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[PMID]:29190137
[Au] Autor:Hughes JW; Muegge BD; Tobin GS; Litvin M; Sun L; Saenz JB; Gyawali CP; McGill JB
[Ti] Título:HIGH-RISK GASTRIC PATHOLOGY AND PREVALENT AUTOIMMUNE DISEASES IN PATIENTS WITH PERNICIOUS ANEMIA.
[So] Source:Endocr Pract;23(11):1297-1303, 2017 Nov.
[Is] ISSN:1530-891X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Pernicious anemia (PA) develops from atrophic gastritis due to autoimmune destruction of parietal cells and results in achlorhydria, vitamin B12 and iron deficiencies, anemia, neurologic deficits, and premalignant and malignant stomach lesions. We report the presentation, diagnosis and gastric complications of PA in patients from an endocrinology practice. METHODS: Thirty-four patients (31 female, 3 male) with PA who underwent esophagogastroduodenoscopy (EGD) or gastrectomy were identified. Pertinent clinical, laboratory, and pathology findings were reviewed and summarized. RESULTS: The mean age of patients was 58.6 ± 14.2 years; the onset of PA was age 50.2 ± 15.3 years. Anemia reflected vitamin B12 and/or iron deficiencies. Parietal cell antibodies (PCA) were detected in 97% of patients, and intrinsic factor blocking antibody (IFBA) was found in 52%. Fasting gastrin and chromogranin A levels were elevated (1,518.0 ± 1,588.3 pg/mL, and 504.9.1 ± 1,524.9 ng/mL respectively). Autoimmune or immunologic diseases (AIDs) were present in 32/34 patients. Stomach pathology showed premalignant or malignant lesions in 26 patients, including gastric neuroendocrine tumors (GNETs) in 6 and adenocarcinoma in 1. One patient presented with neurologic symptoms and subacute combined degeneration of the posterior column of the spinal cord. CONCLUSION: PA should be suspected in patients with unexplained anemia or neurologic symptoms. The diagnosis of PA relies on fasting gastrin and gastric auto-antibody testing, in addition to hematologic evaluation. EGD with measurement of gastric pH and biopsies of the fundus and antrum identifies patients with achlorhydria, atrophic gastritis, and premalignant and malignant stomach lesions. EGD surveillance of patients with high-risk stomach lesions is recommended. ABBREVIATIONS: AID = autoimmune or immunologic disease; EGD = esophagogastroduodenoscopy; GNET = gastric neuroendocrine tumor; IFBA = intrinsic factor blocking antibody; PA = pernicious anemia; PCA = parietal cell antibody; T1D = type 1 diabetes.
[Mh] Termos MeSH primário: Anemia Perniciosa/etiologia
Doenças Autoimunes/complicações
Mucosa Gástrica/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Endoscopia do Sistema Digestório
Feminino
Gastrectomia
Gastrinas/sangue
Gastrite Atrófica/complicações
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gastrins)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.4158/EP-2017-0056


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[PMID]:28746592
[Au] Autor:Ferrari AP; Martins FP
[Ad] Endereço:Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
[Ti] Título:Endoscopic surveillance of extensive esophageal papillomatosis not amenable to endoscopic therapy.
[So] Source:Einstein (Sao Paulo);15(3):363-365, 2017 Jul-Sep.
[Is] ISSN:2317-6385
[Cp] País de publicação:Brazil
[La] Idioma:eng; por
[Ab] Resumo:We present two cases of esophageal papillomatosis, a very rare reported disease leading to dysphagia and did not improve after endoscopic treatment. Both patients refused surgery and they were followed-up for 3 years, but no significant clinical or endoscopic changes were seen.
[Mh] Termos MeSH primário: Transtornos de Deglutição/diagnóstico
Endoscopia do Sistema Digestório
Neoplasias Esofágicas/diagnóstico
Papiloma/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Transtornos de Deglutição/etiologia
Endoscopia do Sistema Digestório/efeitos adversos
Neoplasias Esofágicas/complicações
Feminino
Seres Humanos
Papiloma/complicações
[Pt] Tipo de publicação:CASE REPORTS
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE


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[PMID]:29208252
[Au] Autor:Khalaf M; Brock AS; Castell D
[Ad] Endereço:Division of Gastroenterology & Hepatology, Medical University of South Carolina, Charleston, South Carolina. Electronic address: khalaf@musc.edu.
