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Pesquisa : E01.370.225.500.620.670.570 [Categoria DeCS]
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[PMID]:28451637
[Au] Autor:Sun Y; Grieco SF; Holmes TC; Xu X
[Ad] Endereço:Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA 92697-1275.
[Ti] Título:Local and Long-Range Circuit Connections to Hilar Mossy Cells in the Dentate Gyrus.
[So] Source:eNeuro;4(2), 2017 Mar-Apr.
[Is] ISSN:2373-2822
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hilar mossy cells are the prominent glutamatergic cell type in the dentate hilus of the dentate gyrus (DG); they have been proposed to have critical roles in the DG network. To better understand how mossy cells contribute to DG function, we have applied new viral genetic and functional circuit mapping approaches to quantitatively map and compare local and long-range circuit connections of mossy cells and dentate granule cells in the mouse. The great majority of inputs to mossy cells consist of two parallel inputs from within the DG: an excitatory input pathway from dentate granule cells and an inhibitory input pathway from local DG inhibitory neurons. Mossy cells also receive a moderate degree of excitatory and inhibitory CA3 input from proximal CA3 subfields. Long range inputs to mossy cells are numerically sparse, and they are only identified readily from the medial septum and the septofimbrial nucleus. In comparison, dentate granule cells receive most of their inputs from the entorhinal cortex. The granule cells receive significant synaptic inputs from the hilus and the medial septum, and they also receive direct inputs from both distal and proximal CA3 subfields, which has been underdescribed in the existing literature. Our slice-based physiological mapping studies further supported the identified circuit connections of mossy cells and granule cells. Together, our data suggest that hilar mossy cells are major local circuit integrators and they exert modulation of the activity of dentate granule cells as well as the CA3 region through "back-projection" pathways.
[Mh] Termos MeSH primário: Hipocampo/citologia
Fibras Musgosas Hipocampais/anatomia & histologia
[Mh] Termos MeSH secundário: Potenciais de Ação
Animais
Neurônios Colinérgicos/citologia
Feminino
Neurônios GABAérgicos/citologia
Hipocampo/fisiologia
Masculino
Camundongos Endogâmicos C57BL
Fibras Musgosas Hipocampais/fisiologia
Inibição Neural
Vias Neurais/citologia
Vias Neurais/fisiologia
Técnicas de Rastreamento Neuroanatômico
Núcleos Septais/citologia
Sinapses
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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[PMID]:28463345
[Au] Autor:Upadhyaya MA; Nasrallah HA
[Ad] Endereço:The Everest Foundation, Los Angeles, CA USA E-mail: mupadhya@bronxleb.org
[Ti] Título:The intense desire for healthy limb amputation: A dis-proprioceptive neuropsychiatric disorder.
[So] Source:Ann Clin Psychiatry;29(2):125-132, 2017 05.
[Is] ISSN:1547-3325
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The first mention of a condition in which apparently nonpsychotic individuals have a strong, unrelenting desire to amputate ≥1 of their healthy limbs was published nearly 4 decades ago. Once dismissed as a paraphilia, the condition in recent years has been re-investigated with neurologic testing and imaging, yielding evidence suggesting it may be attributable to a neuroanatomical anomaly. METHODS: A literature review of data was conducted of recently published studies with pinprick testing, magnetic resonance imaging (MRI)/functional MRI imaging, magnetoencephalography, and interviews of individuals with a desire for limb amputation. RESULTS: Published literature on this condition features studies with a limited number of participants. However, the results indicate that affected individuals predominantly desire amputation of the left lower limb, and correspondingly, usually have changes in cortical thickness in the right parietal lobe. CONCLUSIONS: Further investigation of this condition is warranted, particularly, more research into the precise nature of the anomalous neuroanatomy, biopsychosocial background of those with the condition, and longitudinal perspective of the childhood onset and evolution of symptoms. Large sample studies involving a collaborative effort across multiple sites are required.
[Mh] Termos MeSH primário: Amputação/psicologia
Transtornos Dismórficos Corporais
Técnicas de Rastreamento Neuroanatômico/métodos
Distúrbios Somatossensoriais
[Mh] Termos MeSH secundário: Transtornos Dismórficos Corporais/patologia
Transtornos Dismórficos Corporais/psicologia
Lateralidade Funcional
Seres Humanos
Imagem por Ressonância Magnética/métodos
Testes Neuropsicológicos
Distúrbios Somatossensoriais/patologia
Distúrbios Somatossensoriais/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:28951448
[Au] Autor:Albisetti GW; Ghanem A; Foster E; Conzelmann KK; Zeilhofer HU; Wildner H
[Ad] Endereço:Institute of Pharmacology and Toxicology, University of Zurich, CH-8057 Zürich, Switzerland.
[Ti] Título:Identification of Two Classes of Somatosensory Neurons That Display Resistance to Retrograde Infection by Rabies Virus.
[So] Source:J Neurosci;37(43):10358-10371, 2017 Oct 25.
[Is] ISSN:1529-2401
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Glycoprotein-deleted rabies virus-mediated monosynaptic tracing has become a standard method for neuronal circuit mapping, and is applied to virtually all parts of the rodent nervous system, including the spinal cord and primary sensory neurons. Here we identified two classes of unmyelinated sensory neurons (nonpeptidergic and C-fiber low-threshold mechanoreceptor neurons) resistant to direct and trans-synaptic infection from the spinal cord with rabies viruses that carry glycoproteins in their envelopes and that are routinely used for infection of CNS neurons (SAD-G and N2C-G). However, the same neurons were susceptible to infection with EnvA-pseudotyped rabies virus in tumor virus A receptor transgenic mice, indicating that resistance to retrograde infection was due to impaired virus adsorption rather than to deficits in subsequent steps of infection. These results demonstrate an important limitation of rabies virus-based retrograde tracing of sensory neurons in adult mice, and may help to better understand the molecular machinery required for rabies virus spread in the nervous system. In this study, mice of both sexes were used. To understand the neuronal bases of behavior, it is important to identify the underlying neural circuitry. Rabies virus-based monosynaptic tracing has been used to identify neuronal circuits in various parts of the nervous system. This has included connections between peripheral sensory neurons and their spinal targets. These connections form the first synapse in the somatosensory pathway. Here we demonstrate that two classes of unmyelinated sensory neurons, which account for >40% of dorsal root ganglia neurons, display resistance to rabies infection. Our results are therefore critical for interpreting monosynaptic rabies-based tracing in the sensory system. In addition, identification of rabies-resistant neurons might provide a means for future studies addressing rabies pathobiology.
[Mh] Termos MeSH primário: Gânglios Espinais/química
Rede Nervosa/química
Técnicas de Rastreamento Neuroanatômico/métodos
Vírus da Raiva
Células Receptoras Sensoriais/química
[Mh] Termos MeSH secundário: Animais
Feminino
Gânglios Espinais/citologia
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
Rede Nervosa/citologia
Células do Corno Posterior/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171115
[Lr] Data última revisão:
171115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE
[do] DOI:10.1523/JNEUROSCI.1277-17.2017


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[PMID]:28710326
[Au] Autor:Eisen A; Braak H; Del Tredici K; Lemon R; Ludolph AC; Kiernan MC
[Ad] Endereço:Division of Neurology, University of British Columbia, Vancouver, British Columbia, Canada.
[Ti] Título:Cortical influences drive amyotrophic lateral sclerosis.
[So] Source:J Neurol Neurosurg Psychiatry;88(11):917-924, 2017 Nov.
[Is] ISSN:1468-330X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The early motor manifestations of sporadic amyotrophic lateral sclerosis (ALS), while rarely documented, reflect failure of adaptive complex motor skills. The development of these skills correlates with progressive evolution of a direct corticomotoneuronal system that is unique to primates and markedly enhanced in humans. The failure of this system in ALS may translate into the split hand presentation, gait disturbance, split leg syndrome and bulbar symptomatology related to vocalisation and breathing, and possibly diffuse fasciculation, characteristic of ALS. Clinical neurophysiology of the brain employing transcranial magnetic stimulation has convincingly demonstrated a presymptomatic reduction or absence of short interval intracortical inhibition, accompanied by increased intracortical facilitation, indicating cortical hyperexcitability. The hallmark of the TDP-43 pathological signature of sporadic ALS is restricted to cortical areas as well as to subcortical nuclei that are under the direct control of corticofugal projections. This provides anatomical support that the origins of the TDP-43 pathology reside in the cerebral cortex itself, secondarily in corticofugal fibres and the subcortical targets with which they make monosynaptic connections. The latter feature explains the multisystem degeneration that characterises ALS. Consideration of ALS as a primary neurodegenerative disorder of the human brain may incorporate concepts of prion-like spread at synaptic terminals of corticofugal axons. Further, such a concept could explain the recognised widespread imaging abnormalities of the ALS neocortex and the accepted relationship between ALS and frontotemporal dementia.
[Mh] Termos MeSH primário: Esclerose Amiotrófica Lateral/fisiopatologia
Córtex Cerebral/fisiopatologia
Proteinopatias TDP-43/fisiopatologia
[Mh] Termos MeSH secundário: Esclerose Amiotrófica Lateral/diagnóstico
Esclerose Amiotrófica Lateral/patologia
Axônios/patologia
Axônios/fisiologia
Córtex Cerebral/patologia
Progressão da Doença
Diagnóstico Precoce
Demência Frontotemporal/diagnóstico
Demência Frontotemporal/patologia
Demência Frontotemporal/fisiopatologia
Seres Humanos
Inibição Neural/fisiologia
Vias Neurais/fisiopatologia
Técnicas de Rastreamento Neuroanatômico
Neuroimagem
Terminações Pré-Sinápticas/patologia
Terminações Pré-Sinápticas/fisiologia
Proteinopatias TDP-43/diagnóstico
Estimulação Magnética Transcraniana
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171114
[Lr] Data última revisão:
171114
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170716
[St] Status:MEDLINE
[do] DOI:10.1136/jnnp-2017-315573


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[PMID]:28542213
[Au] Autor:Gross C; Ellison B; Buchman AS; Terasawa E; VanderHorst VG
[Ad] Endereço:Department of Neurology, Division of Movement Disorders, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.
[Ti] Título:A novel approach for assigning levels to monkey and human lumbosacral spinal cord based on ventral horn morphology.
[So] Source:PLoS One;12(5):e0177243, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Proper identification of spinal cord levels is crucial for clinical-pathological and imaging studies in humans, but can be a challenge given technical limitations. We have previously demonstrated in non-primate models that the contours of the spinal ventral horn are determined by the position of motoneuron pools. These positions are preserved within and among individuals and can be used to identify lumbosacral spinal levels. Here we tested the hypothesis that this approach can be extended to identify monkey and human spinal levels. In 7 rhesus monkeys, we retrogradely labeled motoneuron pools that represent rostral, middle and caudal landmarks of the lumbosacral enlargement. We then aligned the lumbosacral enlargements among animals using absolute length, segmental level or a relative scale based upon rostral and caudal landmarks. Inter-animal matching of labeled motoneurons across the lumbosacral enlargement was most precise when using internal landmarks. We then reconstructed 3 human lumbosacral spinal cords, and aligned these based upon homologous internal landmarks. Changes in shape of the ventral horn were consistent among human subjects using this relative scale, despite marked differences in absolute length or age. These data suggest that the relative position of spinal motoneuron pools is conserved across species, including primates. Therefore, in clinical-pathological or imaging studies in humans, one can assign spinal cord levels to even single sections by matching ventral horn shape to standardized series.
[Mh] Termos MeSH primário: Células do Corno Anterior/citologia
Região Lombossacral/anatomia & histologia
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Animais
Gatos
Feminino
Fixadores
Formaldeído
Seres Humanos
Macaca mulatta
Masculino
Meia-Idade
Técnicas de Rastreamento Neuroanatômico
Marcadores do Trato Nervoso
Especificidade da Espécie
Fixação de Tecidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fixatives); 0 (Neuronal Tract-Tracers); 1HG84L3525 (Formaldehyde)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0177243


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[PMID]:28514446
[Au] Autor:Chung S; Weber F; Zhong P; Tan CL; Nguyen TN; Beier KT; Hörmann N; Chang WC; Zhang Z; Do JP; Yao S; Krashes MJ; Tasic B; Cetin A; Zeng H; Knight ZA; Luo L; Dan Y
[Ad] Endereço:Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, Berkeley, California 94720, USA.
[Ti] Título:Identification of preoptic sleep neurons using retrograde labelling and gene profiling.
[So] Source:Nature;545(7655):477-481, 2017 05 25.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In humans and other mammalian species, lesions in the preoptic area of the hypothalamus cause profound sleep impairment, indicating a crucial role of the preoptic area in sleep generation. However, the underlying circuit mechanism remains poorly understood. Electrophysiological recordings and c-Fos immunohistochemistry have shown the existence of sleep-active neurons in the preoptic area, especially in the ventrolateral preoptic area and median preoptic nucleus. Pharmacogenetic activation of c-Fos-labelled sleep-active neurons has been shown to induce sleep. However, the sleep-active neurons are spatially intermingled with wake-active neurons, making it difficult to target the sleep neurons specifically for circuit analysis. Here we identify a population of preoptic area sleep neurons on the basis of their projection target and discover their molecular markers. Using a lentivirus expressing channelrhodopsin-2 or a light-activated chloride channel for retrograde labelling, bidirectional optogenetic manipulation, and optrode recording, we show that the preoptic area GABAergic neurons projecting to the tuberomammillary nucleus are both sleep active and sleep promoting. Furthermore, translating ribosome affinity purification and single-cell RNA sequencing identify candidate markers for these neurons, and optogenetic and pharmacogenetic manipulations demonstrate that several peptide markers (cholecystokinin, corticotropin-releasing hormone, and tachykinin 1) label sleep-promoting neurons. Together, these findings provide easy genetic access to sleep-promoting preoptic area neurons and a valuable entry point for dissecting the sleep control circuit.
[Mh] Termos MeSH primário: Técnicas de Rastreamento Neuroanatômico
Neurônios/fisiologia
Área Pré-Óptica/citologia
Área Pré-Óptica/fisiologia
Sono/fisiologia
Transcriptoma
[Mh] Termos MeSH secundário: Animais
Biomarcadores/análise
Channelrhodopsins
Canais de Cloreto/metabolismo
Canais de Cloreto/efeitos da radiação
Colecistocinina/análise
Colecistocinina/genética
Hormônio Liberador da Corticotropina/análise
Hormônio Liberador da Corticotropina/genética
Feminino
Neurônios GABAérgicos/metabolismo
Neurônios GABAérgicos/efeitos da radiação
Região Hipotalâmica Lateral/fisiologia
Masculino
Camundongos
Neurônios/efeitos dos fármacos
Neurônios/efeitos da radiação
Optogenética
Área Pré-Óptica/efeitos dos fármacos
Área Pré-Óptica/efeitos da radiação
Proteínas Proto-Oncogênicas c-fos/análise
Proteínas Proto-Oncogênicas c-fos/metabolismo
Ribossomos/metabolismo
Análise de Sequência de RNA
Análise de Célula Única
Sono/efeitos dos fármacos
Sono/efeitos da radiação
Taquicininas/análise
Taquicininas/genética
Vigília/fisiologia
Vigília/efeitos da radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biomarkers); 0 (Channelrhodopsins); 0 (Chloride Channels); 0 (Proto-Oncogene Proteins c-fos); 0 (Tachykinins); 9011-97-6 (Cholecystokinin); 9015-71-8 (Corticotropin-Releasing Hormone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171117
[Lr] Data última revisão:
171117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170518
[St] Status:MEDLINE
[do] DOI:10.1038/nature22350


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[PMID]:28504672
[Au] Autor:Roberts TF; Hisey E; Tanaka M; Kearney MG; Chattree G; Yang CF; Shah NM; Mooney R
[Ad] Endereço:Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
[Ti] Título:Identification of a motor-to-auditory pathway important for vocal learning.
[So] Source:Nat Neurosci;20(7):978-986, 2017 Jul.
[Is] ISSN:1546-1726
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Learning to vocalize depends on the ability to adaptively modify the temporal and spectral features of vocal elements. Neurons that convey motor-related signals to the auditory system are theorized to facilitate vocal learning, but the identity and function of such neurons remain unknown. Here we identify a previously unknown neuron type in the songbird brain that transmits vocal motor signals to the auditory cortex. Genetically ablating these neurons in juveniles disrupted their ability to imitate features of an adult tutor's song. Ablating these neurons in adults had little effect on previously learned songs but interfered with their ability to adaptively modify the duration of vocal elements and largely prevented the degradation of songs' temporal features that is normally caused by deafening. These findings identify a motor to auditory circuit essential to vocal imitation and to the adaptive modification of vocal timing.
[Mh] Termos MeSH primário: Córtex Auditivo/fisiologia
Vias Auditivas/fisiologia
Aprendizagem/fisiologia
Telencéfalo/fisiologia
Vocalização Animal/fisiologia
[Mh] Termos MeSH secundário: Envelhecimento/fisiologia
Animais
Animais Geneticamente Modificados
Contagem de Células
Surdez/fisiopatologia
Tentilhões
Masculino
Vias Neurais/fisiologia
Técnicas de Rastreamento Neuroanatômico
Neurônios/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171115
[Lr] Data última revisão:
171115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170516
[St] Status:MEDLINE
[do] DOI:10.1038/nn.4563


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[PMID]:28323088
[Au] Autor:Leonard AV; Menendez JY; Pat BM; Hadley MN; Floyd CL
[Ad] Endereço:Spain Rehabilitation Center, Department of Physical Medicine and Rehabilitation, School of Medicine, The University of Alabama at Birmingham, USA; Discipline of Anatomy and Pathology, School of Medicine, The University of Adelaide, Australia. Electronic address: anna.leonard@adelaide.edu.au.
[Ti] Título:Localization of the corticospinal tract within the porcine spinal cord: Implications for experimental modeling of traumatic spinal cord injury.
[So] Source:Neurosci Lett;648:1-7, 2017 May 01.
[Is] ISSN:1872-7972
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Spinal cord injury (SCI) researchers have predominately utilized rodents for SCI modeling and experimentation. Unfortunately, a large number of novel therapies developed in rodent models have failed to demonstrate efficacy in human clinical trials which suggests that improved animal models are an important translational tool. Recently, porcine models of SCI have been identified as a valuable intermediary model for preclinical evaluation of promising therapies to aid clinical translation. However, the localization of the major spinal tracts in pigs has not yet been described. Given that significant differences exist in the location of the corticospinal tract (CST) between rodents and humans, determining its location in pigs will provide important information related to the translational potential of the porcine pre-clinical model of SCI. Thus, the goal of this study is to investigate the localization of the CST within the porcine spinal cord. Mature female domestic pigs (n=4, 60kg) received microinjections of fluorescent dextran tracers (Alexa Fluor, 10,000MW) into the primary motor cortex, using image-guided navigation (StealthStation ), to label the CST. At 5 weeks post-tracer injection animals were euthanized, the entire neuroaxis harvested and processed for histological examination. Serial sections of the brain and spinal cord were prepared and imaged using confocal microscopy to observe the location of the CST in pigs. Results demonstrate that the CST of pigs is located in the lateral white matter, signifying greater similarity to human anatomical structure compared to that of rodents. We conclude that the corticospinal tract in pigs demonstrates anatomical similarity to human, suggesting that the porcine model has importance as a translational intermediary pre-clinical model.
[Mh] Termos MeSH primário: Modelos Animais de Doenças
Córtex Motor/anatomia & histologia
Tratos Piramidais/anatomia & histologia
Traumatismos da Medula Espinal/patologia
Suínos/anatomia & histologia
[Mh] Termos MeSH secundário: Animais
Feminino
Imagem por Ressonância Magnética
Técnicas de Rastreamento Neuroanatômico
Especificidade da Espécie
Substância Branca/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE


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[PMID]:28263300
[Au] Autor:Li Y; Xu J; Liu Y; Zhu J; Liu N; Zeng W; Huang N; Rasch MJ; Jiang H; Gu X; Li X; Luo M; Li C; Teng J; Chen J; Zeng S; Lin L; Zhang X
[Ad] Endereço:Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
[Ti] Título:A distinct entorhinal cortex to hippocampal CA1 direct circuit for olfactory associative learning.
[So] Source:Nat Neurosci;20(4):559-570, 2017 Apr.
