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[PMID]:29471760
[Au] Autor:Polvinen A; Laaksonen M; Rantala J; Hietaniemi M; Kannisto J; Kuivalainen S
[Ad] Endereço:Finnish Centre for Pensions, Helsinki, Finland.
[Ti] Título:Working while on a disability pension in Finland: Association of diagnosis and financial factors to employment.
[So] Source:Scand J Public Health;46(19_suppl):74-81, 2018 Feb.
[Is] ISSN:1651-1905
[Cp] País de publicação:Sweden
[La] Idioma:eng
[Ab] Resumo:AIMS: The aim of this study was to find out whether health and financial factors are associated with engagement in paid work during a disability pension. METHODS: The data included a 10 per cent sample of Finns aged 20-62 years who were drawing earnings-related full or partial disability pension in 2012 ( n = 14,418). Logistic regression analysis was used to estimate odds ratios for working while on a full or partial disability pension. RESULTS: Fourteen per cent of full disability pensioners and 76 per cent of partial disability pensioners were engaged in paid work. Full disability pensioners due to mental disorders were working less often than full disability pensioners due to other diseases. Partial disability pensioners due to cardiovascular diseases were working more than partial disability pensioners due to other diseases. More recent timing of disability pension was associated with working for both partial and full disability pensioners. Working while on disability pension was more common among those with higher education. Partial disability pensioners with average pension worked more often than those with high pension. CONCLUSIONS: By knowing the factors associated with working while on a disability pension, policies could be more efficiently allocated to encourage disability pensioners to take up work. One way would be to support disability pensioners with low education to work more. Another way to increase work among disability pensioners is to support the recently retired in working longer.
[Mh] Termos MeSH primário: Pessoas com Deficiência/estatística & dados numéricos
Emprego/estatística & dados numéricos
Pensões/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adulto
Diagnóstico
Feminino
Finlândia
Seres Humanos
Masculino
Meia-Idade
Fatores Socioeconômicos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180224
[St] Status:MEDLINE
[do] DOI:10.1177/1403494817738460


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[PMID]:27772534
[Au] Autor:Keshavarz M
[Ad] Endereço:Shiraz Neuroscience Research Center,Shiraz University of Medical Sciences,Shiraz,Iran.
[Ti] Título:Glial cells as key elements in the pathophysiology and treatment of bipolar disorder.
[So] Source:Acta Neuropsychiatr;29(3):140-152, 2017 Jun.
[Is] ISSN:1601-5215
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The exact pathophysiology of bipolar disorder (BD) is not yet fully understood, and there are many questions in this area which should be answered. This review aims to discuss the roles of glial cells in the pathophysiology of BD and their contribution to the mechanism of action of mood-stabilising drugs. METHODS: We critically reviewed the most recent advances regarding glial cell roles in the pathophysiology and treatment of BD and the neuroprotective and neurotrophic effects of these cells. RESULTS: Postmortem studies revealed a decrease in the glial cell number or density in the specific layers of prefrontal and anterior cingulate cortex in the patients with BD, whereas there was no difference in other brain regions, such as entorhinal cortex, amygdala and hippocampus. Astrocytes and oligodendrocytes were the most important glial types that were responsible for the glial reduction, but microglia activation rather than loss may be implicated in BD. The decreased number or density of glial cells may contribute to the pathological changes observed in neurons in the patients with BD. Alteration of specific neurotrophic factors such as glial cell line-derived neurotrophic factor and S100B may be an important feature of BD. Glial cells mediate the therapeutic effects of mood-stabilising agents in the treatment of BD. CONCLUSION: Recent studies provide important evidence on the impairment of glial cells in the pathophysiology and treatment of BD. However, future controlled studies are necessary to elucidate different aspects of glial cells contribution to BD, and the mechanism of action of mood-stabilising drugs.
[Mh] Termos MeSH primário: Tonsila do Cerebelo/citologia
Transtorno Bipolar/fisiopatologia
Hipocampo/citologia
Neuroglia/fisiologia
[Mh] Termos MeSH secundário: Tonsila do Cerebelo/metabolismo
Tonsila do Cerebelo/patologia
Astrócitos/metabolismo
Astrócitos/patologia
Transtorno Bipolar/tratamento farmacológico
Encéfalo/patologia
Encéfalo/fisiopatologia
Diagnóstico
Fator Neurotrófico Derivado de Linhagem de Célula Glial/metabolismo
Hipocampo/metabolismo
Hipocampo/patologia
Seres Humanos
Transtornos do Humor/tratamento farmacológico
Neuroglia/citologia
Neuroglia/metabolismo
Neurônios/metabolismo
Neurônios/patologia
Oligodendroglia/metabolismo
Oligodendroglia/patologia
Subunidade beta da Proteína Ligante de Cálcio S100/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (GDNF protein, human); 0 (Glial Cell Line-Derived Neurotrophic Factor); 0 (S100 Calcium Binding Protein beta Subunit); 0 (S100B protein, human)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1017/neu.2016.56


