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  1 / 3099 MEDLINE  
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[PMID]:28674112
[Au] Autor:Vyles D; Adams J; Chiu A; Simpson P; Nimmer M; Brousseau DC
[Ad] Endereço:Pediatric Emergency Medicine, dvyles@mcw.edu.
[Ti] Título:Allergy Testing in Children With Low-Risk Penicillin Allergy Symptoms.
[So] Source:Pediatrics;140(2), 2017 Aug.
[Is] ISSN:1098-4275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Penicillin allergy is commonly reported in the pediatric emergency department (ED). True penicillin allergy is rare, yet the diagnosis results from the denial of first-line antibiotics. We hypothesize that all children presenting to the pediatric ED with symptoms deemed to be low-risk for immunoglobulin E-mediated hypersensitivity will return negative results for true penicillin allergy. METHODS: Parents of children aged 4 to 18 years old presenting to the pediatric ED with a history of parent-reported penicillin allergy completed an allergy questionnaire. A prespecified 100 children categorized as low-risk on the basis of reported symptoms completed penicillin allergy testing by using a standard 3-tier testing process. The percent of children with negative allergy testing results was calculated with a 95% confidence interval. RESULTS: Five hundred ninety-seven parents completed the questionnaire describing their child's reported allergy symptoms. Three hundred two (51%) children had low-risk symptoms and were eligible for testing. Of those, 100 children were tested for penicillin allergy. The median (interquartile range) age at testing was 9 years (5-12). The median (interquartile range) age at allergy diagnosis was 1 year (9 months-3 years). Rash (97 [97%]) and itching (63 [63%]) were the most commonly reported allergy symptoms. Overall, 100 children (100%; 95% confidence interval 96.4%-100%) were found to have negative results for penicillin allergy and had their labeled penicillin allergy removed from their medical record. CONCLUSIONS: All children categorized as low-risk by our penicillin allergy questionnaire were found to have negative results for true penicillin allergy. The utilization of this questionnaire in the pediatric ED may facilitate increased use of first-line penicillin antibiotics.
[Mh] Termos MeSH primário: Erupção por Droga/diagnóstico
Hipersensibilidade a Drogas/diagnóstico
Serviço Hospitalar de Emergência
Testes Imunológicos/métodos
Testes Intradérmicos
Penicilinas/efeitos adversos
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Erupção por Droga/imunologia
Hipersensibilidade a Drogas/imunologia
Reações Falso-Positivas
Feminino
Seres Humanos
Imunoglobulina E/sangue
Masculino
Penicilinas/administração & dosagem
Penicilinas/imunologia
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Penicillins); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170705
[St] Status:MEDLINE


  2 / 3099 MEDLINE  
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[PMID]:28603110
[Au] Autor:Choudhary S; Murad S; Hayat MQ; Shakoor Z; Arshad M
[Ad] Endereço:Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad, Pakistan.
[Ti] Título:Identification of IgE- binding pollen protein from Cannabis sativa in pollen-hypersensitive patients from north Pakistan.
[So] Source:Pak J Pharm Sci;30(1):37-42, 2017 Jan.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:Cannabis sativa (C.sativa) is well-known for its medicinal, industrial and recreational use. However, allergies in relation to Cannabis sativa (C.sativa) are rarely reported. C. sativa is one of the common weeds found in Pakistan and its pollen grains are common in spring and fall season. Although categorized as an aeroallergen, there are limited number of reports regarding allergenic potential in C. sativa. Therefore, the current study is aimed at exploring the IgE- binding potential among the C. sativa pollen in local pollen allergic patients. Initial screening of C. sativa sensitized individuals was carried out by dot blot from the sera of pollen allergic patients. Proteins from the pollen grains were extracted and resolved on 10% gel. Eight bands were visible on gel however only one protein fragment i.e. of 14KDa size was found to bind to IgE as analyzed through protein gel blot analysis. Strong IgE affinity of a 14 kDa protein fragment from C. sativa pollen extract suggests its allergenic potential. Further study is required to find the exact nature of this protein fragment.
[Mh] Termos MeSH primário: Cannabis/efeitos adversos
Imunoglobulina E/imunologia
Proteínas de Plantas/efeitos adversos
Pólen/efeitos adversos
Rinite Alérgica Sazonal/imunologia
[Mh] Termos MeSH secundário: Biomarcadores/sangue
Western Blotting
Cannabis/imunologia
Eletroforese em Gel de Poliacrilamida
Seres Humanos
Imunoglobulina E/sangue
Testes Intradérmicos
Peso Molecular
Paquistão
Proteínas de Plantas/imunologia
Proteínas de Plantas/metabolismo
Pólen/imunologia
Pólen/metabolismo
Ligação Proteica
Rinite Alérgica Sazonal/sangue
Rinite Alérgica Sazonal/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Plant Proteins); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE


  3 / 3099 MEDLINE  
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[PMID]:28398206
[Au] Autor:Tripodi S; Pingitore G; Calvani M; Scala G; Rodriguez-Perez R; Sfika I; Asero R
[Ad] Endereço:Pediatric Department and Pediatric Allergology Unit, Sandro Pertini Hospital, Rome, Italy.
[Ti] Título:Anisakis Sensitivity in Italian Children: A Prospective Study.
[So] Source:J Investig Allergol Clin Immunol;27(2):142-143, 2017.
[Is] ISSN:1018-9068
[Cp] País de publicação:Spain
[La] Idioma:eng
[Mh] Termos MeSH primário: Anisaquíase/epidemiologia
Anisakis/imunologia
Doenças Endêmicas
Contaminação de Alimentos
Hipersensibilidade/epidemiologia
Alimentos Marinhos/parasitologia
[Mh] Termos MeSH secundário: Adolescente
Distribuição por Idade
Animais
Anisaquíase/diagnóstico
Anisaquíase/imunologia
Anisaquíase/parasitologia
Biomarcadores/sangue
Criança
Pré-Escolar
Feminino
Seres Humanos
Hipersensibilidade/diagnóstico
Hipersensibilidade/imunologia
Hipersensibilidade/parasitologia
Imunoglobulina E/sangue
Lactente
Testes Intradérmicos
Itália
Masculino
Valor Preditivo dos Testes
Prevalência
Estudos Prospectivos
Fatores de Risco
Testes Sorológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Biomarkers); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.18176/jiaci.0139


  4 / 3099 MEDLINE  
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[PMID]:28398203
[Au] Autor:Gonzalez-Cavero L; Dominguez-Ortega J; Gonzalez-Muñoz M; Mayor-Ibarguren A; Tomás M; Fiandor A; Quirce S
[Ad] Endereço:Department of Allergy, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.
[Ti] Título:Delayed Allergic Reaction to Terbinafine With a Positive Lymphocyte Transformation Test.
[So] Source:J Investig Allergol Clin Immunol;27(2):136-137, 2017.
[Is] ISSN:1018-9068
[Cp] País de publicação:Spain
[La] Idioma:eng
[Mh] Termos MeSH primário: Antifúngicos/efeitos adversos
Proliferação Celular/efeitos dos fármacos
Hipersensibilidade a Drogas/etiologia
Hipersensibilidade Tardia/induzido quimicamente
Ativação Linfocitária/efeitos dos fármacos
Linfócitos/efeitos dos fármacos
Naftalenos/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Células Cultivadas
Hipersensibilidade a Drogas/diagnóstico
Hipersensibilidade a Drogas/imunologia
Feminino
Seres Humanos
Hipersensibilidade Tardia/diagnóstico
Hipersensibilidade Tardia/imunologia
Testes Intradérmicos
Linfócitos/imunologia
Testes do Emplastro
Valor Preditivo dos Testes
Fatores de Tempo
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Naphthalenes); G7RIW8S0XP (terbinafine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.18176/jiaci.0133


  5 / 3099 MEDLINE  
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[PMID]:28382604
[Au] Autor:Romano A; Valluzzi RL; Caruso C; Maggioletti M; Gaeta F
[Ad] Endereço:Allergy Unit, Presidio Columbus, Via G. Moscati, 31, 00168, Rome, Italy. aromano.allergy@gmail.com.
[Ti] Título:Non-immediate Cutaneous Reactions to Beta-Lactams: Approach to Diagnosis.
[So] Source:Curr Allergy Asthma Rep;17(4):23, 2017 Apr.
[Is] ISSN:1534-6315
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Non-immediate cutaneous reactions (i.e., occurring at least 1 h after the initial drug administration), particularly maculopapular exanthemas and urticarial eruptions, are common during beta-lactam treatments. A T cell-mediated pathogenic mechanism has been demonstrated in some cutaneous reactions, such as maculopapular exanthema, fixed drug eruption, acute generalized exanthematous pustulosis, and drug-induced hypersensitivity syndrome. In the diagnostic work-up, patch testing is useful, together with delayed-reading intradermal testing. Patch tests are a simple and safe diagnostic tool, which in the case of severe reactions should be used as the first line of investigation. However, patch tests are less sensitive than intradermal tests, which are preferable in subjects with mild reactions. Lymphocyte transformation or activation tests and enzyme-linked immunosorbent spot assays can be used as complementary tests. In selected cases of mild or moderate reactions, displaying negative results in the aforesaid allergy tests, a graded challenge with the implicated beta-lactam can be performed.
[Mh] Termos MeSH primário: Antibacterianos/efeitos adversos
Hipersensibilidade a Drogas/diagnóstico
Hipersensibilidade Tardia/diagnóstico
Testes Cutâneos/métodos
beta-Lactamas/efeitos adversos
[Mh] Termos MeSH secundário: Hipersensibilidade a Drogas/imunologia
Seres Humanos
Testes Intradérmicos
Ativação Linfocitária
Uso Excessivo de Produtos e Serviços de Saúde
Urticária/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (beta-Lactams)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.1007/s11882-017-0691-4


  6 / 3099 MEDLINE  
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[PMID]:28294591
[Au] Autor:Liccardi G; Calzetta L; Salzillo A; Billeri L; Lucà G; Rogliani P
[Ad] Endereço:Department of Pulmonology, Haematology and Oncology, Division of Pulmonology and Allergology, High Speciality "A. Cardarelli" Hospital, Naples, Italy. Postgraduate School of Respiratory Medicine, Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy. Phone: +39 081 747 3335-6
[Ti] Título:Letter to the Editor: Can dog allergen immunotherapy reduce concomitant allergic sensitization to other furry animals? A preliminary experience.
[So] Source:Eur Ann Allergy Clin Immunol;49(2):92-96, 2017 03.
[Is] ISSN:1764-1489
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Summary: It has been shown that allergen immunotherapy (AIT) is effective in reducing symptoms of allergic asthma and rhinitis. Data on the efficacy are less convincing with regard to AIT for allergens of common pets (cats/dogs). We describe a case of dog allergy in which we explored if dog AIT (DAI) could reduce a concomitant allergic sensitization to other allergens of furry animals. Our case demonstrates the efficacy of sublingual DAI on SPTs, symptom score, and spirometric responses despite persistent exposure to dog allergens at home in a patient sensitized, but not exposed, to several other furry animals. Moreover, this is the first report suggesting that DAI is able to reduce SPTs responses not only to dog, but also to other furry animals such as rabbit, horse, mouse, rat, hamster, cow. We recommend an accurate anamnesis and diagnosis of dog allergy before prescribing DAI. In particular, the use of ImmunoCAP ISAC is essential to verify the presence of IgE to lipocalins / albumins belonging to other furry animals. Obviously further studies carried out by using different DAI schedules, allergen amount and time of re-evaluation, laboratory procedure should be performed to confirm our findings.
[Mh] Termos MeSH primário: Alérgenos/administração & dosagem
Asma/terapia
Cães/imunologia
Cabelo/imunologia
Imunoterapia Sublingual/métodos
[Mh] Termos MeSH secundário: Administração Sublingual
Adulto
Albuminas/imunologia
Alérgenos/imunologia
Animais
Asma/diagnóstico
Asma/imunologia
Biomarcadores/sangue
Seres Humanos
Imunoglobulina E/sangue
Testes Intradérmicos
Lipocalinas/imunologia
Masculino
Especificidade da Espécie
Espirometria
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
0 (Albumins); 0 (Allergens); 0 (Biomarkers); 0 (Lipocalins); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE


  7 / 3099 MEDLINE  
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[PMID]:28294589
[Au] Autor:Almeida JP; Lopes A; Campos Melo A; Pereira Santos MC; Pereira Barbosa M
[Ad] Endereço:Department of Immunoallergology, Santa Maria Hospital, Lisbon, Portugal Unit of Clinical Immunology, Institute of Molecular Medicine, Faculty of Medicine of Lisbon, Portugal. E-mail: jpedro.gla@gmail.com.
[Ti] Título:Selective hypersensitivity to cefazolin and contribution of the basophil activation test.
[So] Source:Eur Ann Allergy Clin Immunol;49(2):84-87, 2017 Mar.
[Is] ISSN:1764-1489
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Summary: The authors present 2 case reports of selective cefazolin hypersensitivity: a 49 year-old woman with a history of two perioperative reactions (urticaria and severe anaphylaxis) after the use of rocuronium, propophol and cefazolin; a 36 year-old pregnant woman who developed facial erythema, lips angioedema and hypotension immediately after administration of ropivacain, sufentanil, cefazolin, oxytocin and ephedrine. In both cases, intradermal skin tests were positive for cefazolin. A basophil activation test was performed for cefazolin, which was positive in one patient. Oral challenge tests with penicillin, amoxicillin and other cephalosporins were negative. This selective hypersensitivity to cefazolin may be associated with a R1-side chain different from other beta-lactams.
[Mh] Termos MeSH primário: Anafilaxia/induzido quimicamente
Antibacterianos/efeitos adversos
Teste de Degranulação Basófila
Basófilos/efeitos dos fármacos
Cefazolina/efeitos adversos
Hipersensibilidade a Drogas/etiologia
Urticária/induzido quimicamente
[Mh] Termos MeSH secundário: Adulto
Anafilaxia/diagnóstico
Anafilaxia/imunologia
Antibacterianos/imunologia
Basófilos/imunologia
Cefazolina/imunologia
Hipersensibilidade a Drogas/diagnóstico
Hipersensibilidade a Drogas/imunologia
Feminino
Seres Humanos
Testes Intradérmicos
Meia-Idade
Valor Preditivo dos Testes
Gravidez
Urticária/diagnóstico
Urticária/imunologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); IHS69L0Y4T (Cefazolin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE


  8 / 3099 MEDLINE  
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[PMID]:28294588
[Au] Autor:Ciprandi G; Comite P; Ferrero F; Montaruli R; Mussap M
[Ad] Endereço:Internal Medicine Department, IRCCS-AOU San Martino - IST, Largo R. Benzi 10, 16132 Genoa, Italy. E-mail: gio.cip@libero.it.
[Ti] Título:Prescriptive appropriateness using inhalant and food allergen panels: a comparison between General Practitioners' and Allergists' prescription in Genoa (Italy).
[So] Source:Eur Ann Allergy Clin Immunol;49(2):80-83, 2017 Mar.
