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[PMID]:29351567
[Au] Autor:Ghandhi SA; Turner HC; Shuryak I; Dugan GO; Bourland JD; Olson JD; Tooze JA; Morton SR; Batinic-Haberle I; Cline JM; Amundson SA
[Ad] Endereço:Center for Radiological Research, Columbia University Medical Center, New York, New York, United States of America.
[Ti] Título:Whole thorax irradiation of non-human primates induces persistent nuclear damage and gene expression changes in peripheral blood cells.
[So] Source:PLoS One;13(1):e0191402, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We investigated the cytogenetic and gene expression responses of peripheral blood cells of non-human primates (NHP, Macaca mulatta) that were whole-thorax irradiated with a single dose of 10 Gy. In this model, partial irradiation of NHPs in the thoracic region (Whole Thorax Lung Irradiation, WTLI) allows the study of late radiation-induced lung injury, while avoiding acute radiation syndromes related to hematopoietic and gastrointestinal injury. A transient drop in circulating lymphocytes and platelets was seen by 9 days, followed by elevations in respiratory rate, circulating neutrophils, lymphocytes, and monocytes at 60-100 days, corresponding to computed tomography (CT) and histologic evidence of pneumonitis, and elective euthanasia of four animals. To evaluate long-term DNA damage in NHP peripheral blood lymphocytes after 10 Gy WTLI, we used the cytokinesis-block micronucleus (CBMN) assay to measure chromosomal aberrations as post-mitotic micronuclei in blood samples collected up to 8 months after irradiation. Regression analysis showed significant induction of micronuclei in NHP blood cells that persisted with a gradual decline over the 8-month study period, suggesting long-term DNA damage in blood lymphocytes after WTLI. We also report transcriptomic changes in blood up to 30 days after WTLI. We isolated total RNA from peripheral blood at 3 days before and then at 2, 5 and 30 days after irradiation. We identified 1187 transcripts that were significantly changed across the 30-day time course. From changes in gene expression, we identified biological processes related to immune responses, which persisted across the 30-day study. Response to oxygen-containing compounds and bacteria were implicated by gene-expression changes at the earliest day 2 and latest, day 30 time-points. Gene expression changes suggest a persistent altered state of the immune system, specifically response to infection, for at least a month after WTLI.
[Mh] Termos MeSH primário: Células Sanguíneas/metabolismo
Células Sanguíneas/efeitos da radiação
Dano ao DNA
Expressão Gênica/efeitos da radiação
[Mh] Termos MeSH secundário: Animais
Contagem de Células Sanguíneas
Aberrações Cromossômicas
Relação Dose-Resposta à Radiação
Ontologia Genética
Seres Humanos
Lesão Pulmonar/sangue
Lesão Pulmonar/etiologia
Lesão Pulmonar/genética
Macaca mulatta/sangue
Macaca mulatta/genética
Masculino
Testes para Micronúcleos
Lesões Experimentais por Radiação/sangue
Lesões Experimentais por Radiação/genética
Tórax/efeitos da radiação
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180120
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191402


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[PMID]:28459903
[Au] Autor:Vukkadala N; Auerbach A
[Ad] Endereço:School of Medicine, University of California San Francisco School of Medicine, San Francisco, CA.
[Ti] Título:Clinical Utility of Routine CBC Testing in Patients with Community-Acquired Pneumonia.
[So] Source:J Hosp Med;12(5):336-338, 2017 May.
[Is] ISSN:1553-5606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The goal of this study was to identify situations in which routine complete blood count (CBC) testing could be avoided in patients with community-acquired pneumonia (CAP). This was a retrospective study of 50 patients with CAP. Vital signs, lab results, assessment and plan data, and computerized provider order entry logs were collected to determine if a lab result or clinical finding changed clinical management. Clinical stability was defined based on Patient Outcomes Research Team study criteria. There were 94 CBCs obtained after admission, of which only 6 were associated with management changes. Only two of these instances involved management changes related to patients' pneumonia, while the other cases represented chronic illnesses. Among all patients, the positive likelihood ratio of a post-admission CBC predicting a change in clinical management was low (1.12 [95% confidence interval, 0.86-1.44]). Low utility of CBC testing after admission may represent an opportunity to improvethe value of care in CAP patients. Journal of Hospital Medicine 2017;12:336-338.
