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[PMID]:29334923
[Au] Autor:Park K; Shin J; Lee J
[Ad] Endereço:Department of Ophthalmology, Pusan National University School of Medicine, #179 Gudeok-ro, Seo-gu, Busan, 602-739, South Korea.
[Ti] Título:Relationship between corneal biomechanical properties and structural biomarkers in patients with normal-tension glaucoma: a retrospective study.
[So] Source:BMC Ophthalmol;18(1):7, 2018 Jan 15.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We evaluated the relationships between corneal biomechanical properties and structural parameters in patients with newly diagnosed, untreated normal-tension glaucoma (NTG). METHODS: All subjects were evaluated using an Ocular Response Analyzer (ORA) measuring corneal hysteresis (CH) and the corneal resistance factor (CRF). Central corneal thickness (CCT), Goldmann applanation tonometric (GAT) data, axial length, and the spherical equivalent (SE), were also measured. Confocal scanning laser ophthalmoscopy was performed with the aid of a Heidelberg retina tomograph (HRT III). We sought correlations between HRT parameters and different variables including CCT, CH, and the CRF. Multiple linear regression analysis was performed to identify significant associations between corneal biomechanical properties and optic nerve head parameters. RESULTS: We enrolled 95 eyes of 95 NTG patients and 93 eyes of 93 normal subjects. CH and the CRF were significantly lower in more advanced glaucomatous eyes (P = 0.001, P = 0.008, respectively). The rim area, rim volume, linear cup-to-disc ratio (LCDR), and mean retinal nerve fiber layer (RNFL) thickness were significantly worse in more advanced glaucomatous eyes (P < 0.001, P < 0.001, P < 0.001, and P = 0.001). CH was directly associated with rim area, rim volume, and mean RNFL thickness (P = 0.012, P = 0.028, and P = 0.043) and inversely associated with LCDR (P = 0.015), after adjusting for age, axial length, CCT, disc area, GAT data, and SE. However, in normal subjects, there were no significant associations between corneal biomechanical properties and HRT parameters. CONCLUSIONS: A lower CH is significantly associated with a smaller rim area and volume, a thinner RNFL, and a larger LCDR, independent of disc size, corneal thickness, intraocular pressure, and age.
[Mh] Termos MeSH primário: Córnea/fisiopatologia
Pressão Intraocular/fisiologia
Glaucoma de Baixa Tensão/fisiopatologia
Oftalmoscopia/métodos
[Mh] Termos MeSH secundário: Fenômenos Biomecânicos
Córnea/patologia
Estudos Transversais
Feminino
Seguimentos
Seres Humanos
Glaucoma de Baixa Tensão/diagnóstico
Masculino
Meia-Idade
Estudos Retrospectivos
Tonometria Ocular
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0673-x


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[PMID]:28744552
[Au] Autor:Chen Q; Ma Q; Wu C; Tan F; Chen F; Wu Q; Zhou R; Zhuang X; Lu F; Qu J; Shen M
[Ad] Endereço:School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
[Ti] Título:Macular Vascular Fractal Dimension in the Deep Capillary Layer as an Early Indicator of Microvascular Loss for Retinopathy in Type 2 Diabetic Patients.