[Is] ISSN:1764-1489
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Summary: Prescriptive appropriateness is an actual claim in healthcare, and it also concerns in vitro tests used in the allergy work-up, such as the serum allergen-specific IgE (sIgE) assay. In the Liguria Region, two panels were defined (for inhaled and food allergens) including 12 allergens. Their composition changed over time. The aims of the present retrospective study were: i) to evaluate the percentage of positive tests, and ii) to compare the findings of sIgE assay on the basis of the general practictioners' (GPs) or specialist' prescription, considering both the old panels and the new panels. This retrospective study considered a population of adult patients, which consisted of 2368 subjects (68% females; mean age 50 years; age range: 10-103 years). Serum sIgE were measured by ImmunoCap system. The percentages of positive tests were very low for food allergens and low for inhaled ones (ranging between 5% to 35%). There was change of prevalent prescriptor with new panels. This study underlines the relevance of prescriptive appropriateness in the allergy work-up. The sIgE assay should be limited to those allergens that have a clinical relevance, based on clinical history.
[Mh] Termos MeSH primário: Alérgenos/administração & dosagem
Alergistas/tendências
Hipersensibilidade Alimentar/diagnóstico
Clínicos Gerais/tendências
Imunoglobulina E/sangue
Exposição por Inalação
Testes Intradérmicos/tendências
Padrões de Prática Médica/tendências
Hipersensibilidade Respiratória/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Alérgenos/imunologia
Biomarcadores/sangue
Criança
Prescrições de Medicamentos
Feminino
Hipersensibilidade Alimentar/sangue
Hipersensibilidade Alimentar/imunologia
Seres Humanos
Itália
Masculino
Meia-Idade
Valor Preditivo dos Testes
Hipersensibilidade Respiratória/sangue
Hipersensibilidade Respiratória/imunologia
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Biomarkers); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE


  9 / 3099 MEDLINE  
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[PMID]:28294587
[Au] Autor:Lombardi C; Passalacqua G; Italian Vitamin D Allergy Group
[Ad] Endereço:Departmental Unit of Allergology, Clinical Immunology & Pneumology, Fondazione Poliambulanza Hospital, Brescia, Italy.
[Ti] Título:Vitamin D levels and allergic diseases. An italian cross-sectional multicenter survey.
[So] Source:Eur Ann Allergy Clin Immunol;49(2):75-79, 2017 Mar.
[Is] ISSN:1764-1489
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Summary: During the two last decades, the interest in the role of Vitamin D (VD) in allergic disease has increased. Apart from the well-known actions of VD in bone metabolism, recent studies suggested its possible role as an immune-modulator in allergy. This study, conducted over the Italian territory, evaluated the possible correlations between VD serum level and diagnosed allergic diseases (rhinitis / asthma, food allergy, atopic dermatitis). Thus, VD was assessed in patients with physician-diagnosed allergic diseases. The study was carried out in hospital- and private practice-based setting between October 2012 and March 2013, and 18 Centers participated. Only adult patients, with at least one positive skin prick test were included. The diagnostic procedures and the data collection were standardized among the centers. VD levels were assayed by the same laboratory test. Three hundred and nine patients were enrolled (132 male, mean age 37.5 ± 17 years). Of them, 40% reported a positive family history for allergies (asthma / rhinitis). Rhinitis plus asthma was present in 47% of patients, atopic dermatitis in 15%, and a consistent clinical history of food allergy associated with positive skin tests was present in 25% of subjects. There was no significant association between VD level and age, sex, family history, rhinitis, or food allergy. VD levels were overall lower in patients with asthma and rhinitis, but without statistical significance. A significant difference in VD levels was detected between patient with or without atopic dermatitis. VD was not related to seasonal allergens, whereas a significant negative correlation was seen for house dust mite and dog dander. Our data, derived from a cross-sectional study involving only allergic patients, agree partially with the current literature. Nonetheless, the association between VD levels and allergies appeared weak. Studies involving larger samples would be required to better define the association between VD and allergies.