[Ti] Título:Sporadic Fundic Gland Polyps and Gastric Acid Suppression Level.
[So] Source:Am J Med Sci;354(6):561-564, 2017 12.
[Is] ISSN:1538-2990
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Fundic gland polyps (FGPs) are a common endoscopic finding and are known to be associated with proton pump inhibitors (PPIs) use. It is not known if their prevalence is affected by gastric acidity levels. This study aimed to assess whether there is a correlation between FGPs and gastric acidity levels as identified on 24-hour ambulatory impedance-pH studies in patients on PPI therapy. METHODS: We performed a review of 402 consecutive patients who take at least once daily PPI and underwent esophagogastroduodenoscopy with combined impedance-pH studies in the same setting (time and place) between January 2010 and December 2014. Patients were classified into 2 groups based on the presence or absence of biopsy-confirmed FGPs during endoscopy. RESULTS: Of the 402 patients, 30 (7%) had FGPs. One of these polyps was found with low-grade dysplasia. There was no significant difference of the distributions of the [H ] in the FGPs versus the nonpolyp groups (P = 0.741). There was no significant difference between the 2 groups regarding PPI dose frequency regimens (once and twice) (P = 0.074). However, we found weak ordinal association with PPI duration (P = 0.01) (Spearman = 0.1). CONCLUSIONS: FGPs are common endoscopic lesions. Incidence of dysplasia in FGPs is not only rare, but also of unknown clinical significance. Although they seem to be associated with PPIs, the mechanism remains unclear, as we found no correlation between the presence of FGPs and gastric acid control or PPI dose. Future studies would be useful to elucidate an alternate mechanism.
[Mh] Termos MeSH primário: Ácido Gástrico/secreção
Pólipos/fisiopatologia
Neoplasias Gástricas/fisiopatologia
[Mh] Termos MeSH secundário: Idoso
Endoscopia do Sistema Digestório
Feminino
Determinação da Acidez Gástrica
Seres Humanos
Concentração de Íons de Hidrogênio
Masculino
Meia-Idade
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


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[PMID]:28455456
[Au] Autor:Inayat F; Ullah W; Hussain Q; Shafique K
[Ad] Endereço:New York-Presbyterian Hospital, Weill Cornell Medical College, New York City, New York, USA.
[Ti] Título:Crohn's disease presenting as gastric outlet obstruction: a therapeutic challenge?
[So] Source:BMJ Case Rep;2017, 2017 Apr 28.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Isolated gastric Crohn's disease with initial presentation related to gastric outlet obstruction is an unusual clinicopathological entity. We undertake here a literature review of this rare initial presentation of isolated gastric Crohn's disease and discuss the formidable diagnostic and therapeutic challenges encountered in such patients.
[Mh] Termos MeSH primário: Doença de Crohn/complicações
Doença de Crohn/patologia
Obstrução da Saída Gástrica/complicações
Obstrução da Saída Gástrica/patologia
[Mh] Termos MeSH secundário: Adulto
Doença de Crohn/diagnóstico
Endoscopia do Sistema Digestório/métodos
Endoscopia Gastrointestinal/métodos
Feminino
Obstrução da Saída Gástrica/diagnóstico por imagem
Gastrite/diagnóstico
Gastrite/etiologia
Seres Humanos
Estômago/patologia
Gastropatias/patologia
Tomografia Computadorizada por Raios X/métodos
Resultado do Tratamento
Perda de Peso
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


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[PMID]:29381987
[Au] Autor:Yan GW; Deng JF; Bhetuwal A; Yang GQ; Fu QS; Chen H; Hu N; Zeng H; Fan XP; Yan GW; Wu XL
[Ad] Endereço:Department of Radiology, Suining Central Hospital, Suining.
[Ti] Título:A case report and literature review of barium sulphate aspiration during upper gastrointestinal examination.
[So] Source:Medicine (Baltimore);96(47):e8821, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Even though barium sulphate aspiration during upper gastrointestinal examination is a well-known phenomenon, complication such as long-term lung injury and death may still occur. This may depend upon the concentration, amount, anatomy, or certain predisposing factors. PATIENT CONCERNS: A 47-year-old woman who had a barium swallow to screen for foreign body in esophagus. DIAGNOSES: Chest radiographs demonstrated massive barium sulphate depositions in her trachea and inferior lobe of right lung. INTERVENTIONS: A chest x-ray was done that revealed massive barium sulphate depositions in her trachea and lower lobe of right lung. As the patient did not have further complaints, she requested a transfer to West China Hospital of Sichuan University, the hospital being near her residence, for further treatment. She eventually recovered and was discharged after 1 week. OUTCOMES: There were 23 articles (22 English and 1 Chinese with 17 men and 11 women) included in the study. The risk factors of barium sulphate aspiration are dysphagia (10/28, 35.71%) followed by esophageal obstruction caused by tumor (5/28, 17.86%) and foreign body in esophagus (3/28, 10.71%). Infants (5/28, 17.86%) are also one of the high-risk population. Both the lungs were affected in most of the patients (21/28, 75%). Majority of the presentation in patients (21/28, 75%) were dyspnea, hypoxemia, acute respiratory distress syndrome (ARDS), or respiratory failure. Few patients (7/28, 25%) showed no symptoms or mild symptoms such as cough and fever. Barium sulphate aspiration can be life-threatening with a high risk of death (nearly 40%). LESSONS: When performing an upper gastrointestinal examination with barium sulphate, careful consideration of concentration and amount of barium sulphate and that of risk factors should be undertaken so as to avoid life-threatening aspiration.
[Mh] Termos MeSH primário: Sulfato de Bário/efeitos adversos
Meios de Contraste/efeitos adversos
Endoscopia do Sistema Digestório/efeitos adversos
Esôfago/diagnóstico por imagem
Corpos Estranhos/diagnóstico por imagem
Aspiração Respiratória/induzido quimicamente
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Meia-Idade
Radiografia
Traqueia/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Contrast Media); 25BB7EKE2E (Barium Sulfate)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008821


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[PMID]:29369216
[Au] Autor:Dore MP; Cipolli A; Ruggiu MW; Manca A; Bassotti G; Pes GM
[Ad] Endereço:Dipartimento di Medicina Clinica e Sperimentale.
[Ti] Título:Helicobacter pylori eradication may influence timing of endoscopic surveillance for gastric cancer in patients with gastric precancerous lesions: A retrospective study.
[So] Source:Medicine (Baltimore);97(4):e9734, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chronic atrophic gastritis and intestinal metaplasia related to Helicobacter pylori infection, are major risk factors for gastric adenocarcinoma. Eradication of H pylori and endoscopy surveillance of precancerous lesions may reduce the risk and/or lead to early detection of gastric cancer improving survival. In this study, the progression of precancerous lesions after H pylori treatment was evaluated.Patients with incomplete or complete intestinal metaplasia and/or gastric atrophy at the index endoscopy, were examined for the extension/histological worsening of precancerous lesions at the endoscopy surveillance for gastric cancer. Progression of lesions was evaluated according to H pylori status, age, and sex. Cox proportional hazard regression model and Kaplan-Meier curves were used to evaluate the strength of predictors for lesions progression.Among 105 patients (61 women) H pylori negative patients showed a milder worsening of gastric lesions between index and surveillance endoscopy compared with patients positive for the infection (log-rank test: P < .0001, P = .012, and P = .032 for antrum, angulus, and corpus, respectively). The Cox regression model showed persistence of H pylori infection (hazard ratio = 4.436; P < .0001) as the only relevant factor for lesion progression, whereas age >65 years and sex were not significant predictors.According to literature our results demonstrate that H pylori eradication is the major factor able to delay gastric precancerous lesions progression. Time interval for endoscopic surveillance in patients negative for H pylori infection and with gastric precancerous lesions may be extended.
