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[PMID]: 29282046 [Au] Autor: Ranasinghe P; Jayawardena R; Pigera S; Wathurapatha WS; Weeratunga HD; Premakumara GAS; Katulanda P; Constantine GR; Galappaththy P [Ad] Endereço: Department of Pharmacology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. priyanga.ranasinghe@gmail.com. [Ti] Título: Evaluation of pharmacodynamic properties and safety of Cinnamomum zeylanicum (Ceylon cinnamon) in healthy adults: a phase I clinical trial. [So] Source: BMC Complement Altern Med;17(1):550, 2017 Dec 28. [Is] ISSN: 1472-6882 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: Cinnamon is considered as a treatment for many ailments in native medicine. Evidence suggests that Cinnamomum zeylanicum (CZ) has anti-microbial, anti-parasitic, anti-oxidant, blood glucose lowering properties and beneficial cardiovascular effects. The present study aims to evaluate Pharmacodynamic properties and safety of CZ in healthy adults using a Phase I Clinical Trial. METHODS: This phase I clinical trial was conducted at the Department of Pharmacology, Faculty of Medicine, University of Colombo, Sri Lanka. Thirty healthy adults were recruited for the study, conducted for a period of 3 months, with the dose of CZ (water extract) increased at monthly intervals (85 mg, 250 mg and 500 mg). Data collection was carried out at baseline and during each monthly follow up visit. Anthropometric, clinical and biochemical assessments were done at baseline and during follow up. Adverse effects and drug compliance was also evaluated. RESULTS: Twenty eight subjects completed the three months follow up. Mean age was 38.8 ± 10.4 years and 50% were males. There were no significant changes in the anthropometric parameters during the three months follow up. Both systolic and diastolic blood pressure reduced significant during the 1st month and this reduction was sustained throughout follow up. Full blood count, renal function tests, liver function tests, fasting blood glucose, HDL-c, VLDL-d and triglycerides remained within the normal range without any significant alteration during the 3 months. A significant reduction in the TC (p < 0.05) and LDL-c (p < 0.001) was noted at the end of the 3 months follow up period. There were no serious adverse effects (including hypersensitivity) noted. In two participants dyspepsia necessitated the discontinuation of study participation. Drug compliance was between 85 and 95% during the study period. CONCLUSIONS: This is the first phase I clinical trial in health adults evaluating efficacy and safety of CZ. Our results demonstrate no significant side effects and toxicity of CZ, including hepatotoxicity and anti-coagulation properties. CZ demonstrated beneficial anti-hyperlipidaemic and blood pressure lowering effects among healthy adults. Further studies with larger samples and longer durations may be able to elucidate other side effects and better describe the pharmacodynamic properties. TRIAL REGISTRATION: SLCTR/2013/001 (Sri Lanka Clinical Trials Registry: http://www.slctr.lk/trials/106 ) (Date of Registration: 01/01/2013). [Mh] Termos MeSH primário: Cinnamomum zeylanicum Extratos Vegetais/efeitos adversos Extratos Vegetais/farmacologia [Mh] Termos MeSH secundário: Adulto Pressão Sanguínea/efeitos dos fármacos Peso Corporal/efeitos dos fármacos Feminino Seres Humanos Masculino Meia-Idade Pulso Arterial Sri Lanka Adulto Jovem [Pt] Tipo de publicação: CLINICAL TRIAL, PHASE I; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Plant Extracts) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180122 [Lr] Data última revisão: 180122 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171229 [St] Status: MEDLINE [do] DOI: 10.1186/s12906-017-2067-7

