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[PMID]:29381754
[Au] Autor:Benmassaoud A; Ghali P; Cox J; Wong P; Szabo J; Deschenes M; Osikowicz M; Lebouche B; Klein MB; Sebastiani G
[Ad] Endereço:Division of Gastroenterology and Hepatology, Royal Victoria Hospital, McGill University Health Centre, Montreal, Canada.
[Ti] Título:Screening for nonalcoholic steatohepatitis by using cytokeratin 18 and transient elastography in HIV mono-infection.
[So] Source:PLoS One;13(1):e0191985, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIM: HIV-infected individuals are at high risk of developing nonalcoholic steatohepatitis (NASH), a leading cause of end-stage liver disease in Western countries. Nonetheless, due to the invasiveness of liver biopsy, NASH remains poorly understood in HIV mono-infection. We aimed to characterize the prevalence and predictors of NASH in unselected HIV mono-infected patients by means of non-invasive diagnostic tools. METHODS: HIV-infected adults without significant alcohol intake or co-infection with hepatitis B or C underwent a routine screening program employing transient elastography (TE) with controlled attenuation parameter (CAP) and the serum biomarker cytokeratin-18 (CK-18). NASH was diagnosed non-invasively as the coexistence of fatty liver (CAP ≥248 dB/m) and CK-18 >246 U/L. Identified cases of NASH were offered a diagnostic liver biopsy. Predictors of NASH were determined by multivariate logistic regression analysis. RESULTS: 202 consecutive HIV mono-infected patients were included. NASH was non-invasively diagnosed in 23 cases (11.4%). Among them, 17 underwent a liver biopsy, and histology confirmed NASH in all cases. The prevalence of NASH was higher in patients with hypertriglyceridemia (17.1%), insulin resistance defined by homeostasis model for assessment of insulin resistance (HOMA-IR) (25%), those with detectable HIV viral load (42.9%) and those with elevated ALT (53.6%). After adjustment, higher HOMA-IR (adjusted odds ratio [aOR] = 1.20, 95% CI 1.01-1.43; p = 0.03) and ALT (aOR = 2.39, 95% CI 1.50-3.79; p<0.001) were independent predictors of NASH. CONCLUSIONS: NASH, diagnosed by a non-invasive diagnostic approach employing CK-18 and TE with CAP, is common in unselected HIV mono-infected individuals, particularly in the presence of insulin resistance and elevated ALT.
[Mh] Termos MeSH primário: Infecções por HIV/complicações
Queratina-18/metabolismo
Hepatopatia Gordurosa não Alcoólica/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Estudos Transversais
Técnicas de Imagem por Elasticidade
Feminino
Seres Humanos
Masculino
Meia-Idade
Hepatopatia Gordurosa não Alcoólica/complicações
Hepatopatia Gordurosa não Alcoólica/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Keratin-18)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180131
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191985


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[PMID]:28471737
[Au] Autor:Walter BA; Mageswaran P; Mo X; Boulter DJ; Mashaly H; Nguyen XV; Prevedello LM; Thoman W; Raterman BD; Kalra P; Mendel E; Marras WS; Kolipaka A
[Ad] Endereço:From the Spine Research Institute (B.A.W., P.M., H.M., W.T., E.M., W.S.M., A.K.), Department of Biomedical Engineering (B.A.W., A.K.), Department of Integrated Systems Engineering (P.M., W.S.M.), and Department of Biomedical Informatics (X.M.), the Ohio State University, 395 W 12th Ave, 4th Floor Ra
[Ti] Título:MR Elastography-derived Stiffness: A Biomarker for Intervertebral Disc Degeneration.
[So] Source:Radiology;285(1):167-175, 2017 Oct.