[Mh] Termos MeSH primário: Contagem de Células Sanguíneas/métodos
Contagem de Células Sanguíneas/utilização
Tomada de Decisão Clínica/métodos
Pneumonia/sangue
Pneumonia/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Infecções Comunitárias Adquiridas/sangue
Infecções Comunitárias Adquiridas/diagnóstico
Feminino
Seres Humanos
Masculino
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.12788/jhm.2734


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[PMID]:28460542
[Au] Autor:Verbeek L; Slaghekke F; Sueters M; Middeldorp JM; Klumper FJ; Haak MC; Oepkes D; Lopriore E
[Ad] Endereço:a Division of Neonatology, Department of Pediatrics , Leiden University Medical Center , Leiden , The Netherlands.
[Ti] Título:Hematological disorders at birth in complicated monochorionic twins.
[So] Source:Expert Rev Hematol;10(6):525-532, 2017 06.
[Is] ISSN:1747-4094
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Monochorionic twins are at risk of severe complications including twin-twin transfusion syndrome (TTTS), twin anemia-polycythemia sequence (TAPS) and acute peripartum TTTS. The pathophysiology is based on inter-twin blood transfusion through placental vascular anastomoses. Areas covered: This review focuses on the incidence, management and outcome of neonatal hematological complications at birth in TTTS, TAPS and acute peripartum TTTS. Expert commentary: Hematological disorders are often present at birth in monochorionic twins and include acute or chronic anemia, polycythemia and thrombocytopenia. Routine measurement of complete blood counts in all complicated monochorionic twins is strongly recommended. Increased awareness on these disorders and correct diagnostic tests will lead to prompt and adequate management at birth.
[Mh] Termos MeSH primário: Transfusão Feto-Fetal
Policitemia
Gêmeos
[Mh] Termos MeSH secundário: Contagem de Células Sanguíneas
Feminino
Transfusão Feto-Fetal/sangue
Transfusão Feto-Fetal/etiologia
Transfusão Feto-Fetal/terapia
Seres Humanos
Recém-Nascido
Masculino
Placenta/anormalidades
Placenta/irrigação sanguínea
Policitemia/sangue
Policitemia/congênito
Policitemia/etiologia
Policitemia/terapia
Gravidez
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; TWIN STUDY
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180225
[Lr] Data última revisão:
180225
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1080/17474086.2017.1324290


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[PMID]:29265181
[Au] Autor:Horai M; Satoh S; Matsuo M; Iwanaga M; Horio K; Jo T; Takasaki Y; Kawaguchi Y; Tsushima H; Yoshida S; Taguchi M; Itonaga H; Sawayama Y; Taguchi J; Imaizumi Y; Hata T; Moriuchi Y; Haase D; Yoshiura KI; Miyazaki Y
[Ad] Endereço:Department of Haematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
[Ti] Título:Chromosomal analysis of myelodysplastic syndromes among atomic bomb survivors in Nagasaki.
[So] Source:Br J Haematol;180(3):381-390, 2018 02.
[Is] ISSN:1365-2141
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The myelodysplastic syndromes (MDS) are clonal haematopoietic disorders that develop de novo and also secondary to chemotherapy and/or radiation therapy. We previously demonstrated that the risk of MDS is increased among atomic bomb survivors with significant correlation to radiation dose; however, the clinical characteristics of these survivors have not been well analysed. In this study, we investigated chromosomal abnormalities of MDS among survivors. The frequency of abnormal karyotypes was significantly higher, with more very poor risk karyotypes, according to the revised International Prognostic Scoring System, among those exposed close to the hypocentre compared with unexposed cases. However, abnormal karyotype frequency did not reflect the prognosis of exposed cases with respect to distance from the hypocentre. In addition, there was no difference in prognosis between exposed and unexposed cases. Among proximally exposed cases (<1·5 km from the hypocentre), chromosomal translocations and inversions were more frequent, and the frequency of structural alterations in chromosomes 3, 8, and 11 was significantly increased compared with unexposed cases. These results suggest that chromosomal alterations in MDS among survivors have different features compared with those in de novo or therapy-related MDS. Detailed molecular study is warranted.