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[PMID]:29362789
[Au] Autor:Abbasi J
[Ti] Título:Shantanu Nundy, MD: The Human Diagnosis Project.
[So] Source:JAMA;319(4):329-331, 2018 Jan 23.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Aprendizado de Máquina
Consulta Remota
[Mh] Termos MeSH secundário: Diagnóstico
Educação Médica Continuada
Seres Humanos
Provedores de Redes de Segurança
Sociedades
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.13897


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[PMID]:29298148
[Au] Autor:Armstrong K; Ranganathan R; Fishman M
[Ad] Endereço:From the Department of Medicine, Massachusetts General Hospital, Boston (K.A., R.R., M.F.); and the Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge (M.F.) - both in Massachusetts.
[Ti] Título:Toward a Culture of Scientific Inquiry - The Role of Medical Teaching Services.
[So] Source:N Engl J Med;378(1):1-3, 2018 Jan 04.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Pesquisa Biomédica/educação
Internato e Residência
[Mh] Termos MeSH secundário: Centros Médicos Acadêmicos
Diagnóstico
Técnicas e Procedimentos Diagnósticos
Seres Humanos
Ensino
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE


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[PMID]:27773385
[Au] Autor:Mueller TM; Yates SD; Haroutunian V; Meador-Woodruff JH
[Ad] Endereço:Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: tonimueller@uabmc.edu.
[Ti] Título:Altered fucosyltransferase expression in the superior temporal gyrus of elderly patients with schizophrenia.
[So] Source:Schizophr Res;182:66-73, 2017 04.
[Is] ISSN:1573-2509
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Glycosylation is a post-translational modification that is an essential element in cell signaling and neurodevelopmental pathway regulation. Glycan attachment can influence the tertiary structure and molecular interactions of glycosylated substrates, adding an additional layer of regulatory complexity to functional mechanisms underlying central cell biological processes. One type of enzyme-mediated glycan attachment, fucosylation, can mediate glycoprotein and glycolipid cell surface expression, trafficking, secretion, and quality control to modulate a variety of inter- and intracellular signaling cascades. Building on prior reports of glycosylation abnormalities and evidence of dysregulated glycosylation enzyme expression in schizophrenia, we examined the protein expression of 5 key fucose-modifying enzymes: GDP-fucose:protein O-fucosyltransferase 1 (POFUT1), GDP-fucose:protein O-fucosyltransferase 2 (POFUT2), fucosyltransferase 8 (FUT8), fucosyltransferase 11 (FUT11), and plasma α-l-fucosidase (FUCA2) in postmortem superior temporal gyrus of schizophrenia (N=16) and comparison (N=14) subjects. We also used the fucose binding protein, Aleuria aurantia lectin (AAL), to assess α-1,6-fucosylated N-glycoprotein abundance in the same subjects. In schizophrenia, we found increased expression of POFUT2, a fucosyltransferase uniquely responsible for O-fucosylation of thrombospondin-like repeat domains that is involved in a non-canonical endoplasmic reticulum quality control pathway. We also found decreased expression of FUT8 in schizophrenia. Given that FUT8 is the only α-1,6-fucosyltransferase expressed in mammals, the concurrent decrease in AAL binding in schizophrenia, particularly evident for N-glycoproteins in the ~52-58kDa and ~60-70kDa molecular mass ranges, likely reflects a consequence of abnormal FUT8 expression in the disorder. Dysregulated FUT8 and POFUT2 expression could potentially explain a variety of molecular abnormalities in schizophrenia.
[Mh] Termos MeSH primário: Fucosiltransferases/metabolismo
Esquizofrenia/patologia
Lobo Temporal/enzimologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Análise de Variância
Animais
Antipsicóticos/farmacologia
Diagnóstico
Feminino
Regulação Enzimológica da Expressão Gênica/efeitos dos fármacos
Regulação Enzimológica da Expressão Gênica/fisiologia
Seres Humanos
Lectinas/farmacocinética
Masculino
Meia-Idade
Ratos
Ratos Sprague-Dawley
Esquizofrenia/metabolismo
Lobo Temporal/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Antipsychotic Agents); 0 (Lectins); 0 (lectin, Aleuria aurantia); EC 2.4.1.- (Fucosyltransferases); EC 2.4.1.221 (POFUT2 protein, human)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180113
[Lr] Data última revisão:
180113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  6 / 8257 MEDLINE  
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[PMID]:28469050
[Au] Autor:Olgers TJ; Dijkstra RS; Drost-de Klerck AM; Ter Maaten JC
[Ad] Endereço:Department of Internal Medicine, Emergency Department, University Medical Centre Groningen, UMCG, Groningen, the Netherlands.
[Ti] Título:The ABCDE primary assessment in the emergency department in medically ill patients: an observational pilot study.
[So] Source:Neth J Med;75(3):106-111, 2017 Apr.
[Is] ISSN:1872-9061
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Competency in the Airway Breathing Circulation Disability Exposure (ABCDE) approach is required for working in the emergency department. There is limited knowledge on how often and how completely the ABCDE approach is applied to medical patients. The objectives of this study were to assess the frequency with which the ABCDE approach was used in potentially unstable patients and to determine factors influencing the choice of whether or not to use the ABCDE approach. METHODS: This observational pilot study included 270 medical patients admitted to the emergency department and it was observed if and how completely the ABCDE approach was performed. We registered several factors possibly determining its use. RESULTS: Of the 270 patients included, 206 were identified as possibly unstable patients based on their triage code. The ABCDE approach was used in a minority of these patients (33%). When the ABCDE approach was used, it was done rapidly (generally within 10 minutes) and highly completely (> 80% of needed items). The choice not to use the ABCDE approach was frequently based on a first clinical impression and/or vital signs obtained during triage. The ABCDE approach was used more often with a higher triage code. CONCLUSIONS: We show that the emergency department staff are capable of performing the ABCDE approach rather completely (83%), but it was only used in the minority of potentially unstable patients. Important factors determining this choice were the vital signs on triage and a quick first impression. Whether this adequately selects patients in need for an ABCDE approach is not clear yet.
[Mh] Termos MeSH primário: Serviço Hospitalar de Emergência
Triagem/métodos
[Mh] Termos MeSH secundário: Diagnóstico
Seres Humanos
Projetos Piloto
Avaliação de Processos (Cuidados de Saúde)
Triagem/utilização
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180102
[Lr] Data última revisão:
180102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE


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[PMID]:29190726
[Au] Autor:Kuecuekbalaban P; Schmidt S; Beutel M; Weidner K; de Zwaan M; Braehler E; Muehlan H
[Ad] Endereço:Department Health and Prevention, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.
[Ti] Título:Socio-demographic, health-related, and individual correlates of diagnostic self-testing by lay people: Results from a representative survey in Germany.
[So] Source:PLoS One;12(11):e0188653, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: A broad range of self-tests (testing for e.g. HIV, cancer, hepatitis B/C) have become available and can be conducted by lay consumers without the help of a health professional. The aims of this study were to (a) investigate the prevalence of self-testing, (b) identify the most frequently used self-tests, and (c) explore the associations between socio-demographic, health-related and individual factors with self-testing. METHODS: A face-to-face plus paper-pencil cross-sectional survey was conducted. The sample consisted of 2.527 respondents who were representative of the German population in terms of the age, sex, and residence. Basic descriptive statistics and univariate logistic regression analyses were performed. RESULTS: 8.5% of the participants reported having used one or more self-tests in the past, totalling 363 self-tests, with a mean of 1.7 (min. = 1, max. = 6). The three self-tests most frequently indicated were for detecting diabetes, bowel cancer, and allergies. Self-testers were older (Nagelkerke R2 = .006, p < .01), had a higher BMI (Nagelkerke R2 = .013, p < .001) and displayed more physical and mental fatigue (Nagelkerke R2 = .031, p < .001) than non-testers. Self-testers also reported higher global life satisfaction values (Nagelkerke R2 = .008, p < .01) and a higher educational level (Nagelkerke R2 = .015, p < .01). CONCLUSIONS: Self-testing is fairly prevalent in Germany Given the current shortage of physicians in Germany, especially in rural areas, and recent studies on the use of self-medication, the topic of self-testing has a great practical and socio-political relevance. Future studies should investigate further predictors of self-testing (e.g. contextual, situational and individual factors) as well as the emotional consequences of testing as a layperson without the attendance of a health professional.
[Mh] Termos MeSH primário: Demografia
Diagnóstico
Autocuidado
Classe Social
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188653