[Is] ISSN:1527-1315
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose To determine the repeatability of magnetic resonance (MR) elastography-derived shear stiffness measurements of the intervertebral disc (IVD) taken throughout the day and their relationship with IVD degeneration and subject age. Materials and Methods In a cross-sectional study, in vivo lumbar MR elastography was performed once in the morning and once in the afternoon in 47 subjects without current low back pain (IVDs = 230; age range, 20-71 years) after obtaining written consent under approval of the institutional review board. The Pfirrmann degeneration grade and MR elastography-derived shear stiffness of the nucleus pulposus and annulus fibrosus regions of all lumbar IVDs were assessed by means of principal frequency analysis. One-way analysis of variance, paired t tests, concordance and Bland-Altman tests, and Pearson correlations were used to evaluate degeneration, diurnal changes, repeatability, and age effects, respectively. Results There were no significant differences between morning and afternoon shear stiffness across all levels and there was very good technical repeatability between the morning and afternoon imaging results for both nucleus pulposus (R = 0.92) and annulus fibrosus (R = 0.83) regions. There was a significant increase in both nucleus pulposus and annulus fibrosus MR elastography-derived shear stiffness with increasing Pfirrmann degeneration grade (nucleus pulposus grade 1, 12.5 kPa ± 1.3; grade 5, 16.5 kPa ± 2.1; annulus fibrosus grade 1, 90.4 kPa ± 9.3; grade 5, 120.1 kPa ± 15.4), and there were weak correlations between shear stiffness and age across all levels (R ≤ 0.32). Conclusion Our results demonstrate that MR elastography-derived shear stiffness measurements are highly repeatable, weakly correlate with age, and increase with advancing IVD degeneration. These results suggest that MR elastography-derived shear stiffness may provide an objective biomarker of the IVD degeneration process. RSNA, 2017 Online supplemental material is available for this article.
[Mh] Termos MeSH primário: Técnicas de Imagem por Elasticidade/métodos
Degeneração do Disco Intervertebral/diagnóstico por imagem
Disco Intervertebral/diagnóstico por imagem
Imagem por Ressonância Magnética/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Biomarcadores
Estudos Transversais
Seres Humanos
Interpretação de Imagem Assistida por Computador
Disco Intervertebral/fisiopatologia
Degeneração do Disco Intervertebral/fisiopatologia
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1148/radiol.2017162287


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[PMID]:29293628
[Au] Autor:Chen SH; Lai HC; Chiang IP; Su WP; Lin CH; Kao JT; Chuang PH; Hsu WF; Wang HW; Chen HY; Huang GT; Peng CY
[Ad] Endereço:Graduate Institute of Clinical Medical Science, School of Medicine, China Medical University, Taichung, Taiwan.
[Ti] Título:Changes in liver stiffness measurement using acoustic radiation force impulse elastography after antiviral therapy in patients with chronic hepatitis C.
[So] Source:PLoS One;13(1):e0190455, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To compare on-treatment and off-treatment parameters acquired using acoustic radiation force impulse elastography, the Fibrosis-4 (FIB-4) index, and aspartate aminotransferase-to-platelet ratio index (APRI) in patients with chronic hepatitis C (CHC). METHODS: Patients received therapies based on pegylated interferon or direct-acting antiviral agents. The changes in paired patient parameters, including liver stiffness (LS) values, the FIB-4 index, and APRI, from baseline to sustained virologic response (SVR) visit (24 weeks after the end of treatment) were compared. Multiple regression models were used to identify significant factors that explained the correlations with LS, FIB-4, and APRI values and SVR. RESULTS: A total of 256 patients were included, of which 219 (85.5%) achieved SVR. The paired LS values declined significantly from baseline to SVR visit in all groups and subgroups except the nonresponder subgroup (n = 10). Body mass index (P = 0.0062) and baseline LS (P < 0.0001) were identified as independent factors that explained the LS declines. Likewise, the baseline FIB-4 (P < 0.0001) and APRI (P < 0.0001) values independently explained the declines in the FIB-4 index and APRI, respectively. Moreover, interleukin-28B polymorphisms, baseline LS, and rapid virologic response were identified as independent correlates with SVR. CONCLUSIONS: Paired LS measurements in patients treated for CHC exhibited significant declines comparable to those in FIB-4 and APRI values. These declines may have correlated with the resolution of necroinflammation. Baseline LS values predicted SVR.