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[PMID]: 28953635 [Au] Autor: Zhang W; Danzeng Q; Feng X; Cao X; Chen W; Kang Y [Ad] Endereço: aDepartment of Critical Care Medicine, Sichuan University West China Hospital, Chengdu, Sichuan bDepartment of Critical Care Medicine, Affiliated Hospital of Zunyi Medical College cDepartment of Critical Care Medicine, First People's Hospital of Zunyi, Zunyi, Guizhou, China. [Ti] Título: Sequential Organ Failure Assessment predicts outcomes of pulse indicator contour continuous cardiac output-directed goal therapy: A prospective study. [So] Source: Medicine (Baltimore);96(39):e8111, 2017 Sep. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: According to the new sepsis definitions, septic shock is defined as a subset of sepsis in which the underlying circulatory and cellular/metabolic abnormalities are profound enough to substantially increase mortality. We evaluated the predictive efficacy of the Sequential Organ Failure Assessment (SOFA) score in critically ill patients with septic shock undergoing pulse indicator contour continuous cardiac output (PiCCO)-directed goal therapy (PDGT).We conducted a single-center, prospective, observational study of 52 patients with septic shock undergoing PDGT. The putative prognostic factors, including the severity scores (SOFA and Acute Physiology and Chronic Health Evaluation II [APACHE II] scores), were analyzed within 24 hours after diagnosis of septic shock. We assessed and compared the predictive efficacy of risk factors for 28-day mortality of patients with septic shock undergoing PDGT.Among the patients with septic shock undergoing PDGT, the SOFA scores of nonsurvivors were significantly higher than those of survivors (P < .001); the area under the receiver operating characteristics curve was higher for SOFA than for APACHE II (P = .005). The outcomes of the logistic regression analysis for 28-day mortality showed that the odds ratio, 95% confidence interval, and P-value of SOFA were 1.6, 1.2 to 2.1, and <.001, respectively.The predictive model of the SOFA score is able to accurately predict the outcomes of critically ill patients with septic shock undergoing PDGT. [Mh] Termos MeSH primário: Débito Cardíaco Estado Terminal/mortalidade Escores de Disfunção Orgânica Pulso Arterial Choque Séptico/mortalidade [Mh] Termos MeSH secundário: APACHE Adulto Idoso Área Sob a Curva Estado Terminal/terapia Feminino Metas Seres Humanos Modelos Logísticos Masculino Meia-Idade Monitorização Fisiológica/métodos Valor Preditivo dos Testes Estudos Prospectivos [Pt] Tipo de publicação: JOURNAL ARTICLE; OBSERVATIONAL STUDY [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171013 [Lr] Data última revisão: 171013 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170928 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000008111

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[PMID]: 28838544 [Au] Autor: Lippi D [Ad] Endereço: Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla, 3, 50134 Florence, Italy. Electronic address: donatella.lippi@unifi.it. [Ti] Título: Arrhythmias in the History: Lovesickness. [So] Source: Card Electrophysiol Clin;9(3):341-344, 2017 Sep. [Is] ISSN: 1877-9190 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Lovesickness has been termed a real disorder, with a specific cause, pathogenesis, and cure: it has been attested to in the medical literature since classical times and may still have a place in current medicine in the frame of psychiatry and humoral disorders. Although in different cultures there is a general agreement on the symptoms, including fever, agitation, loss of appetite, headache, rapid breathing, and palpitations, the treatments vary greatly in the various cultural contexts. [Mh] Termos MeSH primário: Cardiopatias Amor Transtornos Mentais Pulso Arterial/história [Mh] Termos MeSH secundário: Arritmias Cardíacas Arte/história Técnicas e Procedimentos Diagnósticos/história Cardiopatias/diagnóstico Cardiopatias/história História do Século XV História do Século XVI História do Século XVII História do Século XVIII História Antiga História Medieval Seres Humanos Transtornos Mentais/diagnóstico Transtornos Mentais/história [Pt] Tipo de publicação: HISTORICAL ARTICLE; JOURNAL ARTICLE; REVIEW [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170920 [Lr] Data última revisão: 170920 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170826 [St] Status: MEDLINE

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[PMID]: 28603954 [Au] Autor: Lewis O [Ti] Título: Praxagoras of Cos on Arteries, Pulse and Pneuma. Fragments and Interpretation. [So] Source: Stud Anc Med;48:1-375, 2017. [Is] ISSN: 0925-1421 [Cp] País de publicação: Netherlands [La] Idioma: eng [Mh] Termos MeSH primário: Ar Artérias Fisiologia/história Pulso Arterial/história [Mh] Termos MeSH secundário: Anatomia/história Sistema Cardiovascular Meio Ambiente Grécia História do Século XV História do Século XVI História do Século XVII História Antiga História Medieval Seres Humanos [Pt] Tipo de publicação: HISTORICAL ARTICLE; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170717 [Lr] Data última revisão: 170717 [Sb] Subgrupo de revista: QIS [Da] Data de entrada para processamento: 170613 [St] Status: MEDLINE

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[PMID]: 28560922 [Au] Autor: Evans N [Ti] Título: International experts call for atrial fibrillation screening programme. [So] Source: Nurs Older People;29(5):8-9, 2017 May 31. [Is] ISSN: 1472-0795 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Screening programmes need to be introduced to detect irregular heart rates among older patients, according to an international collaboration of experts. [Mh] Termos MeSH primário: Fibrilação Atrial/diagnóstico Pulso Arterial Acidente Vascular Cerebral/prevenção & controle [Mh] Termos MeSH secundário: Idoso Idoso de 80 Anos ou mais Fibrilação Atrial/complicações Fibrilação Atrial/terapia Eletrocardiografia Seres Humanos Programas de Rastreamento Guias de Prática Clínica como Assunto Acidente Vascular Cerebral/etiologia [Pt] Tipo de publicação: NEWS [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170726 [Lr] Data última revisão: 170726 [Sb] Subgrupo de revista: N [Da] Data de entrada para processamento: 170601 [St] Status: MEDLINE [do] DOI: 10.7748/nop.29.5.8.s7

