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[PMID]:28448390
[Au] Autor:Patino M; Kalin M; Griffin A; Minhajuddin A; Ding L; Williams T; Ishman S; Mahmoud M; Kurth CD; Szmuk P
[Ad] Endereço:From the *Department of Anesthesiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Departments of †Anesthesiology and ‡Clinical Sciences, UT Southwestern and Children's Medical Center, Dallas, Texas; §Division of Biostatistics and Epidemiology, Cincinnati, Ohio; ‖University of Texas Southwestern and Children's Medical Center, Dallas, Texas; ¶Division of Pediatric Otolaryngology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; #Department of Anesthesia and Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio; **Department of Anesthesiology, University of Texas Southwestern and Children's Medical Center, Dallas, Texas; and ††Dallas and Outcome Research Consortium, Cleveland, Ohio.
[Ti] Título:Comparison of Postoperative Respiratory Monitoring by Acoustic and Transthoracic Impedance Technologies in Pediatric Patients at Risk of Respiratory Depression.
[So] Source:Anesth Analg;124(6):1937-1942, 2017 06.
[Is] ISSN:1526-7598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In children, postoperative respiratory rate (RR) monitoring by transthoracic impedance (TI), capnography, and manual counting has limitations. The rainbow acoustic monitor (RAM) measures continuous RR noninvasively by a different methodology. Our primary aim was to compare the degree of agreement and accuracy of RR measurements as determined by RAM and TI to that of manual counting. Secondary aims include tolerance and analysis of alarm events. METHODS: Sixty-two children (2-16 years old) were admitted after tonsillectomy or receiving postoperative patient/parental-controlled analgesia. RR was measured at regular intervals by RAM, TI, and manual count. Each TI or RAM alarm resulted in a clinical evaluation to categorize as a true or false alarm. To assess accuracy and degree of agreement of RR measured by RAM or TI compared with manual counting, a Bland-Altman analysis was utilized showing the average difference and the limits of agreement. Sensitivity and specificity of RR alarms by TI and RAM are presented. RESULTS: Fifty-eight posttonsillectomy children and 4 patient/parental-controlled analgesia users aged 6.5 ± 3.4 years and weighting 35.3 ± 22.7 kg (body mass index percentile 76.6 ± 30.8) were included. The average monitoring time per patient was 15.9 ± 4.8 hours. RAM was tolerated 87% of the total monitoring time. The manual RR count was significantly different from TI (P = .007) with an average difference ± SD of 1.39 ± 10.6 but were not significantly different from RAM (P = .81) with an average difference ± SD of 0.17 ± 6.8. The proportion of time when RR measurements differed by ≥4 breaths was 22% by TI and was 11% by RAM. Overall, 276 alarms were detected (mean alarms/patient = 4.5). The mean number of alarms per patient were 1.58 ± 2.49 and 2.87 ± 4.32 for RAM and TI, respectively. The mean number of false alarms was 0.18 ± 0.71 for RAM and 1.00 ± 2.78 for TI. The RAM was found to have 46.6% sensitivity (95% confidence interval [CI], 0.29-0.64), 95.9% specificity (95% CI, 0.90-1.00), 88.9% positive predictive value (95% CI, 0.73-1.00), and 72.1% negative predictive value (95% CI, 0.61-0.84), whereas the TI monitor had 68.5% sensitivity (95% CI, 0.53-0.84), 72.0% specificity (95% CI, 0.60-0.84), 59.0% positive (95% CI, 0.44-0.74), and 79.5% negative predictive value (95% CI, 0.69-0.90). CONCLUSIONS: In children at risk of postoperative respiratory depression, RR assessment by RAM was not different to manual counting. RAM was well tolerated, had a lower incidence of false alarms, and had better specificity and positive predictive value than TI. Rigorous evaluation of the negative predictive value is essential to determine the role of postoperative respiratory monitoring with RAM.
