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[PMID]:27775390
[Au] Autor:Dai Z; Rosen IG; Wang C; Barnett N; Luczak SE
[Ad] Endereço:Department of Mathematics, University of Southern California, Los Angeles, CA 90089-2532, United States. email: zhengdai@usc.edu.
[Ti] Título:Using drinking data and pharmacokinetic modeling to calibrate transport model and blind deconvolution based data analysis software for transdermal alcohol biosensors.
[So] Source:Math Biosci Eng;13(5):911-934, 2016 10 01.
[Is] ISSN:1551-0018
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Alcohol researchers/clinicians have two ways to collect subject /patient field data, standard-drink self-report and the breath analyzer, neither of which is passive or accurate because active subject participation is required. Transdermal alcohol sensors have been developed to measure transdermal alcohol concentration (TAC), but they are used primarily as abstinence monitors because converting TAC into more meaningful blood/breath alcohol concentration (BAC/BrAC) is difficult. In this paper, BAC/BrAC is estimated from TAC by first calibrating forward distributed parameter-based convolution models for ethanol transport from the blood through the skin using patient-collected drinking data for a single drinking episode and a nonlinear pharmacokinetic metabolic absorption/elimination model to estimate BAC. TAC and estimated BAC are then used to fit the forward convolution filter. Nonlinear least squares with adjoint-based gradient computation are used to fit both models. Calibration results are compared with those obtained using BAC/BrAC from alcohol challenges and from standard, linear, metabolic absorption, and zero order kinetics-based elimination models, by considering peak BAC, time of peak, and area under the BAC curve. Our models (with population parameters) could be included in a smart phone app that makes it convenient for the subject/patient to enter drinking data for a single episode in the field.
[Mh] Termos MeSH primário: Consumo de Bebidas Alcoólicas
Técnicas Biossensoriais/métodos
Modelos Biológicos
Monitorização Ambulatorial/métodos
[Mh] Termos MeSH secundário: Técnicas Biossensoriais/instrumentação
Calibragem
Técnicas e Procedimentos Diagnósticos/instrumentação
Etanol/análise
Etanol/farmacocinética
Seres Humanos
Smartphone
Software
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
3K9958V90M (Ethanol)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.3934/mbe.2016023


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[PMID]:27779329
[Au] Autor:Aranda-Neri JC; Suárez-López L; DeMaria LM; Walker D
[Ad] Endereço:Education and Research in Health, Area General Hospital Number 5 Zacatepec Morelos, Mexican Social Security Institute Delegation Morelos, Mexico.
[Ti] Título:Indications for Cesarean Delivery in Mexico: Evaluation of Appropriate Use and Justification.
[So] Source:Birth;44(1):78-85, 2017 Mar.
[Is] ISSN:1523-536X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cesarean delivery is one of the most widely used surgical interventions in Latin America and in many cases it is performed with no clear medical indication. Our objective was to analyze the relationship between reported indications for a cesarean and support for that indication in the clinical record in four Mexican hospitals, during the 2006-2007 period. METHODS: The data are from 604 (37.1%) women from a total of 1,625 who were admitted to the hospital in labor, and who gave birth through cesarean. Multivariate logistical regression analysis was used to explore the association between indications for clinically justified or unjustified surgery and other clinical and sociodemographic variables. RESULTS: Supporting clinical information for indications of cesarean delivery were found in only 45 percent of the cases considered. The adjusted statistical analysis showed that the variables associated with an unjustified indication for cesarean were: not having had a prior birth (OR 1.84 [95% CI 1.16-2.89]), having a maximum cervical dilation of 4 centimeters or less at time of cesarean (OR 2.44 [95% CI 1.53-3.87]), and having received care in a private hospital (OR 6.11 [95% CI 1.90-19.57]). DISCUSSION: The indications for cesarean related to labor dynamics were those least supported. Not having had a prior birth poses the greatest risk of having a poorly supported indication for a cesarean delivery. It would be prudent to institute audits, and greater requirements for and surveillance of documentation for cesarean delivery indications.
[Mh] Termos MeSH primário: Cesárea/estatística & dados numéricos
Assistência à Saúde/normas
Obstetrícia/normas
[Mh] Termos MeSH secundário: Adulto
Bases de Dados Factuais
Técnicas e Procedimentos Diagnósticos
Feminino
Hospitais Privados/estatística & dados numéricos
Hospitais Públicos/estatística & dados numéricos
Seres Humanos
Modelos Logísticos
México/epidemiologia
Análise Multivariada
Gravidez
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; OBSERVATIONAL STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1111/birt.12259


