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[PMID]:28454690
[Au] Autor:Spiel M; Salahuddin S; Pernicone E; Zsengeller Z; Wang A; Modest AM; Karumanchi SA; Hecht JL
[Ad] Endereço:Department of Obstetrics & Gynecology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA.
[Ti] Título:Placental soluble fms-like tyrosine kinase expression in small for gestational age infants and risk for adverse outcomes.
[So] Source:Placenta;52:10-16, 2017 Apr.
[Is] ISSN:1532-3102
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Soluble fms-like tyrosine kinase 1 (sFLT-1) is an anti-angiogenic factor implicated in the pathogenesis of preterm preeclampsia. We evaluated sFLT-1 expression and placental pathology in pregnancies complicated by small for gestational age (SGA) infants (<10th percentile), without evidence of preeclampsia. METHODS: Clinical and histologic data were compared between groups with high or low sFLT-1 expression determined by immunohistochemistry on archived placentas. RESULTS: Nineteen of 69 placentas showed high sFLT-1 expression. The high sFLT-1 group had higher predelivery median systolic blood pressure (BP); 140 (interquartile range (IQR) 133-152) vs. 126 (118-139) mm Hg (p = 0.003), and median diastolic BP; 87 (78-94) vs. 77.5 (71-86) mm Hg (p = 0.02). Abnormal umbilical Doppler abnormalities were more prevalent; 89.5% vs. 46% (p = 0.001). These pregnancies delivered earlier; 31.9 weeks (28.3-34.7 weeks) vs. 37.1 weeks (33.7-38.7 weeks) (p < 0.001), and infants had lower birthweight; 980 grams (520-1545 grams) vs. 2087.5 grams (1455-2340 grams) (p < 0.001). Placental-weight to fetal-weight ratios, a marker of vascular insufficiency, was increased in the high sFlt-1 group: 0.18 (0.14-0.28) vs 0.15 (0.13-0.18), p = 0.03. Placentas with high sFLT-1 showed more decidual vasculopathy; 42.1% vs. 10.0% (p = 0.005), infarction; 36.8% vs. 14.0% (p = 0.048), distal villous hypoplasia; 78.9% vs. 36.0% (p = 0.001), and fetal thrombotic vasculopathy; 47.4% vs. 16.0% (p = 0.01). DISCUSSION: Placental sFLT-1 expression is upregulated in approximately 28% of non-preeclamptic pregnancies complicated by SGA infants. These pregnancies showed increased placental vascular pathology, more umbilical Doppler abnormalities, and earlier delivery with lower birthweight. A subgroup of non-preeclamptic fetal growth restriction with upregulated sFlt-1 expression may share a common pathogenic pathway with preterm preeclampsia. This subgroup is worthy of additional study.
[Mh] Termos MeSH primário: Recém-Nascido Pequeno para a Idade Gestacional/metabolismo
Placenta/metabolismo
Insuficiência Placentária/metabolismo
Regulação para Cima
Receptor 1 de Fatores de Crescimento do Endotélio Vascular/metabolismo
[Mh] Termos MeSH secundário: Adulto
Feminino
Idade Gestacional
Seres Humanos
Recém-Nascido
Placenta/diagnóstico por imagem
Placenta/patologia
Insuficiência Placentária/diagnóstico por imagem
Insuficiência Placentária/patologia
Gravidez
Ultrassonografia Doppler
Ultrassonografia Pré-Natal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-1)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


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[PMID]:29390303
[Au] Autor:Cho SB; Choi HC; Bae E; Park TJ; Baek HJ; Park SE; Ryu KH; Moon JI; Choi BH; Bae K; Jeon KN
[Ad] Endereço:Department of Radiology, Gyeongsang National University School of Medicine, Gyeongsang National University Changwon Hospital, Seongsan-gu, Changwon.
[Ti] Título:Angioplasty and stenting for the proximal anastomotic stenosis of a brachio-axillary bypass graft using a helical interwoven nitinol stent: A case report.