[Mh] Termos MeSH primário: Acústica
Pulmão/fisiopatologia
Monitorização Fisiológica/métodos
Insuficiência Respiratória/diagnóstico
Taxa Respiratória
Tonsilectomia/efeitos adversos
[Mh] Termos MeSH secundário: Acústica/instrumentação
Adolescente
Criança
Pré-Escolar
Alarmes Clínicos
Impedância Elétrica
Reações Falso-Negativas
Reações Falso-Positivas
Feminino
Seres Humanos
Masculino
Monitorização Fisiológica/instrumentação
Ohio
Projetos Piloto
Pletismografia de Impedância
Valor Preditivo dos Testes
Estudos Prospectivos
Reprodutibilidade dos Testes
Insuficiência Respiratória/etiologia
Insuficiência Respiratória/fisiopatologia
Texas
Fatores de Tempo
Transdutores
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; MULTICENTER STUDY; OBSERVATIONAL STUDY; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1213/ANE.0000000000002062


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[PMID]:28624154
[Au] Autor:Hayes SC; Janda M; Ward LC; Reul-Hirche H; Steele ML; Carter J; Quinn M; Cornish B; Obermair A
[Ad] Endereço:School of Public Health and Social Work, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia. Electronic address: sc.hayes@qut.edu.au.
[Ti] Título:Lymphedema following gynecological cancer: Results from a prospective, longitudinal cohort study on prevalence, incidence and risk factors.
[So] Source:Gynecol Oncol;146(3):623-629, 2017 Sep.
[Is] ISSN:1095-6859
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Cancer-related lymphedema is a debilitating condition that adversely influences function, health and quality of life. The purpose of this study was to assess the prevalence, incidence, and risk factors of lower-limb lymphedema pre- through to 24months post-surgery for gynecological cancer. METHODS: A clinic-based sample of women (n=408) with gynecological cancer participated in a prospective, longitudinal study (2008-2011) using self-reported measures (swelling in one or both legs) and objectively measured lymphedema (bioimpedance spectroscopy) at baseline (pre-surgery), six weeks-three months, 6-12months, and 15-24months post-surgery. RESULTS: At pre-surgery, 15% of women self-reported lymphedema and 27% had measurable evidence of lymphedema. By 24months post-surgery, incidence of new self-reported or measured lymphedema was 45% and 37%, respectively. Three-quarters of these new cases presented by 12-months post-treatment. While lymphedema was transient for some women, 60% had persistent lymphedema. More extensive lymph node dissection, receipt of chemotherapy and radiation therapy, increasing body mass index, insufficient levels of physical activity, diagnosis of vulvar/vaginal cancer and presence of pre-treatment lymphedema were identified as potential risk factors (p<0.05). CONCLUSION: Findings support the need for integration of pre-surgical assessment, and prospective, post-treatment surveillance of lymphedema into gynecological cancer care. Future research exploring the role of maintaining healthy body weight, regular physical activity and education about early detection of lymphedema to improve gynecological cancer survivorship is warranted.
[Mh] Termos MeSH primário: Neoplasias dos Genitais Femininos/cirurgia
Excisão de Linfonodo/efeitos adversos
Linfedema/epidemiologia
Complicações Pós-Operatórias/epidemiologia
[Mh] Termos MeSH secundário: Idoso
Antineoplásicos/uso terapêutico
Austrália/epidemiologia
Índice de Massa Corporal
Feminino
Seres Humanos
Incidência
Estudos Longitudinais
Extremidade Inferior
Meia-Idade
Pletismografia de Impedância
Período Pós-Operatório
Prevalência
Estudos Prospectivos
Radioterapia
Fatores de Risco
Estilo de Vida Sedentário
Autorrelato
Fatores de Tempo
Neoplasias Vaginais/cirurgia
Neoplasias Vulvares/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170619
[St] Status:MEDLINE


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[PMID]:28533135
[Au] Autor:Tischer A; Machha VR; Frontroth JP; Brehm MA; Obser T; Schneppenheim R; Mayne L; Walter Englander S; Auton M
[Ad] Endereço:Division of Hematology, Departments of Internal Medicine and Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA.
[Ti] Título:Enhanced Local Disorder in a Clinically Elusive von Willebrand Factor Provokes High-Affinity Platelet Clumping.
[So] Source:J Mol Biol;429(14):2161-2177, 2017 Jul 07.
[Is] ISSN:1089-8638
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Mutation of the cysteines forming the disulfide loop of the platelet GPIbα adhesive A1 domain of von Willebrand factor (VWF) causes quantitative VWF deficiencies in the blood and von Willebrand disease. We report two cases of transient severe thrombocytopenia induced by DDAVP treatment. Cys1272Trp and Cys1458Tyr mutations identified by genetic sequencing implicate an abnormal gain-of-function phenotype, evidenced by thrombocytopenia, which quickly relapses back to normal platelet counts and deficient plasma VWF. Using surface plasmon resonance, analytical rheology, and hydrogen-deuterium exchange mass spectrometry (HXMS), we decipher mechanisms of A1-GPIbα-mediated platelet adhesion and resolve dynamic secondary structure elements that regulate the binding pathway. Constrained by the disulfide, conformational selection between weak and tight binding states of A1 takes precedence and drives normal platelet adhesion to VWF. Less restrained through mutation, loss of the disulfide preferentially diverts binding through an induced-fit disease pathway enabling high-affinity GPIbα binding and firm platelet adhesion to a partially disordered A1 domain. HXMS reveals a dynamic asymmetry of flexible and ordered regions common to both variants, indicating that the partially disordered A1 lacking the disulfide retains native-like structural dynamics. Both binding mechanisms share common structural and thermodynamic properties, but the enhanced local disorder in the disease state perpetuates high-affinity platelet agglutination, characteristic of type 2B VWD, upon DDAVP-stimulated secretion of VWF leading to transient thrombocytopenia and a subsequent deficiency of plasma VWF, characteristic of type 2A VWD.
[Mh] Termos MeSH primário: Desamino Arginina Vasopressina/efeitos adversos
Proteínas Mutantes/metabolismo
Agregação Plaquetária
Complexo Glicoproteico GPIb-IX de Plaquetas/metabolismo
Trombocitopenia/induzido quimicamente
Trombocitopenia/genética
Fator de von Willebrand/metabolismo
[Mh] Termos MeSH secundário: Substituição de Aminoácidos
Criança
Cisteína/genética
Cisteína/metabolismo
Desamino Arginina Vasopressina/administração & dosagem
Dissulfetos
Feminino
Seres Humanos
Espectrometria de Massas
Proteínas Mutantes/genética
Mutação de Sentido Incorreto
Pletismografia de Impedância
Ressonância de Plasmônio de Superfície
Trombocitopenia/patologia
Fator de von Willebrand/genética
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Disulfides); 0 (Mutant Proteins); 0 (Platelet Glycoprotein GPIb-IX Complex); 0 (adhesion receptor); 0 (von Willebrand Factor); ENR1LLB0FP (Deamino Arginine Vasopressin); K848JZ4886 (Cysteine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170720
[Lr] Data última revisão:
170720
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE


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[PMID]:28338874
[Au] Autor:Kramer MS; Zhang X; Dahhou M; Yang S; Martin RM; Oken E; Platt RW
[Ti] Título:Does Fetal Growth Restriction Cause Later Obesity? Pitfalls in Analyzing Causal Mediators as Confounders.
[So] Source:Am J Epidemiol;185(7):585-590, 2017 Apr 01.