[Mh] Termos MeSH primário: Antivirais/uso terapêutico
Técnicas de Imagem por Elasticidade/métodos
Hepatite C Crônica/tratamento farmacológico
Fígado/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Hepatite C Crônica/fisiopatologia
Seres Humanos
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antiviral Agents)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190455


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[PMID]:29194972
[Au] Autor:Evans WN; Acherman RJ; Ciccolo ML; Carrillo SA; Galindo A; Rothman A; Mayman GA; Adams EA; Reardon LC; Winn BJ; Yumiaco NS; Shimuizu L; Inanaga Y; Deleon RJ; Restrepo H
[Ad] Endereço:Department of Pediatric Cardiology, Children's Heart Center Nevada, Las Vegas, Nevada, USA.
[Ti] Título:A composite noninvasive index correlates with liver fibrosis scores in post-Fontan patients: Preliminary findings.
[So] Source:Congenit Heart Dis;13(1):38-45, 2018 Jan.
[Is] ISSN:1747-0803
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: We hypothesized that clinic-based, hepatic-ultrasound, elastography measurements, either alone or in combination with other noninvasive variables, might correlate with liver-biopsy fibrosis scores in patients post-Fontan. METHODS: Between March 2012 and February 2017, we identified patients post-Fontan that underwent elective cardiac catheterization and simultaneous transvenous hepatic biopsy. From this group, we selected patients that met inclusion criteria for liver-ultrasound, shear-wave elastography. Utilizing the results of elastography, laboratory testing, and time post-Fontan, we constructed a composite Fontan hepatic index as a sum of elastography measurements in kilopascals, model for end-stage liver disease excluding INR scores, and the square root of the number of years post-Fontan. Further, we analyzed correlations between Fontan hepatic index values and fibrosis scores from hepatic biopsy. RESULTS: We identified a total of 79 post-Fontan patients that underwent cardiac catheterization and liver biopsy. Of the 79 patients, 53 met inclusion criteria, and 32 consented to undergo hepatic-ultrasound elastography. Of the 32 that underwent elastography, data from 30 patients was used for analysis. We found no statistically significant differences in demographics, laboratory values, or cardiac catheterization data between the 30 included patients and the 21 that did not participate. Utilizing data from the 30 included patients, we found a strong, highly statistically significant correlation between the Fontan hepatic index values and total fibrosis scores (R = 0.8, P < .00001). However, the cohort size prevented reliable discriminating cut-off values for the range of total fibrosis scores. CONCLUSIONS: In a small cohort of patients post-Fontan, preliminary findings suggest that the composite Fontan hepatic index might be a clinically useful, noninvasive method of serially monitoring for hepatic fibrosis. Further studies, with large patient cohorts, are necessary to validate our findings and develop clinically useful discriminatory cutoff values.
[Mh] Termos MeSH primário: Técnica de Fontan/efeitos adversos
Cirrose Hepática/diagnóstico
Fígado/diagnóstico por imagem
Complicações Pós-Operatórias
[Mh] Termos MeSH secundário: Adolescente
Adulto
Biópsia
Criança
Técnicas de Imagem por Elasticidade/métodos
Feminino
Seguimentos
Cardiopatias Congênitas/cirurgia
Seres Humanos
Cirrose Hepática/etiologia
Masculino
Meia-Idade
Estudos Retrospectivos
Índice de Gravidade de Doença
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.1111/chd.12558


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[PMID]:29293527
[Au] Autor:Mulabecirovic A; Mjelle AB; Gilja OH; Vesterhus M; Havre RF
[Ad] Endereço:Department of Clinical Medicine, University of Bergen, Bergen, Norway.