[So] Source:Medicine (Baltimore);96(50):e9073, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Thrombosis due to anastomotic site stenosis is the most common complication in patients with brachio-axillary arteriovenous graft (AVG). Intravascular stent placement may play a special role in the salvage of dialysis grafts that have been previously performed percutaneous angioplasty or surgical procedure on the graft. Herein, we applied a novel stent named Supera which has a high degree of flexibility and resistance to external compression for treating a patient with recurrent venous anastomotic stenosis of brachio-axillary AVG. PATIENTS CONCERNS AND DIAGNOSES: We report a case of the patient with end-stage renal disease who presented with brachio-axillary AVG malfunction. INTERVENTIONS: The patient underwent repeated percutaneous angioplasty with thrombectomy for total graft occlusion, and we placed the Supera stent to salvage the graft. OUTCOMES: Postprocedural Doppler ultrasonography did not show any restenosis on the 1- and 3-month follow-up periods, and average flow volume in the stent was >1000 mL/min. And he has been on dialysis for 6 months without any problems after stent placement. LESSONS: The Supera stent is a useful treatment option of interventional procedure for recurrent venous anastomotic stenosis of brachio-axillary AVG in the clinical practice.
[Mh] Termos MeSH primário: Angioplastia/métodos
Derivação Arteriovenosa Cirúrgica
Oclusão de Enxerto Vascular/cirurgia
Stents
[Mh] Termos MeSH secundário: Idoso
Ligas
Veia Axilar
Artéria Braquial
Oclusão de Enxerto Vascular/diagnóstico por imagem
Seres Humanos
Falência Renal Crônica/terapia
Masculino
Diálise Renal
Trombectomia
Ultrassonografia Doppler
Grau de Desobstrução Vascular
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alloys); 2EWL73IJ7F (nitinol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009073


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[PMID]:28468953
[Au] Autor:Randhawa MS; Reed GW; Grafmiller K; Gornik HL; Shishehbor MH
[Ad] Endereço:From the Department of Cardiovascular Medicine, Cleveland Clinic, OH; and School of Medicine, Case Western Reserve University, Cleveland, OH.
[Ti] Título:Prevalence of Tibial Artery and Pedal Arch Patency by Angiography in Patients With Critical Limb Ischemia and Noncompressible Ankle Brachial Index.
[So] Source:Circ Cardiovasc Interv;10(5), 2017 May.
[Is] ISSN:1941-7632
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Approximately 20% of patients undergoing ankle brachial index testing for critical limb ischemia have noncompressible vessels because of tibial artery calcification. This represents a clinical challenge in determining tibial artery patency. We sought to identify the prevalence of tibial artery and pedal arch patency by angiography in these patients. METHODS AND RESULTS: One hundred twenty-five limbs (of 89 patients) with critical limb ischemia and ankle brachial index ≥1.4 who underwent lower extremity angiograms within 1 year were included. Reviewers of angiography were blinded to results of physiological testing. Tibial artery vessels were classified as completely occluded, significantly stenosed (≥50%), or patent (<50% stenosis). The sensitivity of toe brachial index and pulse volume recording to predict tibial artery disease was also determined. Of 125 limbs with noncompressible ankle brachial index, 72 (57.6%) anterior tibial and 80 (64%) posterior tibial arteries were occluded. Another 23 (18.4%) anterior tibial and 13 (10.4%) posterior tibial arteries had ≥50% stenosis. Pulse volume recording was moderate to severely dampened in 54 of 119 (45.4%) limbs. Toe brachial index <0.7 was found in 75 of 83 (90.4%) limbs. Moderate to severe pulse volume recording dampening was 43.6% sensitive, whereas toe brachial index <0.7 was 89.7% sensitive in diagnosing occluded or significantly stenotic tibial artery disease. The pedal arch was absent or incomplete in 86 of 103 (83.5%) limbs. CONCLUSIONS: Among patients with critical limb ischemia and noncompressible ankle brachial index results, the prevalence of occlusive tibial and pedal arch disease is very high. Toe brachial index <0.7 is more sensitive in diagnosing occluded and significantly stenotic tibial artery disease in these patients compared with ankle pulse volume recording.