[Is] ISSN:1476-6256
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recent studies finding that small-for-gestational-age (SGA) birth is associated with increased adiposity in childhood and adulthood have been based on analyses "adjusting" for height, weight, or body mass index (BMI; weight (kg)/height (m)2) measured concurrently with the adiposity measurement. To assess the potential for bias due to overadjustment for a causal mediator, we compared 2 approaches to analyzing the association between SGA birth and adiposity outcomes (skinfold thicknesses and bioelectrical impedance measurement of body fat) at age 11.5 years using the same data set in a cohort of Belarusian children followed from birth in 1996-1997 to age 11.5 years in 2008-2010. We 1) studied the association of SGA birth with adiposity, adjusting for baseline covariates only, and 2) made additional regression adjustment for concurrent height, weight, or BMI. The first approach yielded negative associations between SGA birth and all adiposity outcomes. Additional adjustment for concurrent weight or BMI reversed (i.e., to positive) the SGA-adiposity association. To explore the latter anthropometric measures as causal mediators, we also used marginal structural models to estimate the controlled direct effect of SGA birth. That effect was similar to the effect seen with the first approach when modeled on height, was null when modeled on BMI, but was confounded by differences in lean mass versus fat mass when modeled on weight.
[Mh] Termos MeSH primário: Recém-Nascido Pequeno para a Idade Gestacional
Obesidade Pediátrica/etiologia
[Mh] Termos MeSH secundário: Adiposidade
Índice de Massa Corporal
Causalidade
Seres Humanos
Recém-Nascido Pequeno para a Idade Gestacional/fisiologia
Obesidade Pediátrica/epidemiologia
Pletismografia de Impedância
República da Bielorrússia/epidemiologia
Fatores de Risco
Pregas Cutâneas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE
[do] DOI:10.1093/aje/kww109


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[PMID]:28329750
[Au] Autor:Massaroni C; Carraro E; Vianello A; Miccinilli S; Morrone M; Levai IK; Schena E; Saccomandi P; Sterzi S; Dickinson JW; Winter S; Silvestri S
[Ad] Endereço:Research Unit of Measurements and Biomedical Instrumentation, Campus Bio-Medico di Roma University, Rome, Italy.
[Ti] Título:Optoelectronic Plethysmography in Clinical Practice and Research: A Review.
[So] Source:Respiration;93(5):339-354, 2017.
[Is] ISSN:1423-0356
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Optoelectronic plethysmography (OEP) is a non-invasive motion capture method to measure chest wall movements and estimate lung volumes. OBJECTIVES: To provide an overview of the clinical findings and research applications of OEP in the assessment of breathing mechanics across populations of healthy and diseased individuals. METHODS: A bibliographic research was performed with the terms "opto-electronic plethysmography," "optoelectronic plethysmography," and "optoelectronic plethysmograph" in 50 digital library and bibliographic search databases resulting in the selection of 170 studies. RESULTS: OEP has been extensively employed in studies looking at chest wall kinematics and volume changes in chest wall compartments in healthy subjects in relation to age, gender, weight, posture, and different physiological conditions. In infants, OEP has been demonstrated to be a tool to assess disease severity and the response to pharmacological interventions. In chronic obstructive pulmonary disease patients, OEP has been used to test if patients can dynamically hyperinflate or deflate their lungs during exercise. In neuromuscular patients, respiratory muscle strength and chest kinematics have been analyzed. A widespread application of OEP is in tailoring post-operative pulmonary rehabilitation as well as in monitoring volume increases and muscle contributions during exercise. CONCLUSIONS: OEP is an accurate and validated method of measuring lung volumes and chest wall movements. OEP is an appropriate alternative method to monitor and analyze respiratory patterns in children, adults, and patients with respiratory diseases. OEP may be used in the future to contribute to improvements in the therapeutic strategies for respiratory conditions.
[Mh] Termos MeSH primário: Medidas de Volume Pulmonar/métodos
Pletismografia de Impedância
[Mh] Termos MeSH secundário: Exercício
Seres Humanos
Avaliação de Resultados (Cuidados de Saúde)
Doença Pulmonar Obstrutiva Crônica/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE
[do] DOI:10.1159/000462916


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[PMID]:28187148
[Au] Autor:Cova I; Pomati S; Maggiore L; Forcella M; Cucumo V; Ghiretti R; Grande G; Muzio F; Mariani C
[Ad] Endereço:Center for Research and Treatment on Cognitive Dysfunctions, Institute of Clinical Neurology, Department of Clinical Sciences, ASST Fatebenefratelli-Sacco, "Luigi Sacco" University Hospital, Milan, Italy.