[Mh] Termos MeSH primário: Aberrações Cromossômicas
Vítimas de Desastres
Síndromes Mielodisplásicas/epidemiologia
Síndromes Mielodisplásicas/genética
Armas Nucleares
Sobreviventes
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Contagem de Células Sanguíneas
Medula Óssea/patologia
Análise Citogenética
Feminino
Seres Humanos
Japão/epidemiologia
Masculino
Meia-Idade
Síndromes Mielodisplásicas/diagnóstico
Síndromes Mielodisplásicas/terapia
Avaliação de Resultados da Assistência ao Paciente
Sistema de Registros
Análise de Sobrevida
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.1111/bjh.15050


  5 / 19182 MEDLINE  
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[PMID]:29254322
[Au] Autor:De Iuliis V; Dadorante V; Marino A; Griffo I; Pennelli A; Breda V; Robuffo I; Ursi S; Martinotti S; Caputi S; Toniato E
[Ad] Endereço:Department of Medical, Oral and Biotechnological Sciences, University G. d’Annunzio of Chieti, Italy.
[Ti] Título:Cytokine expression profile and blood parameter evaluation of patients undergoing cardiac surgery.
[So] Source:J Biol Regul Homeost Agents;31(4):1109-1113, 2017 Oct-Dec.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Cardiac surgery is accompanied by an important immune response that is poorly understood. This inflammatory response is caused by several stimuli: surgical trauma, cardiopulmonary bypass apparatus, aortic-cross clamping, reperfusion injury and hypothermia. The aim of the present study is to investigate the cytokine level profile involved in the inflammatory pathway of patients undergoing cardiac surgery. One hundred and two patients undergoing elective cardiac surgery utilizing cardiopulmonary bypass (CPB) apparatus were enrolled in the study. In the hematological and biochemical profiles investigated, we observed a significant increase of WBC and blood glucose concentration and a strong decrease of RBC, HB, HCT and PLT 24 h post-surgery compared to baseline and immediately after surgery groups. Furthermore, we found a modulation of cytokine levels mostly for IL-10 and an increase of IL-6, detected at 6 h post-surgery, IL-8 at 6 and 24 h, and TNFα only at 24 h post-surgery. In conclusion, these findings evidence a time course profile on cytokine levels and a balance between pro- and anti-inflammatory cytokine activation during and after cardiac surgery. In fact, IL-6 and IL-10, a pro- and an anti-inflammatory cytokine, respectively, increased immediately after surgery. The plasma level of TNF-α could be inhibited by the high concentration of IL-10 up to 6 h post-surgery. An IL-10 reduction at baseline level, after 24 h post-surgery, could explain a rise of TNF-α plasma concentration. On the other hand, considering the dual role of IL-6 on inflammation acting both as an activator of inflammatory cascade or an anti-inflammatory agent, the increased IL-6 levels 24 h after surgery could be related to the negative feedback action on TNFα activity.
[Mh] Termos MeSH primário: Angina Estável/imunologia
Angina Instável/imunologia
Arritmias Cardíacas/imunologia
Ponte Cardiopulmonar
Infarto do Miocárdio/imunologia
Equilíbrio Th1-Th2/genética
[Mh] Termos MeSH secundário: Idoso
Angina Estável/sangue
Angina Estável/genética
Angina Estável/cirurgia
Angina Instável/sangue
Angina Instável/genética
Angina Instável/cirurgia
Arritmias Cardíacas/sangue
Arritmias Cardíacas/genética
Arritmias Cardíacas/cirurgia
Contagem de Células Sanguíneas
Glicemia/metabolismo
Procedimentos Cirúrgicos Eletivos/métodos
Feminino
Expressão Gênica
Perfilação da Expressão Gênica
Seres Humanos
Imunidade Inata
Interleucina-10/sangue
Interleucina-10/imunologia
Interleucina-6/sangue
Interleucina-6/imunologia
Interleucina-8/sangue
Interleucina-8/imunologia
Masculino
Meia-Idade
Infarto do Miocárdio/sangue
Infarto do Miocárdio/genética
Infarto do Miocárdio/cirurgia
Fator de Necrose Tumoral alfa/sangue
Fator de Necrose Tumoral alfa/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (IL10 protein, human); 0 (IL6 protein, human); 0 (Interleukin-6); 0 (Interleukin-8); 0 (Tumor Necrosis Factor-alpha); 130068-27-8 (Interleukin-10)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE


  6 / 19182 MEDLINE  
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[PMID]:28468206
[Au] Autor:Elbistanli MS; Koçak HE; Acipayam H; Yigider AP; Keskin M; Kayhan FT
[Ad] Endereço:Department of Otorhinolaryngology-Head and Neck Surgery, Bakirköy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
[Ti] Título:The Predictive Value of Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratio for the Effusion Viscosity in Otitis Media With Chronic Effusion.