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[PMID]: 28235461 [Au] Autor: Opio MO; Kellett J; Kitovu Hospital Study Group [Ad] Endereço: Consultant Physician and Medical Director, Kitovu Hospital, Masaka, Uganda. [Ti] Título: How Well Are Pulses Measured? Practice-Based Evidence from an Observational Study of Acutely Ill Medical Patients During Hospital Admission. [So] Source: Am J Med;130(7):863.e13-863.e16, 2017 Jul. [Is] ISSN: 1555-7162 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Although taking a radial pulse is considered to be an essential clinical skill, there have been few reports on how well it is measured in clinical practice, and how its accuracy and precision are influenced by rate, rhythm, and blood pressure. METHODS: This study is a retrospective quality audit carried out as part of a larger ongoing prospective observational trial. The radial pulse rates recorded by 2 research nurses were compared with the electrocardiogram (ECG) heart rates measured on acutely ill medical patients during their admission to a resource-poor hospital in sub-Saharan Africa. RESULTS: There were 619 ECGs performed on 231 patients while they were in the hospital. The median interval between measuring the vital signs and obtaining an ECG was 12.6 minutes (mean 62.3, SD 104.3 minutes). The correlation coefficient between the pulse rate recorded and ECG heart rate was 0.54. The bias between the pulse rate and the ECG heart rate was 1.34, SD 13.51 beats per minute (ie, limits of agreement 26.5 beats per minute). Bias and variance were not influenced by blood and pulse pressure. However, tachycardia increased the variance and was the only independent predictor of a pulse deficit (odds ratio 2.32; 95% confidence interval, 1.53-3.51; chi-squared 17.21; P < .0001). CONCLUSION: Practice-based evidence shows that in acutely ill patients, there is a poor correlation between the radial pulse and the ECG heart rate, and that tachycardia increases the variance and is the only independent predictor of a pulse deficit. [Mh] Termos MeSH primário: Competência Clínica Medicina Baseada em Evidências Hospitalização Pulso Arterial/normas [Mh] Termos MeSH secundário: Adolescente Adulto Idoso Idoso de 80 Anos ou mais Pressão Sanguínea Eletrocardiografia Feminino Frequência Cardíaca Seres Humanos Masculino Auditoria Médica Meia-Idade Estudos Retrospectivos Taquicardia/diagnóstico Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE; OBSERVATIONAL STUDY [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170803 [Lr] Data última revisão: 170803 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170226 [St] Status: MEDLINE

