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  1 / 30730 MEDLINE  
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[PMID]:29363738
[Au] Autor:Willen SM; Rodeghier M; Strunk RC; Bacharier LB; Rosen CL; Kirkham FJ; DeBaun MR; Cohen RT
[Ad] Endereço:Department of Pediatrics, Division of Hematology/Oncology, Vanderbilt-Meharry Center for Excellence in Sickle Cell Disease, Vanderbilt University Medical Center, Nashville, TN, USA.
[Ti] Título:Aeroallergen sensitization predicts acute chest syndrome in children with sickle cell anaemia.
[So] Source:Br J Haematol;180(4):571-577, 2018 02.
[Is] ISSN:1365-2141
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Asthma is associated with higher rates of acute chest syndrome (ACS) and vaso-occlusive pain episodes among children with sickle cell anaemia (SCA). Aeroallergen sensitization is a risk factor for asthma. We hypothesized that aeroallergen sensitization is associated with an increased incidence of hospitalizations for ACS and pain. Participants in a multicentre, longitudinal cohort study, aged 4-18 years with SCA, underwent skin prick testing to ten aeroallergens. ACS and pain episodes were collected from birth until the end of the follow-up period. The number of positive skin tests were tested for associations with prospective rates of ACS and pain. Multivariable models demonstrated additive effects of having positive skin tests on future rates of ACS (incidence rate ratio (IRR) for each positive test 1·23, 95% confidence interval [CI] 1·11-1·36, P < 0·001). Aeroallergen sensitization was not associated with future pain (IRR 1·14, 95%CI 0·97-1·33, P = 0·11). Our study demonstrated that children with SCA and aeroallergen sensitization are at increased risk for future ACS. Future research is needed to determine whether identification of specific sensitizations and allergen avoidance and treatment reduce the risk of ACS for children with SCA.
[Mh] Termos MeSH primário: Síndrome Torácica Aguda/diagnóstico
Síndrome Torácica Aguda/etiologia
Alérgenos/imunologia
Anemia Falciforme/complicações
[Mh] Termos MeSH secundário: Adolescente
Aerossóis
Biomarcadores
Criança
Pré-Escolar
Feminino
Seguimentos
Seres Humanos
Hipersensibilidade/complicações
Hipersensibilidade/imunologia
Imunização
Masculino
Morbidade
Medição da Dor
Prognóstico
Estudos Prospectivos
Testes Cutâneos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Aerosols); 0 (Allergens); 0 (Biomarkers)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.1111/bjh.15076


  2 / 30730 MEDLINE  
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[PMID]:29338164
[Au] Autor:Novkovic D; Petrovic M; Zivkovic V; Baletic N
[Ti] Título:The relation between nonspecific hyperreactivity of the airways and atopic constitution in asthmatics.
[So] Source:Vojnosanit Pregl;73(11):1056-9, 2016 Nov.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Background/Aim: Hyperreactivity of the airways caused by inflammation in asthmatics is the most important pathophysiological change. It represents a suitable ground that in the presence of risk factors and the drivers of asthma, asthmatic attack occurs. Atopic constitution is one of the most important risk factors for the development and expression of asthma. The aim of our study was to investigate the relationship between nonspecific airway hyperreactivity and atopic constituton in asthmatics. Methods: This retrospective analysis was conducted considering the results of nonspecific bronchoprovocative test with histamine, skin tests to inhalant allergens and total IgE levels in the serum of asthmatic patients with controlled bronchial asthma. The sample consisted of 162 asthmatics examined during one-year period. Results: The examinees were male asthmatic patients, aged between 18 and 30 years. We found that the examinees with a pronounced non-specific hyperreactivity had more significant skin reaction to inhaled allergens and higher levels of total IgE in serum. Conclusion: The results of our study show that the intensity of airway hyperresponsiveness to histamine in asthmatics is directly related to atopic constitution.
[Mh] Termos MeSH primário: Asma/fisiopatologia
Hiper-Reatividade Brônquica/fisiopatologia
Broncoconstrição
Dermatite Atópica/imunologia
Pulmão/fisiopatologia
[Mh] Termos MeSH secundário: Administração por Inalação
Adolescente
Adulto
Asma/diagnóstico
Asma/imunologia
Biomarcadores/sangue
Hiper-Reatividade Brônquica/diagnóstico
Hiper-Reatividade Brônquica/imunologia
Testes de Provocação Brônquica
Dermatite Atópica/sangue
Dermatite Atópica/diagnóstico
Histamina/administração & dosagem
Seres Humanos
Imunoglobulina E/sangue
Pulmão/imunologia
Masculino
Estudos Retrospectivos
Fatores de Risco
Testes Cutâneos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 37341-29-0 (Immunoglobulin E); 820484N8I3 (Histamine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.2298/VSP141029120N


