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[PMID]:28854186
[Au] Autor:Tao Y; Xu C; Yuan C; Wang H; Lin B; Zhuo K; Liao J
[Ad] Endereço:Laboratory of Plant Nematology, South China Agricultural University, Guangzhou, China.
[Ti] Título:Meloidogyne aberrans sp. nov. (Nematoda: Meloidogynidae), a new root-knot nematode parasitizing kiwifruit in China.
[So] Source:PLoS One;12(8):e0182627, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:High infection rates of roots of wild kiwifruit (Actinidia chinensis Planch) and soil infestation by a root-knot nematode were found in Anshun, GuiZhou Province, China. Morphology, esterase phenotype and molecular analyses confirmed that this nematode was different from previously described root-knot nematodes. In this report, the species is described, illustrated and named Meloidogyne aberrans sp. nov. The new species has a unique combination of characters. A prominent posterior protuberance, round and faint perineal pattern and a medium-length stylet (13.6-15.5 µm) characterized the females. Second-stage juveniles (J2) were characterized by a smooth lip region with distinctly protruded medial lips and a depression in outline at the oral aperture, a relatively long stylet (15.9-16.8 µm), four incisures in the lateral field and a very short, even poorly defined, hyaline tail terminus (2.2-5.5 µm). More incisures (11-15) existed in the lateral field of males, and the stylet and spicules of males were 18.2-19.6 µm and 22.7-36.8 µm long respectively. Egg masses were typically produced within the roots of kiwifruit. The new species had a rare Est phenotype, S2. Phylogenetic trees inferred from SSU, LSU D2D3, ITS, and partial coxII-16S rRNA revealed that M. aberrans sp. nov. was within the Meloidogyne clade and was distinguished from all described root-knot nematodes. Moreover, from histopathological observations, M. aberrans sp. nov. induced the formation of multinucleate giant cells.
[Mh] Termos MeSH primário: Actinidia/parasitologia
Doenças das Plantas/parasitologia
Raízes de Plantas/parasitologia
Tylenchoidea/fisiologia
[Mh] Termos MeSH secundário: Animais
China
Feminino
Masculino
Microscopia Eletrônica de Varredura
Fotomicrografia
Filogenia
RNA Ribossômico 16S/genética
Tylenchoidea/genética
Tylenchoidea/ultraestrutura
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182627


  2 / 3410 MEDLINE  
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[PMID]:28734427
[Au] Autor:Samura T; Toda K; Yoshioka D; Nakamura T; Miyagawa S; Yoshikawa Y; Saito S; Domae K; Sawa Y
[Ad] Endereço:Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
[Ti] Título:Libman-Sacks Endocarditis Due to Systemic Lupus Erythematosus Activation After Mitral Valve Plasty.
[So] Source:Ann Thorac Surg;104(2):e109-e111, 2017 Aug.
[Is] ISSN:1552-6259
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Libman-Sacks endocarditis is a cardiac manifestation of systemic lupus erythematosus (SLE) and antiphospholipid syndrome. We report a case of mitral valve destruction due to Libman-Sacks endocarditis, which was caused by activation of SLE, despite prompt initiation of systemic steroid therapy. The prevention of SLE activation is critically important in valve surgery for patients with SLE. To the best of our knowledge, this is the first case of repaired mitral valve destruction due to activation of SLE, which was caused by valve surgery itself.
[Mh] Termos MeSH primário: Síndrome Antifosfolipídica/complicações
Endocardite/etiologia
Implante de Prótese de Valva Cardíaca/efeitos adversos
Lúpus Eritematoso Sistêmico/complicações
Insuficiência da Valva Mitral/cirurgia
Valva Mitral/cirurgia
[Mh] Termos MeSH secundário: Síndrome Antifosfolipídica/diagnóstico
Biópsia
Endocardite/diagnóstico
Feminino
Seres Humanos
Lúpus Eritematoso Sistêmico/diagnóstico
Meia-Idade
Insuficiência da Valva Mitral/diagnóstico
Insuficiência da Valva Mitral/etiologia
Fotomicrografia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170724
[St] Status:MEDLINE


  3 / 3410 MEDLINE  
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[PMID]:28643724
[Au] Autor:Philip SS; Kuriakose T; Chacko G
[Ad] Endereço:Department of Ophthalmology, Christian Medical College and Hospital, Vellore, Tamil Nadu, South India.
[Ti] Título:Successful surgical management of bilateral epiretinal membrane in a child with only café-au-lait spots.
[So] Source:Indian J Ophthalmol;65(6):531-533, 2017 Jun.
[Is] ISSN:1998-3689
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:A 6-year-old boy diagnosed as anisometropic amblyopia, with only café-au-lait spots and a family history of neurofibromatosis, presented with decrease in vision in the both eyes. Dilated fundus examination showed epiretinal membrane in both eyes over the macula. He underwent successful surgical management of the epiretinal membrane.
[Mh] Termos MeSH primário: Manchas Café com Leite/complicações
Membrana Epirretiniana/cirurgia
Macula Lutea/patologia
Retina/patologia
Acuidade Visual
Vitrectomia/métodos
[Mh] Termos MeSH secundário: Criança
Membrana Epirretiniana/complicações
Membrana Epirretiniana/diagnóstico
Seres Humanos
Masculino
Fotomicrografia
Tomografia de Coerência Óptica
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170624
[St] Status:MEDLINE
[do] DOI:10.4103/ijo.IJO_649_16


  4 / 3410 MEDLINE  
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[PMID]:28436246
[Au] Autor:Kaya S; Paparella MM; Cureoglu S
[Ad] Endereço:1 Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, USA.
[Ti] Título:Histopathologic Changes of Human Vestibular Epithelia in Intralabyrinthine Hemorrhage.
[So] Source:Ann Otol Rhinol Laryngol;126(6):445-450, 2017 Jun.
[Is] ISSN:1943-572X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To determine whether intralabyrinthine hemorrhage affects vestibular hair cells, dark cells, and transitional cells in human temporal bones. METHODS: We examined 9 temporal bone specimens from 9 deceased donors with unilateral intralabyrinthine hemorrhage (the hemorrhage group) along with their 9 contralateral temporal bone specimens without hemorrhage (the control group). We estimated the density of type I and type II hair cells in all peripheral sensorial organs (including the cristae of the superior, lateral, and posterior semicircular canals, as well as the maculae of the saccule and utricle). We also estimated the density of dark and transitional cells in the lateral and posterior semicircular canals. RESULTS: The loss of type I hair cells in the cristae of the superior, lateral, and posterior semicircular canals and in the maculae of the saccule and utricle was significantly higher in the hemorrhage group, as compared with the control group ( P < .05). The density of type II hair cells in the cristae of the superior and posterior canals and in the macula of the saccule significantly differed between the hemorrhage group and the control group ( P < .05). CONCLUSION: The loss of vestibular hair cells might be the cause of vestibular symptoms in patients with intralabyrinthine hemorrhage.
[Mh] Termos MeSH primário: Células Epiteliais/patologia
Células Ciliadas Vestibulares/patologia
Hemorragia/patologia
Doenças do Labirinto/patologia
Osso Temporal/patologia
Vestíbulo do Labirinto/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Feminino
Seres Humanos
Masculino
Meia-Idade
Fotomicrografia
Canais Semicirculares/patologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170425
[St] Status:MEDLINE
[do] DOI:10.1177/0003489417700646


  5 / 3410 MEDLINE  
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[PMID]:28395299
[Au] Autor:Zhao J; Kim HJ; Sparrow JR
[Ad] Endereço:Department of Ophthalmology, Columbia University Medical Center, New York, New York, United States.
[Ti] Título:Multimodal Fundus Imaging of Sodium Iodate-Treated Mice Informs RPE Susceptibility and Origins of Increased Fundus Autofluorescence.
[So] Source:Invest Ophthalmol Vis Sci;58(4):2152-2159, 2017 Apr 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: By multimodal imaging, and the use of mouse and in vitro models, we have addressed changes in fundus autofluorescence (488 and 790 nm) and observed interactions between the photooxidative stress imposed by RPE bisretinoid lipofuscin and the oxidative impact of systemic sodium iodate (NaIO3). Methods: Abca4-/-, wild-type, and Rpe65rd12 mice were given systemic injections of NaIO3 (30 mg/kg). Analysis included noninvasive imaging of fundus autofluorescence (short-wavelength [SW-AF]; near-infrared excitation [NIR-AF]), quantitative fundus AF (qAF; 488 nm); light microscopy, RPE flat-mounts and measurements of outer nuclear layer (ONL) thickness. NaIO3 also was studied by using in vitro assays. Results: In SW-AF and NIR-AF images, fundus mottling was visible 3 and 7 days after NaIO3 injection with changes being more pronounced in Abca4-/- mice that are characterized by an abundance of RPE bisretinoid lipofuscin. In Abca4-/- mice, qAF was elevated 3 and 7 days after NaIO3 administration. In light micrographs and RPE flat-mounts stained to reveal tight junctions (ZO-1) and nuclei, the RPE monolayer was disorganized, and clumping and loss of RPE was visible. ONL thinning was most pronounced in Abca4-/- mice. Treatment of ARPE-19 cells with NaIO3 together with the photooxidation of the bisretinoid A2E by exposure to 430-nm light produced an additive effect whereby loss of cell viability was greater than with either perturbation alone. Conclusions: Elevations in SW-AF intensity can occur due to photoreceptor cell dysfunction as induced secondarily by NaIO3. Photooxidative stress associated with RPE cell bisretinoid lipofuscin may confer increased susceptibility to the oxidant NaIO3.
[Mh] Termos MeSH primário: Angiofluoresceinografia/métodos
Iodatos/farmacologia
Degeneração Macular/diagnóstico
Imagem Multimodal/métodos
Epitélio Pigmentado da Retina/patologia
[Mh] Termos MeSH secundário: Animais
Cromatografia Líquida de Alta Pressão
Modelos Animais de Doenças
Seguimentos
Fundo de Olho
Camundongos
Fotomicrografia
Epitélio Pigmentado da Retina/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Iodates); U558PCS5Z9 (sodium iodate)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170411
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-21557


  6 / 3410 MEDLINE  
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[PMID]:28376733
[Au] Autor:Said AM; Zaki RG; Salah Eldin RA; Nasr M; Azab SS; Elzankalony YA
[Ad] Endereço:Ophthalmology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Dr_azza_22@hotmail.com.
[Ti] Título:Efficacy of Intravitreal injection of 2-Methoxyestradiol in regression of neovascularization of a retinopathy of prematurity rat model.
[So] Source:BMC Ophthalmol;17(1):38, 2017 Apr 04.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Retinopathy of prematurity (ROP) is one of the targets for early detection and treatment to prevent childhood blindness in world health organization programs. The purpose of study was to evaluate the efficacy of intravitreal injection of 2-Methoxyestradiol (2-ME) nanoemulsion in regressing neovascularization of a ROP rat model. METHODS: A prospective comparative case - control animal study conducted on 56 eyes of 28 healthy new born Sprague Dawley male albino rat. ROP was induced in 21 rats then two concentrations of 2-ME nanoparticles were injected in right eyes of 14 rats (low dose; study group I, high dose; study group II). A blank nanoemulsion was injected in the right eyes of seven rats (control positive group I). No injections performed in contralateral left eyes (control positive group II). Seven rats (14 eyes) were kept in room air (control negative group). On postnatal day 17, eyeballs were enucleated. Histological structure of the retina was examined using Hematoxylin and eosin staining. Vascular endothelial growth factor (VEGF) and glial fibrillary acidic protein (GFAP) expressions were detected by immunohistochemical studies. RESULTS: Intravitreal injection of 2-ME (in the two concentrations) caused marked regression of the new vascular tufts on the vitreal side with normal organization and thickness of the retina especially in study group II, which also show negative VEGF immunoreaction. Positive GFAP expression was detected in the control positive groups and study group (I). CONCLUSION: Intravitreal injection of 2-Methoxyestradiol nanoemulsion is a promising effective method in reduction of neovascularization of a ROP rat model.
[Mh] Termos MeSH primário: Estradiol/análogos & derivados
Neovascularização Retiniana/tratamento farmacológico
Vasos Retinianos/patologia
Retinopatia da Prematuridade/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Modelos Animais de Doenças
Progressão da Doença
Estradiol/administração & dosagem
Imuno-Histoquímica
Injeções Intravítreas
Masculino
Fotomicrografia
Estudos Prospectivos
Ratos
Ratos Sprague-Dawley
Neovascularização Retiniana/diagnóstico
Neovascularização Retiniana/etiologia
Retinopatia da Prematuridade/complicações
Retinopatia da Prematuridade/patologia
Moduladores de Tubulina/administração & dosagem
Fator A de Crescimento do Endotélio Vascular/antagonistas & inibidores
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Tubulin Modulators); 0 (Vascular Endothelial Growth Factor A); 4TI98Z838E (Estradiol); 6I2QW73SR5 (2-methoxyestradiol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-017-0433-3


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[PMID]:28332866
[Au] Autor:Song D; Zhang L; Zhou W; Zheng Q; Duan X; Zhou X; Huang D
[Ad] Endereço:1 State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
[Ti] Título:Comparing cone-beam computed tomography with periapical radiography for assessing root canal obturation in vivo using microsurgical findings as validation.
[So] Source:Dentomaxillofac Radiol;46(5):20160463, 2017 Jul.
[Is] ISSN:0250-832X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The aim of this study was to verify whether there is a difference in the in vivo performance characteristics of CBCT and periapical radiography (PR) in assessing the apical extension of root canal obturation (RCO) and to evaluate the ability of CBCT in void detection using microsurgical findings as validation. METHODS: This study included 323 tooth roots that required surgical treatment and for which pre-existing periapical radiographs and CBCT images were available. Three calibrated observers individually analyzed the periapical radiographs, CBCT images and photomicrographs of each root. Performance characteristics of CBCT and PR were compared in terms of their evaluation of the apical extension of the RCOs. The ability of CBCT to detect voids in the RCOs was evaluated using microsurgical findings as validation. Kappa values were used for intraobserver/interobserver agreement. RESULTS: Perfect intraobserver/interobserver agreement (1.0) was achieved when using photomicrography. The two agreements of PR were superior to those of CBCT when CBCT was used to detect voids (p < 0.05). The sensitivity of CBCT [0.86, 95% confidence interval (CI) 0.76-0.93] was superior to that of PR (0.66, 95% CI 0.54-0.76) in detecting overextension (p < 0.005). CBCT showed a poor sensitivity (0.24, 95% CI 0.19-0.30) and specificity (0.67, 95% CI 0.54-0.78) in void detection. CONCLUSIONS: CBCT was better than PR for evaluating the apical extension of RCOs. CBCT, with its poor sensitivity and specificity, might both overestimate and underestimate the proportion of voids in RCOs. CBCT was not suitable for evaluating the quality of RCOs.
[Mh] Termos MeSH primário: Tomografia Computadorizada de Feixe Cônico/métodos
Radiografia Dentária Digital/métodos
Obturação do Canal Radicular
Raiz Dentária/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Microcirurgia
Fotomicrografia
Reprodutibilidade dos Testes
Raiz Dentária/cirurgia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE
[do] DOI:10.1259/dmfr.20160463


  8 / 3410 MEDLINE  
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[PMID]:28178946
[Au] Autor:Yang J; Litscher G; Sun Z; Tang Q; Kishi K; Oda S; Takayanagi M; Sheng Z; Liu Y; Guo W; Zhang T; Wang L; Gaischek I; Litscher D; Lippe IT; Kuroda M
[Ad] Endereço:Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, 150001, China. junli201601@126.com.
[Ti] Título:Quantitative analysis of axon collaterals of single pyramidal cells of the anterior piriform cortex of the guinea pig.
[So] Source:BMC Neurosci;18(1):25, 2017 Feb 08.
[Is] ISSN:1471-2202
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The role of the piriform cortex (PC) in olfactory information processing remains largely unknown. The anterior part of the piriform cortex (APC) has been the focus of cortical-level studies of olfactory coding, and associative processes have attracted considerable attention as an important part in odor discrimination and olfactory information processing. Associational connections of pyramidal cells in the guinea pig APC were studied by direct visualization of axons stained and quantitatively analyzed by intracellular biocytin injection in vivo. RESULTS: The observations illustrated that axon collaterals of the individual cells were widely and spatially distributed within the PC, and sometimes also showed a long associational projection to the olfactory bulb (OB). The data showed that long associational axons were both rostrally and caudally directed throughout the PC, and the intrinsic associational fibers of pyramidal cells in the APC are omnidirectional connections in the PC. Within the PC, associational axons typically followed rather linear trajectories and irregular bouton distributions. Quantitative data of the axon collaterals of two pyramidal cells in the APC showed that the average length of axonal collaterals was 101 mm, out of which 79 mm (78% of total length) were distributed in the PC. The average number of boutons was 8926 and 7101, respectively, with 79% of the total number of boutons being distributed in the PC. The percentage of the total area of the APC and the posterior piriform cortex occupied by the average distribution region of the axon collaterals of two superficial pyramidal (SP) cells was about 18 and 5%, respectively. CONCLUSION: Our results demonstrate that omnidirectional connection of pyramidal cells in the APC provides a substrate for recurrent processes. These findings indicate that the axon collaterals of SP cells in the PC could make synaptic contacts with all granule cells in the OB. This study provides the morphological evidence for understanding the mechanisms of information processing and associative memory in the APC.
[Mh] Termos MeSH primário: Axônios
Córtex Piriforme/citologia
Células Piramidais/citologia
[Mh] Termos MeSH secundário: Animais
Tamanho Celular
Feminino
Cobaias
Lisina/análogos & derivados
Masculino
Bulbo Olfatório/citologia
Condutos Olfatórios/citologia
Fotomicrografia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
G6D6147J22 (biocytin); K3Z4F929H6 (Lysine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170210
[St] Status:MEDLINE
[do] DOI:10.1186/s12868-017-0342-7


  9 / 3410 MEDLINE  
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[PMID]:28127801
[Au] Autor:Aguilar C; Soca R; Guillen M; Paucca E; Illatopa V
[Ad] Endereço:Laboratory of Pathology, Instituto Nacional Cardiovascular, Lima, Peru.
[Ti] Título:Cardiac undifferentiated pleomorphic sarcoma incidentally diagnosed during mitral valve replacement.
[So] Source:J Card Surg;32(2):91-92, 2017 Feb.
[Is] ISSN:1540-8191
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Procedimentos Cirúrgicos Cardíacos/métodos
Neoplasias Cardíacas/diagnóstico
Achados Incidentais
Insuficiência da Valva Mitral/cirurgia
Estenose da Valva Mitral/cirurgia
Sarcoma/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Ecocardiografia
Evolução Fatal
Feminino
Átrios do Coração
Neoplasias Cardíacas/complicações
Neoplasias Cardíacas/cirurgia
Seres Humanos
Imagem Tridimensional
Período Intraoperatório
Imagem Cinética por Ressonância Magnética
Insuficiência da Valva Mitral/complicações
Insuficiência da Valva Mitral/diagnóstico
Estenose da Valva Mitral/complicações
Estenose da Valva Mitral/diagnóstico
Fotomicrografia
Tomografia por Emissão de Pósitrons
Sarcoma/complicações
Sarcoma/cirurgia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170517
[Lr] Data última revisão:
170517
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170128
[St] Status:MEDLINE
[do] DOI:10.1111/jocs.13087


  10 / 3410 MEDLINE  
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[PMID]:28056040
[Au] Autor:Moraes MM; Galvão MC; Cabral D; Coelho CP; Queiroz-Hazarbassanov N; Martins MF; Bondan EF; Bernardi MM; Kirsten TB
[Ad] Endereço:Environmental and Experimental Pathology, Paulista University, Sao Paulo, Brazil.
[Ti] Título:Propentofylline Prevents Sickness Behavior and Depressive-Like Behavior Induced by Lipopolysaccharide in Rats via Neuroinflammatory Pathway.
[So] Source:PLoS One;12(1):e0169446, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recent studies have demonstrated the intimate relationship between depression and immune disturbances. Aware of the efficacy limits of existing antidepressant drugs and the potential anti-inflammatory properties of propentofylline, we sought to evaluate the use of propentofylline as a depression treatment. We used a rat model of depression induced by repetitive lipopolysaccharide (LPS) administrations. We have studied sickness behavior, by assessing daily body weight, open field behavior, and TNF-α plasmatic levels. Anxiety-like behavior (light-dark test), depressive-like behavior (forced swim test), plasmatic levels of the brain-derived neurotrophic factor (BDNF, depression biomarker), and central glial fibrillary acidic protein (GFAP) expression (an astrocyte biomarker) were also evaluated. LPS induced body weight loss, open field behavior impairments (decreased locomotion and rearing, and increased immobility), and increased TNF-α levels in rats, compared with control group. Thus, LPS induced sickness behavior. LPS also increased the immobility and reduced climbing in the forced swim test, when compared with the control group, i.e., LPS induced depressive-like behavior in rats. Propentofylline prevented sickness behavior after four days of consecutive treatment, as well as prevented the depressive-like behavior after five days of consecutive treatments. Propentofylline also prevented the increase in GFAP expression induced by LPS. Neither LPS nor propentofylline has influenced the anxiety and BDNF levels of rats. In conclusion, repetitive LPS administrations induced sickness behavior and depressive-like behavior in rats. Propentofylline prevented both sickness behavior and depressive-like behavior via neuroinflammatory pathway. The present findings may contribute to a better understanding and treatment of depression and associated diseases.
[Mh] Termos MeSH primário: Depressão/tratamento farmacológico
Lipopolissacarídeos/toxicidade
Xantinas/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Antidepressivos
Ansiedade/tratamento farmacológico
Comportamento Animal/efeitos dos fármacos
Peso Corporal/efeitos dos fármacos
Fator Neurotrófico Derivado do Encéfalo/metabolismo
Transtorno Depressivo/tratamento farmacológico
Modelos Animais de Doenças
Proteína Glial Fibrilar Ácida/metabolismo
Comportamento de Doença/efeitos dos fármacos
Imuno-Histoquímica
Masculino
Fotomicrografia
Ratos
Ratos Wistar
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidepressive Agents); 0 (Brain-Derived Neurotrophic Factor); 0 (Glial Fibrillary Acidic Protein); 0 (Lipopolysaccharides); 0 (Tumor Necrosis Factor-alpha); 0 (Xanthines); 0 (glial fibrillary acid protein, rat); 5RTA398U4H (propentofylline)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0169446



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