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  1 / 1173 MEDLINE  
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[PMID]:28763510
[Au] Autor:Oliveira Da Silva W; Pieczarka JC; Ferguson-Smith MA; O'Brien PCM; Mendes-Oliveira AC; Sampaio I; Carneiro J; Nagamachi CY
[Ad] Endereço:Centro de Estudos Avançados da Biodiversidade, Laboratório de Citogenética, Instituto de Ciências Biológicas, Universidade Federal do Pará (UFPA), Belém, Brasil.
[Ti] Título:Chromosomal diversity and molecular divergence among three undescribed species of Neacomys (Rodentia, Sigmodontinae) separated by Amazonian rivers.
[So] Source:PLoS One;12(8):e0182218, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Neacomys genus (Rodentia, Sigmodontinae) is distributed in the Amazon region, with some species limited to a single endemic area, while others may occur more widely. The number of species within the genus and their geographical boundaries are not known accurately, due to their high genetic diversity and difficulties in taxonomic identification. In this work we collected Neacomys specimens from both banks of the Tapajós River in eastern Amazon, and studied them using chromosome painting with whole chromosome probes of Hylaeamys megacephalus (HME; Rodentia, Sigmodontinae), and molecular analysis using haplotypes of mitochondrial genes COI and Cytb. Chromosome painting shows that Neacomys sp. A (NSP-A, 2n = 58/FN = 68) and Neacomys sp. B (NSP-B, 2n = 54/FN = 66) differ by 11 fusion/fission events, one translocation, four pericentric inversions and four heterochromatin amplification events. Using haplotypes of the concatenated mitochondrial genes COI and Cyt b, Neacomys sp. (2n = 58/FN = 64 and 70) shows a mean divergence of 6.2% for Neacomys sp. A and 9.1% for Neacomys sp. B, while Neacomys sp. A and Neacomys sp. B presents a medium nucleotide divergence of 7.4%. Comparisons were made with other published Neacomys data. The Tapajós and Xingu Rivers act as geographic barriers that define the distribution of these Neacomys species. Furthermore, our HME probes reveal four synapomorphies for the Neacomys genus (associations HME 20/[13,22]/4, 6a/21, [9,10]/7b/[9,10] and 12/[16,17]) and demonstrate ancestral traits of the Oryzomyini tribe (HME 8a and 8b, 18 and 25) and Sigmodontinae subfamily (HME 15 and 24), which can be used as taxonomic markers for these groups.
[Mh] Termos MeSH primário: Biodiversidade
Mapeamento Cromossômico
Cromossomos/ultraestrutura
Roedores/genética
[Mh] Termos MeSH secundário: Animais
Teorema de Bayes
Brasil
Coloração Cromossômica
Citocromos b/metabolismo
Complexo IV da Cadeia de Transporte de Elétrons/metabolismo
Feminino
Variação Genética
Geografia
Haplótipos
Hibridização in Situ Fluorescente
Cariotipagem
Funções Verossimilhança
Masculino
Mitocôndrias/genética
Filogenia
Roedores/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
9035-37-4 (Cytochromes b); EC 1.9.3.1 (Electron Transport Complex IV)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170802
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182218


  2 / 1173 MEDLINE  
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[PMID]:28727788
[Au] Autor:Malcher SM; Pieczarka JC; Geise L; Rossi RV; Pereira AL; O'Brien PCM; Asfora PH; Fonsêca da Silva V; Sampaio MI; Ferguson-Smith MA; Nagamachi CY
[Ad] Endereço:Centro de Estudos Avançados da Biodiversidade, Laboratório de Citogenética, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brasil.
[Ti] Título:Oecomys catherinae (Sigmodontinae, Cricetidae): Evidence for chromosomal speciation?
[So] Source:PLoS One;12(7):e0181434, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Among the Oryzomyini (Sigmodontinae), Oecomys is the most speciose, with 17 species. This genus presents high karyotypic diversity (2n = 54 to 2n = 86) and many taxonomic issues at the species level because of the presence of cryptic species and the overlap of morphological characters. For these reasons the real number of species of Oecomys may be underestimated. With the aim of verifying if the taxon Oecomys catherinae is composed of more than one species, we made comparative studies on two populations from two regions of Brazil, one from the Amazon and another from the Atlantic Forest using both classical cytogenetics (G- and C-banding) and comparative genomic mapping with whole chromosome probes of Hylaeamys megacephalus (HME), molecular data (cytochrome b mitochondrial DNA) and morphology. Our results confirm that Oecomys catherinae occurs in the southeast Amazon, and reveal a new karyotype for the species (2n = 62, FNa = 62). The comparative genomic analysis with HME probes identified chromosomal homeologies between both populations and rearrangements that are responsible for the different karyotypes. We compared our results in Sigmodontinae genera with other studies that also used HME probes. These chromosomal differences together with the absence of consistent differentiation between the two populations on morphological and molecular analyses suggest that these populations may represent cryptic species.
[Mh] Termos MeSH primário: Arvicolinae/genética
Sigmodontinae/genética
[Mh] Termos MeSH secundário: Animais
Arvicolinae/anatomia & histologia
Brasil
Coloração Cromossômica
Cromossomos de Mamíferos
Feminino
Hibridização in Situ Fluorescente
Cariótipo
Cariotipagem
Masculino
Filogenia
Sigmodontinae/anatomia & histologia
Especificidade da Espécie
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181434