[So] Source:J Craniofac Surg;28(3):e244-e247, 2017 May.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The objective of the authors' study was to investigate the predictive value of the neutrophil-lymphocyte rate (NLR) and platelet-lymphocyte rate (PLR) in otitis media with effusion and the correlation of the effusion type with these ratios. STUDY DESIGN: Retrospective case-control study. METHODS: One hundred twenty-six pediatric patients diagnosed otitis media with chronic effusion and had ventilation tube inserted between October 2015 and July 2016 were included in the study group and 124 healthy children, who applied for the routine examination and had blood count analysis, were included in the control group. The patients in the study group were divided into 2 groups regarding the effusion viscosity, which was obtained from the patients' operation files. Seventy-one patients were included in the serous group and 55 patients in the mucous group. The NLR and PLR rates of the groups were compared and statistically evaluated. RESULTS: The average NLR and PLR rates were significantly higher in the study group than in the control group (P = 0.000, P = 0.004 respectively). Comparison of the serous and mucous groups with the control group revealed a significant difference between the control group and the serous group regarding the NLR and PLR (P = 0.000; P = 0.000 respectively), but not between the control group and mucous group (P = 0.694; P = 0.691 respectively). CONCLUSION: Neutrophil-lymphocyte rate and PLR had a predictive value for otitis media with effusion and additionally it was a laboratory indicator supporting the typing of the viscosity of the fluid accumulated in the middle ear.
[Mh] Termos MeSH primário: Plaquetas/metabolismo
Exsudatos e Transudatos/química
Linfócitos/metabolismo
Neutrófilos/metabolismo
Otite Média com Derrame/diagnóstico
[Mh] Termos MeSH secundário: Biomarcadores/sangue
Contagem de Células Sanguíneas
Estudos de Casos e Controles
Criança
Doença Crônica
Feminino
Seres Humanos
Masculino
Otite Média com Derrame/sangue
Otite Média com Derrame/imunologia
Otite Média com Derrame/patologia
Valor Preditivo dos Testes
Estudos Retrospectivos
Viscosidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003452


  7 / 19182 MEDLINE  
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[PMID]:29193918
[Au] Autor:López-Díaz T; Lugo F; Rodríguez JM; Sabao E; Sierra K; Valdés Y; Vera J
[Ti] Título:Compliance with management guidelines in patients with suspected dengue.
[So] Source:Bol Asoc Med P R;108(1):51-4, 2016.
[Is] ISSN:0004-4849
[Cp] País de publicação:Puerto Rico
[La] Idioma:eng
[Ab] Resumo:Dengue is an endemic disease in Puerto Rico, with three to nine thousand suspected dengue cases reported yearly. In PR, physicians are required to maintain medical education courses about dengue in order to recertify their medical licenses. The purpose of this study was to describe characteristics of patients admitted to Bella Vista Hospital with suspected dengue and estimate the compliance with guidelines established by the CDC documented in medical records. A total of 197 medical records of patients admitted with diagnosis of suspected dengue during January 1, 2013 through December 31, 2013 were reviewed. The annual distribution of admitted cases showed a higher incidence during the months of June through September, with August having the higher incidence of all. Combined aches and pains were most commonly reported at admission with a prevalence of 82%. In general there was a low prevalence of severe disease as per definition at presentation (DM, clinical fluid accumulation, hepatomegaly, pregnancy and/or renal insufficiency). Overall, compliance with CDC established guidelines were only partially followed. The guideline that was followed more frequently was a daily CBC, with 95% of patients having this as part of their management. Prevalence of administration of isotonic intravenous fluids was 63%, monitoring of vital signs was 48%), and administration of bolus of intravenous fluid was11%. No fatalities were reported during the period.
[Mh] Termos MeSH primário: Dengue/terapia
Fidelidade a Diretrizes
Guias de Prática Clínica como Assunto
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Contagem de Células Sanguíneas
Centers for Disease Control and Prevention (U.S.)
Criança
Pré-Escolar
Estudos Transversais
Dengue/epidemiologia
Feminino
Hidratação/métodos
Seres Humanos
Incidência
Lactente
Recém-Nascido
Soluções Isotônicas/administração & dosagem
Masculino
Meia-Idade
Porto Rico/epidemiologia
Estados Unidos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Isotonic Solutions)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171214
[Lr] Data última revisão:
171214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE


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[PMID]:28467597
[Au] Autor:Cook AM; Moritz A; Freeman KP; Bauer N
[Ad] Endereço:Department of Clinical Sciences, Clinical Pathophysiology and Clinical Pathology, Faculty of Veterinary Medicine, Justus-Liebig-University Gießen, Gießen, Germany.
