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[PMID]: 29177254 [Au] Autor: Liu M; Qin C; Xia X; Li M; Wang Y; Wang L; Shang X; Lan X [Ad] Endereço: Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. LXL730724@hotmail.com, sxsâ‚‹sxk@163.com. [Ti] Título: Semi-quantitative assessment of pulmonary arterial hypertension associated with congenital heart disease through myocardial perfusion imaging. [So] Source: Hell J Nucl Med;20(3):204-210, 2017 Sep-Dec. [Is] ISSN: 1790-5427 [Cp] País de publicação: Greece [La] Idioma: eng [Ab] Resumo: OBJECTIVE: The study aimed to use myocardial perfusion imaging (MPI) as a semi-quantitative method to assess the clinical severity of pulmonary arterial hypertension (PAH) in patients with congenital heart disease (CHD). SUBJECTS AND METHODS: A total of 24 patients with PAH related to CHD (PAH-CHD) who received interventional or medical treatment were included. All patients underwent physical examination, cardiac function evaluation, biochemical test, echocardiography, right heart catheterization (RHC), and MPI with Tc-methoxyisobutyl isonitrile ( Tc-MIBI) pre and 6 months post treatments. The correlation between MPI target/background (T/B) ratios and other variables were calculated. The receiver operating characteristic (ROC) curves were developed to evaluate the diagnostic value of T/B ratios. RESULTS: Most of the cardiac functional parameters, surplus pulse O (SPO ), biochemical values and right heart catheterization parameters were found significantly elevated after treatment (P<0.05). Pre-treatment MPI showed that T/B ratio had strong correlations with SPO , Borg scale, cardiac output (CO), cardiac index (CI), right ventricular stroke volume (RV-SV), pulmonary artery pressure (PAP), total pulmonary resistance (TPR), total pulmonary resistance index (TPRI), pulmonary vascular resistance (PVR), and pulmonary vascular resistance index (PVRI). After 6 months treatment, the correlation between T/B ratios and most of these parameters measured were reduced. Receiver operating characteristics curves showed that the diagnostic performance of MPI T/B ratio in moderate/severe PAH patients was significant. The area under the curve (AUC) when measured pre-treatment was 0.929 (P=0.002) and reduced to 0.800 (P=0.046) at post-treatment. CONCLUSION: Semi-quantitative MPI has high diagnostic value in evaluating the severity level of pulmonary arterial hypertension in patients with congenital heart disease. The diagnostic performance of MPI at pre-treatment patients was superior to that at post-treatment. More cases need to be included for further study. [Mh] Termos MeSH primário: Cardiopatias Congênitas/diagnóstico por imagem Hipertensão Pulmonar/diagnóstico por imagem Interpretação de Imagem Assistida por Computador/métodos Imagem de Perfusão do Miocárdio/métodos Tecnécio Tc 99m Sestamibi Tomografia Computadorizada de Emissão de Fóton Único/métodos [Mh] Termos MeSH secundário: Adolescente Adulto Meios de Contraste Feminino Cardiopatias Congênitas/complicações Seres Humanos Hipertensão Pulmonar/etiologia Masculino Reprodutibilidade dos Testes Sensibilidade e Especificidade Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Contrast Media); 971Z4W1S09 (Technetium Tc 99m Sestamibi) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180223 [Lr] Data última revisão: 180223 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171128 [St] Status: MEDLINE [do] DOI: 10.1967/s002449910600