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[PMID]:29183058
[Ti] Título:Diagnostic Problems: Guest Editorial.
[So] Source:JAMA;318(20):2050, 2017 11 28.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Patologia Clínica/história
Visitas com Preceptor/história
[Mh] Termos MeSH secundário: Diagnóstico
História do Século XX
Seres Humanos
[Pt] Tipo de publicação:CLASSICAL ARTICLE; HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171213
[Lr] Data última revisão:
171213
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.10496


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[PMID]:28980714
[Au] Autor:Schonhaut DR; McMillan CT; Spina S; Dickerson BC; Siderowf A; Devous MD; Tsai R; Winer J; Russell DS; Litvan I; Roberson ED; Seeley WW; Grinberg LT; Kramer JH; Miller BL; Pressman P; Nasrallah I; Baker SL; Gomperts SN; Johnson KA; Grossman M; Jagust WJ; Boxer AL; Rabinovici GD
[Ad] Endereço:Memory and Aging Center, University of California, San Francisco, San Francisco, CA.
[Ti] Título: F-flortaucipir tau positron emission tomography distinguishes established progressive supranuclear palsy from controls and Parkinson disease: A multicenter study.
[So] Source:Ann Neurol;82(4):622-634, 2017 Oct.
[Is] ISSN:1531-8249
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: F-flortaucipir (formerly F-AV1451 or F-T807) binds to neurofibrillary tangles in Alzheimer disease, but tissue studies assessing binding to tau aggregates in progressive supranuclear palsy (PSP) have yielded mixed results. We compared in vivo F-flortaucipir uptake in patients meeting clinical research criteria for PSP (n = 33) to normal controls (n = 46) and patients meeting criteria for Parkinson disease (PD; n = 26). METHODS: Participants underwent magnetic resonance imaging and positron emission tomography for amyloid-ß ( C-PiB or F-florbetapir) and tau ( F-flortaucipir). F-flortaucipir standardized uptake value ratios were calculated (t = 80-100 minutes, cerebellum gray matter reference). Voxelwise and region-of-interest group comparisons were performed in template space, with receiver operating characteristic curve analyses to assess single-subject discrimination. Qualitative comparisons with postmortem tau are reported in 1 patient who died 9 months after F-flortaucipir. RESULTS: Clinical PSP patients showed bilaterally elevated F-flortaucipir uptake in globus pallidus, putamen, subthalamic nucleus, midbrain, and dentate nucleus relative to controls and PD patients (voxelwise p < 0.05 family wise error corrected). Globus pallidus binding best distinguished PSP patients from controls and PD (area under the curve [AUC] = 0.872 vs controls, AUC = 0.893 vs PD). PSP clinical severity did not correlate with F-flortaucipir in any region. A patient with clinical PSP and pathological diagnosis of corticobasal degeneration had severe tau pathology in PSP-related brain structures with good correspondence between in vivo F-flortaucipir and postmortem tau neuropathology. INTERPRETATION: F-flortaucipir uptake was elevated in PSP versus controls and PD patients in a pattern consistent with the expected distribution of tau pathology. Ann Neurol 2017;82:622-634.
[Mh] Termos MeSH primário: Encéfalo/diagnóstico por imagem
Carbolinas/farmacocinética
Doença de Parkinson/diagnóstico por imagem
Tomografia por Emissão de Pósitrons
Paralisia Supranuclear Progressiva/diagnóstico por imagem
Proteínas tau/metabolismo
[Mh] Termos MeSH secundário: Idoso
Compostos de Anilina/farmacocinética
Mapeamento Encefálico
Estudos de Casos e Controles
Transtornos Cognitivos/diagnóstico
Transtornos Cognitivos/etiologia
Diagnóstico
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Testes Neuropsicológicos
Doença de Parkinson/complicações
Índice de Gravidade de Doença
Paralisia Supranuclear Progressiva/complicações
Tiazóis/farmacocinética
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole); 0 (7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole); 0 (Aniline Compounds); 0 (Carbolines); 0 (Thiazoles); 0 (tau Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171006
[St] Status:MEDLINE
[do] DOI:10.1002/ana.25060


