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[PMID]:29329355
[Au] Autor:Beaton LE; Azma S; Marinkovic K
[Ad] Endereço:Department of Psychology, San Diego State University, San Diego, California, United States of America.
[Ti] Título:When the brain changes its mind: Oscillatory dynamics of conflict processing and response switching in a flanker task during alcohol challenge.
[So] Source:PLoS One;13(1):e0191200, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite the subjective experience of being in full and deliberate control of our actions, our daily routines rely on a continuous and interactive engagement of sensory evaluation and response preparation streams. They unfold automatically and unconsciously and are seamlessly integrated with cognitive control which is mobilized by stimuli that evoke ambiguity or response conflict. Methods with high spatio-temporal sensitivity are needed to provide insight into the interplay between automatic and controlled processing. This study used anatomically-constrained MEG to examine the underlying neural dynamics in a flanker task that manipulated S-R incongruity at the stimulus (SI) and response levels (RI). Though irrelevant, flankers evoked automatic preparation of motor plans which had to be suppressed and reversed following the target presentation on RI trials. Event-related source power estimates in beta (15-25 Hz) frequency band in the sensorimotor cortex tracked motor preparation and response in real time and revealed switching from the incorrectly-primed to the correctly-responding hemisphere. In contrast, theta oscillations (4-7 Hz) were sensitive to the levels of incongruity as the medial and ventrolateral frontal cortices were especially activated by response conflict. These two areas are key to cognitive control and their integrated contributions to response inhibition and switching were revealed by phase-locked co-oscillations. These processes were pharmacologically manipulated with a moderate alcohol beverage or a placebo administered to healthy social drinkers. Alcohol selectively decreased accuracy to response conflict. It strongly attenuated theta oscillations during decision making and partly re-sculpted relative contributions of the frontal network without affecting the motor switching process subserved by beta band. Our results indicate that motor preparation is initiated automatically even when counterproductive but that it is monitored and regulated by the prefrontal cognitive control processes under conflict. They further confirm that the regulative top-down functions are particularly vulnerable to alcohol intoxication.
[Mh] Termos MeSH primário: Consumo de Bebidas Alcoólicas/fisiopatologia
Consumo de Bebidas Alcoólicas/psicologia
Encéfalo/fisiologia
Conflito (Psicologia)
[Mh] Termos MeSH secundário: Adulto
Intoxicação Alcoólica/fisiopatologia
Intoxicação Alcoólica/psicologia
Ritmo beta/efeitos dos fármacos
Ritmo beta/fisiologia
Encéfalo/diagnóstico por imagem
Encéfalo/efeitos dos fármacos
Mapeamento Encefálico
Cognição/efeitos dos fármacos
Cognição/fisiologia
Etanol/efeitos adversos
Feminino
Neuroimagem Funcional
Seres Humanos
Imagem por Ressonância Magnética
Magnetoencefalografia
Masculino
Córtex Pré-Frontal/diagnóstico por imagem
Córtex Pré-Frontal/efeitos dos fármacos
Córtex Pré-Frontal/fisiologia
Desempenho Psicomotor/efeitos dos fármacos
Desempenho Psicomotor/fisiologia
Ritmo Teta/efeitos dos fármacos
Ritmo Teta/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
3K9958V90M (Ethanol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191200


  2 / 2402 MEDLINE  
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[PMID]:29061386
[Au] Autor:Klumpp H; Bhaumik R; Kinney KL; Fitzgerald JM
[Ad] Endereço:Department of Psychiatry (HK, RB), University of Illinois at Chicago, Chicago, IL, United States; Department of Psychology (HK, KLK), University of Illinois at Chicago, Chicago, IL, United States. Electronic address: hklumpp@psych.uic.edu.
[Ti] Título:Principal component analysis and neural predictors of emotion regulation.
[So] Source:Behav Brain Res;338:128-133, 2018 Feb 15.
[Is] ISSN:1872-7549
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Reappraisal, a cognitive approach intended to alter an emotional response, is generally associated with prefrontal cortical recruitment and decreased limbic activity. However, the extent to which neurofunctional activity predicts successful reappraisal is unclear. During fMRI, 60 healthy participants completed a reappraisal paradigm, which included reappraising negative images to reduce emotional reactivity ('ReappNeg') and viewing negative images and experiencing the negative affect they evoke ('LookNeg'). After each trial, participants rated their emotional response on a Likert-type scale where higher values indicated more negative affect. Reappraisal ability was based on a difference value (ΔReappNeg-LookNeg) such that negative values signified successful reappraisal ('SR'; n=38) and positive values, unsuccessful reappraisal ('USR'; n=22). Neural activity based on ReappNeg-LookNeg conditions from 37 regions of interest encompassing cortical and limbic areas was submitted to Principal Component Analysis (PCA). Resulting PCA factors were submitted to discriminant function analysis to evaluate which factor(s) predicted SR and USR groups. Results showed a factor with high loadings for certain frontal areas (e.g., left dorsomedial prefrontal cortex) and limbic regions (e.g., bilateral amygdala) predicted 71.1% of cases in the SR group and 68.2% of cases in the USR group. Additionally, successful reappraisal corresponded with more activation in the factor with high loadings for frontal areas and less activity in the factor associated with limbic regions. Results are consistent with studies of individual differences where more prefrontal engagement and less limbic activity is associated with effectual reappraisal, but for the first time, a neural 'signature' for successful reappraisal has been demonstrated.
[Mh] Termos MeSH primário: Encéfalo/diagnóstico por imagem
Cognição/fisiologia
Emoções/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Afeto/fisiologia
Encéfalo/fisiologia
Mapeamento Encefálico
Feminino
Neuroimagem Funcional
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Análise de Componente Principal
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180218
[Lr] Data última revisão:
180218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171025
[St] Status:MEDLINE


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[PMID]:29320526
[Au] Autor:Chiang S; Vankov ER; Yeh HJ; Guindani M; Vannucci M; Haneef Z; Stern JM
[Ad] Endereço:Department of Statistics, Rice University, Houston, Texas, United States of America.
[Ti] Título:Temporal and spectral characteristics of dynamic functional connectivity between resting-state networks reveal information beyond static connectivity.
[So] Source:PLoS One;13(1):e0190220, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Estimation of functional connectivity (FC) has become an increasingly powerful tool for investigating healthy and abnormal brain function. Static connectivity, in particular, has played a large part in guiding conclusions from the majority of resting-state functional MRI studies. However, accumulating evidence points to the presence of temporal fluctuations in FC, leading to increasing interest in estimating FC as a dynamic quantity. One central issue that has arisen in this new view of connectivity is the dramatic increase in complexity caused by dynamic functional connectivity (dFC) estimation. To computationally handle this increased complexity, a limited set of dFC properties, primarily the mean and variance, have generally been considered. Additionally, it remains unclear how to integrate the increased information from dFC into pattern recognition techniques for subject-level prediction. In this study, we propose an approach to address these two issues based on a large number of previously unexplored temporal and spectral features of dynamic functional connectivity. A Generalized Autoregressive Conditional Heteroskedasticity (GARCH) model is used to estimate time-varying patterns of functional connectivity between resting-state networks. Time-frequency analysis is then performed on dFC estimates, and a large number of previously unexplored temporal and spectral features drawn from signal processing literature are extracted for dFC estimates. We apply the investigated features to two neurologic populations of interest, healthy controls and patients with temporal lobe epilepsy, and show that the proposed approach leads to substantial increases in predictive performance compared to both traditional estimates of static connectivity as well as current approaches to dFC. Variable importance is assessed and shows that there are several quantities that can be extracted from dFC signal which are more informative than the traditional mean or variance of dFC. This work illuminates many previously unexplored facets of the dynamic properties of functional connectivity between resting-state networks, and provides a platform for dynamic functional connectivity analysis that facilitates its usage as an investigative measure for healthy as well as abnormal brain function.
[Mh] Termos MeSH primário: Conectoma
Neuroimagem Funcional
Rede Nervosa/fisiologia
[Mh] Termos MeSH secundário: Adulto
Análise de Variância
Córtex Cerebral/fisiologia
Epilepsia do Lobo Temporal/fisiopatologia
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Modelos Neurológicos
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190220


  4 / 2402 MEDLINE  
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[PMID]:28742093
[Au] Autor:Hermes D; Nguyen M; Winawer J
[Ad] Endereço:Department of Psychology, New York University, New York, New York, United States of America.
[Ti] Título:Neuronal synchrony and the relation between the blood-oxygen-level dependent response and the local field potential.
[So] Source:PLoS Biol;15(7):e2001461, 2017 Jul.
[Is] ISSN:1545-7885
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The most widespread measures of human brain activity are the blood-oxygen-level dependent (BOLD) signal and surface field potential. Prior studies report a variety of relationships between these signals. To develop an understanding of how to interpret these signals and the relationship between them, we developed a model of (a) neuronal population responses and (b) transformations from neuronal responses into the functional magnetic resonance imaging (fMRI) BOLD signal and electrocorticographic (ECoG) field potential. Rather than seeking a transformation between the two measures directly, this approach interprets each measure with respect to the underlying neuronal population responses. This model accounts for the relationship between BOLD and ECoG data from human visual cortex in V1, V2, and V3, with the model predictions and data matching in three ways: across stimuli, the BOLD amplitude and ECoG broadband power were positively correlated, the BOLD amplitude and alpha power (8-13 Hz) were negatively correlated, and the BOLD amplitude and narrowband gamma power (30-80 Hz) were uncorrelated. The two measures provide complementary information about human brain activity, and we infer that features of the field potential that are uncorrelated with BOLD arise largely from changes in synchrony, rather than level, of neuronal activity.
[Mh] Termos MeSH primário: Sincronização Cortical
Hipóxia Encefálica/etiologia
Modelos Neurológicos
Potenciais Sinápticos
Córtex Visual/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Algoritmos
Monitorização Transcutânea dos Gases Sanguíneos
Simulação por Computador
Eletrocorticografia
Feminino
Neuroimagem Funcional
Seres Humanos
Hipóxia Encefálica/sangue
Imagem por Ressonância Magnética
Masculino
Neurônios/metabolismo
Oxigênio/sangue
Análise de Componente Principal
Reprodutibilidade dos Testes
Córtex Visual/irrigação sanguínea
Córtex Visual/metabolismo
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
S88TT14065 (Oxygen)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pbio.2001461


  5 / 2402 MEDLINE  
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[PMID]:29079512
[Au] Autor:Ladouceur CD; Schlund MW; Segreti AM
[Ad] Endereço:Department of Psychiatry, School of Medicine, University of Pittsburgh, 3811 O'Hara St., Pittsburgh, PA 15213, United States. Electronic address: ladouceurcd@upmc.edu.
[Ti] Título:Positive reinforcement modulates fronto-limbic systems subserving emotional interference in adolescents.
[So] Source:Behav Brain Res;338:109-117, 2018 Feb 15.
[Is] ISSN:1872-7549
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Fronto-limbic systems play an important role in supporting resistance to emotional distraction to promote goal-directed behavior. Despite evidence that alterations in the functioning of these systems are implicated in developmental trajectories of psychopathology, most studies have been conducted in adults. This study examined the functioning of fronto-limbic systems subserving emotional interference in adolescents and whether differential reinforcement of correct responding can modulate these neural systems in ways that could promote resistance to emotional distraction. Fourteen healthy adolescents (ages 9-15) completed an emotional delayed working memory task during fMRI with emotional distracters (none, neutral, negative) while positive reinforcement (i.e., monetary reward) was provided for correct responses under some conditions. Adolescents showed slightly reduced behavioral performance and greater activation in amygdala and prefrontal cortical regions (ventrolateral, ventromedial, dorsolateral) on correct trials with negative distracters compared to those with no or neutral distracters. Positive reinforcement yielded an overall improvement in accuracy and reaction times and counteracted the effects of negative distracters as evidenced by significant reductions in activation in key fronto-limbic regions. The present findings extend results on emotional interference from adults to adolescents and suggest that positive reinforcement could be used to potentially promote insulation from emotional distraction. A challenge for the future will be to build upon these findings for constructing reinforcement-based attention training programs that could be used to reduce emotional attention biases in anxious youth.
[Mh] Termos MeSH primário: Emoções/fisiologia
Lobo Frontal/fisiologia
Reforço (Psicologia)
[Mh] Termos MeSH secundário: Adolescente
Atenção/fisiologia
Criança
Feminino
Lobo Frontal/diagnóstico por imagem
Neuroimagem Funcional
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Memória de Curto Prazo/fisiologia
Testes Neuropsicológicos
Tempo de Reação/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171029
[St] Status:MEDLINE


  6 / 2402 MEDLINE  
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[PMID]:28462585
[Au] Autor:Ye Z; Hammer A; Münte TF
[Ad] Endereço:1 Department of Neurology, University of Lübeck , Lübeck, Germany .
[Ti] Título:Pramipexole Modulates Interregional Connectivity Within the Sensorimotor Network.
[So] Source:Brain Connect;7(4):258-263, 2017 May.
[Is] ISSN:2158-0022
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pramipexole is widely prescribed to treat Parkinson's disease but has been reported to cause impulse control disorders such as pathological gambling. Recent neurocomputational models suggested that D2 agonists may distort functional connections between the striatum and the motor cortex, resulting in impaired reinforcement learning and pathological gambling. To examine how D2 agonists modulate the striatal-motor connectivity, we carried out a pharmacological resting-state functional magnetic resonance imaging study with a double-blind randomized within-subject crossover design. We analyzed the medication-induced changes of network connectivity and topology with two approaches, an independent component analysis (ICA) and a graph theoretical analysis (GTA). The ICA identified the sensorimotor network (SMN) as well as other classical resting-state networks. Within the SMN, the connectivity between the right caudate nucleus and other cortical regions was weaker under pramipexole than under placebo. The GTA measured the topological properties of the whole-brain network at global and regional levels. Both the whole-brain network under placebo and that under pramipexole were identified as small-world networks. The two whole-brain networks were similar in global efficiency, clustering coefficient, small-world index, and modularity. However, the degree of the right caudate nucleus decreased under pramipexole mainly due to the loss of the connectivity with the supplementary motor area, paracentral lobule, and precentral and postcentral gyrus of the SMN. The two network analyses consistently revealed that pramipexole weakened the functional connectivity between the caudate nucleus and the SMN regions.
[Mh] Termos MeSH primário: Benzotiazóis/farmacologia
Agonistas de Dopamina/farmacologia
Neostriado/efeitos dos fármacos
Córtex Sensório-Motor/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adulto
Encéfalo/diagnóstico por imagem
Encéfalo/efeitos dos fármacos
Encéfalo/fisiologia
Estudos Cross-Over
Método Duplo-Cego
Neuroimagem Funcional
Voluntários Saudáveis
Seres Humanos
Masculino
Córtex Motor/diagnóstico por imagem
Córtex Motor/efeitos dos fármacos
Córtex Motor/fisiologia
Neostriado/diagnóstico por imagem
Neostriado/fisiologia
Vias Neurais/diagnóstico por imagem
Vias Neurais/efeitos dos fármacos
Vias Neurais/fisiologia
Córtex Sensório-Motor/diagnóstico por imagem
Córtex Sensório-Motor/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Benzothiazoles); 0 (Dopamine Agonists); 83619PEU5T (pramipexole)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1089/brain.2017.0484


  7 / 2402 MEDLINE  
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[PMID]:28454522
[Au] Autor:Becker A; Ehret AM; Kirsch P
[Ad] Endereço:Department of Clinical Psychology, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany. alena.becker@zi-mannheim.de.
[Ti] Título:From the neurobiological basis of comorbid alcohol dependence and depression to psychological treatment strategies: study protocol of a randomized controlled trial.
[So] Source:BMC Psychiatry;17(1):153, 2017 04 28.
[Is] ISSN:1471-244X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Alcohol use disorder and depression occur commonly in the community. Even though this high-prevalence comorbidity is associated with poorer posttreatment outcomes and greater utilization of costly treatment services, existing treatment trials often exclude patients with comorbid depressive and alcohol use disorders. Past research suggests that symptoms such as craving and anhedonia might be associated with alterations within the reward circuit, while emotion regulation deficits are related to disruptions within the default mode network. The aim of this clinical neuroimaging study is to transfer previous research about the reward circuit and default mode network underlying alcohol use disorder and depression to achieve a better understanding of neural signatures characterizing their comorbidity. In addition, the neurobiological results will be used to test whether two psychotherapeutic intervention programs, mindfulness-based training and behavioral activation training, are able to positively influence the identified pathomechanisms. METHODS: By means of functional magnetic resonance imaging (fMRI), 60 comorbid alcohol dependent and depressed patients are compared to 30 patients with depression only, 30 patients with alcohol use disorder only and 30 healthy control participants. Comorbid patients are randomized to either receive a behavioral activation or mindfulness based training and asked to participate in a second fMRI session and 3 month follow-up assessment. Thereby, we plan to explore whether these brief group psychotherapeutic intervention programs are able to positively influence the identified neurobiological pathomechanisms. The primary outcomes are reward and default mode network activity and connectivity evoked by paradigms measuring different facets of reward and emotion processing. Secondary outcome measures include craving and depression scores, as well as relapse rates. Predictors include participants' characteristics, personality traits and indicators of mental health. DISCUSSION: The objective of the project is to identify common and/or distinct neural signatures underlying the comorbidity of alcohol dependence and depression. If the neurobiological understanding of alcohol addiction and depression is improved, this could potentially serve as a key predictor of treatment response to specific types of behavioral or mindfulness therapies hypothesized to alter reward and resting state systems. TRIAL REGISTRATION: German Clinical Trial Register DRKS00010249 . The trial was registered January 23th 2017.
[Mh] Termos MeSH primário: Alcoolismo/epidemiologia
Alcoolismo/fisiopatologia
Protocolos Clínicos
Depressão/epidemiologia
Depressão/fisiopatologia
Vias Neurais/fisiopatologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Alcoolismo/terapia
Terapia Comportamental/métodos
Comorbidade
Depressão/terapia
Feminino
Neuroimagem Funcional
Alemanha/epidemiologia
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Índice de Gravidade de Doença
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1186/s12888-017-1324-0


  8 / 2402 MEDLINE  
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[PMID]:28470485
[Au] Autor:Sudol K; Mann JJ
[Ad] Endereço:Frank H. Netter MD School of Medicine, Quinnipiac University, 370 Bassett Road, North Haven, CT, 06473, USA.
[Ti] Título:Biomarkers of Suicide Attempt Behavior: Towards a Biological Model of Risk.
[So] Source:Curr Psychiatry Rep;19(6):31, 2017 Jun.
[Is] ISSN:1535-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: The rising suicide rate in the USA will not be reversed without improved risk assessment and prevention practices. To date, the best method for clinicians to assess a patient's risk for suicide is screening for past suicide attempts in the patient and their family. However, neuroimaging, genomic, and biochemical studies have generated a body of findings that allow description of an initial heuristic biological model for suicidal behavior that may have predictive value. RECENT FINDINGS: We review studies from the past 3 years examining potential biological predictors of suicide attempt behavior. We divide findings into two major categories: (1) structural and functional brain imaging findings and (2) biochemical and genomic findings encompassing several systems, including major neurotransmitters (serotonin, catecholamines, GABA, and glutamate), the hypothalamic pituitary adrenal (HPA) axis, the inflammasome, lipids, and neuroplasticity. The biomarkers that appear promising for assessing suicide risk in clinical settings include indices of serotonergic function, inflammation, neuronal plasticity, and lipids.
[Mh] Termos MeSH primário: Sintomas Comportamentais
Neuroimagem Funcional/métodos
Neurotransmissores/metabolismo
Medição de Risco/métodos
Tentativa de Suicídio
[Mh] Termos MeSH secundário: Sintomas Comportamentais/genética
Sintomas Comportamentais/metabolismo
Sintomas Comportamentais/fisiopatologia
Biomarcadores/metabolismo
Predisposição Genética para Doença
Seres Humanos
Sistema Hipotálamo-Hipofisário/fisiologia
Modelos Biológicos
Plasticidade Neuronal/fisiologia
Sistema Hipófise-Suprarrenal/fisiologia
Tentativa de Suicídio/prevenção & controle
Tentativa de Suicídio/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); 0 (Neurotransmitter Agents)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1007/s11920-017-0781-y


  9 / 2402 MEDLINE  
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[PMID]:29173308
[Au] Autor:Hutton JS; Phelan K; Horowitz-Kraus T; Dudley J; Altaye M; DeWitt T; Holland SK
[Ad] Endereço:Division of General and Community Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Reading and Literacy Discovery Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. Electronic address: John1.Hutton@cchmc.org.
[Ti] Título:Shared Reading Quality and Brain Activation during Story Listening in Preschool-Age Children.
[So] Source:J Pediatr;191:204-211.e1, 2017 Dec.
[Is] ISSN:1097-6833
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To explore the relationship between maternal shared reading quality (verbal interactivity and engagement) and brain function during story listening in at-risk, preschool-age children, in the context of behavioral evidence and American Academy of Pediatrics, recommendations. STUDY DESIGN: In this cross-sectional study, 22 healthy, 4-year-old girls from low socioeconomic status households completed functional magnetic resonance imaging using an established story listening task, followed by videotaped observation of uncoached mother-daughter reading of the same, age-appropriate picture book. Shared reading quality was independently scored applying dialogic reading and other evidence-based criteria reflecting interactivity and engagement, and applied as a predictor of neural activation during the functional magnetic resonance imaging task, controlling for income and maternal education. RESULTS: Shared reading quality scores were generally low and negatively correlated with maternal distraction by smartphones (P < .05). Scores were positively correlated with activation in left-sided brain areas supporting expressive and complex language, social-emotional integration, and working memory (P <.05, false discovery rate corrected). CONCLUSIONS: Maternal shared reading quality is positively correlated with brain activation supporting complex language, executive function, and social-emotional processing in at-risk, preschool-age children. These findings represent novel neural biomarkers of how this modifiable aspect of home reading environment may influence foundational emergent literacy skills, reinforce behavioral evidence and American Academy of Pediatrics, recommendations, and underscore the potential of dialogic reading interventions to promote healthy brain development, especially in at-risk households.
[Mh] Termos MeSH primário: Encéfalo/fisiologia
Neuroimagem Funcional
Imagem por Ressonância Magnética
Comportamento Materno
Relações Mãe-Filho/psicologia
Leitura
Comportamento Verbal/fisiologia
[Mh] Termos MeSH secundário: Adulto
Pré-Escolar
Estudos Transversais
Feminino
Seres Humanos
Modelos Lineares
Alfabetização
Classe Social
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:27776563
[Au] Autor:Rikandi E; Pamilo S; Mäntylä T; Suvisaari J; Kieseppä T; Hari R; Seppä M; Raij TT
[Ad] Endereço:Mental Health Unit,National Institute for Health and Welfare,Helsinki,Finland.
[Ti] Título:Precuneus functioning differentiates first-episode psychosis patients during the fantasy movie Alice in Wonderland.
[So] Source:Psychol Med;47(3):495-506, 2017 Feb.
[Is] ISSN:1469-8978
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: While group-level functional alterations have been identified in many brain regions of psychotic patients, multivariate machine-learning methods provide a tool to test whether some of such alterations could be used to differentiate an individual patient. Earlier machine-learning studies have focused on data collected from chronic patients during rest or simple tasks. We set out to unravel brain activation patterns during naturalistic stimulation in first-episode psychosis (FEP). METHOD: We recorded brain activity from 46 FEP patients and 32 control subjects viewing scenes from the fantasy film Alice in Wonderland. Scenes with varying degrees of fantasy were selected based on the distortion of the 'sense of reality' in psychosis. After cleaning the data with a novel maxCorr method, we used machine learning to classify patients and healthy control subjects on the basis of voxel- and time-point patterns. RESULTS: Most (136/194) of the voxels that best classified the groups were clustered in a bilateral region of the precuneus. Classification accuracies were up to 79.5% (p = 5.69 × 10-8), and correct classification was more likely the higher the patient's positive-symptom score. Precuneus functioning was related to the fantasy content of the movie, and the relationship was stronger in control subjects than patients. CONCLUSIONS: These findings are the first to show abnormalities in precuneus functioning during naturalistic information processing in FEP patients. Correlational findings suggest that these alterations are associated with positive psychotic symptoms and processing of fantasy. The results may provide new insights into the neuronal basis of reality distortion in psychosis.
[Mh] Termos MeSH primário: Fantasia
Neuroimagem Funcional/métodos
Aprendizado de Máquina
Lobo Parietal/fisiopatologia
Transtornos Psicóticos/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Filmes Cinematográficos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1017/S0033291716002609



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