Base de dados : MEDLINE
Pesquisa : E01.370.350.578.937.260.850 [Categoria DeCS]
Referências encontradas : 6700 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 670 ir para página                         

  1 / 6700 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28455103
[Au] Autor:Williams CAL; Panerai RB; Robinson TG; Haunton VJ
[Ad] Endereço:University of Leicester, Department of Cardiovascular Sciences, Leicester, UK. Electronic address: calw1@student.le.ac.uk.
[Ti] Título:Transcranial Doppler ultrasonography in the assessment of neurovascular coupling responses to cognitive examination in healthy controls: A feasibility study.
[So] Source:J Neurosci Methods;284:57-62, 2017 Jun 01.
[Is] ISSN:1872-678X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We tested the hypothesis that paradigms from the Addenbrooke's Cognitive Examination (ACE-III), including those that had not been studied using TCD previously (novel) versus those which had been (established), would elicit changes in CBF velocity (CBFv). NEW METHOD: Healthy subjects were studied with bilateral transcranial Doppler (TCD), beat-to-beat blood pressure (Finapres), continuous electrocardiogram (ECG), and end-tidal CO (nasal capnography). After a 5-min baseline recording, cognitive tests of the ACE-III were presented to subjects, covering attention (SUB7, subtracting 7 from 100 sequentially), language (REP, repeating words and phrases), fluency (N-P, naming words), visuospatial (DRAW, clock-drawing), and memory (MEM, recalling name and address). An event marker noted question timing. RESULTS: Forty bilateral data sets were obtained (13 males, 37 right-hand dominant) with a median age of 31 years (IQR 22-52). Population normalized mean peak CBFv% in the dominant and non-dominant hemispheres, respectively, were: SUB7 (11.3±9.6%, 11.2±10.5%), N-P (12.7±11.7%, 11.5±12.0%), REP (12.9±11.7%, 11.6±11.6%), DRAW (13.3±11.7%, 13.2±15.4%) and MEM (13.2±10.3%, 12.0±10.1%). There was a significant difference between the dominant and non-dominant CBFv responses (p<0.008), but no difference between the amplitude of responses. COMPARISON WITH EXISTING METHODS: For established paradigms, our results are in excellent agreement to what has been found previously in the middle cerebral artery. CONCLUSIONS: Cognitive paradigms derived from the ACE-III led to significant lateralised changes in CBFv that were not distinct for novel paradigms. Further work is needed to assess the potential of paradigms to improve the interpretation of cognitive assessments in patients at risk of mild cognitive impairment.
[Mh] Termos MeSH primário: Velocidade do Fluxo Sanguíneo/fisiologia
Encéfalo/diagnóstico por imagem
Encéfalo/fisiologia
Circulação Cerebrovascular/fisiologia
Cognição/fisiologia
Acoplamento Neurovascular/fisiologia
Ultrassonografia Doppler Transcraniana/métodos
[Mh] Termos MeSH secundário: Adulto
Mapeamento Encefálico/métodos
Estudos de Viabilidade
Feminino
Seres Humanos
Interpretação de Imagem Assistida por Computador/métodos
Masculino
Projetos Piloto
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


  2 / 6700 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28449077
[Au] Autor:Jor'dan AJ; Poole VN; Iloputaife I; Milberg W; Manor B; Esterman M; Lipsitz LA
[Ad] Endereço:Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts.
[Ti] Título:Executive Network Activation is Linked to Walking Speed in Older Adults: Functional MRI and TCD Ultrasound Evidence From the MOBILIZE Boston Study.
[So] Source:J Gerontol A Biol Sci Med Sci;72(12):1669-1675, 2017 Nov 09.
[Is] ISSN:1758-535X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background: Changes in cerebral blood flow velocity (CBF) in response to a cognitive task (task-related ΔCBF) have been shown by Transcranial Doppler ultrasonography (TCD) to be reduced in slow walkers. However, it is unknown whether reduced task-related ΔCBF is associated with reduced neural activity in specific brain regions, as measured by blood-oxygen-level dependent (BOLD) functional magnetic resonance imaging (fMRI). Methods: We assessed the regional changes in neural activity associated with reduced middle cerebral artery (MCA) task-related ΔCBF to an executive task and slow walking speed in 67 community-dwelling older adults from the MOBILIZE Boston Study. Participants underwent walking assessments and TCD ultrasonography measures of MCA ΔCBF during the n-back task of executive function. A subset of participants (n = 27) completed the same task during fMRI. Individual BOLD activation maps for the n-back task were correlated with TCD measures and network-level averages were associated with TCD and preferred walking speed. Results: Participants with diminished task-related ΔCBF walked more slowly (ß = .39, p = .001). fMRI revealed significant associations between task-related ΔCBF and regional BOLD activation in several brain regions/networks supplied by the MCA. Of these regions and networks, those within the executive network were most strongly associated with walking speed (ß = .36, p = .01). Conclusions: Task-related ΔCBF during an executive function task is related to activation in several neural networks and impairment in the ability to recruit the executive network in particular is associated with slow walking speed in older adults.
[Mh] Termos MeSH primário: Circulação Cerebrovascular/fisiologia
Função Executiva/fisiologia
Imagem por Ressonância Magnética
Ultrassonografia Doppler Transcraniana
Velocidade de Caminhada/fisiologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Masculino
Rede Nervosa/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1093/gerona/glx063


