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  1 / 8752 MEDLINE  
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[PMID]:29269594
[Au] Autor:Liebi M; Georgiadis M; Kohlbrecher J; Holler M; Raabe J; Usov I; Menzel A; Schneider P; Bunk O; Guizar-Sicairos M
[Ad] Endereço:Paul Scherrer Institut, 5232 Villigen PSI, Switzerland.
[Ti] Título:Small-angle X-ray scattering tensor tomography: model of the three-dimensional reciprocal-space map, reconstruction algorithm and angular sampling requirements.
[So] Source:Acta Crystallogr A Found Adv;74(Pt 1):12-24, 2018 Jan 01.
[Is] ISSN:2053-2733
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Small-angle X-ray scattering tensor tomography, which allows reconstruction of the local three-dimensional reciprocal-space map within a three-dimensional sample as introduced by Liebi et al. [Nature (2015), 527, 349-352], is described in more detail with regard to the mathematical framework and the optimization algorithm. For the case of trabecular bone samples from vertebrae it is shown that the model of the three-dimensional reciprocal-space map using spherical harmonics can adequately describe the measured data. The method enables the determination of nanostructure orientation and degree of orientation as demonstrated previously in a single momentum transfer q range. This article presents a reconstruction of the complete reciprocal-space map for the case of bone over extended ranges of q. In addition, it is shown that uniform angular sampling and advanced regularization strategies help to reduce the amount of data required.
[Mh] Termos MeSH primário: Algoritmos
Osso e Ossos/diagnóstico por imagem
Tomografia/métodos
Difração de Raios X
[Mh] Termos MeSH secundário: Seres Humanos
Imagem Tridimensional
Nanoestruturas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171223
[St] Status:MEDLINE
[do] DOI:10.1107/S205327331701614X


  2 / 8752 MEDLINE  
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[PMID]:28452241
[Au] Autor:Theerawit P; Sutherasan Y; Ball L; Pelosi P
[Ad] Endereço:a Division of Pulmonary and Critical Care Medicine, Department of Medicine, Faculty of Medicine Ramathibodi Hospital , Mahidol University , Bangkok , Thailand.
[Ti] Título:Respiratory monitoring in adult intensive care unit.
[So] Source:Expert Rev Respir Med;11(6):453-468, 2017 Jun.
[Is] ISSN:1747-6356
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The mortality of patients with respiratory failure has steadily decreased with the advancements in protective ventilation and treatment options. Although respiratory monitoring per se has not been proven to affect the mortality of critically ill patients, it plays a crucial role in patients' care, as it helps to titrate the ventilatory support. Several new monitoring techniques have recently been made available at the bedside. The goals of monitoring comprise alerting physicians to detect the change in the patients' conditions, to improve the understanding of pathophysiology to guide the diagnosis and provide cost-effective clinical management. Areas covered: We performed a review of the recent scientific literature to provide an overview of the different methods used for respiratory monitoring in adult intensive care units, including bedside imaging techniques such as ultrasound and electrical impedance tomography. Expert commentary: Appropriate respiratory monitoring plays an important role in patients with and without respiratory failure as a guiding tool for the optimization of ventilation support, avoiding further complications and decreasing morbidity and mortality. The physician should tailor the monitoring strategy for each individual patient and know how to correctly interpret the data.
[Mh] Termos MeSH primário: Unidades de Terapia Intensiva
Pulmão/fisiopatologia
Monitorização Fisiológica/métodos
Respiração Artificial
Insuficiência Respiratória/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Estado Terminal
Impedância Elétrica
Seres Humanos
Insuficiência Respiratória/mortalidade
Insuficiência Respiratória/fisiopatologia
Tomografia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1080/17476348.2017.1325324