  3 / 30730 MEDLINE  
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[PMID]:29284253
[Au] Autor:Spiewak R; Góra-Florek A; Horoch A; Jarosz MJ; Dorynska A; Golec M; Dutkiewicz J
[Ad] Endereço:Department of Experimental Dermatology and Cosmetology, Jagiellonian University Medical College, Krakow, Poland. spiewak.eu@gmail.com.
[Ti] Título:Risk factors for work-related eczema and urticaria among vocational students of agriculture.
[So] Source:Ann Agric Environ Med;24(4):716-721, 2017 Dec 23.
[Is] ISSN:1898-2263
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION AND OBJECTIVE: Farmers are at high risk of occupational skin diseases which may start already during vocational training. This study was aimed at identification of risk factors for work-related skin diseases among vocational students of agriculture. MATERIAL AND METHODS: The study involved 440 students (245 males, 195 females aged 17-21 years) in 11 vocational schools which were at least 100 km from each other. The protocol included a physician-managed questionnaire and medical examination, skin prick tests, patch tests, total IgE and Phadiatop. Logistic regression model was used for the identification of relevant risk factors. RESULTS: Work-related dermatoses were diagnosed in 29 study participants (6.6%, 95%CI: 4.3-8.9%): eczema in 22, urticaria in 14, and co-existence of both in 7 students. Significant risk factors for work-related eczema were: history of respiratory allergy (OR=10.10; p<0.001), history of eczema (itchy rash) provoked by wet work and detergents before entering the school (OR=5.85; p<0.001), as well as history of contact dermatitis to metals, rubber or cosmetics prior to inscription (OR=2.84; p=0.016), and family history of any skin disease (OR=2.99; p=0.013). Significant risk factors for work-related urticaria were: history of allergic rhinitis and asthma prior to inscription (OR=7.29; p=0.006), positive skin prick tests to work place allergens (OR=4.65; p=0.002) and to environmental allergens (OR=3.79; p=0.009), and positive Phadiatop test (OR=3.61; p=0.013). CONCLUSIONS: Work-related skin diseases are common among vocational students of agriculture. Atopy, past history of asthma, allergic rhinitis, and eczema (either atopic, allergic or irritant) are relevant risk factors for work-related eczema and urticaria in young farmers, along with family history of any skin disease. Positive skin prick tests seem relevant, especially in the case of urticaria. Asking simple, aimed questions during health checks while enrolling students into agricultural schools would suffice to identify students at risk for work-related eczema and urticaria, giving them the chance for selecting a safer profession, and hopefully avoiding an occupational disease in the future.
[Mh] Termos MeSH primário: Doenças dos Trabalhadores Agrícolas/epidemiologia
Eczema/epidemiologia
Urticária/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Doenças dos Trabalhadores Agrícolas/diagnóstico
Agricultura
Eczema/diagnóstico
Fazendeiros/estatística & dados numéricos
Feminino
Seres Humanos
Masculino
Fatores de Risco
Testes Cutâneos
Estudantes/estatística & dados numéricos
Urticária/diagnóstico
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171230
[St] Status:MEDLINE


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[PMID]:27775867
[Au] Autor:Fischer J; Eberlein B; Hilger C; Eyer F; Eyerich S; Ollert M; Biedermann T
[Ad] Endereço:Department of Dermatology, Faculty of Medicine, Eberhard Karls University Tuebingen, Tuebingen, Germany.
[Ti] Título:Alpha-gal is a possible target of IgE-mediated reactivity to antivenom.
[So] Source:Allergy;72(5):764-771, 2017 May.
[Is] ISSN:1398-9995
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Antivenoms are mammalian immunoglobulins with the ability to neutralize snake venom components and to mitigate the progression of toxic effects. Immediate hypersensitivity to antivenoms often occurs during the first administration of these heterologous antibodies. A comparable clinical situation occurred after introduction of cetuximab, a chimeric mouse-human antibody, for cancer treatment. The carbohydrate epitope galactose-alpha-1,3-galactose, located on the Fab region of cetuximab, was identified as the target responsible for IgE reactivity. OBJECTIVE: To investigate whether serum IgE antibodies directed to the α-gal epitope are associated with hypersensitivity to equine antivenoms. METHODS: Antivenoms were screened for α-gal epitopes via immunoblot and in comparison with cetuximab and pork kidney by IgE reactivity assays. Basophil activation tests were used to investigate reactivity to antivenoms in samples from 20 patients with specific IgE antibodies to α-gal and 10 controls. Additional IgE detection, IgE inhibition, ImmunoCAP inhibition, and skin prick tests were performed using samples from selected patients. RESULTS: Both antivenoms and cetuximab induced positive skin prick test results in patients with sIgE to α-gal. Alpha-gal epitopes were detected by immunoblotting on antivenoms. Measurements of IgE reactivity and ImmunoCAP inhibition indicated that the antivenoms contained lower α-gal contents than cetuximab. Deglycosylation assays and IgE inhibition tests confirmed that IgE-mediated reactivity to antivenom is associated with α-gal. Antivenoms, pork kidney, and cetuximab activated basophils from patients with IgE to α-gal. CONCLUSION: Alpha-gal is a potential target of IgE-mediated reactivity to equine antivenom and a possible cause of the high incidence of hypersensitivity reactions during the first application of equine antivenom.
[Mh] Termos MeSH primário: Antivenenos/imunologia
Hipersensibilidade Imediata/imunologia
Imunoglobulina E/imunologia
alfa-Galactosidase/imunologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Animais
Basófilos/imunologia
Basófilos/metabolismo
Biomarcadores
Cetuximab/efeitos adversos
Relação Dose-Resposta Imunológica
Epitopos/imunologia
Feminino
Cavalos
Seres Humanos
Hipersensibilidade Imediata/diagnóstico
Hipersensibilidade Imediata/metabolismo
Masculino
Meia-Idade
Testes Cutâneos
Tetraspanina 30/metabolismo
Tireoglobulina/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antivenins); 0 (Biomarkers); 0 (Epitopes); 0 (Tetraspanin 30); 37341-29-0 (Immunoglobulin E); 9010-34-8 (Thyroglobulin); EC 3.2.1.22 (alpha-Galactosidase); PQX0D8J21J (Cetuximab)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171207
[Lr] Data última revisão:
171207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1111/all.13073


  5 / 30730 MEDLINE  
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[PMID]:28743423
[Au] Autor:Geng B; Eastman JJ; Mori K; Braskett M; Riedl MA
[Ad] Endereço:Division of Rheumatology, Allergy and Immunology, University of California-San Diego, La Jolla, California. Electronic address: bgeng@ucsd.edu.
[Ti] Título:Utility of minor determinants for skin testing in inpatient penicillin allergy evaluation.
[So] Source:Ann Allergy Asthma Immunol;119(3):258-261, 2017 09.
[Is] ISSN:1534-4436
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Most patients with a history of penicillin allergy can tolerate penicillin. Skin testing can identify tolerant patients, but not all known allergenic determinants are commercially available. Protocols exist that use only available reagents, but the sensitivity and safety of these protocols, particularly for hospitalized patients, are controversial. OBJECTIVE: To determine the number of hospitalized patients referred for penicillin skin testing who showed unique positivity to the minor determinants penicilloate and penilloate. METHODS: A retrospective chart review was conducted of all inpatients who underwent penicillin skin testing at 1 institution. Patients were referred by their treating physician. All patients underwent skin prick testing to benzylpenicilloyl polylysine (major determinant), penicillin G, penicilloate, penilloate (minor determinants), amoxicillin, and positive and negative controls. If the result was negative, then intradermal testing was done with the same penicillin determinants and the negative control. A 4-mm wheal with flare was considered a positive reaction. RESULTS: Inpatient penicillin skin testing was done in 528 subjects. Any positive test reaction was found in 107 subjects (20%). Three subjects (3%) reacted to penilloate only, 25 (23%) reacted to penicilloate only, 2 (2%) reacted to penicillin G only, and 8 (8%) reacted to amoxicillin only. Sixty-eight subjects (64%) reacted to a compound other than the major determinant. CONCLUSION: This study found a high rate of exclusively positive skin test reactions to the minor determinants penicilloate and penilloate. Because patients with positive test reactions are at increased risk of reaction to drug challenge, these data support the use of these reagents for penicillin skin testing in hospitalized patients.
[Mh] Termos MeSH primário: Antibacterianos/efeitos adversos
Hipersensibilidade a Drogas/diagnóstico
Penicilinas/efeitos adversos
Testes Cutâneos/utilização
[Mh] Termos MeSH secundário: Seres Humanos
Pacientes Internados
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Penicillins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171205
[Lr] Data última revisão:
171205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE


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[PMID]:29114827
[Au] Autor:Trubiano JA; Adkinson NF; Phillips EJ
[Ad] Endereço:Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia.
[Ti] Título:Persistence of Penicillin Allergy-Reply.
[So] Source:JAMA;318(17):1714-1715, 2017 11 07.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Hipersensibilidade a Drogas
Penicilinas
[Mh] Termos MeSH secundário: Seres Humanos
Testes Cutâneos
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
0 (Penicillins)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171109
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.13763


  7 / 30730 MEDLINE  
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[PMID]:29114824
[Au] Autor:Sabato V; Hagedorens M; Ebo D
[Ad] Endereço:Department of Immunology-Allergology-Rheumatology, University of Antwerp, Antwerp, Belgium.
[Ti] Título:Persistence of Penicillin Allergy.
[So] Source:JAMA;318(17):1714, 2017 11 07.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Hipersensibilidade a Drogas
Penicilinas
[Mh] Termos MeSH secundário: Seres Humanos
Testes Cutâneos
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
0 (Penicillins)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171109
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.13740


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[PMID]:28981507
[Au] Autor:Krolewiecki AJ; Almazan MC; Quipildor M; Juarez M; Gil JF; Espinosa M; Canabire M; Cajal SP
[Ad] Endereço:Instituto de Investigaciones en Enfermedades Tropicales, Universidad Nacional de Salta/CONICET, Oran, Argentina.
[Ti] Título:Reappraisal of Leishmanin Skin Test (LST) in the management of American Cutaneous Leishmaniasis: A retrospective analysis from a reference center in Argentina.
[So] Source:PLoS Negl Trop Dis;11(10):e0005980, 2017 Oct.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Leishmania (Viannia) braziliensis is the species most frequently implicated with cutaneous and mucosal leishmaniasis in the Americas; its diagnosis is based on the identification of amastigotes in lesions, which is limited by low parasite burden. Leishmanin Skin Test (LST) is a support tool for diagnosis, based on delayed type hypersensitivity responses to Leishmania antigens injected intradermally, used in endemic areas as a complement to diagnosis. A retrospective analysis of individuals evaluated for their first episode of tegumentary leishmaniasis at a reference center in Argentina during the period 2006-2015 was performed, with the goal of assessing its usefulness as a support tool in the diagnosis of leishmaniasis. Demographic, clinical and diagnostic work-up were analyzed in individuals with clinically compatible lesions, lesion`s smear and LST. A total of 733 cases that met the case definition were included in the analysis; 678 (93%) localized cutaneous cases, 50 (7%) with mucosal involvement and 5 (<1%) disseminated. Diagnostic confirmation was reached in 474 (65%) cases through positive smears from skin or mucosal lesions, with only 6 cases among this group having negative LST. Among smear negative cases, 190 were negative also by LST, but in 69 instances LST was positive. Across age groups, similar ratios of sensitivity between smear and LST were calculated. Lesions older than 21 days-old were found to correlate with positive results both for smear and LST significantly more than younger lesions. These findings support the clinical use of LST as a diagnostic complement for American Cutaneous Leishmaniasis across all age groups even in endemic areas. In this analysis, the correlation with smear was high. Standardization of this technique and further research into its most adequate preparation and utilization protocols across different sites will help in the management of suspicious clinical cases.
[Mh] Termos MeSH primário: Leishmaniose Cutânea/diagnóstico
Leishmaniose Cutânea/parasitologia
Testes Cutâneos
Pele/imunologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Antígenos de Protozoários/imunologia
Argentina/epidemiologia
Criança
Pré-Escolar
Gerenciamento Clínico
Feminino
Seres Humanos
Hipersensibilidade Tardia
Lactente
Recém-Nascido
Leishmania braziliensis/imunologia
Leishmania braziliensis/isolamento & purificação
Leishmaniose Cutânea/epidemiologia
Leishmaniose Cutânea/imunologia
Masculino
Meia-Idade
Estudos Retrospectivos
Pele/parasitologia
Pele/patologia
Adulto Jovem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Protozoan); 0 (leishmanin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171006
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005980