[Ti] Título:Nutritional status and body composition by bioelectrical impedance vector analysis: A cross sectional study in mild cognitive impairment and Alzheimer's disease.
[So] Source:PLoS One;12(2):e0171331, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AIMS: Analysis of nutritional status and body composition in Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI). METHODS: A cross-sectional study was performed in a University-Hospital setting, recruiting 59 patients with AD, 34 subjects with MCI and 58 elderly healthy controls (HC). Nutritional status was assessed by anthropometric parameters (body mass index; calf, upper arm and waist circumferences), Mini Nutritional Assessment (MNA) and body composition by bioelectrical impedance vector analysis (BIVA). Variables were analyzed by analysis of variance and subjects were grouped by cognitive status and gender. RESULTS: Sociodemographic variables did not differ among the three groups (AD, MCI and HC), except for females' age, which was therefore used as covariate in a general linear multivariate model. MNA score was significantly lower in AD patients than in HC; MCI subjects achieved intermediate scores. AD patients (both sexes) had significantly (p<0.05) higher height-normalized impedance values and lower phase angles (body cell mass) compared with HC; a higher ratio of impedance to height was found in men with MCI with respect to HC. With BIVA method, MCI subjects showed a significant displacement on the RXc graph on the right side indicating lower soft tissues (Hotelling's T2 test: men = 10.6; women = 7.9;p < 0,05) just like AD patients (Hotelling's T2 test: men = 18.2; women = 16.9; p<0,001). CONCLUSION: Bioelectrical parameters significantly differ from MCI and AD to HC; MCI showed an intermediate pattern between AD and HC. Longitudinal studies are required to investigate if BIVA could reflect early AD-changes in body composition in subjects with MCI.
[Mh] Termos MeSH primário: Doença de Alzheimer/epidemiologia
Composição Corporal
Disfunção Cognitiva/epidemiologia
Estado Nutricional
[Mh] Termos MeSH secundário: Idoso
Estudos de Casos e Controles
Estudos Transversais
Feminino
Seres Humanos
Masculino
Pletismografia de Impedância
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170211
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0171331


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[PMID]:28141516
[Au] Autor:Braun F; Proenca M; Sola J; Thiran JP; Adler A
[Ti] Título:A Versatile Noise Performance Metric for Electrical Impedance Tomography Algorithms.
[So] Source:IEEE Trans Biomed Eng;64(10):2321-2330, 2017 Oct.
[Is] ISSN:1558-2531
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Electrical impedance tomography (EIT) is an emerging technology for real-time monitoring of patients under mechanical ventilation. EIT has the potential to offer continuous medical monitoring while being noninvasive, radiation free, and low cost. Due to their ill-posedness, image reconstruction typically uses regularization, which implies a hyperparameter controlling the tradeoff between noise rejection and resolution or other accuracies. In order to compare reconstruction algorithms, it is common to choose hyperparameter values such that the reconstructed images have equal noise performance (NP), i.e., the amount of measurement noise reflected in the images. For EIT many methods have been suggested, but none work well when the data originate from different measurement setups, such as for different electrode positions or measurement patterns. To address this issue, we propose a new NP metric based on the average signal-to-noise ratio in the image domain. The approach is validated for EIT using simulation experiments on a human thorax model and measurements on a resistor phantom. Results show that the approach is robust to the measurement configuration (i.e., number and position of electrodes, skip pattern) and the reconstruction algorithm used. We propose this novel approach as a way to select optimized measurement configurations and algorithms.