[Mh] Termos MeSH primário: Endoscopia do Sistema Digestório/métodos
Infecções por Helicobacter/tratamento farmacológico
Helicobacter pylori/efeitos dos fármacos
Vigilância da População/métodos
Lesões Pré-Cancerosas/diagnóstico
Neoplasias Gástricas/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Progressão da Doença
Detecção Precoce de Câncer/métodos
Feminino
Infecções por Helicobacter/complicações
Seres Humanos
Intestinos/microbiologia
Intestinos/patologia
Masculino
Metaplasia/diagnóstico
Metaplasia/microbiologia
Meia-Idade
Lesões Pré-Cancerosas/microbiologia
Modelos de Riscos Proporcionais
Análise de Regressão
Estudos Retrospectivos
Fatores de Risco
Neoplasias Gástricas/microbiologia
Fatores de Tempo
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009734


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[PMID]:28748917
[Au] Autor:Smyth EC; Lagergren J; Fitzgerald RC; Lordick F; Shah MA; Lagergren P; Cunningham D
[Ad] Endereço:Department of Gastrointestinal Oncology, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.
[Ti] Título:Oesophageal cancer.
[So] Source:Nat Rev Dis Primers;3:17048, 2017 Jul 27.
[Is] ISSN:2056-676X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Oesophageal cancer is the sixth most common cause of cancer-related death worldwide and is therefore a major global health challenge. The two major subtypes of oesophageal cancer are oesophageal squamous cell carcinoma (OSCC) and oesophageal adenocarcinoma (OAC), which are epidemiologically and biologically distinct. OSCC accounts for 90% of all cases of oesophageal cancer globally and is highly prevalent in the East, East Africa and South America. OAC is more common in developed countries than in developing countries. Preneoplastic lesions are identifiable for both OSCC and OAC; these are frequently amenable to endoscopic ablative therapies. Most patients with oesophageal cancer require extensive treatment, including chemotherapy, chemoradiotherapy and/or surgical resection. Patients with advanced or metastatic oesophageal cancer are treated with palliative chemotherapy; those who are human epidermal growth factor receptor 2 (HER2)-positive may also benefit from trastuzumab treatment. Immuno-oncology therapies have also shown promising early results in OSCC and OAC. In this Primer, we review state-of-the-art knowledge on the biology and treatment of oesophageal cancer, including screening, endoscopic ablative therapies and emerging molecular targets, and we discuss best practices in chemotherapy, chemoradiotherapy, surgery and the maintenance of patient quality of life.
[Mh] Termos MeSH primário: Adenocarcinoma/epidemiologia
Carcinoma de Células Escamosas/epidemiologia
Neoplasias Esofágicas/epidemiologia
Neoplasias Esofágicas/patologia
[Mh] Termos MeSH secundário: Adenocarcinoma/patologia
África Oriental/epidemiologia
Idoso
Idoso de 80 Anos ou mais
Antineoplásicos Imunológicos/uso terapêutico
Carcinoma de Células Escamosas/patologia
Quimiorradioterapia/métodos
Endoscopia do Sistema Digestório/métodos
Neoplasias Esofágicas/tratamento farmacológico
Neoplasias Esofágicas/cirurgia
Feminino
Seres Humanos
Masculino
Meia-Idade
Prognóstico
Receptor ErbB-2/metabolismo
América do Sul/epidemiologia
Taxa de Sobrevida
Trastuzumab/uso terapêutico
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antineoplastic Agents, Immunological); EC 2.7.10.1 (ERBB2 protein, human); EC 2.7.10.1 (Receptor, ErbB-2); P188ANX8CK (Trastuzumab)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1038/nrdp.2017.48


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[PMID]:27778205
[Au] Autor:Wolf WA; Piazza NA; Gebhart JH; Rusin S; Covey S; Higgins LL; Beitia R; Speck O; Woodward K; Cotton CC; Runge TM; Eluri S; Woosley JT; Shaheen NJ; Dellon ES
[Ad] Endereço:Division of Gastroenterology and Hepatology, Center for Esophageal Diseases and Swallowing, University of North Carolina at Chapel Hill, CB#7080 Bioinformatics Building, 130 Mason Farm Rd., Chapel Hill, NC, 27599-7080, USA.