[Ti] Título:Repeatability of shear wave elastography in liver fibrosis phantoms-Evaluation of five different systems.
[So] Source:PLoS One;13(1):e0189671, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study aimed to assess and validate the repeatability and agreement of quantitative elastography of novel shear wave methods on four individual tissue-mimicking liver fibrosis phantoms with different known Young's modulus. We used GE Logiq E9 2D-SWE, Philips iU22 ARFI (pSWE), Samsung TS80A SWE (pSWE), Hitachi Ascendus (SWM) and Transient Elastography (TE). Two individual investigators performed all measurements non-continued and in parallel. The methods were evaluated for inter- and intraobserver variability by intraclass correlation, coefficient of variation and limits of agreement using the median elastography value. All systems used in this study provided high repeatability in quantitative measurements in a liver fibrosis phantom and excellent inter- and intraclass correlations. All four elastography platforms showed excellent intra-and interobserver agreement (interclass correlation 0.981-1.000 and intraclass correlation 0.987-1.000) and no significant difference in mean elasticity measurements for all systems, except for TE on phantom 4. All four liver fibrosis phantoms could be differentiated by quantitative elastography, by all platforms (p<0.001). In the Bland-Altman analysis the differences in measurements were larger for the phantoms with higher Young's modulus. All platforms had a coefficient of variation in the range 0.00-0.21 for all four phantoms, equivalent to low variance and high repeatability.
[Mh] Termos MeSH primário: Técnicas de Imagem por Elasticidade/métodos
Cirrose Hepática/diagnóstico por imagem
Imagens de Fantasmas
[Mh] Termos MeSH secundário: Seres Humanos
Variações Dependentes do Observador
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189671


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[PMID]:29419681
[Au] Autor:Park GY; Kwon DR; Kwon DG
[Ad] Endereço:Department of Rehabilitation Medicine, Catholic University of Daegu School of Medicine, Daegu, South Korea.
[Ti] Título:Shear wave sonoelastography in infants with congenital muscular torticollis.
[So] Source:Medicine (Baltimore);97(6):e9818, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Congenital muscular torticollis (CMT) is characterized by shortening or excessive contraction of the sternocleidomastoid muscle (SCM). The main purpose of this study was to evaluate the feasibility of quantifying SCM stiffness using acoustic radiation force impulse (ARFI) sonoelastography in infants with CMT. Twenty infants with an SCM thickness greater than 10 mm with or without involvement of the entire SCM length (limitation of neck rotation passive range of motion [PROM]: group 1S >30°, group 1M = 15°-30°) and 12 infants with an SCM thickness smaller than 10 mm with or without involvement of any part of SCM (group 2) were included. The SCM thickness was measured using real time B-mode ultrasound, and the local SCM shear wave velocity (SWV) and subcutaneous fat layer using ARFI sonoelastography. The neck rotation PROM was significantly greater in group 1S (36.5°â€Š±â€Š5.3°) than in group 1M (18.8°â€Š±â€Š4.9°; P < .01); the SWV of the SCM in the affected side (2.96 ±â€Š0.99 m/s) was significantly higher than that in the unaffected side (1.50 ±â€Š0.30 m/s; P < .01) in group 1. The SWV of the SCM was significantly higher in group 1S than in group 1M. There was significant correlation between the degree of PROM deficit of neck rotation and the SWV of the affected SCM (r = .75; P < .01) in all infants. This study revealed a difference in the SWV of the affected SCM in relationship to the limitation of neck rotation PROM in infants with CMT, if there was no difference in SCM thickness among infants.