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[PMID]: 28461279 [Au] Autor: Yao A; Balchandani P; Shrivastava RK [Ad] Endereço: Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, New York, New York, USA. [Ti] Título: Metabolic In Vivo Visualization of Pituitary Adenomas: a Systematic Review of Imaging Modalities. [So] Source: World Neurosurg;104:489-498, 2017 Aug. [Is] ISSN: 1878-8769 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: OBJECTIVE: Pituitary adenomas (PAs) are the most common intrasellar mass. Functional PAs constitute most of pituitary tumors and can produce symptoms related to hormonal overproduction. Timely and accurate detection is therefore of vital importance to prevent potentially irreversible sequelae. Magnetic resonance imaging is the gold standard for detecting PAs, but is limited by poor sensitivity for microadenomas and an inability to differentiate scar tissue from tumor residual or predict treatment response. Several new modalities that detect PAs have been proposed. METHODS: A systematic review of the PubMed database was performed for imaging studies of PAs since its inception. Data concerning study characteristics, clinical symptoms, imaging modalities, and diagnostic accuracy were collected. RESULTS: After applying exclusion criteria, 25 studies of imaging PAs using positron emission tomography (PET), magnetic resonance spectroscopy (MRS), and single photon emission computed tomography were reviewed. PET reliably detects PAs, particularly where magnetic resonance imaging is equivocal, although its efficacy is limited by high cost and low availability. Single photon emission computed tomography possesses good sensitivity for neuroendocrine tumors but its use with PAs is poorly documented. MRS consistently detects cellular proliferation and hormonal activity, but warrants further study at higher magnetic field strength. CONCLUSIONS: PET and MRS appear to have the strongest predictive value in detecting PAs. MRS has the advantage of low cost, but the literature is lacking in specific studies of the pituitary. Due to high recurrence rates of functional PAs and low sensitivity of existing diagnostic workups, further investigation of metabolic imaging is necessary. [Mh] Termos MeSH primário: Adenoma/diagnóstico por imagem Adenoma/metabolismo Hormônios Ectópicos/metabolismo Neuroimagem/métodos Hormônios Hipofisários/metabolismo Neoplasias Hipofisárias/diagnóstico por imagem Neoplasias Hipofisárias/metabolismo [Mh] Termos MeSH secundário: Adenoma/cirurgia Seres Humanos Imagem Tridimensional Imagem por Ressonância Magnética Espectroscopia de Ressonância Magnética Neoplasias Hipofisárias/cirurgia Tomografia por Emissão de Pósitrons Sensibilidade e Especificidade Tomografia Computadorizada de Emissão de Fóton Único Tomografia Computadorizada por Raios X [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Hormones, Ectopic); 0 (Pituitary Hormones) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 180222 [Lr] Data última revisão: 180222 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170503 [St] Status: MEDLINE

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[PMID]: 29390491 [Au] Autor: Jang SH; Seo JP [Ad] Endereço: Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daemyungdong, Namku, Taegu, Republic of Korea. [Ti] Título: Absent-mindedness and injury of the ascending reticular activating system in a patient with mild traumatic brain injury: A case report. [So] Source: Medicine (Baltimore);96(51):e9289, 2017 Dec. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: RATIONALE: No study on the association of absent-mindedness and injury of the ascending reticular activating system (ARAS) has been reported. We report on a patient who showed absent-mindedness and injury of the ARAS following mild traumatic brain injury. PATIENT CONCERNS: The patient complained of absent-mindedness since the head trauma, which was mainly observed while dining for several (5-10) minutes approximately 3 to 4 times a day: according to the patient's family, he usually stopped eating while holding the spoon in the air for approximately 5∼10 minutes. DIAGNOSES: A 19-year-old man suffered from head trauma resulting from being hit on his head by a falling glass from a large window (1.5 × 2 m, approximately 100 kg) at a cafe. INTERVENTIONS: His absent-mindedness showed slow improvement with the passage of time and had