[Ti] Título:Association Between Body Mass Index and Clinical and Endoscopic Features of Eosinophilic Esophagitis.
[So] Source:Dig Dis Sci;62(1):143-149, 2017 01.
[Is] ISSN:1573-2568
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Because eosinophilic esophagitis (EoE) causes dysphagia, esophageal narrowing, and strictures, it could result in low body mass index (BMI), but there are few data assessing this. AIM: To determine whether EoE is associated with decreased BMI. METHODS: We conducted a prospective study at the University of North Carolina from 2009 to 2013 enrolling consecutive adults undergoing outpatient EGD. BMI and endoscopic findings were recorded. Incident cases of EoE were diagnosed per consensus guidelines. Controls had either reflux or dysphagia, but not EoE. BMI was compared between cases and controls and by endoscopic features. RESULTS: Of 120 EoE cases and 297 controls analyzed, the median BMI was lower in EoE cases (25 vs. 28 kg/m , p = 0.002). BMI did not differ by stricture presence (26 vs. 26 kg/m , p = 0.05) or by performance of dilation (26 vs. 27 kg/m for undilated; p = 0.16). However, BMI was lower in patients with narrow caliber esophagus (24 vs. 27 kg/m , p < 0.001). EoE patients with narrow caliber esophagus also had decreased BMI compared to controls with narrow caliber esophagi (24 vs. 27 kg/m , p = 0.001). On linear regression after adjustment for age, race, and gender, narrowing decreased BMI by 2.3 kg/m [95% CI -4.1, -0.6]. CONCLUSIONS: BMI is lower in EoE cases compared to controls, and esophageal narrowing, but not focal stricture, is associated with a lower BMI in patients with EoE. Weight loss or low BMI in a patient suspected of having EoE should raise concern for esophageal remodeling causing narrow caliber esophagus.
[Mh] Termos MeSH primário: Transtornos de Deglutição/epidemiologia
Esofagite Eosinofílica/epidemiologia
Estenose Esofágica/epidemiologia
Magreza/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Índice de Massa Corporal
Estudos de Casos e Controles
Estudos de Coortes
Transtornos de Deglutição/etiologia
Dilatação
Endoscopia do Sistema Digestório
Esofagite Eosinofílica/complicações
Esofagite Eosinofílica/patologia
Estenose Esofágica/etiologia
Estenose Esofágica/patologia
Estenose Esofágica/cirurgia
Esôfago/patologia
Esôfago/cirurgia
Feminino
Hérnia Hiatal/epidemiologia
Seres Humanos
Incidência
Modelos Lineares
Masculino
Meia-Idade
North Carolina/epidemiologia
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180101
[Lr] Data última revisão:
180101
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1007/s10620-016-4357-1


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[PMID]:27778204
[Au] Autor:Fortinsky KJ; Kevans D; Qiang J; Xu W; Bellolio F; Steinhart H; Milgrom R; Greenberg G; Cohen Z; Macrae H; Stempak J; McLeod R; Silverberg MS
[Ad] Endereço:University of Toronto, Toronto, Canada. kyle.fortinsky@mail.utoronto.ca.
[Ti] Título:Rates and Predictors of Endoscopic and Clinical Recurrence After Primary Ileocolic Resection for Crohn's Disease.
[So] Source:Dig Dis Sci;62(1):188-196, 2017 01.