  9 / 30730 MEDLINE  
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Texto completo SciELO Brasil
[PMID]:28954102
[Au] Autor:Duarte I; Silveira JEPS; Hafner MFS; Toyota R; Pedroso DMM
[Ad] Endereço:Dermatology Clinic of Santa Casa de Misericórdia de São Paulo - Hospital and School of Medicine- São Paulo (SP), Brazil.
[Ti] Título:Sensitive skin: review of an ascending concept.
[So] Source:An Bras Dermatol;92(4):521-525, 2017 Jul-Aug.
[Is] ISSN:1806-4841
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Sensitive skin is a condition characterized by stinging, burning and itching sensations. The diagnosis, pathophysiology and treatment of sensitive skin are still under discussion. In the last years, studies on its epidemiology have been performed, showing a high prevalence and impact on quality of life. Brazilian population was also considered in these studies. Cosmetics, climate changes and skin barrier impairment are the main factors that contribute for skin hyperreactivity. New studies are trying to bring new knowledge about the theme. This review will describe data on epidemiology, triggering factors, pathophysiology, diagnosis and treatment.
[Mh] Termos MeSH primário: Dermatopatias
Distúrbios Somatossensoriais
[Mh] Termos MeSH secundário: Brasil/epidemiologia
Causalidade
Cosméticos/efeitos adversos
Dermatite/diagnóstico
Dermatite/epidemiologia
Dermatite/fisiopatologia
Meio Ambiente
Seres Humanos
Dermatopatias/diagnóstico
Dermatopatias/epidemiologia
Dermatopatias/etiologia
Dermatopatias/terapia
Testes Cutâneos/métodos
Distúrbios Somatossensoriais/diagnóstico
Distúrbios Somatossensoriais/epidemiologia
Distúrbios Somatossensoriais/etiologia
Distúrbios Somatossensoriais/terapia
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Cosmetics)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE


  10 / 30730 MEDLINE  
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[PMID]:28890356
[Au] Autor:Akuete K; Guffey D; Israelsen RB; Broyles JM; Higgins LJ; Green TD; Naimi DR; MacGinnitie AJ; Vitalpur G; Minard CG; Davis CM
[Ad] Endereço:Immunology, Allergy, and Rheumatology Section, Texas Children's Hospital, Houston, Texas; Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
[Ti] Título:Multicenter prevalence of anaphylaxis in clinic-based oral food challenges.
[So] Source:Ann Allergy Asthma Immunol;119(4):339-348.e1, 2017 Oct.
[Is] ISSN:1534-4436
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Although previous single-center studies report the rate of anaphylaxis for oral food challenges (OFCs) as 9% to 11%, little is known regarding the epidemiology of clinical OFCs across multiple centers in the United States. OBJECTIVE: To examine the epidemiology, symptoms, and treatment of clinical low-risk OFCs in the nonresearch setting. METHODS: Data were obtained from 2008 to 2013 through a physician survey in 5 food allergy centers geographically distributed across the United States. Allergic reaction rates and the association of reaction rates with year, hospital, and demographics were determined using a linear mixed model. Meta-analysis was used to pool the proportion of reactions and anaphylaxis with inverse-variance weights using a random-effects model with exact confidence intervals (CIs). RESULTS: A total of 6,377 OFCs were performed, and the pooled estimate of anaphylaxis was 2% (95% CI, 1%-3%). The rate of allergic reactions was 14% (95% CI, 13%-16%) and was consistent during the study period (P = .40). Reaction rates ranged from 13% to 33%. Males reacted 16% more frequently than females (95% CI, 4%-37.5%; P = .04). Foods challenged in 2013 varied geographically, with peanut as the most challenged food in the Northeast, Midwest, and West and egg as the most challenged in the South. CONCLUSION: As the largest national survey of allergic reactions of clinical open OFCs in a nonresearch setting in the United States, this study found that performing clinical nonresearch open low-risk OFCs results in few allergic reactions, with 86% of challenges resulting in no reactions and 98% without anaphylaxis.
[Mh] Termos MeSH primário: Alérgenos/imunologia
Anafilaxia/epidemiologia
Hipersensibilidade Alimentar/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Anafilaxia/diagnóstico
Anafilaxia/fisiopatologia
Arachis/química
Arachis/imunologia
Criança
Pré-Escolar
Hipersensibilidade Alimentar/diagnóstico
Hipersensibilidade Alimentar/fisiopatologia
Seres Humanos
Incidência
Lactente
Modelos Lineares
Prevalência
Risco
Fatores Sexuais
Testes Cutâneos
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Allergens)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170912
[St] Status:MEDLINE



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