  3 / 8752 MEDLINE  
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[PMID]:28742775
[Au] Autor:da Silva Ramos FJ; Hovnanian A; Souza R; Azevedo LCP; Amato MBP; Costa ELV
[Ti] Título:Estimation of Stroke Volume and Stroke Volume Changes by Electrical Impedance Tomography.
[So] Source:Anesth Analg;126(1):102-110, 2018 01.
[Is] ISSN:1526-7598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Electrical impedance tomography (EIT) is a noninvasive imaging method that identifies changes in air and blood volume based on thoracic impedance changes. Recently, there has been growing interest in EIT to measure stroke volume (SV). The objectives of this study are as follows: (1) to evaluate the ability of systolic impedance variations (ΔZsys) to track changes in SV in relation to a baseline condition; (2) to assess the relationship of ΔZsys and SV in experimental subjects; and (3) to identify the influence of body dimensions on the relationship between ΔZsys and SV. METHODS: Twelve Agroceres pigs were instrumented with transpulmonary thermodilution catheter and EIT and were mechanically ventilated in a random order using different settings of tidal volume (VT) and positive end-expiratory pressure (PEEP): VT 10 mL·kg and PEEP 10 cm H2O, VT 10 mL·kg and PEEP 5 cm H2O, VT 6 mL·kg and PEEP 10 cm H2O, and VT 6 mL·kg and PEEP 5 cm H2O. After baseline data collection, subjects were submitted to hemorrhagic shock and successive fluid challenges. RESULTS: A total of 204 paired measurements of SV and ΔZsys were obtained. The 4-quadrant plot showed acceptable trending ability with a concordance rate of 91.2%. Changes in ΔZsys after fluid challenges presented an area under the curve of 0.83 (95% confidence interval, 0.74-0.92) to evaluate SV changes. Conversely, the linear association between ΔZsys and SV was poor, with R from linear mixed model of 0.35. Adding information on body dimensions improved the linear association between ΔZsys and SV up to R from linear mixed model of 0.85. CONCLUSIONS: EIT showed good trending ability and is a promising hemodynamic monitoring tool. Measurements of absolute SV require that body dimensions be taken into account.
[Mh] Termos MeSH primário: Impedância Elétrica
Volume Sistólico/fisiologia
Tomografia/métodos
[Mh] Termos MeSH secundário: Animais
Estudos Cross-Over
Feminino
Respiração com Pressão Positiva/métodos
Distribuição Aleatória
Choque Hemorrágico/diagnóstico por imagem
Choque Hemorrágico/fisiopatologia
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1213/ANE.0000000000002271


  4 / 8752 MEDLINE  
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[PMID]:29206856
[Au] Autor:Martin S; Choi CTM
[Ad] Endereço:Department of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu, Taiwan.
[Ti] Título:A novel post-processing scheme for two-dimensional electrical impedance tomography based on artificial neural networks.
[So] Source:PLoS One;12(12):e0188993, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Electrical Impedance Tomography (EIT) is a powerful non-invasive technique for imaging applications. The goal is to estimate the electrical properties of living tissues by measuring the potential at the boundary of the domain. Being safe with respect to patient health, non-invasive, and having no known hazards, EIT is an attractive and promising technology. However, it suffers from a particular technical difficulty, which consists of solving a nonlinear inverse problem in real time. Several nonlinear approaches have been proposed as a replacement for the linear solver, but in practice very few are capable of stable, high-quality, and real-time EIT imaging because of their very low robustness to errors and inaccurate modeling, or because they require considerable computational effort. METHODS: In this paper, a post-processing technique based on an artificial neural network (ANN) is proposed to obtain a nonlinear solution to the inverse problem, starting from a linear solution. While common reconstruction methods based on ANNs estimate the solution directly from the measured data, the method proposed here enhances the solution obtained from a linear solver. CONCLUSION: Applying a linear reconstruction algorithm before applying an ANN reduces the effects of noise and modeling errors. Hence, this approach significantly reduces the error associated with solving 2D inverse problems using machine-learning-based algorithms. SIGNIFICANCE: This work presents radical enhancements in the stability of nonlinear methods for biomedical EIT applications.
[Mh] Termos MeSH primário: Impedância Elétrica
Redes Neurais (Computação)
Tomografia/métodos
[Mh] Termos MeSH secundário: Seres Humanos
Imagens de Fantasmas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188993


