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[PMID]:28254223
[Au] Autor:Chao AS; Chang YL; Chao A; Wu TS; Yang LY; Lian R; Huang YC
[Ad] Endereço:Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan. Electronic address: aschao1295@cgmh.org.tw.
[Ti] Título:Seropositivity of influenza A H1NI in mothers and infants following maternal vaccination with trivalent seasonal influenza vaccine after the 2009 pandemic.
[So] Source:Taiwan J Obstet Gynecol;56(1):37-40, 2017 Feb.
[Is] ISSN:1875-6263
[Cp] País de publicação:China (Republic : 1949- )
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To assess H1N1 antibody titers between vaccinated and nonvaccinated maternal and cord blood sera after the 2009 pandemic. MATERIALS AND METHODS: Antibody titers were measured in maternal blood and cord sera from three groups of pregnant women in this prospective study. Group 1 comprised women who received a trivalent seasonal influenza vaccine before conception, Group 2 comprised women who received a single injection of monovalent H1N1 vaccine during pregnancy, and Group 3 comprised women who were nonvaccinated. A seropositive or seroprotective hemagglutination inhibition (HAI) assay was defined as titer ≥ 1:40. RESULTS: In this study, 500 healthy women were enrolled, of which 44 women were in the trivalent seasonal influenza vaccine group, 41 women were in the monovalent vaccine group, and 415 women were in the nonvaccinated group. The seropositive HAI titers in the three groups of mothers were 48%, 78%, and 12%, respectively. The HAI titers in the vaccinated groups were significantly higher than those in the nonvaccinated group. The HAI titers of the cord blood samples of the three groups were comparable to their respective maternal samples. CONCLUSION: Seroprotection after the 2009 HIN1 pandemic was generally low in pregnant women. Vaccination during pregnancy yielded best seropositivity, whereas receiving a trivalent seasonal influenza vaccine before conception can offer better seroprotection to mothers and newborns than no vaccination.
[Mh] Termos MeSH primário: Anticorpos Antivirais/sangue
Sangue Fetal/imunologia
Vírus da Influenza A Subtipo H1N1/imunologia
Vacinas contra Influenza/imunologia
Influenza Humana/imunologia
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Cordocentese
Feminino
Seres Humanos
Lactente
Recém-Nascido
Vacinas contra Influenza/administração & dosagem
Influenza Humana/epidemiologia
Influenza Humana/prevenção & controle
Masculino
Pandemias/estatística & dados numéricos
Vigilância da População
Gravidez
Estudos Prospectivos
Taiwan/epidemiologia
Vacinação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (Influenza Vaccines)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE


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[PMID]:27519283
[Au] Autor:Zhang X; Li C; Mao J; Wang W; Xie X; Peng S; Wang Z; Han C; Zhang X; Wang D; Fan C; Shan Z; Teng W
[Ad] Endereço:The Endocrine Institute and the Liaoning Provincial Key Laboratory of Endocrine Diseases, Department of Endocrinology and Metabolism, the First Hospital of China Medical University, Heping District, Shenyang, China.
[Ti] Título:Gestation-specific changes in maternal thyroglobulin during pregnancy and lactation in an iodine-sufficient region in China: a longitudinal study.
[So] Source:Clin Endocrinol (Oxf);86(2):229-235, 2017 Feb.
[Is] ISSN:1365-2265
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To describe the changes in thyroglobulin (Tg) based upon gestational and postpartum concentrations in healthy pregnant women from an iodine-sufficient region in China, and to evaluate the use of Tg as a biomarker for iodine-sufficient pregnant women. DESIGN: A longitudinal study of Tg change in normal pregnant women from an iodine-sufficient region. PATIENTS AND MEASUREMENTS: Blood and urine samples were obtained from 133 pregnant women. Urinary iodine concentration (UIC) was measured using an ammonium persulfate method. Serum iodine concentration was required by inductively coupled plasma mass spectrometry (ICP-MS). Serum thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), total thyroxine (TT4), total triiodothyronine (TT3), antithyroid peroxidase antibody (TPOAb), antithyroglobulin antibody (TgAb) and Tg were measured using an electrochemiluminescence immunoassay. RESULTS: Thyroglobulin concentrations were higher in early pregnancy (pregnancy at 8 weeks vs nonpregnancy: 11·42 ng/ml vs 8·8 ng/ml, P < 0·01) and maintained a stable level, and then increased greatly at the 36th week. After delivery, Tg decreased to nonpregnant levels. During pregnancy, maternal Tg was not correlated with thyroid function, UIC or urine iodine-creatinine ratio (UI/Cr). Cord blood Tg was much higher compared to maternal Tg levels at the 36w (57·34 vs 14·86 ng/ml, P < 0·001) and correlated positively with cord FT4 (r = 0·256, P < 0·05), cord TT4 (r = 0·263, P < 0·05) and maternal UI/Cr at 36w (r = -0·214, P < 0·05). CONCLUSIONS: Our work demonstrates that Tg is elevated during pregnancy, and the effect of pregnancy should be taken into consideration when Tg is used as a biomarker for the iodine status. Cord blood Tg is much higher than maternal Tg levels at the 36w and is correlated with maternal iodine status.