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[PMID]: 28067706 [Au] Autor: Biais M; Mazocky E; Stecken L; Pereira B; Sesay M; Roullet S; Quinart A; Sztark F [Ad] Endereço: From the *CHU de Bordeaux, Service d'Anesthésie Réanimation 3, Bordeaux, France; †INSERM and ‡University Bordeaux, Adaptation cardiovasculaire à l'ischémie, U1034, Pessac, France; §CHU de Bordeaux, Service d'Anesthésie réanimation 1, Bordeaux, France; and ‖Biostatistics Unit (DRCI), Délégation Recherche Clinique and Innovation, CHU de Clermont-Ferrand, Villa annexe IFSI, Rue Montalembert, Clermont-Ferrand Cedex, France. [Ti] Título: Impact of Systemic Vascular Resistance on the Accuracy of the Pulsioflex Device. [So] Source: Anesth Analg;124(2):487-493, 2017 Feb. [Is] ISSN: 1526-7598 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: The accuracy of currently available devices using pulse contour analysis without external calibration for cardiac index (CI) estimation is negatively impacted by hyperdynamic states, low systemic vascular resistance (SVR), and abrupt changes in SVR. The aim of this study was to evaluate the accuracy of a new device, the Pulsioflex (Pulsion Medical System), in patients undergoing liver transplantation. METHODS: Thirty consecutive patients scheduled for liver transplantation were included. CI was monitored using pulmonary arterial catheter (CI-PAC) and Pulsioflex (CI-Pulsio). Simultaneous CI measurements were made intraoperatively at 9 different stages of the procedure. RESULTS: Two hundred seventy pairs of measurements were analyzed. The median CI-Pulsio values (3.3; interquartile range, 2.8-3.8 L·min·m) were significantly different from the median CI-PAC (4.1; interquartile range, 3.1-5.0 L·min·m; P < .0001). Bland and Altman analysis showed a mean bias of 0.8 L·min·m and 95% limit of agreement from -2.5 to 4.1 L·min·m. Percentage error was 65% (95% confidence interval, 60%-71%). Considering the variations in CI between 2 stages, the comparison between changes in CI-PAC and changes in CI-Pulsio showed a mean bias of 0.1 L·min·m and 95% limit of agreement of -2.1 to 2.2 L·min·m. When excluding changes in CI <0.5 L·min·m (154 paired analyzed), the concordance rate was 62% (95% confidence interval, 54%-70%). The bias between CI-PAC and CI-Pulsio was negatively correlated with SVR (r = -0.67, P < .0001). The bias between changes in CI-PAC and changes in CI-Pulsio was also negatively correlated with changes in SVR (r = -0.52, P < .0001). CONCLUSIONS: In patients undergoing liver transplantation, Pulsioflex does not accurately estimate CI. Its accuracy is highly impacted by SVR, and it is not able to track changes in CI when large variations in SVR occur. [Mh] Termos MeSH primário: Débito Cardíaco/fisiologia Pulso Arterial Resistência Vascular/fisiologia [Mh] Termos MeSH secundário: Idoso Pressão Arterial Cateterismo Periférico Feminino Frequência Cardíaca Seres Humanos Transplante de Fígado/métodos Masculino Meia-Idade Monitorização Intraoperatória Contração Miocárdica Reprodutibilidade dos Testes Termodiluição/métodos [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170719 [Lr] Data última revisão: 170719 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170110 [St] Status: MEDLINE [do] DOI: 10.1213/ANE.0000000000001591

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[PMID]: 28060003 [Au] Autor: Marin JA; Woo KY [Ad] Endereço: Joseph A. Marin, BScH, BNSc, RN, School of Nursing, Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada. Kevin Y. Woo, PhD, RN, FAPWCA, School of Nursing, Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada. [Ti] Título: Clinical Characteristics of Mixed Arteriovenous Leg Ulcers: A Descriptive Study. [So] Source: J Wound Ostomy Continence Nurs;44(1):41-47, 2017 Jan/Feb. [Is] ISSN: 1528-3976 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: PURPOSE: The purpose of this study was to identify the clinical characteristics of mixed arteriovenous leg ulcers (MLU) that differentiated them from venous leg ulcers (VLU). DESIGN: Secondary analysis of data from larger electronic database. SUBJECTS AND SETTING: The sample comprised 1007 persons with lower extremity ulcers. Two hundred sixty three individuals with MLU were compared to 744 individuals with VLU; their ankle brachial indices were 0.51-0.90 and 0.91-.30 respectively. Subjects were drawn from community care settings from across Canada. METHODS: Data concerning baseline demographic and pertinent clinical characteristics including ulcer history were collected using multiple validated instruments. The Leg Ulcer Assessment Tool was used to collect demographic and pertinent medical history, The Short Form Health Survey 12 and the Euro Wuol 5D (EQ-5D) were used to measure health related quality of life, the numeric pain scales was used to measure character and intensity of pain. Groups were compared using χ or Mann-Whitney U. RESULTS: Individuals with MLU were significantly older, has lower body mass index, a history of smoking, and more comorbid conditions than subjects with VLU. In many cases, clinical presentation was indicative of significant arterial insufficiency including cool extremities, shiny, cracked and inelastic skin, impaired capillary refill, and weak pedal pulses. Ulcer pain was highly prevalent, but overall pain rating was similar between groups. Mixed arteriovenous leg ulcers were associated with lower health related quality of life, greater mobility impairments, and more deficits in self-care and usual activities. CONCLUSION: Greater knowledge and understanding of the distinct characteristics of MLU is critical for appropriate screening, prevention, assessment and management of persons with this form of leg ulcer. Pain and health related quality of life factors are important considerations when evaluating and managing these patients. [Mh] Termos MeSH primário: Úlcera da Perna/classificação Qualidade de Vida/psicologia Índice de Gravidade de Doença Úlcera Varicosa/classificação [Mh] Termos MeSH secundário: Adulto Idoso Idoso de 80 Anos ou mais Índice Tornozelo-Braço Canadá Dermatite/fisiopatologia Edema/fisiopatologia Feminino Seres Humanos Úlcera da Perna/epidemiologia Masculino Meia-Idade Pulso Arterial/enfermagem Esclerodermia Localizada/fisiopatologia Inquéritos e Questionários Úlcera Varicosa/epidemiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170828 [Lr] Data última revisão: 170828 [Sb] Subgrupo de revista: N [Da] Data de entrada para processamento: 170107 [St] Status: MEDLINE [do] DOI: 10.1097/WON.0000000000000294

