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[PMID]:27773873
[Au] Autor:Rourk AR; Nolte FS; Litwin CM
[Ti] Título:Performance Characteristics of the Reverse Syphilis Screening Algorithm in a Population With a Moderately High Prevalence of Syphilis.
[So] Source:Am J Clin Pathol;146(5):572-577, 2016 Nov 01.
[Is] ISSN:1943-7722
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objectives: With the recent introduction of automated treponemal tests, a new reverse syphilis algorithm has been proposed and now used by many clinical laboratories. We analyzed the impact of instituting the reverse screening syphilis algorithm in a laboratory that serves a geographic area with a moderately high prevalence of syphilis infection. Methods: Serum samples sent for syphilis testing were tested using a treponemal enzyme immunoassay (EIA) as the screening assay. EIA reactive samples were tested by rapid plasma reagin (RPR) and titered to end point if reactive. RPR nonreactive samples were analyzed by the Treponema pallidum particle agglutination test (TP-PA). Pertinent medical records were reviewed for false-reactive screens and samples with evidence of past syphilis infection. Results: Among 10,060 patients tested, 502 (5%) were reactive on the initial EIA screen. The RPR was reactive in 150 (1.5%). TP-PA testing determined that 103 (1.0%) were falsely reactive on initial EIA screen. The reverse screening algorithm, however, identified 242 (2.4%) with evidence of latent, secondary, or past syphilis, 21 of whom had no or unknown prior treatment with antibiotics. Conclusions: Despite a 1.0% false-reactive rate, the reverse syphilis algorithm detected 21 patients with possible latent syphilis that may have gone undetected by traditional syphilis screening.
[Mh] Termos MeSH primário: Algoritmos
Anticorpos Antibacterianos/sangue
Antígenos de Bactérias/imunologia
Sífilis/diagnóstico
Treponema pallidum/imunologia
[Mh] Termos MeSH secundário: Reações Falso-Negativas
Seres Humanos
Técnicas Imunoenzimáticas
Imunoglobulina G/sangue
Prevalência
Sífilis/epidemiologia
Sífilis/microbiologia
Sorodiagnóstico da Sífilis
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Bacterial); 0 (Antigens, Bacterial); 0 (Immunoglobulin G)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1093/ajcp/aqw182


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[PMID]:29323852
[Au] Autor:Gurtsevitch VE; Senyuta NB; Lomaya MV; Ignatova AV; Dushenkina TE; Repkina IA; Pavlovskaya AI; Mudunov AM
[Ti] Título:Diagnostic value of the Epstein-Barr virus serological markers in patients with nasopharyngeal carcinoma in cases of undetectable primary tumor location.
[So] Source:Vopr Virusol;61(5):205-12, 2016.
[Is] ISSN:0507-4088
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:The goal of this work was to describe a method for diagnosis of the non-keratinizing nasopharyngeal carcinoma (nNPC) in cases of the undetectable primary tumor location. The method is based on evaluation of IgG and IgA antibody levels to the capsid (VCA) and early antigens (EA) of the Epstein-Barr virus (EBV). The diagnosis of nNPC is established by a so-called decision rule. The latter was created by mathematical processing of the method of multifactor analysis of the results of anti-EBV antibody testing of 72 patients with clinically and morphologically confirmed nNPC and 72 patients with other head and neck benign tumors (OHNT) not associated with EBV, which were tested as a control group. The diagnostic value of the decision rule which was tested in the group of 77 patients with confirmed nNPC and 231 patients of a control group was high. The numbers of false negative and false positive cases were equal to 5.2% (4/77) and 6.5% (17/231), respectively. Among 32 patients with undetectable primary tumors the decision rule was able to identify 11 cases of nNPC. This diagnosis later was confirmed by morphological and instrumental methods of study. Only in two cases, false negative result was obtained (2/32; 6.3%) indicating that the serological diagnostics of nNPC with the decision rule is highly specific but not exact. Thus, the data obtained allowed us to conclude that the serological testing of EBV specific antibody evaluated by the decision rule can be recommended as an important test supplementing the standard methods of pdNPC diagnostics including cases with undetected primary tumor location.
[Mh] Termos MeSH primário: Anticorpos Antivirais/sangue
Carcinoma/diagnóstico
Tomada de Decisão Clínica/métodos
Infecções por Vírus Epstein-Barr/diagnóstico
Neoplasias de Cabeça e Pescoço/diagnóstico
Neoplasias Nasofaríngeas/diagnóstico
Neoplasias/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Antígenos Virais/sangue
Antígenos Virais/imunologia
Biomarcadores/sangue
Proteínas do Capsídeo/sangue
Proteínas do Capsídeo/imunologia
Carcinoma/complicações
Carcinoma/imunologia
Carcinoma/virologia
Estudos de Casos e Controles
Infecções por Vírus Epstein-Barr/complicações
Infecções por Vírus Epstein-Barr/imunologia
Infecções por Vírus Epstein-Barr/virologia
Análise Fatorial
Reações Falso-Negativas
Reações Falso-Positivas
Feminino
Neoplasias de Cabeça e Pescoço/complicações
Neoplasias de Cabeça e Pescoço/imunologia
Neoplasias de Cabeça e Pescoço/virologia
Herpesvirus Humano 4/imunologia
Herpesvirus Humano 4/isolamento & purificação
Seres Humanos
Imunoglobulina A/sangue
Imunoglobulina G/sangue
Masculino
Neoplasias Nasofaríngeas/complicações
Neoplasias Nasofaríngeas/imunologia
Neoplasias Nasofaríngeas/virologia
Neoplasias/complicações
Neoplasias/imunologia
Neoplasias/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (Antigens, Viral); 0 (Biomarkers); 0 (Capsid Proteins); 0 (Immunoglobulin A); 0 (Immunoglobulin G)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE


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[PMID]:29320551
[Au] Autor:Navarro-Lozano A; Sánchez-Domene D; Rossa-Feres DC; Bosch J; Sawaya RJ
[Ad] Endereço:Departamento de Zoologia e Botânica. Universidade Estadual Paulista, São José do Rio Preto, São Paulo, Brazil.
[Ti] Título:Are oral deformities in tadpoles accurate indicators of anuran chytridiomycosis?
[So] Source:PLoS One;13(1):e0190955, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We evaluated the use of oral deformities as reliable proxies for determining Batrachochytrium dendrobatidis (Bd) infection in tadpoles of six anuran species of the Atlantic Forest in southeastern Brazil. We examined oral discs of 2156 tadpoles of six species of anurans collected in 2016: Aplastodiscus albosignatus, Boana albopunctata, Boana faber, Scinax hayii, Crossodactylus caramaschii, and Physalaemus cuvieri. Three oral deformities were recognized: lack of keratinization only in upper and/or lower jaw sheaths, lack of keratinization only in upper or lower tooth rows, and both deformities together. A subsample composed of all the individuals possessing oral deformities (N = 195) plus randomly selected individuals without oral deformities (N = 184) were tested for Bd via qPCR. Oral deformities were observed in all six species, but only five were infected with Bd. Since we found that dekeratinization of tooth rows was not associated with the presence of Bd in any of the studied species we used a new proxy (jaw sheaths dekeratinization with or without dekeratinization in tooth rows: JSD-proxy) for Bd detection. Our results showed a nonrandom relationship between Bd infection and JSD-proxy in three species of the family Hylidae. However, the use of JSD-proxy for Bd detection in these species resulted in up to 30.8% false positives and up to 29.3% false negatives. The use of the JSD-proxy in species for which no relationship was found reached 100% of false positives. We conclude that the use of oral dekeratinization as a generalized proxy for Bd detection in tadpoles should not be used as a single diagnosis technique.