[Is] ISSN:1546-1726
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lateral and medial parts of entorhinal cortex (EC) convey nonspatial 'what' and spatial 'where' information, respectively, into hippocampal CA1, via both the indirect EC layer 2→ hippocampal dentate gyrus→CA3→CA1 and the direct EC layer 3→CA1 paths. However, it remains elusive how the direct path transfers distinct information and contributes to hippocampal learning functions. Here we report that lateral EC projection neurons selectively form direct excitatory synapses onto a subpopulation of morphologically complex, calbindin-expressing pyramidal cells (PCs) in the dorsal CA1 (dCA1), while medial EC neurons uniformly innervate all dCA1 PCs. Optogenetically inactivating the distinct lateral EC-dCA1 connections or the postsynaptic dCA1 calbindin-expressing PC activity slows olfactory associative learning. Moreover, optetrode recordings reveal that dCA1 calbindin-expressing PCs develop more selective spiking responses to odor cues during learning. Thus, our results identify a direct lateral EC→dCA1 circuit that is required for olfactory associative learning.
[Mh] Termos MeSH primário: Aprendizagem por Associação/fisiologia
Região CA1 Hipocampal/fisiologia
Córtex Entorrinal/fisiologia
Percepção Olfatória/fisiologia
[Mh] Termos MeSH secundário: Animais
Calbindinas/metabolismo
Masculino
Camundongos
Camundongos Transgênicos
Vias Neurais/fisiologia
Técnicas de Rastreamento Neuroanatômico
Neurônios/fisiologia
Odorantes
Células Piramidais/metabolismo
Células Piramidais/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Calbindins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170307
[St] Status:MEDLINE
[do] DOI:10.1038/nn.4517


  10 / 501 MEDLINE  
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[PMID]:28231568
[Au] Autor:Imura K; Yamamoto N; Yoshimoto M; Endo M; Funakoshi K; Ito H
[Ad] Endereço:Department of Neuroanatomy, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
[Ti] Título:Fiber Connections of the Caudal Corpus Cerebelli, with Special Reference to the Intrinsic Circuitry, in a Teleost (Oreochromis niloticus).
[So] Source:Brain Behav Evol;89(1):15-32, 2017.
[Is] ISSN:1421-9743
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The caudal part of the corpus cerebelli of Nile tilapia can be divided into dorsal and ventral regions. The granule cell layer of the dorsal (dGL) and ventral (vGL) regions of the caudal corpus cerebelli is known to receive indirect inputs from the telencephalon relayed by the nucleus paracommissuralis. The descending pathways are topographically organized, and the dGL and vGL receive inputs from different dorsal telencephalic parts. The caudal corpus cerebelli, in turn, projects extracerebellar efferents. However, it remains unknown how the descending telencephalic inputs are processed within the cerebellum. Therefore, the present study investigated intrinsic connections of the caudal corpus cerebelli by injecting neural tracers into the molecular layer of dorsal and ventral regions. Injections of tracers into the ventral molecular layer resulted in labeled cells in the vGL and the ganglionic layer of the ventral corpus. The axonal trajectories from labeled cells in the ganglionic layer were analyzed in detail via single-axon reconstructions, which suggested that the terminal portions were confined to the ganglionic layer of the dorsal corpus. No labeled terminals were observed outside the caudal corpus cerebelli. Tracer applications to the dorsal molecular layer resulted in labeled cells not only in the ganglionic layer and the granule cell layer of the dorsal corpus but also in the ganglionic layer of the ventral corpus. The latter finding confirms the presence of intrinsic projections from the ventral region to the dorsal region in the caudal corpus cerebelli. We further revealed that the intrinsic projection neurons are Purkinje cells by immunohistochemistry for zebrin II (aldolase C), which is a marker of Purkinje cells, combined with tracer injections into the dorsal corpus. Unlike injections into the ventral corpus, injections into the dorsal corpus resulted in labeled terminals in extracerebellar structures, such as the nucleus of the medial longitudinal fascicle and reticular formation. The present study suggests that indirect inputs from different telencephalic parts received and processed by distinct regions of caudal corpus cerebelli are sent out of the corpus through the efferent neurons in the dorsal corpus.
[Mh] Termos MeSH primário: Cerebelo/citologia
Ciclídeos/anatomia & histologia
Vias Neurais/citologia
Técnicas de Rastreamento Neuroanatômico/métodos
Células de Purkinje/citologia
[Mh] Termos MeSH secundário: Animais
Feminino
Masculino
Fibras Nervosas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170224
[St] Status:MEDLINE
[do] DOI:10.1159/000455962



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