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[PMID]:28461086
[Au] Autor:Arando A; Gonzalez A; Delgado JV; Arrebola FA; Perez-Marín CC
[Ad] Endereço:Department of Genetics, Faculty of Veterinary Medicine, University of Cordoba, Cordoba 14014, Spain.
[Ti] Título:Storage temperature and sucrose concentrations affect ram sperm quality after vitrification.
[So] Source:Anim Reprod Sci;181:175-185, 2017 Jun.
[Is] ISSN:1873-2232
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to analyse the characteristics of ram spermatozoa subjected to varying concentrations of sucrose, and the influence of storage temperature (22°C or 5°C) prior to vitrification. Ejaculated semen was diluted in TCFEY (tris-citric acid-fructose 20% egg yolk), and two aliquots were prepared at a final concentration of 100×10 spz/ml, one maintained at room temperature (22°C) and the other at 5°C. In the first experiment, the toxicity of sucrose diluents on the sperm was analysed; sperm samples at different temperatures were diluted (1:2) in TCF-BSA 2% (control) or in the same extender supplemented with various sucrose concentrations (0.4M, 0.6M and 0.8M). The effects of vitrification were studied in the second experiment, where sperm samples were mixed with different concentrations of cryoprotectants (sucrose) and vitrified by being plunged directly into liquid nitrogen. In both experiments, the sperm quality was assessed by measuring motility, morphology, membrane functionality (HOST), viability, acrosome integrity and DNA fragmentation. The toxicity test revealed significant differences (p≤0.05) when different sucrose concentrations were used; lower total and progressive motility, normal morphology and membrane functionality were noted when sucrose concentration was higher, compared to the control treatment. Samples maintained at room temperature showed significantly (p≤0.05) higher viability than samples stored at 5°C. In contrast, although the quality of vitrified sperm was drastically decreased in comparison with fresh sperm, sucrose was associated with greater total motility, viability and membrane functionality. This improvement was closely linked to the temperature at which the sperm had been previously maintained, showing higher values when sperm was stored at 5°C. The main conclusions to be drawn from the study are therefore that sucrose shows promising potential as a cryoprotectant, and storing samples at 5°C is linked to improved sperm quality following vitrification.
[Mh] Termos MeSH primário: Análise do Sêmen/veterinária
Preservação do Sêmen/veterinária
Ovinos/fisiologia
Sacarose/farmacologia
[Mh] Termos MeSH secundário: Animais
Criopreservação
Crioprotetores/farmacologia
Fragmentação do DNA/efeitos dos fármacos
Masculino
Sêmen/efeitos dos fármacos
Contagem de Espermatozoides
Motilidade Espermática/efeitos dos fármacos
Temperatura Ambiente
Vitrificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cryoprotective Agents); 57-50-1 (Sucrose)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:29339528
[Au] Autor:Engels M; Gehrmann K; Falhammar H; Webb EA; Nordenström A; Sweep FC; Span PN; van Herwaarden AE; Rohayem J; Richter-Unruh A; Bouvattier C; Köhler B; Kortmann BB; Arlt W; Roeleveld N; Reisch N; Stikkelbroeck NMML; Claahsen-van der Grinten HL; dsd-LIFE group
[Ad] Endereço:Department of PediatricsAmalia Children's Hospital, Radboud University Medical Center, Nijmegen, the Netherlands.
[Ti] Título:Gonadal function in adult male patients with congenital adrenal hyperplasia.
[So] Source:Eur J Endocrinol;178(3):285-294, 2018 Mar.