[Mh] Termos MeSH primário: Anuros/microbiologia
Quitridiomicetos
Larva/microbiologia
Boca/patologia
Micoses/veterinária
[Mh] Termos MeSH secundário: Animais
Reações Falso-Negativas
Reações Falso-Positivas
Queratinas
Micoses/diagnóstico
Micoses/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
68238-35-7 (Keratins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190955


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[PMID]:29038002
[Au] Autor:Guichet E; Serrano L; Laurent C; Eymard-Duvernay S; Kuaban C; Vidal L; Delaporte E; Ngole EM; Ayouba A; Peeters M
[Ad] Endereço:UMI233-TransVIHMI/INSERM U1175, Institut de Recherche pour le Développement (IRD) and University of Montpellier, Montpellier, France.
[Ti] Título:Comparison of different nucleic acid preparation methods to improve specific HIV-1 RNA isolation for viral load testing on dried blood spots.
[So] Source:J Virol Methods;251:75-79, 2018 Jan.
[Is] ISSN:1879-0984
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In resource-limited countries (RLCs), WHO recommends HIV viral load (VL) on dried blood spots (DBS) for antiretroviral therapy (ART) monitoring of patients living in non-urban settings where plasma VL is not available. In order to reduce the impact of proviral DNA interference, leading to false positive results in samples with low plasma VL, we compared three different nucleic acid preparation methods with the NucliSens (Biomérieux) extraction, known for its high recovery of nucleic acids on DBS. Paired plasma-DBS samples (n=151) with predominantly low plasma VL (≤10,000 copies/ml; 74%) were used. At the threshold of 1,000 copies/ml on DBS, 51% and 10% were misclassified as false positives or false negatives, respectively with NucliSens, versus 41% and 20% with m2000sp (Abbott), described as more specific for RNA recovery. DNase treatments of nucleic acid extracts and free virus elution (FVE) protocol before nucleic acid extraction, reduced the proportion of false positives to 0% and 19%, but increased the proportion of false negatives to 40% and 73%. More efforts are thus still needed to improve performance of VL assays on DBS to monitor patients on ART in RLCs and allow timely switch to more costly second or third line ART regimes.
[Mh] Termos MeSH primário: Infecções por HIV/virologia
HIV-1/isolamento & purificação
Plasma/virologia
RNA Viral/análise
RNA Viral/isolamento & purificação
Manejo de Espécimes/métodos
Carga Viral/métodos
[Mh] Termos MeSH secundário: Reações Falso-Negativas
Reações Falso-Positivas
Seres Humanos
[Pt] Tipo de publicação:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171018
[St] Status:MEDLINE


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[PMID]:29236386
[Au] Autor:Galkin OY; Besarab AB; Lutsenko TN
[Ti] Título:Characteristics of enzyme-linked immunosorbent assay for detection of IgG antibodies specific to Сhlamydia trachomatis heat shock protein (HSP-60)
[So] Source:Ukr Biochem J;89(1):22-30, 2017 Jan-Feb.
[Is] ISSN:2409-4943
[Cp] País de publicação:Ukraine
[La] Idioma:eng
[Ab] Resumo:The goal of this work was to study sensitivity and specificity of the developed ELISA set for the identification of IgG antibodies against Chlamydia trachomatis HSP-60 (using biotinylated tyramine-based signal amplification system). The study was conducted using a panel of characterized sera, as well as two reference ELISA sets of similar purpose. According to the results of ELISA informative value parameters, the ELISA we have developed showed the highest specificity and sensitivity parameters (no false negative or false positive results were registered). In 4 out of 15 intralaboratory panel serum samples initially identified as negative, anti-HSP-60 IgG-antibodies test result in reference ELISA sets upon dilution changed from negative to positive. The nature of titration curves of false negative sera and commercial monoclonal antibodies А57-В9 against C. trachomatis HSP-60 after incubation for 24 h was indicative of the presence of anti-idiotypic antibodies in these samples. Upon sera dilution, idiotypic-anti-idiotypic complexes dissociated, which caused the change of test result. High informative value of the developed ELISA set for identification of IgG antibodies against C. trachomatis HSP-60 has been proven. Anti-idiotypic antibodies possessing C. trachomatis anti-HSP-60 activity and being one of the causes of false negative results of the relevant ELISA-based tests have been identified in blood sera of individuals infected with chlamydial genitourinary infection agents.
[Mh] Termos MeSH primário: Anticorpos Antibacterianos/análise
Antígenos de Bactérias/sangue
Chaperonina 60/sangue
Infecções por Chlamydia/diagnóstico
Chlamydia trachomatis/imunologia
Ensaio de Imunoadsorção Enzimática/métodos
Imunoglobulina G/análise
[Mh] Termos MeSH secundário: Anticorpos Anti-Idiotípicos/química
Anticorpos Antibacterianos/sangue
Anticorpos Antibacterianos/imunologia
Complexo Antígeno-Anticorpo/química
Antígenos de Bactérias/imunologia
Biotinilação
Chaperonina 60/imunologia
Infecções por Chlamydia/sangue
Infecções por Chlamydia/imunologia
Infecções por Chlamydia/microbiologia
Chlamydia trachomatis/química
Ensaio de Imunoadsorção Enzimática/normas
Reações Falso-Negativas
Seres Humanos
Soros Imunes/química
Imunoglobulina G/sangue
Imunoglobulina G/imunologia
Sensibilidade e Especificidade
Tiramina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Anti-Idiotypic); 0 (Antibodies, Bacterial); 0 (Antigen-Antibody Complex); 0 (Antigens, Bacterial); 0 (Chaperonin 60); 0 (Immune Sera); 0 (Immunoglobulin G); X8ZC7V0OX3 (Tyramine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.15407/ubj89.01.022


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[PMID]:28448390
[Au] Autor:Patino M; Kalin M; Griffin A; Minhajuddin A; Ding L; Williams T; Ishman S; Mahmoud M; Kurth CD; Szmuk P
[Ad] Endereço:From the *Department of Anesthesiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Departments of †Anesthesiology and ‡Clinical Sciences, UT Southwestern and Children's Medical Center, Dallas, Texas; §Division of Biostatistics and Epidemiology, Cincinnati, Ohio; ‖University of Texas Southwestern and Children's Medical Center, Dallas, Texas; ¶Division of Pediatric Otolaryngology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; #Department of Anesthesia and Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio; **Department of Anesthesiology, University of Texas Southwestern and Children's Medical Center, Dallas, Texas; and ††Dallas and Outcome Research Consortium, Cleveland, Ohio.
[Ti] Título:Comparison of Postoperative Respiratory Monitoring by Acoustic and Transthoracic Impedance Technologies in Pediatric Patients at Risk of Respiratory Depression.
[So] Source:Anesth Analg;124(6):1937-1942, 2017 06.
[Is] ISSN:1526-7598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In children, postoperative respiratory rate (RR) monitoring by transthoracic impedance (TI), capnography, and manual counting has limitations. The rainbow acoustic monitor (RAM) measures continuous RR noninvasively by a different methodology. Our primary aim was to compare the degree of agreement and accuracy of RR measurements as determined by RAM and TI to that of manual counting. Secondary aims include tolerance and analysis of alarm events. METHODS: Sixty-two children (2-16 years old) were admitted after tonsillectomy or receiving postoperative patient/parental-controlled analgesia. RR was measured at regular intervals by RAM, TI, and manual count. Each TI or RAM alarm resulted in a clinical evaluation to categorize as a true or false alarm. To assess accuracy and degree of agreement of RR measured by RAM or TI compared with manual counting, a Bland-Altman analysis was utilized showing the average difference and the limits of agreement. Sensitivity and specificity of RR alarms by TI and RAM are presented. RESULTS: Fifty-eight posttonsillectomy children and 4 patient/parental-controlled analgesia users aged 6.5 ± 3.4 years and weighting 35.3 ± 22.7 kg (body mass index percentile 76.6 ± 30.8) were included. The average monitoring time per patient was 15.9 ± 4.8 hours. RAM was tolerated 87% of the total monitoring time. The manual RR count was significantly different from TI (P = .007) with an average difference ± SD of 1.39 ± 10.6 but were not significantly different from RAM (P = .81) with an average difference ± SD of 0.17 ± 6.8. The proportion of time when RR measurements differed by ≥4 breaths was 22% by TI and was 11% by RAM. Overall, 276 alarms were detected (mean alarms/patient = 4.5). The mean number of alarms per patient were 1.58 ± 2.49 and 2.87 ± 4.32 for RAM and TI, respectively. The mean number of false alarms was 0.18 ± 0.71 for RAM and 1.00 ± 2.78 for TI. The RAM was found to have 46.6% sensitivity (95% confidence interval [CI], 0.29-0.64), 95.9% specificity (95% CI, 0.90-1.00), 88.9% positive predictive value (95% CI, 0.73-1.00), and 72.1% negative predictive value (95% CI, 0.61-0.84), whereas the TI monitor had 68.5% sensitivity (95% CI, 0.53-0.84), 72.0% specificity (95% CI, 0.60-0.84), 59.0% positive (95% CI, 0.44-0.74), and 79.5% negative predictive value (95% CI, 0.69-0.90). CONCLUSIONS: In children at risk of postoperative respiratory depression, RR assessment by RAM was not different to manual counting. RAM was well tolerated, had a lower incidence of false alarms, and had better specificity and positive predictive value than TI. Rigorous evaluation of the negative predictive value is essential to determine the role of postoperative respiratory monitoring with RAM.
[Mh] Termos MeSH primário: Acústica
Pulmão/fisiopatologia
Monitorização Fisiológica/métodos
Insuficiência Respiratória/diagnóstico
Taxa Respiratória
Tonsilectomia/efeitos adversos
[Mh] Termos MeSH secundário: Acústica/instrumentação
Adolescente
Criança
Pré-Escolar
Alarmes Clínicos
Impedância Elétrica
Reações Falso-Negativas
Reações Falso-Positivas
Feminino
Seres Humanos
Masculino
Monitorização Fisiológica/instrumentação
Ohio
Projetos Piloto
Pletismografia de Impedância
Valor Preditivo dos Testes
Estudos Prospectivos
Reprodutibilidade dos Testes
Insuficiência Respiratória/etiologia
Insuficiência Respiratória/fisiopatologia
Texas
Fatores de Tempo
Transdutores
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; MULTICENTER STUDY; OBSERVATIONAL STUDY; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1213/ANE.0000000000002062


  7 / 16950 MEDLINE  
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Texto completo SciELO Chile
[PMID]:29189860
[Au] Autor:Paillahueque G; Massardo T; Barberán M; Ocares G; Gallegos I; Toro L; Araya AV
[Ad] Endereço:Sección Medicina Nuclear, Hospital Clínico, Universidad de Chile, Santiago, Chile.
[Ti] Título:[False negative spect parathyroid scintigraphy with sestamibi in patients with primary hyperparathyroidism].
[Ti] Título:Análisis de falsos negativos en la cintigrafía SPECT de paratiroides con sestamibi en pacientes con hiperparatiroidismo primario sometidos a cirugía entre 2008-2015 en hospital universitario..
[So] Source:Rev Med Chil;145(8):1021-1027, 2017 Aug.
[Is] ISSN:0717-6163
[Cp] País de publicação:Chile
[La] Idioma:spa
[Ab] Resumo:BACKGROUND: 99mTc-sestamibi parathyroid SPECT scintigraphy is a useful tool in the pre-operative study of hyperparathyroidism. False negatives (FN) have been reported in 5.7-14% of the examinations. AIM: To characterize 99mTc-sestamibi FN in cases referred for primary hyperparathyroidism (PHP) to a university hospital. MATERIAL AND METHODS: Descriptive retrospective analysis. We included patients with PHP, studied with SPECT scintigraphy, operated at our center between 2008 and 2015. Clinical and surgical data were recorded; biopsies of the FN were blindly reviewed by one pathologist. RESULTS: One hundred twenty one scintigraphies fulfilled the inclusion criteria. Seven (5.8%) were negative and 114 positive. There was no difference in age, sex and PTH levels between FN and true positive scintigraphies. At surgery, one FN case had two hyperplasic glands and two cases had ectopic glands. Pathology reported adenoma in three cases, hyperplasia in three and carcinoma in one. The largest diameter of the lesion was lower in FN (1.3 and 2.1 cm respectively, p = 0.02) and the proportion of adenomas was higher in true positive cases (29% and 75% respectively; p < 0.01). The interval between scintigraphy and parathyroidectomy was greater in FN with a median of 92 days (range 20 days-3.2 years, p < 0.01). The percentage of oxyphilic cells observed was similar in both groups. CONCLUSIONS: FN parathyroid SPECT scintigraphies in PHP are uncommon. They corresponded to lesions under the equipment's resolution limit and resulted in longer time lags between scintigraphy and surgery.
[Mh] Termos MeSH primário: Hiperparatireoidismo Primário/diagnóstico por imagem
Glândulas Paratireoides/diagnóstico por imagem
Compostos Radiofarmacêuticos
Tecnécio Tc 99m Sestamibi
Tomografia Computadorizada de Emissão de Fóton Único/métodos
[Mh] Termos MeSH secundário: Adenoma/diagnóstico por imagem
Adenoma/patologia
Adulto
Idoso
Carcinoma/diagnóstico por imagem
Carcinoma/patologia
Reações Falso-Negativas
Feminino
Seres Humanos
Hiperparatireoidismo Primário/patologia
Hiperplasia/diagnóstico por imagem
Hiperplasia/patologia
Masculino
Meia-Idade
Glândulas Paratireoides/patologia
Neoplasias das Paratireoides/diagnóstico por imagem
Neoplasias das Paratireoides/patologia
Padrões de Referência
Valores de Referência
Estudos Retrospectivos
Estatísticas não Paramétricas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radiopharmaceuticals); 971Z4W1S09 (Technetium Tc 99m Sestamibi)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171218
[Lr] Data última revisão:
171218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE


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[PMID]:27775232
[Au] Autor:Pfeiffer ML; Ozgur OK; Myers JN; Peng A; Ning J; Zafereo ME; Thakar S; Thuro B; Prieto VG; Ross MI; Esmaeli B
[Ad] Endereço:Orbital Oncology and Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
[Ti] Título:Sentinel lymph node biopsy for ocular adnexal melanoma.
[So] Source:Acta Ophthalmol;95(4):e323-e328, 2017 Jun.
[Is] ISSN:1755-3768
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We sought to update our prior report of findings on sentinel lymph node biopsy (SLNB) and predictors of a positive SLN in patients with conjunctival or eyelid melanoma. METHODS: We reviewed the records of all patients with ocular adnexal melanoma who underwent SLNB at one institution during 2000-2015. We determined rates of positive and false-negative findings on SLNB, primary tumour features correlated with positive findings and rate of nodal recurrence (false-negative event) after negative findings. RESULTS: The study included 51 patients, 31 with conjunctival and 20 with eyelid melanoma. These patients include 30 patients who underwent SLNB during 2000-2008, described in our previous report, and 21 additional patients who underwent SLNB during 2008-2015. There were 30 women and 21 men with median age at SLNB of 62 years (range, 24-83). The nodal basins most commonly sampled were intraparotid (27 patients) and level II (14 patients). Ten patients had positive SLNB findings. Compared to tumours with negative findings, tumours with positive findings had greater median thickness (3.5 mm versus 2.2 mm, p = 0.04), greater median number of mitotic figures (6 versus 2, p = 0.03) and greater incidence of ulceration (80% versus 26%, p = 0.003). Perineural and vascular invasion were not significantly associated with positive findings. There were three false-negative events. Three patients (6%) had temporary marginal mandibular weakness which resolved spontaneously. CONCLUSION: SLNB in patients with ocular adnexal melanoma is safe and identifies nodal micrometastasis in approximately 20% of cases. Histologic features associated with a positive SLN included greater tumour thickness, greater number of mitotic figures and ulceration.