[Is] ISSN:1573-2568
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIMS: The utility of postoperative medical prophylaxis (POMP) and the treatment of mild endoscopic recurrence remain controversial. METHODS: This study is a retrospective review of patients undergoing a primary ileocolic resection for CD at a single academic center. Endoscopic recurrence (ER) was defined using the Rutgeerts score (RS), and clinical recurrence (CR) was defined as symptoms of CD with endoscopic or radiologic evidence of neo-terminal ileal disease. RESULTS: There were 171 patients who met inclusion criteria. The cumulative probability of ER (RS ≥ i-1) at 1, 2, and 5 years was 29, 51, and 77 %, respectively. The only independent predictors of ER were the absence of POMP (HR 1.50; P = 0.03) and penetrating disease behavior (HR 1.50; P = 0.05). The cumulative probability of CR at 1, 2, and 5 years was 8, 13, and 27 %, respectively. There was a higher rate of clinical recurrence in patients with RS-2 compared to RS-1 on the initial postoperative endoscopy (HR 2.50; P = 0.02). In 11 patients not exposed to POMP with i-1 on initial endoscopy, only 2 patients (18 %) progressed endoscopically during the study period while 5 patients (45 %) regressed to i-0 on subsequent endoscopy without treatment. CONCLUSIONS: Postoperative medical prophylaxis decreased the likelihood of ER while certain phenotypes of CD appear to increase the risk of developing ER and CR. There may be a role for watchful waiting in patients with mild endoscopic recurrence on the initial postoperative endoscopy.
[Mh] Termos MeSH primário: Corticosteroides/uso terapêutico
Anti-Inflamatórios não Esteroides/uso terapêutico
Colectomia
Doença de Crohn/cirurgia
Fatores Imunológicos/uso terapêutico
Cuidados Pós-Operatórios/métodos
Prevenção Secundária/métodos
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Idoso
Colo/cirurgia
Doença de Crohn/diagnóstico
Doença de Crohn/prevenção & controle
Endoscopia do Sistema Digestório
Feminino
Seguimentos
Seres Humanos
Íleo/cirurgia
Estimativa de Kaplan-Meier
Masculino
Mesalamina/uso terapêutico
Meia-Idade
Modelos de Riscos Proporcionais
Recidiva
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Immunologic Factors); 4Q81I59GXC (Mesalamine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171212
[Lr] Data última revisão:
171212
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1007/s10620-016-4351-7


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[PMID]:28982917
[Au] Autor:Lee AA; Poddar N; Hammami MB; Veerapong J; Cao D; Lai JP
[Ad] Endereço:Department of Pathology, Saint Louis University School of Medicine, St. Louis, MO, U.S.A.
[Ti] Título:Gastric Spindle Cell Neuroendocrine Tumor Mimicking Gastrointestinal Stromal Tumor: Unique Morphology and Diagnostic Pitfall.
[So] Source:Anticancer Res;37(10):5893-5897, 2017 10.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:Gastric neuroendocrine tumors (GNETs) with spindle cell morphology are extremely rare. We present a case of a 49-year-old female patient with a history of systemic lupus erythematosus, Sjogren's syndrome, and gastroesophageal reflux disease. She was initially thought to have a spindle cell gastrointestinal stromal tumor per histological studies of the fundic polypectomy samples. Immunohistochemically, the tumor cells were negative for CD117, and CD34, but positive for chromogranin, synaptophysin, and CD56 with a 6% Ki-67 index, consistent with a spindle cell-type well differentiated neuroendocrine tumor, World Health Organization (WHO) Grade 2. To the best of our knowledge, this is the first case report of a gastric spindle cell neuroendocrine tumor in the English literature.
[Mh] Termos MeSH primário: Carcinoma Neuroendócrino/patologia
Tumores do Estroma Gastrointestinal/patologia
Neoplasias Gástricas/patologia
[Mh] Termos MeSH secundário: Biomarcadores Tumorais/análise
Biópsia
Carcinoma Neuroendócrino/química
Carcinoma Neuroendócrino/cirurgia
Diagnóstico Diferencial
Erros de Diagnóstico/prevenção & controle
Endoscopia do Sistema Digestório
Feminino
Gastrectomia
Tumores do Estroma Gastrointestinal/química
Seres Humanos
Imuno-Histoquímica
Meia-Idade
Valor Preditivo dos Testes
Neoplasias Gástricas/química
Neoplasias Gástricas/cirurgia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE



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