[Mh] Termos MeSH primário: Técnicas de Imagem por Elasticidade/métodos
Músculos do Pescoço
Torcicolo/congênito
[Mh] Termos MeSH secundário: Estudos Transversais
Elasticidade/fisiologia
Feminino
Seres Humanos
Lactente
Masculino
Contração Muscular/fisiologia
Músculos do Pescoço/diagnóstico por imagem
Músculos do Pescoço/fisiopatologia
Amplitude de Movimento Articular
República da Coreia
Estatística como Assunto
Torcicolo/diagnóstico
Torcicolo/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180209
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009818


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[PMID]:29390418
[Au] Autor:You M; Zhang L; Fang L; Li J; Xie M
[Ad] Endereço:Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology.
[Ti] Título:Evaluation of carotid arterial elasticity in patients with obstructive sleep apnea hypopnea syndrome by two-dimensional speckle tracking imaging.
[So] Source:Medicine (Baltimore);96(51):e8817, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The objective is to evaluate carotid arterial elasticity in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) by two-dimensional speckle tracking imaging (2D-STI).Sixty-two hospitalized patients with OSAHS and 20 healthy subjects were studied. The OSAHS patients were divided into 3 subgroups: a mild group, a moderate group, and severe group. All subjects underwent complete left common carotid artery (LCCA) examination by echo-tacking technique and 2D-STI. The stiffness parameter (ß), elastic modulus (Eρ), stiffness ß single pulse wave velocity (PWVß), and arterial compliance (AC) were automatically calculated by echo-tracking technique. And the global and segmental peak systolic circumferential artery strain (CAS) values were made off-line using 2D-STI.The ß, Ep, and PWVß values of the carotid artery in the moderate and severe groups were greater than those in the control group (P < .05). In addition, the systolic peak global CAS and the segments between 5 and 7 o'clock in the moderate and severe groups were lower than those in the control group (P < .05). Compared with mild group, the ß, PWVp, and Ep values of the carotid artery in the moderate and severe groups were higher (P < .05) and the systolic peak global CAS lower than in the control group (P < .05). The systolic peak global CAS was significantly inversely correlated with stiffness (ß, r = - 0.61, P < .05) and stiffness ß single pulse wave velocity (PWVß, r = -0.59, P < .05). Through stepwise multiple linear regression analysis, age and SaO2 were the significant variables that determined the systolic peak global CAS2D-STI provides a new method to investigate carotid arterial elasticity in patients with OSAHS.
[Mh] Termos MeSH primário: Artéria Carótida Primitiva/fisiopatologia
Síndromes da Apneia do Sono/fisiopatologia
Apneia Obstrutiva do Sono/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Técnicas de Imagem por Elasticidade
Feminino
Seres Humanos
Interpretação de Imagem Assistida por Computador
Masculino
Meia-Idade
Análise de Onda de Pulso
Sensibilidade e Especificidade
Síndromes da Apneia do Sono/complicações
Apneia Obstrutiva do Sono/complicações
Síndrome
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008817


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[PMID]:28470104
[Au] Autor:Belanger AR; Akulian JA
[Ad] Endereço:Division of Pulmonary and Critical Care, Section of Interventional Pulmonology, University of North Carolina at Chapel Hill, NC, USA.
[Ti] Título:An update on the role of advanced diagnostic bronchoscopy in the evaluation and staging of lung cancer.
[So] Source:Ther Adv Respir Dis;11(5):211-221, 2017 05.
[Is] ISSN:1753-4666
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Lung cancer remains a common and deadly disease. Many modalities are available to the bronchoscopist to evaluate and stage lung cancer. We review the role of bronchoscopy in the staging of the mediastinum with convex endobronchial ultrasound (EBUS) and discuss emerging role of esophageal ultrasonography as a complementary modality. In addition, we discuss advances in scope technology and elastography. We review the bronchoscopic methods available for the diagnosis of peripheral lung nodules including radial EBUS and navigational bronchoscopy (NB) with a consideration of the basic methodologies and diagnostic accuracies. We conclude with a discussion of the comparison of the various methodologies.