[Mh] Termos MeSH primário: Neoplasias da Túnica Conjuntiva/patologia
Neoplasias Palpebrais/patologia
Melanoma/secundário
Biópsia de Linfonodo Sentinela/métodos
Linfonodo Sentinela/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Reações Falso-Negativas
Feminino
Seres Humanos
Metástase Linfática
Masculino
Melanoma/diagnóstico
Meia-Idade
Valor Preditivo dos Testes
Prognóstico
Reprodutibilidade dos Testes
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171212
[Lr] Data última revisão:
171212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1111/aos.13252


  9 / 16950 MEDLINE  
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[PMID]:28873443
[Au] Autor:Lu Y; Wei JY; Yao DS; Pan ZM; Yao Y
[Ad] Endereço:Department of Gynecologic Oncology, Affiliated Tumor Hospital of Guang Xi Medical University, Nanning, People's Republic of China.
[Ti] Título:Application of carbon nanoparticles in laparoscopic sentinel lymph node detection in patients with early-stage cervical cancer.
[So] Source:PLoS One;12(9):e0183834, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To investigate the value of carbon nanoparticles in identifying sentinel lymph nodes in early-stage cervical cancer. METHODS: From January 2014 to January 2016, 40 patients with cervical cancer stage IA2-IIA, based on the International Federation of Gynecology and Obstetrics (FIGO) 2009 criteria, were included in this study. The normal cervix around the tumor was injected with a total of 1 mL of carbon nanoparticles (CNP)at 3 and 9 o'clock. All patients then underwent laparoscopic pelvic lymph node dissection and radical hysterectomy. The black-dyed sentinel lymph nodes were removed for routine pathological examination and immunohistochemical staining. RESULTS: Among the 40 patients, 38 patients had at least one sentinel lymph node (SLN). The detection rate was 95% (38/40). One hundred seventy-three SLNs were detected with an average of 3.9 SLNs per side. 25 positive lymph nodes, which included 21 positive SLNs, were detected in 8 (20%) patients. Sentinel lymph nodes were localized in the obturator (47.97%), internal lilac (13.87%), external lilac (26.59%), parametrial (1.16%), and common iliac (8.67%) regions. The sensitivity of the SLN detection was 100% (5/5), the accuracy was 97.37% (37/38), and the negative predictive value was 100. 0% and the false negative rate was 0%. CONCLUSIONS: Sentinel lymph nodes can be used to accurately predict the pathological state of pelvic lymph nodes in early cervical cancer. The detection rates and accuracy of sentinel lymph node were high. Carbon nanoparticles can be used to trace the sentinel lymph node in early cervical cancer.