[Mh] Termos MeSH primário: Angiografia
Índice Tornozelo-Braço
Isquemia/diagnóstico
Doença Arterial Periférica/diagnóstico
Artérias da Tíbia/diagnóstico por imagem
Calcificação Vascular/diagnóstico
Grau de Desobstrução Vascular
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Constrição Patológica
Estado Terminal
Feminino
Seres Humanos
Isquemia/diagnóstico por imagem
Isquemia/epidemiologia
Isquemia/fisiopatologia
Masculino
Meia-Idade
Ohio/epidemiologia
Doença Arterial Periférica/diagnóstico por imagem
Doença Arterial Periférica/epidemiologia
Doença Arterial Periférica/fisiopatologia
Valor Preditivo dos Testes
Prevalência
Estudos Retrospectivos
Índice de Gravidade de Doença
Artérias da Tíbia/fisiopatologia
Ultrassonografia Doppler
Calcificação Vascular/diagnóstico por imagem
Calcificação Vascular/epidemiologia
Calcificação Vascular/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE


  4 / 13720 MEDLINE  
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[PMID]:28463190
[Au] Autor:Tremblay-Darveau C; Bar-Zion A; Williams R; Sheeran PS; Milot L; Loupas T; Adam D; Bruce M; Burns PN
[Ti] Título:Improved Contrast-Enhanced Power Doppler Using a Coherence-Based Estimator.
[So] Source:IEEE Trans Med Imaging;36(9):1901-1911, 2017 09.
[Is] ISSN:1558-254X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:While plane-wave imaging can improve the performance of power Doppler by enabling much longer ensembles than systems using focused beams, the long-ensemble averaging of the zero-lag autocorrelation R(0) estimates does not directly decrease the mean noise level, but only decreases its variance. Spatial variation of the noise due to the time-gain compensation and the received beamforming aperture ultimately limits sensitivity. In this paper, we demonstrate that the performance of power Doppler imaging can be improved by leveraging the higher lags of the autocorrelation [e.g., R(1), R(2),…] instead of the signal power (R(0)). As noise is completely uncorrelated from pulse-to-pulse while the flow signal remains correlated significantly longer, weak signals just above the noise floor can be made visible through the reduction of the noise floor. Finally, as coherence decreases proportionally with respect to velocity, we demonstrate how signal coherence can be targeted to separate flows of different velocities. For instance, we show how long-time-range coherence of microbubble contrast-enhanced flow specifically isolates slow capillary perfusion (as opposed to conduit flow).
[Mh] Termos MeSH primário: Ultrassonografia Doppler
[Mh] Termos MeSH secundário: Velocidade do Fluxo Sanguíneo
Microbolhas
Imagens de Fantasmas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1109/TMI.2017.2699672


  5 / 13720 MEDLINE  
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[PMID]:28457427
[Au] Autor:Chong AY; Doyle BJ; Jansen S; Ponosh S; Cisonni J; Sun Z
[Ad] Endereço:Department of Medical Radiation Sciences, Curtin University, Perth, Australia.
[Ti] Título:Blood flow velocity prediction in aorto-iliac stent grafts using computational fluid dynamics and Taguchi method.
[So] Source:Comput Biol Med;84:235-246, 2017 May 01.
[Is] ISSN:1879-0534
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Covered Endovascular Reconstruction of Aortic Bifurcation (CERAB) is a new technique to treat extensive aortoiliac occlusive disease with covered expandable stent grafts to rebuild the aortoiliac bifurcation. Post stenting Doppler ultrasound (DUS) measurement of maximum peak systolic velocity (PSV ) in the stented segment is widely used to determine patency and for follow up surveillance due to the portability, affordability and ease of use. Anecdotally, changes in hemodynamics created by CERAB can lead to falsely high PSV requiring CT angiography (CTA) for further assessment. Therefore, the importance of DUS would be enhanced with a proposed PSV prediction tool to ascertain whether PSV falls within the acceptable range of prediction. We have developed a prediction tool based on idealized models of aortoiliac bifurcations with various infra-renal PSV (PSV ), iliac to aortic area ratios (R) and aortoiliac bifurcation angles (α). Taguchi method with orthogonal arrays (OA) was utilized to minimize the number of Computational Fluid Dynamics (CFD) simulations performed under physiologically realistic conditions. Analysis of Variance (ANOVA) and Multiple Linear Regression (MLR) analyses were performed to assess Goodness of fit and to predict PSV PSV and R were found to contribute 94.06% and 3.36% respectively to PSV . The Goodness of fit based on adjusted R improved from 99.1% to 99.9% based on linear and exponential functions. The PSV predictor based on the exponential model was evaluated with sixteen patient specific cases with a mean prediction error of 9.9% and standard deviation of 6.4%. Eleven out of sixteen cases (69%) in our current retrospective studies would have avoided CTA if the proposed predictor was used to screen out DUS measured PSV with prediction error greater than 15%. The predictor therefore has the potential to be used as a clinical tool to detect PSV more accurately post aortoiliac stenting and might reduce diagnostic errors and avoid unnecessary expense and risk from CTA follow-up imaging.