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[PMID]:29362800
[Au] Autor:McInnes MDF; Moher D; Thombs BD; McGrath TA; Bossuyt PM; Clifford T; Cohen JF; Deeks JJ; Gatsonis C; Hooft L; Hunt HA; Hyde CJ; Korevaar DA; Leeflang MMG; Macaskill P; Reitsma JB; Rodin R; Rutjes AWS; Salameh JP; Stevens A; Takwoingi Y; Tonelli M; Weeks L; Whiting P; Willis BH; the PRISMA-DTA Group
[Ad] Endereço:Department of Radiology, University of Ottawa, Ottawa, Ontario, Canada.
[Ti] Título:Preferred Reporting Items for a Systematic Review and Meta-analysis of Diagnostic Test Accuracy Studies: The PRISMA-DTA Statement.
[So] Source:JAMA;319(4):388-396, 2018 01 23.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: Systematic reviews of diagnostic test accuracy synthesize data from primary diagnostic studies that have evaluated the accuracy of 1 or more index tests against a reference standard, provide estimates of test performance, allow comparisons of the accuracy of different tests, and facilitate the identification of sources of variability in test accuracy. Objective: To develop the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) diagnostic test accuracy guideline as a stand-alone extension of the PRISMA statement. Modifications to the PRISMA statement reflect the specific requirements for reporting of systematic reviews and meta-analyses of diagnostic test accuracy studies and the abstracts for these reviews. Design: Established standards from the Enhancing the Quality and Transparency of Health Research (EQUATOR) Network were followed for the development of the guideline. The original PRISMA statement was used as a framework on which to modify and add items. A group of 24 multidisciplinary experts used a systematic review of articles on existing reporting guidelines and methods, a 3-round Delphi process, a consensus meeting, pilot testing, and iterative refinement to develop the PRISMA diagnostic test accuracy guideline. The final version of the PRISMA diagnostic test accuracy guideline checklist was approved by the group. Findings: The systematic review (produced 64 items) and the Delphi process (provided feedback on 7 proposed items; 1 item was later split into 2 items) identified 71 potentially relevant items for consideration. The Delphi process reduced these to 60 items that were discussed at the consensus meeting. Following the meeting, pilot testing and iterative feedback were used to generate the 27-item PRISMA diagnostic test accuracy checklist. To reflect specific or optimal contemporary systematic review methods for diagnostic test accuracy, 8 of the 27 original PRISMA items were left unchanged, 17 were modified, 2 were added, and 2 were omitted. Conclusions and Relevance: The 27-item PRISMA diagnostic test accuracy checklist provides specific guidance for reporting of systematic reviews. The PRISMA diagnostic test accuracy guideline can facilitate the transparent reporting of reviews, and may assist in the evaluation of validity and applicability, enhance replicability of reviews, and make the results from systematic reviews of diagnostic test accuracy studies more useful.
[Mh] Termos MeSH primário: Lista de Checagem
Técnicas e Procedimentos Diagnósticos/normas
Guias como Assunto
Metanálise como Assunto
Literatura de Revisão como Assunto
[Mh] Termos MeSH secundário: Conferências de Consenso como Assunto
Técnica Delfos
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.19163


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Romero, Gustavo Adolfo Sierra
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[PMID]:27770602
[Au] Autor:Peixoto HM; Brito MA; Romero GA; Monteiro WM; de Lacerda MV; de Oliveira MR
[Ad] Endereço:Centre for Tropical Medicine, University of Brasília, Brasília, Federal District, Brazil.
[Ti] Título:Rapid diagnostic test for G6PD deficiency in Plasmodium vivax-infected men: a budget impact analysis based in Brazilian Amazon.
[So] Source:Trop Med Int Health;22(1):21-31, 2017 01.
[Is] ISSN:1365-3156
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The aim of this study was to estimate the incremental budget impact (IBI) of a rapid diagnostic test to detect G6PDd in male patients infected with Plasmodium vivax in the Brazilian Amazon, as compared with the routine protocol recommended in Brazil which does not include G6PDd testing. METHODS: The budget impact analysis was performed from the perspective of the Brazilian health system, in the Brazilian Amazon for the years 2013, 2014 and 2015. The analysis used a decision model to compare two scenarios: the first consisting of the routine recommended in Brazil which does not include prior diagnosis of dG6PD, and the second based on the use of RDT CareStart™ G6PD (CS-G6PD) in all male subjects diagnosed with vivax malaria. The expected implementation of the diagnostic test was 30% in the first year, 70% the second year and 100% in the third year. RESULTS: The analysis identified negative IBIs which were progressively smaller in the 3 years evaluated. The sensitivity analysis showed that the uncertainties associated with the analytical model did not significantly affect the results. CONCLUSION: A strategy based on the use of CS-G6PD would result in better use of public resources in the Brazilian Amazon.
[Mh] Termos MeSH primário: Técnicas e Procedimentos Diagnósticos/economia
Deficiência de Glucosefosfato Desidrogenase/diagnóstico
Deficiência de Glucosefosfato Desidrogenase/epidemiologia
Malária Vivax/epidemiologia
Programas de Rastreamento/economia
[Mh] Termos MeSH secundário: Antimaláricos/uso terapêutico
Brasil/epidemiologia
Orçamentos
Técnicas de Apoio para a Decisão
Seres Humanos
Malária Vivax/tratamento farmacológico
Masculino
Modelos Econométricos
Primaquina/uso terapêutico
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antimalarials); MVR3634GX1 (Primaquine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE
[do] DOI:10.1111/tmi.12800