[Mh] Termos MeSH primário: Iodo/análise
Gravidez
Tireoglobulina/sangue
[Mh] Termos MeSH secundário: Adulto
Biomarcadores/sangue
Biomarcadores/urina
Estudos de Casos e Controles
China
Cordocentese
Feminino
Hormônios/sangue
Hormônios/urina
Seres Humanos
Iodo/sangue
Iodo/urina
Lactação
Estudos Longitudinais
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Hormones); 9010-34-8 (Thyroglobulin); 9679TC07X4 (Iodine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160814
[St] Status:MEDLINE
[do] DOI:10.1111/cen.13175


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[PMID]:28361594
[Au] Autor:Lee HH; Mak AS; Kou KO; Poon CF; Wong WS; Chiu KH; Au PK; Chan KY; Kan AS; Tang MH; Leung KY
[Ad] Endereço:a Department of Obstetrics and Gynaecology , Queen Elizabeth Hospital , Hong Kong SAR , People's Republic of China.
[Ti] Título:An Unusual Hydrops Fetalis Associated with Compound Heterozygosity for Krüppel-like Factor 1 mutations.
[So] Source:Hemoglobin;40(6):431-434, 2016 Nov.
[Is] ISSN:1532-432X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Hydrops fetalis is commonly due to Hb Bart's (γ4) disease in South East Asia. Here, we report an unusual case of hydrops fetalis due to congenital dyserythropoietic anemia (CDA) associated with compound heterozygosity for Krüppel-like factor 1 (KLF1) gene mutations. Fetal cardiomegaly was first detected on routine mid-trimester scan in a pregnant woman with normal mean corpuscular volume (MCV) and Rhesus positive status. The fetus subsequently developed hydrops fetalis, and cordocentesis showed severe fetal anemia with a hemoglobin (Hb) level of 3.4 g/dL. Common causes of fetal anemia including Hb Bart's disease, parvovirus infection, and red cell antibodies were excluded. In view of the marked increase in erythroblasts at various stages of erythropoiesis, the diagnosis of CDA was suspected. We screened the couple for previously reported KLF1 gene mutations, showing that the mother was heterozygous for the c.525_526insCGGCGCC, p.Gly176Argfs*179 mutation, and her husband heterozygous for c.1012C>A, p.Pro338Thr mutation. The fetus was a compound heterozygote for these two KLF1 mutations. After counseling, repeated intrauterine transfusions were given at 27, 29, and 34 weeks' gestation; the hydrops fetalis was resolved. The baby was delivered at 34 weeks' gestation and required monthly blood transfusions but was otherwise thriving. Bone marrow aspiration at 10 months of age showed the features of ineffective erythropoiesis, compatible with CDA. In conclusion, hydrops fetalis can rarely be due to CDA associated with a compound heterozygous mutation for KLF1 gene mutations, and be managed by repeated intrauterine transfusions. Our present report adds to the wide clinical spectrum of KLF1 mutations.
[Mh] Termos MeSH primário: Anemia Diseritropoética Congênita/diagnóstico
Anemia Diseritropoética Congênita/genética
Heterozigoto
Hidropisia Fetal/genética
Fatores de Transcrição Kruppel-Like/genética
Mutação
[Mh] Termos MeSH secundário: Adulto
Anemia Diseritropoética Congênita/etiologia
Anemia Diseritropoética Congênita/terapia
Transfusão de Sangue Intrauterina
Exame de Medula Óssea
Cordocentese
Feminino
Seres Humanos
Hidropisia Fetal/diagnóstico
Hidropisia Fetal/etiologia
Hidropisia Fetal/terapia
Lactente
Masculino
Gravidez
Diagnóstico Pré-Natal
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Kruppel-Like Transcription Factors); 0 (erythroid Kruppel-like factor)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE
[do] DOI:10.1080/03630269.2016.1267017


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[PMID]:28040135
[Au] Autor:Libotte F; Bizzoco D; Gabrielli I; Mesoraca A; Cignini P; Vitale SG; Marilli I; Gulino FA; Rapisarda AM; Giorlandino C
[Ad] Endereço:Department of Genetics, Altamedica Fetal Maternal Medical Centre, Rome, Italy.
[Ti] Título:Pallister-Killian syndrome: Cytogenetics and molecular investigations of mosaic tetrasomy 12p in prenatal chorionic villus and in amniocytes. Strategy of prenatal diagnosis.
[So] Source:Taiwan J Obstet Gynecol;55(6):863-866, 2016 Dec.
[Is] ISSN:1875-6263
[Cp] País de publicação:China (Republic : 1949- )
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Pallister-Killian syndrome (PKS) is a rare, sporadic genetic disorder caused by mosaic tetrasomy of the short arm of chromosome 12 (12p). Clinically, PKS is characterized by several systemic abnormalities, such as intellectual impairment, hearing loss, epilepsy, hypotonia, craniofacial dysmorphism, pigmentary skin anomalies, epilepsy, and a variety of congenital malformations. Prenatally, PKS can be suspected in the presence of ultrasound anomalies: diaphragmatic hernia, rhizomelic micromelia, hydrops fetalis, fetal overweight, ventriculomegaly in the central nervous system, congenital heart defects, or absent visualization of the stomach. In all these cases, a detailed genetic study is required. PKS is diagnosed by prenatal genetic analysis through chorionic villus sampling, genetic amniocentesis, and cordocentesis. CASE REPORT: We report two cases of PKS with prenatal diagnosis of isochromosome 12p made by cytogenetic studies. The first case is of a 36-year-old pregnant woman who underwent genetic chorionic villus sampling at 13 weeks of gestation after 1 trimester prenatal ultrasound revealed clinical features of PKS: flat nasal bridge and fetal hydrops. The second case is of a 32-year-old pregnant woman with genetic amniocentesis at 17 weeks of gestation that showed mos46,XX[21]/47,XX,+i(12p) associated to PKS. CONCLUSION: New molecular cytogenetic techniques array comparative genomic hybridization and fluorescence in-situ hybridization in association with conventional karyotype are pivotal innovative tools to search for chromosomic anomalies and for a complete prenatal diagnosis, especially in cases such as PKS where array comparative genomic hybridization analysis alone could not show mosaicism of i(12p).
[Mh] Termos MeSH primário: Amniocentese
Transtornos Cromossômicos/diagnóstico
Transtornos Cromossômicos/genética
Testes Genéticos/métodos
Mosaicismo
Tetrassomia
[Mh] Termos MeSH secundário: Amostra da Vilosidade Coriônica
Cromossomos Humanos Par 12/genética
Hibridização Genômica Comparativa
Cordocentese
Feminino
Idade Gestacional
Seres Humanos
Hibridização in Situ Fluorescente
Cariotipagem
Gravidez
Ultrassonografia Pré-Natal
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170102
[St] Status:MEDLINE


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[PMID]:27442223
[Au] Autor:Srisupundit K; Tongprasert F; Luewan S; Traisrisilp K; Jatavan P; Tongsong T
[Ad] Endereço:Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Thailand. ksrisupundit@yahoo.com.
[Ti] Título:Effect of cordocentesis on fetal myocardial performance.
[So] Source:Prenat Diagn;36(9):871-4, 2016 Sep.
[Is] ISSN:1097-0223
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To compare fetal Tei index before, immediately after and 30 min after cordocentesis for prenatal diagnosis. PATIENTS AND METHODS: Pregnant women undergoing prenatal diagnostic cordocentesis in the early mid-trimester underwent measurement of the fetal Tei index of both right and left ventricles just before cordocentesis, immediately after and at 30 min after the procedure. RESULTS: A total of 143 singleton women underwent cordocentesis at a median gestational age of 19 weeks (range 16-23). The most common indication was fetal risk of beta-thalassemia/hemoglobin E disease (42%, 60 cases). Immediately after cordocentesis, fetal Tei index and all its components at both ventricles were significantly altered when compared with the baseline values (p < 0.001). At 30 min after cordocentesis, components of the Tei index had significantly improved but 5/6 had not completely recovered. No serious procedure-related short-term complications were observed in the study. CONCLUSION: Cordocentesis has a negative impact on fetal hemodynamics as indicated by worsening of the Tei index. Although the adverse effect seems to be temporary, the recovery time may be longer than 30 min. © 2016 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Cordocentese/efeitos adversos
Coração Fetal/fisiologia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Gravidez
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160722
[St] Status:MEDLINE
[do] DOI:10.1002/pd.4876


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[PMID]:27131591
[Au] Autor:Lakkaraja M; Berkowitz RL; Vinograd CA; Manotas KC; Jin JC; Ferd P; Gabor J; Wissert M; McFarland JG; Bussel JB
[Ad] Endereço:Department of Pediatrics, Division of Hematology, Weill Cornell Medicine, New York, New York.
[Ti] Título:Omission of fetal sampling in treatment of subsequent pregnancies in fetal-neonatal alloimmune thrombocytopenia.
[So] Source:Am J Obstet Gynecol;215(4):471.e1-9, 2016 Oct.
[Is] ISSN:1097-6868
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Fetal-neonatal alloimmune thrombocytopenia affects approximately 1 of 1000 live births, most of which are not severely thrombocytopenic. Despite effective treatment with intravenous gammaglobulin and/or prednisone, antenatal management of a subsequent affected pregnancy is complicated by the risks associated with fetal blood sampling. Furthermore, there are no biomarker(s) of high risk other than the occurrence of intracranial hemorrhage in a previous sibling. Management of these high-risk pregnancies requires intensive treatment initiated at 12 weeks of gestation. OBJECTIVE: The objective of the study was to evaluate whether empiric escalation of therapy at 32 weeks allows the omission of fetal blood sampling in all fetal-neonatal alloimmune thrombocytopenia-affected patients. Specifically, we sought to determine whether intensive intravenous gammaglobulin-based regimens for the treatment of a subsequent fetal-neonatal alloimmune thrombocytopenia-affected pregnancy followed by empirically escalated intravenous gammaglobulin and prednisone treatment would increase the fetal platelet count and thus safely allow omission of fetal blood sampling in the antepartum management of these patients. STUDY DESIGN: In this prospective, multicenter, randomized controlled study, 99 women with fetal-neonatal alloimmune thrombocytopenia whose prior affected child did not have an intracranial hemorrhage were randomized to receive an intensive intravenous gammaglobulin-based regimen: 2 g/kg per week or intravenous gammaglobulin 1 g/kg per week plus prednisone 0.5 mg/kg per day, starting at 20-30 weeks of gestation. Escalated therapy (intravenous gammaglobulin 2 g/kg per week plus prednisone 0.5 mg/kg per day) was recommended and usually initiated at 32 weeks when fetal counts were <50,000/mL(3) or when fetal blood sampling was not performed. The preliminary report of this study from 2007 demonstrated the efficacy of both intravenous gammaglobulin-based regimens in most patients. Most patients who underwent fetal sampling had adequate fetal counts and therefore did not have their treatment escalated. This post hoc analysis describes the 29 fetuses who had their treatment escalated either because they had low counts at 32 weeks or when sampling was not performed. This study explored whether the empiric escalation of treatment at 32 weeks was sufficiently effective in increasing fetal platelet counts in these patients. RESULTS: Mean fetal and birth counts of fetuses randomized to each of the 2 initial treatment groups were all >100,000/mL(3). Three neonates had an intracranial hemorrhage; all 3 were grade 1 and all had birth platelet counts >130,000/mL(3). In a post hoc analysis, 19 fetuses undergoing fetal blood sampling at 32 weeks had fetal platelet counts <50,000/mL(3) despite their initial treatment. Of these 19, birth platelet counts were >50,000/mL(3) in 11 of 13 fetuses who received escalated treatment compared with only 1 of 6 of those who did not (P = .01); only 3 fetuses that received initial therapy followed by escalated treatment had birth platelet counts <50,000/mL(3) and none had an intracranial hemorrhage. The platelet counts of 14 of 15 fetuses that received empirically escalated treatment without sampling were >50,000/mL(3) at birth. In addition, none of these had an intracranial hemorrhage. CONCLUSION: The 2 recommended protocols of intensive initial treatment followed by empiric escalation of therapy at 32 weeks of gestation are reasonably safe, effective in increasing fetal platelet counts, and allow omission of fetal blood sampling by increasing the fetal platelet count in almost all cases.
[Mh] Termos MeSH primário: Imunoglobulinas Intravenosas/administração & dosagem
Fatores Imunológicos/administração & dosagem
Complicações na Gravidez/diagnóstico
Complicações na Gravidez/tratamento farmacológico
Trombocitopenia Neonatal Aloimune/diagnóstico
Trombocitopenia Neonatal Aloimune/tratamento farmacológico
[Mh] Termos MeSH secundário: Cordocentese/efeitos adversos
Feminino
Sangue Fetal
Idade Gestacional
Seres Humanos
Hemorragias Intracranianas/etiologia
Contagem de Plaquetas
Prednisona/administração & dosagem
Gravidez
Complicações na Gravidez/sangue
Diagnóstico Pré-Natal
Estudos Prospectivos
Trombocitopenia Neonatal Aloimune/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Immunoglobulins, Intravenous); 0 (Immunologic Factors); VB0R961HZT (Prednisone)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170526
[Lr] Data última revisão:
170526
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160502
[St] Status:MEDLINE


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Cereser, Keila Maria Mendes
[PMID]:27074340
[Au] Autor:Mardini V; Rohde LA; Ceresér KM; Gubert Cde M; da Silva EG; Xavier F; Parcianello R; Röhsig LM; Pechansky F; Pianca TG; Szobot CM
[Ad] Endereço:Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
[Ti] Título:IL-6 and IL-10 levels in the umbilical cord blood of newborns with a history of crack/cocaine exposure in utero: a comparative study.
[So] Source:Trends Psychiatry Psychother;38(1):40-9, 2016 Jan-Mar.
[Is] ISSN:2238-0019
[Cp] País de publicação:Portugal
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Prenatal cocaine exposure (PCE) is associated with neurobehavioral problems during childhood and adolescence. Early activation of the inflammatory response may contribute to such changes. Our aim was to compare inflammatory markers (IL-6 and IL-10) both in umbilical cord blood and in maternal peripheral blood at delivery between newborns with history of crack/cocaine exposure in utero and non-exposed newborns. METHODS: In this cross-sectional study, 57 newborns with a history of crack/cocaine exposure in utero (EN) and 99 non-exposed newborns (NEN) were compared for IL-6 and IL-10 levels. Sociodemographic and perinatal data, maternal psychopathology, consumption of nicotine and other substances were systematically collected in cases and controls. RESULTS: After adjusting for potential confounders, mean IL-6 was significantly higher in EN than in NEN (10,208.54, 95% confidence interval [95%CI] 1,328.54-19,088.55 vs. 2,323.03, 95%CI 1,484.64-3,161.21; p = 0.007; generalized linear model [GLM]). Mean IL-10 was also significantly higher in EN than in NEN (432.22, 95%CI 51.44-812.88 vs. 75.52, 95%CI 5.64-145.39, p = 0.014; GLM). Adjusted postpartum measures of IL-6 were significantly higher in mothers with a history of crack/cocaine use (25,160.05, 95%CI 10,958.15-39,361.99 vs. 8,902.14, 95%CI 5,774.97-12,029.32; p = 0.007; GLM), with no significant differences for IL-10. There was no correlation between maternal and neonatal cytokine levels (Spearman test, p ≥ 0.28 for all measures). CONCLUSIONS: IL-6 and IL-10 might be early biomarkers of PCE in newborns. These findings could help to elucidate neurobiological pathways underlying neurodevelopmental changes and broaden the range of possibilities for early intervention.
[Mh] Termos MeSH primário: Transtornos Relacionados ao Uso de Cocaína/complicações
Cocaína Crack
Sangue Fetal/metabolismo
Interleucina-10/sangue
Interleucina-6/sangue
Complicações na Gravidez/sangue
[Mh] Termos MeSH secundário: Adulto
Biomarcadores/sangue
Transtornos Relacionados ao Uso de Cocaína/sangue
Cordocentese
Estudos Transversais
Feminino
Seres Humanos
Recém-Nascido
Modelos Lineares
Masculino
Período Pós-Parto
Gravidez
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biomarkers); 0 (Crack Cocaine); 0 (IL10 protein, human); 0 (IL6 protein, human); 0 (Interleukin-6); 130068-27-8 (Interleukin-10)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170110
[Lr] Data última revisão:
170110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160414
[St] Status:MEDLINE


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[PMID]:27014852
[Au] Autor:Bigelow CA; Cinelli CM; Little SE; Benson CB; Frates MC; Wilkins-Haug LE
[Ad] Endereço:Brigham and Women's Hospital, Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Harvard Medical School, Boston, MA, United States. Electronic address: cbigelow@partners.org.
[Ti] Título:Percutaneous umbilical blood sampling: current trends and outcomes.
[So] Source:Eur J Obstet Gynecol Reprod Biol;200:98-101, 2016 May.
[Is] ISSN:1872-7654
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To report our contemporary experience with PUBS, including indications and complications, stratified by the presence of hydrops fetalis. STUDY DESIGN: All PUBS performed from 1988 to 2013 at a single tertiary care center were identified using a comprehensive ultrasound database. We recorded patient demographics, relevant obstetric, fetal and neonatal data, indication for and success of PUBS and any complications. Data were analyzed using SAS, version 9.3 (SAS Institute Inc., Cary, NC). RESULTS: 455 PUBS were performed on 208 pregnant women, 97.8% of which were successful. The average gestational age at the time of PUBS was 26.7 weeks (SD 5.1 weeks, range 17.5-41.3 weeks). Indications were available for 441: 245 (55.6%) isoimmunization, 77 (17.5%) non-immune hydrops fetalis (NIHF), 98 (22.2%) chromosomal diagnosis, and 21 (4.8%) other indications. Isoimmunization was a less common indication for PUBS in 2008-2013 as compared to 1988-1992 (51.7% vs 66.2%, p=0.07). Amongst PUBS performed in the setting of hydrops, isoimmunization was much less common in the later time period (61.1% vs 0%, respectively; p<0.01). The procedure complication rate (bradycardia or fetal demise at procedure) of 2.5% was stable over the study period and was most common with NIHF (2.0% without hydrops, 0% with immune hydrops and 6.3% with NIHF; p=0.04). Of the 208 women with a PUBS performed, 74 had more than one PUBS procedure (mean 2.2, max 18). Transfusions were performed in 233 of the 455 (51.2%). Overall, 10.2% of the pregnancies had an intrauterine fetal demise (IUFD) within 2 weeks of the procedure, which was most common in pregnancies with NIHF (3.2% without hydrops, 9.1% with immune hydrops and 31.7% with NIHF; p<0.01). The IUFD rate was 60% (3/5) in fetuses with parvovirus-mediated NIHF. CONCLUSIONS: PUBS has a high likelihood of success with a relatively low complication rate. The complication rate is highest in pregnancies with NIHF, and these pregnancies are also at a significantly higher risk of IUFD, particularly those patients with parvovirus-mediated NIHF. Our findings can be used when counseling patients who are considering PUBS for diagnostic or therapeutic purposes.
[Mh] Termos MeSH primário: Cordocentese/tendências
Diagnóstico Pré-Natal/métodos
[Mh] Termos MeSH secundário: Aberrações Cromossômicas
Cordocentese/efeitos adversos
Cordocentese/métodos
Feminino
Idade Gestacional
Seres Humanos
Hidropisia Fetal/diagnóstico
Gravidez
Resultado da Gravidez
Isoimunização Rh/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170217
[Lr] Data última revisão:
170217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160326
[St] Status:MEDLINE


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[PMID]:26749585
[Au] Autor:Pupillo D; Simonato M; Cogo PE; Lapillonne A; Carnielli VP
[Ad] Endereço:Division of Neonatology, Polytechnic University of Marche and Salesi's Children Hospital, Via Corridoni 11, 62123, Ancona, Italy.
[Ti] Título:Short-Term Stability of Whole Blood Polyunsaturated Fatty Acid Content on Filter Paper During Storage at -28 °C.
[So] Source:Lipids;51(2):193-8, 2016 Feb.