[Mh] Termos MeSH primário: Aorta Abdominal
Velocidade do Fluxo Sanguíneo/fisiologia
Artéria Ilíaca
Processamento de Imagem Assistida por Computador/métodos
Stents
[Mh] Termos MeSH secundário: Aorta Abdominal/diagnóstico por imagem
Aorta Abdominal/fisiologia
Aorta Abdominal/cirurgia
Implante de Prótese Vascular
Seres Humanos
Artéria Ilíaca/diagnóstico por imagem
Artéria Ilíaca/fisiologia
Artéria Ilíaca/cirurgia
Modelos Estatísticos
Sístole/fisiologia
Ultrassonografia Doppler
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


  6 / 13720 MEDLINE  
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[PMID]:29390476
[Au] Autor:Sun W; Liu MN; Yang ZW; Wang Q; Xu Y
[Ad] Endereço:Department of Ultrasound, Daqing Oilfield General Hospital, Daqing, China.
[Ti] Título:Ultrasound-guided percutaneous nephrolithotomy for the treatment in patients with kidney stones.
[So] Source:Medicine (Baltimore);96(51):e9232, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In this study, we aimed to explore the effect of ultrasound-guided percutaneous nephrolithotomy (UGPN) for the treatment in patients with kidney stones (KS). METHODS: We randomly assigned 86 patients with KS to a UGPN group or a control group, each group comprising 43 patients. Patients from the UGPN group underwent UGPN whereas those from control group underwent fluoroscopic-guided percutaneous nephrolithotomy (FGPN). The primary outcome included the stone-free rate. Secondary outcomes included complication rates, operative time, and length of hospitalization. RESULTS: UGPN did not show better efficacy than the FGPN procedure in decreasing stone-free rate (UGPN group 79.1% vs control group 69.8%, P = .45), operative time (UGPN group 108.4 ±â€Š31.7 minute vs control group 113.2 ±â€Š34.5 minute, P = .50), and length of hospitalization (UGPN group 2.7 ±â€Š1.3 days vs control group 3.1 ±â€Š1.5 days, P = .19). Additionally, no complications, except fever (UGPN group 4.7% vs control group 9.3%, P = .41) and hemoglobin slightly reduced (UGPN group 7.0% vs control group 11.6%, P = .46) were noted in patients from both groups in this study. CONCLUSIONS: To summarize, we demonstrated that both UGPN and FGPN techniques showed similar efficacy and complications when used for the management of KS.
[Mh] Termos MeSH primário: Cálculos Renais/diagnóstico por imagem
Cálculos Renais/cirurgia
Nefrolitotomia Percutânea/métodos
Ultrassonografia Doppler/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Distribuição de Qui-Quadrado
China
Fluoroscopia
Seguimentos
Hospitais Universitários
Seres Humanos
Masculino
Meia-Idade
Procedimentos Cirúrgicos Minimamente Invasivos/métodos
Valores de Referência
Medição de Risco
Índice de Gravidade de Doença
Estatísticas não Paramétricas
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009232


  7 / 13720 MEDLINE  
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[PMID]:27775821
[Au] Autor:Atiq O; Tiro J; Yopp AC; Muffler A; Marrero JA; Parikh ND; Murphy C; McCallister K; Singal AG
[Ad] Endereço:Department of Internal Medicine, UT Southwestern Medical Center and Parkland Health Hospital System, Dallas, TX.
[Ti] Título:An assessment of benefits and harms of hepatocellular carcinoma surveillance in patients with cirrhosis.
[So] Source:Hepatology;65(4):1196-1205, 2017 04.
[Is] ISSN:1527-3350
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Although surveillance ultrasound and alpha fetoprotein (AFP) tests have minimal direct harm, downstream harms from follow-up tests must be weighed against surveillance benefits when determining the value of hepatocellular carcinoma (HCC) screening programs. Our study's aims were to characterize prevalence and correlates of surveillance benefits and harms in cirrhosis patients undergoing HCC surveillance. We conducted a retrospective cohort study among patients with cirrhosis followed at a safety-net health system between July 2010 and July 2013. We recorded surveillance-related benefits, defined as early tumor detection and curative treatment, and surveillance-related physical harms, defined as computed tomography or magnetic resonance imaging scans, biopsies, or other procedures performed for false-positive or indeterminate surveillance results. Sociodemographic and clinical correlates of surveillance harms were evaluated using multivariable logistic regression. We identified 680 patients with cirrhosis, of whom 78 (11.5%) developed HCC during the 3-year study period. Of the 48 (61.5%) HCCs identified by surveillance, 43.8% were detected by ultrasound, 31.2% by AFP, and 25.0% by both surveillance tests. Surveillance-detected patients had a higher proportion of early HCC (70.2% vs. 40.0%; P = 0.009), with no difference in tumor stage between ultrasound- and AFP-detected tumors (P = 0.53). Surveillance-related physical harms were observed in 187 (27.5%) patients, with a higher proportion of ultrasound-related harm than AFP-related harm (22.8% vs. 11.4%; P < 0.001). Surveillance-related harms were associated with elevated ALT (odds ratio [OR], 1.87; 95% confidence interval [CI], 1.26-2.76), thrombocytopenia (OR, 2.06; 95% CI, 1.26-3.38), and hepatology subspecialty care (OR, 1.63; 95% CI, 1.09-2.42). CONCLUSION: Over one fourth of patients with cirrhosis experience physical harm for false-positive or indeterminate surveillance tests-more often related to ultrasound than AFP. Interventions are needed to reduce surveillance-related harm to increase the value of HCC screening programs in clinical practice. (Hepatology 2017;65:1196-1205).
[Mh] Termos MeSH primário: Carcinoma Hepatocelular/diagnóstico
Detecção Precoce de Câncer/métodos
Cirrose Hepática/diagnóstico
Neoplasias Hepáticas/diagnóstico
Ultrassonografia Doppler
alfa-Fetoproteínas/metabolismo
[Mh] Termos MeSH secundário: Adulto
Transformação Celular Neoplásica
Estudos de Coortes
Feminino
Seres Humanos
Testes de Função Hepática
Masculino
Programas de Rastreamento/métodos
Meia-Idade
Análise Multivariada
Razão de Chances
Prognóstico
Estudos Retrospectivos
Medição de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (alpha-Fetoproteins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1002/hep.28895


  8 / 13720 MEDLINE  
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[PMID]:29215516
[Au] Autor:Jones T; Ho JR; Gualtieri M; Bruno-Gaston J; Chung K; Paulson RJ; Bendikson KA
[Ad] Endereço:Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, California.
[Ti] Título:Clomiphene Stair-Step Protocol for Women With Polycystic Ovary Syndrome.
[So] Source:Obstet Gynecol;131(1):91-95, 2018 Jan.