  5 / 2686 MEDLINE  
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[PMID]:29298148
[Au] Autor:Armstrong K; Ranganathan R; Fishman M
[Ad] Endereço:From the Department of Medicine, Massachusetts General Hospital, Boston (K.A., R.R., M.F.); and the Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge (M.F.) - both in Massachusetts.
[Ti] Título:Toward a Culture of Scientific Inquiry - The Role of Medical Teaching Services.
[So] Source:N Engl J Med;378(1):1-3, 2018 Jan 04.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Pesquisa Biomédica/educação
Internato e Residência
[Mh] Termos MeSH secundário: Centros Médicos Acadêmicos
Diagnóstico
Técnicas e Procedimentos Diagnósticos
Seres Humanos
Ensino
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE


  6 / 2686 MEDLINE  
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[PMID]:28742293
[Ti] Título:Saliva May Have Disease-Detecting 'Fingerprints'.
[So] Source:J Calif Dent Assoc;44(9):544, 2016 Sep.
[Is] ISSN:1043-2256
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Técnicas e Procedimentos Diagnósticos
Saliva/química
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:NEWS
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180102
[Lr] Data última revisão:
180102
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE


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[PMID]:28467215
[Au] Autor:Williams BJ; DaCosta P; Goacher E; Treanor D
[Ti] Título:A Systematic Analysis of Discordant Diagnoses in Digital Pathology Compared With Light Microscopy.
[So] Source:Arch Pathol Lab Med;141(12):1712-1718, 2017 Dec.
[Is] ISSN:1543-2165
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CONTEXT: - Relatively little is known about the significance and potential impact of glass-digital discordances, and this is likely to be of importance when considering digital pathology adoption. OBJECTIVE: - To apply evidence-based medicine to collect and analyze reported instances of glass-digital discordance from the whole slide imaging validation literature. DESIGN: - We used our prior systematic review protocol to identify studies assessing the concordance of light microscopy and whole slide imaging between 1999 and 2015. Data were extracted and analyzed by a team of histopathologists to classify the type, significance, and potential root cause of discordances. RESULTS: - Twenty-three studies were included, yielding 8069 instances of a glass diagnosis being compared with a digital diagnosis. From these 8069 comparisons, 335 instances of discordance (4%) were reported, in which glass was the preferred diagnostic medium in 286 (85%), and digital in 44 (13%), with no consensus in 5 (2%). Twenty-eight discordances had the potential to cause moderate/severe patient harm. Of these, glass was the preferred diagnostic medium for 26 (93%). Of the 335 discordances, 109 (32%) involved the diagnosis or grading of dysplasia. For these cases, glass was the preferred diagnostic medium in 101 cases (93%), suggesting that diagnosis and grading of dysplasia may be a potential pitfall of digital diagnosis. In 32 of 335 cases (10%), discordance on digital was attributed to the inability to find a small diagnostic/prognostic object. CONCLUSIONS: - Systematic analysis of concordance studies reveals specific areas that may be problematic on whole slide imaging. It is important that pathologists are aware of these areas to ensure patient safety.
[Mh] Termos MeSH primário: Técnicas e Procedimentos Diagnósticos
Microscopia/métodos
[Mh] Termos MeSH secundário: Diagnóstico por Computador/métodos
Erros de Diagnóstico
Medicina Baseada em Evidências/métodos
Seres Humanos
Interpretação de Imagem Assistida por Computador/métodos
Patologia Clínica/métodos
Sociedades Médicas
Reino Unido
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171212
[Lr] Data última revisão:
171212
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.5858/arpa.2016-0494-OA