[Is] ISSN:1479-683X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Current knowledge on gonadal function in congenital adrenal hyperplasia (CAH) is mostly limited to single-center/country studies enrolling small patient numbers. Overall data indicate that gonadal function can be compromised in men with CAH. OBJECTIVE: To determine gonadal function in men with CAH within the European 'dsd-LIFE' cohort. DESIGN: Cross-sectional clinical outcome study, including retrospective data from medical records. METHODS: Fourteen academic hospitals included 121 men with CAH aged 16-68 years. Main outcome measures were serum hormone concentrations, semen parameters and imaging data of the testes. RESULTS: At the time of assessment, 14/69 patients had a serum testosterone concentration below the reference range; 7 of those were hypogonadotropic, 6 normogonadotropic and 1 hypergonadotropic. In contrast, among the patients with normal serum testosterone (55/69), 4 were hypogonadotropic, 44 normogonadotropic and 7 hypergonadotropic. The association of decreased testosterone with reduced gonadotropin concentrations (odds ratio (OR) = 12.8 (2.9-57.3)) was weaker than the association between serum androstenedione/testosterone ratio ≥1 and reduced gonadotropin concentrations (OR = 39.3 (2.1-732.4)). Evaluation of sperm quality revealed decreased sperm concentrations (15/39), motility (13/37) and abnormal morphology (4/28). Testicular adrenal rest tumor (TART)s were present in 39/80 patients, with a higher prevalence in patients with the most severe genotype (14/18) and in patients with increased current 17-hydroxyprogesterone 20/35) or androstenedione (12/18) serum concentrations. Forty-three children were fathered by 26/113 patients. CONCLUSIONS: Men with CAH have a high risk of developing hypothalamic-pituitary-gonadal disturbances and spermatogenic abnormalities. Regular assessment of endocrine gonadal function and imaging for TART development are recommended, in addition to measures for fertility protection.
[Mh] Termos MeSH primário: Hiperplasia Suprarrenal Congênita/sangue
Androstenodiona/sangue
Gonadotropinas/sangue
Hipogonadismo/sangue
Testosterona/sangue
[Mh] Termos MeSH secundário: Adolescente
Hiperplasia Suprarrenal Congênita/complicações
Hiperplasia Suprarrenal Congênita/epidemiologia
Tumor de Resto Suprarrenal/sangue
Tumor de Resto Suprarrenal/epidemiologia
Adulto
Idoso
Estudos Transversais
Europa (Continente)/epidemiologia
Seres Humanos
Hidroxiprogesteronas/sangue
Hipogonadismo/complicações
Masculino
Meia-Idade
Razão de Chances
Oligospermia/complicações
Prevalência
Análise do Sêmen
Contagem de Espermatozoides
Motilidade Espermática
Neoplasias Testiculares/sangue
Neoplasias Testiculares/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gonadotropins); 0 (Hydroxyprogesterones); 3XMK78S47O (Testosterone); 409J2J96VR (Androstenedione)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.1530/EJE-17-0862


  3 / 2812 MEDLINE  
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[PMID]:29369214
[Au] Autor:Lee HW; Kil KJ; Lee Y; Lee MS
[Ad] Endereço:KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon.
[Ti] Título:Ginseng for improving semen quality parameters: A protocol of systematic review.
[So] Source:Medicine (Baltimore);97(4):e9732, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The aim of this systematic review is to determine whether ginseng is effective in improving sperm quality. METHODS AND ANALYSIS: Twelve databases will be searched from their inception to the present date: PubMed, EMBASE, AMED, the Cochrane Library, 5 Korean medical databases (KoreaMed, DBpia, OASIS, the Research Information Service System [RISS], and the Korean Studies Information Service System [KISS]), and 3 Chinese medical databases (China National Knowledge Infrastructure [CNKI], the Wanfang Database, and the Chinese Scientific Journals Database [VIP]). We will include all prospective clinical trials including randomized controlled trials (RCTs), controlled trials, and uncontrolled observational studies. We will exclude case study and case series, and retrospective studies in which healthy men or men with subfertility are treated with any type of ginseng. We will exclude studies comparing the 2 different forms of ginseng. The selection of the studies, data abstraction, and validations will be performed independently by 2 researchers. The risk of bias of the RCTs will be evaluated using the Cochrane's risk of bias assessment tool. ETHICS AND DISSEMINATION: The findings will be disseminated to appropriate audiences via peer-reviewed publications and conference presentations. Our review will provide readers the opportunity to access studies originally published in East Asian languages that they would otherwise be unable to read. TRIAL REGISTRATION NUMBER: PROSPERO 2017 CRD42017078797.
[Mh] Termos MeSH primário: Panax
Análise do Sêmen
Sêmen/efeitos dos fármacos
[Mh] Termos MeSH secundário: Protocolos Clínicos
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009732


  4 / 2812 MEDLINE  
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[PMID]:29369195
[Au] Autor:Kim KI; Jo J
[Ad] Endereço:Department of Clinical Korean Medicine, College of Korean Medicine, Kyung Hee University.
[Ti] Título:The effectiveness of Korean medicine treatment in male patients with infertility: a study protocol for a prospective observational pilot study.
[So] Source:Medicine (Baltimore);97(4):e9696, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Male factor subfertility has increasingly been considered the cause of infertility in couples. Many men with male infertility have sperm problems such as oligozoospermia, asthenozoospermia, or teratozoospermia. Because abnormal semen parameters are idiopathic to some extent, no standard therapy has been established to date. Herbal medicine has been reported to have beneficial properties in the treatment of subfertility, especially in improving semen quality both in vivo and in human studies. Therefore, we intend to investigate the effectiveness and safety of treatment using Korean medicine (KM) for infertile male patients with poor semen quality.This will be a single-center, prospective, case-only observational pilot study. About 20 male patients with infertility who visit Conmaul Hospital of Korean Medicine will be recruited. We will follow the standard treatment protocol, which has shown good results in the treatment of male infertility. The protocol is composed mainly of a 10-week herbal decoction treatment; acupuncture and/or pharmacopuncture are added when needed. Semen samples, quality of life, and the scrotal temperatures of infertile men will be observed before and after the 10-week treatment with KM.The study has received ethical approval from the Public Institutional Review Board (approval number: P01-201708-21-008). The findings will be disseminated to appropriate audiences via peer-reviewed publication and conference presentations. TRIAL REGISTRATION: Korean Clinical Trial Registry (CRIS), Republic of Korea: KCT0002611.
[Mh] Termos MeSH primário: Terapia por Acupuntura/métodos
Infertilidade Masculina/terapia
Medicina Tradicional Coreana/métodos
Fitoterapia/métodos
[Mh] Termos MeSH secundário: Adulto
Protocolos Clínicos
Terapia Combinada
Seres Humanos
Infertilidade Masculina/etiologia
Masculino
Projetos Piloto
Estudos Prospectivos
República da Coreia
Sêmen/efeitos dos fármacos
Análise do Sêmen
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009696


  5 / 2812 MEDLINE  
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[PMID]:28747152
[Au] Autor:Skowronek MF; Velazquez T; Mut P; Figueiro G; Sans M; Bertoni B; Sapiro R
[Ad] Endereço:Departamento de Histología y Embriología, Facultad de Medicina UDELAR, Montevideo, Uruguay.
[Ti] Título:Associations between male infertility and ancestry in South Americans: a case control study.
[So] Source:BMC Med Genet;18(1):78, 2017 07 26.
[Is] ISSN:1471-2350
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Infertility affects 15% of human couples, with men being responsible in approximately 50% of cases. Moreover, the aetiology of male factor infertility is poorly understood. The majority of male factor infertility remains idiopathic and potentially genetic in origin. The association of the Y chromosome and mitochondrial haplogroups with male infertility has been previously reported. This association differs between studied populations and their geographical distributions. These effects have been only rarely analysed in mixed populations, such as South Americans. METHODS: In this study, we analysed the contributions of the Y chromosome and mitochondrial haplogroups to male infertility in a mixed population. A case control study was conducted. Regular PCR and high-resolutionmelting- real-time PCR were performed to type haplogroups from fertile and infertile men. The sperm parameters from infertile men were compared in each haplogroup by logistic regression analysis and ANOVA. RESULTS: The genotyping confirmed the known admixture characteristic of the Uruguayan population. The European paternal contribution was higher than the maternal contribution in both fertile and infertile men. Neither maternal nor paternal ancestry presented differences between the cases and controls. Men belonging to the Y chromosome haplogroup F(xK) more frequently presented with an abnormal sperm morphology than men from other haplogroups. The sperm parameters were not associated with the mitochondrial haplogroups. CONCLUSIONS: The data presented in this study showed an association between male infertility and ancestry in the Uruguayan population. Specifically, abnormal sperm morphology was associated with the Y chromosome haplogroup F(xK). Since the Y chromosome lacks recombination, these data suggest that some genes that determine sperm morphology might be inherited in blocks with the region that determines specific haplogroups. However, the possible association between the Y chromosome haplogroup F(xK) and sperm morphology requires further confirmatory testing. Data linking infertility with ancestry are needed to establish the possible causes of infertility and define male populations susceptible to infertility. Whether the admixed characteristics of the Uruguayan population exert any pressure on male fertility potential must be further investigated.
[Mh] Termos MeSH primário: Cromossomos Humanos Y
Grupos de Populações Continentais
Infertilidade Masculina/etnologia
Infertilidade Masculina/genética
[Mh] Termos MeSH secundário: Estudos de Casos e Controles
Cromossomos Humanos Y/genética
Grupos de Populações Continentais/genética
Grupos de Populações Continentais/estatística & dados numéricos
Fertilidade/genética
Genes Mitocondriais
Haplótipos
Seres Humanos
Masculino
Filogenia
Análise do Sêmen
América do Sul/epidemiologia
Uruguai/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1186/s12881-017-0438-z


  6 / 2812 MEDLINE  
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[PMID]:29016685
[Au] Autor:Dardmeh F; Alipour H; Gazerani P; van der Horst G; Brandsborg E; Nielsen HI
[Ad] Endereço:Biomedicine Group, Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark.
[Ti] Título:Lactobacillus rhamnosus PB01 (DSM 14870) supplementation affects markers of sperm kinematic parameters in a diet-induced obesity mice model.
[So] Source:PLoS One;12(10):e0185964, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Probiotics have been proposed as alternatives to pharmacological products in several medical conditions including the modulation of obesity, which is frequently associated with poor semen quality. However, effects of probiotics on male fertility have been less investigated. This study assessed the effect of Lactobacillus rhamnosus PB01 (DSM-14870) on sperm kinematic parameters in Normal-weight (NW) and diet-induced obese (DIO) models. NW and DIO C57BL/6NTac mice were divided into two subgroups with or without a single daily dose (1x109CFU) of L. rhamnosus for four weeks. Sperm motility and kinematics together with blood lipid profiles and reproductive hormone levels were assessed using the sperm class analyzer system. Probiotic supplementation increased serum testosterone, LH and FSH levels in both NW and DIO groups resulting in significantly (P<0.05) higher velocity (VSL, VCL and VAP) and percentages of progressively motile sperm and significantly lower percentages of immotile sperm. Other kinematic parameters (Lin, STR, ALH and BCF) were also increased in both probiotic supplemented DIO and NW groups at the 10% level of significance. Probiotic supplemented DIO mice demonstrated significantly higher percentages of progressively motile sperm versus DIO controls. This study demonstrated the potential of L. rhamnosus PB01 as a regulatory agent with positive effects on weight loss and reproductive-hormones, significantly improving sperm motility and kinematic parameters in male DIO models.
[Mh] Termos MeSH primário: Fertilidade/fisiologia
Lactobacillus rhamnosus/fisiologia
Obesidade/fisiopatologia
Probióticos/administração & dosagem
Motilidade Espermática/fisiologia
[Mh] Termos MeSH secundário: Animais
Biomarcadores/sangue
Dieta Hiperlipídica/efeitos adversos
Hormônio Foliculoestimulante/sangue
Hormônio Luteinizante/sangue
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Obesidade/sangue
Obesidade/etiologia
Obesidade/patologia
Análise do Sêmen/estatística & dados numéricos
Contagem de Espermatozoides
Espermatozoides/citologia
Espermatozoides/fisiologia
Testosterona/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 3XMK78S47O (Testosterone); 9002-67-9 (Luteinizing Hormone); 9002-68-0 (Follicle Stimulating Hormone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171011
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185964


  7 / 2812 MEDLINE  
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[PMID]:28952695
[Au] Autor:Osadchuk LV; Popova AV; Erkovich AA; Voroshilova NA; Osadchuk AV
[Ad] Endereço:Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the RAS.
[Ti] Título:[Effects of smoking and alcohol consumptionon reproductive and metabolic indicators in young men in western siberia].
[So] Source:Urologiia;(4):62-67, 2017 Sep.
[Is] ISSN:1728-2985
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:INTRODUCTION: Smoking and alcohol consumption remain widespread throughout the world, including Russia. Recently, due to the increase in male infertility and subfertility, special attention has been paid to the effects of smoking and alcohol on the reproductive health of young men. The aim of this study was to assess the effects of smoking and moderate alcohol consumption on spermatogenesis, reproductive hormone levels and metabolic status in young men living in Western Siberia (Novosibirsk). MATERIALS AND METHODS: One hundred thirty-three volunteers (mean age 21.1+/-0.3 years) were tested for the sperm concentration, the proportion of mobile and morphologically normal spermatozoa in the ejaculate, blood serum levels of follicle-stimulating and luteinizing hormones, prolactin, testosterone, estradiol, inhibin B, triglycerides, total cholesterol, high and low density lipoprotein cholesterol, glucose and uric acid. RESULTS: and conclusions The studied lifestyle factors were found to have no effects on spermatogenesis. Smoking more than 10 cigarettes per day and a moderate frequency of alcohol consumption (up to 1 time per week) was associated with higher blood serum testosterone levels and engaging in more frequent sexual contacts compared to non-smoking and non-drinking men. Drinking alcohol more than once a week and smoking more than 8 cigarettes per day was associated, along with the increase in testosterone levels and the frequency of sexual contacts, with lower levels of follicle-stimulating hormone and higher serum triglyceride levels. Thus, in young men, frequent drinking and smoking can alter the hormonal and metabolic balance, which, as the duration of the exposure and the strength of the factors increase, will increase the risk of reproductive disorders.
[Mh] Termos MeSH primário: Consumo de Bebidas Alcoólicas/efeitos adversos
Reprodução
Fumar/efeitos adversos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Consumo de Bebidas Alcoólicas/sangue
Glicemia/análise
Colesterol/sangue
Estradiol/sangue
Hormônio Foliculoestimulante/sangue
Seres Humanos
Inibinas/sangue
Hormônio Luteinizante/sangue
Masculino
Prolactina/sangue
Análise do Sêmen
Sibéria
Fumar/sangue
Espermatogênese
Testosterona/sangue
Triglicerídeos/sangue
Ácido Úrico/sangue
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Triglycerides); 0 (inhibin B); 268B43MJ25 (Uric Acid); 3XMK78S47O (Testosterone); 4TI98Z838E (Estradiol); 57285-09-3 (Inhibins); 9002-62-4 (Prolactin); 9002-67-9 (Luteinizing Hormone); 9002-68-0 (Follicle Stimulating Hormone); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE


  8 / 2812 MEDLINE  
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[PMID]:28923283
[Au] Autor:Jansen CHJR; Elisen MGLM; Leenstra CW; Kaaijk EM; van Stralen KJ; Verhoeve HR
[Ad] Endereço:Department of Obstetrics and Gynaecology, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands. Electronic address: chjr.jansen@gmail.com.
[Ti] Título:Longer time interval between semen processing and intrauterine insemination does not affect pregnancy outcome.
[So] Source:Fertil Steril;108(5):764-769, 2017 Nov.