[Ti] Título:Objective evaluation of analyzer performance based on a retrospective meta-analysis of instrument validation studies: point-of-care hematology analyzers.
[So] Source:Vet Clin Pathol;46(2):248-261, 2017 Jun.
[Is] ISSN:1939-165X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Information on quality requirements and objective evaluation of performance of veterinary point-of-care analyzers (POCAs) is scarce. OBJECTIVES: The study was aimed at assessing observed total errors (TE s) for veterinary hematology POCAs via meta-analysis and comparing TE to allowable total error (TE ) specifications based on experts' opinions. METHODS: The TE for POCAs (impedance and laser-based) was calculated based on data from instrument validation studies published between 2006 and 2013 as follows: TE = 2 × CV [%] + bias [%]. The CV was taken from published studies; the bias was estimated from the regression equation at 2 different concentration levels of measurands. To fulfill quality requirements, TE should be < TE . Measurands were considered as globally acceptable if > 60% of analyzers showed TE < TE . RESULTS: Six studies evaluating 11 analyzers and 5 studies evaluating 5 analyzers were included for canine and feline hematology variables, respectively. For the CBC, TE was < 15% for canine and < 13% for feline measurands, except for HGB and platelet counts. Measurands of the CBC, excluding differential WBC and platelet counts, and HGB concentration were considered globally acceptable. For most of the cell types in the WBC differential count, TE was > TE (data from 3 analyzers). CONCLUSION: This meta-analysis is considered a pilot study. Experts' requirements (TE < TE ) were fulfilled for most measurands except HGB (due to instrument-related bias for the ADVIA 2120) and platelet counts. Available data on the WBC differential count suggest an analytic bias, so nonstatistical quality control is recommended.
[Mh] Termos MeSH primário: Hematologia/instrumentação
Patologia Veterinária/instrumentação
Sistemas Automatizados de Assistência Junto ao Leito
[Mh] Termos MeSH secundário: Animais
Contagem de Células Sanguíneas/instrumentação
Contagem de Células Sanguíneas/veterinária
Doenças do Gato/sangue
Gatos/sangue
Doenças do Cão/sangue
Cães/sangue
Hematologia/normas
Hemoglobinometria/instrumentação
Hemoglobinometria/veterinária
Contagem de Leucócitos/instrumentação
Contagem de Leucócitos/veterinária
Patologia Veterinária/normas
Contagem de Plaquetas/instrumentação
Contagem de Plaquetas/veterinária
Sistemas Automatizados de Assistência Junto ao Leito/normas
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171129
[Lr] Data última revisão:
171129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1111/vcp.12492


  9 / 19182 MEDLINE  
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[PMID]:29068868
[Au] Autor:Lu S; Qiao X; Xie X
[Ad] Endereço:Department of Pediatrics, Tongji Hospital Affiliated to Tongji University, Shanghai, China.
[Ti] Título:Elevated Serum Interleukin-6 Predicts Favorable Response to Immunosuppressive Therapy in Children With Aplastic Anemia.
[So] Source:J Pediatr Hematol Oncol;39(8):614-617, 2017 Nov.
[Is] ISSN:1536-3678
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Immunosuppressive therapy (IST) is the standard treatment for aplastic anemia (AA) children who lack a sibling donor, but the clinical response rate to IST varies. Predictors of response to IST are valuable for stratifying AA patients and making clinical decisions. METHODS: The serum interleukin (IL)-6 levels of 41 AA patients were measured at the time of diagnosis and the response rate of the patients to IST was evaluated at 3, 6, and 12 months after IST. Receiver-operator characteristic (ROC) analysis was used to calculate the predictive value of initial IL-6 levels in determining response at 6 months after IST. RESULTS: The initial IL-6 levels were significant higher in responders than nonresponders at 6 months after IST (211.89 vs. 18.09 pg/mL; P=0.005), using 36.8 pg/mL as a threshold, there were 80% sensitivity and 81% specificity for discriminating responders and nonresponders to IST. Patients with initial high IL-6 level (>36.8 pg/mL) have favorable response rates than those with initial low IL-6 level (<36.8 pg/mL) at 3, 6, and 12 months after IST (P<0.01). CONCLUSION: High levels of IL-6 at the time of diagnosis predict a favorable response to IST in children with AA and this may be helpful for patient's stratification and clinical decisions.