[Mh] Termos MeSH primário: Broncoscopia/métodos
Endossonografia/métodos
Neoplasias Pulmonares/diagnóstico
[Mh] Termos MeSH secundário: Técnicas de Imagem por Elasticidade/métodos
Seres Humanos
Neoplasias Pulmonares/patologia
Mediastino
Estadiamento de Neoplasias
Nódulo Pulmonar Solitário/diagnóstico
Nódulo Pulmonar Solitário/patologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180110
[Lr] Data última revisão:
180110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1177/1753465817695981


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[PMID]:29188950
[Au] Autor:Collin P; Mäkelä T
[Ti] Título:Diagnosis for liver fibrosis - noninvasively.
[So] Source:Duodecim;132(18):1714-8, 2016.
[Is] ISSN:0012-7183
[Cp] País de publicação:Finland
[La] Idioma:eng
[Ab] Resumo:Noninvasive tests are utilized in chronic liver diseases to assess excessive connective tissue. Blood tests such as the N-terminal peptide of procollagen (PIIINP) and APRI (ASAT/platelet count) measure the formation and degradation of connective tissue or liver function. Elastography (Fibroscan) is based on the propagation of ultrasound in liver tissue, accelerated by fibrosis: the results are more sensitive and accurate than those based on blood tests. Reliable detection of severe fibrosis and cirrhosis is possible with Fibroscan along with determining normal liver tissue.
[Mh] Termos MeSH primário: Biomarcadores/sangue
Técnicas de Imagem por Elasticidade
Cirrose Hepática/sangue
Cirrose Hepática/diagnóstico por imagem
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE


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[PMID]:29212007
[Au] Autor:Wijesinghe P; Johansen NJ; Curatolo A; Sampson DD; Ganss R; Kennedy BF
[Ad] Endereço:BRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands and Centre for Medical Research, The University of Western Australia, Perth, Western Australia, Australia; Optical+Biomedical Engineering Laboratory, School of Electrical, Electronic and Computer Engineering, The Un
[Ti] Título:Ultrahigh-Resolution Optical Coherence Elastography Images Cellular-Scale Stiffness of Mouse Aorta.
[So] Source:Biophys J;113(11):2540-2551, 2017 Dec 05.
[Is] ISSN:1542-0086
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cellular-scale imaging of the mechanical properties of tissue has helped to reveal the origins of disease; however, cellular-scale resolution is not readily achievable in intact tissue volumes. Here, we demonstrate volumetric imaging of Young's modulus using ultrahigh-resolution optical coherence elastography, and apply it to characterizing the stiffness of mouse aortas. We achieve isotropic resolution of better than 15 µm over a 1-mm lateral field of view through the entire depth of an intact aortic wall. We employ a method of quasi-static compression elastography that measures volumetric axial strain and uses a compliant, transparent layer to measure surface axial stress. This combination is used to estimate Young's modulus throughout the volume. We demonstrate differentiation by stiffness of individual elastic lamellae and vascular smooth muscle. We observe stiffening of the aorta in regulator of G protein signaling 5-deficient mice, a model that is linked to vascular remodeling and fibrosis. We observe increased stiffness with proximity to the heart, as well as regions with micro-structural and micro-mechanical signatures characteristic of fibrous and lipid-rich tissue. High-resolution imaging of Young's modulus with optical coherence elastography may become an important tool in vascular biology and in other fields concerned with understanding the role of mechanics within the complex three-dimensional architecture of tissue.
[Mh] Termos MeSH primário: Aorta/diagnóstico por imagem
Aorta/fisiologia
Técnicas de Imagem por Elasticidade
Fenômenos Ópticos
Razão Sinal-Ruído
Rigidez Vascular
[Mh] Termos MeSH secundário: Animais
Aorta/metabolismo
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Proteínas RGS/deficiência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RGS Proteins); 0 (Rgs5 protein, mouse)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180103
[Lr] Data última revisão:
180103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE



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