  5 / 8752 MEDLINE  
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[PMID]:29176834
[Au] Autor:Wieczorek A; Dulski K; Niedzwiecki S; Alfs D; Bialas P; Curceanu C; Czerwinski E; Danel A; Gajos A; Glowacz B; Gorgol M; Hiesmayr B; Jasinska B; Kacprzak K; Kaminska D; Kaplon L; Kochanowski A; Korcyl G; Kowalski P; Kozik T; Krzemien W; Kubicz E; Kucharek M; Mohammed M; Pawlik-Niedzwiecka M; Palka M; Raczynski L; Rudy Z; Rundel O; Sharma NG; Silarski M; Uchacz T; Wislicki W; Zgardzinska B; Zielinski M; Moskal P
[Ad] Endereço:Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland.
[Ti] Título:Novel scintillating material 2-(4-styrylphenyl)benzoxazole for the fully digital and MRI compatible J-PET tomograph based on plastic scintillators.
[So] Source:PLoS One;12(11):e0186728, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A novel plastic scintillator is developed for the application in the digital positron emission tomography (PET). The novelty of the concept lies in application of the 2-(4-styrylphenyl)benzoxazole as a wavelength shifter. The substance has not been used as scintillator dopant before. A dopant shifts the scintillation spectrum towards longer wavelengths making it more suitable for applications in scintillators of long strips geometry and light detection with digital silicon photomultipliers. These features open perspectives for the construction of the cost-effective and MRI-compatible PET scanner with the large field of view. In this article we present the synthesis method and characterize performance of the elaborated scintillator by determining its light emission spectrum, light emission efficiency, rising and decay time of the scintillation pulses and resulting timing resolution when applied in the positron emission tomography. The optimal concentration of the novel wavelength shifter was established by maximizing the light output and it was found to be 0.05 ‰ for cuboidal scintillator with dimensions of 14 mm x 14 mm x 20 mm.
[Mh] Termos MeSH primário: Benzoxazóis/química
Imagem por Ressonância Magnética
Tomografia por Emissão de Pósitrons
Contagem de Cintilação/instrumentação
Estirenos/química
Tomografia
[Mh] Termos MeSH secundário: Luz
Peso Molecular
Polimerização
Espectrometria de Fluorescência
Temperatura Ambiente
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzoxazoles); 0 (Styrenes)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186728


  6 / 8752 MEDLINE  
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[PMID]:28467324
[Au] Autor:Them K
[Ad] Endereço:Section for Biomedical Imaging, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg. Institute for Biomedical Imaging, Hamburg University of Technology, Schwarzenbergstrasse 95, 21073 Hamburg, Germany.
[Ti] Título:On magnetic dipole-dipole interactions of nanoparticles in magnetic particle imaging.
[So] Source:Phys Med Biol;62(14):5623-5639, 2017 Jun 14.
[Is] ISSN:1361-6560
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Magnetic dipole-dipole (MDD) interactions between iron oxide nanoparticles can influence the sensitivity, image resolution and quantification of magnetic particle imaging (MPI). For the first time, the Landau-Lifshitz-Gilbert equation (LLG) for MDD interactions has been solved to investigate the effect of MDD interactions on the MPI spectrum. It was found that at concentrations above 39 mmol(Fe) l , MDD interactions significantly influence MPI spectra. This influence increases with increasing harmonics, which means first harmonics should be preferred for iron quantification. Since ≈10 particles are neglected in the LLG compared to in an MPI experiment, the calculated limit below which MDD interactions can be neglected is only a bound. The true limit is therefore below the calculated limit of 39 mmol(Fe) l , because all other neglected particles also contribute to deviations in the MPI spectra via MDD interactions. Therefore, a quantum mechanical bound on the influence of MDD interactions is calculated, including up to 10 particles. Analysis of the bound as a function of the particle number provides a valuable insight into the influence of the large number of particles neglected in numerical simulations. Both results are compared with concentrations in biomedical MPI experiments. We conclude that the standard approximation of an absence of MDD interactions in MPI experiments must be handled more carefully. Our method of incorporating MDD interactions into the LLG can be easily implemented as part of model-based reconstruction to increase the sensitivity, image resolution and quantitative tracer detection during MPI.
[Mh] Termos MeSH primário: Compostos Férricos/química
Imãs/química
Nanopartículas
Fenômenos Físicos
Tomografia/métodos
[Mh] Termos MeSH secundário: Processamento de Imagem Assistida por Computador
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ferric Compounds); 1K09F3G675 (ferric oxide)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171211
[Lr] Data última revisão:
171211
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1088/1361-6560/aa70ca


  7 / 8752 MEDLINE  
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[PMID]:27775928
[Au] Autor:Eroglu HH; Eyüboglu BM
[Ad] Endereço:Department of Electrical and Electronics Engineering, Middle East Technical University, 06800 Ankara, Turkey.
[Ti] Título:Two alternatives for magnetic resonance electrical impedance tomography: injected or induced current.
[So] Source:Physiol Meas;37(11):2024-2049, 2016 Nov.
[Is] ISSN:1361-6579
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this paper, the abilities of injected current magnetic resonance electrical impedance tomography (MREIT) and induced current magnetic resonance electrical impedance tomography (ICMREIT) systems to differentiate a conductivity perturbation from an otherwise uniform conductivity distribution are compared. The sensitivity of MREIT measurements changes as a function of distance to the electrodes used for current injection. The sensitivity of ICMREIT measurements is related to the radial location, being a minimum for concentrically located small conductivity perturbations. The very low sensitivity of ICMREIT to conductivity perturbations at central locations seems to be the major drawback of the method compared with MREIT. When the diameter of a concentric and/or an eccentric circular conductivity inhomogeneity inside an otherwise homogeneous circular conductor is close to half of the diameter of the conductor region, the distinguishability of the perturbation by MREIT increases. MREIT is more sensitive to perturbations with lower conductivity with respect to background conductivity (resistive perturbations) than to conductive perturbations. In the case of ICMREIT, concentric inhomogeneities are equally distinguishable for conductive and resistive conductivity perturbations. Eccentric resistive inhomogeneities are more distinguishable then conductive inhomogeneities. Distinguishability increases with the size and number of conductivity perturbations.
[Mh] Termos MeSH primário: Tomografia/métodos
[Mh] Termos MeSH secundário: Impedância Elétrica
Injeções
Espectroscopia de Ressonância Magnética
Tomografia/instrumentação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171130
[Lr] Data última revisão:
171130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161105
[St] Status:MEDLINE


  8 / 8752 MEDLINE  
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[PMID]:28957389
[Au] Autor:Martínez-Martínez N; Martínez-Alonso E; Tomás M; Neumüller J; Pavelka M; Martínez-Menárguez JA
[Ad] Endereço:Department of Cell Biology and Histology, Biomedical Research Institute of Murcia (IMIB-Arrixaca-UMU), University of Murcia, Murcia, Spain.
[Ti] Título:A new insight into the three-dimensional architecture of the Golgi complex: Characterization of unusual structures in epididymal principal cells.
[So] Source:PLoS One;12(9):e0185557, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Principal epididymal cells have one of the largest and more developed Golgi complex of mammalian cells. In the present study, we have used this cell as model for the study of the three-dimensional architecture of the Golgi complex of highly secretory and endocytic cells. Electron tomography demonstrated the presence in this cell type of some unknown or very unusual Golgi structures such as branched cisternae, pocket-like cisternal invaginations or tubular connections. In addition, we have used this methodology and immunoelectron microscopy to analyze the close relationship between this organelle and both the endoplasmic reticulum and microtubules, and to describe in detail how these elements interact with compact and non-compact regions of the ribbon.
[Mh] Termos MeSH primário: Epididimo/metabolismo
Complexo de Golgi/metabolismo
[Mh] Termos MeSH secundário: Animais
Epididimo/citologia
Complexo de Golgi/ultraestrutura
Masculino
Microscopia Eletrônica
Ratos Sprague-Dawley
Tomografia/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170929
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185557