[So] Source:Invest Ophthalmol Vis Sci;58(9):3785-3794, 2017 07 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To determine the ability of fractal dimension to detect early changes in the retinal microvascular network imaged by optical coherence tomography angiography (OCT-A) in type 2 diabetic patients. Methods: Sixty-seven patients with type 2 diabetic mellitus (DM) (48 with no diabetic retinopathy [DR], 19 with minimal DR) and 40 control subjects. Macular OCT-A images of the superficial and deep retinal capillary layers in a 2.5-mm diameter concentric annular zone (excluding the foveal avascular zone) were subdivided into six annular rings and four quadrants. A custom automated algorithm was developed to quantify the complexity and density of the two retinal capillary layers by fractal analysis. Results: Compared to controls, the fractal dimensional parameter (Dbox) of the two retinal capillary layers in most regions was significantly lower in diabetic patients with minimal DR (P < 0.05). The Dbox of the diabetic patients with no DR was also decreased in most regions of the deep retinal capillary layer (P < 0.05), but not in the superficial retinal capillary layer (P > 0.05). Based on the receiver operating characteristic curve analysis, the Dbox values for the deep retinal capillary layer had the highest index to discriminate diabetic patients with and without minimal DR from controls. Conclusions: Fractal dimension based on OCT-A has the potential to quantitatively characterize retinal microvascular changes in the early stage of DM. Changes in the fractal dimension in the deep retinal capillary layer could be an early indicator of microvasculature changes associated with retinopathy in type 2 diabetic patients.
[Mh] Termos MeSH primário: Capilares/patologia
Diabetes Mellitus Tipo 2/diagnóstico
Retinopatia Diabética/diagnóstico
Fractais
Vasos Retinianos/patologia
[Mh] Termos MeSH secundário: Algoritmos
Glicemia/metabolismo
Índice de Massa Corporal
Angiografia por Tomografia Computadorizada
Diabetes Mellitus Tipo 2/fisiopatologia
Retinopatia Diabética/fisiopatologia
Feminino
Hemoglobina A Glicada/metabolismo
Seres Humanos
Masculino
Meia-Idade
Oftalmoscopia
Curva ROC
Estudos Retrospectivos
Tomografia de Coerência Óptica
Acuidade Visual/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Glycated Hemoglobin A); 0 (hemoglobin A1c protein, human)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-21461


  3 / 7581 MEDLINE  
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[PMID]:29290016
[Au] Autor:Moramarco A; Giustini S; Nofroni I; Mallone F; Miraglia E; Iacovino C; Calvieri S; Lambiase A
[Ad] Endereço:Department of Sense Organs, 'Sapienza' University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
[Ti] Título:Near-infrared imaging: an in vivo, non-invasive diagnostic tool in neurofibromatosis type 1.
[So] Source:Graefes Arch Clin Exp Ophthalmol;256(2):307-311, 2018 Feb.
[Is] ISSN:1435-702X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Only a few reports in the literature have investigated the presence of ocular abnormalities in neurofibromatosis type 1 (NF-1) patients. The aim of this study was to evaluate the prevalence of ocular abnormalities in a large population of NF1 patients, focusing on the choroidal changes. METHODS: This study was conducted on 160 consecutive patients with NF1 and 106 sex- and age-matched healthy subjects (control). Each patient underwent a complete ophthalmological examination inclusive of best-corrected visual acuity, intraocular pressure measurement, slit-lamp biomicroscopy, indirect fundus biomicroscopy, and near-infrared reflectance (NIR) retinography by using the spectral domain OCT. Moreover, all patients underwent complete dermatological exam and 1.5-Tesla MRI scan of the brain to assess the presence of optic nerve gliomas. RESULTS: Choroidal abnormalities were detected in 97% of patients, with a positive predictive value of 100% and a negative predictive value of 96.4%. Interestingly, a small number of patients (4/160; 2.5%) showed Lisch nodules without choroidal abnormalities, whereas a larger number of patents (22/160; 13.75%) presented choroidal lesions in absence of Lisch nodules. None of the patients showed the absence of both choroidal lesions and Lisch nodules. The number of choroidal lesions increased with age (r = 0.364, p = 0.0001) and with the severity of pathology (r = 0.23, p = 0.003). Any statistically significant correlation between choroidal lesions, visual acuity, and intraocular pressure was observed. CONCLUSIONS: NIR imaging represents an in vivo, non-invasive, sensitive and reproducible exam to detect choroidal nodules in NF-1 patients, suggesting that choroidal changes may represent an additional diagnostic criteria for NF1.
[Mh] Termos MeSH primário: Doenças da Coroide/diagnóstico
Corioide/patologia
Raios Infravermelhos
Neurofibromatose 1/diagnóstico
Oftalmoscopia/métodos
Tomografia de Coerência Óptica/métodos
[Mh] Termos MeSH secundário: Adulto
Doenças da Coroide/etiologia
Estudos Transversais
Diagnóstico Diferencial
Feminino
Seguimentos
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Neurofibromatose 1/complicações
Curva ROC
Reprodutibilidade dos Testes
Pele/patologia
Fatores de Tempo
Acuidade Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180101
[St] Status:MEDLINE
[do] DOI:10.1007/s00417-017-3870-z


  4 / 7581 MEDLINE  
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[PMID]:29185100
[Au] Autor:Brockmann C; Dege S; Crespo-Garcia S; Kociok N; Brockmann T; Strauß O; Joussen AM
[Ad] Endereço:Department of Ophthalmology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353, Berlin, Germany. claudia.brockmann@charite.de.
[Ti] Título:Spatial distribution of CD115 and CD11b cells and their temporal activation during oxygen-induced retinopathy in mice.
[So] Source:Graefes Arch Clin Exp Ophthalmol;256(2):313-323, 2018 Feb.
[Is] ISSN:1435-702X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The model of oxygen-induced retinopathy (OIR) is widely used to analyze pathomechanisms in retinal neovascularization. Previous studies have shown that macrophages (MP) play a key role in vessel formation in OIR, the influence of microglia (MG) having been discussed. The aim of our study was to analyze the spatial and temporal distribution and activation of MP/MG expressing CD115 and CD11b during the process of neovascularization in OIR. METHODS: We used MacGreen mice expressing the green fluorescence protein (GFP) under the promoter for CD115. CD115 cells were investigated in vivo by scanning laser ophthalmoscopy at postnatal days (P) 17 and 21 in MacGreen mice with OIR (75% oxygen from P7 to P12), and were compared to MacGreen room-air controls. In addition MP/MG were examined ex vivo using immunohistochemistry for CD11b detection on retinal flatmounts at P14, P17, and P21 of wild type mice with OIR. RESULTS: In-vivo imaging revealed the highest density of activated MP/MG in tuft areas at P17 of MacGreen mice with OIR. Tufts and regions with a high density of CD115 cells were detected close to veins, rather to arteries. In peripheral, fully vascularized areas, the distribution of CD115 cells in MacGreen mice with OIR was similar to MacGreen room-air controls. Correspondingly, immunohistochemical analyses of retinal flatmounts from wild type mice with OIR induction revealed that the number of CD11b cells significantly varies between vascular, avascular, and tuft areas as well as between the retinal layers. Activated CD11b cells were almost exclusively found in avascular areas and tufts of wild type mice with OIR induction; here, the proportion of activated cells related to the total number of CD11b cells remained stable over the course of time. CONCLUSIONS: Using two different approaches to monitor MP/MG cells, our findings demonstrated that MP/MG concentrate within pathologically vascularized areas during OIR. We were able to clarify that reactive changes of CD11b cell distribution to OIR primarily occur in the deep retinal layers. Furthermore, we found the highest proportion of activated CD11b cells in regions with pathologic neovascularization processes. Our findings support previous reports about activated MP/MG guiding revascularization in avascular areas and playing a key role in the formation and regression of neovascular tufts.
[Mh] Termos MeSH primário: Macrófagos/metabolismo
Microglia/metabolismo
Receptor de Fator Estimulador de Colônias de Macrófagos/biossíntese
Receptores de Fator Estimulador das Colônias de Granulócitos e Macrófagos/biossíntese
Neovascularização Retiniana/metabolismo
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Contagem de Células
Modelos Animais de Doenças
Angiofluoresceinografia
Fundo de Olho
Macrófagos/patologia
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
Microglia/patologia
Oftalmoscopia
Oxigênio/toxicidade
Neovascularização Retiniana/induzido quimicamente
Neovascularização Retiniana/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Granulocyte-Macrophage Colony-Stimulating Factor); EC 2.7.10.1 (Receptor, Macrophage Colony-Stimulating Factor); S88TT14065 (Oxygen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1007/s00417-017-3845-0


  5 / 7581 MEDLINE  
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[PMID]:28460051
[Au] Autor:Malmqvist L; Lindberg AW; Dahl VA; Jørgensen TM; Hamann S
[Ad] Endereço:Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Glostrup, Denmark.
[Ti] Título:Quantitatively Measured Anatomic Location and Volume of Optic Disc Drusen: An Enhanced Depth Imaging Optical Coherence Tomography Study.
[So] Source:Invest Ophthalmol Vis Sci;58(5):2491-2497, 2017 05 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: Optic disc drusen (ODD) are found in up to 2.4% of the population and are known to cause visual field defects. The purpose of the current study was to investigate how quantitatively estimated volume and anatomic location of ODD influence optic nerve function. Methods: Anatomic location, volume of ODD, and peripapillary retinal nerve fiber layer and macular ganglion cell layer thickness were assessed in 37 ODD patients using enhanced depth imaging optical coherence tomography. Volume of ODD was calculated by manual segmentation of ODD in 97 B-scans per eye. Anatomic characteristics were compared with optic nerve function using automated perimetric mean deviation (MD) and multifocal visual evoked potentials. Results: Increased age (P = 0.015); larger ODD volume (P = 0.002); and more superficial anatomic ODD location (P = 0.007) were found in patients with ODD visible by ophthalmoscopy compared to patients with buried ODD. In a multivariate analysis, a worsening of MD was significantly associated with larger ODD volume (P < 0.0001). No association was found between MD and weighted anatomic location, age, and visibility by ophthalmoscopy. Decreased ganglion cell layer thickness was significantly associated with worse MD (P = 0.025) and had a higher effect on MD when compared to retinal nerve fiber layer thickness. Conclusions: Large ODD volume is associated with optic nerve dysfunction. The worse visual field defects associated with visible ODD should only be ascribed to larger ODD volume and not to a more superficial anatomic ODD location.
[Mh] Termos MeSH primário: Drusas do Disco Óptico/diagnóstico
Disco Óptico/patologia
Tomografia de Coerência Óptica/métodos
Campos Visuais
[Mh] Termos MeSH secundário: Adulto
Potenciais Evocados Visuais
Feminino
Seres Humanos
Masculino
Fibras Nervosas/patologia
Oftalmoscopia
Drusas do Disco Óptico/fisiopatologia
Estudos Prospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180124
[Lr] Data última revisão:
180124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-21608


  6 / 7581 MEDLINE  
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[PMID]:29210009
[Au] Autor:Kawamura T; Sato I; Tamura H; Nakao YM; Kawakami K
[Ad] Endereço:Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
[Ti] Título:Influence of comorbidities on the implementation of the fundus examination in patients with newly diagnosed type 2 diabetes.
[So] Source:Jpn J Ophthalmol;62(1):68-76, 2018 Jan.
[Is] ISSN:1613-2246
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:AIMS: To investigate the influence of comorbidities on undergoing a diabetic eye examination in patients with newly diagnosed type 2 diabetes mellitus (T2DM). DESIGN: Retrospective cohort study METHODS: This was a retrospective cohort study using data from health insurance claims made between January 2005 and March 2013 in Japan. The primary outcome was implementation of the fundus examination that includes fundus photography, ophthalmoscopy and optical coherence tomography by a doctor within one year of initial drug therapy for Type2 Diabetes Mellitus (T2DM). We used multivariable logistic regression models with adjustment for demographic parameters to investigate the influence of comorbidities (hypertension and/or hyperlipidemia) on patients with T2DM receiving fundus examinations. We conducted an additional analysis to investigate whether the site of treatment might influence the performance of fundus examinations in patients with T2DM. RESULTS: A total of 6,492 patients were eligible for this analysis, of which 1,044 (16.1%) had comorbidities and 2,212 (34.1%) received the fundus examination. In the multivariable analysis, there was a significant association between comorbidities and a lower proportion of examination implementation (odds ratio [OR], 0.57; 95% confidence interval [CI], 0.48-0.68; P<0.001). The implementation proportion for patients treated for comorbidities and T2DM in the same facility was also low (OR, 0.52; 95% CI, 0.43-0.63; P<0.001). CONCLUSIONS: These results suggest that the proportion of taking fundus examination is low among patients with comorbidities, especially in patients treated at the same facility for comorbidities and T2DM. This may help to increase the proportion of T2DM patients receiving fundus examinations.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/diagnóstico
Retinopatia Diabética/diagnóstico
Fundo de Olho
Hiperlipidemias/epidemiologia
Hipertensão/epidemiologia
Exame Físico
[Mh] Termos MeSH secundário: Idoso
Estudos de Coortes
Comorbidade
Diabetes Mellitus Tipo 2/fisiopatologia
Retinopatia Diabética/fisiopatologia
Feminino
Seres Humanos
Hiperlipidemias/fisiopatologia
Hipertensão/fisiopatologia
Seguro Saúde/estatística & dados numéricos
Japão
Masculino
Meia-Idade
Oftalmoscopia
Fotografia
Estudos Retrospectivos
Tomografia de Coerência Óptica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE
[do] DOI:10.1007/s10384-017-0551-8


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[PMID]:29246204
[Au] Autor:Liu L; Wang F; Xu D; Xie C; Zou J
[Ad] Endereço:Department of Ophthalmology, Shanghai Tenth People's Hospital, Tong Ji University, Shanghai, 200072, China.
[Ti] Título:The application of wide-field laser ophthalmoscopy in fundus examination before myopic refractive surgery.
[So] Source:BMC Ophthalmol;17(1):250, 2017 Dec 15.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To evaluate wide-field laser ophthalmoscopy (Optomap 200Tx) for screening retinal lesions before myopic refractive surgery. METHODS: Seventy-eight eyes of 78 consecutive refractive surgery candidates were included in this study. All subjects underwent Optomap 200Tx, mydriatic slit-lamp lens examination and the Goldmann three-mirror contact lens examination, which was considered as the reference method for determining retinal lesions. RESULTS: Forty of 78 eyes had retinal lesions (51.28%) and three eyes had retinal breaks (3.85%), which were diagnosed by the Goldmann three-mirror contact lens examination. Compared to the Goldmann three-mirror contact lens examination, the detection rate with the Optomap 200Tx was 91.73%% for retinal lesions, while the detection rate of mydriatic slit-lamp lens exams was 81.20%. There were no statistically significant differences among the three methods used for the diagnoses of myopic conus, tessellation and retinal breaks(all p > 0.05). For peripheral retinal lesions, the detection rate of the Optomap 200Tx examinations were similar to the Goldmann three-mirror contact lens exams (all p > 0.05), but were higher than the results of slit-lamp lens examinations (all p < 0.05). Regarding the vitreoretinal adhesions, the Goldmann three-mirror contact lens examinations had higher detection rates than did the Optomap 200Tx examinations (p = 0.031). CONCLUSIONS: The Optomap 200Tx examinations is a convenient and feasible method to determine fundus pathological changes in myopic patients, especially for patients who can not endure pupil dilation. In order to avoid misdiagnosis of peripheral retinal lesions, Goldmann three-mirror contact lens examination is needed.
[Mh] Termos MeSH primário: Fundo de Olho
Miopia/complicações
Oftalmoscopia/métodos
Doenças Retinianas/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Miopia/cirurgia
Período Pré-Operatório
Procedimentos Cirúrgicos Refrativos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-017-0647-4


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[PMID]:28467200
[Au] Autor:Santesson P; Lins PE; Kalani M; Adamson U; Lelic I; von Wendt G; Fagrell B; Jörneskog G
[Ad] Endereço:1 Microcirculatory Laboratory, Division of Medicine, Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden.
[Ti] Título:Skin microvascular function in patients with type 1 diabetes: An observational study from the onset of diabetes.
[So] Source:Diab Vasc Dis Res;14(3):191-199, 2017 May.
[Is] ISSN:1752-8984
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The development of disturbances in skin microcirculation in type 1 diabetes is not well characterised. We assessed skin microcirculation longitudinally from the onset of diabetes up to 29 years of duration to investigate when such disturbances start. MATERIAL AND METHODS: Seventeen adult patients with type 1 diabetes participated. Skin microvascular function in digit IV of the left hand was investigated by laser Doppler fluxmetry (LDF, arbitrary units [AU]). LDF was carried out at rest and following one-min arterial occlusion. Time to peak LDF (s) and percentage increase of LDF (post-occlusive reactive hyperaemia, PRH%) were determined. Retinopathy was assessed from fundus photographs or ophthalmoscopic recordings. RESULTS: Skin microvascular function remained normal during the first five years. Compared with baseline and a non-diabetic reference group, time to peak LDF was prolonged after 7-9 years of diabetes ( p < 0.01). PRH% was lower than in the reference group after 7-9 years ( p < 0.01), and lower than baseline after 24-29 years of diabetes ( p < 0.05). All but one patient developed retinopathy and the first signs were found after 10 years of diabetes. CONCLUSIONS: Functional disturbances in total skin microcirculation were observed after seven years in patients with type 1 diabetes and preceded diabetic complications such as retinopathy.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 1/complicações
Angiopatias Diabéticas/etiologia
Microcirculação
Microvasos/fisiopatologia
Pele/irrigação sanguínea
[Mh] Termos MeSH secundário: Adulto
Velocidade do Fluxo Sanguíneo
Estudos de Casos e Controles
Diabetes Mellitus Tipo 1/diagnóstico
Diabetes Mellitus Tipo 1/fisiopatologia
Angiopatias Diabéticas/diagnóstico
Angiopatias Diabéticas/fisiopatologia
Neuropatias Diabéticas/diagnóstico
Neuropatias Diabéticas/etiologia
Retinopatia Diabética/diagnóstico
Retinopatia Diabética/etiologia
Progressão da Doença
Feminino
Seres Humanos
Fluxometria por Laser-Doppler
Estudos Longitudinais
Masculino
Meia-Idade
Oftalmoscopia
Estudos Prospectivos
Fluxo Sanguíneo Regional
Fatores de Risco
Temperatura Cutânea
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1177/1479164117694463


  9 / 7581 MEDLINE  
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[PMID]:29214314
[Au] Autor:Gliem M; Müller PL; Birtel J; McGuinness MB; Finger RP; Herrmann P; Hendig D; Holz FG; Charbel Issa P
[Ad] Endereço:Department of Ophthalmology, University of Bonn, Bonn, Germany.
[Ti] Título:Quantitative Fundus Autofluorescence in Pseudoxanthoma Elasticum.
[So] Source:Invest Ophthalmol Vis Sci;58(14):6159-6165, 2017 Dec 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To quantify lipofuscin-associated fundus autofluorescence in patients with pseudoxanthoma elasticum (PXE), a model disease for Bruch's membrane pathology. Methods: In this prospective, monocenter, cross-sectional case-control study, 49 patients with PXE (mean age: 46 years, range 18-62) underwent quantitative fundus autofluorescence (qAF) imaging with a modified scanning laser ophthalmoscope containing an internal fluorescent reference for normalization of images. The mean qAF values of a circular ring centered on the fovea (qAF8) were measured and compared to 108 healthy controls (mean age 40 years, range 18-64). Results: Overall, patients with PXE showed lower qAF8 values compared to controls (difference from controls -23%, 95% confidence interval [CI] -29% to -16%, P < 0.001). The reduction was most pronounced in patients older than 40 years (-30%, 95% CI -36% to -23%, P < 0.001) and was negatively correlated with the extent of Bruch's membrane calcification (r = -0.49, 95% CI: -0.67 to -0.22). The topographic distribution revealed a greater reduction of qAF values toward the optic disc than temporally compared to controls (P < 0.001). The phenotype of patients with reduced qAF values was characterized by pattern-dystrophy-like changes (71%; 10 of 14), reticular pseudodrusen (71%; 10 of 14) and limited areas of atrophy (29%, 4 of 14). Conclusions: Reduced qAF8 values are a characteristic finding in patients with PXE, indicating that Bruch's membrane disease may result in a modification of the accumulation, distribution, or composition (or a combination thereof) of lipofuscin in retinal pigment epithelial cells.
[Mh] Termos MeSH primário: Angiofluoresceinografia/métodos
Pseudoxantoma Elástico/diagnóstico
Epitélio Pigmentado da Retina/patologia
Tomografia de Coerência Óptica/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Estudos Transversais
Feminino
Fundo de Olho
Seres Humanos
Masculino
Meia-Idade
Oftalmoscopia
Estudos Prospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171215
[Lr] Data última revisão:
171215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22007


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[PMID]:28453367
[Au] Autor:Abdolrahimzadeh S; Parisi F; Mantelli F; Perdicchi A; Scuderi G
[Ad] Endereço:a Ophthalmology Unit, DAI Testa/Collo, Azienda Ospedaliera Universitaria Policlinico Umberto I, University of Rome "Sapienza" , Rome , Italy.
[Ti] Título:Retinal pigment epithelium-photoreceptor layer alterations in a patient with Sturge-Weber syndrome with diffuse choroidal hemangioma.
[So] Source:Ophthalmic Genet;38(6):567-569, 2017 Dec.
[Is] ISSN:1744-5094
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To describe an 8-year-old girl with diagnosis of Sturge-Weber syndrome (SWS) presenting with glaucoma, abnormal iris vessels, diffuse choroidal hemangioma, and small white dot-shaped "microdrusen-like" alterations of the retina in the right eye. PATIENT AND METHODS: Complete ophthalmological examination was performed with slit-lamp anterior segment assessment and fundus ophthalmoscopy. Near infrared reflectance (NIR) and enhanced depth imaging (EDI) spectral domain optical coherence tomography (SD-OCT) were carried out. RESULTS: Microdrusen-like retinal alterations observed with fundus ophthalmoscopy appeared as multiple hyperreflective dots surrounded by a hyporeflective ring on NIR. EDI SD-OCT showed increased choroidal thickness exceeding 1000 µm. B-scan cross-sectional examination on the hyperreflective dots revealed focal alterations of the retinal pigment epithelial (RPE)-photoreceptor layer. CONCLUSIONS: The increase of the choroidal thickness due to the diffuse choroidal hemangioma caused alterations of the RPE-photoreceptor layer similar to reticular pseudodrusen or pachychoroid pigment epitheliopathy.
[Mh] Termos MeSH primário: Neoplasias da Coroide/complicações
Hemangioma/complicações
Células Fotorreceptoras de Vertebrados/patologia
Doenças Retinianas/etiologia
Epitélio Pigmentado da Retina/patologia
Síndrome de Sturge-Weber/complicações
[Mh] Termos MeSH secundário: Criança
Neoplasias da Coroide/patologia
Estudos Transversais
Feminino
Hemangioma/patologia
Seres Humanos
Oftalmoscopia
Doenças Retinianas/diagnóstico
Lâmpada de Fenda
Síndrome de Sturge-Weber/diagnóstico
Tomografia de Coerência Óptica
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171201
[Lr] Data última revisão:
171201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1080/13816810.2017.1313995



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