[Mh] Termos MeSH primário: Anemia Aplástica/sangue
Anemia Aplástica/tratamento farmacológico
Imunossupressores/uso terapêutico
Interleucina-6/sangue
[Mh] Termos MeSH secundário: Adolescente
Anemia Aplástica/diagnóstico
Biomarcadores
Contagem de Células Sanguíneas
Criança
Pré-Escolar
Feminino
Seguimentos
Seres Humanos
Imunossupressores/administração & dosagem
Masculino
Curva ROC
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Immunosuppressive Agents); 0 (Interleukin-6)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1097/MPH.0000000000000942


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[PMID]:29045457
[Au] Autor:Mulligan JK; Pasquini WN; Carroll WW; Williamson T; Reaves N; Patel KJ; Mappus E; Schlosser RJ; Atkinson C
[Ad] Endereço:Department of Otolaryngology-Head & Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, United States of America.
[Ti] Título:Dietary vitamin D3 deficiency exacerbates sinonasal inflammation and alters local 25(OH)D3 metabolism.
[So] Source:PLoS One;12(10):e0186374, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) have been shown to be vitamin D3 (VD3) deficient, which is associated with more severe disease and increased polyp size. To gain mechanistic insights into these observational studies, we examined the impact of VD3 deficiency on inflammation and VD3 metabolism in an Aspergillus fumigatus (Af) mouse model of chronic rhinosinusitis (Af-CRS). METHODS: Balb/c mice were fed control or VD3 deficient diet for 4 weeks. Mice were then sensitized with intraperitoneal Af, and one week later given Af intranasally every three days for four weeks while being maintained on control or VD3 deficient diet. Airway function, sinonasal immune cell infiltrate and sinonasal VD3 metabolism profiles were then examined. RESULTS: Mice with VD3 deficiency had increased Penh and sRaw values as compared to controls as well as exacerbated changes in sRaw when coupled with Af-CRS. As compared to controls, VD3 deficient and Af-CRS mice had reduced sinonasal 1α-hydroxylase and the active VD3 metabolite, 1,25(OH)2D3. Differential analysis of nasal lavage samples showed that VD3 deficiency alone and in combination with Af-CRS profoundly upregulated eosinophil, neutrophil and lymphocyte numbers. VD3 deficiency exacerbated increases in monocyte-derived dendritic cell (DC) associated with Af-CRS. Conversely, T-regulatory cells were decreased in both Af-CRS mice and VD3 deficient mice, though coupling VD3 deficiency with Af-CRS did not exacerbate CD4 or T-regulatory cells numbers. Lastly, VD3 deficiency had a modifying or exacerbating impact on nasal lavage levels of IFN-γ, IL-6, IL-10 and TNF-α, but had no impact on IL-17A. CONCLUSIONS: VD3 deficiency causes changes in sinonasal immunity, which in many ways mirrors the changes observed in Af-CRS mice, while selectively exacerbating inflammation. Furthermore, both VD3 deficiency and Af-CRS were associated with altered sinonasal VD3 metabolism causing reductions in local levels of the active VD3 metabolite, 1,25(OH)2D3, even with adequate circulating levels.
[Mh] Termos MeSH primário: Colecalciferol/metabolismo
Inflamação/metabolismo
Pólipos Nasais/metabolismo
Rinite/metabolismo
Sinusite/metabolismo
[Mh] Termos MeSH secundário: Animais
Aspergillus fumigatus/patogenicidade
Contagem de Células Sanguíneas
Dieta
Suplementos Nutricionais
Modelos Animais de Doenças
Eosinófilos/patologia
Seres Humanos
Inflamação/dietoterapia
Inflamação/patologia
Linfócitos/patologia
Camundongos
Lavagem Nasal
Pólipos Nasais/dietoterapia
Pólipos Nasais/patologia
Neutrófilos/patologia
Rinite/dietoterapia
Rinite/patologia
Sinusite/dietoterapia
Sinusite/patologia
Linfócitos T Reguladores/metabolismo
Linfócitos T Reguladores/patologia
Deficiência de Vitamina D/metabolismo
Deficiência de Vitamina D/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
1C6V77QF41 (Cholecalciferol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171019
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186374



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