[Mh] Termos MeSH primário: Algoritmos
Pletismografia de Impedância/métodos
Pletismografia de Impedância/normas
Razão Sinal-Ruído
Tomografia/métodos
Tomografia/normas
[Mh] Termos MeSH secundário: Artefatos
Benchmarking
Seres Humanos
Imagens de Fantasmas
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170201
[St] Status:MEDLINE
[do] DOI:10.1109/TBME.2017.2659540


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[PMID]:28113242
[Au] Autor:Seeberg TM; Orr JG; Opsahl H; Austad HO; Roed MH; Dalgard SH; Houghton D; Jones DEJ; Strisland F
[Ti] Título:A Novel Method for Continuous, Noninvasive, Cuff-Less Measurement of Blood Pressure: Evaluation in Patients With Nonalcoholic Fatty Liver Disease.
[So] Source:IEEE Trans Biomed Eng;64(7):1469-1478, 2017 Jul.
[Is] ISSN:1558-2531
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: One promising approach for a continuous, noninvasive, cuff-less ambulatory blood pressure (BP) monitor is to measure the pulse wave velocity or the inversely proportional pulse transit time (PTT), based on electrical and optical physiological measurements in the chest area. A device termed IsenseU-BP+ has been developed for measuring continuous BP, as well as other physiological data. The objective of this paper is to present results from the first clinical evaluation with a wide range of patients. The study was set up to verify whether IsenseU-BP+ can be used to measure raw signals with sufficient quality to derive PTT.  Methods: The test protocol, run 23 times on 18 different patients with nonalcoholic fatty liver disease, includes both supine measurement at rest as well as measurements during indoor cycling. Changes in PTT were compared with the BP changes measured using validated reference sensors.  Results: IsenseU-BP+ measured signals with good quality during rest on 17 of 18 patients despite the high diversity in age, body shape, and body mass index. Evaluation during cycling was difficult due to a lack of good reference measurements. CONCLUSION: IsenseU-BP+ measures PTT with high quality during supine rest and exercise and could therefore be suitable for deriving noninvasive continuous BP, although evaluation during exercise was limited due to inaccurate reference BP measurements. SIGNIFICANCE: Continuous, noninvasive measurement of BP would be highly beneficial in a number of clinical settings. Systems currently considered as the gold standard for the investigation of hypertension carry considerable limitations, which could be overcome by the method proposed here.
[Mh] Termos MeSH primário: Determinação da Pressão Arterial/instrumentação
Hipertensão/diagnóstico
Monitorização Ambulatorial/instrumentação
Hepatopatia Gordurosa não Alcoólica/diagnóstico
Pletismografia de Impedância/instrumentação
Análise de Onda de Pulso/instrumentação
[Mh] Termos MeSH secundário: Adulto
Idoso
Determinação da Pressão Arterial/métodos
Eletrocardiografia Ambulatorial/instrumentação
Desenho de Equipamento
Análise de Falha de Equipamento
Feminino
Seres Humanos
Hipertensão/etiologia
Hipertensão/fisiopatologia
Masculino
Meia-Idade
Monitorização Ambulatorial/métodos
Hepatopatia Gordurosa não Alcoólica/complicações
Hepatopatia Gordurosa não Alcoólica/fisiopatologia
Projetos Piloto
Análise de Onda de Pulso/métodos
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Esfigmomanômetros
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170124
[St] Status:MEDLINE
[do] DOI:10.1109/TBME.2016.2606538


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[PMID]:28068730
[Au] Autor:Zizer E; Seufferlein T; Hänle MM
[Ti] Título:Impaired bolus clearance in combined high-resolution esophageal manometry and impedance measurement helps to differentiate between esophagogastric junction outflow obstruction and achalasia.
[Ti] Título:Eingeschränkte Bolusclearance in der Impedanzmessung stellt einen signifikanten diagnostischen Unterschied zwischen Patienten mit Achalasie und funktioneller Obstruktion dar..
[So] Source:Z Gastroenterol;55(2):129-135, 2017 Feb.