[Is] ISSN:1873-233X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To compare time to ovulation, ovulation rates, and side effect profile of traditional and the stair-step protocol for ovulation induction using clomiphene citrate in women with polycystic ovary syndrome (PCOS). METHODS: We performed a retrospective study of women seeking care for infertility with a diagnosis of PCOS at a university-based infertility clinic from July 2012 to July 2014. We included patients who were resistant to the initial starting dose of 50 mg clomiphene. The primary outcome was time to ovulation. Secondary outcomes included ovulation rates, clinical pregnancy rates, and mild and moderate-to-severe side effects based on dose. For the traditional protocol, higher doses of clomiphene were used each subsequent month if no ovulation occurred. For the stair-step protocol, higher doses of clomiphene were given 7 days after the last dose if no dominant follicles were seen on ultrasonography. Our study had 80% power to detect a 20% difference in ovulation. RESULTS: One hundred nine patients were included in the analysis with 66 (60.6%) in the traditional and 43 (39.4%) in the stair-step protocol. Age and body mass index were similar between groups. The time to ovulation was decreased in the stair-step protocol group compared with the traditional protocol group (23.1±0.9 days vs 47.5±6.3 days). Ovulation rates were increased in the stair-step group compared with the traditional group at 150 mg (16 [37%] vs 8 [12%], P=.004) and at 200 mg (9 [21%] vs 3 [5%], P=.01). Pregnancy rates were similar between groups once ovulation was achieved (12 [18.1%] vs 7 [16.3%], P=.08). The stair-step protocol had an increased incidence of mild side effects (vasomotor flushes, headaches, gastrointestinal disturbance, mastalgia, changes in mood; 18 [41%] vs 8 [12%]), but there was no difference in the incidence of severe side effects (headaches, visual disturbances). CONCLUSION: For women with PCOS, the stair-step clomiphene protocol is associated with decreased time to ovulation and increased ovulation rates at higher doses when compared with the traditional protocol.
[Mh] Termos MeSH primário: Clomifeno/administração & dosagem
Fármacos para a Fertilidade/administração & dosagem
Indução da Ovulação/métodos
Síndrome do Ovário Policístico/tratamento farmacológico
Taxa de Gravidez
[Mh] Termos MeSH secundário: Adulto
Análise de Variância
Clomifeno/efeitos adversos
Estudos de Coortes
Relação Dose-Resposta a Droga
Esquema de Medicação
Feminino
Fármacos para a Fertilidade/efeitos adversos
Seguimentos
Hospitais Universitários
Seres Humanos
Ovulação/efeitos dos fármacos
Síndrome do Ovário Policístico/diagnóstico por imagem
Gravidez
Estudos Retrospectivos
Medição de Risco
Estatísticas não Paramétricas
Fatores de Tempo
Resultado do Tratamento
Ultrassonografia Doppler/métodos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fertility Agents); 1HRS458QU2 (Clomiphene)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1097/AOG.0000000000002418


  9 / 13720 MEDLINE  
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[PMID]:29190041
[Au] Autor:Koski J
[Ti] Título:Doppler imaging in inflammatory rheumatic diseases.
[So] Source:Duodecim;132(20):1882-9, 2016.
[Is] ISSN:0012-7183
[Cp] País de publicação:Finland
[La] Idioma:eng
[Ab] Resumo:Doppler imaging has increased in rheumatology during this millennium. The method can detect slow blood flow in inflamed synovium and soft tissues. Doppler imaging is more sensitive than clinical examination in the detection of joint inflammation. Ultrasound imaging combined with Doppler imaging is regarded as reference method in the evaluation of enthesitis,. Doppler imaging is an excellent tool in the diagnostics and follow up in the treatment of the inflammatory rheumatic diseases because it does not use radiation, can be performed bedside and repeated often. The adjustment of ultrasound and Doppler signal is machine specific.
[Mh] Termos MeSH primário: Doenças Reumáticas/diagnóstico por imagem
Ultrassonografia Doppler
[Mh] Termos MeSH secundário: Seres Humanos
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE


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[PMID]:28471025
[Au] Autor:Demers S; Roberge S; Bujold E
[Ad] Endereço:Department of Obstetrics and Gynecology, Faculty of Medicine, Université Laval, 2705 Boulevard Laurier, Québec, QC, G1V 4G2, Canada.
[Ti] Título:Re: Impact of aspirin on trophoblastic invasion in women with abnormal uterine artery Doppler at 11-14 weeks.
[So] Source:Ultrasound Obstet Gynecol;49(5):664-665, 2017 05.
[Is] ISSN:1469-0705
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Aspirina
Artéria Uterina
[Mh] Termos MeSH secundário: Artérias
Feminino
Seres Humanos
Pré-Eclâmpsia
Trofoblastos
Ultrassonografia Doppler
Ultrassonografia Pré-Natal
Útero/irrigação sanguínea
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
R16CO5Y76E (Aspirin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1002/uog.17450



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