  10 / 8257 MEDLINE  
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[PMID]:28919059
[Au] Autor:Josephs KA; Dickson DW; Tosakulwong N; Weigand SD; Murray ME; Petrucelli L; Liesinger AM; Senjem ML; Spychalla AJ; Knopman DS; Parisi JE; Petersen RC; Jack CR; Whitwell JL
[Ad] Endereço:Department of Neurology, Mayo Clinic, Rochester, MN, USA. Electronic address: josephs.keith@mayo.edu.
[Ti] Título:Rates of hippocampal atrophy and presence of post-mortem TDP-43 in patients with Alzheimer's disease: a longitudinal retrospective study.
[So] Source:Lancet Neurol;16(11):917-924, 2017 Nov.
[Is] ISSN:1474-4465
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Post-mortem studies have not identified an association between ß-amyloid or tau and rates of hippocampal atrophy in patients with Alzheimer's disease. TAR DNA binding protein 43 (TDP-43) is another protein linked to Alzheimer's disease. We aimed to investigate whether hippocampal TDP-43 is associated with increased rates of hippocampal atrophy. METHODS: In this longitudinal retrospective study, we analysed post-mortem brain tissue of all individuals with an Alzheimer's disease spectrum pathological diagnosis who had antemortem head MRI scans between Jan 1, 1999, and Dec 31, 2012, and who had been recruited into the Mayo Clinic Alzheimer's Disease Research Center, Mayo Clinic Alzheimer's Disease Patient Registry, or the Mayo Clinic Study of Aging. We did TDP-43 immunohistochemistry and classified individuals as follows: no TDP-43 in the amygdala or hippocampus; TDP-43 restricted to the amygdala; and TDP-43 spreading into the hippocampus. Each individual was also assigned a neurofibrillary tangle stage (B1-B3), relating to the likelihood of having Alzheimer's disease. We used longitudinal FreeSurfer software and tensor-based morphometry with symmetric normalisation to calculate hippocampal volume on all serial MRI scans and used linear mixed-effects regression models to estimate associations between TDP-43 and rate of hippocampal atrophy and to assess the trajectory of TDP-43-associated atrophy. FINDINGS: We identified 298 individuals meeting the inclusion criteria, with 816 usable MRI scans (spanning 1·0-11·2 years of the disease) available for analysis. 141 individuals showed no TDP-43 in the amygdala or hippocampus, 33 had TDP-43 restricted to the amygdala, and 124 had TDP-43 in the hippocampus. Among individuals with a high likelihood of having Alzheimer's disease (neurofibrillary tangle stage B3; n=205), those with hippocampal TDP-43 had faster rates of hippocampal atrophy (n=103, annual volume change -4·39%, 95% CI -4·82 to -3·95; p<0·0001) than did those with amygdala-only TDP-43 (n=20, -3·29%, -4·11 to -2·46; p<0·0001; difference -1·10%, 95% CI -2·02 to -0·19; p=0·02) and those without TDP-43 (n=82, -3·11%, -3·54 to -2·68; p<0·0001; difference -1·28%, -1·88 to -0·67; p<0·0001). Among individuals with an intermediate likelihood of having Alzheimer's disease (neurofibrillary tangle stage B2; n=56), those with hippocampal TDP-43 had faster rates of hippocampal atrophy (n=17, annual volume change -4·05%, 95% CI -5·09 to -2·99; p<0·0001) than did those with amygdala-only TDP-43 (n=6, -1·78%, -3·04 to -0·55; p=0·004; difference -2·27%, 95% CI -3·79 to -0·67; p=0·006) and those without TDP-43 (n=33, -1·63%, -2·43 to -0·83; p=0·0002; difference -2·43%, -3·66 to -1·18; p=0·0002). Hippocampal TDP-43 was not associated with the rate of hippocampal atrophy in individuals with a low likelihood of having Alzheimer's disease (neurofibrillary tangle stage B1; n=37). The trajectory analysis suggested that increased rates of TDP-43-associated hippocampal atrophy might occur at least 10 years before death. Results were similar for FreeSurfer and tensor-based morphometry. INTERPRETATION: TDP-43 should be considered as a potential factor related to increased rates of hippocampal atrophy in patients with Alzheimer's disease. Given the importance of hippocampal atrophy in Alzheimer's disease, it is imperative that techniques are developed for detection of TDP-43 in vivo. FUNDING: US National Institute on Aging (National Institutes of Health).
[Mh] Termos MeSH primário: Doença de Alzheimer/patologia
Proteínas de Ligação a DNA/metabolismo
Hipocampo/metabolismo
Hipocampo/patologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Doença de Alzheimer/diagnóstico por imagem
Doença de Alzheimer/genética
Tonsila do Cerebelo/metabolismo
Apolipoproteínas E/genética
Atrofia/diagnóstico por imagem
Atrofia/etiologia
Atrofia/patologia
Diagnóstico
Feminino
Hipocampo/diagnóstico por imagem
Seres Humanos
Estudos Longitudinais
Imagem por Ressonância Magnética
Masculino
Escalas de Graduação Psiquiátrica
Estudos Retrospectivos
Proteínas tau/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Apolipoproteins E); 0 (DNA-Binding Proteins); 0 (TDP-43 protein, human); 0 (tau Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE



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