[Is] ISSN:1556-5653
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To study whether the pregnancy outcome of intrauterine insemination (IUI) is affected by a longer time interval between semen processing and insemination. DESIGN: Retrospective cohort. SETTING: Teaching hospital. PATIENT(S): Couples with subfertility and an indication for IUI over a 10-year period. INTERVENTION (S): Insemination performed the day after but within 24 hours of semen collection and processing (delayed insemination) compared with insemination performed immediately after sperm collection and processing (immediate insemination). MAIN OUTCOME MEASURE(S): Ongoing pregnancy rate, defined as a pregnancy confirmed by ultrasound at 10 to 12 weeks of gestation. RESULT(S): In total, 1,136 cycles were analyzed. In 77 of 547 couples (14%) an ongoing pregnancy occurred after delayed insemination, and in 77 of 589 couples (13%) an ongoing pregnancy occurred after immediate insemination. Both groups had similar baseline characteristics. After adjustment for confounders, there was no difference in the ongoing pregnancy rate between delayed as compared with immediate insemination (odds ratio 0.89; 95% confidence interval, 0.63-1.25). CONCLUSION(S): There is no negative effect on pregnancy rate when IUI of processed sperm is delayed until the next day. This approach allows additional flexibility for couples when the male partner is not available on the day of ovulation, and it allows for a spread of workload in the laboratory.
[Mh] Termos MeSH primário: Infertilidade/terapia
Inseminação Artificial/métodos
Manejo de Espécimes/métodos
Tempo para o Tratamento
Doadores de Tecidos
[Mh] Termos MeSH secundário: Adulto
Feminino
Fertilidade
Seres Humanos
Infertilidade/diagnóstico
Infertilidade/fisiopatologia
Inseminação Artificial/efeitos adversos
Modelos Logísticos
Masculino
Análise Multivariada
Razão de Chances
Gravidez
Resultado da Gravidez
Taxa de Gravidez
Estudos Retrospectivos
Fatores de Risco
Análise do Sêmen
Manejo de Espécimes/efeitos adversos
Fatores de Tempo
Resultado do Tratamento
Ultrassonografia Pré-Natal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170920
[St] Status:MEDLINE


  9 / 2812 MEDLINE  
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[PMID]:28915245
[Au] Autor:Lueders I; Young D; Maree L; van der Horst G; Luther I; Botha S; Tindall B; Fosgate G; Ganswindt A; Bertschinger HJ
[Ad] Endereço:GEOlifes-Animal Fertility and Reproductive Research, Frohmestr. 7, Hamburg, Germany.
[Ti] Título:Effects of GnRH vaccination in wild and captive African Elephant bulls (Loxodonta africana) on reproductive organs and semen quality.
[So] Source:PLoS One;12(9):e0178270, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Although the African elephant (Loxodonta africana) is classified as endangered by the International Union for Conservation of Nature (IUCN), in some isolated habitats in southern Africa, contraception is of major interest due to local overpopulation. GnRH vaccination has been promoted as a non-invasive contraceptive measure for population management of overabundant wildlife. We tested the efficacy of this treatment for fertility control in elephant bulls. METHODS: In total, 17 male African elephants that were treated with a GnRH vaccine were examined in two groups. In the prospective study group 1 (n = 11 bulls, ages: 8-36 years), semen quality, the testes, seminal vesicles, ampullae and prostate, which were all measured by means of transrectal ultrasound, and faecal androgen metabolite concentrations were monitored over a three-year period. Each bull in the prospective study received 5 ml of Improvac® (1000 µg GnRH conjugate) intramuscularly after the first examination, followed by a booster six weeks later and thereafter every 5-7 months. In a retrospective study group (group 2, n = 6, ages: 19-33 years), one examination was performed on bulls which had been treated with GnRH vaccine for 5-11 years. RESULTS: In all bulls of group 1, testicular and accessory sex gland sizes decreased significantly after the third vaccination. In six males examined prior to vaccination and again after more than five vaccinations, the testis size was reduced by 57.5%. Mean testicular height and length decreased from 13.3 ± 2.6 cm x 15.2 ± 2.8 cm at the beginning to 7.6 ± 2.1 cm x 10.2 ± 1.8 cm at the end of the study. Post pubertal bulls (>9 years, n = 6) examined prior to vaccination produced ejaculates with viable spermatozoa (volume: 8-175 ml, sperm concentration: 410-4000x106/ml, total motility: 0-90%), while after 5-8 injections, only 50% of these bulls produced ejaculates with a small number of immotile spermatozoa. The ejaculates of group 2 bulls (vaccinated >8 times) were devoid of spermatozoa. Faecal androgen metabolite concentrations measured in captive males decreased significantly after the fourth vaccination. None of the males entered musth during the treatment period. CONCLUSIONS: Our results showed a marked decrease in semen quality, testicle and secondary sex gland sizes following repeated GnRH vaccinations. After 2-4 years of continuous treatment every 5-7 months, the effects were similar to surgical castration.