[Is] ISSN:1439-7803
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:High-resolution esophageal manometry (HRM) has improved the diagnostic work-up of esophageal motility disorders. Simultaneous evaluation of bolus clearance delivers useful information about the function of tubular esophagus. We assessed bolus clearance in a combined HRM-impedance examination for esophagogastric junction outflow obstruction (EGJOO) in comparison to achalasia patients. The collected data were assessed in a retrospective analysis. After gastroscopy excluded a mechanical esophageal or gastric obstruction, 142 consecutive patients underwent combined HRM-impedance examination. The assessment and interpretation of the manometry results were done according to the Chicago Classification of esophageal motility disorders v3.0. After classifying the motility disorder, the evaluation of bolus clearance was done according to published studies. All patients with achalasia (n = 24) showed a significantly impaired bolus clearance (< 80 %). Patients with unaffected peristalsis (n = 56) or patients with EGJOO (n = 14) each showed impaired clearance in 7 %, respectively. The evidence of axial hernia was not associated with impaired clearance. Our results demonstrate a significant difference in impedance measurements between EGJOO and achalasia cases. This might be helpful as an additional tool to differentiate between achalasia and EGJOO patients. Furthermore, the role of the combined impedance-HRM investigation for early diagnosis of achalasia in "pre-achalasia" condition or in evaluation of potential progress of EGJOO to achalasia should be evaluated in a prospective study.
[Mh] Termos MeSH primário: Acalasia Esofágica/diagnóstico
Acalasia Esofágica/fisiopatologia
Estenose Esofágica/diagnóstico
Estenose Esofágica/fisiopatologia
Junção Esofagogástrica/fisiopatologia
Manometria/métodos
Pletismografia de Impedância/métodos
[Mh] Termos MeSH secundário: Diagnóstico por Computador/métodos
Diagnóstico Diferencial
Técnicas de Diagnóstico do Sistema Digestório
Feminino
Seres Humanos
Masculino
Meia-Idade
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170110
[St] Status:MEDLINE
[do] DOI:10.1055/s-0042-121267


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[PMID]:28064026
[Au] Autor:Wouters M; Evenhuis HM; Hilgenkamp TI
[Ad] Endereço:Reinaerde, Europalaan 310, 3526 KS, Utrecht, The Netherlands; Erasmus Medical Center, Department of General Practice, Intellectual Disability Medicine, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands. Electronic address: m.wouters.2@erasmusmc.nl.
[Ti] Título:Systematic review of field-based physical fitness tests for children and adolescents with intellectual disabilities.
[So] Source:Res Dev Disabil;61:77-94, 2017 Feb.
[Is] ISSN:1873-3379
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Testing physical fitness in children and adolescents with intellectual disabilities (ID) can be challenging. This review provides an overview on psychometric properties of field-based physical fitness tests studied in children and adolescents with ID. METHODS: A literature search was performed in March 2014. Studies were included if they evaluated feasibility, reliability and/or validity of a field-based physical fitness test in children and adolescents with ID. RESULTS: Twenty-six papers met the inclusion criteria and described 18 tests on body composition (4), muscular strength (4), muscular endurance (6), and cardiorespiratory fitness (4). Best results on feasibility, reliability and/or validity were found for bioelectric impedance analysis, body mass index, grip strength, arm hang and distance run/walk tests. These results were mainly found in adolescents with mild to moderate ID. CONCLUSION: Some tests were found feasible, reliable and/or valid in subgroups of children and adolescents with ID, but not in children and adolescents with all ages and levels of ID. Further assessment is needed before wider application in all children and adolescents with ID.
[Mh] Termos MeSH primário: Teste de Esforço/métodos
Deficiência Intelectual
Aptidão Física
[Mh] Termos MeSH secundário: Adolescente
Composição Corporal
Índice de Massa Corporal
Aptidão Cardiorrespiratória
Criança
Estudos de Viabilidade
Força da Mão
Seres Humanos
Força Muscular
Resistência Física
Pletismografia de Impedância
Reprodutibilidade dos Testes
Índice de Gravidade de Doença
Teste de Caminhada
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170718
[Lr] Data última revisão:
170718
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170109
[St] Status:MEDLINE



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