[Mh] Termos MeSH primário: Hipersensibilidade/epidemiologia
Deficiência de Vitamina D/epidemiologia
Vitamina D/análogos & derivados
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Asma/diagnóstico
Asma/epidemiologia
Biomarcadores/sangue
Estudos Transversais
Dermatite Atópica/diagnóstico
Dermatite Atópica/epidemiologia
Feminino
Hipersensibilidade Alimentar/diagnóstico
Hipersensibilidade Alimentar/epidemiologia
Seres Humanos
Hipersensibilidade/sangue
Hipersensibilidade/diagnóstico
Testes Intradérmicos
Itália/epidemiologia
Masculino
Meia-Idade
Rinite Alérgica/diagnóstico
Rinite Alérgica/epidemiologia
Vitamina D/sangue
Deficiência de Vitamina D/sangue
Deficiência de Vitamina D/diagnóstico
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Biomarkers); 1406-16-2 (Vitamin D); 64719-49-9 (25-hydroxyvitamin D)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE


  10 / 3099 MEDLINE  
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[PMID]:28261917
[Au] Autor:Olivry T; Dunston SM; Favrot C; Prélaud P; Tsukui T
[Ad] Endereço:Department of Clinical Sciences, College of Veterinary Medicine, NC State University, 1060 William Moore Drive, Raleigh, NC, 27607, USA.
[Ti] Título:The novel high molecular weight Dermatophagoides farinae protein Zen-1 is a major allergen in North American and European mite allergic dogs with atopic dermatitis.
[So] Source:Vet Dermatol;28(2):177-e38, 2017 Apr.
[Is] ISSN:1365-3164
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Atopic dogs with hypersensitivity to Dermatophagoides farinae (Df) have IgE recognizing high molecular weight (MW) allergens more often than the low MW Der f 1 and 2. A new high MW Df allergen, Zen-1, has been identified recently. OBJECTIVES: To determine the IgE reactivity of American and European Df-hypersensitive dogs to Zen-1, Der f 1 and Der f 2. METHODS: We tested sera from 33 Df-reactive dogs from the USA, 29 from Europe and 15 experimentally sensitized to Df, by ELISA against crude Df, Der f 1, Der f 2 and Zen-1. ELISA inhibition was performed with sera reactive to Zen-1. Intradermal testing (IDT) was also done with the same allergens in 25 other American atopic dogs. RESULTS: Altogether, IgE seropositivity to Zen-1 was more prevalent (86%) than that to Der f 1 (17%) or Der f 2 (19%). The IgE reactivity to Zen-1 was correlated to that against crude Df; this allergen alone inhibited a high percentage (median: 50%; range: 22-84%) of the binding to the crude mite extract. The seropositivity to low MW allergens was highest in experimentally sensitized dogs. Serum IgE recognition of Der f 1 was low in dogs with AD; that to Der f 2 was significantly lower in American dogs (6%) than in European ones (28%). A high prevalence of positive immediate IDT reactions to Zen-1 confirmed the likely relevance of serological results. CONCLUSIONS AND CLINICAL IMPORTANCE: This study establishes Zen-1 as a major allergen in atopic dogs sensitized to Df.
[Mh] Termos MeSH primário: Antígenos de Dermatophagoides/imunologia
Dermatite Atópica/veterinária
Doenças do Cão/imunologia
Imunoglobulina E/imunologia
Proteínas de Insetos/imunologia
[Mh] Termos MeSH secundário: Animais
Especificidade de Anticorpos
Dermatite Atópica/epidemiologia
Dermatite Atópica/imunologia
Doenças do Cão/epidemiologia
Cães
Ensaio de Imunoadsorção Enzimática/veterinária
Europa (Continente)/epidemiologia
Imunoglobulina E/sangue
Testes Intradérmicos/veterinária
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Dermatophagoides); 0 (Insect Proteins); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170307
[St] Status:MEDLINE
[do] DOI:10.1111/vde.12393



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