[Mh] Termos MeSH primário: Anticoncepção Imunológica
Elefantes
Hormônio Liberador de Gonadotropina
Reprodução
Análise do Sêmen
Testículo
Vacinação
[Mh] Termos MeSH secundário: Animais
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
33515-09-2 (Gonadotropin-Releasing Hormone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170916
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178270


  10 / 2812 MEDLINE  
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[PMID]:28911932
[Au] Autor:Samplaski MK; Lo KC; Grober ED; Zini A; Jarvi KA
[Ad] Endereço:Institute of Urology, University of Southern California, Los Angeles, California. Electronic address: mary.samplaski@med.usc.edu.
[Ti] Título:Varicocelectomy to "upgrade" semen quality to allow couples to use less invasive forms of assisted reproductive technology.
[So] Source:Fertil Steril;108(4):609-612, 2017 Oct.
[Is] ISSN:1556-5653
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To determine the magnitude of improvement in semen parameters after a varicocelectomy and the fraction that have improvements such that couples needing IVF or IUI are "upgraded" to needing less invasive assisted reproductive technology (ART). DESIGN: Retrospective review of prospectively collected data. SETTING: Academic medical centers. PATIENT(S): Men presenting for a fertility evaluation with a clinical varicocele. INTERVENTION(S): Varicocele repair (surgical or embolization). MAIN OUTCOME MEASURE(S): Total motile sperm count (TMSC) before and after repair, and the proportion of men considered candidates for: natural pregnancy (NP) >9 million, IUI 5-9 million, or IVF < 5 million. RESULT(S): A total of 373 men underwent varicocele repair. The TMSC increased from 18.22 ± 38.32 to 46.72 ± 210.92 (P=.007). The most pronounced increase was with baseline TMSC <5 million, from 2.32 ± 1.50 to 15.97 ± 32.92 (P=.0000002); 58.8% of men were upgraded from IVF candidacy to IUI or NP. For baseline TMSC 5-9 million, the mean TMSC increased from 6.96 ± 1.16 to 24.29 ± 37.17 (P=.0004), allowing 64.9% of men to become candidates for NP. For baseline TMSC of >9 million, TMSC increased from 36.26 ± 52.08 to 81.80 ± 310.83 (P=.05). CONCLUSION(S): Varicocele repair has an important role in the treatment of infertility. Even for low TMSCs, a varicocelectomy may reduce the need for IVF. Varicocele repair (by embolization or microsurgery) potentially reduces the need for IVF and IUI.
[Mh] Termos MeSH primário: Infertilidade Masculina/cirurgia
Técnicas de Reprodução Assistida
Análise do Sêmen
Procedimentos Cirúrgicos Urogenitais/métodos
Varicocele/cirurgia
[Mh] Termos MeSH secundário: Adulto
Características da Família
Feminino
Seres Humanos
Infertilidade Masculina/epidemiologia
Infertilidade Masculina/etiologia
Masculino
Microcirurgia/métodos
Meia-Idade
Gravidez
Taxa de Gravidez
Estudos Retrospectivos
Contagem de Espermatozoides
Varicocele/complicações
Varicocele/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170916
[St] Status:MEDLINE



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