  3 / 6700 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28463782
[Au] Autor:Zhang Q; Wang A; Zhang S; Li N; Chen S; Zhang Y; Zhou Y; Wu S; Zhao X
[Ad] Endereço:Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, China; Center of Stroke, Beijing Institute for Brain Disorders, China; Beijing Key Laboratory of Translational Medicine for Cerebrovascula
[Ti] Título:Asymptomatic polyvascular disease and the risks of cardiovascular events and all-cause death.
[So] Source:Atherosclerosis;262:1-7, 2017 Jul.
[Is] ISSN:1879-1484
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIMS: Atherosclerosis is a diffuse and systemic disease. We aimed to assess prevalence and outcome of extracoronary polyvascular disease (polyVD) in the asymptomatic Chinese community population. METHODS: A random sample of 5440 participants aged 40 years or older were enrolled in the Asymptomatic Polyvascular Abnormalities Community Study from 2010 to 2011. Intracranial artery stenosis, extracranial artery stenosis, and lower extremity artery disease were detected by transcranial Doppler and duplex sonography, and by calculating the ankle brachial index. The study endpoints included the first occurrence of stroke, myocardial infarction (MI) and all-cause death. RESULTS: PolyVD (two or three affected vascular territories) was found in 3.0% of the participants, and was significantly higher in men (4.3%). Over a median follow-up of 4.1 years, we identified a total of 247 events (4.7%), including 83 strokes (68 ischemic), 45 MIs and 134 all-cause deaths. After adjusting for age, gender and other potential confounders, we found a significant increase in risk of major cardiovascular events as well as all-cause death in participants with polyVD. In multivariate Cox regression analyses, the adjusted hazard ratios (HR) (95% confidence interval, CI) for the composite of stroke, MI and all-cause death for single and poly-vascular disease (compared with 0 vascular disease) increased from 1.58 (1.19-2.12) to 1.95 (1.26-3.03). Similarly, the adjusted HR (95% CI) for all-cause death for single and poly-vascular disease increased from 1.53 (1.03-2.29) to 2.22 (1.27-3.86). CONCLUSIONS: PolyVD significantly increased the risk of major cardiovascular events and all-cause death in the asymptomatic community population. Performing invasive screening tests for polyVD is useful in the high-risk asymptomatic population.
[Mh] Termos MeSH primário: Arteriopatias Oclusivas/epidemiologia
Doenças Arteriais Intracranianas/epidemiologia
Extremidade Inferior/irrigação sanguínea
Infarto do Miocárdio/epidemiologia
Doença Arterial Periférica/epidemiologia
Acidente Vascular Cerebral/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Índice Tornozelo-Braço
Arteriopatias Oclusivas/diagnóstico por imagem
Arteriopatias Oclusivas/mortalidade
Doenças Assintomáticas
Causas de Morte
Distribuição de Qui-Quadrado
China/epidemiologia
Progressão da Doença
Feminino
Seres Humanos
Doenças Arteriais Intracranianas/diagnóstico por imagem
Doenças Arteriais Intracranianas/mortalidade
Estimativa de Kaplan-Meier
Masculino
Meia-Idade
Análise Multivariada
Infarto do Miocárdio/diagnóstico
Infarto do Miocárdio/mortalidade
Doença Arterial Periférica/diagnóstico
Doença Arterial Periférica/mortalidade
Valor Preditivo dos Testes
Prognóstico
Modelos de Riscos Proporcionais
Estudos Prospectivos
Fatores de Risco
Acidente Vascular Cerebral/diagnóstico
Acidente Vascular Cerebral/mortalidade
Fatores de Tempo
Ultrassonografia Doppler Dupla
Ultrassonografia Doppler Transcraniana
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


  4 / 6700 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29206365
[Au] Autor:White JMB
[Ti] Título:Stroke Detector: Ultrasound and telemedicine could allow paramedics to confirm stroke.
[So] Source:JEMS;41(12):40-2, 2016 12.
[Is] ISSN:0197-2510
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Serviços Médicos de Emergência/métodos
Acidente Vascular Cerebral/diagnóstico por imagem
Telemedicina
Ultrassonografia Doppler Transcraniana
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:H
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE


  5 / 6700 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29247032
[Au] Autor:Miyazaki S; Watanabe T; Kajiyama T; Iwasawa J; Ichijo S; Nakamura H; Taniguchi H; Hirao K; Iesaka Y
[Ad] Endereço:From the Cardiovascular Center, Tsuchiura Kyodo Hospital, Tsuchiura, Ibaraki (S.M., T.W., T.K., J.I., S.I., H.N., H.T., Y.I.); and Heart Rhythm Center, Tokyo Medical and Dental University, Tokyo, Japan (K.H.). mshinsuke@k3.dion.ne.jp.
[Ti] Título:Thromboembolic Risks of the Procedural Process in Second-Generation Cryoballoon Ablation Procedures: Analysis From Real-Time Transcranial Doppler Monitoring.
[So] Source:Circ Arrhythm Electrophysiol;10(12), 2017 Dec.
[Is] ISSN:1941-3084
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Atrial fibrillation ablation is associated with substantial risks of silent cerebral events (SCEs) or silent cerebral lesions. We investigated which procedural processes during cryoballoon procedures carried a risk. METHODS AND RESULTS: Forty paroxysmal atrial fibrillation patients underwent pulmonary vein isolation using second-generation cryoballoons with single 28-mm balloon 3-minute freeze techniques. Microembolic signals (MESs) were monitored by transcranial Doppler throughout all procedures. Brain magnetic resonance imaging was obtained pre- and post-procedure in 34 patients (85.0%). Of 158 pulmonary veins, 152 (96.2%) were isolated using cryoablation, and 6 required touch-up radiofrequency ablation. A mean of 5.0±1.2 cryoballoon applications was applied, and the left atrial dwell time was 76.7±22.4 minutes. The total MES counts/procedures were 522 (426-626). Left atrial access and Flexcath sheath insertion generated 25 (11-44) and 34 (24-53) MESs. Using radiofrequency ablation for transseptal access increased the MES count during transseptal punctures. During cryoapplications, MES counts were greatest during first applications (117 [81-157]), especially after balloon stretch/deflations (43 [21-81]). Pre- and post-pulmonary vein potential mapping with Lasso catheters generated 57 (21-88) and 61 (36-88) MESs. Reinsertion of once withdrawn cryoballoons and subsequent applications produced 205 (156-310) MESs. Touch-up ablation generated 32 (19-62) MESs, whereas electric cardioversion generated no MESs. SCEs and silent cerebral lesions were detected in 11 (32.3%) and 4 (11.7%) patients, respectively. The patients with SCEs were older than those without; however, there were no significant factors associated with SCEs. CONCLUSIONS: A significant number of MESs and SCE/silent cerebral lesion occurrences were observed during second-generation cryoballoon ablation procedures. MESs were recorded during a variety of steps throughout the procedure; however, the majority occurred during phases with a high probability of gaseous emboli.
[Mh] Termos MeSH primário: Fibrilação Atrial/complicações
Fibrilação Atrial/cirurgia
Ablação por Cateter/métodos
Criocirurgia/métodos
Embolia Intracraniana/diagnóstico por imagem
Embolia Intracraniana/etiologia
Veias Pulmonares/cirurgia
Ultrassonografia Doppler Transcraniana
[Mh] Termos MeSH secundário: Fibrilação Atrial/fisiopatologia
Feminino
Fluoroscopia
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Fatores de Risco
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171222
[Lr] Data última revisão:
171222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE


  6 / 6700 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28818260
[Au] Autor:Spence JD
[Ad] Endereço:Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, Western University, 1400 Western Road, London, Ontario, Canada N6G 2V4. Electronic address: dspence@robarts.ca.
[Ti] Título:Transcranial Doppler monitoring for microemboli: a marker of a high-risk carotid plaque.
[So] Source:Semin Vasc Surg;30(1):62-66, 2017 Mar.
[Is] ISSN:1558-4518
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In the United States, 90% of carotid intervention is being performed for asymptomatic carotid stenosis, even though 90% of patients would be better treated with intensive medical therapy. This is being justified by comparing risks of stroke or death with medical therapy during clinical trials completed decades ago (approximately 2% per year) with risks of intervention with carotid artery stenting (CAS) versus carotid endarterectomy in recent trials that did not have a medical arm. Such extrapolations are, simply put, invalid. Even though the two most recent papers comparing carotid endarterectomy with CAS reported that the long-term risk (after first deducting periprocedural risks) is similar to that with medical therapy (approximately 0.5% per year), when the periprocedural risks are considered (approximately 3% with stenting v 1.5% with CAS), most patients would be better treated with intensive medical therapy. Furthermore, it must be recognized that the low risks observed in clinical trials with highly selected surgeons and interventionalists are much lower than in real-world practice. It is therefore necessary to have ways to identify, among patients with asymptomatic carotid stenosis, the few (approximately 10% to 15%) who could benefit from intervention. Indicators of vulnerable plaque, such as ulceration, juxtaluminal lucent plaque, intraplaque hemorrhage on magnetic resonance imaging, and plaque inflammation on positron emission tomography/computed tomography are in development for that purpose. The best-validated approach is detection of microemboli on transcranial Doppler. A prospective single-center study of 468 patients showed that microemboli identified high-risk asymptomatic stenosis; this was validated by a prospective multicenter international study in 467 patients. Increased risk with microemboli persisted in the era of lower risks with intensive medical therapy. Patients with asymptomatic carotid stenosis should not be offered CAS or carotid endarterectomy without first being identified as high risk; percent stenosis does not do so. Currently, the best way to improve the risk to benefit ratio for intervention is transcranial Doppler embolus detection.
[Mh] Termos MeSH primário: Artérias Carótidas/diagnóstico por imagem
Estenose das Carótidas/diagnóstico por imagem
Embolia Intracraniana/diagnóstico por imagem
Placa Aterosclerótica
Ultrassonografia Doppler Transcraniana
[Mh] Termos MeSH secundário: Angioplastia/instrumentação
Doenças Assintomáticas
Artérias Carótidas/patologia
Estenose das Carótidas/complicações
Estenose das Carótidas/patologia
Estenose das Carótidas/terapia
Progressão da Doença
Endarterectomia das Carótidas
Seres Humanos
Embolia Intracraniana/etiologia
Seleção de Pacientes
Valor Preditivo dos Testes
Prognóstico
Medição de Risco
Fatores de Risco
Ruptura Espontânea
Stents
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170819
[St] Status:MEDLINE