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[PMID]: 27743871 [Au] Autor: Salajeghe S; Babyn P; Sarty GE [Ad] Endereço: Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. Electronic address: s.salajeghe@usask.ca. [Ti] Título: Composite pulses for RF phase encoded MRI: A simulation study. [So] Source: Magn Reson Imaging;36:40-48, 2017 Feb. [Is] ISSN: 1873-5894 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: BACKGROUND: In B encoded MRI, a realistic non-linear phase RF encoding coil will generate an inhomogeneous B field that leads to spatially dependent flip angles. The non-linearity of the B phase gradient can be compensated for in the reconstruction, but B inhomogeneity remains a problem. The effect of B inhomogeneity on tip angles for conventional, B encoded MRI, may be minimized using composite pulses. The objective of this study was to explore the feasibility of using composite pulses with non-linear RF phase encoding coils and to identify the most appropriate composite pulse scheme. METHODS: RF encoded signals were simulated via the Bloch equation for various symmetric, asymmetric and antisymmetric composite pulses. The simulated signals were reconstructed using a constrained least squares method. RESULTS: Root mean square reconstruction errors varied from 6% (for an asymmetric composite pulse) to 9.7% (for an antisymmetric composite pulse). CONCLUSION: An asymmetric composite pulse scheme created images with fewer artifacts than other composite pulse schemes in inhomogeneous B and B fields making it the best choice for decreasing the effects of spatially varying flip angles. This is contrary to the conclusion that antisymmetric composite pulses are the best ones to use for spin echo sequences in conventional, B encoded, MRI. [Mh] Termos MeSH primário: Processamento de Imagem Assistida por Computador/métodos Imagem por Ressonância Magnética/métodos [Mh] Termos MeSH secundário: Artefatos Simulação por Computador Estudos de Viabilidade Pulso Arterial Ondas de Rádio [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170719 [Lr] Data última revisão: 170719 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161017 [St] Status: MEDLINE

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[PMID]: 27712091 [Au] Autor: Clarke EC; Fletcher DF; Bilston LE [Ad] Endereço: a Murray Maxwell Biomechanics Laboratory , Institute for Bone and Joint Research, Kolling Institute of Medical Research, Sydney Medical School - Northern, University of Sydney , Sydney , Australia. [Ti] Título: Sustained high-pressure in the spinal subarachnoid space while arterial expansion is low may be linked to syrinx development. [So] Source: Comput Methods Biomech Biomed Engin;20(5):457-467, 2017 Apr. [Is] ISSN: 1476-8259 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Syringomyelia (a spinal cord cyst) usually develops as a result of conditions that cause cerebrospinal fluid (CSF) obstruction. The mechanism of syrinx formation and enlargement remains unclear, though previous studies suggest that the fluid enters via the perivascular spaces (PVS) of the penetrating arteries of the spinal cord, and that alterations in the CSF pulse timing and pressure could contribute to enhanced PVS inflow. This study uses an idealised computational model of the PVS to investigate the factors that influence peri-arterial fluid flow. First, we used three sample patient-specific models to explore whether changes in subarachnoid space (SAS) pressures in individuals with and without syringomyelia could influence PVS inflow. Second we conducted a parametric study to determine how features of the CSF pulse altered perivascular fluid, including alterations to timing and magnitude of the peak SAS pressure, the timing of reversal from high to low pressure (diastolic phase), and the area under the pressure-time curve. The model for the patient with syringomyelia had higher net CSF inflow to the PVS than the two subjects without syringomyelia. In the parametric study, only increasing the area under the high pressure region of the SAS pulse substantially increased PVS inflow, when coupled with a temporal shift in arterial and SAS pulses. This suggests that a period of sustained high SAS pressure while arterial diameter is low may increase net CSF pumping into the PVS. [Mh] Termos MeSH primário: Artérias/fisiopatologia Pressão do Líquido Cefalorraquidiano/fisiologia Medula Espinal/fisiopatologia Espaço Subaracnóideo/fisiopatologia Siringomielia/fisiopatologia [Mh] Termos MeSH secundário: Feminino Frequência Cardíaca/fisiologia Seres Humanos Meia-Idade Modelos Biológicos Pulso Arterial [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1705 [Cu] Atualização por classe: 170501 [Lr] Data última revisão: 170501 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161008 [St] Status: MEDLINE [do] DOI: 10.1080/10255842.2016.1243665

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