62-8 (Docosahexaenoic Acids); EC 3.4.25.1 (Proteasome Endopeptidase Complex); MO0N1J0SEN (Azoxymethane)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180107
[St] Status:MEDLINE


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[PMID]:29277245
[Au] Autor:Tranchant R; Montagne F; Jaurand MC; Jean D
[Ad] Endereço:Inserm, UMR-1162, génomique fonctionnelle des tumeurs solides, équipe 1 « Génomique des tumeurs hépatiques et mésothéliales ¼, 75010 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Labex Immuno-oncology, 12, rue de l'école de Médecine, 75006 Paris, France; Université Paris Diderot, S
[Ti] Título:[Molecular heterogeneity of malignant pleural mesotheliomas].
[Ti] Título:Hétérogénéité moléculaire des mésothéliomes pleuraux malins..
[So] Source:Bull Cancer;105(1):35-45, 2018 Jan.
[Is] ISSN:1769-6917
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:Malignant pleural mesothelioma (MPM) is predominantly an occupational cancer, most often linked to asbestos exposure. Malignant pleural mesothelioma prognosis is poor with a short survival median, due to the aggressiveness of tumor cells and the weak efficiency of conventional anti-cancer therapies. Clinical, histological, and molecular data suggest tumor heterogeneity between patients as it was also shown for other cancer types. Consequently, there is an urgent need to develop new therapies that take into account this heterogeneity and the molecular characteristics of malignant pleural mesothelioma, in particular by identifying new anti-cancer drugs targeting the molecular specificities of each malignant pleural mesothelioma. Malignant pleural mesothelioma is characterized by numerous molecular alterations at the chromosomal, genetic and epigenetic levels. Molecular classification based on gene expression profile has firstly defined two tumor groups, C1 and C2, and more recently, four groups. By integrating genetic and transcriptomic analysis, a C2 tumor subgroup of the C2 group has been identified and characterized. In addition to tumor heterogeneity between patients, intra-tumor heterogeneity is supported by several evidences. Most therapeutic strategies that take into account the tumor molecular characteristics have focused on targeted therapies based on mutated genes. A more appropriate strategy would be to consider better-defined tumor groups on the basis of several molecular alterations types as it has been proposed for the C2 subgroup. A robust definition of homogeneous tumor groups sharing common molecular characteristics is necessary for the development of effective precision medicine for malignant pleural mesothelioma.
[Mh] Termos MeSH primário: Neoplasias Pulmonares/genética
Mesotelioma/genética
Neoplasias Pleurais/genética
[Mh] Termos MeSH secundário: Asbestos/toxicidade
Carcinógenos/toxicidade
Aberrações Cromossômicas
Epigênese Genética
Seres Humanos
Neoplasias Pulmonares/classificação
Neoplasias Pulmonares/etiologia
Neoplasias Pulmonares/terapia
Mesotelioma/classificação
Mesotelioma/etiologia
Mesotelioma/terapia
Neoplasias Pleurais/classificação
Neoplasias Pleurais/etiologia
Neoplasias Pleurais/terapia
Prognóstico
Transcrição Genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Carcinogens); 1332-21-4 (Asbestos)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171227
[St] Status:MEDLINE


  9 / 39950 MEDLINE  
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[PMID]:29260544
[Au] Autor:Tiong SH; Saparin N; Teh HF; Ng TLM; Md Zain MZB; Neoh BK; Md Noor A; Tan CP; Lai OM; Appleton DR
[Ad] Endereço:Sime Darby Technology Centre Sdn. Bhd. , 1st Floor, Block B, UPM-MTDC Technology Centre III, Lebuh Silikon, 43400 Serdang, Selangor, Malaysia.
[Ti] Título:Natural Organochlorines as Precursors of 3-Monochloropropanediol Esters in Vegetable Oils.
[So] Source:J Agric Food Chem;66(4):999-1007, 2018 Jan 31.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:During high-temperature refining of vegetable oils, 3-monochloropropanediol (3-MCPD) esters, possible carcinogens, are formed from acylglycerol in the presence of a chlorine source. To investigate organochlorine compounds in vegetable oils as possible precursors for 3-MCPD esters, we tested crude palm, soybean, rapeseed, sunflower, corn, coconut, and olive oils for the presence of organochlorine compounds. Having found them in all vegetable oils tested, we focused subsequent study on oil palm products. Analysis of the chlorine isotope mass pattern exhibited in high-resolution mass spectrometry enabled organochlorine compound identification in crude palm oils as constituents of wax esters, fatty acid, diacylglycerols, and sphingolipids, which are produced endogenously in oil palm mesocarp throughout ripening. Analysis of thermal decomposition and changes during refining suggested that these naturally present organochlorine compounds in palm oils and perhaps in other vegetable oils are precursors of 3-MCPD esters. Enrichment and dose-response showed a linear relationship to 3-MCPD ester formation and indicated that the sphingolipid-based organochlorine compounds are the most active precursors of 3-MCPD esters.
[Mh] Termos MeSH primário: Hidrocarbonetos Clorados/química
Óleos Vegetais/química
alfa-Cloridrina/química
[Mh] Termos MeSH secundário: Carcinógenos
Cloro/química
Ésteres/química
Contaminação de Alimentos
Manipulação de Alimentos
Glicerídeos/química
Óleo de Palmeira/química
alfa-Cloridrina/análise
alfa-Cloridrina/síntese química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carcinogens); 0 (Esters); 0 (Glycerides); 0 (Hydrocarbons, Chlorinated); 0 (Plant Oils); 4R7X1O2820 (Chlorine); 5QUO05548Z (Palm Oil); 96-24-2 (alpha-Chlorohydrin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04995


  10 / 39950 MEDLINE  
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[PMID]:29329665
[Au] Autor:Wang Y; Yu YX; Luan Y; An J; Yin DG; Zhang XY
[Ad] Endereço:School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China.
[Ti] Título:Bioactivation of 1-chloro-2-hydroxy-3-butene, an in vitro metabolite of 1,3-butadiene, by rat liver microsomes.
[So] Source:Chem Biol Interact;282:36-44, 2018 Feb 25.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:1-Chloro-2-hydroxy-3-butene (CHB) is an in vitro metabolite of 1,3-butadiene, a rodent/human carcinogen. To search for an approach detecting CHB in vivo, it is vital to obtain a full understanding of CHB metabolism. Previously, we demonstrated that CHB was bioactivated to 1-chloro-3-buten-2-one (CBO) by alcohol dehydrogenase. However, CHB metabolism by cytochrome P450s has not been reported. Thus, in the present study, CHB metabolism by rat liver microsomes was investigated. The results showed that CHB was converted to 1-chloro-3,4-epoxy-2-butanol (CEB) and CBO. 4-Methylpyrazole, a cytochrome P450 2E1-specific inhibitor, inhibited the formation of both CEB and CBO, while 1-benzylimidazole, a generic cytochrome P450 inhibitor, completely abolished the formation of CEB and CBO, suggesting that CHB metabolism was mediated by cytochrome P450s. Because the molecules have two chiral centers, CEB was detected as two stereoisomers, which were designated D-CEB and M-CEB, and were characterized as (2S,3R)-/(2R,3S)-CEB and (2R,3R)-/(2S,3S)-CEB, respectively. The amounts of M-CEB were more than those of D-CEB by 50-80%. The amounts of CEB and CBO increased linearly over time from 10 (or 20 min for CBO) to 50 min. CHB metabolism followed Michaelis-Menten kinetics; the K and V values were determined to be 6.4 ±â€¯0.7 mM and 0.10 ±â€¯0.01 nmol/min/mg protein for D-CEB, 4.2 ±â€¯0.5 mM and 0.16 ±â€¯0.01 nmol/min/mg protein for M-CEB, and 4.0 ±â€¯0.5 mM and 4.6 ±â€¯0.5 nmol/min/mg protein for CBO, respectively. Thus, CBO was the dominant product of CHB metabolism. Moreover, CEB was genotoxic at ≥ 50 µM as evaluated by the comet assay. Collectively, the data showed that CHB could be bioactivated to CEB and CBO by cytochrome P450s with CBO being the predominant product. Thus, the formation of CEB and CBO can be used as evidence of CHB production. The products may also play a role in toxicity of CHB.
[Mh] Termos MeSH primário: Butadienos/metabolismo
Butanóis/metabolismo
Microssomos Hepáticos/metabolismo
[Mh] Termos MeSH secundário: Animais
Carcinógenos/metabolismo
Ensaio Cometa/métodos
Sistema Enzimático do Citocromo P-450/metabolismo
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Butadienes); 0 (Butanols); 0 (Carcinogens); 671-56-7 (1-chloro-2-hydroxy-3-butene); 9035-51-2 (Cytochrome P-450 Enzyme System); JSD5FGP5VD (1,3-butadiene)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180114
[St] Status:MEDLINE



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