  8 / 2686 MEDLINE  
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[PMID]:29073145
[Au] Autor:Fitzpatrick C; Asiedu K; Sands A; Gonzalez Pena T; Marks M; Mitja O; Meheus F; Van der Stuyft P
[Ad] Endereço:Department of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland.
[Ti] Título:The cost and cost-effectiveness of rapid testing strategies for yaws diagnosis and surveillance.
[So] Source:PLoS Negl Trop Dis;11(10):e0005985, 2017 Oct.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Yaws is a non-venereal treponemal infection caused by Treponema pallidum subspecies pertenue. The disease is targeted by WHO for eradication by 2020. Rapid diagnostic tests (RDTs) are envisaged for confirmation of clinical cases during treatment campaigns and for certification of the interruption of transmission. Yaws testing requires both treponemal (trep) and non-treponemal (non-trep) assays for diagnosis of current infection. We evaluate a sequential testing strategy (using a treponemal RDT before a trep/non-trep RDT) in terms of cost and cost-effectiveness, relative to a single-assay combined testing strategy (using the trep/non-trep RDT alone), for two use cases: individual diagnosis and community surveillance. METHODS: We use cohort decision analysis to examine the diagnostic and cost outcomes. We estimate cost and cost-effectiveness of the alternative testing strategies at different levels of prevalence of past/current infection and current infection under each use case. We take the perspective of the global yaws eradication programme. We calculate the total number of correct diagnoses for each strategy over a range of plausible prevalences. We employ probabilistic sensitivity analysis (PSA) to account for uncertainty and report 95% intervals. RESULTS: At current prices of the treponemal and trep/non-trep RDTs, the sequential strategy is cost-saving for individual diagnosis at prevalence of past/current infection less than 85% (81-90); it is cost-saving for surveillance at less than 100%. The threshold price of the trep/non-trep RDT (below which the sequential strategy would no longer be cost-saving) is US$ 1.08 (1.02-1.14) for individual diagnosis at high prevalence of past/current infection (51%) and US$ 0.54 (0.52-0.56) for community surveillance at low prevalence (15%). DISCUSSION: We find that the sequential strategy is cost-saving for both diagnosis and surveillance in most relevant settings. In the absence of evidence assessing relative performance (sensitivity and specificity), cost-effectiveness is uncertain. However, the conditions under which the combined test only strategy might be more cost-effective than the sequential strategy are limited. A cheaper trep/non-trep RDT is needed, costing no more than US$ 0.50-1.00, depending on the use case. Our results will help enhance the cost-effectiveness of yaws programmes in the 13 countries known to be currently endemic. It will also inform efforts in the much larger group of 71 countries with a history of yaws, many of which will have to undertake surveillance to confirm the interruption of transmission.
[Mh] Termos MeSH primário: Técnicas e Procedimentos Diagnósticos/economia
Bouba/diagnóstico
Bouba/economia
[Mh] Termos MeSH secundário: Estudos de Coortes
Análise Custo-Benefício
Técnicas e Procedimentos Diagnósticos/instrumentação
Técnicas e Procedimentos Diagnósticos/estatística & dados numéricos
Erradicação de Doenças/economia
Monitoramento Epidemiológico
Seres Humanos
Prevalência
Sensibilidade e Especificidade
Treponema pallidum/isolamento & purificação
Bouba/epidemiologia
Bouba/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171027
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005985


  9 / 2686 MEDLINE  
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[PMID]:28964454
[Au] Autor:Watts RD; Li IW; Geelhoed EA; Sanfilippo FM; St John A
[Ad] Endereço:School of Population and Global Health, The University of Western Australia, Perth, WA, Australia.
[Ti] Título:Economic Evaluations of Pathology Tests, 2010-2015: A Scoping Review.
[So] Source:Value Health;20(8):1210-1215, 2017 Sep.
[Is] ISSN:1524-4733
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Concerns about pathology testing such as the value provided by new tests and the potential for inappropriate utilization have led to a greater need to assess costs and benefits. Economic evaluations are a formal method of analyzing costs and benefits, yet for pathology tests, questions remain about the scope and quality of the economic evidence. OBJECTIVE: To describe the extent and quality of published evidence provided by economic evaluations of pathology tests from 2010 to 2015. METHODS: Economic evaluations relating to pathology tests from 2010 to 2015 were reviewed. Eight databases were searched for published studies, and details recorded for the country, clinical focus, type of testing, and consideration of sensitivity, specificity, and false test results. The reporting quality of studies was assessed using the Consolidated Health Economic Evaluation Reporting Standards checklist and cost-effectiveness ratios were analyzed for publication bias. RESULTS: We found 356 economic evaluations of pathology tests, most of which regarded developed countries. The most common economic evaluations were cost-utility analyses and the most common clinical focus was infectious diseases. More than half of the studies considered sensitivity and specificity, but few studies considered the impact of false test results. The average Consolidated Health Economic Evaluation Reporting Standards checklist score was 17 out of 24. Cost-utility ratios were commonly less than $10,000/quality-adjusted life-year or more than $200,000/quality-adjusted life-year. CONCLUSIONS: The number of economic evaluations of pathology tests has increased in recent years, but the rate of increase has plateaued. Furthermore, the quality of studies in the past 5 years was highly variable, and there is some question of publication bias in reporting cost-effectiveness ratios.
[Mh] Termos MeSH primário: Técnicas e Procedimentos Diagnósticos/economia
Patologia Clínica/métodos
Anos de Vida Ajustados por Qualidade de Vida
[Mh] Termos MeSH secundário: Análise Custo-Benefício
Reações Falso-Positivas
Seres Humanos
Patologia Clínica/economia
Projetos de Pesquisa
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171002
[St] Status:MEDLINE


  10 / 2686 MEDLINE  
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[PMID]:28880900
[Au] Autor:Maulucci G; Cordelli E; Rizzi A; De Leva F; Papi M; Ciasca G; Samengo D; Pani G; Pitocco D; Soda P; Ghirlanda G; Iannello G; De Spirito M
[Ad] Endereço:Istituto di Fisica, Università Cattolica del Sacro Cuore, Rome, Italy.
[Ti] Título:Phase separation of the plasma membrane in human red blood cells as a potential tool for diagnosis and progression monitoring of type 1 diabetes mellitus.
[So] Source:PLoS One;12(9):e0184109, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Glycosylation, oxidation and other post-translational modifications of membrane and transmembrane proteins can alter lipid density, packing and interactions, and are considered an important factor that affects fluidity variation in membranes. Red blood cells (RBC) membrane physical state, showing pronounced alterations in Type 1 diabetes mellitus (T1DM), could be the ideal candidate for monitoring the disease progression and the effects of therapies. On these grounds, the measurement of RBC membrane fluidity alterations can furnish a more sensitive index in T1DM diagnosis and disease progression than Glycosylated hemoglobin (HbA1c), which reflects only the information related to glycosylation processes. Here, through a functional two-photon microscopy approach we retrieved fluidity maps at submicrometric scale in RBC of T1DM patients with and without complications, detecting an altered membrane equilibrium. We found that a phase separation between fluid and rigid domains occurs, triggered by systemic effects on membranes fluidity of glycation and oxidation. The phase separation patterns are different among healthy, T1DM and T1DM with complications patients. Blood cholesterol and LDL content are positively correlated with the extent of the phase separation patterns. To quantify this extent a machine learning approach is employed to develop a Decision-Support-System (DSS) able to recognize different fluidity patterns in RBC. Preliminary analysis shows significant differences(p<0.001) among healthy, T1DM and T1DM with complications patients. The development of an assay based on Phase separation of the plasma membrane of the Red Blood cells is a potential tool for diagnosis and progression monitoring of type 1 diabetes mellitus, and could allow customization and the selection of medical treatments in T1DM in clinical settings, and enable the early detection of complications.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 1/sangue
Diabetes Mellitus Tipo 1/diagnóstico
Técnicas e Procedimentos Diagnósticos
Progressão da Doença
Membrana Eritrocítica/metabolismo
[Mh] Termos MeSH secundário: Colesterol/metabolismo
Sistemas de Apoio a Decisões Clínicas
Membrana Eritrocítica/efeitos dos fármacos
Hemoglobina A Glicada/metabolismo
Glicosilação/efeitos dos fármacos
Seres Humanos
Insulina/administração & dosagem
Insulina/farmacologia
Lipoproteínas LDL/metabolismo
Fluidez de Membrana/efeitos dos fármacos
Microdomínios da Membrana/efeitos dos fármacos
Microdomínios da Membrana/metabolismo
Oxirredução/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycated Hemoglobin A); 0 (Insulin); 0 (Lipoproteins, LDL); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170908
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184109



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde