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[PMID]:28461147
[Au] Autor:Diel R; Ringshausen F; Richter E; Welker L; Schmitz J; Nienhaus A
[Ad] Endereço:Institute for Epidemiology, University Medical Hospital Schleswig-Holstein, Kiel. Member of the German Center for Lung Research (ARCN); Airway Research Center North (ARCN), German Center for Lung Research (DZL) LungClinic Grosshansdorf. Electronic address: roland.diel@epi.uni-kiel.de.
[Ti] Título:Microbiological and Clinical Outcomes of Treating Non-Mycobacterium Avium Complex Nontuberculous Mycobacterial Pulmonary Disease: A Systematic Review and Meta-Analysis.
[So] Source:Chest;152(1):120-142, 2017 07.
[Is] ISSN:1931-3543
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Pulmonary disease caused by nontuberculous mycobacteria (NTM) is steadily increasing worldwide. METHODS: A systematic review of non-Mycobacterium avium complex studies published prior to October 2016 was conducted with respect to microbiological and clinical outcomes of current treatment regimens. RESULTS: We retrieved 352 citations, which yielded 24 studies eligible for evaluation. Sixteen studies were retrospective chart reviews, three studies were prospective, and only five studies were randomized. The weighted average proportion of sputum culture conversion (SCC) after subtracting posttreatment relapses for patients with M abscessus was 41.2% (95% CI, 28.6%-54.5%) but was 69.8% (95% CI, 41.0%-91.9%) with subspecies M massiliense in macrolide-containing regimens, 80.2% (95% CI, 58.4%-95.2%) in patients with M kansasii, 32.0% (95% CI, 16.5%-49.8%) for M xenopi (MX) and 54.4% (95% CI, 34.7%-73.4%) for M malmoense. SCCs in the total of 55 patients who underwent lung resection and had MX or M abscessus was high at 75.9%. The risk of bias was low in four of five randomized studies. However, heterogeneous use of outcome parameters (eight definitions of "relapse," eight of "treatment success," and four of "cure") hampered comparison of nonrandomized studies as well as producing possible bias by a posteriori exclusion (13.3%) and uncompleted treatment of participants (25.3%). CONCLUSIONS: As a sustained microbiological response without surgery is unsatisfactory in treating M abscessus, MX, and M malmoense, functional and quality of life aspects should be given more emphasis in the individual evaluation of treatment outcome. Further, properly planned studies with sufficient power are needed, as are new drugs or better-tolerated application of current antibiotics, or both.
[Mh] Termos MeSH primário: Pneumopatias
Infecções por Micobactéria não Tuberculosa
Complexo Mycobacterium avium
Micobactérias não Tuberculosas
[Mh] Termos MeSH secundário: Ensaios Clínicos como Assunto
Gerenciamento Clínico
Seres Humanos
Pneumopatias/diagnóstico
Pneumopatias/microbiologia
Pneumopatias/terapia
Técnicas Microbiológicas/métodos
Infecções por Micobactéria não Tuberculosa/diagnóstico
Infecções por Micobactéria não Tuberculosa/microbiologia
Infecções por Micobactéria não Tuberculosa/terapia
Complexo Mycobacterium avium/efeitos dos fármacos
Complexo Mycobacterium avium/isolamento & purificação
Complexo Mycobacterium avium/patogenicidade
Micobactérias não Tuberculosas/efeitos dos fármacos
Micobactérias não Tuberculosas/isolamento & purificação
Micobactérias não Tuberculosas/patogenicidade
Avaliação de Processos e Resultados (Cuidados de Saúde)
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:29430908
[Au] Autor:Aleshnya VV; Zhuravlev PV; Panasovets OP
[Ti] Título:[study in the experimental conditions of pesticide action on microorganisms characterizing sanitary-epidemiological safety of reservoirs].
[So] Source:Gig Sanit;95(8):785-9, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The paper presents experimental data on the pesticides action (molinate (OrdramA), Dinitroortocresolum and chlorophos) at concentrations of 0.01 mg /l to 10 mg/l on sanitary-indicative (TBC, total coliform bacteria, E. coli, E. faecalis), potentially pathogenic ( Ps. aeruginosa) and pathogenic (S. Derby) microflora of the river water. As the test cultures there were used isolated from the reservoir and museum strains of microorganisms. Due to the fact that the rate of decomposition ofpesticides in water increases in direct proportion to the extent of its biological contamination, the experiments were performed with the river water: native and sterilized by autoclaving. There were identified species and strain differences in the microbial response to the action of pesticides. The selectivity of OrdramA action at a concentration of 0.1 to 10 mg/l on Salmonella and of chlorophos at a concentration of 10 mg/l for Salmonella and E. coli is manifested in the stimulation of the reproduction of these bacteria. Dinitroortocresolum in concentrations of 10 mg/l and 1 mg/l gives rise in the reproduction of Pseudomonas aeruginosa and inhibits the growth of total coliform bacteria and E. coli, in a concentration of 0.1 mg/l the preparation stimulates the viability of all the studied microorganisms. When entering the body of water, pesticides were found to cause changes of biocenosis in the river water and disturb bacterial self-cleaning processes. In conditions of pesticide pollution total coliform bacteria, E. coli and E. faecalis unable to maintain their indicative value and therefore the use of only them for the evaluation of the sanitary-epidemiological status of the water source appears to be insufficient. Due to the fact that the epidemic potential of water is directly dependent on quantitative content ofpathogenic and opportunistic pathogenic microorganisms in it, the reproduction Salmonella and Pseudomonas bacteria is a negative moment from the sanitary and epidemiological point of view.
[Mh] Termos MeSH primário: Bactérias
Monitoramento Ambiental
Água Doce
Consórcios Microbianos/efeitos dos fármacos
Praguicidas/farmacologia
Microbiologia da Água/normas
[Mh] Termos MeSH secundário: Bactérias/classificação
Bactérias/efeitos dos fármacos
Bactérias/isolamento & purificação
Ecossistema
Monitoramento Ambiental/métodos
Monitoramento Ambiental/normas
Água Doce/análise
Água Doce/microbiologia
Seres Humanos
Técnicas Microbiológicas
Federação Russa/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pesticides)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE


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[PMID]:27776997
[Au] Autor:Alonso B; Lucio J; Pérez-Granda MJ; Cruces R; Sánchez-Carrillo C; Bouza E; Guembe M
[Ad] Endereço:Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
[Ti] Título:Does biomass production correlate with metabolic activity in Staphylococcus aureus?
[So] Source:J Microbiol Methods;131:110-112, 2016 12.
[Is] ISSN:1872-8359
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:We assessed agreement between the crystal violet binding assay and the XTT assay in the classification of biofilm production in 492 Staphylococcus aureus strains from bacteremic patients. We found that the overall correlation between the procedures was 46.5%. Biomass production and metabolic activity must be assessed simultaneously.
[Mh] Termos MeSH primário: Biomassa
Staphylococcus aureus/crescimento & desenvolvimento
Staphylococcus aureus/metabolismo
[Mh] Termos MeSH secundário: Biofilmes/crescimento & desenvolvimento
Violeta de Genciana/análise
Seres Humanos
Metaboloma
Técnicas Microbiológicas/métodos
Coloração e Rotulagem/métodos
Infecções Estafilocócicas/microbiologia
Staphylococcus aureus/patogenicidade
Staphylococcus aureus/fisiologia
Sais de Tetrazólio/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Tetrazolium Salts); J4Z741D6O5 (Gentian Violet)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180126
[Lr] Data última revisão:
180126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


  4 / 6017 MEDLINE  
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[PMID]:27770851
[Au] Autor:Doern CD; Butler-Wu SM
[Ad] Endereço:Association for Molecular Pathology's Matrix-Assisted Laser Desorption Ionization Time-of-Flight Working Group, Bethesda, Maryland; Department of Pathology, Virginia Commonwealth University Medical Center, Richmond, Virginia. Electronic address: cdoern@mcvh-vcu.edu.
[Ti] Título:Emerging and Future Applications of Matrix-Assisted Laser Desorption Ionization Time-of-Flight (MALDI-TOF) Mass Spectrometry in the Clinical Microbiology Laboratory: A Report of the Association for Molecular Pathology.
[So] Source:J Mol Diagn;18(6):789-802, 2016 11.
[Is] ISSN:1943-7811
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The performance of matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MS) for routine bacterial and yeast identification as well as direct-from-blood culture bottle identification has been thoroughly evaluated in the peer-reviewed literature. Microbiologists are now moving beyond these methods to apply MS to other areas of the diagnostic process. This review discusses the emergence of advanced matrix-assisted laser desorption ionization time-of-flight MS applications, including the identification of filamentous fungi and mycobacteria and the current and future state of antimicrobial resistance testing.
[Mh] Termos MeSH primário: Serviços de Laboratório Clínico
Técnicas Microbiológicas
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz/métodos
[Mh] Termos MeSH secundário: Bactérias/química
Bactérias/classificação
Serviços de Laboratório Clínico/tendências
Resistência Microbiana a Medicamentos
Seres Humanos
Infecção/diagnóstico
Infecção/microbiologia
Testes de Sensibilidade Microbiana
Técnicas Microbiológicas/métodos
Técnicas Microbiológicas/tendências
Leveduras/química
Leveduras/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  5 / 6017 MEDLINE  
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[PMID]:28746261
[Au] Autor:McAuliffe GN; Taylor SL; Drinkovic D; Roberts SA; Wilson EM; Best EJ
[Ad] Endereço:From the *Microbiology Department, Auckland City Hospital, †Microbiology Department, Middlemore Hospital, ‡Microbiology Department, North Shore Hospital, and §Department of Paediatric Infectious Diseases, Starship Children's Hospital, Auckland, New Zealand.
[Ti] Título:Rotavirus Infection in the Auckland Region After the Implementation of Universal Infant Rotavirus Vaccination: Impact on Hospitalizations and Laboratory Implications.
[So] Source:Pediatr Infect Dis J;37(1):e1-e5, 2018 Jan.
[Is] ISSN:1532-0987
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In July 2014, New Zealand introduced universal infant vaccination with RotaTeq (Merk & Co.) administered as 3 doses at 6 weeks, 3 and 5 months of age. We sought to assess the impact of rotavirus vaccination on gastroenteritis (GE) hospitalizations in the greater Auckland region and analyze changes in rotavirus testing in the period around vaccine introduction. METHODS: Hospitalizations, laboratory testing rates and methods were compared between the pre-vaccine period (2009-2013), post-vaccine period (January 2015 to December 2015) and year of vaccine introduction (2014). RESULTS: There was a 68% decline in rotavirus hospitalizations of children <5 years of age after vaccine introduction (from 258/100,000 to 83/100,000) and a 17% decline in all-cause gastroenteritis admissions (from 1815/100,000 to 1293/100,000). Reductions were also seen in pediatric groups too old to have received vaccine. Despite these changes, rotavirus testing rates in our region remained static in the year after vaccine introduction compared with the 2 prior years, and after vaccine introduction, we observed a high rate of false positives 19/58 (33%) in patients with reactive rotavirus tests. CONCLUSIONS: Rotavirus vaccine has had a significant early impact on gastroenteritis hospitalizations for children in the Auckland region. However, continued rotavirus testing at pre-vaccine rates risks generating false positive results. Laboratories and clinicians should consider reviewing their testing algorithms before vaccine introduction.
[Mh] Termos MeSH primário: Gastroenterite/epidemiologia
Hospitalização/estatística & dados numéricos
Técnicas Microbiológicas/estatística & dados numéricos
Infecções por Rotavirus/epidemiologia
Vacinas contra Rotavirus
Vacinação/estatística & dados numéricos
[Mh] Termos MeSH secundário: Pré-Escolar
Reações Falso-Positivas
Gastroenterite/prevenção & controle
Gastroenterite/virologia
Seres Humanos
Lactente
Recém-Nascido
Técnicas Microbiológicas/utilização
Nova Zelândia/epidemiologia
Rotavirus
Infecções por Rotavirus/prevenção & controle
Infecções por Rotavirus/virologia
Vacinas Atenuadas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RotaTeq); 0 (Rotavirus Vaccines); 0 (Vaccines, Attenuated)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180110
[Lr] Data última revisão:
180110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1097/INF.0000000000001706


  6 / 6017 MEDLINE  
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[PMID]:29048594
[Au] Autor:Marinier E; Zaheer R; Berry C; Weedmark KA; Domaratzki M; Mabon P; Knox NC; Reimer AR; Graham MR; Chui L; Patterson-Fortin L; Zhang J; Pagotto F; Farber J; Mahony J; Seyer K; Bekal S; Tremblay C; Isaac-Renton J; Prystajecky N; Chen J; Slade P; Van Domselaar G
[Ad] Endereço:National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington St, Winnipeg, MB R3E 3R2, Canada.
[Ti] Título:Neptune: a bioinformatics tool for rapid discovery of genomic variation in bacterial populations.
[So] Source:Nucleic Acids Res;45(18):e159, 2017 Oct 13.
[Is] ISSN:1362-4962
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The ready availability of vast amounts of genomic sequence data has created the need to rethink comparative genomics algorithms using 'big data' approaches. Neptune is an efficient system for rapidly locating differentially abundant genomic content in bacterial populations using an exact k-mer matching strategy, while accommodating k-mer mismatches. Neptune's loci discovery process identifies sequences that are sufficiently common to a group of target sequences and sufficiently absent from non-targets using probabilistic models. Neptune uses parallel computing to efficiently identify and extract these loci from draft genome assemblies without requiring multiple sequence alignments or other computationally expensive comparative sequence analyses. Tests on simulated and real datasets showed that Neptune rapidly identifies regions that are both sensitive and specific. We demonstrate that this system can identify trait-specific loci from different bacterial lineages. Neptune is broadly applicable for comparative bacterial analyses, yet will particularly benefit pathogenomic applications, owing to efficient and sensitive discovery of differentially abundant genomic loci. The software is available for download at: http://github.com/phac-nml/neptune.
[Mh] Termos MeSH primário: Bactérias/genética
Biologia Computacional/métodos
Análise Mutacional de DNA/métodos
Estudos de Associação Genética
Técnicas Microbiológicas/métodos
Análise de Sequência de DNA/métodos
Software
[Mh] Termos MeSH secundário: Bacillus anthracis/genética
Regulação Bacteriana da Expressão Gênica
Genoma Bacteriano
Transcriptoma
Vibrio cholerae/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1093/nar/gkx702


  7 / 6017 MEDLINE  
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[PMID]:29035494
[Au] Autor:Food and Drug Administration, HHS
[Ti] Título:Medical Devices; Immunology and Microbiology Devices; Classification of the Automated Image Assessment System for Microbial Colonies on Solid Culture Media. Final order.
[So] Source:Fed Regist;82(198):47967-9, 2017 Oct 16.
[Is] ISSN:0097-6326
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Food and Drug Administration (FDA or we) is classifying the automated image assessment system for microbial colonies on solid culture media into class II (special controls). The special controls that apply to the device type are identified in this order and will be part of the codified language for the automated image assessment system for microbial colonies on solid culture media's classification. We are taking this action because we have determined that classifying the device into class II (special controls) will provide a reasonable assurance of safety and effectiveness of the device. We believe this action will also enhance patients' access to beneficial innovative devices, in part by reducing regulatory burdens.
[Mh] Termos MeSH primário: Aprovação de Equipamentos/legislação & jurisprudência
Segurança de Equipamentos/classificação
Processamento de Imagem Assistida por Computador/classificação
Processamento de Imagem Assistida por Computador/instrumentação
Técnicas Microbiológicas/classificação
Técnicas Microbiológicas/instrumentação
[Mh] Termos MeSH secundário: Meios de Cultura
Seres Humanos
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Culture Media)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:T
[Da] Data de entrada para processamento:171017
[St] Status:MEDLINE


  8 / 6017 MEDLINE  
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[PMID]:28951606
[Au] Autor:Thao NB; Kitani S; Nitta H; Tomioka T; Nihira T
[Ad] Endereço:International Center for Biotechnology, Osaka University, Osaka, Japan.
[Ti] Título:Discovering potential Streptomyces hormone producers by using disruptants of essential biosynthetic genes as indicator strains.
[So] Source:J Antibiot (Tokyo);70(10):1004-1008, 2017 Oct.
[Is] ISSN:0021-8820
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Autoregulators are low-molecular-weight signaling compounds that control the production of many secondary metabolites in actinomycetes and have been referred to as 'Streptomyces hormones'. Here, potential producers of Streptomyces hormones were investigated in 40 Streptomyces and 11 endophytic actinomycetes. Production of γ-butyrolactone-type (IM-2, VB) and butenolide-type (avenolide) Streptomyces hormones was screened using Streptomyces lavendulae FRI-5 (ΔfarX), Streptomyces virginiae (ΔbarX) and Streptomyces avermitilis (Δaco), respectively. In these strains, essential biosynthetic genes for Streptomyces hormones were disrupted, enabling them to respond solely to the externally added hormones. The results showed that 20% of each of the investigated strains produced IM-2 and VB, confirming that γ-butyrolactone-type Streptomyces hormones are the most common in actinomycetes. Unlike the γ-butyrolactone type, butenolide-type Streptomyces hormones have been discovered in recent years, but their distribution has been unclear. Our finding that 24% of actinomycetes (12 of 51 strains) showed avenolide activity revealed for the first time that the butenolide-type Streptomyces hormone is also common in actinomycetes.
[Mh] Termos MeSH primário: Técnicas de Inativação de Genes
Redes e Vias Metabólicas/genética
Feromônios/metabolismo
Streptomyces/metabolismo
[Mh] Termos MeSH secundário: Programas de Rastreamento
Técnicas Microbiológicas
Feromônios/química
Feromônios/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pheromones)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE
[do] DOI:10.1038/ja.2017.85


  9 / 6017 MEDLINE  
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[PMID]:28877199
[Au] Autor:Gunda NSK; Dasgupta S; Mitra SK
[Ad] Endereço:Micro & Nano-scale Transport Laboratory, Lassonde School of Engineering, York University, Toronto, M3J 1P3, Ontario, Canada.
[Ti] Título:DipTest: A litmus test for E. coli detection in water.
[So] Source:PLoS One;12(9):e0183234, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We have developed a new litmus paper test (DipTest) for detecting Escherichia coli (E. coli) in water samples by performing enzymatic reactions directly on the porous paper substrate. The paper strip consists of a long narrow piece of cellulose blotting paper coated with chemoattractant (at bottom edge), wax hydrophobic barrier (at the top edge), and custom formulated chemical reagents (at reaction zone immediately below the wax hydrophobic barrier). When the paper strip is dipped in water, E. coli in the water sample is attracted toward the paper strip due to a chemotaxic mechanism followed by the ascent along the paper strip toward the reaction zone due to a capillary wicking mechanism, and finally the capillary motion is arrested at the top edge of the paper strip by the hydrophobic barrier. The E. coli concentrated at the reaction zone of the paper strip will react with custom formulated chemical reagents to produce a pinkish-red color. Such a color change on the paper strip when dipped into water samples indicates the presence of E. coli contamination in potable water. The performance of the DipTest device has been checked with different known concentrations of E. coli contaminated water samples using different dip and wait times. The DipTest device has also been tested with different interfering bacteria and chemical contaminants. It has been observed that the different interfering contaminants do not have any impact on the DipTest, and it can become a potential solution for screening water samples for E. coli contamination at the point of source.
[Mh] Termos MeSH primário: Escherichia coli/isolamento & purificação
Técnicas Microbiológicas/métodos
Papel
Microbiologia da Água
[Mh] Termos MeSH secundário: Cor
Meios de Cultura
Escherichia coli/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Culture Media)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183234


  10 / 6017 MEDLINE  
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[PMID]:28739646
[Au] Autor:Rathi VM; Thakur M; Sharma S; Khanna R; Garg P
[Ad] Endereço:Tej Kohli Cornea Institute, L V Prasad Eye Institute, Hyderabad, India.
[Ti] Título:KOH mount as an aid in the management of infectious keratitis at secondary eye care centre.
[So] Source:Br J Ophthalmol;101(11):1447-1450, 2017 Nov.
[Is] ISSN:1468-2079
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: To report the clinical outcome of infectious keratitis managed after doing 10% KOH mount of corneal smears and reporting done by an ophthalmologist in the secondary eye care centre in South India. METHODS: 103 consecutive cases of microbial keratitis were studied. Inclusion criteria were presence of corneal infiltrate on slit lamp biomicroscopy. An ophthalmologist carried out microbiological evaluation of 10% KOH mount of corneal scrapings. No cultures were done at secondary centres. Antifungal therapy with 5% Natamycin was initiated when 10% KOH mount was positive for fungal filaments. Else, the patients were started on combined topical ciprofloxacin (0.3%) and fortified cefazolin (5%). RESULTS: 41/103 (39.8%) smears were positive for fungus and 62 (60.2%) were negative. 89 out of 103 patients (86.40%) healed with scarring at an average of 2.95±1.58 weeks. Healing was noted in 39/41 (95.12%) of patients at an average of 3.06±1.19 weeks in patients with KOH smear positive keratitis. 80.64% (50/62) healed with scarring at an average period of 2.86±1.86 weeks in KOH mount negative keratitis. CONCLUSIONS: Initial smear examination of KOH mount by an ophthalmologist helped in diagnosis of infectious keratitis caused by fungi and its management and 95.12% of KOH positive patients healed with scarring. Reading of KOH mount by an ophthalmologist helped in initiation of specific therapy with improved clinical outcome.
[Mh] Termos MeSH primário: Antifúngicos/uso terapêutico
Córnea/microbiologia
Infecção Hospitalar/microbiologia
Infecções Oculares Fúngicas/microbiologia
Fungos/isolamento & purificação
Ceratite/microbiologia
Técnicas Microbiológicas
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Infecção Hospitalar/diagnóstico
Infecção Hospitalar/tratamento farmacológico
Gerenciamento Clínico
Infecções Oculares Fúngicas/diagnóstico
Infecções Oculares Fúngicas/tratamento farmacológico
Feminino
Seres Humanos
Ceratite/diagnóstico
Ceratite/tratamento farmacológico
Masculino
Meia-Idade
Gravidez
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1136/bjophthalmol-2017-310241



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