  3 / 1173 MEDLINE  
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[PMID]:28719894
[Au] Autor:Poplavskaya NS; Romanenko SA; Serdyukova NA; Trifonov VA; Yang F; Nie W; Wang J; Bannikova AA; Surov AV; Lebedev VS
[Ad] Endereço:A.N. Severtsov Institute of Ecology and Evolution, RAS, Moscow State University, Moscow, Russia.
[Ti] Título:Karyotype Evolution and Phylogenetic Relationships of Cricetulus sokolovi Orlov et Malygin 1988 (Cricetidae, Rodentia) Inferred from Chromosomal Painting and Molecular Data.
[So] Source:Cytogenet Genome Res;152(2):65-72, 2017.
[Is] ISSN:1424-859X
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Sokolov's dwarf hamster (Cricetulus sokolovi) is the least studied representative of the striped hamsters (Cricetulus barabensis species group), the taxonomy of which remains controversial. The species was described based on chromosome morphology, but neither the details of the karyotype nor the phylogenetic relationships with other Cricetulus are known. In the present study, the karyotype of C. sokolovi was examined using cross-species chromosome painting. Molecular and cytogenetic data were employed to determine the phylogenetic position of Sokolov's hamster and to analyze the potential pathways of chromosome evolution in Cricetulus. Both the chromosome and molecular data support the species status of Sokolov's hamster. Phylogenetic analysis of the CYTB data placed C. sokolovi as sister to all other striped hamsters (sequence divergence of 8.1%). FISH data revealed that the karyotype of C. sokolovi is highly rearranged, with the most parsimonious scenario of its origin implying at least 4 robertsonian events and a centromere shift. Comparative cytogenetic data on Cricetinae suggest that their evolutionary history includes both periods of chromosomal conservatism and episodes of rapid chromosomal change.
[Mh] Termos MeSH primário: Coloração Cromossômica/métodos
Cromossomos de Mamíferos/genética
Cricetulus/genética
Cariótipo
Filogenia
[Mh] Termos MeSH secundário: Animais
Haplótipos/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.1159/000477521


  4 / 1173 MEDLINE  
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[PMID]:28700625
[Au] Autor:Iannuzzi A; Pereira J; Iannuzzi C; Fu B; Ferguson-Smith M
[Ad] Endereço:Laboratory of Animal Cytogenetics and Genomics, National Research Council of Italy, Institute of Animal Production Systems in Mediterranean Environments (ISPAAM), Naples, Italy.
[Ti] Título:Pooling strategy and chromosome painting characterize a living zebroid for the first time.
[So] Source:PLoS One;12(7):e0180158, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We have investigated the complex karyotype of a living zebra-donkey hybrid for the first time using chromosome-specific painting probes produced from flow-sorted chromosomes from a zebra (Equus burchelli) and horse (Equus caballus). As the chromosomes proved difficult to distinguish from one another, a successful new strategy was devised to resolve the difficulty and characterize each chromosome. This was based on selecting five panels of whole chromosome painting probes that could differentiate zebra and donkey chromosomes by labelling the probes with either FITC or Cy3 fluorochromes. Each panel was hybridized sequentially to the same G-Q-banded metaphases and the results combined so that every zebra and donkey chromosome in each suitable metaphase could be identified. A diploid number of 2n = 53, XY was found, containing haploid sets of 22 chromosomes from the zebra and 31 chromosomes from the donkey, without evidence of chromosome rearrangement. This new strategy, developed for the first time, may have several applications in the resolution of other complex hybrid karyotypes and chromosomal aberrations.
[Mh] Termos MeSH primário: Coloração Cromossômica/métodos
Equidae/genética
Hibridização Genética
[Mh] Termos MeSH secundário: Animais
Cariótipo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180158