almost disappeared at seven months after onset. OUTCOMES: The lower portion of both lower dorsal ARAS and the upper portion of the left lower ventral ARAS of the patient were thinner, and partial tearing was observed in the right lower ventral ARAS. Decreased neural connectivity of the intralaminar thalamic nucleus to the prefrontal cortex, basal forebrain, parietal cortex, and occipital cortex was detected in both hemispheres. LESSONS: Injury of the ARAS and injury of the cerebral cortex was demonstrated in a patient with absent-mindedness following mild traumatic brain injury. The absent-mindedness in this patient might be related to the injury of the ARAS. [Mh] Termos MeSH primário: Concussão Encefálica/complicações Traumatismos Craniocerebrais/complicações Núcleos Intralaminares do Tálamo/lesões Transtornos da Memória/etiologia [Mh] Termos MeSH secundário: Concussão Encefálica/diagnóstico Córtex Cerebral/lesões Traumatismos Craniocerebrais/diagnóstico por imagem Seguimentos Seres Humanos Escala de Gravidade do Ferimento Masculino Transtornos da Memória/fisiopatologia Testes Neuropsicológicos Índice de Gravidade de Doença Fatores de Tempo Tomografia Computadorizada de Emissão de Fóton Único/métodos Adulto Jovem [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180214 [Lr] Data última revisão: 180214 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180203 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000009289

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[PMID]: 29216309 [Au] Autor: Lee SK; Jung JI; O JH; Kim HW; Youn HJ [Ad] Endereço: Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. [Ti] Título: Coronary-to-pulmonary artery fistula in adults: Evaluation with thallium-201 myocardial perfusion SPECT. [So] Source: PLoS One;12(12):e0189269, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: OBJECTIVES: With the increasing use of multi-detector CT, the number of detected cases with coronary-to-pulmonary artery fistula (CPAF) has increased. Several previous studies reported severe cases of angina, but no appropriate tests to evaluate myocardial perfusion for patients with CPAF have been established. We evaluated the hemodynamic characteristics of CPAF using thallium-201 (Tl-201) single photon emission computed tomography (SPECT). MATERIALS AND METHODS: Tl-201 SPECT was performed in 17 patients with CPAF, but without evidence of coronary artery disease on coronary computed tomography angiography (CCTA) (age, 58.5±13.3 years; 8 men). Quantitative analysis of scintigraphic data was performed. Additionally, perfusion abnormalities were compared with CCTA findings. Medical records were obtained to define clinical data, diagnostic findings, symptoms, management, follow-up data, and major adverse cardiac events (MACE). RESULTS: Six patients (35.2%) showed perfusion abnormalities on SPECT studies and could be classified as follows: 3 patients, no reversible ischemia (3/17, 17.6%); 1 patient, mild ischemia (1/17, 5.8%); and 2 patients, moderate ischemia (2/17, 11.7%). During the follow-up, ten patients (58.8%) improved under medical management and 5 patients (29.4%) underwent surgical ligation for CPAF with symptomatic improvement in 4 patients. Seven patients performed follow-up myocardial perfusion SPECT, and symptomatic improvement correlated well with scintigraphic perfusion improvement in 6 patients No MACE was observed. CLINICAL SIGNIFICANCE: Tl-201 myocardial perfusion SPECT might be useful for determining the hemodynamic status and for risk stratification in patients with CPAF. [Mh] Termos MeSH primário: Fístula/diagnóstico por imagem Artéria Pulmonar/patologia Radioisótopos de Tálio/administração & dosagem [Mh] Termos MeSH secundário: Adulto Idoso Fístula/fisiopatologia Fístula/cirurgia Seguimentos Seres Humanos Masculino Artéria Pulmonar/diagnóstico por imagem Artéria Pulmonar/fisiopatologia Tomografia Computadorizada de Emissão de Fóton Único Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Thallium Radioisotopes); 0 (Thallium-201) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180206 [Lr] Data última revisão: 180206 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171208 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0189269

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[PMID]: 28458607 [Au] Autor: Kim HJ; Bang JI; Kim JY; Moon JH; So Y; Lee WW [Ad] Endereço: Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 13620, Korea. [Ti] Título: Novel Application of Quantitative Single-Photon Emission Computed Tomography/Computed Tomography to Predict Early Response to Methimazole in Graves' Disease. [So] Source: Korean J Radiol;18(3):543-550, 2017 May-Jun. [Is] ISSN: 2005-8330 [Cp] País de publicação: Korea (South) [La] Idioma: eng [Ab] Resumo: OBJECTIVE: Since Graves' disease (GD) is resistant to antithyroid drugs (ATDs), an accurate quantitative thyroid function measurement is required for the prediction of early responses to ATD. Quantitative parameters derived from the novel technology, single-photon emission computed tomography/computed tomography (SPECT/CT), were investigated for the prediction of achievement of euthyroidism after methimazole (MMI) treatment in GD. MATERIALS AND METHODS: A total of 36 GD patients (10 males, 26 females; mean age, 45.3 ± 13.8 years) were enrolled for this study, from April 2015 to January 2016. They underwent quantitative thyroid SPECT/CT 20 minutes post-injection of Tc-pertechnetate (5 mCi). Association between the time to biochemical euthyroidism after MMI treatment and %uptake, standardized uptake value (SUV), functional thyroid mass (SUVmean × thyroid volume) from the SPECT/CT, and clinical/biochemical variables, were investigated. RESULTS: GD patients had a significantly greater %uptake (6.9 ± 6.4%) than historical control euthyroid patients (n = 20, 0.8 ± 0.5%, < 0.001) from the same quantitative SPECT/CT protocol. Euthyroidism was achieved in 14 patients at 156 ± 62 days post-MMI treatment, but 22 patients had still not achieved euthyroidism by the last follow-up time-point (208 ± 80 days). In the univariate Cox regression analysis, the initial MMI dose ( = 0.014), %uptake ( = 0.015), and functional thyroid mass ( = 0.016) were significant predictors of euthyroidism in response to MMI treatment. However, only %uptake remained significant in a multivariate Cox regression analysis ( = 0.034). A %uptake cutoff of 5.0% dichotomized the faster responding versus the slower responding GD patients ( = 0.006). CONCLUSION: A novel parameter of thyroid %uptake from quantitative SPECT/CT is a predictive indicator of an early response to MMI in GD patients. [Mh] Termos MeSH primário: Doença de Graves/diagnóstico por imagem Tomografia Computadorizada de Emissão de Fóton Único [Mh] Termos MeSH secundário: Adulto Antitireóideos/uso terapêutico Feminino Doença de Graves/tratamento farmacológico Doença de Graves/patologia Seres Humanos Masculino Metimazol/uso terapêutico Meia-Idade Modelos de Riscos Proporcionais Pertecnetato Tc 99m de Sódio/química Tireotropina/análise [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Antithyroid Agents); 554Z48XN5E (Methimazole); 9002-71-5 (Thyrotropin); A0730CX801 (Sodium Pertechnetate Tc 99m) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 180102 [Lr] Data última revisão: 180102 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170502 [St] Status: MEDLINE [do] DOI: 10.3348/kjr.2017.18.3.543

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[PMID]: 28458600 [Au] Autor: Chung HW; Ko SM; Hwang HK; So Y; Yi JG; Lee EJ [Ad] Endereço: Department of Nuclear Medicine, Konkuk University Medical Center, Research Institute of Biomedical Science, Konkuk University School of Medicine, Seoul 05030, Korea. [Ti] Título: Diagnostic Performance of Coronary CT Angiography, Stress Dual-Energy CT Perfusion, and Stress Perfusion Single-Photon Emission Computed Tomography for Coronary Artery Disease: Comparison with Combined Invasive Coronary Angiography and Stress Perfusion Cardiac MRI. [So] Source: Korean J Radiol;18(3):476-486, 2017 May-Jun. [Is] ISSN: 2005-8330 [Cp] País de publicação: Korea (South) [La] Idioma: eng [Ab] Resumo: OBJECTIVE: To investigate the diagnostic performance of coronary computed tomography angiography (CCTA), stress dual-energy computed tomography perfusion (DE-CTP), stress perfusion single-photon emission computed tomography (SPECT), and the combinations of CCTA with myocardial perfusion imaging (CCTA + DE-CTP and CCTA + SPECT) for identifying coronary artery stenosis that causes myocardial hypoperfusion. Combined invasive coronary angiography (ICA) and stress perfusion cardiac magnetic resonance (SP-CMR) imaging are used as the reference standard. MATERIALS AND METHODS: We retrospectively reviewed the records of 25 patients with suspected coronary artery disease, who underwent CCTA, DE-CTP, SPECT, SP-CMR, and ICA. The reference standard was defined as ≥ 50% stenosis by ICA, with a corresponding myocardial hypoperfusion on SP-CMR. RESULTS: For per-vascular territory analysis, the sensitivities of CCTA, DE-CTP, SPECT, CCTA + DE-CTP, and CCTA + SPECT were 96, 96, 68, 93, and 68%, respectively, and specificities were 72, 75, 89, 85, and 94%, respectively. The areas under the receiver operating characteristic curve (AUCs) were 0.84 ± 0.05, 0.85 ± 0.05, 0.79 ± 0.06, 0.89 ± 0.04, and 0.81 ± 0.06, respectively. For per-patient analysis, the sensitivities of CCTA, DE-CTP, SPECT, CCTA + DE-CTP, and CCTA + SPECT were 100, 100, 89, 100, and 83%, respectively; the specificities were 14, 43, 57, 43, and 57%, respectively; and the AUCs were 0.57 ± 0.13, 0.71 ± 0.11, 0.73 ± 0.11, 0.71 ± 0.11, and 0.70 ± 0.11, respectively. CONCLUSION: The combination of CCTA and DE-CTP enhances specificity without a loss of sensitivity for detecting hemodynamically significant coronary artery stenosis, as defined by combined ICA and SP-CMR. [Mh] Termos MeSH primário: Angiografia por Tomografia Computadorizada Doença da Artéria Coronariana/diagnóstico por imagem Imagem de Perfusão do Miocárdio Tomografia Computadorizada de Emissão de Fóton Único [Mh] Termos MeSH secundário: Idoso Área Sob a Curva Doença da Artéria Coronariana/patologia Feminino Hemodinâmica Seres Humanos Masculino Meia-Idade Curva ROC Estudos Retrospectivos Sensibilidade e Especificidade [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 180102 [Lr] Data última revisão: 180102 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170502 [St] Status: MEDLINE [do] DOI: 10.3348/kjr.2017.18.3.476

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[PMID]: 29190653 [Au] Autor: Hakimzadeh N; Pinas VA; Molenaar G; de Waard V; Lutgens E; van Eck-Smit BLF; de Bruin K; Piek JJ; Eersels JLH; Booij J; Verberne HJ; Windhorst AD [Ad] Endereço: Department of Biomedical Engineering & Physics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. [Ti] Título: Novel molecular imaging ligands targeting matrix metalloproteinases 2 and 9 for imaging of unstable atherosclerotic plaques. [So] Source: PLoS One;12(11):e0187767, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Molecular imaging of matrix metalloproteinases (MMPs) may allow detection of atherosclerotic lesions vulnerable to rupture. In this study, we develop a novel radiolabelled compound that can target gelatinase MMP subtypes (MMP2/9) with high selectivity and inhibitory potency. Inhibitory potencies of several halogenated analogues of MMP subtype-selective inhibitors (N-benzenesulfonyliminodiacetyl monohydroxamates and N-halophenoxy-benzenesulfonyl iminodiacetyl monohydroxamates) were in the nanomolar range for MMP2/9. The analogue with highest inhibitory potency and selectivity was radiolabelled with [123I], resulting in moderate radiochemical yield, and high radiochemical purity. Biodistribution studies in mice, revealed stabilization in blood 1 hour after intravenous bolus injection. Intravenous infusion of the radioligand and subsequent autoradiography of excised aortas showed tracer uptake in atheroprone mice. Distribution of the radioligand showed co-localization with MMP2/9 immunohistochemical staining. In conclusion, we have developed a novel selective radiolabeled MMP2/9 inhibitor, suitable for single photon emission computed tomography (SPECT) imaging that effectively targets atherosclerotic lesions in mice. [Mh] Termos MeSH primário: Metaloproteinase 2 da Matriz/metabolismo Metaloproteinase 9 da Matriz/metabolismo Placa Aterosclerótica/diagnóstico por imagem [Mh] Termos MeSH secundário: Animais Feminino Ligantes Espectroscopia de Ressonância Magnética Camundongos Camundongos Endogâmicos C57BL Ensaio Radioligante Distribuição Tecidual Tomografia Computadorizada de Emissão de Fóton Único [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Ligands); EC 3.4.24.24 (Matrix Metalloproteinase 2); EC 3.4.24.35 (Matrix Metalloproteinase 9) [Em] Mês de entrada: 1712 [Cu] Atualização por classe: 171226 [Lr] Data última revisão: 171226 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171201 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0187767

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[PMID]: 29189860 [Au] Autor: Paillahueque G; Massardo T; Barberán M; Ocares G; Gallegos I; Toro L; Araya AV [Ad] Endereço: Sección Medicina Nuclear, Hospital Clínico, Universidad de Chile, Santiago, Chile. [Ti] Título: [False negative spect parathyroid scintigraphy with sestamibi in patients with primary hyperparathyroidism]. [Ti] Título: Análisis de falsos negativos en la cintigrafía SPECT de paratiroides con sestamibi en pacientes con hiperparatiroidismo primario sometidos a cirugía entre 2008-2015 en hospital universitario.. [So] Source: Rev Med Chil;145(8):1021-1027, 2017 Aug. [Is] ISSN: 0717-6163 [Cp] País de publicação: Chile [La] Idioma: spa [Ab] Resumo: BACKGROUND: 99mTc-sestamibi parathyroid SPECT scintigraphy is a useful tool in the pre-operative study of hyperparathyroidism. False negatives (FN) have been reported in 5.7-14% of the examinations. AIM: To characterize 99mTc-sestamibi FN in cases referred for primary hyperparathyroidism (PHP) to a university hospital. MATERIAL AND METHODS: Descriptive retrospective analysis. We included patients with PHP, studied with SPECT scintigraphy, operated at our center between 2008 and 2015. Clinical and surgical data were recorded; biopsies of the FN were blindly reviewed by one pathologist. RESULTS: One hundred twenty one scintigraphies fulfilled the inclusion criteria. Seven (5.8%) were negative and 114 positive. There was no difference in age, sex and PTH levels between FN and true positive scintigraphies. At surgery, one FN case had two hyperplasic glands and two cases had ectopic glands. Pathology reported adenoma in three cases, hyperplasia in three and carcinoma in one. The largest diameter of the lesion was lower in FN (1.3 and 2.1 cm respectively, p = 0.02) and the proportion of adenomas was higher in true positive cases (29% and 75% respectively; p < 0.01). The interval between scintigraphy and parathyroidectomy was greater in FN with a median of 92 days (range 20 days-3.2 years, p < 0.01). The percentage of oxyphilic cells observed was similar in both groups. CONCLUSIONS: FN parathyroid SPECT scintigraphies in PHP are uncommon. They corresponded to lesions under the equipment's resolution limit and resulted in longer time lags between scintigraphy and surgery. [Mh] Termos MeSH primário: Hiperparatireoidismo Primário/diagnóstico por imagem Glândulas Paratireoides/diagnóstico por imagem Compostos Radiofarmacêuticos Tecnécio Tc 99m Sestamibi Tomografia Computadorizada de Emissão de Fóton Único/métodos [Mh] Termos MeSH secundário: Adenoma/diagnóstico por imagem Adenoma/patologia Adulto Idoso Carcinoma/diagnóstico por imagem Carcinoma/patologia Reações Falso-Negativas Feminino Seres Humanos Hiperparatireoidismo Primário/patologia Hiperplasia/diagnóstico por imagem Hiperplasia/patologia Masculino Meia-Idade Glândulas Paratireoides/patologia Neoplasias das Paratireoides/diagnóstico por imagem Neoplasias das Paratireoides/patologia Padrões de Referência Valores de Referência Estudos Retrospectivos Estatísticas não Paramétricas [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Radiopharmaceuticals); 971Z4W1S09 (Technetium Tc 99m Sestamibi) [Em] Mês de entrada: 1712 [Cu] Atualização por classe: 171218 [Lr] Data última revisão: 171218 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171201 [St] Status: MEDLINE

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[PMID]: 29053782 [Au] Autor: Gaxiola-Valdez I; Singh S; Perera T; Sandy S; Li E; Federico P [Ad] Endereço: Hotchkiss Brain Institute, University of Calgary, Calgary, Canada. [Ti] Título: Seizure onset zone localization using postictal hypoperfusion detected by arterial spin labelling MRI. [So] Source: Brain;140(11):2895-2911, 2017 Nov 01. [Is] ISSN: 1460-2156 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Neurological dysfunction following epileptic seizures is a well-recognized phenomenon. Several potential mechanisms have been suggested to explain postictal dysfunction, with alteration in cerebral blood flow being one possibility. These vascular disturbances may be long lasting and localized to brain areas involved in seizure generation and propagation, as supported by both animal and human studies. Therefore, measuring perfusion changes in the postictal period may help localize the seizure onset zone. Arterial spin labelling is a non-invasive, rapid and reproducible magnetic resonance imaging technique that measures cerebral perfusion. To this end, we measured postictal perfusion in patients with drug resistant focal epilepsy who were admitted to our seizure-monitoring unit for presurgical evaluation. Twenty-one patients were prospectively recruited and underwent arterial spin labelling scanning within 90 min of a habitual seizure. Patients also underwent a similar scan in the interictal period, after they were seizure-free for at least 24 h. The acquired scans were subtracted to identify the areas of significant postictal hypoperfusion. The location of the maximal hypoperfusion was compared to the presumed seizure onset zone to assess for concordance. Also, the localizing value of this technique was compared to other structural and functional imaging modalities. Postictal perfusion reductions of >15 units (ml/100 g/l) were seen in 15/21 patients (71.4%). In 12/15 (80%) of these patients, the location of the hypoperfusion was partially or fully concordant with the location of the presumed seizure onset zone. This technique compared favourably to other neuroimaging modalities, being similar or superior to structural magnetic resonance imaging in 52% of cases, ictal single-photon emission computed tomography in 60% of cases and interictal positron emission tomography in 71% of cases. Better arterial spin labelling results were obtained in patients in whom the seizure onset zone was discernible based on non-invasive data. Thus, this technique is a safe, non-invasive and relatively inexpensive tool to detect postictal hypoperfusion that may provide useful data to localize the seizure onset zone. This technique may be incorporated into the battery of conventional investigations for presurgical evaluation of patients with drug resistant focal epilepsy. [Mh] Termos MeSH primário: Encéfalo/diagnóstico por imagem Epilepsia Resistente a Medicamentos/diagnóstico por imagem Epilepsias Parciais/diagnóstico por imagem [Mh] Termos MeSH secundário: Adulto Encéfalo/irrigação sanguínea Mapeamento Encefálico Circulação Cerebrovascular Eletroencefalografia Feminino Seres Humanos Angiografia por Ressonância Magnética Imagem por Ressonância Magnética Masculino Meia-Idade Tomografia por Emissão de Pósitrons Estudos Prospectivos Convulsões/diagnóstico por imagem Tomografia Computadorizada de Emissão de Fóton Único Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171107 [Lr] Data última revisão: 171107 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 171021 [St] Status: MEDLINE [do] DOI: 10.1093/brain/awx241

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[PMID]: 29030452 [Au] Autor: Mollenhauer B; Caspell-Garcia CJ; Coffey CS; Taylor P; Shaw LM; Trojanowski JQ; Singleton A; Frasier M; Marek K; Galasko D; Parkinson's Progression Marker Initiative [Ad] Endereço: From the Department of Neurology (B.M.), University Medical Center, Göttingen; Paracelsus-Elena-Klinik (B.M.), Kassel, Germany; Department of Biostatistics (C.J.C.-G., C.S.C.), College of Public Health, University of Iowa, Iowa City; BioLegend Inc. (P.T.), San Diego, CA; Department of Pathology & [Ti] Título: Longitudinal CSF biomarkers in patients with early Parkinson disease and healthy controls. [So] Source: Neurology;89(19):1959-1969, 2017 Nov 07. [Is] ISSN: 1526-632X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: OBJECTIVE: To analyze longitudinal levels of CSF biomarkers in drug-naive patients with Parkinson disease (PD) and healthy controls (HC), examine the extent to which these biomarker changes relate to clinical measures of PD, and identify what may influence them. METHODS: CSF α-synuclein (α-syn), total and phosphorylated tau (t- and p-tau), and ß-amyloid 1-42 (Aß42) were measured at baseline and 6 and 12 months in 173 patients with PD and 112 matched HC in the international multicenter Parkinson's Progression Marker Initiative. Baseline clinical and demographic variables, PD medications, neuroimaging, and genetic variables were evaluated as potential predictors of CSF biomarker changes. RESULTS: CSF biomarkers were stable over 6 and 12 months, and there was a small but significant increase in CSF Aß42 in both patients with patients with PD and HC from baseline to 12 months. The t-tau remained stable. The p-tau increased marginally more in patients with PD than in HC. α-syn remained relatively stable in patients with PD and HC. Ratios of p-tau/t-tau increased, while t-tau/Aß42 decreased over 12 months in patients with PD. CSF biomarker changes did not correlate with changes in Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale motor scores or dopamine imaging. CSF α-syn levels at 12 months were lower in patients with PD treated with dopamine replacement therapy, especially dopamine agonists. CONCLUSIONS: These core CSF biomarkers remained stable over 6 and 12 months in patients with early PD and HC. PD medication use may influence CSF α-syn. Novel biomarkers are needed to better profile progressive neurodegeneration in PD. [Mh] Termos MeSH primário: Peptídeos beta-Amiloides/líquido cefalorraquidiano Doença de Parkinson/líquido cefalorraquidiano Fragmentos de Peptídeos/líquido cefalorraquidiano Proteínas tau/líquido cefalorraquidiano [Mh] Termos MeSH secundário: Idoso Apolipoproteínas E/genética Estudos de Casos e Controles Dopamina/metabolismo Feminino Seres Humanos Estudos Longitudinais Masculino Meia-Idade Doença de Parkinson/diagnóstico por imagem Doença de Parkinson/genética Polimorfismo de Nucleotídeo Único/genética Estudos Retrospectivos Índice de Gravidade de Doença Fatores de Tempo Tomografia Computadorizada de Emissão de Fóton Único [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Amyloid beta-Peptides); 0 (Apolipoproteins E); 0 (Peptide Fragments); 0 (amyloid beta-protein (1-42)); 0 (tau Proteins); VTD58H1Z2X (Dopamine) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171115 [Lr] Data última revisão: 171115 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 171015 [St] Status: MEDLINE [do] DOI: 10.1212/WNL.0000000000004609

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