[Mh] Termos MeSH primário: Nanotubos de Carbono/química
Biópsia de Linfonodo Sentinela
Linfonodo Sentinela/patologia
Neoplasias do Colo do Útero/diagnóstico
Neoplasias do Colo do Útero/cirurgia
[Mh] Termos MeSH secundário: Adulto
Reações Falso-Negativas
Feminino
Seres Humanos
Histerectomia
Imuno-Histoquímica
Laparoscopia
Excisão de Linfonodo
Metástase Linfática/patologia
Meia-Idade
Estadiamento de Neoplasias
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nanotubes, Carbon)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183834


  10 / 16950 MEDLINE  
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[PMID]:28858107
[Au] Autor:Xu MM; Yin S; Siddiqui AA; Salem RR; Schrope B; Sethi A; Poneros JM; Gress FG; Genkinger JM; Do C; Brooks CA; Chabot JA; Kluger MD; Kowalski T; Loren DE; Aslanian H; Farrell JJ; Gonda TA
[Ad] Endereço:aDivision of Digestive and Liver Diseases, Columbia University Medical Center, New York, NY bDivision of Gastroenterology and Hepatology, Thomas Jefferson University Medical Center, Philadelphia, PA cSection of Surgical Oncology, Division of Surgery, Yale University School of Medicine, New Haven, CT dPancreas Center, Division of Surgery eDepartment of Epidemiology, Mailman School of Public Health fHerbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY gSection of Digestive Disease, Yale University School of Medicine, New Haven, CT, USA.
[Ti] Título:Comparison of the diagnostic accuracy of three current guidelines for the evaluation of asymptomatic pancreatic cystic neoplasms.
[So] Source:Medicine (Baltimore);96(35):e7900, 2017 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Asymptomatic pancreatic cysts are a common clinical problem but only a minority of these cases progress to cancer. Our aim was to compare the accuracy to detect malignancy of the 2015 American Gastroenterological Association (AGA), the 2012 International Consensus/Fukuoka (Fukuoka guidelines [FG]), and the 2010 American College of Radiology (ACR) guidelines.We conducted a retrospective study at 3 referral centers for all patients who underwent resection for an asymptomatic pancreatic cyst between January 2008 and December 2013. We compared the accuracy of 3 guidelines in predicting high-grade dysplasia (HGD) or cancer in resected cysts. We performed logistic regression analyses to examine the association between cyst features and risk of HGD or cancer.A total of 269 patients met inclusion criteria. A total of 228 (84.8%) had a benign diagnosis or low-grade dysplasia on surgical pathology, and 41 patients (15.2%) had either HGD (n = 14) or invasive cancer (n = 27). Of the 41 patients with HGD or cancer on resection, only 3 patients would have met the AGA guideline's indications for resection based on the preoperative cyst characteristics, whereas 30/41 patients would have met the FG criteria for resection and 22/41 patients met the ACR criteria. The sensitivity, specificity, positive predictive value, negative predictive value of HGD, and/or cancer of the AGA guidelines were 7.3%, 88.2%, 10%, and 84.1%, compared to 73.2%, 45.6%, 19.5%, and 90.4% for the FG and 53.7%, 61%, 19.8%, and 88% for the ACR guidelines. In multivariable analysis, cyst size >3 cm, compared to ≤3 cm, (odds ratio [OR] = 2.08, 95% confidence interval [CI] = 1.11, 4.2) and each year increase in age (OR = 1.07, 95% CI = 1.03, 1.11) were positively associated with risk of HGD or cancer on resection.In patients with asymptomatic branch duct-intraductal papillary mucinous neoplasms or mucinous cystic neoplasms who underwent resection, the prevalence rate of HGD or cancer was 15.2%. Using the 2015 AGA criteria for resection would have missed 92.6% of patients with HGD or cancer. The more "inclusive" FG and ACR had a higher sensitivity for HGD or cancer but lower specificity. Given the current deficiencies of these guidelines, it will be important to determine the acceptable rate of false-positives in order to prevent a single true-positive.
[Mh] Termos MeSH primário: Cisto Pancreático/diagnóstico
Cisto Pancreático/patologia
Neoplasias Pancreáticas/diagnóstico
Neoplasias Pancreáticas/patologia
Guias de Prática Clínica como Assunto/normas
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Diagnóstico Diferencial
Reações Falso-Negativas
Feminino
Seres Humanos
Masculino
Meia-Idade
Cisto Pancreático/cirurgia
Neoplasias Pancreáticas/cirurgia
Estudos Retrospectivos
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007900



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