  5 / 1173 MEDLINE  
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[PMID]:28501862
[Au] Autor:Degrandi TM; Del Valle Garnero A; O'Brien PCM; Ferguson-Smith MA; Kretschmer R; de Oliveira EHC; Gunski RJ
[Ad] Endereço:Programa de Pós Graduação em Genética, Laboratório de Citogenética e Genética da Conservação Animal, Universidade Federal do Paraná, Curitiba, Brazil.
[Ti] Título:Chromosome Painting in Trogon s. surrucura (Aves, Trogoniformes) Reveals a Karyotype Derived by Chromosomal Fissions, Fusions, and Inversions.
[So] Source:Cytogenet Genome Res;151(4):208-215, 2017.
[Is] ISSN:1424-859X
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Trogons are forest birds with a wide distribution, being found in Africa, Asia, and America, and are included in the order Trogoniformes, family Trogonidae. Phylogenetic studies using molecular data have not been able to determine the phylogenetic relationship among the different genera of trogons. So far, no cytogenetic data for these birds exist. Hence, the aim of this study was to characterize the karyotype of Trogon surrucura surrucura by means of classical and molecular cytogenetics. We found a diploid chromosome number of 2n = 82, similar to most birds, with several derived features compared to chicken and the putative ancestral avian karyotype. T. s. surrucura showed 3 pairs of microchromosomes bearing 18S rDNA clusters. The Z and W sex chromosomes were of similar size but could readily be identified by morphological differences. Using chromosome painting with whole chromosome probes from Gallus gallus and Leucopternis albicollis, we found that the chromosomes homologous to chicken chromosomes 2 and 5 correspond to 2 different pairs in T. s. surrucura and L. albicollis, due to the occurrence of centric fissions. Paracentric inversions were detected in the segment homologous to chicken chromosome 1q, and we confirmed the recurrence of breakpoints when our results were compared to other species of birds already analyzed by FISH or by in silico genome assembly.
[Mh] Termos MeSH primário: Aves/genética
Inversão Cromossômica/genética
Rearranjo Gênico/genética
[Mh] Termos MeSH secundário: Animais
Coloração Cromossômica/métodos
Diploide
Evolução Molecular
Cariótipo
Cariotipagem/métodos
Filogenia
Cromossomos Sexuais/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170515
[St] Status:MEDLINE
[do] DOI:10.1159/000471782


  6 / 1173 MEDLINE  
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[PMID]:28278505
[Au] Autor:Pereira Araújo N; Alves do Espírito Santo A; do Socorro Pereira V; Stanyon R; Svartman M
[Ad] Endereço:Laboratório de Citogenômica Evolutiva, Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
[Ti] Título:Chromosome Painting in Callicebus nigrifrons Provides Insights into the Genome Evolution of Titi Monkeys and the Ancestral Callicebinae Karyotype.
[So] Source:Cytogenet Genome Res;151(2):82-88, 2017.
[Is] ISSN:1424-859X
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:We studied the chromosomes of Callicebus nigrifrons with conventional and molecular cytogenetic methods. Our chromosome painting analysis in C. nigrifrons together with previous reports allowed us to hypothesize an ancestral Callicebinae karyotype with 2n = 48. The associations of human chromosomes (HSA) 2/22, 7/15, 10/11, and the inverted HSA2/16 would link Callicebus, Cheracebus, and Plecturocebus and would thus be present in the ancestral Callicebinae karyotype. Four fusions (HSA1b/1c, 3c/8b, 13/20, and 14/15/3/21) and 1 fission (HSA2/22) are synapomorphies of Callicebus. The associations HSA3/15 and HSA3/9 are chromosome features linking Callicebus and Cheracebus, whereas the association HSA13/17 would represent a link between Callicebus and the moloch group (Plecturocebus). Only 6 of the 33 recognized titi monkey species have now been painted with human chromosome-specific probes. Further analyses are needed to clarify the phylogenomic relationships in this species-rich group.
[Mh] Termos MeSH primário: Coloração Cromossômica/métodos
Pitheciidae/genética
[Mh] Termos MeSH secundário: Animais
Evolução Biológica
Cromossomos de Mamíferos
Evolução Molecular
Feminino
Seres Humanos
Hibridização in Situ Fluorescente
Cariótipo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.1159/000458748


  7 / 1173 MEDLINE  
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[PMID]:28129381
[Au] Autor:Dos Santos MD; Kretschmer R; Frankl-Vilches C; Bakker A; Gahr M; O Brien PC; Ferguson-Smith MA; de Oliveira EH
[Ad] Endereço:Programa de Pós-Graduação em Genética e Biologia Molecular, ICB, UFPA, Belém, PA, Brazil.
[Ti] Título:Comparative Cytogenetics between Two Important Songbird, Models: The Zebra Finch and the Canary.
[So] Source:PLoS One;12(1):e0170997, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Songbird species (order Passeriformes, suborder Oscines) are important models in various experimental fields spanning behavioural genomics to neurobiology. Although the genomes of some songbird species were sequenced recently, the chromosomal organization of these species is mostly unknown. Here we focused on the two most studied songbird species in neuroscience, the zebra finch (Taeniopygia guttata) and the canary (Serinus canaria). In order to clarify these issues and also to integrate chromosome data with their assembled genomes, we used classical and molecular cytogenetics in both zebra finch and canary to define their chromosomal homology, localization of heterochromatic blocks and distribution of rDNA clusters. We confirmed the same diploid number (2n = 80) in both species, as previously reported. FISH experiments confirmed the occurrence of multiple paracentric and pericentric inversions previously found in other species of Passeriformes, providing a cytogenetic signature for this order, and corroborating data from in silico analyses. Additionally, compared to other Passeriformes, we detected differences in the zebra finch karyotype concerning the morphology of some chromosomes, in the distribution of 5S rDNA clusters, and an inversion in chromosome 1.
[Mh] Termos MeSH primário: Canários/genética
Citogenética
Evolução Molecular
Tentilhões/genética
[Mh] Termos MeSH secundário: Animais
Galinhas/genética
Inversão Cromossômica/genética
Coloração Cromossômica
Genômica
Hibridização in Situ Fluorescente
Cariótipo
Cariotipagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170128
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0170997


  8 / 1173 MEDLINE  
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[PMID]:28118403
[Au] Autor:Kus A; Kwasniewska J; Hasterok R
[Ad] Endereço:Department of Plant Anatomy and Cytology, Faculty of Biology and Environmental Protection, University of Silesia in Katowice, Katowice, Poland.
[Ti] Título:Brachypodium distachyon - A Useful Model in the Qualification of Mutagen-Induced Micronuclei Using Multicolor FISH.
[So] Source:PLoS One;12(1):e0170618, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Brachypodium distachyon (Brachypodium) is now intensively utilized as a model grass species in various biological studies. Its favorable cytological features create a unique foundation for a convenient system in mutagenesis, thereby potentially enabling the 'hot spots' and 'cold spots' of DNA damage in its genome to be analyzed. The aim of this study was to analyze the involvement of 5S rDNA, 25S rDNA, the Arabidopsis-type (TTTAGGG)n telomeric sequence and the Brachypodium-originated centromeric BAC clone CB33J12 in the micronuclei formation in Brachypodium root tip cells that were subjected to the chemical clastogenic agent maleic hydrazide (MH). To the best of our knowledge, this is the first use of a multicolor fluorescence in situ hybridization (mFISH) with four different DNA probes being used simultaneously to study plant mutagenesis. A quantitative analysis allowed ten types of micronuclei, which were characterized by the presence or absence of specific FISH signal(s), to be distinguished, thus enabling some specific rules governing the composition of the MH-induced micronuclei with the majority of them originating from the terminal regions of chromosomes, to be identified. The application of rDNA sequences as probes showed that 5S rDNA-bearing chromosomes are involved in micronuclei formation more frequently than the 25S rDNA-bearing chromosomes. These findings demonstrate the promising potential of Brachypodium to be a useful model organism to analyze the effects of various genotoxic agents on the plant nuclear genome stability, especially when the complex FISH-based and chromosome-specific approaches such as chromosome barcoding and chromosome painting will be applied in future studies.
[Mh] Termos MeSH primário: Brachypodium/genética
Coloração Cromossômica/métodos
Cromossomos de Plantas/efeitos dos fármacos
Hidrazida Maleica/farmacologia
Micronúcleos com Defeito Cromossômico/induzido quimicamente
Testes para Micronúcleos/métodos
Mutagênese
Mutagênicos/farmacologia
[Mh] Termos MeSH secundário: Brachypodium/efeitos dos fármacos
Centrômero/efeitos dos fármacos
Centrômero/ultraestrutura
Cromossomos Artificiais Bacterianos/efeitos dos fármacos
Cromossomos de Plantas/ultraestrutura
Sondas de DNA
DNA Ribossômico/genética
Genoma de Planta
Germinação
Interfase
Mitose
Raízes de Plantas
RNA de Plantas/biossíntese
RNA de Plantas/genética
Sementes/efeitos dos fármacos
Telômero/efeitos dos fármacos
Telômero/ultraestrutura
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA Probes); 0 (DNA, Ribosomal); 0 (Mutagens); 0 (RNA, Plant); TQ7L3FCV66 (Maleic Hydrazide)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0170618


  9 / 1173 MEDLINE  
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[PMID]:28117817
[Au] Autor:Pathak R; Koturbash I; Hauer-Jensen M
[Ad] Endereço:Division of Radiation Health, Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences; RPathak@uams.edu.
[Ti] Título:Detection of Inter-chromosomal Stable Aberrations by Multiple Fluorescence In Situ Hybridization (mFISH) and Spectral Karyotyping (SKY) in Irradiated Mice.
[So] Source:J Vis Exp;(119), 2017 Jan 11.
[Is] ISSN:1940-087X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ionizing radiation (IR) induces numerous stable and unstable chromosomal aberrations. Unstable aberrations, where chromosome morphology is substantially compromised, can easily be identified by conventional chromosome staining techniques. However, detection of stable aberrations, which involve exchange or translocation of genetic materials without considerable modification in the chromosome morphology, requires sophisticated chromosome painting techniques that rely on in situ hybridization of fluorescently labeled DNA probes, a chromosome painting technique popularly known as fluorescence in situ hybridization (FISH). FISH probes can be specific for whole chromosome/s or precise sub-region on chromosome/s. The method not only allows visualization of stable aberrations, but it can also allow detection of the chromosome/s or specific DNA sequence/s involved in a particular aberration formation. A variety of chromosome painting techniques are available in cytogenetics; here two highly sensitive methods, multiple fluorescence in situ hybridization (mFISH) and spectral karyotyping (SKY), are discussed to identify inter-chromosomal stable aberrations that form in the bone marrow cells of mice after exposure to total body irradiation. Although both techniques rely on fluorescent labeled DNA probes, the method of detection and the process of image acquisition of the fluorescent signals are different. These two techniques have been used in various research areas, such as radiation biology, cancer cytogenetics, retrospective radiation biodosimetry, clinical cytogenetics, evolutionary cytogenetics, and comparative cytogenetics.
[Mh] Termos MeSH primário: Aberrações Cromossômicas
Hibridização in Situ Fluorescente/métodos
Cariotipagem Espectral/métodos
[Mh] Termos MeSH secundário: Animais
Coloração Cromossômica
Sondas de DNA
Corantes Fluorescentes
Camundongos
Translocação Genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; VIDEO-AUDIO MEDIA
[Nm] Nome de substância:
0 (DNA Probes); 0 (Fluorescent Dyes)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE
[do] DOI:10.3791/55162


  10 / 1173 MEDLINE  
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[PMID]:28100263
[Au] Autor:Santiago F; Lima S; Pinheiro T; Silvestre RT; Otero UB; Tabalipa MM; Kosyakova N; Ornellas MH; Liehr T; Alves G
[Ad] Endereço:Laboratório de Marcadores Circulantes, Departamento de Patologia e Laboratórios, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
[Ti] Título:Benzene poisoning, clinical and blood abnormalities in two Brazilian female gas station attendants: two case reports.
[So] Source:BMC Res Notes;10(1):52, 2017 Jan 18.
[Is] ISSN:1756-0500
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Brazilian gas station workers are chronically exposed to benzene, toluene, xylene (BTX) during their working time. Describe below two cases of latin female gas station workers with benzene poisoning symptoms and miscarriage history. CASE PRESENTATION: In both cases were identified complex chromosomal rearrangements (CCR) with fluorescence in situ hybridization, applied to whole chromosome paints by chromosomes 1, 2 and 4. The lower natural killer cell (NK) cells have also been observed in cases correspondents, especially the rare type of NK (NKbright) in their peripheral blood cells. CONCLUSIONS: It is known that acquired chromosomal aberrations are positively correlated with cancer and reproductive risk. In concordance, lower NK cytotoxicity increases the risk for cancer, as well. Thus, this is the first study providing hints on a possible causative relation of lower NK cytotoxicity and increase rates of chromosomal rearrangements including CCRs.
[Mh] Termos MeSH primário: Benzeno/envenenamento
Exposição Ocupacional/efeitos adversos
[Mh] Termos MeSH secundário: Aborto Espontâneo
Adulto
Aberrações Cromossômicas
Coloração Cromossômica
Cromossomos/ultraestrutura
Feminino
Rearranjo Gênico
Seres Humanos
Hibridização in Situ Fluorescente
Células Matadoras Naturais/citologia
Fatores de Tempo
Tolueno/envenenamento
Xilenos/envenenamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Xylenes); 3FPU23BG52 (Toluene); J64922108F (Benzene)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170120
[St] Status:MEDLINE
[do] DOI:10.1186/s13104-016-2369-8



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