[Is] ISSN:1558-9307
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Finger or heel-pricked blood sampling for fatty acid analysis is suitable especially in newborn infants where blood sampling is difficult and phlebotomy for research can be unethical. The aim of this study was to evaluate dried blood long chain polyunsaturated fatty acids (LC-PUFA) stability during storage at -28 °C. We collected 12 blood cord samples that were analyzed immediately after blood drawing, with and without drying the blood on filter paper. Dried samples were then analyzed 7 days and 1, 3, and 6 months after collection. Butylated hydroxytoluene was added to all samples. Fatty acid composition and (13)C enrichment were measured by gas chromatography and by gas chromatography-isotope ratio mass spectrometry, respectively. The fatty acid composition, expressed in mol%, of the major LC-PUFA at day 7 was not statistically different from time 0, however lower values were found by the first month of storage. The (13)C enrichment of 20:4n-6 and 22:6n-3 did not differ during the whole study period. LC-PUFA analysis from dried umbilical cord blood in neonates should be performed within a week, major losses of LC-PUFA occur afterwards. However, fatty acids obtained from dried blood maintain their (13)C enrichment value for up to 6 months and thus these samples are suitable for natural abundance isotopic studies.
[Mh] Termos MeSH primário: Cordocentese/métodos
Ácidos Graxos Insaturados/química
Sangue Fetal/química
[Mh] Termos MeSH secundário: Hidroxitolueno Butilado/química
Radioisótopos de Carbono/química
Cromatografia Gasosa
Ácidos Docosa-Hexaenoicos/química
Teste em Amostras de Sangue Seco
Ácidos Graxos Insaturados/sangue
Seres Humanos
Recém-Nascido
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbon Radioisotopes); 0 (Fatty Acids, Unsaturated); 1P9D0Z171K (Butylated Hydroxytoluene); 25167-62-8 (Docosahexaenoic Acids)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:171105
[Lr] Data última revisão:
171105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160111
[St] Status:MEDLINE
[do] DOI:10.1007/s11745-015-4111-z


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[PMID]:26574185
[Au] Autor:Au PK; Kan AS; Tang MH; Leung KY; Chan KY; Tang TW; Lau ET
[Ad] Endereço:a Department of Obstetrics & Gynaecology , Queen Mary Hospital , Hong Kong SAR , People's Republic of China.
[Ti] Título:A Fetus with Hb Bart's Disease Due to Maternal Uniparental Disomy for Chromosome 16.
[So] Source:Hemoglobin;40(1):66-9, 2016.
[Is] ISSN:1532-432X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We here report an unusual case of Hb Bart's (γ4) disease. Thalassemia screening of a couple showed that the wife was an α(0)-thalassemia (α(0)-thal) carrier and her husband's mean corpuscular volume (MCV) was normal. Chorionic villus sampling (CVS) was performed at 13 weeks' gestation for positive Down syndrome screening and chromosomal study of the cultured CVS showed a normal karyotype. Ultrasound examination at 22 weeks' gestation showed fetal cardiomegaly and raised middle cerebral artery peak systolic velocity. Cordocentesis confirmed fetal anemia and showed Hb Bart's disease. Multiplex gap-polymerase chain reaction (gap-PCR) for α-thal deletions on DNA extracted from the CVS showed the presence of a homozygous α(0)-thal - -(SEA) (Southeast Asian) deletion. The husband was found to be a carrier of the α(+)-thal -α(3.7) (rightward) deletion. Non paternity was excluded by fluorescent PCR using short tandem repeat (STR) markers on chromosomes 13, 18 and 21. A de novo terminal deletion of chromosome 16 was excluded by array comparative genomic hybridization (aCGH). Detection of uniparental disomy (UPD), using STR markers on chromosome 16 showed maternal uniparental isodisomy from 16pter to 16p13.2, and uniparental heterodisomy from 16p13.13 to 16qter.
[Mh] Termos MeSH primário: Anemia/diagnóstico
Cromossomos Humanos Par 16/genética
Doenças Fetais/diagnóstico
Hemoglobinas Anormais/genética
Dissomia Uniparental/genética
[Mh] Termos MeSH secundário: Adulto
Anemia/genética
Amostra da Vilosidade Coriônica
Hibridização Genômica Comparativa
Cordocentese
Feminino
Doenças Fetais/genética
Seres Humanos
Masculino
Gravidez
Diagnóstico Pré-Natal
Deleção de Sequência
Talassemia alfa/genética
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hemoglobins, Abnormal); 9056-09-1 (hemoglobin Bart's)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151118
[St] Status:MEDLINE
[do] DOI:10.3109/03630269.2015.1096283



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