  9 / 8752 MEDLINE  
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[PMID]:28890085
[Au] Autor:Bäuerlein FJB; Saha I; Mishra A; Kalemanov M; Martínez-Sánchez A; Klein R; Dudanova I; Hipp MS; Hartl FU; Baumeister W; Fernández-Busnadiego R
[Ad] Endereço:Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
[Ti] Título:In Situ Architecture and Cellular Interactions of PolyQ Inclusions.
[So] Source:Cell;171(1):179-187.e10, 2017 Sep 21.
[Is] ISSN:1097-4172
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Expression of many disease-related aggregation-prone proteins results in cytotoxicity and the formation of large intracellular inclusion bodies. To gain insight into the role of inclusions in pathology and the in situ structure of protein aggregates inside cells, we employ advanced cryo-electron tomography methods to analyze the structure of inclusions formed by polyglutamine (polyQ)-expanded huntingtin exon 1 within their intact cellular context. In primary mouse neurons and immortalized human cells, polyQ inclusions consist of amyloid-like fibrils that interact with cellular endomembranes, particularly of the endoplasmic reticulum (ER). Interactions with these fibrils lead to membrane deformation, the local impairment of ER organization, and profound alterations in ER membrane dynamics at the inclusion periphery. These results suggest that aberrant interactions between fibrils and endomembranes contribute to the deleterious cellular effects of protein aggregation. VIDEO ABSTRACT.
[Mh] Termos MeSH primário: Doença de Huntington/patologia
Corpos de Inclusão/patologia
Neurônios/patologia
Neurônios/ultraestrutura
Peptídeos/metabolismo
[Mh] Termos MeSH secundário: Amiloide/química
Animais
Microscopia Crioeletrônica
Retículo Endoplasmático/metabolismo
Retículo Endoplasmático/patologia
Feminino
Células HeLa
Seres Humanos
Proteína Huntingtina/genética
Proteína Huntingtina/metabolismo
Corpos de Inclusão/química
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Microscopia Eletrônica de Transmissão
Mutação
Agregação Patológica de Proteínas
Tomografia/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amyloid); 0 (HTT protein, human); 0 (Huntingtin Protein); 0 (Peptides); 26700-71-0 (polyglutamine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170912
[St] Status:MEDLINE


  10 / 8752 MEDLINE  
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[PMID]:28886374
[Au] Autor:Szewczak L
[Ti] Título:Seeing DNA Where It Lives.
[So] Source:Cell;170(6):1045-1047, 2017 Sep 07.
[Is] ISSN:1097-4172
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:It's the stuff of life, and we're fascinated by DNA and how it's packaged into chromatin and compacted into chromosomes. Advances in looking at chromatin organization in cells are letting us see this polymer, its packing, and its function with fresh eyes.
[Mh] Termos MeSH primário: Cromatina/química
Cromatina/ultraestrutura
Microscopia Crioeletrônica/métodos
Empacotamento do DNA
Tomografia/métodos
[Mh] Termos MeSH secundário: Animais
Núcleo Celular/química
Núcleo Celular/ultraestrutura
Cromossomos/química
Cromossomos/ultraestrutura
DNA/química
Seres Humanos
Nucleossomos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chromatin); 0 (Nucleosomes); 9007-49-2 (DNA)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE



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