  7 / 6700 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28818140
[Au] Autor:Kurazumi T; Ogawa Y; Yanagida R; Morisaki H; Iwasaki KI
[Ti] Título:Dynamic Cerebral Autoregulation During the Combination of Mild Hypercapnia and Cephalad Fluid Shift.
[So] Source:Aerosp Med Hum Perform;88(9):819-826, 2017 Sep 01.
[Is] ISSN:2375-6314
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Mild hypercapnia combined with a cephalad fluid shift [e.g., that occurring during spaceflight or laparoscopic surgery with head-down tilt (HDT)] might affect cerebral autoregulation. However, no reports have described the effects of the combination on dynamic cerebral autoregulation. Therefore, we tested the hypothesis that the combination of mild hypercapnia and a cephalad fluid shift would attenuate dynamic cerebral autoregulation. METHODS: There were 15 healthy male volunteers who were exposed to 4 10-min protocols in which they received air in the supine position (Placebo/Supine), 3% carbon dioxide (CO2) in the supine position (CO2/Supine), air with -10° HDT (Placebo/HDT) and 3% CO2 with -10° HDT (CO2/HDT). Dynamic cerebral autoregulation was evaluated using a transfer function analysis of the beat-to-beat variability in mean arterial blood pressure (ABP) and mean cerebral blood flow (CBF) velocity. RESULTS: The phase in the low-frequency range was significantly lower during CO2/HDT than all other protocols, where CO2/HDT was -25% lower than Placebo/Supine (CO2/HDT, 0.49 ± 0.21; Placebo/Supine, 0.65 ± 0.16 radians). The transfer function gain in the low-frequency range was significantly higher during CO2/HDT than all other protocols, where CO2/HDT was 26% higher than Placebo/Supine (CO2/HDT, 1.08 ± 0.34; Placebo/Supine, 0.86 ± 0.28 cm · s-1 · mmHg-1). However, neither the CO2/Supine nor Placebo/HDT showed significant differences compared with the Placebo/Supine. DISCUSSION: Even short-term exposure to 3% CO2 plus HDT increased synchrony and the magnitude of transmission between ABP and CBF in the low-frequency range. Thus, the combination of mild hypercapnia and a cephalad fluid shift attenuated dynamic cerebral autoregulation.Kurazumi T, Ogawa Y, Yanagida R, Morisaki H, Iwasaki K. Dynamic cerebral autoregulation during the combination of mild hypercapnia and cephalad fluid shift. Aerosp Med Hum Perform. 2017; 88(9):819-826.
[Mh] Termos MeSH primário: Circulação Cerebrovascular/fisiologia
Deslocamentos de Líquidos Corporais/fisiologia
Decúbito Inclinado com Rebaixamento da Cabeça/fisiologia
Homeostase/fisiologia
Hipercapnia/fisiopatologia
[Mh] Termos MeSH secundário: Voluntários Saudáveis
Seres Humanos
Masculino
Ultrassonografia Doppler Transcraniana
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:170819
[St] Status:MEDLINE
[do] DOI:10.3357/AMHP.4870.2017


  8 / 6700 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28787394
[Au] Autor:Zamani S; Borhan Haghighi A; Haghpanah S; Karimi M; Bordbar MR
[Ad] Endereço:*Pediatric Department †Clinical Neurology Research Center ‡Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
[Ti] Título:Transcranial Doppler Screening in 50 Patients With Sickle Cell Hemoglobinopathies in Iran.
[So] Source:J Pediatr Hematol Oncol;39(7):506-512, 2017 Oct.
[Is] ISSN:1536-3678
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: As previous studies had discordant results with regard to the correlation of transcranial Doppler (TCD) screening and brain MRI, the aim of this study was to find the correlation between TCD values and silent ischemia in sickle cell disease (SCD) patients. METHOD AND MATERIALS: In this cross-sectional study, 50 patients with proven diagnosis of sickle cell hemoglobinopathies based on their hemoglobin electrophoresis were included. Demographic data, their physical exam, information with regard to crises history, and their laboratory data were recorded. Brain MRI and TCD were requested for all patients. RESULTS: The mean age of the patients was 10.2±5.8 years. Only 3 patients (6%) showed evidence of ischemia on brain MRI. Normal and ischemic patients were not significantly different with respect to TCD values, sex, splenomegaly, aplastic crisis, and laboratory test results (P-value >0.05). Only platelet count was significantly higher in the ischemic group compared with that in the normal group (P=0.002). The pain crisis was significantly associated with the mean velocity values of RMCA, LMCA, RV, and LV arteries (P-value <0.05). CONCLUSION: On the basis of our results, there was no significant difference in the mean velocity TCD values between patients with and without evidence of ischemic brain damage in brain MRI. The frequency of silent ischemia was much lower than expected. Further studies with larger sample sizes are needed to elucidate the positive predictive value of abnormal TCD in the prediction of silent ischemia in patients with sickle hemoglobinopathy in certain ethnic groups.
[Mh] Termos MeSH primário: Anemia Falciforme/complicações
Encéfalo/patologia
Ultrassonografia Doppler Transcraniana
[Mh] Termos MeSH secundário: Adolescente
Encéfalo/diagnóstico por imagem
Isquemia Encefálica/etiologia
Criança
Pré-Escolar
Estudos Transversais
Feminino
Hemoglobinopatias
Seres Humanos
Irã (Geográfico)
Imagem por Ressonância Magnética
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170809
[St] Status:MEDLINE
[do] DOI:10.1097/MPH.0000000000000890


  9 / 6700 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28771666
[Au] Autor:Brewin J; Kaya B; Chakravorty S
[Ad] Endereço:Department of Haematology, King's College London, London, UK.
[Ti] Título:How I manage sickle cell patients with high transcranial doppler results.
[So] Source:Br J Haematol;179(3):377-388, 2017 Nov.
[Is] ISSN:1365-2141
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Stroke is one of the most severe complications to affect children with sickle cell anaemia (SCA). Transcranial doppler (TCD) is an accurate and non-invasive method to determine stroke risk. Randomised controlled trials have demonstrated the efficacy of chronic transfusion therapy in stroke prevention based on risk stratification determined by TCD velocities. This has led to the regular use of TCD monitoring for children with SCA in order to determine stroke risk. Significant resource allocation is necessary to facilitate training, quality assurance and failsafe arrangements for non-attenders. In a subgroup of patients, chronic transfusions for primary stroke prevention can be replaced by hydroxycarbamide therapy, provided careful monitoring is undertaken; including repeat TCD studies at frequent intervals. The authors propose an evidence-based algorithm for the management of abnormal TCD velocities and discuss the role of this test in other clinical contexts, such as in Haemoglobin SC disease.
[Mh] Termos MeSH primário: Anemia Falciforme/complicações
Anemia Falciforme/diagnóstico por imagem
Encéfalo/diagnóstico por imagem
Acidente Vascular Cerebral/diagnóstico por imagem
Acidente Vascular Cerebral/etiologia
[Mh] Termos MeSH secundário: Anemia Falciforme/terapia
Velocidade do Fluxo Sanguíneo/fisiologia
Transfusão de Sangue/métodos
Circulação Cerebrovascular/fisiologia
Seres Humanos
Medição de Risco/métodos
Acidente Vascular Cerebral/prevenção & controle
Ultrassonografia Doppler Transcraniana/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.1111/bjh.14850


  10 / 6700 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28730452
[Au] Autor:Graziadei G; Casoni FM; Annoni F; Cortinovis I; Ridolfi P; Gandolfi I; Marcon A; Di Pierro E; Cappellini MD
[Ad] Endereço:U.O. Medicina Interna, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Francesco Sforza, 35, 20122, Milan, Italy. giovanna.graziadei@policlinico.mi.it.
[Ti] Título:Transcranial color Doppler in stroke-free adult patients with sickle cell disease.
[So] Source:Ann Hematol;96(9):1547-1555, 2017 Sep.
[Is] ISSN:1432-0584
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The threshold velocity ≥200 cm/s at transcranial Doppler (TCD) evaluation is a useful cut-off for preventing the stroke (STOP trial) in pediatric patients with sickle cell disease (SCD), term including different types of sickle genotypes. Scanty data are available for adult SCD patients. We compared intracranial blood flow velocities between adult SCD patients and controls using transcranial color Doppler (TCCD), measuring the peak of systolic velocity (PSV) with the insonation angle correction and the pulsatility index (PI), an indicator of endothelial elasticity. Fifty-three adult SCD patients (aged >18 years) were enrolled (15 sickle cell anemia, 26 sickle cell thalassemia, and 12 HbS/HbC). None of the patients presented neurological signs. PSVs in middle cerebral artery (MCA) were higher in SCD patients than in controls (p = 0.001). In sickle cell anemia patients, PSVs were higher when compared to HbS/ßThal (p < 0.0060) and HbS/HbC patients (p < 0.0139). PI was within the lower range of normality in SCD patients compared to controls. Moreover, MCA-PSV was higher with lower Hb levels and higher HbS%; PI did not change with variation of Hb levels and HbS%.PSV and PI in SCD adult patients could be a relevant index to indicate the abnormal cerebral blood flow and to detect the sickle endothelial damage, in order to prevent cerebrovascular accidents.
[Mh] Termos MeSH primário: Anemia Falciforme/diagnóstico por imagem
Ultrassonografia Doppler Transcraniana
[Mh] Termos MeSH secundário: Adulto
Anemia Falciforme/complicações
Anemia Falciforme/genética
Velocidade do Fluxo Sanguíneo
Estudos de Casos e Controles
Feminino
Seres Humanos
Masculino
Acidente Vascular Cerebral/diagnóstico por imagem
Acidente Vascular Cerebral/etiologia
Acidente Vascular Cerebral/genética
Acidente Vascular Cerebral/prevenção & controle
Talassemia beta/complicações
Talassemia beta/diagnóstico por imagem
Talassemia beta/genética
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170722
[St] Status:MEDLINE
[do] DOI:10.1007/s00277-017-3071-1



página 1 de 670 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde